.
nicotinic acetylcholine receptor agonist - Ontology Report - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nicotinic acetylcholine receptor agonist
go back to main search page
Accession:CHEBI:47958 term browser browse the term
Definition:An agonist that selectively binds to and activates a nicotinic acetylcholine receptor.
Synonyms:related_synonym: muscarinic agonists;   nicotinic acetylcholine receptor agonists;   nicotinic agonist;   nicotinic agonists
 alt_id: CHEBI:82738
 xref: Wikipedia:Nicotinic_acetylcholine_receptor


 Loading Annotations... 
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
X

show annotations for term's descendants           Sort by:
nicotinic acetylcholine receptor agonist term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit affects binding EXP nicotinic acetylcholine receptor agonists affect binding of Chrna7 in rat hippocampal neurons RGD PMID:15801858 RGD:1600992 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
(-)-lobeline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Lobeline results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 PMID:18448488 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit affects response to substance
multiple interactions
ISO CHRNA7 protein mutant form affects the susceptibility to Lobeline
Lobeline binds to and results in decreased activity of CHRNA7 protein; Lobeline binds to and results in increased activity of CHRNA7 protein mutant form
CTD PMID:10082212 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Lobeline results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 PMID:18448488 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Lobeline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein] CTD PMID:18448488 PMID:20106947 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein] CTD PMID:18448488 PMID:20106947 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] CTD PMID:18448488 PMID:20106947 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
JBrowse link
(E)-thiamethoxam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases activity
multiple interactions
EXP Thiamethoxam results in increased activity of ALPL protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of ALPL protein]
CTD PMID:30621503 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Anxa10 annexin A10 increases expression ISO Thiamethoxam results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:32,505,025...32,571,961
Ensembl chr16:27,738,712...27,805,648
JBrowse link
G Ar androgen receptor affects binding ISO Thiamethoxam binds to AR protein CTD PMID:31550567 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arg1 arginase 1 decreases expression ISO Thiamethoxam results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Thiamethoxam results in increased expression of ATF3 mRNA CTD PMID:33533595 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Thiamethoxam results in increased expression of BAX protein CTD PMID:33533595 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Thiamethoxam results in decreased expression of BCL2 protein CTD PMID:33533595 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl6 BCL6, transcription repressor decreases expression ISO Thiamethoxam results in decreased expression of BCL6 mRNA CTD PMID:33533595 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Btg1 BTG anti-proliferation factor 1 increases expression ISO Thiamethoxam results in increased expression of BTG1 mRNA CTD PMID:33533595 NCBI chr 7:33,228,149...33,230,406
Ensembl chr 7:31,341,027...31,343,649
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Thiamethoxam results in increased cleavage of CASP3 protein CTD PMID:33533595 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase increases expression
decreases expression
decreases activity
multiple interactions
ISO
EXP
Thiamethoxam results in increased expression of CAT mRNA
Thiamethoxam results in decreased expression of CAT mRNA
Thiamethoxam results in decreased activity of CAT protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of CAT mRNA]
CTD PMID:30621503 PMID:33533595 PMID:34181816 PMID:36958429 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Thiamethoxam results in increased expression of CCL2 mRNA CTD PMID:33533595 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Thiamethoxam results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein] CTD PMID:16981889 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO Thiamethoxam results in increased expression of CXCL5 mRNA CTD PMID:33533595 NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
multiple interactions
EXP Thiamethoxam results in decreased expression of CYP11A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP11A1 mRNA]
CTD PMID:34181816 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression
multiple interactions
EXP Thiamethoxam results in decreased expression of CYP17A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP17A1 mRNA]
CTD PMID:34181816 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression
multiple interactions
increases activity
ISO
EXP
Thiamethoxam results in increased expression of CYP19A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of CYP19A1 mRNA]
Thiamethoxam results in increased activity of CYP19A1 protein
CTD PMID:26464060 PMID:28750898 PMID:34181816 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases expression ISO Thiamethoxam results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam CTD PMID:16153789 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Thiamethoxam results in increased expression of DDIT3 mRNA; Thiamethoxam results in increased expression of DDIT3 protein CTD PMID:33533595 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Esr1 estrogen receptor 1 affects binding
decreases expression
ISO Thiamethoxam binds to ESR1 protein
Thiamethoxam results in decreased expression of ESR1 protein
CTD PMID:31550567 PMID:33533595 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Foxo3 forkhead box O3 increases expression ISO Thiamethoxam results in increased expression of FOXO3 mRNA CTD PMID:33533595 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Fshr follicle stimulating hormone receptor decreases expression ISO Thiamethoxam results in decreased expression of FSHR protein CTD PMID:33533595 NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Thiamethoxam results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression ISO Thiamethoxam results in decreased expression of GADD45B mRNA CTD PMID:33533595 NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases activity
multiple interactions
EXP Thiamethoxam results in increased activity of GOT1 protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GOT1 protein]
CTD PMID:30621503 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity EXP Thiamethoxam results in decreased activity of GPT protein CTD PMID:29197058 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
decreases expression
decreases activity
multiple interactions
ISO
EXP
Thiamethoxam results in increased expression of GPX1 mRNA
Thiamethoxam results in decreased expression of GPX1 mRNA
Thiamethoxam results in decreased activity of GPX1 protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GPX1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of GPX1 mRNA]
CTD PMID:30621503 PMID:33533595 PMID:36958429 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions
decreases expression
EXP Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of HSD3B1 mRNA] CTD PMID:34181816 NCBI chr 2:188,858,574...188,864,694
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Thiamethoxam results in increased expression of HSPA5 mRNA; Thiamethoxam results in increased expression of HSPA5 protein CTD PMID:33533595 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL1B protein]
Thiamethoxam results in increased expression of IL1B mRNA; Thiamethoxam results in increased expression of IL1B protein
CTD PMID:36958429 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL6 mRNA] CTD PMID:36958429 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression ISO Thiamethoxam results in decreased expression of ITPR1 mRNA CTD PMID:33533595 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Thiamethoxam results in decreased expression of JUNB mRNA CTD PMID:33533595 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Ldha lactate dehydrogenase A increases activity
multiple interactions
EXP Thiamethoxam results in increased activity of LDHA protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of LDHA protein]
CTD PMID:30621503 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression
multiple interactions
increases expression
ISO
EXP
Thiamethoxam results in decreased expression of LHCGR protein
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of LHCGR mRNA]
CTD PMID:33533595 PMID:34181816 NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Lst1 leukocyte specific transcript 1 increases expression ISO Thiamethoxam results in increased expression of LST1 mRNA CTD PMID:33533595 NCBI chr20:3,639,353...3,644,399
Ensembl chr20:3,634,749...3,637,997
JBrowse link
G Mc4r melanocortin 4 receptor decreases expression ISO Thiamethoxam results in decreased expression of MC4R mRNA CTD PMID:33533595 NCBI chr18:62,689,798...62,691,685
Ensembl chr18:60,419,832...60,421,719
JBrowse link
G Mmp7 matrix metallopeptidase 7 increases expression ISO Thiamethoxam results in increased expression of MMP7 mRNA CTD PMID:33533595 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Nos2 nitric oxide synthase 2 decreases activity
multiple interactions
increases expression
ISO
EXP
Thiamethoxam metabolite results in decreased activity of NOS2 protein
Silymarin inhibits the reaction [Thiamethoxam results in increased expression of NOS2 mRNA]
[Thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde
CTD PMID:29197058 PMID:36958429 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Plcg2 phospholipase C, gamma 2 decreases expression ISO Thiamethoxam results in decreased expression of PLCG2 mRNA CTD PMID:33533595 NCBI chr19:62,456,196...62,592,684
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Prnp prion protein increases expression ISO Thiamethoxam results in increased expression of PRNP mRNA CTD PMID:33533595 NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Thiamethoxam results in decreased expression of PTGS2 mRNA CTD PMID:33533595 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pthlh parathyroid hormone-like hormone decreases expression ISO Thiamethoxam results in decreased expression of PTHLH mRNA CTD PMID:33533595 NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Ptx3 pentraxin 3 increases expression ISO Thiamethoxam results in increased expression of PTX3 mRNA CTD PMID:33533595 NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:150,487,513...150,493,323
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
decreases expression
EXP Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of SCARB1 mRNA] CTD PMID:34181816 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Sesn2 sestrin 2 increases expression ISO Thiamethoxam results in increased expression of SESN2 mRNA CTD PMID:33533595 NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO Thiamethoxam results in decreased activity of SLC22A2 protein CTD PMID:31364238 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Thiamethoxam results in increased expression of SLC7A11 mRNA CTD PMID:33533595 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Sod1 superoxide dismutase 1 decreases activity
decreases expression
multiple interactions
EXP Thiamethoxam results in decreased activity of SOD1 protein
Thiamethoxam results in decreased expression of SOD1 mRNA
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of SOD1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of SOD1 mRNA]
CTD PMID:30621503 PMID:36958429 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
multiple interactions
EXP Thiamethoxam results in decreased expression of STAR mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of STAR mRNA]
CTD PMID:34181816 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Thiamethoxam results in increased expression of STC2 mRNA CTD PMID:33533595 NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Thbs4 thrombospondin 4 decreases expression ISO Thiamethoxam results in decreased expression of THBS4 mRNA CTD PMID:33533595 NCBI chr 2:25,718,219...25,760,345
Ensembl chr 2:23,983,158...24,026,313
JBrowse link
G Thra thyroid hormone receptor alpha affects binding ISO Thiamethoxam binds to THRA protein CTD PMID:31550567 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF protein]
Thiamethoxam results in increased expression of TNF mRNA; Thiamethoxam results in increased expression of TNF protein
CTD PMID:36958429 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnnt2 troponin T2, cardiac type increases secretion
multiple interactions
EXP Thiamethoxam results in increased secretion of TNNT2 protein
fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]
CTD PMID:30520268 NCBI chr13:49,819,123...49,837,125
Ensembl chr13:47,267,204...47,285,388
JBrowse link
(S)-anabasine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Anabasine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:15615518 NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects binding EXP Anabasine analog binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:15615518 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding EXP Anabasine analog binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:15615518 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Anabasine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:15615518 NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
(S)-nicotine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aacs acetoacetyl-CoA synthetase decreases expression
increases methylation
EXP Nicotine results in decreased expression of AACS mRNA
Nicotine results in increased methylation of AACS promoter
CTD PMID:26776438 NCBI chr12:36,774,471...36,817,835
Ensembl chr12:31,113,098...31,160,954
JBrowse link
G Aatk apoptosis-associated tyrosine kinase increases expression ISO Nicotine results in increased expression of AATK mRNA CTD PMID:18247414 NCBI chr10:105,789,171...105,825,634
Ensembl chr10:105,291,585...105,327,112
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
decreases expression
ISO
EXP
GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]
Nicotine results in decreased expression of ABCA1 mRNA; Nicotine results in decreased expression of ABCA1 protein
CTD PMID:30036686 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions
increases expression
decreases expression
ISO
EXP
GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]
Nicotine results in increased expression of ABCG1 protein
Nicotine results in decreased expression of ABCG1 mRNA; Nicotine results in decreased expression of ABCG1 protein
CTD PMID:30036686 PMID:31629012 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Nicotine results in increased expression of ABCG2 mRNA CTD PMID:17997037 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Abtb3 ankyrin repeat and BTB domain containing 3 increases expression ISO Nicotine results in increased expression of ABTB3 mRNA CTD PMID:21955143 PMID:23825647 NCBI chr 7:19,922,883...20,199,740
Ensembl chr 7:18,036,083...18,310,834
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ACAA2 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ACAA2 mRNA] CTD PMID:20230807 NCBI chr18:70,620,310...70,648,417
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression EXP Nicotine results in increased expression of ACACA mRNA CTD PMID:24368177 PMID:29155039 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acan aggrecan decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of ACAN mRNA; Nicotine results in decreased expression of ACAN protein
NLRP3 protein affects the reaction [Nicotine results in decreased expression of ACAN mRNA]
CTD PMID:29660438 PMID:31299270 PMID:34245815 PMID:39098741 NCBI chr 1:142,390,951...142,453,779
Ensembl chr 1:132,981,582...133,043,627
JBrowse link
G Ace angiotensin I converting enzyme increases expression ISO Nicotine results in increased expression of ACE mRNA CTD PMID:11166759 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ache acetylcholinesterase decreases activity
increases activity
multiple interactions
EXP Nicotine results in decreased activity of ACHE protein
Nicotine results in increased activity of ACHE protein
Nicotine inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein]
CTD PMID:20097188 PMID:21633116 PMID:23033686 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acot13 acyl-CoA thioesterase 13 decreases expression ISO Nicotine results in decreased expression of ACOT13 mRNA CTD PMID:17997037 NCBI chr17:40,668,404...40,680,876
Ensembl chr17:40,240,378...40,252,851
JBrowse link
G Acp1 acid phosphatase 1 decreases expression ISO Nicotine results in decreased expression of ACP1 mRNA CTD PMID:17997037 NCBI chr 6:53,233,937...53,249,576
Ensembl chr 6:47,506,380...47,522,021
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases splicing ISO Nicotine results in increased splicing of ACSL1 mRNA alternative form CTD PMID:23825647 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 multiple interactions
increases expression
ISO
EXP
Mecamylamine inhibits the reaction [Nicotine results in increased expression of ACSL6 protein]
Nicotine results in increased expression of ACSL6 mRNA
CTD PMID:22205969 NCBI chr10:38,940,668...38,999,515
Ensembl chr10:38,440,080...38,498,757
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of ACTA1 mRNA
Nicotine results in decreased expression of ACTA1 mRNA
CTD PMID:17997037 PMID:27782041 NCBI chr19:68,781,168...68,784,194
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO
EXP
Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Nicotine promotes the reaction [Quartz results in increased expression of ACTA2 protein]
Nicotine results in increased expression of ACTA2 protein
Bungarotoxins inhibits the reaction [Nicotine results in increased expression of ACTA2 protein]; Nicotine promotes the reaction [Arginine results in increased expression of ACTA2 protein]
Nicotine results in increased expression of ACTA2 mRNA; Nicotine results in increased expression of ACTA2 protein
CTD PMID:33640489 PMID:34153408 PMID:36720419 PMID:36868510 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actb actin, beta increases expression ISO Nicotine results in increased expression of ACTB mRNA CTD PMID:17997037 NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Actr1a actin related protein 1A multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ACTR1A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ACTR1A mRNA] CTD PMID:20230807 NCBI chr 1:255,179,241...255,199,009
Ensembl chr 1:245,237,826...245,256,495
JBrowse link
G Actrt2 actin-related protein T2 decreases expression EXP Nicotine results in decreased expression of ACTRT2 mRNA CTD PMID:27782041 NCBI chr 5:170,518,470...170,519,870
Ensembl chr 5:165,236,086...165,237,629
JBrowse link
G Ada adenosine deaminase multiple interactions
increases activity
EXP Sodium Acetate inhibits the reaction [Nicotine results in increased activity of ADA protein] CTD PMID:31857090 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Adam19 ADAM metallopeptidase domain 19 increases expression ISO Nicotine results in increased expression of ADAM19 mRNA CTD PMID:23825647 NCBI chr10:30,992,713...31,084,455
Ensembl chr10:30,491,405...30,583,105
JBrowse link
G Adcy7 adenylate cyclase 7 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ADCY7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA] CTD PMID:20230807 NCBI chr19:34,913,154...34,972,366
Ensembl chr19:18,740,875...18,776,311
JBrowse link
G Adgra1 adhesion G protein-coupled receptor A1 decreases expression ISO Nicotine results in decreased expression of ADGRA1 mRNA CTD PMID:21955143 NCBI chr 1:204,059,218...204,102,869
Ensembl chr 1:194,629,726...194,672,550
JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 increases expression ISO Nicotine results in increased expression of ADGRG1 mRNA CTD PMID:23825647 NCBI chr19:10,009,983...10,047,138
Ensembl chr19:10,003,975...10,041,108
JBrowse link
G Adgrl1 adhesion G protein-coupled receptor L1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADGRL1 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ADGRL1 mRNA] CTD PMID:20230807 NCBI chr19:41,107,162...41,148,752
Ensembl chr19:24,204,360...24,244,139
JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP Nicotine results in increased expression of ADIPOR2 mRNA CTD PMID:22265867 NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:152,524,623...152,559,355
JBrowse link
G Adk adenosine kinase increases expression ISO Nicotine results in increased expression of ADK mRNA CTD PMID:17997037 NCBI chr15:2,912,543...3,295,745
Ensembl chr15:2,863,244...3,246,510
JBrowse link
G Adm2 adrenomedullin 2 multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in decreased expression of ADM2 protein CTD PMID:19910445 NCBI chr 7:122,272,808...122,274,594
Ensembl chr 7:120,393,179...120,396,331
JBrowse link
G Adnp activity-dependent neuroprotector homeobox multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADNP mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADNP mRNA] CTD PMID:20230807 NCBI chr 3:177,310,258...177,340,379
Ensembl chr 3:156,891,381...156,917,312
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Nicotine results in decreased expression of ADORA2A mRNA CTD PMID:21955143 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions
increases expression
ISO [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine
Nicotine results in increased expression of ADRB1 mRNA
CTD PMID:17003101 PMID:17369603 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases expression
ISO [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] which results in decreased susceptibility to Nicotine
Nicotine results in increased expression of ADRB2 mRNA
CTD PMID:17003101 PMID:17369603 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Adtrp androgen-dependent TFPI-regulating protein increases expression ISO Nicotine results in increased expression of ADTRP mRNA CTD PMID:23825647 NCBI chr17:23,113,578...23,199,616
Ensembl chr17:22,930,740...22,993,826
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression EXP Nicotine results in increased expression of AGTR1A protein CTD PMID:22691361 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr1b angiotensin II receptor, type 1b increases expression EXP Nicotine results in increased expression of AGTR1B mRNA CTD PMID:22728133 NCBI chr 2:104,774,005...104,849,262
Ensembl chr 2:102,844,969...102,920,232
JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression
affects expression
EXP Nicotine results in decreased expression of AGTR2 mRNA; Nicotine results in decreased expression of AGTR2 protein
Nicotine affects the expression of AGTR2 protein
CTD PMID:19429393 PMID:22691361 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Nicotine results in increased expression of AHR mRNA CTD PMID:34171359 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor decreases expression EXP Nicotine results in decreased expression of AHRR protein CTD PMID:35577041 NCBI chr 1:30,822,219...30,917,251
Ensembl chr 1:28,993,634...29,088,673
JBrowse link
G Ak3 adenylate kinase 3 increases expression ISO Nicotine results in increased expression of AK3 mRNA CTD PMID:17456735 NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:226,739,318...226,764,625
JBrowse link
G Ak5 adenylate kinase 5 increases expression ISO Nicotine results in increased expression of AK5 mRNA CTD PMID:21955143 NCBI chr 2:244,057,240...244,241,372
Ensembl chr 2:241,397,297...241,581,458
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of AKR1A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AKR1A1 mRNA] CTD PMID:20230807 NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
increases expression
increases phosphorylation
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein; CDK1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CDK2 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CSNK2A1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; CYP1A1 protein affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; Nicotine affects the reaction [Camptothecin affects the phosphorylation of AKT1 protein]; Nicotine affects the reaction [Fluorouracil affects the phosphorylation of AKT1 protein]; Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein
Nicotine results in decreased phosphorylation of AKT1 protein
Nicotine results in increased expression of AKT1 mRNA
CTD PMID:12511591 PMID:15983034 PMID:20727180 PMID:24095863 PMID:30836163 More... NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 affects expression
increases expression
EXP
ISO
Nicotine affects the expression of AKT2 mRNA
Nicotine results in increased expression of AKT2 mRNA
CTD PMID:31945395 PMID:31972234 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Alad aminolevulinate dehydratase decreases activity ISO Nicotine results in decreased activity of ALAD protein CTD PMID:8687997 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Alb albumin increases expression
multiple interactions
decreases expression
EXP
ISO
Nicotine results in increased expression of ALB protein
dexpanthenol inhibits the reaction [Nicotine results in decreased expression of ALB protein]
CTD PMID:25662863 PMID:36720419 PMID:38229321 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases activity
multiple interactions
ISO Nicotine results in increased activity of ALDH1A1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA]
CTD PMID:20230807 PMID:23219715 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type increases expression ISO Nicotine results in increased expression of ALOX12 mRNA CTD PMID:16254210 NCBI chr10:55,456,923...55,469,239
Ensembl chr10:54,958,271...54,970,542
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
increases expression
ISO [RTKI cpd co-treated with AG 1879] inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; AG 1879 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; RTKI cpd inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of ALOX5 mRNA]
Nicotine results in increased expression of ALOX5 mRNA; Nicotine results in increased expression of ALOX5 protein
CTD PMID:14569062 PMID:20061081 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 increases expression ISO Nicotine results in increased expression of AMD1 mRNA CTD PMID:16949557 NCBI chr20:45,250,289...45,324,939
Ensembl chr20:43,697,237...43,711,476
JBrowse link
G Amhr2 anti-Mullerian hormone receptor type 2 decreases expression ISO Nicotine results in decreased expression of AMHR2 mRNA CTD PMID:18247414 NCBI chr 7:135,454,517...135,470,183
Ensembl chr 7:133,579,393...133,588,258
JBrowse link
G Angpt4 angiopoietin 4 increases expression ISO Nicotine results in increased expression of ANGPT4 mRNA CTD PMID:23825647 NCBI chr 3:160,880,539...160,913,923
Ensembl chr 3:140,420,389...140,453,583
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression EXP Nicotine results in decreased expression of ANGPTL4 mRNA CTD PMID:32512034 NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Ano3 anoctamin 3 decreases expression ISO Nicotine results in decreased expression of ANO3 mRNA CTD PMID:21955143 NCBI chr 3:117,690,242...118,004,695
Ensembl chr 3:97,238,354...97,550,154
JBrowse link
G Anxa1 annexin A1 decreases expression EXP Nicotine results in decreased expression of ANXA1 mRNA CTD PMID:26776438 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Apeh acylaminoacyl-peptide hydrolase decreases expression ISO Nicotine results in decreased expression of APEH mRNA CTD PMID:16949557 NCBI chr 8:117,652,390...117,661,502
Ensembl chr 8:108,773,794...108,782,933
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA] CTD PMID:20230807 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Api5 apoptosis inhibitor 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of API5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of API5 mRNA] CTD PMID:20230807 NCBI chr 3:100,833,417...100,858,580
Ensembl chr 3:80,378,096...80,403,264
JBrowse link
G Apoe apolipoprotein E increases expression ISO Nicotine results in increased expression of APOE mRNA CTD PMID:17997037 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases metabolic processing
decreases expression
ISO
EXP
[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form; Bungarotoxins inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]]; Mecamylamine inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]]; Nicotine inhibits the reaction [Copper promotes the reaction [APP protein binds to APP protein]]; Nicotine inhibits the reaction [Copper results in increased expression of APP mRNA]; Nicotine inhibits the reaction [Copper results in increased expression of APP protein]; Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form]; Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein]
APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]; spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one inhibits the reaction [APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]]
Nicotine results in decreased expression of APP protein alternative form
Nicotine results in decreased expression of APP mRNA; Nicotine results in decreased expression of APP protein
CTD PMID:16474004 PMID:16627626 PMID:17135361 PMID:29618714 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp4 aquaporin 4 increases expression ISO Nicotine results in increased expression of AQP4 mRNA CTD PMID:21955143 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression ISO Nicotine results in increased expression of ARC mRNA CTD PMID:23825647 NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Arf1 ARF GTPase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ARF1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA] CTD PMID:20230807 NCBI chr10:44,497,543...44,513,994
Ensembl chr10:43,997,986...44,014,434
JBrowse link
G Arf3 ARF GTPase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ARF3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF3 mRNA] CTD PMID:20230807 NCBI chr 7:131,765,039...131,792,075
Ensembl chr 7:129,886,082...129,912,002
JBrowse link
G Arglu1 arginine and glutamate rich 1 increases expression ISO Nicotine results in increased expression of ARGLU1 mRNA CTD PMID:16949557 NCBI chr16:87,455,097...87,479,148
Ensembl chr16:80,753,315...80,777,349
JBrowse link
G Arhgef26 Rho guanine nucleotide exchange factor 26 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARHGEF26 mRNA CTD PMID:28065790 NCBI chr 2:148,889,405...149,000,538
Ensembl chr 2:146,739,631...146,850,819
JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 decreases expression ISO Nicotine results in decreased expression of ARHGEF7 mRNA CTD PMID:12588870 NCBI chr16:84,373,123...84,484,759
Ensembl chr16:77,671,023...77,782,697
JBrowse link
G Arid1a AT-rich interaction domain 1A decreases expression ISO Nicotine results in decreased expression of ARID1A mRNA CTD PMID:17997037 NCBI chr 5:151,192,014...151,269,291
Ensembl chr 5:145,908,181...145,985,564
JBrowse link
G Arl15 ARF like GTPase 15 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARL15 mRNA CTD PMID:28065790 NCBI chr 2:47,171,377...47,555,666
Ensembl chr 2:45,438,242...45,822,559
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator decreases expression EXP Nicotine results in decreased expression of ARNT protein CTD PMID:35577041 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 decreases expression ISO Nicotine results in decreased expression of ARPP21 mRNA CTD PMID:21955143 NCBI chr 8:120,912,964...121,077,586
Ensembl chr 8:112,034,642...112,194,297
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine results in increased phosphorylation of and results in increased activity of SRC protein] CTD PMID:16862215 NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Arvcf ARVCF, delta catenin family member decreases response to substance ISO ARVCF gene mutant form results in decreased susceptibility to Nicotine CTD PMID:38025780 NCBI chr11:96,092,451...96,150,144
Ensembl chr11:82,587,881...82,645,805
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression EXP Nicotine results in decreased expression of ASCL1 mRNA CTD PMID:28555334 NCBI chr 7:23,790,642...23,793,509
Ensembl chr 7:21,903,126...21,905,993
JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 decreases expression EXP Nicotine results in decreased expression of ASCL2 mRNA CTD PMID:24368670 NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:198,148,999...198,151,406
JBrowse link
G Aspm assembly factor for spindle microtubules multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ASPM mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ASPM mRNA] CTD PMID:20230807 NCBI chr13:53,625,584...53,674,489
Ensembl chr13:51,074,849...51,123,755
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Nicotine results in increased expression of ATF3 mRNA CTD PMID:17456735 PMID:24927667 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Nicotine inhibits the reaction [Tunicamycin results in increased expression of ATF6 protein] CTD PMID:18477628 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form] CTD PMID:23907605 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atoh1 atonal bHLH transcription factor 1 multiple interactions
increases expression
ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of ATOH1 mRNA] CTD PMID:23056257 NCBI chr 4:95,241,933...95,244,028
Ensembl chr 4:93,912,068...93,914,154
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression EXP Nicotine results in decreased expression of ATP5F1A protein CTD PMID:28681937 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon increases splicing ISO Nicotine results in increased splicing of ATP5F1E mRNA alternative form CTD PMID:23825647 NCBI chr 3:183,677,270...183,680,172
Ensembl chr 3:163,260,476...163,261,450
JBrowse link
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ATP6V0A4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V0A4 mRNA] CTD PMID:20230807 NCBI chr 4:67,727,145...67,809,092
Ensembl chr 4:66,760,159...66,842,110
JBrowse link
G Atp9a ATPase phospholipid transporting 9A (putative) multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ATP9A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP9A mRNA] CTD PMID:20230807 NCBI chr 3:177,779,203...177,886,431
Ensembl chr 3:157,360,359...157,467,818
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form] CTD PMID:23907605 NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Atrn attractin multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATRN mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ATRN mRNA] CTD PMID:20230807 NCBI chr 3:138,563,271...138,697,360
Ensembl chr 3:118,110,229...118,244,322
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression
decreases expression
ISO Nicotine results in increased expression of ATRX mRNA
Nicotine results in decreased expression of ATRX mRNA
CTD PMID:16949557 PMID:21955143 NCBI chr  X:74,916,548...75,062,880
Ensembl chr  X:70,850,981...70,997,330
JBrowse link
G Avp arginine vasopressin decreases expression
increases secretion
ISO
EXP
Nicotine results in decreased expression of AVP mRNA
Nicotine results in increased secretion of AVP protein alternative form
CTD PMID:3681699 PMID:17456735 PMID:28555334 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G B4galt2 beta-1,4-galactosyltransferase 2 decreases expression ISO Nicotine results in decreased expression of B4GALT2 mRNA CTD PMID:17997037 NCBI chr 5:136,697,981...136,707,783
Ensembl chr 5:131,412,541...131,421,013
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
decreases phosphorylation
ISO
EXP
Nicotine results in decreased expression of BAD mRNA
Nicotine results in decreased phosphorylation of BAD protein
CTD PMID:18247414 PMID:20447445 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bap1 BRCA1 associated deubiquitinase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BAP1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAP1 mRNA] CTD PMID:20230807 NCBI chr16:6,453,126...6,461,952
Ensembl chr16:6,446,709...6,455,535
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases phosphorylation
decreases expression
increases expression
multiple interactions
affects localization
ISO
EXP
Nicotine results in increased phosphorylation of BAX protein
Nicotine results in decreased expression of BAX protein
Nicotine results in increased expression of BAX protein
dexpanthenol inhibits the reaction [Nicotine results in increased expression of BAX protein]; Folic Acid inhibits the reaction [Nicotine results in increased expression of BAX protein]
Nicotine results in increased expression of BAX mRNA; Nicotine results in increased expression of BAX protein
Nicotine affects the localization of BAX protein
Nicotine results in decreased expression of BAX mRNA; Nicotine results in decreased expression of BAX protein
3-methyladenine inhibits the reaction [Nicotine results in increased expression of BAX protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of BAX protein; MK-886 inhibits the reaction [Nicotine results in decreased expression of BAX protein]; Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] affects the localization of BAX protein]; PRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein]
CTD PMID:15831280 PMID:17135361 PMID:17525161 PMID:18203686 PMID:18676776 More... NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcas1 brain enriched myelin associated protein 1 increases expression ISO Nicotine results in increased expression of BCAS1 mRNA CTD PMID:21955143 NCBI chr 3:179,554,754...179,637,800
Ensembl chr 3:159,136,083...159,219,106
JBrowse link
G Bcl11b BCL11 transcription factor B increases expression ISO Nicotine results in increased expression of BCL11B mRNA CTD PMID:21955143 NCBI chr 6:132,598,968...132,692,123
Ensembl chr 6:126,834,531...126,928,224
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression
increases phosphorylation
ISO
EXP
3-methyladenine inhibits the reaction [Nicotine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; edelfosine inhibits the reaction [Nicotine results in increased phosphorylation of BCL2 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of BCL2 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein]
royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA]
Folic Acid inhibits the reaction [Nicotine results in decreased expression of BCL2 protein]
Nicotine results in decreased expression of BCL2 mRNA; Nicotine results in decreased expression of BCL2 protein
Nicotine results in increased expression of BCL2 mRNA; Nicotine results in increased expression of BCL2 protein; Nicotine results in increased expression of BCL2 protein modified form
CTD PMID:12421819 PMID:15831280 PMID:18448488 PMID:18676776 PMID:20061081 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Nicotine results in decreased expression of BCL2A1 mRNA CTD PMID:18247414 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of BCL2L1 mRNA
Nicotine results in decreased expression of BCL2L1 protein
resveratrol inhibits the reaction [Nicotine results in decreased expression of BCL2L1 mRNA]
CTD PMID:22687363 PMID:38229321 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479
JBrowse link
G Bcl2l10 Bcl2-like 10 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2L10 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2L10 mRNA] CTD PMID:20230807 NCBI chr 8:84,987,833...84,993,878
Ensembl chr 8:76,107,326...76,113,367
JBrowse link
G Bdnf brain-derived neurotrophic factor affects response to substance
multiple interactions
increases expression
affects expression
increases secretion
ISO
EXP
BDNF gene polymorphism affects the susceptibility to Nicotine
[Nicotine co-treated with Quartz] results in increased expression of BDNF protein
Nicotine results in increased expression of BDNF mRNA
Nicotine affects the expression of BDNF mRNA
Nicotine results in increased secretion of BDNF protein
methyllycaconitine inhibits the reaction [Nicotine results in increased secretion of BDNF protein]
CTD PMID:9503263 PMID:9832142 PMID:16790237 PMID:17186223 PMID:20426880 More... NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of BECN1 mRNA
Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]
dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]]; Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]
CTD PMID:30605750 PMID:31926917 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
decreases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of BGLAP
Nicotine results in decreased expression of BGLAP mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP]
CTD PMID:19436947 PMID:29981921 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of BIRC2 protein
Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein]
CTD PMID:20727180 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression
ISO Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Hexamethonium affects the reaction [Nicotine results in increased expression of BIRC5 protein]; Nicotine inhibits the reaction [RB1 protein binds to BIRC5 promoter]; Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter]
Nicotine results in increased expression of BIRC5 mRNA; Nicotine results in increased expression of BIRC5 protein
CTD PMID:16601104 PMID:19896492 PMID:20727180 PMID:21267677 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger increases expression
multiple interactions
ISO Nicotine results in increased expression of BMI1 mRNA; Nicotine results in increased expression of BMI1 protein
SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA]
CTD PMID:23219715 NCBI chr17:86,240,683...86,250,044
Ensembl chr17:81,332,214...81,388,690
JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression EXP Nicotine results in decreased expression of BMP4 mRNA CTD PMID:20339300 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions ISO [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PRDM16 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA CTD PMID:33091441 NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA] CTD PMID:20230807 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Nicotine results in decreased expression of BOK mRNA CTD PMID:21955143 NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression ISO Nicotine results in decreased expression of BRAF mRNA; Nicotine results in decreased expression of BRAF protein CTD PMID:17135361 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
multiple interactions
ISO Nicotine results in decreased expression of BRCA1 mRNA
Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form]
CTD PMID:18247414 PMID:23907605 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brd2 bromodomain containing 2 increases expression ISO Nicotine results in increased expression of BRD2 mRNA CTD PMID:33640489 NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,151...4,735,388
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of BST2 mRNA CTD PMID:37951547 NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,217,407...18,220,979
JBrowse link
G Btf3 basic transcription factor 3 decreases expression ISO Nicotine results in decreased expression of BTF3 mRNA CTD PMID:18247414 NCBI chr 2:31,394,010...31,401,138
Ensembl chr 2:29,659,231...29,666,879
Ensembl chr13:29,659,231...29,666,879
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Nicotine results in increased expression of BTG2 mRNA CTD PMID:17456735 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Btk Bruton tyrosine kinase decreases expression ISO Nicotine results in decreased expression of BTK mRNA CTD PMID:18247414 NCBI chr  X:102,016,070...102,055,448
Ensembl chr  X:97,722,802...97,761,853
JBrowse link
G C1r complement C1r multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of C1R mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1R mRNA] CTD PMID:20230807 NCBI chr 4:159,099,013...159,109,770
Ensembl chr 4:157,412,692...157,423,484
JBrowse link
G C1s complement C1s multiple interactions ISO Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1S mRNA] CTD PMID:20230807 NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:157,430,117...157,442,303
JBrowse link
G C3ar1 complement C3a receptor 1 increases expression ISO Nicotine results in increased expression of C3AR1 mRNA CTD PMID:23825647 NCBI chr 4:157,747,419...157,756,609
Ensembl chr 4:156,075,389...156,084,701
JBrowse link
G C5ar1 complement C5a receptor 1 decreases expression ISO Nicotine results in decreased expression of C5AR1 mRNA CTD PMID:18247414 NCBI chr 1:86,077,309...86,088,001 JBrowse link
G C7 complement C7 multiple interactions
increases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of C7 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA] CTD PMID:16949557 NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:54,088,116...54,158,535
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C increases expression ISO Nicotine results in increased expression of CACNA1C protein CTD PMID:11756415 NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D increases expression ISO Nicotine results in increased expression of CACNA1D protein CTD PMID:11756415 NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,228,306...5,668,215
JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F increases expression ISO Nicotine results in increased expression of CACNA1F mRNA CTD PMID:11756415 NCBI chr  X:17,539,992...17,568,308
Ensembl chr  X:14,868,024...14,896,413
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases expression EXP Nicotine results in increased expression of CACNA1H mRNA CTD PMID:27782041 NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression ISO Nicotine results in increased expression of CACNA2D1 protein CTD PMID:11756415 NCBI chr 4:19,902,324...20,330,287
Ensembl chr 4:18,951,002...19,374,969
JBrowse link
G Cacng1 calcium voltage-gated channel auxiliary subunit gamma 1 decreases expression EXP Nicotine results in decreased expression of CACNG1 mRNA CTD PMID:27782041 NCBI chr10:93,152,558...93,165,246
Ensembl chr10:92,652,614...92,665,783
JBrowse link
G Cadm3 cell adhesion molecule 3 increases expression EXP Nicotine results in increased expression of CADM3 mRNA CTD PMID:27782041 NCBI chr13:88,317,124...88,349,718
Ensembl chr13:85,786,483...85,817,749
JBrowse link
G Calb1 calbindin 1 increases expression
multiple interactions
EXP Nicotine results in increased expression of CALB1 protein
Mecamylamine inhibits the reaction [Nicotine results in increased expression of CALB1 protein]
CTD PMID:11226671 NCBI chr 5:34,172,612...34,199,555
Ensembl chr 5:29,375,642...29,402,431
JBrowse link
G Calcrl calcitonin receptor like receptor multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in increased expression of CALCRL protein CTD PMID:19910445 NCBI chr 3:89,835,071...89,932,616
Ensembl chr 3:69,430,120...69,525,910
JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CALM1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CALM1 mRNA] CTD PMID:20230807 NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:119,487,621...119,498,227
JBrowse link
G Calr calreticulin increases expression ISO Nicotine results in increased expression of CALR mRNA CTD PMID:16949557 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases expression ISO Nicotine results in increased expression of CAMK2A mRNA CTD PMID:21955143 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression ISO Nicotine results in decreased expression of CAMK4 mRNA CTD PMID:17997037 NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,585,269...24,802,487
JBrowse link
G Camp cathelicidin antimicrobial peptide increases expression ISO Nicotine results in increased expression of CAMP mRNA CTD PMID:23825647 NCBI chr 8:118,720,184...118,721,998
Ensembl chr 8:109,841,729...109,843,543
JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 decreases expression ISO Nicotine results in decreased expression of CAP1 mRNA CTD PMID:21955143 NCBI chr 5:140,427,265...140,507,678
Ensembl chr 5:135,142,112...135,168,769
JBrowse link
G Capn10 calpain 10 increases expression ISO Nicotine results in increased expression of CAPN10 mRNA CTD PMID:17997037 NCBI chr 9:100,943,665...100,957,910
Ensembl chr 9:93,498,478...93,510,494
JBrowse link
G Capza2 capping actin protein of muscle Z-line subunit alpha 2 increases expression ISO Nicotine results in increased expression of CAPZA2 mRNA CTD PMID:16949557 NCBI chr 4:46,944,040...46,979,930
Ensembl chr 4:45,977,807...46,013,864
JBrowse link
G Car3 carbonic anhydrase 3 decreases expression EXP Nicotine results in decreased expression of CAR3 mRNA CTD PMID:27782041 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Cartpt CART prepropeptide decreases expression EXP
ISO
Nicotine results in decreased expression of CARTPT protein
Nicotine results in decreased expression of CARTPT mRNA
CTD PMID:18247414 PMID:23623838 NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:31,255,098...31,290,713
JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression
ISO
EXP
CHRNA5 protein affects the reaction [Nicotine results in increased expression of and results in increased cleavage of CASP1 protein]; Nicotine affects the reaction [Staurosporine affects the localization of CASP1 protein]; Nicotine inhibits the reaction [Staurosporine results in increased activity of CASP1 protein]; Nicotine results in increased expression of and results in increased cleavage of CASP1 protein
Nicotine results in increased expression of CASP1 mRNA
Nicotine results in increased expression of CASP1 protein
CTD PMID:16927020 PMID:35131329 PMID:39098741 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 multiple interactions ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP12 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP12 mRNA]
Nicotine inhibits the reaction [Tunicamycin results in increased activity of CASP12 protein]
CTD PMID:18477628 PMID:20230807 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp14 caspase 14 increases expression ISO Nicotine results in increased expression of CASP14 mRNA CTD PMID:23825647 NCBI chr 7:11,577,315...11,583,987
Ensembl chr 7:10,926,725...10,933,405
JBrowse link
G Casp2 caspase 2 affects expression EXP Nicotine affects the expression of CASP2 mRNA CTD PMID:20426880 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
affects expression
decreases expression
decreases activity
ISO
EXP
geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein]; MK-886 inhibits the reaction [Nicotine results in decreased expression of CASP3 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CASP3 protein modified form]; Nicotine inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]
Nicotine results in increased cleavage of CASP3 protein
Nicotine results in increased activity of CASP3 protein; Nicotine results in increased activity of CASP3 protein alternative form
Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein
Nicotine affects the expression of CASP3 mRNA
[Ethanol co-treated with Nicotine] results in increased expression of CASP3 protein; Nicotine inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein modified form
Nicotine results in increased expression of CASP3; Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein; Nicotine results in increased expression of CASP3 protein modified form
Nicotine results in decreased expression of CASP3 mRNA; Nicotine results in decreased expression of CASP3 protein
[Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP3 protein]; Resveratrol inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]; royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]
Nicotine results in decreased activity of CASP3 protein
CTD PMID:11701223 PMID:12115584 PMID:12218695 PMID:15831280 PMID:16237857 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 affects expression EXP Nicotine affects the expression of CASP8 mRNA CTD PMID:20426880 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
decreases expression
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CASP9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP9 mRNA]
Nicotine results in increased expression of CASP9 protein
dexpanthenol inhibits the reaction [Nicotine results in increased expression of CASP9 protein]; Folic Acid inhibits the reaction [Nicotine results in increased expression of CASP9 protein]
Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein]
Nicotine results in decreased expression of CASP9 mRNA
CTD PMID:16949557 PMID:18676776 PMID:20230807 PMID:29972271 PMID:38229321 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase multiple interactions
decreases activity
increases activity
EXP
ISO
[acephate co-treated with methamidophos co-treated with Nicotine] results in increased activity of CAT protein; [Ethanol co-treated with Nicotine] results in decreased activity of CAT protein; [Ethanol co-treated with Nicotine] results in increased activity of CAT protein; Folic Acid inhibits the reaction [Nicotine results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]
Nicotine results in increased activity of CAT protein
CTD PMID:10509436 PMID:10874619 PMID:10906423 PMID:11747978 PMID:15925865 More... NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav2 caveolin 2 decreases expression ISO Nicotine results in decreased expression of CAV2 mRNA CTD PMID:33640489 NCBI chr 4:46,582,681...46,590,058
Ensembl chr 4:45,616,712...45,624,244
JBrowse link
G Cbl Cbl proto-oncogene increases expression ISO Nicotine results in increased expression of CBL mRNA CTD PMID:18247414 NCBI chr 8:53,384,656...53,468,067
Ensembl chr 8:44,489,410...44,571,176
JBrowse link
G Cbln1 cerebellin 1 precursor increases expression ISO Nicotine results in increased expression of CBLN1 mRNA CTD PMID:21955143 NCBI chr19:35,782,151...35,785,960
Ensembl chr19:19,608,716...19,612,572
JBrowse link
G Cbx3 chromobox 3 increases expression ISO Nicotine results in increased expression of CBX3 mRNA CTD PMID:16949557 NCBI chr 4:81,876,155...81,889,912
Ensembl chr 4:80,546,010...80,559,283
Ensembl chr 4:80,546,010...80,559,283
JBrowse link
G Cbx5 chromobox 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CBX5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA] CTD PMID:20230807 NCBI chr 7:136,203,827...136,254,575
Ensembl chr 7:134,331,335...134,375,022
JBrowse link
G Ccdc136 coiled-coil domain containing 136 increases expression ISO Nicotine results in increased expression of CCDC136 mRNA CTD PMID:21955143 NCBI chr 4:58,963,196...58,992,962
Ensembl chr 4:57,997,853...58,027,646
JBrowse link
G Ccdc159 coiled-coil domain containing 159 increases expression ISO Nicotine results in increased expression of CCDC159 mRNA CTD PMID:23825647 NCBI chr 8:28,733,988...28,742,646
Ensembl chr 8:20,457,909...20,466,562
JBrowse link
G Ccdc167 coiled-coil domain containing 167 increases expression ISO Nicotine results in increased expression of CCDC167 mRNA CTD PMID:23825647 NCBI chr20:7,768,425...7,783,181
Ensembl chr20:7,751,782...7,781,613
JBrowse link
G Ccdc88a coiled coil domain containing 88A increases expression ISO Nicotine results in increased expression of CCDC88A mRNA CTD PMID:17456735 NCBI chr14:107,304,654...107,456,104
Ensembl chr14:103,103,513...103,252,368
JBrowse link
G Cck cholecystokinin decreases expression ISO Nicotine results in decreased expression of CCK mRNA CTD PMID:21955143 NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
decreases secretion
ISO
EXP
Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA]
Nicotine results in decreased expression of CCL2 mRNA; Nicotine results in decreased expression of CCL2 protein
Nicotine results in decreased secretion of CCL2 protein
Mecamylamine inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA]
CTD PMID:15135227 PMID:15976189 PMID:22093924 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO Nicotine results in increased expression of CCL5 mRNA CTD PMID:18247414 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Nicotine results in increased expression of CCN1 mRNA CTD PMID:17456735 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression EXP Nicotine results in increased expression of CCN2 protein CTD PMID:22691361 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO Nicotine results in increased expression of CCN5 mRNA CTD PMID:23825647 NCBI chr 3:172,910,670...172,922,064
Ensembl chr 3:152,491,220...152,502,636
JBrowse link
G Ccna2 cyclin A2 increases expression ISO Nicotine results in increased expression of CCNA2 protein CTD PMID:18448488 PMID:20106947 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 increases expression
multiple interactions
ISO Nicotine results in increased expression of CCNB1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNB1 mRNA]
CTD PMID:20106947 PMID:20230807 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
decreases expression
increases activity
ISO
EXP
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of CCND1 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein]; Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of CCND1 protein]
Nicotine results in decreased expression of CCND1 mRNA; Nicotine results in decreased expression of CCND1 protein
Nicotine results in increased activity of CCND1 promoter
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CCND1 mRNA]
Nicotine results in increased expression of CCND1 mRNA; Nicotine results in increased expression of CCND1 protein
CTD PMID:15574422 PMID:15983034 PMID:17135361 PMID:18448488 PMID:18805435 More... NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCND2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCND2 mRNA]
Nicotine results in decreased expression of CCND2 protein
CTD PMID:15231866 PMID:20230807 NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccne1 cyclin E1 multiple interactions
increases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of CCNE1 protein] CTD PMID:20061081 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Nicotine results in increased expression of CCNG2 mRNA CTD PMID:23416264 NCBI chr14:15,088,694...15,097,190
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Ccnl2 cyclin L2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNL2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNL2 mRNA] CTD PMID:20230807 NCBI chr 5:171,698,951...171,711,037
Ensembl chr 5:166,417,508...166,436,882
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO Nicotine results in increased expression of CCR5 mRNA CTD PMID:18247414 NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO Nicotine results in decreased expression of CCR6 mRNA CTD PMID:18247414 NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:52,474,168...52,498,603
JBrowse link
G Ccs copper chaperone for superoxide dismutase increases expression ISO Nicotine results in increased expression of CCS protein CTD PMID:16627626 NCBI chr 1:211,543,192...211,564,354
Ensembl chr 1:202,113,804...202,134,915
JBrowse link
G Cd151 CD151 molecule (Raph blood group) multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CD151 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CD151 mRNA] CTD PMID:20230807 NCBI chr 1:205,994,300...205,998,307
Ensembl chr 1:196,565,181...196,568,753
JBrowse link
G Cd4 Cd4 molecule decreases expression ISO Nicotine results in decreased expression of CD4 mRNA CTD PMID:18247414 NCBI chr 4:159,355,147...159,381,636
Ensembl chr 4:157,668,878...157,695,191
JBrowse link
G Cd44 CD44 molecule multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CD44 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD44 mRNA] CTD PMID:20230807 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cd46 CD46 molecule increases expression ISO Nicotine results in increased expression of CD46 mRNA CTD PMID:16949557 NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Cd59b CD59b molecule increases expression ISO Nicotine results in increased expression of CD59 mRNA CTD PMID:18247414 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CD68 mRNA CTD PMID:29617909 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Cd86 CD86 molecule increases expression EXP Nicotine results in increased expression of CD86 mRNA CTD PMID:27782041 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cd9 CD9 molecule multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CD9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD9 mRNA] CTD PMID:20230807 NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:158,256,328...158,289,222
JBrowse link
G Cdc25a cell division cycle 25A multiple interactions ISO Nicotine inhibits the reaction [E2F4 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC25A promoter] CTD PMID:16862215 NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdc42 cell division cycle 42 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDC42 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CDC42 mRNA] CTD PMID:20230807 NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Cdc6 cell division cycle 6 multiple interactions ISO Nicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr10:84,360,361...84,374,239
Ensembl chr10:83,864,638...83,878,011
JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression
ISO MK-886 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]; U 0126 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]
[Nicotine co-treated with Quartz] results in increased expression of CDH1 protein
Nicotine results in decreased expression of CDH1 mRNA; Nicotine results in decreased expression of CDH1 protein
CTD PMID:18844224 PMID:20061081 PMID:23219715 PMID:36868510 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh11 cadherin 11 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDH11 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA] CTD PMID:20230807 NCBI chr19:2,152,961...2,312,140
Ensembl chr19:2,148,458...2,304,272
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO [Nicotine co-treated with Quartz] results in increased expression of CDH2 protein; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of CDH2 protein] CTD PMID:36868510 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of CDK1 protein
CDK1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 affects the reaction [Nicotine results in increased expression of CDK1 protein]
CTD PMID:35929799 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk13 cyclin-dependent kinase 13 increases expression ISO Nicotine results in increased expression of CDK13 mRNA CTD PMID:16949557 NCBI chr17:51,945,975...52,040,218
Ensembl chr17:47,251,163...47,341,721
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO CDK2 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein] CTD PMID:35929799 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO Bungarotoxins inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein]; Nicotine promotes the reaction [NFATC2 protein results in decreased expression of CDK4 protein]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]
Nicotine results in decreased expression of CDK4 mRNA; Nicotine results in decreased expression of CDK4 protein
CTD PMID:15231866 PMID:17135361 PMID:18805435 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
increases expression
ISO Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein]
Nicotine results in increased expression of CDK6 mRNA
CTD PMID:16949557 PMID:18805435 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions
increases expression
ISO Nicotine results in decreased expression of CDKN1A protein
Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein]
Nicotine results in increased expression of CDKN1A mRNA; Nicotine results in increased expression of CDKN1A protein
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1A protein]; Nicotine inhibits the reaction [Cisplatin results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [Gemcitabine results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein]
CTD PMID:16011614 PMID:16601104 PMID:18805435 PMID:20727180 PMID:30272249 More... NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression
multiple interactions
ISO Nicotine results in decreased expression of CDKN1B protein
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1B protein]; Nicotine results in increased expression of and results in increased stability of CDKN1B protein
CTD PMID:15231866 PMID:18805435 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein]
Nicotine results in increased expression of CDKN2A mRNA; Nicotine results in increased expression of CDKN2A protein
CTD PMID:32473187 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cds1 CDP-diacylglycerol synthase 1 increases splicing ISO Nicotine results in increased splicing of CDS1 mRNA alternative form CTD PMID:23825647 NCBI chr14:8,126,678...8,187,243
Ensembl chr14:7,820,351...7,882,681
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Nicotine results in increased expression of CEACAM1 mRNA CTD PMID:17997037 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
affects expression
increases expression
EXP
ISO
[Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPA protein
Nicotine affects the expression of CEBPA mRNA
Nicotine results in increased expression of CEBPA mRNA
CTD PMID:29617909 PMID:31622651 PMID:31972234 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of CEBPB mRNA
[Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPB mRNA
CTD PMID:18805435 PMID:29617909 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Celf6 CUGBP, Elav-like family member 6 increases expression EXP Nicotine results in increased expression of CELF6 mRNA CTD PMID:27782041 NCBI chr 8:68,870,902...68,901,863
Ensembl chr 8:59,975,088...60,005,041
JBrowse link
G Cenpe centromere protein E increases expression ISO Nicotine results in increased expression of CENPE mRNA CTD PMID:16949557 NCBI chr 2:226,310,970...226,369,636
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
G Cers6 ceramide synthase 6 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of CERS6 mRNA CTD PMID:28065790 NCBI chr 3:74,038,520...74,287,544
Ensembl chr 3:53,630,959...53,876,848
JBrowse link
G Cetn2 centrin 2 decreases expression ISO Nicotine results in decreased expression of CETN2 mRNA CTD PMID:17997037 NCBI chr  X:155,812,212...155,817,186
Ensembl chr  X:150,769,953...150,774,919
JBrowse link
G Cetn3 centrin 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CETN3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CETN3 mRNA] CTD PMID:20230807 NCBI chr 2:13,817,760...13,837,502
Ensembl chr 2:12,089,226...12,101,828
JBrowse link
G Cfap43 cilia and flagella associated protein 43 decreases expression ISO Nicotine results in decreased expression of CFAP43 mRNA CTD PMID:23825647 NCBI chr 1:256,566,558...256,653,816
Ensembl chr 1:246,625,262...246,712,443
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide increases expression ISO Nicotine results in increased expression of CGA mRNA CTD PMID:23825647 NCBI chr 5:54,283,109...54,295,464
Ensembl chr 5:49,487,068...49,499,191
JBrowse link
G Cgref1 cell growth regulator with EF hand domain 1 increases expression ISO Nicotine results in increased expression of CGREF1 mRNA CTD PMID:23825647 NCBI chr 6:31,151,795...31,163,801
Ensembl chr 6:25,431,799...25,443,852
JBrowse link
G Chat choline O-acetyltransferase multiple interactions
increases activity
decreases activity
EXP Nicotine inhibits the reaction [Vanadium results in decreased expression of CHAT protein]; Nicotine promotes the reaction [Bucladesine results in increased expression of CHAT protein]
Nicotine results in increased activity of CHAT protein
Nicotine results in decreased activity of CHAT protein
CTD PMID:20361958 PMID:21633116 PMID:22119111 PMID:30247698 NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Chd2 chromodomain helicase DNA binding protein 2 increases expression ISO Nicotine results in increased expression of CHD2 mRNA CTD PMID:16949557 NCBI chr 1:136,597,993...136,726,874
Ensembl chr 1:127,190,059...127,300,502
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form] CTD PMID:23907605 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Chga chromogranin A multiple interactions
increases activity
increases expression
ISO
EXP
CHGA protein alternative form inhibits the reaction [Nicotine results in increased activity of CHGA promoter]; Chlorisondamine inhibits the reaction [Nicotine results in increased activity of CHGA promoter]
Nicotine results in increased expression of CHGA mRNA
CTD PMID:1907749 PMID:12799369 NCBI chr 6:127,460,895...127,472,238
Ensembl chr 6:121,696,051...121,707,398
JBrowse link
G Chgb chromogranin B increases expression EXP Nicotine results in increased expression of CHGB mRNA; Nicotine results in increased expression of CHGB protein CTD PMID:1907749 NCBI chr 3:140,496,712...140,510,057
Ensembl chr 3:120,043,738...120,057,166
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions
affects binding
ISO PLAU inhibits the reaction [Nicotine binds to CHRNA1 protein] CTD PMID:19690163 NCBI chr 3:78,862,286...78,877,353
Ensembl chr 3:58,454,744...58,469,840
JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit increases expression EXP Nicotine results in increased expression of CHRNA10 mRNA CTD PMID:30959089 PMID:31846720 NCBI chr 1:165,898,932...165,905,348
Ensembl chr 1:156,487,279...156,491,476
JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit affects response to substance
multiple interactions
ISO CHRNA2 gene mutant form affects the susceptibility to Nicotine
Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]
CTD PMID:9454827 PMID:19383498 NCBI chr15:44,517,862...44,534,144
Ensembl chr15:40,342,317...40,358,601
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit decreases expression
increases activity
multiple interactions
increases expression
affects response to substance
ISO
EXP
Nicotine results in decreased expression of CHRNA3 mRNA
Nicotine results in increased activity of CHRNA3 protein
Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Nicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
Nicotine results in increased expression of CHRNA3 mRNA
CHRNA3 protein affects the susceptibility to Nicotine
CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]
CTD PMID:9454827 PMID:10336510 PMID:11600638 PMID:12628473 PMID:15275829 More... NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects binding
increases expression
decreases expression
multiple interactions
increases response to substance
affects response to substance
ISO
EXP
Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in increased expression of CHRNA4 mRNA; Nicotine results in increased expression of CHRNA4 protein
Nicotine results in decreased expression of CHRNA4 mRNA
Nicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]
1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of [CHRNA4 protein binds to CHRNB2 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of CHRNA4 mRNA]; imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; N-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased expression of [CHRNA4 protein binds to CHRNB2 protein]
[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with Nicotine] inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein]; cytisine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Nicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CHRNA4 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
CHRNA4 protein mutant form results in increased susceptibility to Nicotine
CHRNA4 gene polymorphism affects the susceptibility to Nicotine; CHRNA4 protein affects the susceptibility to Nicotine; CHRNA4 protein mutant form affects the susceptibility to Nicotine
[CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
CTD PMID:7756618 PMID:9336329 PMID:9454827 PMID:10336510 PMID:10377228 More... NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit increases response to substance
increases expression
affects response to substance
decreases expression
multiple interactions
ISO CHRNA5 gene polymorphism results in increased susceptibility to Nicotine
Nicotine results in increased expression of CHRNA5 mRNA
CHRNA5 gene polymorphism affects the susceptibility to Nicotine
Nicotine results in increased expression of CHRNA5 mRNA; Nicotine results in increased expression of CHRNA5 protein
Nicotine results in decreased expression of CHRNA5 mRNA
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; alpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; alpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of HIF1A protein]; CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of VEGFA protein]; CHRNA5 protein affects the reaction [Nicotine results in increased expression of and results in increased cleavage of CASP1 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased expression of NLRP3 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL18 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL1B protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]
CTD PMID:9495872 PMID:12628473 PMID:18450646 PMID:18519132 PMID:24793809 More... NCBI chr 8:64,265,879...64,294,233
Ensembl chr 8:55,369,794...55,398,146
JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit decreases expression
increases expression
multiple interactions
affects response to substance
ISO Nicotine results in decreased expression of CHRNA6 mRNA
Nicotine results in increased expression of CHRNA6 mRNA
Nicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]; Nicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]
CHRNA6 gene polymorphism affects the susceptibility to Nicotine
CTD PMID:10734154 PMID:12628473 PMID:17227438 PMID:29293602 PMID:30959089 NCBI chr16:71,400,615...71,407,315
Ensembl chr16:64,697,741...64,704,441
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases response to substance
increases expression
affects activity
increases activity
decreases expression
multiple interactions
affects response to substance
ISO
EXP
CHRNA7 protein mutant form results in increased susceptibility to Nicotine
Nicotine results in increased expression of CHRNA7 mRNA; Nicotine results in increased expression of CHRNA7 protein
Nicotine affects the activity of CHRNA7 protein
Nicotine results in increased activity of CHRNA7 protein
Nicotine results in decreased expression of CHRNA7 mRNA; Nicotine results in decreased expression of CHRNA7 protein
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which affects the susceptibility to Nicotine; [Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of CHRNA7 protein; [Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium; Nicotine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]; Nicotine inhibits the reaction [methyllycaconitine binds to CHRNA7 protein]; Nicotine results in increased expression of and results in increased phosphorylation of CHRNA7 protein
[Bungarotoxins results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine; [triethyl-(beta-4-stilbenoxyethyl)ammonium results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine
CHRNA7 gene polymorphism affects the susceptibility to Nicotine; CHRNA7 protein affects the susceptibility to Nicotine
Nicotine results in increased expression of CHRNA7; Nicotine results in increased expression of CHRNA7 mRNA; Nicotine results in increased expression of CHRNA7 protein
Nicotine results in increased activity of CHRNA7 protein; Nicotine results in increased activity of CHRNA7 protein mutant form
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium; Bungarotoxins inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; CHRNA7 affects the reaction [Nicotine results in decreased expression of SLBP protein]; CHRNA7 affects the reaction [Nicotine results in increased expression of CDK1 protein]; CHRNA7 affects the reaction [Nicotine results in increased expression of CSNK2A1 protein]; CHRNA7 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; MB327 analog promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; MB327 promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; MB327 promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]; methyllycaconitine promotes the reaction [[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium]; Nicotine binds to and results in increased activity of CHRNA7 protein; Nicotine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine results in increased expression of and results in increased phosphorylation of CHRNA7 protein; Pyridinium Compounds analog promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]
CTD PMID:9336329 PMID:9495872 PMID:10082212 PMID:10216184 PMID:10942032 More... NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit increases expression
multiple interactions
ISO Nicotine results in increased expression of CHRNA9 mRNA
[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of CHRNA9 protein
CTD PMID:29486207 PMID:30259641 PMID:30959089 PMID:31846720 NCBI chr14:42,588,948...42,595,669
Ensembl chr14:42,235,226...42,242,192
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
increases expression
decreases expression
affects binding
affects response to substance
ISO
EXP
[CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in increased expression of CHRNB2 mRNA
1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of [CHRNA4 protein binds to CHRNB2 protein]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; N-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]; Nicotine results in increased expression of [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in decreased expression of CHRNB2 mRNA
Nicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in increased expression of CHRNB2 mRNA; Nicotine results in increased expression of CHRNB2 protein
CHRNB2 protein affects the susceptibility to Nicotine
CHRNB2 promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; cytisine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]; Nicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]; Nicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]
CTD PMID:7756618 PMID:9336329 PMID:10336510 PMID:10377228 PMID:10945867 More... NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit increases expression EXP Nicotine results in increased expression of CHRNB3 mRNA CTD PMID:30959089 NCBI chr16:71,411,847...71,454,225
Ensembl chr16:64,714,169...64,751,360
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions
increases expression
increases activity
affects response to substance
ISO
EXP
Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]
Nicotine results in increased expression of CHRNB4 mRNA
Nicotine results in increased activity of CHRNB4 protein
Nicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
CHRNB4 protein affects the susceptibility to Nicotine
CTD PMID:9454827 PMID:11600638 PMID:15275829 PMID:15615518 PMID:19483072 More... NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Ciao1 cytosolic iron-sulfur assembly component 1 decreases expression EXP Nicotine results in decreased expression of CIAO1 mRNA CTD PMID:11478936 NCBI chr 3:134,913,639...134,919,244
Ensembl chr 3:114,458,655...114,467,009
JBrowse link
G Cib1 calcium and integrin binding 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CIB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CIB1 mRNA] CTD PMID:20230807 NCBI chr 1:143,587,591...143,593,153
Ensembl chr 1:134,178,331...134,213,423
JBrowse link
G Cidea cell death-inducing DFFA-like effector a decreases expression EXP Nicotine results in decreased expression of CIDEA mRNA CTD PMID:33091441 NCBI chr18:63,164,817...63,190,384
Ensembl chr18:60,894,874...60,920,481
JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO Nicotine results in increased expression of CIRBP mRNA CTD PMID:21955143 NCBI chr 7:10,184,515...10,189,623
Ensembl chr 7:9,424,178...9,538,818
JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CKMT1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CKMT1 mRNA] CTD PMID:20230807 NCBI chr 3:128,783,408...128,789,485
Ensembl chr 3:108,330,705...108,335,758
JBrowse link
G Ckmt2 creatine kinase, mitochondrial 2 decreases expression ISO Nicotine results in decreased expression of CKMT2 mRNA CTD PMID:16949557 NCBI chr 2:24,815,008...24,845,511
Ensembl chr 2:23,079,918...23,110,430
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B decreases expression ISO Nicotine results in decreased expression of CKS1B mRNA CTD PMID:18247414 NCBI chr 2:177,130,751...177,135,333
Ensembl chr 2:174,833,050...174,837,636
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 increases expression ISO Nicotine results in increased expression of CKS2 mRNA CTD PMID:16949557 NCBI chr17:13,722,360...13,727,519 JBrowse link
G Clca2 chloride channel accessory 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CLCA2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLCA2 mRNA] CTD PMID:20230807 NCBI chr 2:236,655,419...236,682,669
Ensembl chr 2:233,995,078...234,022,199
JBrowse link
G Clcc1 chloride channel CLIC-like 1 increases expression ISO Nicotine results in increased expression of CLCC1 mRNA CTD PMID:16949557 NCBI chr 2:198,984,455...199,015,015
Ensembl chr 2:196,296,393...196,326,913
JBrowse link
G Clcn3 chloride voltage-gated channel 3 increases expression ISO Nicotine results in increased expression of CLCN3 mRNA CTD PMID:16949557 NCBI chr16:34,138,004...34,210,984
Ensembl chr16:29,127,419...29,200,119
JBrowse link
G Cldn4 claudin 4 increases expression
decreases expression
ISO Nicotine results in increased expression of CLDN4 protein
Nicotine results in decreased expression of CLDN4 protein
CTD PMID:31783125 NCBI chr12:27,388,160...27,389,958
Ensembl chr12:21,751,331...21,753,436
JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression ISO Nicotine results in decreased expression of CLIC1 mRNA CTD PMID:16949557 NCBI chr20:3,769,522...3,778,367
Ensembl chr20:3,761,461...3,773,712
JBrowse link
G Clmp CXADR-like membrane protein increases expression ISO Nicotine results in increased expression of CLMP mRNA CTD PMID:23825647 NCBI chr 8:49,957,639...50,065,959
Ensembl chr 8:41,060,799...41,168,838
JBrowse link
G Clstn1 calsyntenin 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA] CTD PMID:20230807 NCBI chr 5:165,314,128...165,377,627
Ensembl chr 5:160,031,308...160,094,583
JBrowse link
G Cmtm5 CKLF-like MARVEL transmembrane domain containing 5 decreases expression ISO Nicotine results in decreased expression of CMTM5 mRNA CTD PMID:21955143 NCBI chr15:32,382,171...32,385,288
Ensembl chr15:28,412,624...28,415,287
JBrowse link
G Cnn2 calponin 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CNN2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CNN2 mRNA] CTD PMID:20230807 NCBI chr 7:10,363,141...10,370,312
Ensembl chr 7:9,712,516...9,719,656
JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance
increases expression
multiple interactions
ISO CNR1 protein affects the susceptibility to Nicotine
Nicotine results in increased expression of CNR1 mRNA
[rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to Nicotine
CTD PMID:12384171 PMID:16416159 PMID:21955143 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cntn1 contactin 1 decreases expression
increases expression
multiple interactions
ISO Nicotine results in decreased expression of CNTN1 mRNA
Nicotine results in increased expression of CNTN1 mRNA
alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]
CTD PMID:12588870 PMID:16949557 NCBI chr 7:125,142,638...125,440,397
Ensembl chr 7:123,372,792...123,558,541
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL1A1 mRNA; NGF protein affects the reaction [Nicotine results in increased expression of COL1A1 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL1A1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; Nicotine promotes the reaction [Thioacetamide results in increased expression of COL1A1]
Nicotine results in increased expression of COL1A1 mRNA; Nicotine results in increased expression of COL1A1 protein
CTD PMID:20230807 PMID:28440100 PMID:33082140 PMID:33640489 PMID:34153408 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP
ISO
Nicotine promotes the reaction [Arginine results in increased expression of COL1A2 protein]
Nicotine promotes the reaction [Quartz results in increased expression of COL1A2 protein]
CTD PMID:34153408 PMID:36868510 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of COL2A1 mRNA; Nicotine results in decreased expression of COL2A1 protein
NLRP3 protein affects the reaction [Nicotine results in decreased expression of COL2A1 mRNA]
CTD PMID:29660438 PMID:31299270 PMID:34245815 PMID:39098741 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of COL3A1 mRNA
Nicotine results in increased expression of COL3A1 mRNA; Nicotine results in increased expression of COL3A1 protein
Nicotine promotes the reaction [Arginine results in increased expression of COL3A1 protein]
NGF protein affects the reaction [Nicotine results in increased expression of COL3A1 mRNA]
CTD PMID:33082140 PMID:34153408 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Col6a1 collagen type VI alpha 1 chain multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL6A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL6A1 mRNA] CTD PMID:20230807 NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Cort cortistatin affects expression
decreases expression
EXP Nicotine affects the expression of CORT protein
Nicotine results in decreased expression of CORT protein
CTD PMID:22975262 PMID:26776438 PMID:28555334 NCBI chr 5:164,843,682...164,845,796 JBrowse link
G Cox7a2l cytochrome c oxidase subunit 7A2 like multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of COX7A2L mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7A2L mRNA] CTD PMID:20230807 NCBI chr 6:16,936,574...16,950,797
Ensembl chr 6:11,184,285...11,198,273
JBrowse link
G Cox7c cytochrome c oxidase subunit 7C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7C mRNA] CTD PMID:20230807 NCBI chr 2:18,577,145...18,579,170
Ensembl chr 2:16,840,837...16,843,760
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 decreases expression ISO Nicotine results in decreased expression of CRABP2 mRNA CTD PMID:16949557 NCBI chr 2:175,714,862...175,719,208
Ensembl chr 2:173,416,857...173,421,379
JBrowse link
G Crct1 cysteine-rich C-terminal 1 increases expression ISO Nicotine results in increased expression of CRCT1 mRNA CTD PMID:23825647 NCBI chr 2:181,329,392...181,330,877
Ensembl chr 2:178,634,092...178,634,394
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases expression
increases phosphorylation
decreases expression
ISO
EXP
CREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA]
Nicotine results in increased expression of CREB1 mRNA
Nicotine results in increased phosphorylation of CREB1 protein
CREB1 protein promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; Excitatory Amino Acid Antagonists inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; KN 93 inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Nicotine promotes the reaction [CREB1 protein modified form binds to RYR2 promoter]; Nifedipine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Ryanodine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]
Nicotine results in decreased expression of CREB1 mRNA
CTD PMID:18247414 PMID:21113126 PMID:25847246 PMID:31945395 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Creb3 cAMP responsive element binding protein 3 increases expression ISO Nicotine results in increased expression of CREB3 mRNA CTD PMID:31945395 NCBI chr 5:62,613,652...62,619,019
Ensembl chr 5:57,817,832...57,824,390
JBrowse link
G Creb5 cAMP responsive element binding protein 5 increases expression ISO Nicotine results in increased expression of CREB5 mRNA CTD PMID:31945395 NCBI chr 4:83,723,587...84,124,786
Ensembl chr 4:82,393,730...82,790,325
JBrowse link
G Crebbp CREB binding protein increases expression ISO Nicotine results in increased expression of CREBBP mRNA CTD PMID:31945395 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Crh corticotropin releasing hormone decreases expression
increases expression
EXP
ISO
Nicotine results in decreased expression of CRH mRNA; Nicotine results in decreased expression of CRH protein
Nicotine results in increased expression of CRH protein
CTD PMID:21955143 PMID:22265867 PMID:23623838 PMID:28555334 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Cryab crystallin, alpha B decreases expression ISO Nicotine results in decreased expression of CRYAB mRNA CTD PMID:21955143 NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Cs citrate synthase multiple interactions ISO [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA CTD PMID:33091441 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:758,345...791,421
JBrowse link
G Csdc2 cold shock domain containing C2 decreases expression ISO Nicotine results in decreased expression of CSDC2 mRNA CTD PMID:21955143 NCBI chr 7:115,332,134...115,346,599
Ensembl chr 7:113,451,998...113,466,463
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases secretion
ISO Nicotine results in increased expression of and results in increased secretion of CSF2 protein; Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein] CTD PMID:9606035 PMID:18082304 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Csn2 casein beta multiple interactions ISO Nicotine results in decreased expression of and results in decreased secretion of CSN2 protein CTD PMID:31783125 NCBI chr14:20,601,824...20,609,061
Ensembl chr14:20,322,581...20,329,817
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of CSNK2A1 protein
CHRNA7 affects the reaction [Nicotine results in increased expression of CSNK2A1 protein]; CSNK2A1 affects the reaction [Nicotine results in decreased expression of SLBP protein]; CSNK2A1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]
CTD PMID:35929799 NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:140,709,991...140,756,696
JBrowse link
G Cst3 cystatin C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CST3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CST3 mRNA] CTD PMID:20230807 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:136,336,920...136,340,822
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
ISO Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of CTNNB1 mRNA]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of CTNNB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]
Nicotine results in increased expression of CTNNB1 mRNA; Nicotine results in increased expression of CTNNB1 protein
CTD PMID:33640489 PMID:35411647 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSB mRNA] CTD PMID:20230807 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsh cathepsin H increases expression ISO Nicotine results in increased expression of CTSH mRNA CTD PMID:23825647 NCBI chr 8:99,488,756...99,507,639
Ensembl chr 8:90,608,941...90,627,824
JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CTSL mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA] CTD PMID:20230807 NCBI chr17:770,104...776,266
Ensembl chr17:764,309...770,548
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Nicotine results in decreased expression of CXCL2 mRNA CTD PMID:18247414 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression
decreases secretion
increases expression
ISO Nicotine results in decreased expression of CXCL1 mRNA
Nicotine results in decreased secretion of CXCL1 protein
Nicotine results in increased expression of CXCL1 protein
CTD PMID:16254210 PMID:22093924 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression
increases expression
ISO Nicotine results in decreased expression of CXCR2 mRNA
Nicotine results in increased expression of CXCR2 mRNA
CTD PMID:18247414 PMID:20457658 NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO Nicotine results in increased expression of CXCR3 mRNA CTD PMID:20457658 NCBI chr  X:70,884,293...70,886,944
Ensembl chr  X:66,844,318...66,846,969
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions
increases expression
ISO [Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein]
Nicotine results in increased expression of CXCR4 mRNA; Nicotine results in increased expression of CXCR4 protein
CTD PMID:20457658 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression
increases secretion
affects localization
decreases secretion
ISO
EXP
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of CYCS protein]
Nicotine results in increased expression of CYCS protein
Nicotine results in increased secretion of CYCS protein
Folic Acid inhibits the reaction [Nicotine results in increased expression of CYCS protein]; Nicotine inhibits the reaction [[Calcium co-treated with Phosphates] affects the localization of CYCS protein]
Nicotine affects the localization of CYCS protein
Nicotine results in decreased secretion of CYCS protein
CTD PMID:11701223 PMID:15985439 PMID:18203686 PMID:29972271 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
decreases activity
multiple interactions
ISO
EXP
Nicotine results in decreased expression of CYP11A1 mRNA; Nicotine results in decreased expression of CYP11A1 protein
Nicotine results in decreased activity of CYP11A1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYP11A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein]
CTD PMID:20230807 PMID:21971485 PMID:22265867 PMID:24709674 PMID:28986172 More... NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression EXP Nicotine results in decreased expression of CYP11B1 mRNA CTD PMID:24709674 NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:106,838,590...106,845,004
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO
EXP
Nicotine results in decreased expression of CYP17A1 mRNA
Nicotine results in decreased expression of CYP17A1 mRNA; Nicotine results in decreased expression of CYP17A1 protein
CTD PMID:24709674 PMID:27782041 PMID:28986172 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression
multiple interactions
increases activity
ISO
EXP
Nicotine results in decreased expression of CYP19A1 mRNA; Nicotine results in decreased expression of CYP19A1 protein
bisphenol A promotes the reaction [Nicotine results in decreased expression of CYP19A1 protein]
Nicotine results in increased activity of CYP19A1 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein]
CTD PMID:30959089 PMID:32113805 PMID:35577041 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of CYP1A1 mRNA; Nicotine results in increased expression of CYP1A1 protein
Nicotine results in decreased expression of CYP1A1 protein
bisphenol A promotes the reaction [Nicotine results in decreased expression of CYP1A1 protein]
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CYP1A1 protein]; CYP1A1 protein affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; SB 203580 inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; SR 11302 inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]
CTD PMID:11849738 PMID:22498344 PMID:34171359 PMID:35577041 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression
decreases activity
ISO
EXP
Nicotine results in increased expression of CYP1A2 protein
Nicotine results in decreased expression of CYP1A2 mRNA
Nicotine results in decreased activity of CYP1A2 protein
CTD PMID:11849738 PMID:15916432 PMID:26463278 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression
multiple interactions
EXP Nicotine results in decreased expression of CYP1B1 protein
bisphenol A promotes the reaction [Nicotine results in decreased expression of CYP1B1 protein]
CTD PMID:35577041 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression ISO Nicotine results in decreased expression of CYP26A1 mRNA; Nicotine results in decreased expression of CYP26A1 protein CTD PMID:21371177 NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression
multiple interactions
decreases activity
increases metabolic processing
EXP
ISO
Nicotine results in increased expression of CYP2A1 mRNA
Nicotine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone]; Nicotine inhibits the reaction [CYP2A13 protein results in increased susceptibility to Aflatoxin B1]
Nicotine results in decreased activity of CYP2A13 protein
CYP2A13 protein results in increased metabolism of Nicotine
CTD PMID:22743290 PMID:22934830 PMID:27567546 NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 increases expression
increases hydroxylation
EXP Nicotine results in increased expression of CYP2A2 mRNA
CYP2A6 protein results in increased hydroxylation of Nicotine
CTD PMID:12919726 PMID:22934830 NCBI chr 1:91,391,492...91,417,158
Ensembl chr 1:82,263,833...82,289,487
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression EXP Nicotine results in increased expression of CYP2A3 mRNA CTD PMID:14972772 PMID:22934830 NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
increases metabolic processing
EXP [Nicotine co-treated with 2,2',3,5',6-pentachlorobiphenyl] results in increased expression of CYP2B1 mRNA; [Nicotine results in increased expression of CYP2B1 protein] which results in increased abundance of Cotinine; [Nicotine results in increased expression of CYP2B1 protein] which results in increased metabolism of Nicotine; Nicotine results in increased expression of and results in increased activity of CYP2B1 protein
Nicotine results in increased expression of CYP2B1 mRNA; Nicotine results in increased expression of CYP2B1 protein
CYP2B1 protein results in increased metabolism of Nicotine
CTD PMID:10799646 PMID:14972772 PMID:20599831 PMID:26463278 NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing
increases oxidation
affects oxidation
multiple interactions
ISO CYP2B6 protein results in increased metabolism of Nicotine
CYP2B6 protein results in increased oxidation of Nicotine
CYP2B6 gene polymorphism affects the oxidation of Nicotine
CYP2B6 gene polymorphism affects the reaction [CYP2A6 protein results in increased metabolism of Nicotine]
CTD PMID:12488541 PMID:18004205 PMID:30906561 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases expression
ISO Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 mRNA]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 protein]
Nicotine results in increased expression of CYP2D22 mRNA; Nicotine results in increased expression of CYP2D22 protein
CTD PMID:19594327 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP Nicotine results in increased expression of CYP2E1 protein CTD PMID:16434548 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP
ISO
[Nicotine co-treated with 2,2',3,5',6-pentachlorobiphenyl] results in increased expression of CYP3A2 mRNA
[Nicotine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA
CTD PMID:12851153 PMID:26463278 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases expression ISO Nicotine results in increased expression of CYP4F3 mRNA CTD PMID:23825647 NCBI chr16:17,797,558...17,838,958
Ensembl chr16:17,707,317...17,804,940
JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions
increases expression
ISO [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA] CTD PMID:17498763 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Dcaf16 DDB1 and CUL4 associated factor 16 increases expression ISO Nicotine results in increased expression of DCAF16 mRNA CTD PMID:16949557 NCBI chr14:69,662,173...69,662,557 JBrowse link
G Ddb1 damage-specific DNA binding protein 1 decreases expression ISO Nicotine results in decreased expression of DDB1 mRNA CTD PMID:16949557 NCBI chr 1:216,677,810...216,703,605
Ensembl chr 1:207,252,890...207,278,676
JBrowse link
G Ddhd2 DDHD domain containing 2 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of DDHD2 mRNA CTD PMID:28065790 NCBI chr16:73,022,136...73,051,746
Ensembl chr16:66,319,466...66,349,023
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO
EXP
Nicotine inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA]
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DDIT3 protein]
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of DDIT3 protein]
CTD PMID:11592233 PMID:28082123 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Nicotine results in increased expression of DDIT4 mRNA CTD PMID:17456735 PMID:23825647 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Ddx17 DEAD-box helicase 17 increases expression ISO Nicotine results in increased expression of DDX17 mRNA CTD PMID:16949557 NCBI chr 7:112,971,522...112,989,747
Ensembl chr 7:111,089,445...111,109,193
JBrowse link
G Dedd death effector domain-containing decreases expression ISO Nicotine results in decreased expression of DEDD mRNA CTD PMID:18247414 NCBI chr13:86,286,341...86,301,789
Ensembl chr13:83,756,108...83,769,332
JBrowse link
G Defb23 defensin beta 23 decreases expression ISO Nicotine results in decreased expression of DEFB129 mRNA CTD PMID:23825647 NCBI chr 3:161,383,615...161,390,685
Ensembl chr 3:140,923,474...140,927,686
JBrowse link
G Dffb DNA fragmentation factor subunit beta decreases expression ISO Nicotine results in decreased expression of DFFB mRNA CTD PMID:18247414 NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:164,522,463...164,534,628
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO Nicotine results in decreased expression of DHCR24 mRNA CTD PMID:21955143 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Dhfr dihydrofolate reductase multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] CTD PMID:12588870 NCBI chr 2:25,320,895...25,346,004
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Dhps deoxyhypusine synthase decreases expression ISO Nicotine results in decreased expression of DHPS mRNA CTD PMID:16949557 NCBI chr19:39,987,328...39,991,418
Ensembl chr19:23,082,448...23,086,881
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases expression ISO Nicotine results in increased expression of DHRS3 mRNA CTD PMID:23825647 NCBI chr 5:162,031,853...162,065,655
Ensembl chr 5:156,747,962...156,782,417
JBrowse link
G Dhx36 DEAH-box helicase 36 increases expression ISO Nicotine results in increased expression of DHX36 mRNA CTD PMID:17997037 NCBI chr 2:149,006,089...149,044,192
Ensembl chr 2:146,856,469...146,894,572
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
decreases methylation
ISO
EXP
Nicotine results in decreased expression of DLG4 mRNA
Nicotine results in decreased methylation of DLG4 gene
CTD PMID:21955143 PMID:28555334 PMID:32994467 NCBI chr10:55,239,397...55,267,780
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJA1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJA1 mRNA] CTD PMID:20230807 NCBI chr 5:60,638,404...60,649,315
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJB9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJB9 mRNA] CTD PMID:20230807 NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:61,269,913...61,275,063
JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal decreases expression ISO Nicotine results in decreased expression of DNASE2 mRNA CTD PMID:18247414 NCBI chr19:40,149,505...40,152,225
Ensembl chr19:23,244,664...23,247,376
JBrowse link
G Dnm1l dynamin 1-like increases expression ISO Nicotine results in increased expression of DNM1L protein CTD PMID:21554491 NCBI chr11:98,084,049...98,135,663
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression
multiple interactions
EXP Nicotine results in decreased expression of DNMT1 mRNA
Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in decreased expression of DNMT1 mRNA]
CTD PMID:28555334 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA] CTD PMID:20230807 NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:46,962,243...47,043,901
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions
decreases expression
EXP
ISO
[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Nicotine
Nicotine results in decreased expression of DRD1 mRNA
CTD PMID:1833784 PMID:21955143 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
decreases response to substance
EXP [Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Nicotine
DRD2 mRNA results in decreased susceptibility to Nicotine
CTD PMID:1833784 PMID:24239691 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 increases expression ISO Nicotine results in increased expression of DRD3 protein CTD PMID:31945395 NCBI chr11:70,385,586...70,437,793
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Dtymk deoxythymidylate kinase decreases expression ISO Nicotine results in decreased expression of DTYMK mRNA CTD PMID:16949557 NCBI chr 9:101,762,899...101,771,733
Ensembl chr 9:94,315,552...94,324,870
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Nicotine results in increased expression of DUSP1 mRNA CTD PMID:17456735 NCBI chr10:17,184,853...17,187,646 JBrowse link
G Dusp11 dual specificity phosphatase 11 decreases expression ISO Nicotine results in decreased expression of DUSP11 mRNA CTD PMID:17456735 NCBI chr 4:119,928,533...119,942,643
Ensembl chr 4:118,368,053...118,385,181
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO Nicotine results in increased expression of DUSP6 mRNA CTD PMID:17456735 PMID:21955143 NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Dvl2 dishevelled segment polarity protein 2 decreases expression
increases expression
multiple interactions
ISO Nicotine results in decreased expression of DVL2 mRNA
Nicotine results in increased expression of DVL2 mRNA; Nicotine results in increased expression of DVL2 protein
Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of DVL2 mRNA]; Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of DVL2 protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of DVL2 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of DVL2 protein]
CTD PMID:16949557 PMID:33640489 PMID:35411647 NCBI chr10:55,222,245...55,231,506
Ensembl chr10:54,723,411...54,732,820
JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 increases expression ISO Nicotine results in increased expression of DYNC1LI2 mRNA CTD PMID:16949557 NCBI chr19:538,207...561,110
Ensembl chr19:531,812...554,670
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions
increases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of E2F1 protein]; Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter] CTD PMID:16601104 PMID:16862215 PMID:20061081 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G E2f2 E2F transcription factor 2 multiple interactions ISO Nicotine promotes the reaction [E2F2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:148,399,642...148,421,217
JBrowse link
G E2f3 E2F transcription factor 3 multiple interactions ISO Nicotine promotes the reaction [E2F3 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,601,830...34,676,253
JBrowse link
G E2f4 E2F transcription factor 4 multiple interactions ISO Nicotine inhibits the reaction [E2F4 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr19:50,084,335...50,091,731
Ensembl chr19:33,174,410...33,181,806
JBrowse link
G E2f5 E2F transcription factor 5 multiple interactions ISO Nicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr 2:88,718,567...88,734,143
Ensembl chr 2:86,997,332...87,012,990
JBrowse link
G Ebf2 EBF transcription factor 2 increases expression EXP Nicotine results in increased expression of EBF2 mRNA CTD PMID:35026373 NCBI chr15:45,610,949...45,809,828
Ensembl chr15:41,435,509...41,634,403
JBrowse link
G Ecm1 extracellular matrix protein 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ECM1 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ECM1 mRNA] CTD PMID:20230807 NCBI chr 2:185,976,439...185,981,656
Ensembl chr 2:183,287,322...183,292,671
JBrowse link
G Edn1 endothelin 1 multiple interactions
increases expression
ISO MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of EDN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]
Nicotine results in increased expression of EDN1 mRNA; Nicotine results in increased expression of EDN1 protein
CTD PMID:33082140 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednra endothelin receptor type A decreases expression ISO Nicotine results in decreased expression of EDNRA mRNA CTD PMID:18247414 NCBI chr19:47,137,360...47,207,961
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Ednrb endothelin receptor type B increases activity EXP Nicotine results in increased activity of EDNRB protein CTD PMID:21316381 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of EEF2 protein modified form
[Nicotine results in increased expression of UBA2 protein] which results in increased sumoylation of EEF2 protein
CTD PMID:21554491 NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:8,533,116...8,559,183
JBrowse link
G Efhd1 EF-hand domain family, member D1 decreases expression ISO Nicotine results in decreased expression of EFHD1 mRNA CTD PMID:21955143 NCBI chr 9:95,386,155...95,432,800
Ensembl chr 9:87,938,284...87,984,917
JBrowse link
G Efna2 ephrin A2 increases expression ISO Nicotine results in increased expression of EFNA2 mRNA CTD PMID:23825647 NCBI chr 7:10,167,091...10,177,719
Ensembl chr 7:9,516,429...9,527,061
JBrowse link
G Efnb3 ephrin B3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EFNB3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EFNB3 mRNA] CTD PMID:20230807 NCBI chr10:54,773,282...54,780,727
Ensembl chr10:54,274,506...54,280,471
JBrowse link
G Egfr epidermal growth factor receptor decreases expression
increases phosphorylation
multiple interactions
EXP
ISO
Nicotine results in decreased expression of EGFR mRNA
Nicotine results in increased phosphorylation of EGFR protein
AG 1879 inhibits the reaction [Nicotine results in increased phosphorylation of EGFR protein]
CTD PMID:11478936 PMID:14569062 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 increases expression
decreases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of EGR1 mRNA; Nicotine results in increased expression of EGR1 protein
Nicotine results in decreased expression of EGR1 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EGR1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EGR1 mRNA]
[triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]] which results in decreased expression of FGF2 mRNA; EGR1 protein inhibits the reaction [triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 protein]; Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of EGR1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein]
CTD PMID:17456735 PMID:17997037 PMID:20230807 PMID:21955143 PMID:22198237 More... NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr2 early growth response 2 increases expression ISO Nicotine results in increased expression of EGR2 mRNA CTD PMID:17456735 NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,051,277...21,055,562
JBrowse link
G Egr3 early growth response 3 decreases expression ISO Nicotine results in decreased expression of EGR3 mRNA CTD PMID:21955143 NCBI chr15:51,560,482...51,565,778
Ensembl chr15:45,150,567...45,154,627
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 increases expression ISO Nicotine results in increased expression of EIF2AK2 mRNA CTD PMID:16949557 NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
EXP Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein]; ursodoxicoltaurine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26803847 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B subunit delta multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF2B4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF2B4 mRNA] CTD PMID:20230807 NCBI chr 6:30,903,148...30,908,803
Ensembl chr 6:25,183,186...25,188,829
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP Nicotine results in increased phosphorylation of EIF2S1 protein CTD PMID:26803847 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA]
EIF4E protein affects the reaction [Nicotine results in increased expression of BCL2 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of CCND1 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of MYC protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of VEGFA protein]; Nicotine promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]
CTD PMID:20230807 PMID:30836163 NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif4e3 eukaryotic translation initiation factor 4E family member 3 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of EIF4E3 mRNA CTD PMID:37951547 NCBI chr 4:133,709,802...133,858,398
Ensembl chr 4:132,258,502...132,301,808
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein; Nicotine promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]; Nicotine results in increased expression of and results in increased phosphorylation of EIF4EBP1 protein CTD PMID:12511591 PMID:30836163 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EIF5 mRNA] CTD PMID:20230807 NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:130,589,143...130,597,656
JBrowse link
G Elk1 ETS transcription factor ELK1 increases phosphorylation
multiple interactions
EXP
ISO
Nicotine results in increased phosphorylation of ELK1 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein]
CTD PMID:29486207 NCBI chr  X:3,692,367...3,709,252
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Emc3 ER membrane protein complex subunit 3 decreases expression ISO Nicotine results in decreased expression of EMC3 mRNA CTD PMID:17997037 NCBI chr 4:148,218,686...148,234,595
Ensembl chr 4:146,663,067...146,679,029
JBrowse link
G Emcn endomucin increases expression ISO Nicotine results in increased expression of EMCN mRNA CTD PMID:17456735 NCBI chr 2:228,564,445...228,644,370
Ensembl chr 2:225,891,100...225,970,929
JBrowse link
G Eml4 EMAP like 4 multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA]; Mecamylamine promotes the reaction [Nicotine results in decreased expression of EML4 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA] CTD PMID:12588870 NCBI chr 6:16,972,054...17,087,365
Ensembl chr 6:11,219,566...11,334,879
JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Nicotine results in increased expression of EMP1 mRNA CTD PMID:23825647 NCBI chr 4:169,931,537...169,964,366
Ensembl chr 4:168,212,861...168,232,904
JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression ISO Nicotine results in decreased expression of ENC1 mRNA CTD PMID:17997037 NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:28,550,464...28,562,713
JBrowse link
G Eng endoglin decreases expression ISO Nicotine results in decreased expression of ENG mRNA CTD PMID:17456735 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Eno1 enolase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA] CTD PMID:20230807 NCBI chr 5:166,002,867...166,014,252
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336
JBrowse link
G Entpd3 ectonucleoside triphosphate diphosphohydrolase 3 increases expression ISO Nicotine results in increased expression of ENTPD3 mRNA CTD PMID:23825647 NCBI chr 8:129,124,540...129,155,528
Ensembl chr 8:120,247,121...120,277,943
JBrowse link
G Epha3 Eph receptor A3 decreases expression ISO Nicotine results in decreased expression of EPHA3 mRNA CTD PMID:18247414 NCBI chr11:14,585,041...14,920,721
Ensembl chr11:1,140,985...1,473,900
JBrowse link
G Ephb3 Eph receptor B3 decreases expression ISO Nicotine results in decreased expression of EPHB3 mRNA CTD PMID:18247414 NCBI chr11:93,345,098...93,363,775
Ensembl chr11:79,840,668...79,859,370
JBrowse link
G Epo erythropoietin increases expression ISO Nicotine results in increased expression of EPO mRNA CTD PMID:18247414 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA] CTD PMID:20230807 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Erp44 endoplasmic reticulum protein 44 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ERP44 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERP44 mRNA] CTD PMID:20230807 NCBI chr 5:67,313,245...67,406,207
Ensembl chr 5:62,516,551...62,610,761
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 increases expression ISO Nicotine results in increased expression of ERRFI1 mRNA CTD PMID:17456735 NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:161,323,998...161,337,282
JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Nicotine results in decreased expression of ESR1 mRNA CTD PMID:27552315 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Etfa electron transfer flavoprotein subunit alpha multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ETFA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ETFA mRNA] CTD PMID:20230807 NCBI chr 8:64,731,192...64,787,965
Ensembl chr 8:55,835,134...55,891,969
JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression ISO Nicotine results in decreased expression of ETFB mRNA CTD PMID:17997037 NCBI chr 1:102,988,499...103,002,663
Ensembl chr 1:93,851,858...93,866,068
JBrowse link
G Ezr ezrin multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EZR mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA]
Nicotine results in increased expression of EZR mRNA
CTD PMID:18247414 PMID:20230807 NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G F2 coagulation factor II, thrombin increases expression ISO Nicotine results in increased expression of F2 mRNA CTD PMID:18805435 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 increases expression EXP Nicotine results in increased expression of F2RL2 mRNA CTD PMID:27782041 NCBI chr 2:28,706,766...28,711,808
Ensembl chr 2:26,972,054...26,977,098
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Nicotine results in increased expression of F3 mRNA CTD PMID:17997037 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fah fumarylacetoacetate hydrolase increases expression ISO Nicotine results in increased expression of FAH mRNA CTD PMID:23825647 NCBI chr 1:147,957,931...147,980,708
Ensembl chr 1:138,548,834...138,571,505
JBrowse link
G Fam107a family with sequence similarity 107, member A decreases expression ISO Nicotine results in decreased expression of FAM107A mRNA CTD PMID:21955143 NCBI chr15:19,038,726...19,060,644
Ensembl chr15:16,607,205...16,630,396
JBrowse link
G Fam120a family with sequence similarity 120 member A decreases expression ISO Nicotine results in decreased expression of FAM120A mRNA CTD PMID:17997037 NCBI chr17:15,890,151...15,981,337
Ensembl chr17:15,684,233...15,774,964
JBrowse link
G Fam83f family with sequence similarity 83, member F increases expression ISO Nicotine results in increased expression of FAM83F mRNA CTD PMID:23825647 NCBI chr 7:114,091,356...114,120,640
Ensembl chr 7:112,211,164...112,240,452
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO
EXP
Nicotine results in increased expression of FAS mRNA; Nicotine results in increased expression of FAS protein CTD PMID:18203686 PMID:20383341 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand affects expression
increases expression
EXP
ISO
Nicotine affects the expression of FASLG mRNA
Nicotine results in increased expression of FASLG mRNA; Nicotine results in increased expression of FASLG protein
Nicotine results in increased expression of FASLG protein alternative form
CTD PMID:18203686 PMID:18247414 PMID:19896492 PMID:20383341 PMID:20426880 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase increases expression
affects expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of FASN mRNA; Nicotine results in increased expression of FASN protein
Nicotine affects the expression of FASN mRNA
Nicotine promotes the reaction [NR1H3 protein binds to FASN promoter]
CTD PMID:24368177 PMID:29155039 PMID:31622651 PMID:31972234 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fat1 FAT atypical cadherin 1 increases expression ISO Nicotine results in increased expression of FAT1 mRNA CTD PMID:16949557 NCBI chr16:53,909,759...54,029,175
Ensembl chr16:47,177,248...47,296,107
JBrowse link
G Fat2 FAT atypical cadherin 2 increases expression ISO Nicotine results in increased expression of FAT2 mRNA CTD PMID:23825647 NCBI chr10:39,864,765...39,957,027
Ensembl chr10:39,364,073...39,456,216
JBrowse link
G Fbn1 fibrillin 1 increases expression ISO Nicotine results in increased expression of FBN1 mRNA CTD PMID:17456735 NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fbxl12 F-box and leucine-rich repeat protein 12 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FBXL12 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FBXL12 mRNA] CTD PMID:20230807 NCBI chr 8:27,453,042...27,459,136
Ensembl chr 8:19,160,352...19,183,607
JBrowse link
G Fbxw5 F-box and WD repeat domain containing 5 decreases expression ISO Nicotine results in decreased expression of FBXW5 mRNA CTD PMID:17997037 NCBI chr 3:28,720,670...28,725,237
Ensembl chr 3:8,322,543...8,327,092
JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 increases expression
multiple interactions
decreases expression
ISO Nicotine results in increased expression of FEZ1 mRNA
alpha-cobratoxin promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA alternative form]; Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA]
CTD PMID:12588870 NCBI chr 8:44,733,288...44,778,519
Ensembl chr 8:36,544,535...36,589,683
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression
decreases expression
increases secretion
ISO
EXP
[triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]] which results in decreased expression of FGF2 mRNA; EGR1 protein inhibits the reaction [triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]]; Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]
Nicotine results in increased expression of FGF2 mRNA; Nicotine results in increased expression of FGF2 protein
Mecamylamine inhibits the reaction [Nicotine results in increased expression of FGF2 mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of FGF2 mRNA]
Nicotine results in decreased expression of FGF2 protein
CTD PMID:9503263 PMID:9832142 PMID:14732461 PMID:15465631 PMID:16365874 More... NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO Nicotine promotes the reaction [Quartz results in increased expression of FGF7 protein] CTD PMID:36868510 NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:113,281,283...113,332,929
JBrowse link
G Flrt2 fibronectin leucine rich transmembrane protein 2 increases expression ISO Nicotine results in increased expression of FLRT2 mRNA CTD PMID:23825647 NCBI chr 6:120,507,998...120,603,133
Ensembl chr 6:114,777,599...114,872,785
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO Nicotine results in decreased expression of FLT3 mRNA CTD PMID:18247414 NCBI chr12:12,660,035...12,735,584
Ensembl chr12:7,623,930...7,699,474
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of Nicotine CTD PMID:12504349 NCBI chr13:77,838,899...77,868,869
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Fn1 fibronectin 1 decreases expression
increases expression
multiple interactions
ISO Nicotine results in decreased expression of FN1 mRNA
Nicotine results in increased expression of FN1 mRNA; Nicotine results in increased expression of FN1 protein
MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of FN1 mRNA]; Nicotine promotes the reaction [Quartz results in increased expression of FN1 protein]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]
CTD PMID:18247414 PMID:18844224 PMID:33082140 PMID:36868510 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Folr1 folate receptor alpha increases expression ISO Nicotine results in increased expression of FOLR1 mRNA CTD PMID:19616087 NCBI chr 1:165,631,462...165,650,430
Ensembl chr 1:156,219,460...156,230,667
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation
affects expression
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased expression of FOS; Nicotine results in increased expression of FOS mRNA; Nicotine results in increased expression of FOS protein
Nicotine results in increased phosphorylation of FOS protein
Nicotine deficiency affects the expression of FOS protein
Acetaldehyde promotes the reaction [Nicotine results in increased expression of FOS mRNA]; Saponins inhibits the reaction [Nicotine results in increased expression of FOS protein]
Nicotine results in decreased expression of FOS mRNA
[U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; SB 203580 inhibits the reaction [Nicotine results in increased phosphorylation of FOS protein]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS]
CTD PMID:11425648 PMID:15857624 PMID:16251992 PMID:16690037 PMID:17003101 More... NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO
EXP
Nicotine results in increased expression of FOSB mRNA
Nicotine results in increased expression of FOSB protein
CTD PMID:16949557 PMID:17324382 PMID:17456735 NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein CTD PMID:12511591 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Foxp1 forkhead box P1 decreases expression ISO Nicotine results in decreased expression of FOXP1 mRNA CTD PMID:21955143 NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:131,564,756...132,112,258
JBrowse link
G Foxp3 forkhead box P3 decreases expression ISO Nicotine results in decreased expression of FOXP3 protein CTD PMID:31629012 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression ISO Nicotine results in decreased expression of SNL mRNA CTD PMID:18247414 NCBI chr12:16,710,601...16,723,734
Ensembl chr12:11,597,048...11,610,211
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Nicotine results in decreased expression of FSHB mRNA; Nicotine results in decreased expression of FSHB protein CTD PMID:20498001 PMID:28986172 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Fxyd1 FXYD domain-containing ion transport regulator 1 increases expression ISO Nicotine results in increased expression of FXYD1 mRNA CTD PMID:17997037 NCBI chr 1:95,414,556...95,418,645
Ensembl chr 1:86,287,165...86,291,278
JBrowse link
G Fxyd7 FXYD domain-containing ion transport regulator 7 decreases expression ISO Nicotine results in decreased expression of FXYD7 mRNA CTD PMID:21955143 NCBI chr 1:95,405,071...95,414,407
Ensembl chr 1:86,277,678...86,286,954
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO LCK protein promotes the reaction [Nicotine results in increased phosphorylation of and results in increased activity of FYN protein]; Nicotine results in increased phosphorylation of and results in increased activity of FYN protein CTD PMID:17709503 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:42,766,369...42,959,911
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP Nicotine results in decreased activity of G6PD protein CTD PMID:20498001 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gab1 GRB2-associated binding protein 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GAB1 mRNA] CTD PMID:20230807 NCBI chr19:44,035,693...44,143,617
Ensembl chr19:27,131,262...27,239,236
JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 increases expression EXP Nicotine results in increased expression of GABRA3 mRNA CTD PMID:28339662 NCBI chr  X:155,301,979...155,543,870
Ensembl chr  X:150,261,607...150,501,559
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 increases expression EXP Nicotine results in increased expression of GABRA5 mRNA CTD PMID:28339662 NCBI chr 1:117,404,446...117,517,424
Ensembl chr 1:108,268,776...108,380,917
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 increases expression EXP Nicotine results in increased expression of GABRA6 mRNA CTD PMID:28339662 NCBI chr10:27,311,965...27,327,337
Ensembl chr10:26,810,423...26,825,769
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression ISO Nicotine results in increased expression of GABRG2 mRNA CTD PMID:21955143 NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression
multiple interactions
decreases methylation
EXP Nicotine results in increased expression of GAD1 mRNA; Nicotine results in increased expression of GAD1 protein
Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of GAD1 mRNA]
Nicotine results in decreased methylation of GAD1 promoter
CTD PMID:18312583 PMID:28555334 NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gad2 glutamate decarboxylase 2 decreases expression EXP Nicotine results in decreased expression of GAD2 mRNA CTD PMID:28555334 NCBI chr17:89,671,718...89,734,246
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Gal galanin and GMAP prepropeptide decreases expression ISO Nicotine results in decreased expression of GAL mRNA CTD PMID:21955143 NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:200,650,439...200,654,959
JBrowse link
G Gale UDP-galactose-4-epimerase decreases expression ISO Nicotine results in decreased expression of GALE mRNA CTD PMID:16949557 NCBI chr 5:153,477,420...153,481,926
Ensembl chr 5:148,194,791...148,198,388
JBrowse link
G Galk2 galactokinase 2 increases expression ISO Nicotine results in increased expression of GALK2 mRNA CTD PMID:17456735 NCBI chr 3:133,563,524...133,696,423
Ensembl chr 3:113,110,030...113,233,306
JBrowse link
G Gap43 growth associated protein 43 multiple interactions ISO [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein] CTD PMID:23933227 NCBI chr11:71,882,131...71,975,799
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAPDH mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAPDH mRNA] CTD PMID:20230807 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gata2 GATA binding protein 2 multiple interactions
increases expression
ISO 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 protein]
Nicotine results in increased expression of GATA2 mRNA; Nicotine results in increased expression of GATA2 protein
CTD PMID:18450646 NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions ISO [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA4 protein binds to SP1 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter] CTD PMID:24089524 NCBI chr15:41,635,572...41,707,252
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G Gata6 GATA binding protein 6 multiple interactions ISO [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine promotes the reaction [GATA6 protein binds to SP1 protein]
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GATA6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GATA6 mRNA]
CTD PMID:20230807 PMID:24089524 NCBI chr18:2,460,909...2,492,322
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Gatad2b GATA zinc finger domain containing 2B increases expression ISO Nicotine results in increased expression of GATAD2B mRNA CTD PMID:33640489 NCBI chr 2:178,046,192...178,127,633
Ensembl chr 2:175,749,433...175,825,542
JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression ISO Nicotine results in increased expression of GCH1 mRNA CTD PMID:16949557 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GCLC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GCLC mRNA] CTD PMID:20230807 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gcm1 glial cells missing transcription factor 1 decreases expression EXP Nicotine results in decreased expression of GCM1 mRNA; Nicotine results in decreased expression of GCM1 protein CTD PMID:24368670 NCBI chr 8:87,805,993...87,819,229
Ensembl chr 8:78,925,687...78,938,924
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 increases expression
decreases expression
ISO Nicotine results in increased expression of GCNT2 mRNA
Nicotine results in decreased expression of GCNT2 mRNA
CTD PMID:17997037 PMID:21955143 NCBI chr17:24,002,592...24,107,339
Ensembl chr17:23,796,859...23,901,611
JBrowse link
G Gdf1 growth differentiation factor 1 increases expression ISO Nicotine results in increased expression of GDF1 mRNA CTD PMID:18247414 NCBI chr16:19,131,271...19,146,480
Ensembl chr16:19,097,314...19,112,519
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle increases expression ISO Nicotine results in increased expression of GEM mRNA CTD PMID:17456735 NCBI chr 5:30,011,641...30,022,554
Ensembl chr 5:25,214,309...25,225,222
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression
ISO Nicotine results in decreased expression of GFAP mRNA
Nicotine results in increased expression of GFAP mRNA
CTD PMID:17997037 PMID:21955143 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Ggct gamma-glutamyl cyclotransferase increases splicing ISO Nicotine results in increased splicing of GGCT mRNA alternative form CTD PMID:23825647 NCBI chr 4:85,453,387...85,459,597
Ensembl chr 4:84,123,118...84,129,277
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases activity
multiple interactions
EXP Nicotine results in increased activity of GGT1 protein
Sodium Acetate inhibits the reaction [Nicotine results in increased activity of GGT1 protein]
CTD PMID:31857090 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Ghitm growth hormone inducible transmembrane protein multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GHITM mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GHITM mRNA] CTD PMID:20230807 NCBI chr16:12,907,062...12,918,149
Ensembl chr16:12,885,553...12,897,879
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO Nicotine results in increased expression of GJA1 mRNA; Nicotine results in increased expression of GJA1 protein CTD PMID:36720419 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gja4 gap junction protein, alpha 4 increases expression EXP Nicotine results in increased expression of GJA4 mRNA CTD PMID:28087314 NCBI chr 5:144,917,791...144,920,324
Ensembl chr 5:139,633,287...139,635,925
JBrowse link
G Gjc2 gap junction protein, gamma 2 increases expression ISO Nicotine results in increased expression of GJC2 mRNA CTD PMID:21955143 NCBI chr10:44,462,203...44,470,924
Ensembl chr10:43,962,642...43,970,467
JBrowse link
G Glipr1 GLI pathogenesis-related 1 increases expression ISO Nicotine results in increased expression of GLIPR1 mRNA CTD PMID:16949557 NCBI chr 7:49,373,579...49,399,190
Ensembl chr 7:47,487,345...47,498,429
JBrowse link
G Gm2a ganglioside GM2 activator increases expression
increases splicing
ISO Nicotine results in increased expression of GM2A mRNA
Nicotine results in increased splicing of GM2A mRNA alternative form
CTD PMID:23825647 NCBI chr10:39,719,919...39,732,452
Ensembl chr10:39,219,243...39,231,757
JBrowse link
G Gmfb glia maturation factor, beta multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GMFB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GMFB mRNA] CTD PMID:20230807 NCBI chr15:22,549,705...22,560,125
Ensembl chr15:20,067,263...20,080,331
JBrowse link
G Gnai2 G protein subunit alpha i2 increases splicing
multiple interactions
ISO Nicotine results in increased splicing of GNAI2 mRNA alternative form
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GNAI2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GNAI2 mRNA]
CTD PMID:20230807 PMID:23825647 NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Gng10 G protein subunit gamma 10 increases expression ISO Nicotine results in increased expression of GNG10 mRNA CTD PMID:16949557 NCBI chr 5:78,651,167...78,658,060
Ensembl chr 5:73,856,164...73,863,012
Ensembl chr 5:73,856,164...73,863,012
JBrowse link
G Gng11 G protein subunit gamma 11 decreases expression ISO Nicotine results in decreased expression of GNG11 mRNA CTD PMID:21955143 NCBI chr 4:32,977,681...32,983,121
Ensembl chr 4:32,023,003...32,028,442
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor decreases expression EXP Nicotine results in decreased expression of GNRHR mRNA CTD PMID:28986172 NCBI chr14:22,211,666...22,229,654
Ensembl chr14:21,856,871...21,874,861
JBrowse link
G Golga4 golgin A4 multiple interactions
increases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA] CTD PMID:16949557 NCBI chr 8:127,085,830...127,163,227 JBrowse link
G Golt1b golgi transport 1B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GOLT1B mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GOLT1B mRNA] CTD PMID:20230807 NCBI chr 4:177,064,071...177,077,165
Ensembl chr 4:175,333,092...175,346,153
JBrowse link
G Gosr2 golgi SNAP receptor complex member 2 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of GOSR2 mRNA CTD PMID:28065790 NCBI chr10:89,085,323...89,105,665
Ensembl chr10:88,586,299...88,605,625
JBrowse link
G Gpatch2 G patch domain containing 2 increases splicing ISO Nicotine results in increased splicing of GPATCH2 mRNA alternative form CTD PMID:23825647 NCBI chr13:101,316,413...101,457,109
Ensembl chr13:98,784,969...98,925,661
JBrowse link
G Gpnmb glycoprotein nmb increases expression ISO Nicotine results in increased expression of GPNMB mRNA CTD PMID:23825647 NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:78,010,197...78,049,367
JBrowse link
G Gpr50 G protein-coupled receptor 50 increases expression
increases splicing
ISO Nicotine results in increased expression of GPR50 mRNA
Nicotine results in increased splicing of GPR50 mRNA alternative form
CTD PMID:23825647 NCBI chr  X:154,413,592...154,419,236
Ensembl chr  X:149,368,900...149,373,486
JBrowse link
G Gpr6 G protein-coupled receptor 6 increases expression ISO Nicotine results in increased expression of GPR6 mRNA CTD PMID:21955143 NCBI chr20:46,072,480...46,075,251
Ensembl chr20:44,489,853...44,492,624
JBrowse link
G Gpr83 G protein-coupled receptor 83 increases expression EXP Nicotine results in increased expression of GPR83 mRNA CTD PMID:27782041 NCBI chr 8:19,974,995...19,985,483
Ensembl chr 8:11,693,540...11,704,028
JBrowse link
G Gpr88 G-protein coupled receptor 88 increases expression ISO Nicotine results in increased expression of GPR88 mRNA CTD PMID:21955143 NCBI chr 2:206,876,373...206,885,034
Ensembl chr 2:204,191,427...204,199,733
JBrowse link
G Gprasp1 G protein-coupled receptor associated sorting protein 1 increases expression ISO Nicotine results in increased expression of GPRASP1 mRNA CTD PMID:17456735 NCBI chr  X:103,556,493...103,564,275
Ensembl chr  X:98,709,841...98,772,851
JBrowse link
G Gprc5b G protein-coupled receptor, class C, group 5, member B increases expression ISO Nicotine results in increased expression of GPRC5B mRNA CTD PMID:21955143 NCBI chr 1:182,748,247...182,772,711
Ensembl chr 1:173,316,907...173,340,932
JBrowse link
G Gprc5c G protein-coupled receptor, class C, group 5, member C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPRC5C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPRC5C mRNA] CTD PMID:20230807 NCBI chr10:100,385,682...100,407,953
Ensembl chr10:99,887,077...99,908,926
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression
ISO
EXP
Nicotine inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]
Nicotine results in increased expression of GPT protein
dexpanthenol inhibits the reaction [Nicotine results in increased expression of GPT protein]
CTD PMID:35411647 PMID:38229321 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
increases expression
ISO
EXP
Nicotine results in decreased expression of GPX1 mRNA
Nicotine results in increased expression of GPX1 protein
CTD PMID:16949557 PMID:18343235 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA] CTD PMID:20230807 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Gramd1b GRAM domain containing 1B increases expression ISO Nicotine results in increased expression of GRAMD1B mRNA CTD PMID:23825647 NCBI chr 8:49,551,642...49,790,965
Ensembl chr 8:40,659,182...40,893,925
JBrowse link
G Grid1 glutamate ionotropic receptor delta type subunit 1 decreases methylation EXP Nicotine results in decreased methylation of GRID1 gene CTD PMID:32994467 NCBI chr16:10,145,018...10,894,184
Ensembl chr16:10,138,925...10,885,808
JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GRID2 mRNA; [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GRID2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRID2 mRNA] CTD PMID:20230807 NCBI chr 4:93,745,165...95,222,354
Ensembl chr 4:92,415,230...93,889,355
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 increases expression ISO Nicotine results in increased expression of GRIK2 mRNA CTD PMID:17997037 NCBI chr20:53,717,564...54,415,283
Ensembl chr20:52,133,851...52,838,375
JBrowse link
G Grm1 glutamate metabotropic receptor 1 decreases expression EXP Nicotine results in decreased expression of GRM1 mRNA CTD PMID:28339662 NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Grm2 glutamate metabotropic receptor 2 affects expression EXP Nicotine affects the expression of GRM2 mRNA CTD PMID:28339662 NCBI chr 8:116,158,810...116,171,857
Ensembl chr 8:107,280,099...107,293,146
JBrowse link
G Grm5 glutamate metabotropic receptor 5 increases expression ISO Nicotine results in increased expression of GRM5 mRNA CTD PMID:21955143 NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:141,312,368...141,882,274
JBrowse link
G Gsdma gasdermin A increases expression ISO Nicotine results in increased expression of GSDMA mRNA CTD PMID:23825647 NCBI chr10:84,110,590...84,135,804
Ensembl chr10:83,627,051...83,639,543
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions
increases expression
ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein
Nicotine results in increased expression of GSK3A mRNA
Nicotine results in increased expression of and results in decreased phosphorylation of GSK3A protein
CTD PMID:12511591 PMID:31945395 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases expression
increases expression
ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein
Nicotine results in decreased expression of GSK3B mRNA; Nicotine results in decreased expression of GSK3B protein
Nicotine results in increased expression of GSK3B mRNA
Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of GSK3B mRNA]; Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of GSK3B protein]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSK3B mRNA]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSK3B protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in decreased expression of GSK3B mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in decreased expression of GSK3B protein]; Nicotine results in increased expression of and results in decreased phosphorylation of GSK3B protein
CTD PMID:12511591 PMID:31945395 PMID:33640489 PMID:35411647 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP
ISO
Nicotine results in decreased activity of GSR protein CTD PMID:19778253 PMID:20498001 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression
increases expression
increases activity
EXP Nicotine results in decreased expression of GSTA4 mRNA
Nicotine results in increased expression of GSTA4 mRNA
Nicotine results in increased activity of GSTA4 protein
CTD PMID:9774145 NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Nicotine results in decreased expression of GSTK1 mRNA CTD PMID:17997037 NCBI chr 4:72,085,532...72,089,934
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression ISO Nicotine results in decreased expression of GSTM2 mRNA CTD PMID:33640489 NCBI chr 2:198,312,179...198,316,962
Ensembl chr 2:195,544,426...195,628,961
JBrowse link
G Guca1a guanylate cyclase activator 1A decreases expression ISO Nicotine results in decreased expression of GUCA1A mRNA CTD PMID:16949557 NCBI chr 9:21,080,782...21,096,221
Ensembl chr 9:13,588,525...13,598,565
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] CTD PMID:23907605 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239
JBrowse link
G H2az2 H2A.Z variant histone 2 decreases expression ISO Nicotine results in decreased expression of H2AZ2 mRNA CTD PMID:17456735 NCBI chr14:85,507,228...85,526,166
Ensembl chr14:81,293,299...81,312,144
Ensembl chr 4:81,293,299...81,312,144
Ensembl chr16:81,293,299...81,312,144
JBrowse link
G H3c1 H3 clustered histone 1 increases expression ISO Nicotine results in increased expression of H3C1 protein CTD PMID:35929799 NCBI chr17:41,796,236...41,796,759
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
JBrowse link
G Hand1 heart and neural crest derivatives expressed 1 decreases expression EXP
ISO
Nicotine results in decreased expression of HAND1 mRNA; Nicotine results in decreased expression of HAND1 protein CTD PMID:24368670 PMID:31507073 NCBI chr10:42,507,117...42,509,684
Ensembl chr10:42,006,651...42,009,213
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO Nicotine results in increased expression of HAVCR1 protein CTD PMID:21511693 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HBA-A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HBA-A1 mRNA] CTD PMID:20230807 NCBI chr10:15,841,724...15,842,580
Ensembl chr10:15,307,815...15,338,392
JBrowse link
G Hdac1 histone deacetylase 1 increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of HDAC1 mRNA
Nicotine results in increased expression of HDAC1 mRNA; Nicotine results in increased expression of HDAC1 protein
SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 protein]
CTD PMID:24709674 PMID:34245815 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hdac2 histone deacetylase 2 increases expression
multiple interactions
decreases expression
EXP
ISO
Nicotine results in increased expression of HDAC2 mRNA; Nicotine results in increased expression of HDAC2 protein
SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 protein]
Nicotine results in decreased expression of HDAC2 protein
CTD PMID:24709674 PMID:31507073 PMID:31846720 PMID:34245815 NCBI chr20:42,101,815...42,126,486
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hdac4 histone deacetylase 4 increases expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of HDAC4 mRNA; Nicotine results in increased expression of HDAC4 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein]
CTD PMID:31846720 NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:92,507,611...92,750,164
JBrowse link
G Hdac7 histone deacetylase 7 increases expression ISO Nicotine results in increased expression of HDAC7 mRNA CTD PMID:24709674 NCBI chr 7:130,803,013...130,841,181
Ensembl chr 7:128,923,920...128,962,072
JBrowse link
G Hddc2 HD domain containing 2 increases expression ISO Nicotine results in increased expression of HDDC2 mRNA CTD PMID:23825647 NCBI chr 1:28,100,669...28,133,008
Ensembl chr 1:26,294,030...26,313,935
JBrowse link
G Hells helicase, lymphoid specific multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA] CTD PMID:20230807 NCBI chr 1:246,113,580...246,159,230
Ensembl chr 1:236,701,758...236,746,844
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 increases expression ISO Nicotine results in increased expression of HEY1 mRNA CTD PMID:23825647 NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:93,095,498...93,100,312
JBrowse link
G Hgf hepatocyte growth factor affects expression
decreases expression
multiple interactions
EXP
ISO
Nicotine affects the expression of HGF mRNA
Nicotine results in decreased expression of HGF protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA
CTD PMID:32512034 PMID:33091441 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
decreases expression
multiple interactions
ISO Nicotine results in increased expression of HIF1A protein
Nicotine results in decreased expression of HIF1A mRNA
resveratrol inhibits the reaction [Nicotine results in decreased expression of HIF1A mRNA]
CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of HIF1A protein]
CTD PMID:22687363 PMID:24793809 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA; Mecamylamine inhibits the reaction [Nicotine results in increased expression of HINT1 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA]
Nicotine results in increased expression of HINT1 mRNA
CTD PMID:20230807 PMID:20514075 NCBI chr10:39,490,225...39,493,970
Ensembl chr 4:92,100,973...92,101,568
JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HIPK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HIPK1 mRNA] CTD PMID:20230807 NCBI chr 2:193,937,261...193,988,247
Ensembl chr 2:191,248,817...191,298,902
JBrowse link
G Hist1h2bc histone cluster 1, H2bc decreases expression ISO Nicotine results in decreased expression of H2BC4 mRNA CTD PMID:17456735 NCBI chr17:47,388,085...47,392,349
Ensembl chr17:42,694,723...42,696,642
JBrowse link
G Hist1h2bd histone cluster 1 H2B family member D increases expression ISO Nicotine results in increased expression of H2BC5 protein CTD PMID:35929799 NCBI chr17:47,488,627...47,489,008 JBrowse link
G Hltf helicase-like transcription factor decreases expression ISO Nicotine results in decreased expression of HLTF mRNA CTD PMID:18247414 NCBI chr 2:104,478,725...104,538,531
Ensembl chr 2:102,549,724...102,609,327
JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO Nicotine results in decreased expression of HMGA1 mRNA CTD PMID:16949557 NCBI chr20:5,612,902...5,620,596
Ensembl chr20:5,611,694...5,618,752
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression
affects expression
ISO
EXP
Nicotine results in increased expression of HMGCR mRNA
Nicotine affects the expression of HMGCR mRNA
CTD PMID:23416264 PMID:31972234 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Nicotine results in increased expression of HMGCS1 mRNA CTD PMID:21955143 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmox1 heme oxygenase 1 increases response to substance
affects expression
increases expression
multiple interactions
ISO
EXP
HMOX1 protein results in increased susceptibility to Nicotine
Nicotine affects the expression of HMOX1 mRNA
Nicotine results in increased expression of HMOX1 mRNA; Nicotine results in increased expression of HMOX1 protein
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 protein; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]; HMOX1 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HMOX1 protein]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA]
CTD PMID:22954530 PMID:23933227 PMID:23942037 PMID:24095726 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 increases expression ISO Nicotine results in increased expression of HNRNPA3 mRNA CTD PMID:17456735 NCBI chr 3:80,984,470...80,999,413
Ensembl chr 3:60,578,673...60,588,306
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HNRNPC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HNRNPC mRNA] CTD PMID:20230807 NCBI chr15:27,253,098...27,282,779
Ensembl chr15:24,779,450...24,809,183
JBrowse link
G Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 increases expression ISO Nicotine results in increased expression of HNRNPH2 mRNA CTD PMID:17456735 NCBI chr  X:102,074,175...102,080,115
Ensembl chr  X:97,780,785...97,787,041
JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L decreases expression ISO Nicotine results in decreased expression of HNRNPL mRNA CTD PMID:21955143 NCBI chr 1:93,226,373...93,239,084
Ensembl chr 1:84,100,879...84,111,553
JBrowse link
G Hnrnpll heterogeneous nuclear ribonucleoprotein L-like increases expression ISO Nicotine results in increased expression of HNRNPLL mRNA CTD PMID:17997037 NCBI chr 6:20,720,013...20,752,803
Ensembl chr 6:14,970,057...14,999,745
JBrowse link
G Hnrnpr heterogeneous nuclear ribonucleoprotein R increases expression ISO Nicotine results in increased expression of HNRNPR mRNA CTD PMID:17997037 NCBI chr 5:153,826,482...153,872,272
Ensembl chr 5:148,543,044...148,574,867
JBrowse link
G Homer1 homer scaffold protein 1 decreases expression ISO Nicotine results in decreased expression of HOMER1 mRNA CTD PMID:21955143 NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Hoxb9 homeo box B9 increases expression ISO Nicotine results in increased expression of HOXB9 mRNA CTD PMID:23825647 NCBI chr10:81,733,857...81,737,363
Ensembl chr10:81,237,312...81,240,818
JBrowse link
G Hp1bp3 heterochromatin protein 1, binding protein 3 increases expression ISO Nicotine results in increased expression of HP1BP3 mRNA CTD PMID:16949557 NCBI chr 5:155,719,109...155,746,329
Ensembl chr 5:150,433,740...150,463,000
JBrowse link
G Hpca hippocalcin increases expression ISO Nicotine results in increased expression of HPCA mRNA CTD PMID:21955143 NCBI chr 5:146,739,978...146,750,961
Ensembl chr 5:141,455,613...141,463,841
JBrowse link
G Hpcal4 hippocalcin-like 4 increases expression ISO Nicotine results in increased expression of HPCAL4 mRNA CTD PMID:23825647 NCBI chr 5:140,739,577...140,751,529
Ensembl chr 5:135,454,540...135,466,416
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases activity
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA]
Nicotine results in increased activity of HRAS protein
CTD PMID:15983034 PMID:20230807 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases expression
affects expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of HSD11B1 mRNA
Nicotine affects the expression of HSD11B1 mRNA
ursodoxicoltaurine inhibits the reaction [Nicotine results in increased expression of HSD11B1 mRNA]
CTD PMID:21955143 PMID:22265867 PMID:26803847 PMID:31972234 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression
affects expression
increases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of HSD11B2 mRNA; Nicotine results in decreased expression of HSD11B2 protein
Nicotine affects the expression of HSD11B2 mRNA
Nicotine results in increased expression of HSD11B2 mRNA; Nicotine results in increased expression of HSD11B2 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]
CTD PMID:22265867 PMID:29486207 PMID:31972234 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions
decreases expression
EXP
ISO
Taurine inhibits the reaction [Nicotine results in decreased expression of HSD17B1 protein]
Nicotine results in decreased expression of HSD17B1 mRNA
Nicotine results in decreased expression of HSD17B1 mRNA; Nicotine results in decreased expression of HSD17B1 protein
CTD PMID:20498001 PMID:30959089 NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,009,728...86,011,927
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases activity
decreases expression
EXP Nicotine results in decreased activity of HSD17B3 protein
Nicotine results in decreased expression of HSD17B3 mRNA; Nicotine results in decreased expression of HSD17B3 protein
CTD PMID:28986172 NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,027,229...1,058,554
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases splicing ISO Nicotine results in increased splicing of HSD17B7 mRNA alternative form CTD PMID:23825647 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:82,173,179...82,190,017
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression
decreases activity
EXP
ISO
Nicotine results in decreased expression of HSD3B1 mRNA; Nicotine results in decreased expression of HSD3B1 protein
Nicotine results in decreased activity of HSD3B1 protein
CTD PMID:28986172 PMID:30959089 NCBI chr 2:188,858,574...188,864,694
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA]
Nicotine results in increased expression of HSP90AA1 mRNA; Nicotine results in increased expression of HSP90AA1 protein
CTD PMID:12115584 PMID:20230807 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of HSPA5
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPA5 protein]
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]; Nicotine inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]
CTD PMID:18477628 PMID:24201001 PMID:28082123 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPE1 mRNA] CTD PMID:20230807 NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:56,589,789...56,593,089
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression
increases expression
ISO
EXP
Nicotine results in decreased expression of HTR1A protein
Nicotine results in increased expression of HTR1A protein
CTD PMID:21324836 PMID:30247698 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions EXP Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein] CTD PMID:21316381 NCBI chr 8:91,395,405...91,414,815
Ensembl chr 8:82,517,360...82,534,549
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
increases expression
EXP [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of HTR2A protein; Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein]
Nicotine results in increased expression of HTR2A protein
CTD PMID:21316381 PMID:30247698 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Ibsp integrin-binding sialoprotein decreases expression EXP Nicotine results in decreased expression of IBSP mRNA CTD PMID:29981921 NCBI chr14:5,744,497...5,757,242
Ensembl chr14:5,439,829...5,452,693
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Nicotine results in increased expression of ICAM1 protein CTD PMID:12575837 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression ISO Nicotine results in decreased expression of ID1 mRNA CTD PMID:17997037 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Id2 inhibitor of DNA binding 2 increases splicing ISO Nicotine results in increased splicing of ID2 mRNA alternative form CTD PMID:23825647 NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression ISO Nicotine results in decreased expression of ID3 mRNA CTD PMID:17456735 NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression
increases expression
ISO Nicotine results in decreased expression of IDI1 mRNA
Nicotine results in increased expression of IDI1 mRNA
CTD PMID:16949557 PMID:17997037 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 increases expression
multiple interactions
ISO Nicotine results in increased expression of IFI27 mRNA
Nicotine inhibits the reaction [nickel chloride results in increased expression of IFI27 mRNA]
CTD PMID:23825647 PMID:37951547 NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:122,590,472...122,779,294
JBrowse link
G Ifi44 interferon-induced protein 44 increases expression ISO Nicotine results in increased expression of IFI44 mRNA CTD PMID:23825647 NCBI chr 2:243,286,050...243,303,869
Ensembl chr 2:240,626,066...240,643,844
JBrowse link
G Ifi44l interferon-induced protein 44-like increases expression ISO Nicotine results in increased expression of IFI44L mRNA CTD PMID:23825647 NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:240,668,713...240,706,359
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA] CTD PMID:31154625 NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:47,227,364...47,275,456
JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of IFITM1 mRNA CTD PMID:37951547 NCBI chr 1:205,496,757...205,498,796
Ensembl chr 1:196,067,963...196,069,169
JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 decreases expression ISO Nicotine results in decreased expression of IFNAR1 mRNA CTD PMID:18247414 NCBI chr11:44,211,769...44,238,206
Ensembl chr11:30,725,790...30,749,979
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein] CTD PMID:31154625 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma multiple interactions ISO Nicotine inhibits the reaction [IFNG protein results in increased expression of TNF mRNA] CTD PMID:24095726 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression
affects expression
increases expression
multiple interactions
EXP Nicotine results in decreased expression of IGF1 mRNA; Nicotine results in decreased expression of IGF1 protein
Nicotine affects the expression of IGF1 mRNA; Nicotine affects the expression of IGF1 protein
Nicotine results in increased expression of IGF1 mRNA
rosiglitazone inhibits the reaction [Nicotine results in decreased expression of IGF1 protein]
CTD PMID:20960268 PMID:22265867 PMID:29486207 PMID:31972234 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression
affects expression
increases expression
EXP Nicotine results in decreased expression of IGF1R mRNA; Nicotine results in decreased expression of IGF1R protein
Nicotine affects the expression of IGF1R mRNA
Nicotine results in increased expression of IGF1R mRNA
CTD PMID:20426880 PMID:20960268 PMID:22265867 PMID:31972234 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igf2 insulin-like growth factor 2 increases expression EXP Nicotine results in increased expression of IGF2 mRNA CTD PMID:29486207 NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Igf2bp2 insulin-like growth factor 2 mRNA binding protein 2 increases expression ISO Nicotine results in increased expression of IGF2BP2 mRNA CTD PMID:17997037 NCBI chr11:92,378,908...92,478,893
Ensembl chr11:78,874,414...78,974,377
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression ISO Nicotine results in increased expression of IGFBP2 mRNA CTD PMID:23825647 NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Igsf1 immunoglobulin superfamily, member 1 decreases expression ISO Nicotine results in decreased expression of IGSF1 mRNA CTD PMID:21955143 NCBI chr  X:133,947,717...133,963,154
Ensembl chr  X:129,069,896...129,085,139
JBrowse link
G Igsf3 immunoglobulin superfamily, member 3 increases expression ISO Nicotine results in increased expression of IGSF3 mRNA CTD PMID:23825647 NCBI chr 2:191,499,972...191,588,249
Ensembl chr 2:188,811,380...188,899,645
JBrowse link
G Ihh Indian hedgehog signaling molecule increases expression EXP Nicotine results in increased expression of IHH mRNA CTD PMID:27782041 NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:76,504,315...76,510,532
JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions
decreases secretion
ISO Nicotine results in decreased expression of IL10 mRNA
Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Nicotine results in decreased secretion of IL10 protein
[Eugenol co-treated with Acetylcysteine] inhibits the reaction [Nicotine results in decreased secretion of IL10 protein]; Acetylcysteine inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]; Eugenol inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]; Nicotine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]
CTD PMID:18247414 PMID:21237301 PMID:29673796 PMID:31926917 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein] CTD PMID:21237301 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Eugenol inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein] CTD PMID:21237301 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA] CTD PMID:23199342 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 increases secretion
increases expression
multiple interactions
ISO
EXP
Nicotine results in increased secretion of IL18 protein
Nicotine results in increased expression of IL18 protein
Nicotine results in increased expression of IL18 mRNA
CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL18 protein]
CTD PMID:35131329 PMID:39098741 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Nicotine results in increased expression of and results in increased secretion of IL1A protein CTD PMID:18082304 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion
decreases expression
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA; CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL1B protein]; Nicotine inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]; Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Nicotine results in increased expression of and results in increased secretion of IL1B protein; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of IL1B protein]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]; U 0126 inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]
Nicotine results in increased expression of IL1B mRNA
Nicotine results in decreased expression of IL1B protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of IL1B mRNA; Nicotine inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
Nicotine results in increased expression of IL1B mRNA; Nicotine results in increased expression of IL1B protein
Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD PMID:15976189 PMID:16254210 PMID:18082304 PMID:19673871 PMID:20943775 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions
increases expression
EXP methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 mRNA]; methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 protein]
Nicotine results in increased expression of IL1R1 mRNA; Nicotine results in increased expression of IL1R1 protein
CTD PMID:27180639 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:42,504,735...42,579,937
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions EXP IL1RN protein inhibits the reaction [Nicotine results in increased activity of Capsaicin] CTD PMID:27180639 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Nicotine results in decreased susceptibility to IL2 protein CTD PMID:15231866 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il33 interleukin 33 increases secretion
multiple interactions
ISO Nicotine results in increased secretion of IL33 protein
[Nicotine co-treated with Quartz] results in increased expression of IL33 protein
Nicotine promotes the reaction [Lipopolysaccharides results in increased secretion of IL33 protein]
CTD PMID:29673796 PMID:36868510 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Il3ra interleukin 3 receptor subunit alpha decreases expression ISO Nicotine results in decreased expression of IL3RA mRNA CTD PMID:18247414 NCBI chr12:21,431,848...21,437,336
Ensembl chr12:16,318,081...16,323,484
JBrowse link
G Il4r interleukin 4 receptor multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of IL4RA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL4RA mRNA] CTD PMID:20230807 NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
decreases secretion
decreases expression
increases expression
ISO
EXP
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA; [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased secretion of IL6 protein; [Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased secretion of IL6 protein; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Nicotine results in increased expression of and results in increased secretion of IL6 protein; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA]
Nicotine results in increased secretion of IL6 protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of IL6 mRNA
Nicotine results in decreased secretion of IL6 protein
Nicotine results in decreased expression of IL6 mRNA; Nicotine results in decreased expression of IL6 protein
Nicotine results in increased expression of IL6 mRNA; Nicotine results in increased expression of IL6 protein
Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of IL6 mRNA]
CTD PMID:18082304 PMID:19673871 PMID:20943775 PMID:22093924 PMID:23199342 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il7 interleukin 7 multiple interactions ISO Nicotine results in increased expression of and results in increased secretion of IL7 protein CTD PMID:18082304 NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Il9 interleukin 9 decreases expression ISO Nicotine results in decreased expression of IL9 mRNA CTD PMID:18247414 NCBI chr17:8,117,028...8,120,151
Ensembl chr17:8,111,772...8,114,895
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 decreases expression ISO Nicotine results in decreased expression of INPPL1 mRNA CTD PMID:17456735 NCBI chr 1:165,595,047...165,609,503
Ensembl chr 1:156,183,059...156,197,500
JBrowse link
G Ins1 insulin 1 multiple interactions
increases expression
ISO
EXP
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PRDM16 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA
Sodium Acetate inhibits the reaction [Nicotine results in increased expression of INS1 protein]
CTD PMID:29155039 PMID:31857090 PMID:33091441 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Ins2 insulin 2 increases expression EXP Nicotine results in increased expression of INS2 mRNA CTD PMID:20426880 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Insig1 insulin induced gene 1 increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of INSIG1 mRNA
Nicotine results in decreased expression of INSIG1 mRNA
CTD PMID:23416264 PMID:26776438 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Insr insulin receptor decreases expression EXP Nicotine results in decreased expression of INSR mRNA; Nicotine results in decreased expression of INSR protein CTD PMID:20960268 PMID:22265867 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA] CTD PMID:20230807 NCBI chr  X:156,919,927...156,929,825
Ensembl chr  X:151,768,777...151,778,521
JBrowse link
G Irf6 interferon regulatory factor 6 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of IRF6 mRNA CTD PMID:37951547 NCBI chr13:107,200,876...107,220,083
Ensembl chr13:104,672,179...104,691,386
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions ISO IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IRF7 mRNA] CTD PMID:31154625 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Irf8 interferon regulatory factor 8 decreases expression
multiple interactions
ISO Nicotine results in decreased expression of IRF8 mRNA
[nickel chloride co-treated with Nicotine] results in increased expression of IRF8 mRNA
CTD PMID:17456735 PMID:37951547 NCBI chr19:65,699,284...65,721,066
Ensembl chr19:48,790,588...48,811,829
JBrowse link
G Irf9 interferon regulatory factor 9 increases expression ISO Nicotine results in increased expression of IRF9 mRNA CTD PMID:33640489 NCBI chr15:33,065,422...33,071,881
Ensembl chr15:29,095,789...29,101,236
JBrowse link
G Irs1 insulin receptor substrate 1 decreases expression EXP Nicotine results in decreased expression of IRS1 mRNA CTD PMID:22265867 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Irx3 iroquois homeobox 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA] CTD PMID:20230807 NCBI chr19:31,384,803...31,388,241
Ensembl chr19:15,211,878...15,215,317
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA] CTD PMID:31154625 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of ISG20 mRNA CTD PMID:37951547 NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Itga2b integrin subunit alpha 2b decreases expression ISO Nicotine results in decreased expression of ITGA2B mRNA; Nicotine results in decreased expression of ITGA2B protein CTD PMID:21385097 NCBI chr10:87,908,697...87,926,225
Ensembl chr10:87,408,536...87,426,168
JBrowse link
G Itgal integrin subunit alpha L decreases expression ISO Nicotine results in decreased expression of ITGAL mRNA CTD PMID:18247414 NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:181,918,183...181,955,732
JBrowse link
G Itgav integrin subunit alpha V increases expression ISO Nicotine results in increased expression of ITGAV mRNA CTD PMID:17997037 NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Nicotine results in decreased expression of ITGB1 protein CTD PMID:11338295 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Itgb3 integrin subunit beta 3 decreases expression ISO Nicotine results in decreased expression of ITGB3 mRNA; Nicotine results in decreased expression of ITGB3 protein CTD PMID:21385097 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Itgb5 integrin subunit beta 5 increases expression EXP Nicotine results in increased expression of ITGB5 mRNA CTD PMID:20426880 NCBI chr11:80,333,588...80,449,373
Ensembl chr11:66,829,285...66,944,472
JBrowse link
G Itm2b integral membrane protein 2B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ITM2B mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ITM2B mRNA] CTD PMID:20230807 NCBI chr15:54,955,549...54,978,455
Ensembl chr15:48,546,001...48,568,917
JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B increases expression EXP Nicotine results in increased expression of ITPKB mRNA CTD PMID:11478936 NCBI chr13:94,601,072...94,696,180
Ensembl chr13:92,069,216...92,162,004
JBrowse link
G Ivl involucrin decreases expression ISO Nicotine results in decreased expression of IVL protein CTD PMID:16011614 NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:178,147,061...178,149,100
JBrowse link
G Jagn1 jagunal homolog 1 decreases expression ISO Nicotine results in decreased expression of JAGN1 mRNA CTD PMID:17997037 NCBI chr 4:148,147,213...148,151,915
Ensembl chr 4:146,591,510...146,596,288
JBrowse link
G Jak2 Janus kinase 2 increases response to substance
increases phosphorylation
multiple interactions
decreases expression
ISO
EXP
JAK2 results in increased susceptibility to Nicotine
Nicotine results in increased phosphorylation of JAK2 protein
Bungarotoxins inhibits the reaction [Nicotine results in increased phosphorylation of JAK2 protein]
Nicotine results in decreased expression of JAK2 mRNA
CTD PMID:20943775 PMID:29155039 PMID:34153408 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of JMJD6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of JMJD6 mRNA] CTD PMID:20230807 NCBI chr10:102,539,935...102,545,986
Ensembl chr10:102,041,120...102,047,182
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation
multiple interactions
ISO
EXP
Nicotine results in increased expression of JUN protein
Nicotine results in increased phosphorylation of JUN protein
Nicotine promotes the reaction [MAPK8 protein results in increased phosphorylation of JUN protein]
[U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; Nicotine inhibits the reaction [Cisplatin results in increased expression of JUN mRNA]
CTD PMID:11592233 PMID:17003101 PMID:17021677 PMID:21511693 PMID:34890707 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression
ISO Nicotine results in increased expression of JUNB mRNA
Nicotine results in decreased expression of JUNB mRNA
CTD PMID:17456735 PMID:17997037 PMID:18805435 PMID:21955143 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Kat6b lysine acetyltransferase 6B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of KAT6B mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KAT6B mRNA] CTD PMID:20230807 NCBI chr15:2,688,535...2,861,443
Ensembl chr15:2,639,200...2,812,316
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 increases expression ISO Nicotine results in increased expression of KCNH2 mRNA CTD PMID:17997037 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 decreases expression EXP Nicotine results in decreased expression of KCNK1 mRNA CTD PMID:11478936 NCBI chr19:70,856,985...70,895,053
Ensembl chr19:53,959,657...53,997,724
JBrowse link
G Kdm7a lysine demethylase 7A increases expression ISO Nicotine results in increased expression of KDM7A mRNA CTD PMID:16949557 NCBI chr 4:68,866,263...68,992,979
Ensembl chr 4:67,904,307...67,966,998
JBrowse link
G Kdr kinase insert domain receptor increases expression
decreases expression
EXP Nicotine results in increased expression of KDR mRNA
Nicotine results in decreased expression of KDR protein
CTD PMID:32512034 PMID:33091441 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Kif21b kinesin family member 21B increases expression ISO Nicotine results in increased expression of KIF21B mRNA CTD PMID:23825647 NCBI chr13:50,127,842...50,177,822
Ensembl chr13:47,576,160...47,626,127
JBrowse link
G Kif3b kinesin family member 3B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of KIF3B mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KIF3B mRNA] CTD PMID:20230807 NCBI chr 3:162,218,621...162,258,191
Ensembl chr 3:141,758,466...141,797,963
JBrowse link
G Klf10 KLF transcription factor 10 decreases expression
increases expression
ISO Nicotine results in decreased expression of KLF10 mRNA
Nicotine results in increased expression of KLF10 mRNA
CTD PMID:17456735 PMID:17997037 NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:69,465,619...69,473,994
JBrowse link
G Klf11 KLF transcription factor 11 decreases expression ISO Nicotine results in decreased expression of KLF11 mRNA CTD PMID:18247414 NCBI chr 6:47,014,312...47,026,152
Ensembl chr 6:41,285,842...41,297,550
JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA]
Nicotine results in increased expression of KLF4 mRNA
CTD PMID:17456735 PMID:20230807 NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Klk5 kallikrein related-peptidase 5 increases expression ISO Nicotine results in increased expression of KLK5 mRNA CTD PMID:23825647 NCBI chr 1:103,432,743...103,442,011
Ensembl chr 1:94,296,168...94,304,666
JBrowse link
G Kmt2c lysine methyltransferase 2C multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA] CTD PMID:12588870 NCBI chr 4:10,353,698...10,755,965
Ensembl chr 4:9,609,627...9,833,539
JBrowse link
G Kng1 kininogen 1 decreases activity
multiple interactions
EXP Nicotine results in decreased activity of KNG1 protein alternative form
Capsaicin promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form]; Kainic Acid promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form]
CTD PMID:7807204 NCBI chr11:91,317,354...91,340,148
Ensembl chr11:77,812,752...77,835,555
JBrowse link
G Krt15 keratin 15 increases expression ISO Nicotine results in increased expression of KRT15 mRNA CTD PMID:23825647 NCBI chr10:85,567,197...85,571,014
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Krt80 keratin 80 increases expression ISO Nicotine results in increased expression of KRT80 mRNA CTD PMID:23825647 NCBI chr 7:134,341,951...134,363,872
Ensembl chr 7:132,463,218...132,485,508
JBrowse link
G Krt85 keratin 85 increases expression ISO Nicotine results in increased expression of KRT85 mRNA CTD PMID:23825647 NCBI chr 7:134,508,913...134,515,786
Ensembl chr 7:132,630,058...132,637,049
JBrowse link
G Lamb1 laminin subunit beta 1 increases expression ISO Nicotine results in increased expression of LAMB1 mRNA CTD PMID:16949557 NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:47,835,525...47,902,585
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 decreases expression ISO Nicotine results in decreased expression of LAMP2 protein CTD PMID:33010382 NCBI chr  X:122,038,734...122,087,745
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Lce1b late cornified envelope 1B increases expression ISO Nicotine results in increased expression of LCE1B mRNA CTD PMID:23825647 NCBI chr 2:180,951,824...180,953,140
Ensembl chr 2:178,256,213...178,257,985
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO LCK protein promotes the reaction [Nicotine results in increased phosphorylation of and results in increased activity of FYN protein]; Nicotine results in increased phosphorylation of and results in increased activity of LCK protein CTD PMID:17709503 NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 affects response to substance ISO LCP1 gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr15:56,846,375...56,954,090
Ensembl chr15:50,488,149...50,544,680
JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Nicotine results in increased expression of LDLR mRNA CTD PMID:23416264 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Ldlrad3 low density lipoprotein receptor class A domain containing 3 increases splicing ISO Nicotine results in increased splicing of LDLRAD3 mRNA alternative form CTD PMID:23825647 NCBI chr 3:108,694,528...108,936,330
Ensembl chr 3:88,239,622...88,481,267
JBrowse link
G Lep leptin increases expression
decreases response to substance
EXP Nicotine results in increased expression of LEP protein
Nicotine results in decreased susceptibility to LEP protein
CTD PMID:23623838 PMID:29155039 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lepr leptin receptor increases expression
decreases expression
EXP Nicotine results in increased expression of LEPR mRNA
Nicotine results in decreased expression of LEPR mRNA
CTD PMID:22265867 PMID:29155039 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Lgals1 galectin 1 increases expression ISO Nicotine results in increased expression of LGALS1 mRNA CTD PMID:23825647 NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:110,481,392...110,488,345
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
increases secretion
EXP
ISO
Nicotine results in decreased expression of LHB mRNA; Nicotine results in decreased expression of LHB protein
Nicotine results in increased secretion of LHB protein
CTD PMID:12893845 PMID:20498001 PMID:28986172 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lig4 DNA ligase 4 increases expression ISO Nicotine results in increased expression of LIG4 mRNA CTD PMID:16949557 NCBI chr16:86,220,345...86,228,930
Ensembl chr16:79,518,312...79,527,040
JBrowse link
G Lin7c lin-7 homolog C, crumbs cell polarity complex component decreases expression ISO Nicotine results in decreased expression of LIN7C mRNA CTD PMID:21955143 NCBI chr 3:116,859,425...116,872,363
Ensembl chr 3:96,406,813...96,417,728
JBrowse link
G Lipe lipase E, hormone sensitive type decreases expression EXP Nicotine results in decreased expression of LIPE mRNA CTD PMID:29155039 NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:80,965,627...80,984,310
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor multiple interactions
increases expression
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA]; Mecamylamine promotes the reaction [Nicotine results in decreased expression of LITAF mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA]
Nicotine results in increased expression of LITAF mRNA
CTD PMID:12588870 PMID:21955143 NCBI chr10:5,163,258...5,199,930
Ensembl chr10:4,625,552...4,692,763
JBrowse link
G Lmo7 LIM domain 7 decreases expression ISO Nicotine results in decreased expression of LMO7 mRNA CTD PMID:21955143 NCBI chr15:84,981,689...85,184,554
Ensembl chr15:78,567,023...78,769,783
JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of LPAR4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of LPAR4 mRNA] CTD PMID:20230807 NCBI chr  X:76,106,319...76,119,807
Ensembl chr  X:72,033,486...72,046,977
JBrowse link
G Lpl lipoprotein lipase increases expression ISO Nicotine results in increased expression of LPL mRNA CTD PMID:21955143 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrrfip1 LRR binding FLII interacting protein 1 increases expression ISO Nicotine results in increased expression of LRRFIP1 mRNA CTD PMID:16949557 NCBI chr 9:99,039,590...99,167,805
Ensembl chr 9:91,643,197...91,720,250
JBrowse link
G Lrrtm4 leucine rich repeat transmembrane neuronal 4 increases methylation EXP Nicotine results in increased methylation of LRRTM4 gene CTD PMID:32994467 NCBI chr 4:114,103,783...114,894,696
Ensembl chr 4:112,545,917...113,335,865
JBrowse link
G Ltb lymphotoxin beta decreases expression ISO Nicotine results in decreased expression of LTB mRNA CTD PMID:18247414 NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,627,537...3,629,381
JBrowse link
G Ltf lactotransferrin decreases expression ISO Nicotine results in decreased expression of LTF mRNA CTD PMID:23825647 NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:110,999,948...111,022,795
JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of LTN1 mRNA CTD PMID:28065790 NCBI chr11:40,090,169...40,147,159
Ensembl chr11:26,603,903...26,660,886
JBrowse link
G Lyl1 LYL1, basic helix-loop-helix family member decreases expression ISO Nicotine results in decreased expression of LYL1 mRNA CTD PMID:17456735 NCBI chr19:40,356,967...40,359,834
Ensembl chr19:23,452,140...23,455,007
JBrowse link
G Lysmd3 LysM domain containing 3 affects response to substance ISO LYSMD3 gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr 2:13,669,465...13,675,622
Ensembl chr 2:11,933,768...11,942,961
JBrowse link
G Madd MAP-kinase activating death domain decreases expression ISO Nicotine results in decreased expression of MADD mRNA CTD PMID:18247414 NCBI chr 3:97,570,141...97,613,688
Ensembl chr 3:77,114,314...77,157,701
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAOA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA] CTD PMID:20230807 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases expression EXP Nicotine results in increased expression of MAP2K6 mRNA CTD PMID:20426880 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAP2K7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP2K7 mRNA] CTD PMID:20230807 NCBI chr12:7,389,032...7,398,377
Ensembl chr12:2,591,219...2,604,222
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
increases phosphorylation
decreases expression
multiple interactions
increases expression
ISO
EXP
Nicotine results in increased activity of MAPK1 protein
Nicotine results in increased phosphorylation of MAPK1 protein
Nicotine results in decreased expression of MAPK1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAPK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAPK1 mRNA]
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK1 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein
Nicotine results in increased expression of MAPK1 protein modified form
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK1 protein; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of MAPK1 protein; [Nicotine co-treated with Ethanol] results in increased phosphorylation of MAPK1 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Nicotine; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in decreased activity of MAPK1 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Nicotine inhibits the reaction [Cisplatin results in increased activity of MAPK1 protein]; Nicotine inhibits the reaction [Fluorouracil results in increased phosphorylation of MAPK1 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein]; Nicotine results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Propranolol inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]
CTD PMID:12421819 PMID:12460746 PMID:15983034 PMID:17003101 PMID:17459420 More... NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 decreases expression ISO Nicotine results in decreased expression of MAPK11 mRNA CTD PMID:17135361 NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:120,218,478...120,225,395
JBrowse link
G Mapk13 mitogen activated protein kinase 13 decreases expression ISO Nicotine results in decreased expression of MAPK13 mRNA CTD PMID:17135361 NCBI chr20:6,836,979...6,847,197
Ensembl chr20:6,835,320...6,844,222
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases expression
increases expression
increases activity
decreases activity
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK3 protein; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of MAPK3 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Nicotine; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in decreased activity of MAPK3 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Nicotine inhibits the reaction [Cisplatin results in increased activity of MAPK3 protein]; Nicotine inhibits the reaction [Fluorouracil results in increased phosphorylation of MAPK3 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK3 protein]; Nicotine results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Propranolol inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]
Nicotine results in decreased expression of MAPK3 protein
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK3 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein
Nicotine results in decreased expression of MAPK3 mRNA; Nicotine results in decreased expression of MAPK3 protein
Nicotine results in increased expression of MAPK3 protein modified form
Nicotine results in increased activity of MAPK3 protein
CTD PMID:12421819 PMID:12460746 PMID:15983034 PMID:17003101 PMID:17135361 More... NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
increases expression
increases activity
ISO
EXP
Nicotine results in increased phosphorylation of MAPK8 protein
Nicotine promotes the reaction [MAPK8 protein results in increased phosphorylation of JUN protein]
Nicotine results in increased expression of MAPK8 mRNA
Nicotine results in increased activity of MAPK8 protein
Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]; Nicotine inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]
CTD PMID:11592233 PMID:17021677 PMID:20426880 PMID:20727180 PMID:21511693 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases expression EXP Nicotine results in decreased expression of MAPK9 mRNA CTD PMID:26776438 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mast2 microtubule associated serine/threonine kinase 2 increases expression ISO Nicotine results in increased expression of MAST2 mRNA CTD PMID:33640489 NCBI chr 5:135,013,006...135,152,195
Ensembl chr 5:129,775,676...129,915,606
JBrowse link
G Mbp myelin basic protein increases phosphorylation EXP Nicotine results in increased phosphorylation of MBP protein CTD PMID:15983034 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of MCL1 protein]; [Nicotine results in increased phosphorylation of MCL1 protein] which results in increased expression of and results in increased stability of MCL1 protein; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MCL1 protein] CTD PMID:19903766 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mcmdc2 minichromosome maintenance domain containing 2 increases expression EXP Nicotine results in increased expression of MCMDC2 mRNA CTD PMID:27782041 NCBI chr 5:14,071,609...14,120,435
Ensembl chr 5:9,298,101...9,338,300
JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 decreases expression ISO Nicotine results in decreased expression of MCTP1 mRNA CTD PMID:21955143 NCBI chr 2:7,798,968...8,493,596
Ensembl chr 2:6,065,808...6,761,833
JBrowse link
G Mdh2 malate dehydrogenase 2 decreases activity
multiple interactions
EXP Nicotine results in decreased activity of MDH2 protein
Folic Acid inhibits the reaction [Nicotine results in decreased activity of MDH2 protein]
CTD PMID:29972271 NCBI chr12:26,530,886...26,543,841
Ensembl chr12:20,894,262...20,907,271
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; [Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein CTD PMID:30272249 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Me1 malic enzyme 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ME1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ME1 mRNA] CTD PMID:20230807 NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Med24 mediator complex subunit 24 increases expression ISO Nicotine results in increased expression of MED24 mRNA CTD PMID:23825647 NCBI chr10:84,160,866...84,198,607
Ensembl chr10:83,664,609...83,690,123
JBrowse link
G Med28 mediator complex subunit 28 increases expression ISO Nicotine results in increased expression of MED28 mRNA CTD PMID:16949557 NCBI chr14:69,807,319...69,816,115
Ensembl chr14:65,594,647...65,603,583
JBrowse link
G Mef2c myocyte enhancer factor 2C affects expression EXP Nicotine affects the expression of MEF2C mRNA CTD PMID:20426880 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit increases expression ISO Nicotine results in increased expression of METTL3 mRNA CTD PMID:17456735 NCBI chr15:27,476,659...27,491,134
Ensembl chr15:25,003,172...25,014,041
JBrowse link
G Mgp matrix Gla protein multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in decreased expression of MGP protein CTD PMID:19910445 NCBI chr 4:171,497,472...171,500,888
Ensembl chr 4:169,766,279...169,769,667
JBrowse link
G Mir15b microRNA 15b increases methylation
decreases expression
ISO Nicotine results in increased methylation of MIR15B gene
Nicotine results in decreased expression of MIR15B mRNA
CTD PMID:33640489 NCBI chr 2:155,555,178...155,555,275
Ensembl chr 2:153,245,200...153,245,297
JBrowse link
G Mir98 microRNA 98 decreases expression
multiple interactions
ISO Nicotine results in decreased expression of MIR98 mRNA
MIR98 mRNA affects the reaction [Nicotine results in increased expression of NGF protein]; MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]; MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in decreased expression of MIR98 mRNA]
CTD PMID:33082140 NCBI chr  X:24,460,648...24,460,755
Ensembl chr  X:20,981,235...20,981,342
JBrowse link
G Mirlet7b microRNA let-7b decreases expression ISO Nicotine results in decreased expression of MIRLET7B mRNA CTD PMID:33082140 NCBI chr 7:118,684,038...118,684,122
Ensembl chr 7:116,804,186...116,804,270
JBrowse link
G Mirlet7d microRNA let-7d decreases expression ISO Nicotine results in decreased expression of MIRLET7D mRNA CTD PMID:33082140 NCBI chr17:16,322,260...16,322,357
Ensembl chr17:16,115,893...16,115,990
JBrowse link
G Mirlet7g microRNA let-7g decreases expression ISO Nicotine results in decreased expression of MIRLET7G mRNA CTD PMID:33082140 NCBI chr 8:115,701,020...115,701,107
Ensembl chr 8:106,822,280...106,822,388
JBrowse link
G Mirlet7i microRNA let-7i decreases expression ISO Nicotine results in decreased expression of MIRLET7I mRNA CTD PMID:33082140 NCBI chr 7:60,527,877...60,527,961
Ensembl chr 7:58,642,480...58,642,571
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
increases expression
decreases expression
EXP
ISO
[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein; Hexamethonium inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein]; methyllycaconitine inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein]
[Nicotine co-treated with Quartz] results in increased expression of MKI67 protein
Nicotine results in increased expression of MKI67 protein
Nicotine results in decreased expression of MKI67 protein
CTD PMID:29501575 PMID:30959089 PMID:31678612 PMID:36868510 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mlph melanophilin increases expression ISO Nicotine results in increased expression of MLPH mRNA CTD PMID:23825647 NCBI chr 9:98,955,036...98,990,566
Ensembl chr 9:91,507,591...91,542,983
JBrowse link
G Mme membrane metallo-endopeptidase increases expression ISO Nicotine results in increased expression of MME mRNA CTD PMID:23825647 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 mRNA]; lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]; Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Polymyxin B inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein]
Nicotine results in increased expression of MMP1 mRNA; Nicotine results in increased expression of MMP1 protein
CTD PMID:17151781 PMID:18986645 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased expression of MMP13 mRNA; Nicotine results in increased expression of MMP13 protein
NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP13 mRNA]
Nicotine results in decreased expression of MMP13 mRNA
CTD PMID:17151781 PMID:34153408 PMID:39098741 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
increases expression
ISO
EXP
lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP2 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP2 mRNA]
Nicotine results in decreased expression of MMP2 mRNA
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA
Nicotine results in decreased expression of MMP2 protein
Nicotine results in increased expression of MMP2 mRNA; Nicotine results in increased expression of MMP2 protein
CTD PMID:14569062 PMID:17151781 PMID:18986645 PMID:20448088 PMID:23825647 More... NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
increases expression
ISO
EXP
lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP3 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP3 mRNA]; NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP3 mRNA]
Nicotine results in increased expression of MMP3 mRNA; Nicotine results in increased expression of MMP3 protein
CTD PMID:17151781 PMID:18986645 PMID:39098741 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions
increases expression
affects response to substance
ISO CREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of MMP7 mRNA]; MMP7 promoter SNP affects the reaction [Nicotine results in increased expression of MMP7 mRNA]
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA]
Nicotine results in increased expression of MMP7 mRNA; Nicotine results in increased expression of MMP7 protein
MMP7 promoter SNP affects the susceptibility to Nicotine
CTD PMID:20061081 PMID:20230807 PMID:25847246 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
decreases expression
ISO Nicotine results in increased expression of MMP9 mRNA; Nicotine results in increased expression of MMP9 protein
MK-886 inhibits the reaction [Nicotine results in increased expression of MMP9 mRNA]
Nicotine results in decreased expression of MMP9 protein
CTD PMID:14569062 PMID:20061081 PMID:20448088 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase decreases activity
increases activity
multiple interactions
EXP Nicotine results in decreased activity of MPO protein
Nicotine results in increased activity of MPO protein
Acetylcysteine inhibits the reaction [Nicotine results in increased activity of MPO protein]; erdosteine inhibits the reaction [Nicotine results in increased activity of MPO protein]; Nicotine inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Vitamin E inhibits the reaction [Nicotine results in increased activity of MPO protein]
CTD PMID:15976189 PMID:17216608 PMID:23810507 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mrm3 mitochondrial rRNA methyltransferase 3 decreases expression ISO Nicotine results in decreased expression of MRM3 mRNA CTD PMID:17997037 NCBI chr10:61,594,155...61,623,659
Ensembl chr10:61,095,952...61,102,630
JBrowse link
G Mrpl10 mitochondrial ribosomal protein L10 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MRPL10 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL10 mRNA] CTD PMID:20230807 NCBI chr10:82,522,470...82,530,886
Ensembl chr10:82,026,031...82,034,443
JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL20 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL20 mRNA] CTD PMID:20230807 NCBI chr 5:171,690,664...171,695,728
Ensembl chr 5:166,408,962...166,413,492
JBrowse link
G Mrpl41 mitochondrial ribosomal protein L41 decreases expression ISO Nicotine results in decreased expression of MRPL41 mRNA CTD PMID:17997037 NCBI chr 3:28,178,837...28,179,755
Ensembl chr 3:7,779,143...7,782,818
JBrowse link
G Mrpl54 mitochondrial ribosomal protein L54 increases expression ISO Nicotine results in increased expression of MRPL54 mRNA CTD PMID:17456735 NCBI chr 7:9,103,525...9,106,045
Ensembl chr 7:8,452,716...8,455,321
JBrowse link
G Mrpl9 mitochondrial ribosomal protein L9 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MRPL9 mRNA] CTD PMID:20230807 NCBI chr 2:184,768,837...184,775,787
Ensembl chr 2:182,076,369...182,087,095
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO Nicotine results in increased expression of MSMO1 mRNA CTD PMID:23416264 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:24,980,697...24,998,016
JBrowse link
G Mst1 macrophage stimulating 1 decreases expression ISO Nicotine results in decreased expression of MST1 mRNA CTD PMID:18247414 NCBI chr 8:117,646,485...117,652,016
Ensembl chr 8:108,768,839...108,773,416
JBrowse link
G Msx1 msh homeobox 1 increases expression EXP Nicotine results in increased expression of MSX1 mRNA CTD PMID:20339300 NCBI chr14:77,185,802...77,189,735
Ensembl chr14:72,961,148...72,964,966
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression EXP Nicotine results in decreased expression of COX1 protein CTD PMID:28681937 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt1-ps3 metallothionein 1, pseudogene 3 increases expression ISO Nicotine results in increased expression of MT1E mRNA CTD PMID:23825647 NCBI chr17:79,695,812...79,696,200
Ensembl chr17:74,786,654...74,787,135
JBrowse link
G Mt2 metallothionein 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MT2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT2 mRNA] CTD PMID:20230807 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mt3 metallothionein 3 multiple interactions ISO [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein] CTD PMID:23933227 NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,848,755...10,850,158
JBrowse link
G Mtch1 mitochondrial carrier 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MTCH1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTCH1 mRNA] CTD PMID:20230807 NCBI chr20:7,391,558...7,415,291
Ensembl chr20:7,389,949...7,413,426
JBrowse link
G Mtf2 metal response element binding transcription factor 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTF2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTF2 mRNA] CTD PMID:20230807 NCBI chr14:1,784,218...1,828,463
Ensembl chr14:1,640,746...1,683,524
JBrowse link
G Mtif2 mitochondrial translational initiation factor 2 increases expression ISO Nicotine results in increased expression of MTIF2 mRNA CTD PMID:16949557 NCBI chr14:107,465,719...107,486,663
Ensembl chr14:103,270,039...103,285,728
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression
multiple interactions
increases phosphorylation
EXP
ISO
Nicotine results in decreased expression of MTOR mRNA
Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]
dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]]; Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]
Nicotine results in increased phosphorylation of MTOR protein
CTD PMID:26776438 PMID:30836163 PMID:31926917 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mx1 MX dynamin like GTPase 1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of MX1 mRNA CTD PMID:37951547 NCBI chr11:50,269,056...50,294,699
Ensembl chr11:36,799,660...36,823,507
JBrowse link
G Mybl2 MYB proto-oncogene like 2 decreases expression ISO Nicotine results in decreased expression of MYBL2 mRNA CTD PMID:16949557 NCBI chr 3:172,124,765...172,153,221
Ensembl chr 3:151,705,288...151,733,708
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases activity
multiple interactions
increases expression
decreases expression
ISO Nicotine results in increased activity of MYC protein
EIF4E protein affects the reaction [Nicotine results in increased expression of MYC protein]
Nicotine results in decreased expression of MYC mRNA
Nicotine results in decreased activity of and results in decreased expression of MYC protein
CTD PMID:17135361 PMID:17459420 PMID:30836163 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myh7 myosin heavy chain 7 increases expression EXP Nicotine results in increased expression of MYH7 protein CTD PMID:25280790 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Myl6 myosin light chain 6 decreases expression ISO Nicotine results in decreased expression of MYL6 mRNA CTD PMID:16949557 NCBI chr 7:1,495,301...1,498,512
Ensembl chr 7:910,774...933,791
JBrowse link
G Myo5b myosin Vb decreases expression ISO Nicotine results in decreased expression of MYO5B mRNA CTD PMID:17997037 NCBI chr18:70,313,717...70,613,918
Ensembl chr18:68,038,759...68,338,745
JBrowse link
G Myo9a myosin IXA increases expression ISO Nicotine results in increased expression of MYO9A mRNA CTD PMID:17997037 NCBI chr 8:69,044,853...69,248,094
Ensembl chr 8:60,149,234...60,350,514
JBrowse link
G Myof myoferlin increases splicing ISO Nicotine results in increased splicing of MYOF mRNA alternative form CTD PMID:23825647 NCBI chr 1:245,086,109...245,234,768
Ensembl chr 1:235,673,666...235,822,334
JBrowse link
G Mypn myopalladin decreases expression EXP Nicotine results in decreased expression of MYPN mRNA CTD PMID:27782041 NCBI chr20:25,435,554...25,521,149
Ensembl chr20:25,436,843...25,522,443
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions EXP Nicotine inhibits the reaction [Acetic Acid results in decreased expression of NAMPT protein] CTD PMID:23810507 NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Nanog Nanog homeobox increases expression
multiple interactions
ISO Nicotine results in increased expression of NANOG mRNA; Nicotine results in increased expression of NANOG protein
[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of NANOG protein; SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of NANOG mRNA]
CTD PMID:23219715 PMID:30259641 PMID:31507073 NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Ncam1 neural cell adhesion molecule 1 multiple interactions ISO [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NCAM1 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NCAM1 mRNA]
[nickel chloride co-treated with Nicotine] results in increased expression of NCAM1 mRNA
CTD PMID:23933227 PMID:37951547 NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases expression
ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Nicotine results in increased expression of NCF1 protein] CTD PMID:34171359 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 increases expression ISO Nicotine results in increased expression of NDUFA5 mRNA CTD PMID:16949557 NCBI chr 4:53,962,877...53,971,235
Ensembl chr 4:52,995,546...53,005,598
Ensembl chr 5:52,995,546...53,005,598
JBrowse link
G Ndufaf2 NADH:ubiquinone oxidoreductase complex assembly factor 2 decreases expression EXP Nicotine results in decreased expression of NDUFAF2 mRNA CTD PMID:27782041 NCBI chr 2:41,269,141...41,380,895
Ensembl chr 2:39,535,689...39,647,316
JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NDUFB5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFB5 mRNA] CTD PMID:20230807 NCBI chr 2:117,447,605...117,461,943
Ensembl chr 2:115,519,154...115,533,589
JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression EXP Nicotine results in decreased expression of NDUFB8 protein CTD PMID:28681937 NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:243,408,619...243,413,817
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO Nicotine results in increased expression of NEDD9 mRNA CTD PMID:17456735 NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,282,326...23,468,019
JBrowse link
G Nefm neurofilament medium chain increases expression ISO Nicotine results in increased expression of NEFM protein CTD PMID:20457658 NCBI chr15:46,535,857...46,541,161
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 multiple interactions ISO Nicotine promotes the reaction [NFATC2 protein results in decreased expression of CDK4 protein] CTD PMID:15231866 NCBI chr 3:177,615,189...177,747,493
Ensembl chr 3:157,198,872...157,328,325
JBrowse link
G Nfe2l1 NFE2 like bZIP transcription factor 1 increases splicing ISO Nicotine results in increased splicing of NFE2L1 mRNA alternative form CTD PMID:23825647 NCBI chr10:82,296,824...82,309,472
Ensembl chr10:81,800,366...81,832,318
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases activity
multiple interactions
decreases expression
increases expression
ISO
EXP
Nicotine results in increased activity of NFKB1 protein
Mecamylamine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]
Nicotine results in decreased expression of NFKB1 mRNA; Nicotine results in decreased expression of NFKB1 protein
Nicotine results in increased expression of NFKB1 mRNA
Vitamin K 3 inhibits the reaction [Nicotine results in increased activity of NFKB1 protein]
CTD PMID:16598845 PMID:17135361 PMID:27984197 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [Aerosols co-treated with Nicotine] results in increased expression of NFKB2 mRNA CTD PMID:33469865 NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:245,165,950...245,173,213
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases phosphorylation
increases degradation
increases expression
ISO
EXP
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; NSC 74859 inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
Nicotine results in increased phosphorylation of NFKBIA protein
Nicotine results in increased degradation of NFKBIA protein
Nicotine results in increased expression of NFKBIA mRNA
CTD PMID:17021677 PMID:17456735 PMID:20943775 PMID:34171359 PMID:34890707 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfkbie NFKB inhibitor epsilon decreases expression ISO Nicotine results in decreased expression of NFKBIE mRNA CTD PMID:18247414 NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:15,436,941...15,450,437
JBrowse link
G Nfyb nuclear transcription factor Y subunit beta decreases expression ISO Nicotine results in decreased expression of NFYB mRNA CTD PMID:18247414 NCBI chr 7:22,852,543...22,868,116
Ensembl chr 7:20,964,993...20,980,565
JBrowse link
G Ngb neuroglobin multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NGB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NGB mRNA] CTD PMID:20230807 NCBI chr 6:112,475,332...112,480,786
Ensembl chr 6:106,744,378...106,749,830
JBrowse link
G Ngf nerve growth factor increases expression
multiple interactions
ISO Nicotine results in increased expression of NGF mRNA
MIR98 mRNA affects the reaction [Nicotine results in increased expression of NGF protein]; NGF protein affects the reaction [Nicotine results in increased expression of COL1A1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of COL3A1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of EDN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of FN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of NGF mRNA]
Nicotine results in increased expression of NGF mRNA; Nicotine results in increased expression of NGF protein
Nicotine results in increased expression of and results in increased secretion of NGF protein
CTD PMID:30076938 PMID:33082140 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO Nicotine results in increased expression of NGFR mRNA CTD PMID:30076938 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nherf2 NHERF family PDZ scaffold protein 2 decreases expression ISO Nicotine results in decreased expression of NHERF2 mRNA CTD PMID:18247414 NCBI chr10:14,167,005...14,177,519
Ensembl chr10:13,662,461...13,673,049
JBrowse link
G Niban1 niban apoptosis regulator 1 increases expression ISO Nicotine results in increased expression of NIBAN1 mRNA CTD PMID:23825647 NCBI chr13:66,224,219...66,377,728
Ensembl chr13:63,674,171...63,827,729
JBrowse link
G Nin ninein increases expression
multiple interactions
ISO Nicotine results in increased expression of NIN mRNA
alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of NIN mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA]
CTD PMID:16949557 NCBI chr 6:94,261,382...94,363,679
Ensembl chr 6:88,525,742...88,627,639
JBrowse link
G Nkain3 Sodium/potassium transporting ATPase interacting 3 decreases methylation EXP Nicotine results in decreased methylation of NKAIN3 gene CTD PMID:35026373 NCBI chr 5:38,410,576...39,106,910
Ensembl chr 5:33,623,713...34,309,381
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression
ISO
EXP
Bungarotoxins inhibits the reaction [Nicotine results in increased expression of NLRP3 mRNA]; CHRNA5 protein affects the reaction [Nicotine results in increased expression of NLRP3 protein]; NLRP3 protein affects the reaction [Nicotine results in decreased expression of ACAN mRNA]; NLRP3 protein affects the reaction [Nicotine results in decreased expression of COL2A1 mRNA]; NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP13 mRNA]; NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP3 mRNA]
Nicotine results in increased expression of NLRP3 mRNA; Nicotine results in increased expression of NLRP3 protein
CTD PMID:35131329 PMID:39098741 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 decreases expression ISO Nicotine results in decreased expression of NME3 mRNA CTD PMID:18247414 NCBI chr10:14,421,922...14,422,878
Ensembl chr10:13,917,403...13,918,359
JBrowse link
G Nme6 NME/NM23 nucleoside diphosphate kinase 6 decreases expression ISO Nicotine results in decreased expression of NME6 mRNA CTD PMID:17997037 NCBI chr 8:118,708,092...118,717,756
Ensembl chr 8:109,832,589...109,839,301
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased expression of NOS2 mRNA; Nicotine results in increased expression of NOS2 protein
Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]
Nicotine results in decreased expression of NOS2 mRNA; Nicotine results in decreased expression of NOS2 protein
Nicotine promotes the reaction [NOS2 protein results in increased abundance of Nitric Oxide]
[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]; [Nicotine results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of NOS2 mRNA]; Eugenol inhibits the reaction [Nicotine results in increased expression of NOS2 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]
CTD PMID:16254210 PMID:16927020 PMID:17135361 PMID:18247414 PMID:19673871 More... NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO Nicotine results in increased expression of NOS3 mRNA CTD PMID:11166759 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Notch4 notch receptor 4 multiple interactions
decreases expression
EXP [Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein; [Saquinavir co-treated with Nicotine] results in decreased expression of NOTCH4 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]; Vitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]
Nicotine results in decreased expression of NOTCH4 protein
CTD PMID:20722969 NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,160,445...4,184,465
JBrowse link
G Nox4 NADPH oxidase 4 increases expression ISO Nicotine results in increased expression of NOX4 protein CTD PMID:20685820 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Npas3 neuronal PAS domain protein 3 decreases expression ISO Nicotine results in decreased expression of NPAS3 mRNA CTD PMID:23825647 NCBI chr 6:76,438,064...77,263,185
Ensembl chr 6:70,703,170...71,524,884
JBrowse link
G Npl N-acetylneuraminate pyruvate lyase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NPL mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NPL mRNA] CTD PMID:20230807 NCBI chr13:68,205,602...68,247,940
Ensembl chr13:65,655,118...65,697,372
JBrowse link
G Npy neuropeptide Y multiple interactions
decreases expression
increases expression
EXP Hexamethonium inhibits the reaction [Nicotine results in increased expression of NPY mRNA]
Nicotine results in decreased expression of NPY protein
Nicotine results in increased expression of NPY mRNA; Nicotine results in increased expression of NPY protein
CTD PMID:1907749 PMID:2233698 PMID:23623838 PMID:32512034 PMID:33091441 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions
decreases expression
ISO
EXP
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 protein]
Nicotine results in decreased expression of NR1H2 mRNA; Nicotine results in decreased expression of NR1H2 protein
CTD PMID:30036686 NCBI chr 1:104,178,483...104,183,863
Ensembl chr 1:95,041,967...95,047,377
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions
decreases expression
EXP
ISO
Nicotine promotes the reaction [NR1H3 protein binds to FASN promoter]; Nicotine results in increased expression of and results in increased activity of NR1H3 protein
Nicotine results in decreased expression of NR1H3 mRNA; Nicotine results in decreased expression of NR1H3 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein]
CTD PMID:24368177 PMID:30036686 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression
increases expression
EXP
ISO
Nicotine results in decreased expression of NR3C1 mRNA
Nicotine results in decreased expression of NR3C1 protein
Nicotine results in increased expression of NR3C1 mRNA; Nicotine results in increased expression of NR3C1 protein
CTD PMID:22265867 PMID:22975262 PMID:31783125 PMID:31972234 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 decreases expression EXP Nicotine results in decreased expression of NR3C2 mRNA CTD PMID:22975262 NCBI chr19:47,619,853...47,964,089
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression
decreases expression
ISO Nicotine results in increased expression of NR4A1 mRNA
Nicotine results in decreased expression of NR4A1 mRNA
CTD PMID:17456735 PMID:21955143 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of NR5A1 mRNA; Nicotine results in decreased expression of NR5A1 protein
trichostatin A inhibits the reaction [Nicotine results in decreased expression of NR5A1 mRNA]
CTD PMID:24709674 PMID:28986172 NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:22,465,502...22,486,328
JBrowse link
G Nrn1 neuritin 1 decreases expression ISO Nicotine results in decreased expression of NRN1 mRNA CTD PMID:21955143 NCBI chr17:28,335,426...28,344,354
Ensembl chr17:28,129,977...28,138,896
JBrowse link
G Nrxn3 neurexin 3 increases expression
increases methylation
ISO
EXP
Nicotine results in increased expression of NRXN3 mRNA
Nicotine results in increased methylation of NRXN3 gene
CTD PMID:21955143 PMID:32994467 NCBI chr 6:113,372,667...115,004,073
Ensembl chr 6:107,641,780...109,272,044
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NSF mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NSF mRNA] CTD PMID:20230807 NCBI chr10:89,227,937...89,357,383
Ensembl chr10:88,727,912...88,857,386
JBrowse link
G Nt5dc1 5'-nucleotidase domain containing 1 increases expression EXP Nicotine results in increased expression of NT5DC1 mRNA CTD PMID:27782041 NCBI chr20:39,660,707...39,763,647
Ensembl chr20:38,105,678...38,208,591
JBrowse link
G Ntng1 netrin G1 decreases expression ISO Nicotine results in decreased expression of NTNG1 mRNA CTD PMID:21955143 NCBI chr 2:200,151,979...200,515,031
Ensembl chr 2:197,463,945...197,826,997
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 increases expression ISO Nicotine results in increased expression of NTRK1 mRNA CTD PMID:30076938 NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of NTRK2 protein
[Nicotine co-treated with Quartz] results in increased phosphorylation of NTRK2 protein; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of NTRK2 protein]
methyllycaconitine inhibits the reaction [Nicotine results in increased expression of NTRK2 protein]
CTD PMID:16790237 PMID:36868510 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Ntsr1 neurotensin receptor 1 increases expression ISO Nicotine results in increased expression of NTSR1 mRNA CTD PMID:23825647 NCBI chr 3:187,983,778...188,033,934
Ensembl chr 3:167,606,215...167,656,377
JBrowse link
G Nudt4 nudix hydrolase 4 increases expression ISO Nicotine results in increased expression of NUDT4 mRNA CTD PMID:17997037 NCBI chr 7:32,074,978...32,091,491
Ensembl chr 7:30,188,100...30,204,615
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NUPR1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NUPR1 mRNA] CTD PMID:20230807 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:181,213,368...181,215,281
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A increases expression
multiple interactions
ISO Nicotine results in increased expression of OAS1 mRNA
Nicotine inhibits the reaction [Poly I-C results in increased expression of OAS1 mRNA]
CTD PMID:23825647 PMID:31154625 NCBI chr12:41,330,423...41,341,130
Ensembl chr12:35,669,801...35,680,517
JBrowse link
G Ogdh oxoglutarate dehydrogenase decreases activity
multiple interactions
EXP Nicotine results in decreased activity of OGDH protein
Folic Acid inhibits the reaction [Nicotine results in decreased activity of OGDH protein]
CTD PMID:29972271 NCBI chr14:85,363,949...85,431,405
Ensembl chr14:81,150,091...81,217,479
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO OGG1 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine] CTD PMID:29747151 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase increases expression ISO Nicotine results in increased expression of OGT mRNA CTD PMID:16949557 NCBI chr  X:70,811,317...70,856,123
Ensembl chr  X:66,771,349...66,816,146
JBrowse link
G Olfm4 olfactomedin 4 decreases expression ISO Nicotine results in decreased expression of OLFM4 mRNA CTD PMID:23825647 NCBI chr15:61,790,889...61,838,773
Ensembl chr15:55,407,148...55,429,681
JBrowse link
G Opalin oligodendrocytic myelin paranodal and inner loop protein decreases expression ISO Nicotine results in decreased expression of OPALIN mRNA CTD PMID:21955143 NCBI chr 1:249,840,539...249,858,423
Ensembl chr 1:239,891,142...239,908,788
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions ISO [naltrindole binds to and results in decreased activity of OPRD1 protein] which results in increased susceptibility to Nicotine CTD PMID:15778877 NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases expression ISO Nicotine results in decreased expression of OPRK1 mRNA CTD PMID:18247414 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 affects response to substance ISO OPRL1 protein affects the susceptibility to Nicotine CTD PMID:19371589 NCBI chr 3:189,209,495...189,225,406
Ensembl chr 3:168,834,003...168,839,920
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Nicotine CTD PMID:15778877 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Or4d6 olfactory receptor family 4 subfamily D member 6 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of OR4D6 mRNA CTD PMID:28065790 NCBI chr 1:218,463,801...218,464,745
Ensembl chr 1:209,037,992...209,045,985
JBrowse link
G Orc2 origin recognition complex, subunit 2 increases expression ISO Nicotine results in increased expression of ORC2 mRNA CTD PMID:16949557 NCBI chr 9:67,496,097...67,532,548
Ensembl chr 9:60,001,910...60,038,195
JBrowse link
G P3h3 prolyl 3-hydroxylase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of P3H3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of P3H3 mRNA] CTD PMID:20230807 NCBI chr 4:159,332,514...159,348,428
Ensembl chr 4:157,646,243...157,662,035
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta decreases expression EXP Nicotine results in decreased expression of P4HB protein CTD PMID:28681937 NCBI chr10:106,335,300...106,346,911
Ensembl chr10:105,836,982...105,848,500
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PAK2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA] CTD PMID:20230807 NCBI chr11:82,212,896...82,273,803
Ensembl chr11:68,707,969...68,768,816
JBrowse link
G Pank3 pantothenate kinase 3 increases expression ISO Nicotine results in increased expression of PANK3 mRNA CTD PMID:16949557 NCBI chr10:20,733,191...20,757,017
Ensembl chr10:20,229,129...20,252,955
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PARK7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PARK7 mRNA] CTD PMID:20230807 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression
ISO
EXP
Nicotine inhibits the reaction [Aflatoxin B1 results in increased expression of PARP1 protein modified form]; Nicotine inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; Nicotine inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; Nicotine inhibits the reaction [Fluorouracil results in increased cleavage of PARP1 protein]
Folic Acid inhibits the reaction [Nicotine results in decreased expression of PARP1 protein]
CTD PMID:20457658 PMID:22743290 PMID:24095863 PMID:29972271 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 increases splicing ISO Nicotine results in increased splicing of PARP4 mRNA alternative form CTD PMID:23825647 NCBI chr15:34,806,203...34,908,492
Ensembl chr15:30,686,613...30,828,810
JBrowse link
G Patj PATJ, crumbs cell polarity complex component decreases expression ISO Nicotine results in decreased expression of PATJ mRNA CTD PMID:21955143 NCBI chr 5:118,177,557...118,480,301
Ensembl chr 5:113,062,118...113,364,807
JBrowse link
G Pax3 paired box 3 decreases expression EXP Nicotine results in decreased expression of PAX3 mRNA CTD PMID:20339300 NCBI chr 9:87,015,960...87,112,531
Ensembl chr 9:79,568,634...79,664,042
JBrowse link
G Pax6 paired box 6 decreases expression EXP Nicotine results in decreased expression of PAX6 mRNA CTD PMID:28555334 NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
G Pax8 paired box 8 increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of PAX8 mRNA
Nicotine results in decreased expression of PAX8 mRNA
CTD PMID:23825647 PMID:26776438 NCBI chr 3:27,584,000...27,641,094
Ensembl chr 3:7,185,723...7,242,363
JBrowse link
G Pcf11 PCF11 cleavage and polyadenylation factor subunit increases expression ISO Nicotine results in increased expression of PCF11 mRNA CTD PMID:17456735 NCBI chr 1:156,109,724...156,136,950
Ensembl chr 1:146,697,646...146,724,124
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
decreases expression
multiple interactions
ISO Nicotine results in increased expression of PCNA protein
Nicotine results in decreased expression of PCNA protein
royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein]
CTD PMID:18448488 PMID:20106947 PMID:30896085 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pde10a phosphodiesterase 10A decreases expression ISO Nicotine results in decreased expression of PDE10A mRNA CTD PMID:21955143 NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:51,770,132...52,216,563
JBrowse link
G Pdgfa platelet derived growth factor subunit A affects expression EXP Nicotine affects the expression of PDGFA mRNA CTD PMID:20426880 NCBI chr12:20,759,366...20,780,337
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions
increases expression
increases secretion
ISO
EXP
6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased expression of PDGFB mRNA]; 6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased secretion of PDGFB protein] CTD PMID:16149045 PMID:16254210 PMID:32512034 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of PDGFRB protein
Nicotine results in decreased phosphorylation of and results in decreased activity of PDGFRB protein
6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased expression of PDGFRB protein]
CTD PMID:16149045 PMID:20447445 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PDIA6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PDIA6 mRNA] CTD PMID:20230807 NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:40,062,926...40,080,613
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 increases expression ISO Nicotine results in increased expression of PDK1 mRNA CTD PMID:31945395 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 increases expression ISO Nicotine results in increased expression of PDK2 mRNA CTD PMID:31945395 NCBI chr10:80,469,388...80,483,988
Ensembl chr10:79,972,556...79,987,085
JBrowse link
G Pdlim2 PDZ and LIM domain 2 increases expression ISO Nicotine results in increased expression of PDLIM2 mRNA CTD PMID:21955143 NCBI chr15:51,647,195...51,659,904
Ensembl chr15:45,237,477...45,249,242
JBrowse link
G Penk proenkephalin affects response to substance ISO PENK protein affects the susceptibility to Nicotine CTD PMID:15689546 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Per1 period circadian regulator 1 increases expression ISO Nicotine results in increased expression of PER1 mRNA CTD PMID:17456735 NCBI chr10:54,299,002...54,313,804
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Pes1 pescadillo ribosomal biogenesis factor 1 decreases expression ISO Nicotine results in decreased expression of PES1 mRNA CTD PMID:17997037 NCBI chr14:83,074,346...83,090,726
Ensembl chr14:78,850,709...78,867,134
JBrowse link
G Pfdn1 prefoldin subunit 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PFDN1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PFDN1 mRNA] CTD PMID:20230807 NCBI chr18:28,288,210...28,341,198
Ensembl chr18:28,014,145...28,067,064
JBrowse link
G Pfn1 profilin 1 decreases expression EXP Nicotine results in decreased expression of PFN1 mRNA CTD PMID:11478936 NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,365,262...55,527,631
JBrowse link
G Pgf placental growth factor increases expression EXP Nicotine results in increased expression of PGF mRNA CTD PMID:32512034 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:104,816,104...104,826,685
JBrowse link
G Pgr progesterone receptor decreases expression ISO Nicotine results in decreased expression of PGR mRNA CTD PMID:27552315 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Phb1 prohibitin 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHB1 mRNA] CTD PMID:20230807 NCBI chr10:81,102,043...81,114,815
Ensembl chr10:80,605,251...80,618,042
JBrowse link
G Phf21a PHD finger protein 21A increases expression ISO Nicotine results in increased expression of PHF21A mRNA CTD PMID:16949557 NCBI chr 3:98,600,933...98,791,132
Ensembl chr 3:78,194,549...78,331,865
JBrowse link
G Phf3 PHD finger protein 3 increases expression ISO Nicotine results in increased expression of PHF3 mRNA CTD PMID:16949557 NCBI chr 9:40,559,929...40,632,096
Ensembl chr 9:33,063,857...33,135,994
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression ISO Nicotine results in increased expression of PHGDH mRNA CTD PMID:23825647 NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:185,906,966...185,935,944
JBrowse link
G Phldb1 pleckstrin homology-like domain, family B, member 1 increases expression ISO Nicotine results in increased expression of PHLDB1 mRNA CTD PMID:21955143 NCBI chr 8:53,900,338...53,948,325
Ensembl chr 8:45,003,538...45,051,522
JBrowse link
G Phldb3 pleckstrin homology-like domain, family B, member 3 decreases expression EXP Nicotine results in decreased expression of PHLDB3 mRNA CTD PMID:27782041 NCBI chr 1:89,328,991...89,347,446
Ensembl chr 1:80,201,578...80,219,534
JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 affects response to substance ISO PHLPP gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr13:22,823,132...23,045,619
Ensembl chr13:22,308,548...22,530,977
JBrowse link
G Phtf1 putative homeodomain transcription factor 1 multiple interactions
decreases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHTF1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHTF1 mRNA]
Nicotine results in decreased expression of PHTF1 mRNA
CTD PMID:17456735 PMID:20230807 NCBI chr 2:194,161,343...194,249,925
Ensembl chr 2:191,473,130...191,512,078
JBrowse link
G Pick1 protein interacting with PRKCA 1 decreases expression ISO Nicotine results in decreased expression of PICK1 mRNA CTD PMID:17997037 NCBI chr 7:112,676,890...112,697,275
Ensembl chr 7:110,797,117...110,816,848
JBrowse link
G Pidd1 p53-induced death domain protein 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIDD1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIDD1 mRNA] CTD PMID:20230807 NCBI chr 1:205,966,392...205,972,359
Ensembl chr 1:196,536,834...196,542,699
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A decreases expression ISO Nicotine results in decreased expression of PIGA mRNA CTD PMID:21955143 NCBI chr  X:33,672,832...33,687,747
Ensembl chr  X:30,042,343...30,055,804
JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIGC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIGC mRNA] CTD PMID:20230807 NCBI chr13:76,876,894...76,879,420
Ensembl chr13:74,296,854...74,346,211
JBrowse link
G Pigf phosphatidylinositol glycan anchor biosynthesis, class F increases expression ISO Nicotine results in increased expression of PIGF mRNA CTD PMID:16949557 NCBI chr 6:13,343,134...13,371,237
Ensembl chr 6:7,589,570...7,639,675
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases expression ISO Nicotine results in increased expression of PIK3CA mRNA CTD PMID:16949557 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PIN1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 mRNA] CTD PMID:20230807 NCBI chr 8:27,465,538...27,477,016
Ensembl chr 8:19,189,373...19,200,785
JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIP5K1C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIP5K1C mRNA] CTD PMID:20230807 NCBI chr 7:9,048,135...9,076,751
Ensembl chr 7:8,397,406...8,425,988
JBrowse link
G Pklr pyruvate kinase L/R multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of PKLR mRNA CTD PMID:28065790 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pkn2 protein kinase N2 increases expression ISO Nicotine results in increased expression of PKN2 mRNA CTD PMID:16949557 NCBI chr 2:234,454,001...234,559,369
Ensembl chr 2:231,793,584...231,898,953
JBrowse link
G Pla2g12a phospholipase A2, group XIIA decreases expression ISO Nicotine results in decreased expression of PLA2G12A mRNA CTD PMID:17997037 NCBI chr 2:221,110,722...221,126,966
Ensembl chr 2:218,436,513...218,452,740
JBrowse link
G Pla2g4a phospholipase A2 group 4A decreases expression EXP Nicotine results in decreased expression of PLA2G4A mRNA CTD PMID:26776438 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Plaa phospholipase A2, activating protein multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PLAA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PLAA mRNA] CTD PMID:20230807 NCBI chr 5:114,544,327...114,576,023
Ensembl chr 5:109,428,265...109,460,282
JBrowse link
G Plat plasminogen activator, tissue type affects expression
increases expression
multiple interactions
ISO Nicotine affects the expression of PLAT mRNA
Nicotine results in increased expression of PLAT mRNA; Nicotine results in increased expression of PLAT protein
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of PLAT mRNA
CTD PMID:11166759 PMID:17151781 PMID:18986645 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
increases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of PLAU mRNA]
PLAU inhibits the reaction [Nicotine binds to CHRNA1 protein]
CTD PMID:19690163 PMID:20061081 PMID:23825647 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]; pyrazolanthrone inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]
Nicotine results in increased expression of PLAUR mRNA; Nicotine results in increased expression of PLAUR protein
CTD PMID:20061081 PMID:22261521 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression ISO Nicotine results in decreased expression of PLCD4 mRNA CTD PMID:21955143 NCBI chr 9:83,564,616...83,613,742
Ensembl chr 9:76,117,168...76,142,453
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP Nicotine results in increased phosphorylation of and results in increased activity of PLCG1 protein CTD PMID:15138183 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Pld1 phospholipase D1 decreases expression ISO Nicotine results in decreased expression of PLD1 mRNA CTD PMID:18247414 NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Pld2 phospholipase D2 increases expression ISO Nicotine results in increased expression of PLD2 mRNA CTD PMID:18247414 NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Plekhg1 pleckstrin homology and RhoGEF domain containing G1 affects response to substance
decreases expression
ISO PLEKHG1 gene SNP affects the susceptibility to Nicotine
Nicotine results in decreased expression of PLEKHG1 mRNA
CTD PMID:18438686 PMID:21955143 NCBI chr 1:42,612,023...42,841,727
Ensembl chr 1:40,311,221...40,434,063
JBrowse link
G Plin2 perilipin 2 decreases expression ISO Nicotine results in decreased expression of PLIN2 protein CTD PMID:31783125 NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO Nicotine results in increased expression of PLK2 mRNA CTD PMID:17456735 NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Pllp plasmolipin increases expression ISO Nicotine results in increased expression of PLLP mRNA CTD PMID:21955143 NCBI chr19:10,321,080...10,341,869
Ensembl chr19:10,315,104...10,335,892
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 decreases expression ISO Nicotine results in decreased expression of PLOD3 mRNA CTD PMID:17997037 NCBI chr12:25,313,070...25,323,631
Ensembl chr12:19,676,386...19,686,960
JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of PNMT mRNA
Nicotine results in increased expression of PNMT protein
imidacloprid promotes the reaction [Nicotine results in increased expression of PNMT protein]
CTD PMID:17498763 PMID:29246838 NCBI chr10:83,881,211...83,882,849
Ensembl chr10:83,384,923...83,386,556
JBrowse link
G Pnoc prepronociceptin affects response to substance ISO PNOC protein alternative form affects the susceptibility to Nicotine CTD PMID:19371589 NCBI chr15:43,800,240...43,827,841
Ensembl chr15:39,624,641...39,651,867
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 decreases expression
multiple interactions
EXP Nicotine results in decreased expression of PNPLA2 mRNA
[Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 protein
CTD PMID:29155039 PMID:29617909 NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:196,552,723...196,557,805
JBrowse link
G Pnpla4 patatin like phospholipase domain containing 4 decreases expression ISO Nicotine results in decreased expression of PNPLA4 mRNA CTD PMID:16949557 NCBI chr  X:46,200,351...46,205,517
Ensembl chr  X:42,305,373...42,318,552
JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PNPLA8 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PNPLA8 mRNA] CTD PMID:20230807 NCBI chr 6:67,056,783...67,118,714
Ensembl chr 6:61,329,810...61,391,734
JBrowse link
G Pomc proopiomelanocortin affects response to substance
decreases expression
affects expression
multiple interactions
increases expression
ISO
EXP
POMC protein affects the susceptibility to Nicotine
Nicotine results in decreased expression of POMC protein
Nicotine affects the expression of POMC protein
POMC protein affects the reaction [Nicotine results in increased abundance of Dopamine]
Nicotine results in increased expression of POMC protein alternative form
CTD PMID:15689546 PMID:19376143 PMID:22975262 PMID:23623838 PMID:28555334 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Pon1 paraoxonase 1 decreases activity
multiple interactions
ISO Nicotine results in decreased activity of PON1 protein
PON1 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine]
CTD PMID:24478552 PMID:29747151 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pon2 paraoxonase 2 increases expression ISO Nicotine results in increased expression of PON2 mRNA CTD PMID:16949557 NCBI chr 4:34,356,270...34,391,684
Ensembl chr 4:33,389,714...33,425,248
JBrowse link
G Pou2af1 POU class 2 homeobox associating factor 1 decreases expression ISO Nicotine results in decreased expression of POU2AF1 mRNA CTD PMID:18247414 NCBI chr 8:60,418,173...60,445,176
Ensembl chr 8:51,474,015...51,548,819
JBrowse link
G Pou2f1 POU class 2 homeobox 1 increases expression ISO Nicotine results in increased expression of POU2F1 mRNA CTD PMID:18247414 NCBI chr13:80,653,602...80,796,279
Ensembl chr13:78,130,685...78,263,363
JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of POU5F1 mRNA; Nicotine results in increased expression of POU5F1 protein
Tubocurarine inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
CTD PMID:15612475 PMID:15749260 PMID:23219715 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Ppan peter pan homolog increases expression ISO Nicotine results in increased expression of PPAN mRNA CTD PMID:17456735 NCBI chr 8:27,700,147...27,704,127
Ensembl chr 8:19,423,961...19,427,938
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Nicotine results in decreased expression of PPARA mRNA CTD PMID:29155039 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases expression
ISO Nicotine results in increased expression of PPARG mRNA
Nicotine results in decreased expression of PPARG protein
CTD PMID:31622651 PMID:33082140 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of PPARGC1A mRNA; Nicotine results in decreased expression of PPARGC1A protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A protein
CTD PMID:29155039 PMID:33091441 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PPM1B mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PPM1B mRNA] CTD PMID:20230807 NCBI chr 6:15,399,559...15,460,301
Ensembl chr 6:9,655,765...9,707,974
JBrowse link
G Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha increases expression ISO Nicotine results in increased expression of PPP2R3A mRNA CTD PMID:16949557 NCBI chr 8:110,582,479...110,720,516
Ensembl chr 8:101,704,778...101,841,502
JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPP2R3C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PPP2R3C mRNA] CTD PMID:20230807 NCBI chr 6:78,382,849...78,406,037
Ensembl chr 6:72,647,025...72,672,491
JBrowse link
G Ppp2r5d protein phosphatase 2, regulatory subunit B', delta decreases expression ISO Nicotine results in decreased expression of PPP2R5D mRNA CTD PMID:17997037 NCBI chr 9:21,767,963...21,797,997
Ensembl chr 9:14,268,745...14,300,400
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha decreases expression ISO Nicotine results in decreased expression of PPP3R1 mRNA CTD PMID:21955143 NCBI chr14:95,758,333...95,808,015
Ensembl chr14:91,604,121...91,606,907
JBrowse link
G Prdm16 PR/SET domain 16 multiple interactions
decreases expression
ISO
EXP
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PRDM16 mRNA
Nicotine results in decreased expression of PRDM16 mRNA
CTD PMID:33091441 NCBI chr 5:170,162,275...170,486,371
Ensembl chr 5:164,880,587...165,203,601
JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PRDX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PRDX3 mRNA] CTD PMID:20230807 NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Prg4 proteoglycan 4 decreases expression ISO Nicotine results in decreased expression of PRG4 mRNA CTD PMID:33640489 NCBI chr13:65,037,363...65,054,764
Ensembl chr13:62,487,257...62,504,119
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 increases expression EXP Nicotine results in increased expression of PRKAA2 mRNA CTD PMID:22265867 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PRKAB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRKAB1 mRNA] CTD PMID:20230807 NCBI chr12:46,248,971...46,259,487
Ensembl chr12:40,588,211...40,598,661
JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta increases expression ISO Nicotine results in increased expression of PRKAR2B mRNA CTD PMID:18247414 NCBI chr 6:54,291,143...54,381,639
Ensembl chr 6:48,563,662...48,653,933
JBrowse link
G Prkca protein kinase C, alpha increases activity
increases expression
ISO
EXP
Nicotine results in increased activity of PRKCA protein
Nicotine results in increased expression of PRKCA mRNA
CTD PMID:12421819 PMID:20426880 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcb protein kinase C, beta affects localization ISO Nicotine affects the localization of PRKCB protein CTD PMID:17003101 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkcd protein kinase C, delta decreases expression ISO Nicotine results in decreased expression of PRKCD mRNA CTD PMID:21955143 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkce protein kinase C, epsilon increases expression EXP Nicotine results in increased expression of PRKCE mRNA CTD PMID:20426880 NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Prkcsh PRKCSH beta subunit of glucosidase II decreases expression ISO Nicotine results in decreased expression of PRKCSH mRNA CTD PMID:16949557 NCBI chr 8:28,810,836...28,822,503
Ensembl chr 8:20,534,880...20,546,492
JBrowse link
G Prkcz protein kinase C, zeta multiple interactions
increases activity
ISO PRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein]
Nicotine results in increased activity of PRKCZ protein
CTD PMID:17525161 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases expression ISO Nicotine results in decreased expression of PRKN mRNA CTD PMID:16949557 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Prl prolactin increases secretion ISO Nicotine results in increased secretion of PRL protein CTD PMID:12893845 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prok1 prokineticin 1 decreases expression EXP Nicotine results in decreased expression of PROK1 protein CTD PMID:24368670 NCBI chr 2:197,538,747...197,547,550
Ensembl chr 2:194,853,991...194,859,250
JBrowse link
G Prom2 prominin 2 increases expression ISO Nicotine results in increased expression of PROM2 mRNA CTD PMID:23825647 NCBI chr 3:135,200,944...135,215,130
Ensembl chr 3:114,747,654...114,761,787
JBrowse link
G Prox1 prospero homeobox 1 increases expression ISO Nicotine results in increased expression of PROX1 mRNA CTD PMID:23825647 NCBI chr13:104,196,615...104,251,007
Ensembl chr13:101,669,184...101,711,183
JBrowse link
G Prpf38b pre-mRNA processing factor 38B increases expression ISO Nicotine results in increased expression of PRPF38B mRNA CTD PMID:16949557 NCBI chr 2:199,241,312...199,250,342
Ensembl chr 2:196,553,225...196,562,250
JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 increases splicing ISO Nicotine results in increased splicing of PRPS1 mRNA alternative form CTD PMID:23825647 NCBI chr  X:108,920,663...108,942,713
Ensembl chr  X:104,132,141...104,154,187
JBrowse link
G Prr18 proline rich 18 decreases expression ISO Nicotine results in decreased expression of PRR18 mRNA CTD PMID:21955143 NCBI chr 1:54,947,775...54,951,558
Ensembl chr 1:52,400,215...52,404,309
JBrowse link
G Prrc2c proline-rich coiled-coil 2C increases expression ISO Nicotine results in increased expression of PRRC2C mRNA CTD PMID:16949557 NCBI chr13:77,537,226...77,606,926
Ensembl chr13:75,004,010...75,073,643
JBrowse link
G Prss1 serine protease 1 decreases expression ISO Nicotine results in decreased expression of PRSS1 mRNA CTD PMID:16949557 NCBI chr 4:71,331,249...71,334,452
Ensembl chr 4:70,364,586...70,367,792
JBrowse link
G Psmb6 proteasome 20S subunit beta 6 decreases expression ISO Nicotine results in decreased expression of PSMB6 mRNA CTD PMID:18247414 NCBI chr10:55,737,852...55,740,218
Ensembl chr10:55,239,241...55,241,586
JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMC2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PSMC2 mRNA] CTD PMID:20230807 NCBI chr 4:14,148,080...14,162,390
Ensembl chr 4:13,255,856...13,270,185
JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 decreases expression ISO Nicotine results in decreased expression of PSMC4 mRNA CTD PMID:17456735 NCBI chr 1:92,476,690...92,485,268
Ensembl chr 1:83,348,592...83,357,494
JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMC5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PSMC5 mRNA] CTD PMID:20230807 NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,187,743...91,213,135
JBrowse link
G Psmg1 proteasome assembly chaperone 1 decreases expression ISO Nicotine results in decreased expression of PSMG1 mRNA CTD PMID:17997037 NCBI chr11:48,745,581...48,755,040
Ensembl chr11:35,276,011...35,285,622
JBrowse link
G Psmg2 proteasome assembly chaperone 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMG2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PSMG2 mRNA] CTD PMID:20230807 NCBI chr18:63,478,620...63,493,193
Ensembl chr18:61,208,678...61,259,816
JBrowse link
G Ptafr platelet-activating factor receptor decreases expression
increases expression
ISO Nicotine results in decreased expression of PTAFR mRNA
Nicotine results in increased expression of PTAFR mRNA
CTD PMID:18247414 PMID:23825647 NCBI chr 5:150,049,322...150,079,060
Ensembl chr 5:144,765,976...144,795,251
JBrowse link
G Ptbp2 polypyrimidine tract binding protein 2 increases expression ISO Nicotine results in increased expression of PTBP2 mRNA CTD PMID:16949557 NCBI chr 2:210,497,610...210,558,497
Ensembl chr 2:207,812,920...207,873,506
JBrowse link
G Pten phosphatase and tensin homolog increases expression EXP Nicotine results in increased expression of PTEN mRNA CTD PMID:11478936 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptges prostaglandin E synthase decreases expression ISO Nicotine results in decreased expression of PTGES mRNA; Nicotine results in decreased expression of PTGES protein CTD PMID:24380835 NCBI chr 3:34,575,643...34,586,987 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
increases activity
ISO
EXP
[4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; Curcumin inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of PTGS2 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; Propranolol inhibits the reaction [Nicotine results in increased activity of PTGS2 protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein]; Staurosporine inhibits the reaction [Nicotine results in increased expression of PTGS2]
Nicotine results in increased expression of PTGS2 mRNA; Nicotine results in increased expression of PTGS2 protein
Acetylcysteine inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; ferulic acid inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]
CTD PMID:16254210 PMID:17003101 PMID:17369603 PMID:17456735 PMID:18068289 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of PTK2 protein CTD PMID:30259641 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA] CTD PMID:12588870 NCBI chr 3:138,103,261...138,212,835
Ensembl chr 3:117,650,183...117,759,728
JBrowse link
G Ptx3 pentraxin 3 decreases expression ISO Nicotine results in decreased expression of PTX3 mRNA CTD PMID:18247414 NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:150,487,513...150,493,323
JBrowse link
G Pvalb parvalbumin decreases expression ISO Nicotine results in decreased expression of PVALB mRNA CTD PMID:21955143 NCBI chr 7:111,653,820...111,668,469
Ensembl chr 7:109,772,593...109,784,561
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PYCARD mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PYCARD mRNA]
Nicotine results in increased expression of PYCARD mRNA
CTD PMID:20230807 PMID:39098741 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Qki QKI, KH domain containing RNA binding increases expression ISO Nicotine results in increased expression of QKI mRNA CTD PMID:17997037 NCBI chr 1:52,935,357...53,047,338
Ensembl chr 1:50,387,698...50,498,831
JBrowse link
G Rab2a RAB2A, member RAS oncogene family multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RAB2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAB2 mRNA] CTD PMID:20230807 NCBI chr 5:26,473,424...26,537,441
Ensembl chr 5:21,676,129...21,739,899
JBrowse link
G Rab6a RAB6A, member RAS oncogene family decreases expression ISO Nicotine results in decreased expression of RAB6A mRNA CTD PMID:12588870 NCBI chr 1:164,370,033...164,422,324
Ensembl chr 1:154,958,189...154,996,715
JBrowse link
G Rab7a RAB7A, member RAS oncogene family multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAB7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RAB7 mRNA] CTD PMID:20230807 NCBI chr 4:122,019,281...122,068,067
Ensembl chr 4:120,461,963...120,506,889
JBrowse link
G Rac2 Rac family small GTPase 2 increases expression ISO Nicotine results in increased expression of RAC2 mRNA CTD PMID:23825647 NCBI chr 7:111,981,825...112,009,201
Ensembl chr 7:110,116,260...110,128,720
JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAD1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD1 mRNA] CTD PMID:20230807 NCBI chr 2:61,188,755...61,196,868
Ensembl chr 2:59,461,607...59,469,689
JBrowse link
G Rad50 RAD50 double strand break repair protein increases expression
multiple interactions
ISO Nicotine results in increased expression of RAD50 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAD50 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD50 mRNA]
CTD PMID:16949557 PMID:20230807 NCBI chr10:38,310,147...38,362,100
Ensembl chr10:37,808,726...37,861,396
JBrowse link
G Raet1e retinoic acid early transcript 1E increases expression ISO Nicotine results in increased expression of RAET1E mRNA CTD PMID:23825647 NCBI chr 1:3,474,487...3,476,431
Ensembl chr 1:1,807,644...1,812,755
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions
affects localization
increases activity
ISO Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; Bungarotoxins inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]; SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]
Nicotine affects the localization of RAF1 protein
Nicotine results in increased activity of RAF1 protein
CTD PMID:15574422 PMID:16862215 PMID:17459420 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Ramp1 receptor activity modifying protein 1 multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in increased expression of RAMP1 protein CTD PMID:19910445 NCBI chr 9:99,213,031...99,263,696
Ensembl chr 9:91,781,285...91,816,151
JBrowse link
G Ramp2 receptor activity modifying protein 2 multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in increased expression of RAMP2 protein CTD PMID:19910445 NCBI chr10:86,689,148...86,690,956
Ensembl chr10:86,188,812...86,231,829
JBrowse link
G Ramp3 receptor activity modifying protein 3 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of RAMP3 mRNA
[Cholecalciferol co-treated with Nicotine] results in increased expression of RAMP3 protein
CTD PMID:19910445 PMID:21955143 NCBI chr14:85,741,314...85,758,813
Ensembl chr14:81,527,385...81,544,902
JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 increases expression EXP Nicotine results in increased expression of RAPGEF3 mRNA CTD PMID:11478936 NCBI chr 7:130,754,883...130,777,303
Ensembl chr 7:128,875,773...128,898,521
JBrowse link
G Rarg retinoic acid receptor, gamma decreases expression ISO Nicotine results in decreased expression of RARG mRNA CTD PMID:18247414 NCBI chr 7:135,246,427...135,268,889
Ensembl chr 7:133,367,833...133,390,177
JBrowse link
G Rasa3 RAS p21 protein activator 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RASA3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RASA3 mRNA] CTD PMID:20230807 NCBI chr16:82,557,556...82,671,527
Ensembl chr16:75,855,265...75,970,804
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases phosphorylation
increases expression
decreases expression
ISO 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in increased phosphorylation of RB1 protein]; Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; Bungarotoxins inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; MK-886 inhibits the reaction [Nicotine results in increased expression of RB1 protein modified form]; Nicotine inhibits the reaction [RB1 protein binds to BIRC5 promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC6 promoter]; Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]; SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]
Nicotine results in decreased expression of RB1 protein
CTD PMID:15574422 PMID:16011614 PMID:16601104 PMID:16862215 PMID:18448488 More... NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RBBP4 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RBBP4 mRNA] CTD PMID:20230807 NCBI chr 5:146,940,207...146,959,501
Ensembl chr 5:141,638,421...141,675,284
Ensembl chr 2:141,638,421...141,675,284
JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RBBP5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RBBP5 mRNA] CTD PMID:20230807 NCBI chr13:46,464,389...46,494,244
Ensembl chr13:43,912,254...43,939,107
JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase multiple interactions
increases expression
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]
Nicotine results in increased expression of RBBP6 mRNA
CTD PMID:12588870 PMID:16949557 NCBI chr 1:186,934,563...186,966,852
Ensembl chr 1:177,503,313...177,535,678
JBrowse link
G Rbbp9 RB binding protein 9, serine hydrolase increases expression ISO Nicotine results in increased expression of RBBP9 mRNA CTD PMID:17997037 NCBI chr 3:152,378,426...152,392,370
Ensembl chr 3:131,925,341...131,932,156
JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 decreases expression ISO Nicotine results in decreased expression of RBCK1 mRNA CTD PMID:17997037 NCBI chr 3:161,249,389...161,266,321
Ensembl chr 3:140,789,080...140,806,005
JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 increases expression ISO Nicotine results in increased expression of RBFOX3 protein CTD PMID:20457658 NCBI chr10:104,218,940...104,655,863
Ensembl chr10:103,720,636...104,156,935
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 multiple interactions ISO Nicotine inhibits the reaction [RBL1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:145,807,095...145,869,330
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions ISO Nicotine inhibits the reaction [RBL2 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr19:32,049,690...32,096,467
Ensembl chr19:15,876,853...15,923,572
JBrowse link
G Rbm25 RNA binding motif protein 25 increases expression ISO Nicotine results in increased expression of RBM25 mRNA CTD PMID:16949557 NCBI chr 6:108,993,119...109,050,159
Ensembl chr 6:103,271,801...103,317,854
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
increases expression
affects localization
decreases expression
ISO
EXP
[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide co-treated with U 0126] inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of RELA protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; Nicotine affects the localization of and results in increased activity of RELA protein; Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]; U 0126 inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]
Nicotine affects the localization of RELA protein
Mecamylamine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; Nicotine inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]
Nicotine results in decreased expression of RELA mRNA; Nicotine results in decreased expression of RELA protein
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Nicotine results in decreased expression of RELA protein]; Nicotine affects the localization of and results in increased activity of RELA protein
CTD PMID:16254210 PMID:17135361 PMID:18448488 PMID:23810507 PMID:27984197 More... NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Reln reelin decreases expression EXP Nicotine results in decreased expression of RELN mRNA CTD PMID:28555334 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Rem2 RRAD and GEM like GTPase 2 decreases expression ISO Nicotine results in decreased expression of REM2 mRNA CTD PMID:21955143 NCBI chr15:31,903,972...31,908,451
Ensembl chr15:27,933,950...27,938,429
JBrowse link
G Retn resistin decreases expression EXP Nicotine results in decreased expression of RETN mRNA CTD PMID:32512034 NCBI chr12:6,508,653...6,511,115
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Rfxap regulatory factor X-associated protein decreases expression ISO Nicotine results in decreased expression of RFXAP mRNA CTD PMID:12588870 NCBI chr 2:141,158,214...141,162,397
Ensembl chr 2:139,008,055...139,012,259
JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO Nicotine results in increased expression of RGS1 mRNA CTD PMID:18247414 NCBI chr13:58,568,844...58,573,187
Ensembl chr13:56,018,554...56,022,984
JBrowse link
G Rgs13 regulator of G-protein signaling 13 decreases expression EXP Nicotine results in decreased expression of RGS13 mRNA CTD PMID:11478936 NCBI chr13:58,472,604...58,505,922
Ensembl chr13:55,922,395...55,955,648
JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RGS2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RGS2 mRNA]
Nicotine results in increased expression of RGS2 mRNA
CTD PMID:17456735 PMID:20230807 NCBI chr13:58,350,063...58,352,666
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Rhob ras homolog family member B increases expression ISO Nicotine results in increased expression of RHOB mRNA CTD PMID:17997037 NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Rig1 RNA sensor RIG-1 multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of RIGI mRNA] CTD PMID:31154625 NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:55,321,235...55,370,819
JBrowse link
G Rlbp1 retinaldehyde binding protein 1 increases expression ISO Nicotine results in increased expression of RLBP1 mRNA CTD PMID:17997037 NCBI chr 1:142,718,262...142,731,621
Ensembl chr 1:133,308,938...133,322,296
JBrowse link
G Rlf RLF zinc finger increases expression ISO Nicotine results in increased expression of RLF mRNA CTD PMID:16949557 NCBI chr 5:139,996,782...140,052,419
Ensembl chr 5:134,711,619...134,767,257
JBrowse link
G Rnd3 Rho family GTPase 3 increases splicing ISO Nicotine results in increased splicing of RND3 mRNA alternative form CTD PMID:23825647 NCBI chr 3:55,981,142...55,998,494
Ensembl chr 3:35,571,143...35,589,327
JBrowse link
G Rnf145 ring finger protein 145 decreases expression ISO Nicotine results in decreased expression of RNF145 mRNA CTD PMID:17456735 NCBI chr10:29,507,779...29,552,153
Ensembl chr10:29,011,548...29,050,781
JBrowse link
G Rph3a rabphilin 3A increases expression ISO Nicotine results in increased expression of RPH3A mRNA CTD PMID:21955143 NCBI chr12:41,203,004...41,279,536
Ensembl chr12:35,542,728...35,617,592
JBrowse link
G Rpl26 ribosomal protein L26 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RPL26 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RPL26 mRNA] CTD PMID:20230807 NCBI chr10:54,109,692...54,112,822
Ensembl chr10:53,610,421...53,613,966
JBrowse link
G Rpl5 ribosomal protein L5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RPL5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RPL5 mRNA] CTD PMID:20230807 NCBI chr14:1,988,792...1,995,236
Ensembl chr14:1,843,770...1,850,290
JBrowse link
G Rpl7a ribosomal protein L7A decreases expression ISO Nicotine results in decreased expression of RPL7A mRNA CTD PMID:18247414 NCBI chr 3:30,637,136...30,639,778
Ensembl chr 3:10,239,001...10,241,716
Ensembl chr18:10,239,001...10,241,716
JBrowse link
G Rps24 ribosomal protein S24 increases splicing ISO Nicotine results in increased splicing of RPS24 mRNA alternative form CTD PMID:23825647 NCBI chr16:95,429...101,146
Ensembl chr16:89,604...94,279
JBrowse link
G Rps25 ribosomal protein s25 increases expression ISO Nicotine results in increased expression of RPS25 mRNA CTD PMID:18247414 NCBI chr 8:53,630,333...53,632,810
Ensembl chr 8:44,733,029...44,737,271
Ensembl chr 8:44,733,029...44,737,271
JBrowse link
G Rps27a ribosomal protein S27a multiple interactions
decreases expression
ISO [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; [Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein CTD PMID:30272249 NCBI chr14:107,486,664...107,488,941
Ensembl chr14:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011
JBrowse link
G Rps5 ribosomal protein S5 decreases expression ISO Nicotine results in decreased expression of RPS5 mRNA CTD PMID:33640489 NCBI chr 1:82,610,965...82,615,262
Ensembl chr 1:73,538,776...73,543,073
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
increases phosphorylation
ISO Cholesterol inhibits the reaction [Nicotine results in increased phosphorylation of RPS6 protein] CTD PMID:31629012 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases phosphorylation
ISO [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of RPS6KB1 protein; dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of RPS6KB1 protein]]; Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of RPS6KB1 protein]
Nicotine results in increased phosphorylation of RPS6KB1 protein
CTD PMID:30259641 PMID:31926917 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 decreases expression EXP Nicotine results in decreased expression of RPS6KB2 mRNA CTD PMID:11478936 NCBI chr 1:210,880,824...210,887,556
Ensembl chr 1:201,451,265...201,458,078
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 affects response to substance ISO RPTOR gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr10:105,376,943...105,675,416
Ensembl chr10:104,878,487...105,176,983
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of RSAD2 mRNA CTD PMID:37951547 NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:43,047,658...43,059,699
JBrowse link
G Rspo3 R-spondin 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RSPO3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RSPO3 mRNA] CTD PMID:20230807 NCBI chr 1:30,112,529...30,197,267
Ensembl chr 1:28,283,914...28,367,061
JBrowse link
G RT1-Bb RT1 class II, locus Bb multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of HLA-DQB1 mRNA CTD PMID:37951547 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 multiple interactions ISO Nicotine promotes the reaction [nickel chloride results in increased expression of HLA-F mRNA] CTD PMID:37951547 NCBI chr20:3,407,880...3,484,130 JBrowse link
G RT1-Da RT1 class II, locus Da multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of HLA-DRA mRNA CTD PMID:37951547 NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,512,911...4,518,455
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of HLA-DRB1 mRNA CTD PMID:37951547 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G Runx1t1 RUNX1 partner transcriptional co-repressor 1 decreases expression ISO Nicotine results in decreased expression of RUNX1T1 mRNA CTD PMID:18247414 NCBI chr 5:31,984,946...32,136,878
Ensembl chr 5:27,187,551...27,335,592
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions
increases expression
ISO
EXP
CHRNB2 promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]
Nicotine results in increased expression of RYR2 mRNA; Nicotine results in increased expression of RYR2 protein
CREB1 protein promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; Nicotine promotes the reaction [CREB1 protein modified form binds to RYR2 promoter]
CTD PMID:21113126 NCBI chr17:63,081,527...63,667,141
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G S100a10 S100 calcium binding protein A10 decreases expression ISO Nicotine results in decreased expression of S100A10 mRNA CTD PMID:18247414 NCBI chr 2:181,904,454...181,913,101
Ensembl chr 2:179,220,887...179,229,661
JBrowse link
G S100a14 S100 calcium binding protein A14 increases expression ISO Nicotine results in increased expression of S100A14 mRNA CTD PMID:23825647 NCBI chr 2:178,305,976...178,308,004
Ensembl chr 2:176,008,395...176,010,423
JBrowse link
G S100a2 S100 calcium binding protein A2 increases expression ISO Nicotine results in increased expression of S100A2 mRNA CTD PMID:23825647 NCBI chr 2:178,374,659...178,375,903 JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression ISO Nicotine results in decreased expression of S100A6 mRNA CTD PMID:33640489 NCBI chr 2:178,398,189...178,399,763
Ensembl chr 2:176,100,899...176,102,180
JBrowse link
G S100b S100 calcium binding protein B decreases expression ISO Nicotine results in decreased expression of S100B mRNA CTD PMID:21955143 NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 decreases expression ISO Nicotine results in decreased expression of S1PR1 mRNA CTD PMID:17997037 NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:203,621,587...203,629,681
JBrowse link
G Sap30l SAP30-like decreases expression ISO Nicotine results in decreased expression of SAP30L mRNA CTD PMID:17997037 NCBI chr10:42,480,201...42,488,139
Ensembl chr10:41,979,687...41,987,658
JBrowse link
G Sar1b secretion associated, Ras related GTPase 1B increases expression ISO Nicotine results in increased expression of SAR1B mRNA CTD PMID:17997037 NCBI chr10:36,525,365...36,555,009
Ensembl chr10:36,024,382...36,054,066
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Nicotine results in increased expression of SC5D mRNA CTD PMID:17456735 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:42,632,672...42,641,273
JBrowse link
G Scaf11 SR-related CTD-associated factor 11 increases expression ISO Nicotine results in increased expression of SCAF11 mRNA CTD PMID:16949557 NCBI chr 7:129,450,872...129,503,280
Ensembl chr 7:127,574,463...127,624,101
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
decreases expression
ISO
EXP
GW 3965 inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein]
Nicotine results in decreased expression of SCARB1 mRNA; Nicotine results in decreased expression of SCARB1 protein
CTD PMID:30036686 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Nicotine results in increased expression of SCD1 mRNA
Nicotine results in increased expression of SCD mRNA
CTD PMID:17997037 PMID:23825647 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Scg2 secretogranin II increases expression EXP Nicotine results in increased expression of SCG2 mRNA CTD PMID:1907749 NCBI chr 9:88,251,531...88,257,208
Ensembl chr 9:80,803,075...80,821,097
JBrowse link
G Sdc4 syndecan 4 increases expression ISO Nicotine results in increased expression of SDC4 mRNA CTD PMID:21955143 NCBI chr 3:173,574,239...173,592,923
Ensembl chr 3:153,154,896...153,173,580
JBrowse link
G Sec61g Sec61 translocon subunit gamma increases expression ISO Nicotine results in increased expression of SEC61G mRNA CTD PMID:16949557 NCBI chr14:95,113,083...95,119,458
Ensembl chr14:90,899,768...90,906,162
Ensembl chr 9:90,899,768...90,906,162
JBrowse link
G Senp6 SUMO specific peptidase 6 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SENP6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SENP6 mRNA] CTD PMID:20230807 NCBI chr 8:89,868,115...89,951,803
Ensembl chr 8:80,989,052...81,067,170
JBrowse link
G Septin7 septin 7 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SEPTIN7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SEPTIN7 mRNA] CTD PMID:20230807 NCBI chr 8:31,995,597...32,059,069
Ensembl chr 8:23,716,030...23,783,243
JBrowse link
G Septin8 septin 8 decreases expression ISO Nicotine results in decreased expression of SEPTIN8 mRNA CTD PMID:21955143 NCBI chr10:38,185,454...38,214,502
Ensembl chr10:37,684,639...37,713,174
JBrowse link
G Serinc3 serine incorporator 3 increases expression ISO Nicotine results in increased expression of SERINC3 mRNA CTD PMID:16949557 NCBI chr 3:172,721,208...172,749,853
Ensembl chr 3:152,301,772...152,321,808
JBrowse link
G Serpinb1a serpin family B member 1A increases expression ISO Nicotine results in increased expression of SERPINB1A mRNA CTD PMID:21955143 NCBI chr17:31,799,446...31,807,853
Ensembl chr17:31,590,677...31,599,102
JBrowse link
G Serpine1 serpin family E member 1 increases secretion
increases expression
EXP
ISO
Nicotine results in increased secretion of SERPINE1 protein
Nicotine results in increased expression of SERPINE1 mRNA
CTD PMID:11166759 PMID:21596853 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Serpinf1 serpin family F member 1 decreases expression ISO Nicotine results in decreased expression of SERPINF1 mRNA
Nicotine results in decreased expression of SERPINF1 mRNA; Nicotine results in decreased expression of SERPINF1 protein
CTD PMID:21955143 PMID:26536586 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,249,708...60,262,646
JBrowse link
G Serpinh1 serpin family H member 1 decreases expression ISO Nicotine results in decreased expression of SERPINH1 mRNA CTD PMID:16949557 NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:153,643,510...153,650,801
JBrowse link
G Sertad4 SERTA domain containing 4 decreases expression ISO Nicotine results in decreased expression of SERTAD4 mRNA CTD PMID:21955143 NCBI chr13:106,889,019...106,899,777
Ensembl chr13:104,360,307...104,370,546
JBrowse link
G Sf3b6 splicing factor 3B, subunit 6 increases expression ISO Nicotine results in increased expression of SF3B6 mRNA CTD PMID:16949557 NCBI chr 6:33,545,495...33,554,537
Ensembl chr 6:27,826,029...27,835,156
JBrowse link
G Sfpq splicing factor proline and glutamine rich multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SFPQ mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SFPQ mRNA]
Nicotine results in increased expression of SFPQ mRNA
CTD PMID:17997037 PMID:20230807 NCBI chr 5:144,621,678...144,637,930
Ensembl chr 5:139,338,075...139,353,472
JBrowse link
G Sftpa1 surfactant protein A1 increases expression
multiple interactions
ISO Nicotine results in increased expression of SFTPA1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPA1 mRNA]
CTD PMID:9458815 NCBI chr16:17,042,264...17,045,770
Ensembl chr16:17,008,180...17,011,685
JBrowse link
G Sftpc surfactant protein C increases expression
multiple interactions
ISO Nicotine results in increased expression of SFTPC mRNA
[Nicotine co-treated with Quartz] results in increased expression of SFTPC protein; Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPC mRNA]
CTD PMID:9458815 PMID:36868510 NCBI chr15:52,006,274...52,009,324
Ensembl chr15:45,596,574...45,610,777
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Nicotine results in increased expression of SGK1 mRNA CTD PMID:17456735 PMID:21955143 NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 decreases expression ISO Nicotine results in decreased expression of SGPP1 mRNA CTD PMID:17997037 NCBI chr 6:100,161,024...100,182,214
Ensembl chr 6:94,425,339...94,446,534
JBrowse link
G Sh2d2a SH2 domain containing 2A increases expression ISO Nicotine results in increased expression of SH2D2A mRNA CTD PMID:23825647 NCBI chr 2:175,610,127...175,616,685
Ensembl chr 2:173,312,253...173,318,810
JBrowse link
G Sh3d19 SH3 domain containing 19 increases splicing ISO Nicotine results in increased splicing of SH3D19 mRNA alternative form CTD PMID:23825647 NCBI chr 2:173,654,234...173,814,030
Ensembl chr 2:171,356,251...171,515,561
JBrowse link
G Sh3kbp1 SH3 domain-containing kinase-binding protein 1 increases expression ISO Nicotine results in increased expression of SH3KBP1 mRNA CTD PMID:23825647 NCBI chr  X:38,686,530...39,031,658
Ensembl chr  X:34,877,866...35,222,747
JBrowse link
G Shox2 SHOX homeobox 2 decreases expression ISO Nicotine results in decreased expression of SHOX2 mRNA CTD PMID:21955143 NCBI chr 2:153,524,324...153,537,571
Ensembl chr 2:151,217,552...151,227,143
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 protein; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of CXCL8 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of IL1B protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein]
resveratrol inhibits the reaction [Nicotine results in decreased expression of SIRT1 mRNA]
CTD PMID:22687363 PMID:23199342 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor decreases expression ISO Nicotine results in decreased expression of SIVA1 mRNA CTD PMID:16949557 NCBI chr 6:137,526,416...137,530,790
Ensembl chr 6:131,705,323...131,709,690
JBrowse link
G Slbp stem-loop histone mRNA binding protein decreases expression
multiple interactions
ISO Nicotine results in decreased expression of SLBP mRNA; Nicotine results in decreased expression of SLBP protein
2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [Nicotine results in decreased expression of SLBP protein]; Bungarotoxins inhibits the reaction [Nicotine results in decreased expression of SLBP protein]; CHRNA7 affects the reaction [Nicotine results in decreased expression of SLBP protein]; CSNK2A1 affects the reaction [Nicotine results in decreased expression of SLBP protein]; Roscovitine inhibits the reaction [Nicotine results in decreased expression of SLBP protein]
CTD PMID:35929799 NCBI chr14:81,295,479...81,306,446
Ensembl chr14:77,071,632...77,081,906
JBrowse link
G Slc17a6 solute carrier family 17 member 6 decreases expression ISO
EXP
Nicotine results in decreased expression of SLC17A6 mRNA CTD PMID:21955143 PMID:28555334 NCBI chr 1:110,348,447...110,388,499
Ensembl chr 1:101,212,489...101,252,542
JBrowse link
G Slc18a3 solute carrier family 18 member A3 multiple interactions EXP Nicotine inhibits the reaction [Vanadium results in decreased expression of SLC18A3 protein]; Nicotine promotes the reaction [Bucladesine results in increased expression of SLC18A3 protein] CTD PMID:20361958 PMID:22119111 NCBI chr16:7,719,953...7,722,814 JBrowse link
G Slc19a1 solute carrier family 19 member 1 decreases expression ISO Nicotine results in decreased expression of SLC19A1 mRNA CTD PMID:19616087 NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,584,411...11,601,972
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases activity
multiple interactions
EXP Nicotine results in decreased activity of SLC1A1 protein
Tetradecanoylphorbol Acetate inhibits the reaction [Nicotine results in decreased activity of SLC1A1 protein]
CTD PMID:24355585 NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Nicotine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium] CTD PMID:27450509 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
affects response to substance
ISO Nicotine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
SLC22A2 gene SNP affects the susceptibility to Nicotine
CTD PMID:23770354 PMID:25143296 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc25a48 solute carrier family 25, member 48 decreases expression ISO Nicotine results in decreased expression of SLC25A48 mRNA CTD PMID:23825647 NCBI chr17:8,113,134...8,172,376
Ensembl chr17:8,121,175...8,160,748
JBrowse link
G Slc35a1 solute carrier family 35 member A1 increases expression ISO Nicotine results in increased expression of SLC35A1 mRNA CTD PMID:16949557 NCBI chr 5:54,021,896...54,044,677
Ensembl chr 5:49,225,602...49,248,335
JBrowse link
G Slc37a2 solute carrier family 37 member 2 increases expression ISO Nicotine results in increased expression of SLC37A2 mRNA CTD PMID:23825647 NCBI chr 8:45,134,596...45,160,551
Ensembl chr 8:36,946,930...36,971,482
JBrowse link
G Slc39a6 solute carrier family 39 member 6 increases expression ISO Nicotine results in increased expression of SLC39A6 mRNA CTD PMID:16949557 NCBI chr18:16,139,621...16,160,163
Ensembl chr18:15,864,875...15,885,417
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Nicotine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Nicotine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Slc5a7 solute carrier family 5 member 7 multiple interactions EXP Nicotine affects the reaction [Hemicholinium 3 binds to SLC5A7 protein] CTD PMID:21633116 NCBI chr 9:7,922,693...7,953,509
Ensembl chr 9:7,595,444...7,626,258
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
decreases expression
increases methylation
decreases activity
ISO
EXP
Nicotine inhibits the reaction [Paraquat results in decreased expression of SLC6A3 protein]
Nicotine results in decreased expression of SLC6A3 mRNA; Nicotine results in decreased expression of SLC6A3 protein
Nicotine results in increased methylation of SLC6A3 promoter
Nicotine results in decreased activity of SLC6A3 protein
Dihydro-beta-Erythroidine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein]; Mecamylamine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein]
CTD PMID:17227438 PMID:23999947 PMID:31945395 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc6a7 solute carrier family 6 member 7 decreases expression ISO Nicotine results in decreased expression of SLC6A7 mRNA CTD PMID:21955143 NCBI chr18:56,718,849...56,737,702
Ensembl chr18:54,448,464...54,467,319
JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO Nicotine results in increased expression of SLC7A5 mRNA CTD PMID:23825647 NCBI chr19:66,843,808...66,872,412
Ensembl chr19:49,935,220...49,963,823
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 increases expression ISO Nicotine results in increased expression of SLCO2A1 mRNA CTD PMID:23825647 NCBI chr 8:112,467,739...112,551,923
Ensembl chr 8:103,588,916...103,672,546
JBrowse link
G Smad1 SMAD family member 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMAD1 mRNA] CTD PMID:20230807 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:28,513,131...28,573,651
JBrowse link
G Smad2 SMAD family member 2 decreases expression EXP Nicotine results in decreased expression of SMAD2 mRNA; Nicotine results in decreased expression of SMAD2 protein CTD PMID:29660438 PMID:31299270 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases expression
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SMAD3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA]
Nicotine results in increased expression of and results in increased phosphorylation of SMAD3 protein
Nicotine results in decreased expression of SMAD3 mRNA
CTD PMID:20230807 PMID:22691361 PMID:29660438 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smad9 SMAD family member 9 increases expression ISO Nicotine results in increased expression of SMAD9 mRNA CTD PMID:18247414 NCBI chr 2:141,106,668...141,156,477
Ensembl chr 2:138,986,471...139,006,307
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SMPD3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMPD3 mRNA] CTD PMID:20230807 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:34,162,341...34,245,749
JBrowse link
G Snai1 snail family transcriptional repressor 1 increases expression
multiple interactions
increases response to substance
ISO
EXP
Nicotine results in increased expression of SNAI1 mRNA; Nicotine results in increased expression of SNAI1 protein
SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 protein]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 protein]
SNAI1 results in increased susceptibility to Nicotine
SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA]; SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of NANOG mRNA]; SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
CTD PMID:23219715 PMID:34245815 NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of SNAI2 mRNA
Nicotine results in decreased expression of SNAI2 mRNA
CTD PMID:20339300 PMID:23219715 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Snapc3 small nuclear RNA activating complex, polypeptide 3 increases expression ISO Nicotine results in increased expression of SNAPC3 mRNA CTD PMID:16949557 NCBI chr 5:102,863,867...102,890,573
Ensembl chr 5:97,817,947...97,844,650
JBrowse link
G Snca synuclein alpha increases expression ISO Nicotine results in increased expression of SNCA mRNA CTD PMID:18247414 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sncg synuclein, gamma multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SNCG mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCG mRNA] CTD PMID:20230807 NCBI chr16:9,706,765...9,712,072
Ensembl chr16:9,700,514...9,705,368
JBrowse link
G Snord8 small nucleolar RNA, C/D box 8 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of SNORD8 mRNA CTD PMID:28065790 NCBI chr15:27,391,331...27,391,440
Ensembl chr15:24,917,836...24,917,945
JBrowse link
G Snrk SNF related kinase decreases expression ISO Nicotine results in decreased expression of SNRK mRNA CTD PMID:17997037 NCBI chr 8:130,657,204...130,711,461
Ensembl chr 8:121,793,302...121,832,323
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP Nicotine results in increased expression of SOCS3 mRNA CTD PMID:29155039 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of SOD1 protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 protein
CTD PMID:16627626 PMID:29617909 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
multiple interactions
increases expression
ISO
EXP
Nicotine results in decreased expression of SOD2 protein
SOD2 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine]
[Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD2 protein
resveratrol inhibits the reaction [Nicotine results in decreased expression of SOD2 protein]
Nicotine results in increased expression of SOD2 protein
CTD PMID:18343235 PMID:22687363 PMID:28681937 PMID:29617909 PMID:29747151 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 multiple interactions
increases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA] CTD PMID:16949557 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Sost sclerostin increases expression ISO Nicotine results in increased expression of SOST mRNA CTD PMID:33640489 NCBI chr10:87,412,722...87,415,766
Ensembl chr10:86,911,517...86,915,561
JBrowse link
G Sowaha sosondowah ankyrin repeat domain family member A decreases expression ISO Nicotine results in decreased expression of SOWAHA mRNA CTD PMID:21955143 NCBI chr10:38,142,633...38,146,199
Ensembl chr10:37,643,444...37,645,102
JBrowse link
G Sox18 SRY-box transcription factor 18 decreases expression ISO Nicotine results in decreased expression of SOX18 mRNA CTD PMID:17456735 NCBI chr 3:189,163,000...189,164,802
Ensembl chr 3:168,785,490...168,787,290
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression EXP Nicotine results in decreased expression of SOX9 mRNA; Nicotine results in decreased expression of SOX9 protein CTD PMID:29660438 PMID:31299270 NCBI chr10:98,305,744...98,311,250
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA4 protein binds to SP1 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine promotes the reaction [GATA6 protein binds to SP1 protein] CTD PMID:24089524 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Spag9 sperm associated antigen 9 increases expression ISO Nicotine results in increased expression of SPAG9 mRNA CTD PMID:16949557 NCBI chr10:79,440,311...79,574,709
Ensembl chr10:78,943,479...79,077,797
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of SPP1 protein
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein]
CTD PMID:11425648 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sprr2d small proline-rich protein 2D increases expression ISO Nicotine results in increased expression of SPRR2D mRNA CTD PMID:23825647 NCBI chr 2:180,565,685...180,566,282
Ensembl chr 2:177,870,434...177,870,679
JBrowse link
G Sptlc3 serine palmitoyltransferase, long chain base subunit 3 increases expression ISO Nicotine results in increased expression of SPTLC3 mRNA CTD PMID:23825647 NCBI chr 3:147,301,570...147,431,696
Ensembl chr 3:126,847,878...126,978,010
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased expression of SQSTM1 protein]]; Nicotine promotes the reaction [Dextran Sulfate results in decreased expression of SQSTM1 protein]
Nicotine results in increased expression of SQSTM1 protein
CTD PMID:31926917 PMID:33010382 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation
multiple interactions
ISO Nicotine results in increased phosphorylation of SRC protein
ARRB1 protein affects the reaction [Nicotine results in increased phosphorylation of and results in increased activity of SRC protein]; Nicotine results in increased phosphorylation of and results in increased activity of SRC protein; RTKI cpd inhibits the reaction [Nicotine results in increased phosphorylation of SRC protein]; SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]
CTD PMID:14569062 PMID:16862215 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
increases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of SREBF1 mRNA
Nicotine results in increased expression of SREBF1 mRNA
[Nicotine results in increased abundance of Cotinine] which results in increased expression of SREBF1 mRNA
CTD PMID:18247414 PMID:29155039 PMID:29617909 PMID:31622651 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srgap2 SLIT-ROBO Rho GTPase activating protein 2 decreases expression ISO Nicotine results in decreased expression of SRGAP2 mRNA CTD PMID:17997037 NCBI chr13:45,298,192...45,519,330
Ensembl chr13:42,745,947...42,967,058
JBrowse link
G Srp9 signal recognition particle 9 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SRP9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SRP9 mRNA] CTD PMID:20230807 NCBI chr13:96,364,253...96,372,393
Ensembl chr13:93,832,580...93,840,720
JBrowse link
G Srpx2 sushi-repeat-containing protein, X-linked 2 increases expression ISO Nicotine results in increased expression of SRPX2 mRNA CTD PMID:23825647 NCBI chr  X:101,399,748...101,425,486
Ensembl chr  X:97,106,561...97,132,195
JBrowse link
G Sst somatostatin decreases expression ISO Nicotine results in decreased expression of SST mRNA CTD PMID:17997037 NCBI chr11:90,461,546...90,462,823
Ensembl chr11:76,956,896...76,958,173
JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 decreases expression ISO Nicotine results in decreased expression of ST8SIA3 mRNA CTD PMID:21955143 NCBI chr18:60,024,555...60,031,050
Ensembl chr18:57,754,347...57,760,839
JBrowse link
G Stac SH3 and cysteine rich domain increases expression ISO Nicotine results in increased expression of STAC mRNA CTD PMID:23825647 NCBI chr 8:120,409,165...120,531,394
Ensembl chr 8:111,530,800...111,654,008
JBrowse link
G Star steroidogenic acute regulatory protein increases methylation
decreases expression
multiple interactions
ISO
EXP
Nicotine results in increased methylation of STAR promoter
Nicotine results in decreased expression of STAR mRNA; Nicotine results in decreased expression of STAR protein
LMK-235 inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; LMK-235 inhibits the reaction [Nicotine results in decreased expression of STAR protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR protein]
Taurine inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Taurine inhibits the reaction [Nicotine results in decreased expression of STAR protein]
Nicotine results in decreased expression of STAR; Nicotine results in decreased expression of STAR mRNA; Nicotine results in decreased expression of STAR protein
trichostatin A inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]
CTD PMID:20498001 PMID:21971485 PMID:22265867 PMID:24709674 PMID:31846720 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA] CTD PMID:31154625 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat2 signal transducer and activator of transcription 2 decreases expression ISO Nicotine results in decreased expression of STAT2 mRNA CTD PMID:18247414 NCBI chr 7:1,287,025...1,302,858
Ensembl chr 7:702,495...718,967
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
affects expression
increases response to substance
increases activity
ISO
EXP
[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide co-treated with U 0126] inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [Nicotine co-treated with Lipopolysaccharides] results in increased phosphorylation of STAT3 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; CHRNA5 protein affects the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [Cisplatin results in decreased activity of STAT3 protein]; Nicotine inhibits the reaction [Paclitaxel results in decreased activity of STAT3 protein]; Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]; Nicotine promotes the reaction [STAT3 protein binds to ZFP36 promoter]; Nicotine results in increased phosphorylation of and results in increased activity of STAT3 protein; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; U 0126 inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; U 0126 inhibits the reaction [Nicotine results in increased activity of STAT3 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]
[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form; Bungarotoxins inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Hexamethonium inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form]; methyllycaconitine inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form]
Nicotine affects the expression of STAT3 mRNA
STAT3 protein results in increased susceptibility to Nicotine
HMOX1 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [Quartz results in decreased phosphorylation of STAT3 protein]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; STAT3 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased phosphorylation of STAT3 protein]; ZFP36 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; zinc protoporphyrin inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]
STAT3 results in increased susceptibility to Nicotine
CTD PMID:18448488 PMID:20106947 PMID:20943775 PMID:21606497 PMID:24095726 More... NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stat5a signal transducer and activator of transcription 5A decreases phosphorylation
multiple interactions
ISO Nicotine results in decreased phosphorylation of STAT5 protein
Cholesterol inhibits the reaction [Nicotine results in decreased phosphorylation of STAT5 protein]
CTD PMID:31629012 PMID:31783125 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat5b signal transducer and activator of transcription 5B increases expression ISO Nicotine results in increased expression of STAT5B mRNA CTD PMID:18805435 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Stat6 signal transducer and activator of transcription 6 increases expression ISO Nicotine results in increased expression of STAT6 mRNA CTD PMID:18805435 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:63,479,642...63,498,495
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Nicotine results in increased expression of STC2 mRNA CTD PMID:16949557 NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Steap1 STEAP family member 1 increases expression ISO Nicotine results in increased expression of STEAP1 mRNA CTD PMID:23825647 NCBI chr 4:29,231,809...29,242,317
Ensembl chr 4:28,276,909...28,287,479
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression
multiple interactions
ISO Nicotine results in decreased expression of STIP1 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of STIP1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STIP1 mRNA]
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA]
CTD PMID:16949557 PMID:20230807 NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:204,178,932...204,228,476
JBrowse link
G Stk25 serine/threonine kinase 25 increases expression ISO Nicotine results in increased expression of STK25 mRNA CTD PMID:18247414 NCBI chr 9:101,609,218...101,621,458
Ensembl chr 9:94,161,836...94,174,244
JBrowse link
G Strip2 striatin interacting protein 2 decreases expression ISO Nicotine results in decreased expression of STRIP2 mRNA CTD PMID:21955143 NCBI chr 4:59,503,478...59,545,745
Ensembl chr 4:58,536,055...58,578,291
JBrowse link
G Stx4 syntaxin 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of STX4A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STX4A mRNA] CTD PMID:20230807 NCBI chr 1:191,880,549...191,890,333
Ensembl chr 1:182,451,117...182,459,979
JBrowse link
G Stxbp3 syntaxin binding protein 3 increases expression ISO Nicotine results in increased expression of STXBP3 mRNA CTD PMID:16949557 NCBI chr 2:199,130,725...199,173,823
Ensembl chr 2:196,442,634...196,485,671
JBrowse link
G Sub1 SUB1 regulator of transcription increases expression ISO Nicotine results in increased expression of SUB1 mRNA CTD PMID:17456735 NCBI chr 2:62,735,379...62,747,545
Ensembl chr 2:61,005,666...61,020,436
Ensembl chr 2:61,005,666...61,020,436
JBrowse link
G Supt4h1 SPT4 homolog, DSIF elongation factor subunit decreases expression ISO Nicotine results in decreased expression of SUPT4H1 mRNA CTD PMID:18247414 NCBI chr10:73,036,560...73,042,821
Ensembl chr10:72,539,382...72,545,831
JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 decreases expression ISO Nicotine results in decreased expression of SYNE1 mRNA CTD PMID:21955143 NCBI chr 1:43,917,640...44,388,802
Ensembl chr 1:41,512,030...41,983,322
JBrowse link
G Syngr2 synaptogyrin 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SYNGR2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SYNGR2 mRNA] CTD PMID:20230807 NCBI chr10:103,528,599...103,533,167
Ensembl chr10:103,029,917...103,034,473
JBrowse link
G Synpo synaptopodin increases expression ISO Nicotine results in increased expression of SYNPO mRNA CTD PMID:23825647 NCBI chr18:56,326,369...56,347,359
Ensembl chr18:54,026,152...54,102,126
JBrowse link
G Syt3 synaptotagmin 3 increases methylation EXP Nicotine results in increased methylation of SYT3 gene CTD PMID:32994467 NCBI chr 1:104,017,341...104,032,046
Ensembl chr 1:94,881,247...94,895,246
JBrowse link
G Syt4 synaptotagmin 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SYT4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SYT4 mRNA] CTD PMID:20230807 NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,038,378...23,046,332
JBrowse link
G Syt9 synaptotagmin 9 decreases expression ISO Nicotine results in decreased expression of SYT9 mRNA CTD PMID:21955143 NCBI chr 1:170,687,666...170,868,146
Ensembl chr 1:161,275,734...161,455,007
JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 decreases methylation EXP Nicotine results in decreased methylation of TAB1 gene CTD PMID:35026373 NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:111,686,371...111,707,058
JBrowse link
G Tacr1 tachykinin receptor 1 decreases expression
increases expression
multiple interactions
EXP Nicotine results in decreased expression of TACR1 mRNA; Nicotine results in decreased expression of TACR1 protein
Nicotine results in increased expression of TACR1 mRNA; Nicotine results in increased expression of TACR1 protein
Mecamylamine inhibits the reaction [Nicotine results in increased expression of TACR1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of TACR1 protein]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 mRNA]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 protein]
CTD PMID:26524655 PMID:27329243 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tada2b transcriptional adaptor 2B increases expression EXP Nicotine results in increased expression of TADA2B mRNA CTD PMID:27782041 NCBI chr14:78,503,939...78,523,715
Ensembl chr14:74,279,217...74,290,755
JBrowse link
G Tagln2 transgelin 2 decreases expression ISO Nicotine results in decreased expression of TAGLN2 mRNA CTD PMID:16949557 NCBI chr13:87,499,350...87,506,328
Ensembl chr13:84,967,009...84,973,972
JBrowse link
G Taok1 TAO kinase 1 increases expression ISO Nicotine results in increased expression of TAOK1 mRNA CTD PMID:16949557 NCBI chr10:62,871,198...62,989,049
Ensembl chr10:62,381,404...62,465,766
JBrowse link
G Tbxa2r thromboxane A2 receptor increases activity EXP Nicotine results in increased activity of TBXA2R protein CTD PMID:21316381 NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:8,383,378...8,388,176
JBrowse link
G Tent4a terminal nucleotidyltransferase 4A increases splicing ISO Nicotine results in increased splicing of TENT4A mRNA alternative form CTD PMID:23825647 NCBI chr 1:35,594,380...35,627,836
Ensembl chr 1:33,765,672...33,799,433
JBrowse link
G Tex264 testis expressed 264 decreases expression ISO Nicotine results in decreased expression of TEX264 mRNA CTD PMID:17997037 NCBI chr 8:116,174,517...116,201,578
Ensembl chr 8:107,295,806...107,323,232
JBrowse link
G Tf transferrin multiple interactions ISO [Nicotine co-treated with Glycerol co-treated with Propylene Glycol] results in increased secretion of TF protein CTD PMID:36372912 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfdp1 transcription factor Dp-1 multiple interactions
increases expression
decreases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of TFDP1 protein]
Nicotine results in increased expression of TFDP1 mRNA
Nicotine results in decreased expression of TFDP1 mRNA
CTD PMID:17997037 PMID:18247414 PMID:20061081 NCBI chr16:82,864,220...82,903,166
Ensembl chr16:76,162,043...76,200,817
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 multiple interactions
increases expression
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of TFPI2 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of TFPI2 mRNA]
Nicotine results in increased expression of TFPI2 mRNA
CTD PMID:12588870 NCBI chr 4:32,936,462...32,941,385
Ensembl chr 4:31,982,178...31,986,600
JBrowse link
G Tfrc transferrin receptor increases expression
multiple interactions
ISO Nicotine results in increased expression of TFRC mRNA
[Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased expression of TFRC mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TFRC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TFRC mRNA]
CTD PMID:16949557 PMID:20230807 PMID:28065790 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
affects expression
increases expression
ISO
EXP
Nicotine results in decreased expression of TGFB1 mRNA
Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
Nicotine affects the expression of TGFB1 mRNA
Nicotine results in increased expression of TGFB1 mRNA
Nicotine results in increased expression of TGFB1 protein
Nicotine results in decreased expression of TGFB1 mRNA; Nicotine results in decreased expression of TGFB1 protein
CTD PMID:21237301 PMID:22691361 PMID:25280790 PMID:29660438 PMID:31299270 More... NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression EXP Nicotine results in decreased expression of TGFBR1 mRNA; Nicotine results in decreased expression of TGFBR1 protein CTD PMID:29660438 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression EXP Nicotine results in decreased expression of TGFBR2 mRNA CTD PMID:28555334 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of TH mRNA; Nicotine results in increased expression of TH protein
[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; [conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with exoenzyme C3, Clostridium botulinum] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; conotoxin AuIB inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; conotoxin AuIB inhibits the reaction [Nicotine results in increased expression of TH mRNA]; exoenzyme C3, Clostridium botulinum inhibits the reaction [Nicotine results in increased expression of TH mRNA]; imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]; imidacloprid promotes the reaction [Nicotine results in increased expression of TH protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Nicotine results in increased expression of TH mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of TH mRNA]; ZM 241385 inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; ZM 241385 inhibits the reaction [Nicotine results in increased expression of TH mRNA]
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TH mRNA; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]
CTD PMID:17498763 PMID:19594327 PMID:20230807 PMID:23933227 PMID:28082123 More... NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thoc1 THO complex subunit 1 increases expression ISO Nicotine results in increased expression of THOC1 mRNA CTD PMID:16949557 NCBI chr18:1,253,041...1,291,956
Ensembl chr18:983,824...1,019,114
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression
increases expression
multiple interactions
ISO
EXP
Nicotine affects the expression of TIMP1 mRNA
Nicotine results in increased expression of TIMP1 mRNA
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP1 mRNA
CTD PMID:18986645 PMID:34153408 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression EXP Nicotine results in increased expression of TIMP2 mRNA CTD PMID:34153408 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 affects expression
multiple interactions
ISO Nicotine affects the expression of TIMP3 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIMP3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TIMP3 mRNA]
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP3 mRNA
CTD PMID:18986645 PMID:20230807 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:17,521,919...17,571,839
JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 multiple interactions
decreases expression
affects expression
ISO
EXP
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP4 mRNA
Nicotine results in decreased expression of TIMP4 protein
Nicotine affects the expression of TIMP4 mRNA
CTD PMID:18986645 PMID:28681937 NCBI chr 4:149,978,667...149,985,350
Ensembl chr 4:148,304,490...148,312,558
JBrowse link
G Tinagl1 tubulointerstitial nephritis antigen-like 1 increases expression ISO Nicotine results in increased expression of TINAGL1 mRNA CTD PMID:23825647 NCBI chr 5:147,797,884...147,807,925
Ensembl chr 5:142,513,714...142,523,720
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression ISO Nicotine results in increased expression of TIPARP mRNA CTD PMID:17456735 NCBI chr 2:152,063,769...152,090,414
Ensembl chr 2:149,753,682...149,780,327
JBrowse link
G Tirap TIR domain containing adaptor protein multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIRAP mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TIRAP mRNA] CTD PMID:20230807 NCBI chr 8:41,789,557...41,805,903
Ensembl chr 8:33,531,725...33,547,432
JBrowse link
G Tjp1 tight junction protein 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of TJP1 protein
[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein; [Saquinavir co-treated with Nicotine] results in decreased expression of TJP1 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]; Vitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of TJP1 protein]
CTD PMID:18844224 PMID:20722969 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP
ISO
Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 mRNA]
[Aerosols co-treated with Nicotine] results in increased expression of TLR4 mRNA
CTD PMID:27984197 PMID:33469865 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 increases expression ISO Nicotine results in increased expression of TMCC3 mRNA CTD PMID:21955143 NCBI chr 7:30,781,452...31,058,888
Ensembl chr 7:28,893,967...29,171,926
JBrowse link
G Tmem125 transmembrane protein 125 increases expression ISO Nicotine results in increased expression of TMEM125 mRNA CTD PMID:21955143 NCBI chr 5:137,348,545...137,349,949
Ensembl chr 5:132,059,554...132,079,297
Ensembl chr 5:132,059,554...132,079,297
JBrowse link
G Tmem163 transmembrane protein 163 decreases expression ISO Nicotine results in decreased expression of TMEM163 mRNA CTD PMID:21955143 NCBI chr13:41,520,595...41,693,938
Ensembl chr13:38,968,101...39,141,452
JBrowse link
G Tmem222 transmembrane protein 222 increases splicing ISO Nicotine results in increased splicing of TMEM222 mRNA alternative form CTD PMID:23825647 NCBI chr 5:150,749,746...150,763,031
Ensembl chr 5:145,465,847...145,484,491
JBrowse link
G Tmem41b transmembrane protein 41B increases expression ISO Nicotine results in increased expression of TMEM41B mRNA CTD PMID:16949557 NCBI chr 1:173,447,362...173,461,760
Ensembl chr 1:164,012,592...164,026,933
JBrowse link
G Tmem63a transmembrane protein 63a increases expression ISO Nicotine results in increased expression of TMEM63A mRNA CTD PMID:21955143 NCBI chr13:95,194,323...95,227,944
Ensembl chr13:92,663,968...92,696,183
JBrowse link
G Tmem97 transmembrane protein 97 increases expression ISO Nicotine results in increased expression of TMEM97 mRNA CTD PMID:17997037 NCBI chr10:63,936,276...63,945,359
Ensembl chr10:63,438,222...63,589,730
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
increases secretion
decreases expression
increases expression
increases degradation
ISO
EXP
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein; Bungarotoxins inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]]; methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Nicotine promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA]; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein]; ZFP36 mRNA affects the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; ZFP36 mRNA affects the reaction [Nicotine results in increased degradation of TNF mRNA]
Nicotine affects the expression of TNF mRNA
Nicotine results in increased secretion of TNF protein
Nicotine results in decreased expression of TNF protein
Nicotine results in increased expression of TNF mRNA; Nicotine results in increased expression of TNF protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of TNF mRNA; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of TNF protein]; erdosteine inhibits the reaction [Nicotine results in increased expression of TNF protein]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of TNF mRNA]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Vitamin E inhibits the reaction [Nicotine results in increased expression of TNF protein]
Acetylcysteine inhibits the reaction [Nicotine results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Nicotine results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of TNF protein]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Nicotine inhibits the reaction [IFNG protein results in increased expression of TNF mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; STAT3 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
CTD PMID:15135227 PMID:16254210 PMID:17216608 PMID:20426880 PMID:21237301 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression
multiple interactions
EXP Nicotine results in increased expression of TNFRSF11B mRNA
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of TNFRSF11B mRNA]
CTD PMID:29981921 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression
decreases expression
EXP
ISO
Nicotine results in increased expression of TNFRSF1A mRNA
Nicotine results in decreased expression of TNFRSF1A mRNA
CTD PMID:18247414 PMID:20426880 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases expression
EXP Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of TNFSF11 mRNA] CTD PMID:29981921 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tnk2 tyrosine kinase, non-receptor, 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TNK2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNK2 mRNA] CTD PMID:20230807 NCBI chr11:81,619,795...81,659,074
Ensembl chr11:68,114,726...68,154,009
JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 increases expression ISO Nicotine results in increased expression of TOMM70A mRNA CTD PMID:21955143 NCBI chr11:56,847,837...56,886,302
Ensembl chr11:43,377,216...43,417,202
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 increases expression ISO Nicotine results in increased expression of TOPBP1 mRNA CTD PMID:16949557 NCBI chr 8:112,766,791...112,815,203
Ensembl chr 8:103,887,865...103,931,674
JBrowse link
G Tp53 tumor protein p53 decreases expression
increases expression
multiple interactions
affects response to substance
affects expression
ISO
EXP
Nicotine results in decreased expression of TP53 mRNA; Nicotine results in decreased expression of TP53 protein
Nicotine results in increased expression of TRP53 mRNA; Nicotine results in increased expression of TRP53 protein
Nicotine results in decreased expression of TRP53 protein
[Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TRP53 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TRP53 protein]; royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA]
Nicotine results in increased expression of TP53 mRNA
TP53 protein affects the susceptibility to Nicotine
Nicotine affects the expression of TP53 mRNA
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of TP53 protein]; [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of TP53 protein modified form]; Nicotine inhibits the reaction [Cisplatin results in increased expression of TP53 protein]; Nicotine inhibits the reaction [Gemcitabine results in increased expression of TP53 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased expression of TP53 protein]; Rosiglitazone inhibits the reaction [Nicotine results in decreased expression of TP53 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]
Nicotine results in increased expression of TP53 protein
CTD PMID:10837795 PMID:15983034 PMID:16011614 PMID:16601104 PMID:18247414 More... NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Nicotine] results in increased expression of TRP53INP1 mRNA CTD PMID:20230807 NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:24,260,568...24,267,968
JBrowse link
G Tph2 tryptophan hydroxylase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPH2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPH2 mRNA] CTD PMID:20230807 NCBI chr 7:52,571,909...52,676,305
Ensembl chr 7:50,685,694...50,789,424
JBrowse link
G Tpp2 tripeptidyl peptidase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPP2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPP2 mRNA] CTD PMID:20230807 NCBI chr 9:53,538,788...53,620,253
Ensembl chr 9:46,046,632...46,128,157
JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression ISO Nicotine results in increased expression of TPR mRNA CTD PMID:16949557 NCBI chr13:64,974,419...65,037,604
Ensembl chr13:62,424,312...62,487,496
JBrowse link
G Tra2a transformer 2 alpha increases expression ISO Nicotine results in increased expression of TRA2A mRNA CTD PMID:16949557 NCBI chr 4:79,551,699...79,570,621
Ensembl chr 4:78,220,883...78,239,712
JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 increases expression ISO Nicotine results in increased expression of TREM1 mRNA CTD PMID:23825647 NCBI chr 9:20,259,227...20,276,879
Ensembl chr 9:12,763,819...12,779,203
JBrowse link
G Trib2 tribbles pseudokinase 2 increases expression ISO Nicotine results in increased expression of TRIB2 mRNA CTD PMID:16949557 NCBI chr 6:44,274,762...44,299,139
Ensembl chr 6:38,545,975...38,569,370
JBrowse link
G Trim28 tripartite motif-containing 28 increases splicing ISO Nicotine results in increased splicing of TRIM28 mRNA alternative form CTD PMID:23825647 NCBI chr 1:82,724,842...82,731,566
Ensembl chr 1:73,652,709...73,659,380
JBrowse link
G Trip11 thyroid hormone receptor interactor 11 increases expression ISO Nicotine results in increased expression of TRIP11 mRNA CTD PMID:16949557 NCBI chr 6:126,760,263...126,832,619
Ensembl chr 6:120,998,733...121,067,781
JBrowse link
G Trnp1 TMF1-regulated nuclear protein 1 increases expression ISO Nicotine results in increased expression of TRNP1 mRNA CTD PMID:23825647 NCBI chr 5:150,990,312...150,997,148
Ensembl chr 5:145,706,094...145,713,272
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
affects response to substance
increases expression
increases activity
EXP Mecamylamine inhibits the reaction [Nicotine results in increased expression of TRPV1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of TRPV1 protein]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 mRNA]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 protein]
TRPV1 protein affects the susceptibility to Nicotine
Nicotine results in increased expression of TRPV1 mRNA; Nicotine results in increased expression of TRPV1 protein
Nicotine results in increased activity of TRPV1 protein
CTD PMID:19483072 PMID:26524655 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TSC22D1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TSC22D1 mRNA] CTD PMID:20230807 NCBI chr15:58,159,612...58,260,244
Ensembl chr15:51,749,510...51,850,958
JBrowse link
G Tshr thyroid stimulating hormone receptor increases expression ISO Nicotine results in increased expression of TSHR mRNA CTD PMID:18247414 NCBI chr 6:116,072,321...116,206,009
Ensembl chr 6:110,341,581...110,474,538
JBrowse link
G Tspo translocator protein multiple interactions ISO [Flumazenil binds to and results in decreased activity of TSPO protein] which results in decreased susceptibility to Nicotine CTD PMID:7862733 NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:114,720,188...114,730,450
JBrowse link
G Tuba4a tubulin, alpha 4A decreases expression ISO Nicotine results in decreased expression of TUBA4A mRNA CTD PMID:16949557 NCBI chr 9:84,158,871...84,174,041
Ensembl chr 9:76,709,614...76,713,918
JBrowse link
G Tubb4a tubulin, beta 4A class IVa decreases expression ISO Nicotine results in decreased expression of TUBB4A mRNA CTD PMID:21955143 NCBI chr 9:2,004,836...2,012,281
Ensembl chr 9:1,917,845...1,925,291
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO Nicotine results in decreased expression of TUBB mRNA CTD PMID:16949557 NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Tut4 terminal uridylyl transferase 4 increases expression ISO Nicotine results in increased expression of TUT4 mRNA CTD PMID:16949557 NCBI chr 5:128,354,975...128,535,288
Ensembl chr 5:123,203,003...123,306,465
JBrowse link
G Twf2 twinfilin actin-binding protein 2 decreases expression ISO Nicotine results in decreased expression of TWF2 mRNA CTD PMID:17997037 NCBI chr 8:115,723,980...115,737,025
Ensembl chr 8:106,845,253...106,858,298
JBrowse link
G Twist1 twist family bHLH transcription factor 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of TWIST1 mRNA
Nicotine promotes the reaction [Quartz results in increased expression of TWIST1 protein]; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of TWIST1 protein]
CTD PMID:23219715 PMID:36868510 NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Txn1 thioredoxin 1 increases expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of TXN1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased expression of TXN1 protein]; methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TXN1 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TXN1 protein]
CTD PMID:28082123 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txndc9 thioredoxin domain containing 9 increases expression ISO Nicotine results in increased expression of TXNDC9 mRNA CTD PMID:16949557 NCBI chr 9:47,707,628...47,717,761
Ensembl chr 9:40,211,412...40,384,279
Ensembl chr 9:40,211,412...40,384,279
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Nicotine results in increased expression of TXNIP mRNA CTD PMID:17456735 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G U2surp U2 snRNP-associated SURP domain containing increases expression ISO Nicotine results in increased expression of U2SURP mRNA CTD PMID:16949557 NCBI chr 8:104,898,580...104,963,642
Ensembl chr 8:96,022,957...96,075,691
JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of UBA2 protein
[Nicotine results in increased expression of UBA2 protein] which results in increased sumoylation of EEF2 protein
CTD PMID:21554491 NCBI chr 1:95,912,422...95,939,870
Ensembl chr 1:86,775,244...86,802,682
JBrowse link
G Ubb ubiquitin B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UBB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of UBB mRNA] CTD PMID:20230807 NCBI chr10:47,746,923...47,748,628
Ensembl chr10:47,245,637...47,249,333
JBrowse link
G Ubc ubiquitin C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UBC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UBC mRNA] CTD PMID:20230807 NCBI chr12:36,899,673...36,905,275
Ensembl chr12:31,239,152...31,243,925
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C increases expression
decreases expression
multiple interactions
ISO Nicotine results in increased expression of UBE2C mRNA
Nicotine results in decreased expression of UBE2C mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE2C mRNA]
CTD PMID:16949557 PMID:23825647 NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of UBE2D2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UBE2D2 mRNA] CTD PMID:20230807 NCBI chr18:27,638,399...27,680,386
Ensembl chr18:27,364,303...27,406,181
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I decreases expression ISO Nicotine results in decreased expression of UBE2I mRNA CTD PMID:18247414 NCBI chr10:14,782,245...14,802,911
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443
JBrowse link
G Ube3a ubiquitin protein ligase E3A multiple interactions
decreases expression
ISO Mecamylamine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA]; Nicotine inhibits the reaction [alpha-cobratoxin results in decreased expression of UBE3A mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA] CTD PMID:12588870 NCBI chr 1:119,204,244...119,297,097
Ensembl chr 1:110,070,480...110,157,250
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of UCHL1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UCHL1 mRNA] CTD PMID:20230807 NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,485,031...41,495,590
JBrowse link
G Ucp1 uncoupling protein 1 decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of UCP1 mRNA; Nicotine results in decreased expression of UCP1 protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 protein
CTD PMID:33091441 NCBI chr19:41,713,350...41,721,421
Ensembl chr19:24,808,783...24,816,852
JBrowse link
G Ufm1 ubiquitin-fold modifier 1 increases expression ISO Nicotine results in increased expression of UFM1 mRNA CTD PMID:16949557 NCBI chr 2:140,119,722...140,127,866
Ensembl chr 2:137,966,678...137,978,089
Ensembl chr 2:137,966,678...137,978,089
JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 increases expression ISO Nicotine results in increased expression of UGP2 mRNA CTD PMID:18247414 NCBI chr14:99,657,637...99,698,573
Ensembl chr14:95,456,330...95,496,830
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Nicotine CTD PMID:14570768 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation
decreases expression
ISO UGT1A4 protein results in increased glucuronidation of Nicotine
Nicotine results in decreased expression of UGT1A5 mRNA
CTD PMID:14570768 PMID:16141602 PMID:21955143 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Nicotine CTD PMID:14570768 PMID:16141602 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Unc119 unc-119 lipid binding chaperone decreases expression ISO Nicotine results in decreased expression of UNC119 mRNA CTD PMID:16949557 NCBI chr10:63,735,927...63,741,404
Ensembl chr10:63,237,903...63,243,339
JBrowse link
G Unc45b unc-45 myosin chaperone B decreases expression EXP Nicotine results in decreased expression of UNC45B mRNA CTD PMID:27782041 NCBI chr10:68,343,011...68,370,683
Ensembl chr10:67,845,462...67,873,389
JBrowse link
G Unc5b unc-5 netrin receptor B increases expression ISO Nicotine results in increased expression of UNC5B mRNA CTD PMID:23825647 NCBI chr20:29,240,639...29,307,270
Ensembl chr20:28,697,726...28,764,537
JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO Nicotine results in increased expression of UPP1 mRNA CTD PMID:23825647 NCBI chr14:88,023,155...88,043,036
Ensembl chr14:83,809,960...83,829,462
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 decreases expression EXP Nicotine results in decreased expression of UQCRC2 protein CTD PMID:28681937 NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:175,167,894...175,199,453
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 decreases expression ISO Nicotine results in decreased expression of UQCRFS1 mRNA CTD PMID:18247414 NCBI chr17:34,173,787...34,190,952
Ensembl chr17:33,977,921...33,982,479
JBrowse link
G Uri1 URI1, prefoldin-like chaperone increases expression ISO Nicotine results in increased expression of URI1 mRNA CTD PMID:17997037 NCBI chr 1:99,783,157...99,845,787
Ensembl chr 1:90,646,393...90,709,026
JBrowse link
G Uros uroporphyrinogen III synthase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UROS mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UROS mRNA] CTD PMID:20230807 NCBI chr 1:197,920,827...197,943,183
Ensembl chr 1:188,490,323...188,512,249
JBrowse link
G Vamp4 vesicle-associated membrane protein 4 increases expression ISO Nicotine results in increased expression of VAMP4 mRNA CTD PMID:17997037 NCBI chr13:77,453,135...77,475,909
Ensembl chr13:74,919,880...74,933,686
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Nicotine results in increased expression of VCAM1 mRNA CTD PMID:11166759 PMID:16254210 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vcan versican increases expression ISO Nicotine results in increased expression of VCAN mRNA CTD PMID:23825647 NCBI chr 2:22,497,035...22,595,955
Ensembl chr 2:20,761,718...20,860,637
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
decreases expression
increases secretion
affects response to substance
decreases secretion
ISO
EXP
Nicotine results in increased expression of VEGFA mRNA; Nicotine results in increased expression of VEGFA protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA
Nicotine results in decreased expression of VEGFA protein
Nicotine results in increased secretion of VEGFA protein
Nicotine affects the susceptibility to VEGFA
Nicotine results in decreased secretion of VEGFA protein
CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of VEGFA protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of VEGFA protein]
CTD PMID:14569062 PMID:16499655 PMID:20426880 PMID:20457658 PMID:21378373 More... NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin decreases expression
multiple interactions
increases expression
ISO Nicotine results in decreased expression of VIM mRNA
Nicotine promotes the reaction [Quartz results in increased expression of VIM protein]; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of VIM protein]
Nicotine results in increased expression of VIM mRNA; Nicotine results in increased expression of VIM protein
CTD PMID:18247414 PMID:18844224 PMID:23219715 PMID:36868510 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Vps28 VPS28 subunit of ESCRT-I multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of VPS28 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of VPS28 mRNA] CTD PMID:20230807 NCBI chr 7:110,222,638...110,226,486
Ensembl chr 7:108,341,989...108,345,837
JBrowse link
G Vps41 VPS41 subunit of HOPS complex multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of VPS41 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of VPS41 mRNA] CTD PMID:20230807 NCBI chr17:50,758,732...50,923,129
Ensembl chr17:46,063,124...46,227,791
JBrowse link
G Vrk2 VRK serine/threonine kinase 2 decreases expression ISO Nicotine results in decreased expression of VRK2 mRNA CTD PMID:23825647 NCBI chr14:104,514,815...104,635,549
Ensembl chr14:100,313,601...100,434,527
JBrowse link
G Vwf von Willebrand factor increases expression
decreases expression
ISO Nicotine results in increased expression of VWF mRNA
Nicotine results in decreased expression of VWF mRNA
CTD PMID:11166759 PMID:17456735 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:158,360,152...158,491,539
JBrowse link
G Wbp4 WW domain binding protein 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of WBP4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of WBP4 mRNA] CTD PMID:20230807 NCBI chr15:61,271,774...61,299,740
Ensembl chr15:54,862,843...54,890,647
JBrowse link
G Wnt4 Wnt family member 4 multiple interactions
increases expression
ISO Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of WNT4 mRNA]; Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of WNT4 protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of WNT4 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of WNT4 protein]
Nicotine results in increased expression of WNT4 mRNA; Nicotine results in increased expression of WNT4 protein
CTD PMID:33640489 PMID:35411647 NCBI chr 5:154,797,245...154,818,565
Ensembl chr 5:149,514,018...149,532,859
JBrowse link
G Wnt7b Wnt family member 7B increases expression ISO Nicotine results in increased expression of WNT7B mRNA CTD PMID:23825647 NCBI chr 7:118,514,684...118,559,316
Ensembl chr 7:116,634,814...116,679,581
JBrowse link
G Xaf1 XIAP associated factor 1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of XAF1 mRNA CTD PMID:37951547 NCBI chr10:57,415,935...57,428,348
Ensembl chr10:56,917,121...56,929,770
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP Nicotine inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA] CTD PMID:18477628 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Xdh xanthine dehydrogenase increases activity
multiple interactions
EXP Nicotine results in increased activity of XDH protein
Sodium Acetate inhibits the reaction [Nicotine results in increased activity of XDH protein]
CTD PMID:31857090 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
increases expression
ISO [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of XIAP protein; Curcumin inhibits the reaction [Nicotine results in increased expression of XIAP protein]; Hexamethonium affects the reaction [Nicotine results in increased expression of XIAP protein]
Nicotine results in increased expression of XIAP mRNA; Nicotine results in increased expression of XIAP protein
CTD PMID:16601104 PMID:18676776 PMID:20727180 PMID:21267677 PMID:30259641 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Xist X inactive specific transcript increases expression ISO Nicotine results in increased expression of XIST mRNA CTD PMID:16949557 NCBI chr  X:72,540,753...72,558,266 JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO XRCC1 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine] CTD PMID:29747151 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:80,141,207...80,168,701
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase increases expression ISO Nicotine results in increased expression of YES1 mRNA CTD PMID:16949557 NCBI chr 9:120,646,657...120,753,880
Ensembl chr 9:113,200,256...113,299,837
JBrowse link
G Yipf4 Yip1 domain family, member 4 decreases expression ISO Nicotine results in decreased expression of YIPF4 mRNA CTD PMID:17997037 NCBI chr 6:26,702,647...26,714,066
Ensembl chr 6:20,950,501...20,962,229
JBrowse link
G Zc3h7a zinc finger CCCH type containing 7 A increases splicing ISO Nicotine results in increased splicing of ZC3H7A mRNA alternative form CTD PMID:23825647 NCBI chr10:4,980,147...5,019,637
Ensembl chr10:4,473,203...4,512,665
JBrowse link
G Zcchc7 zinc finger CCHC-type containing 7 increases expression ISO Nicotine results in increased expression of ZCCHC7 mRNA CTD PMID:17997037 NCBI chr 5:63,787,292...63,968,960
Ensembl chr 5:58,993,290...59,173,300
JBrowse link
G Zcchc9 zinc finger CCHC-type containing 9 increases expression ISO Nicotine results in increased expression of ZCCHC9 mRNA CTD PMID:16949557 NCBI chr 2:24,773,319...24,783,339
Ensembl chr 2:23,038,317...23,048,217
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO Nicotine results in increased expression of ZEB1 mRNA CTD PMID:16949557 NCBI chr17:56,644,397...56,811,155
Ensembl chr17:51,948,948...52,115,214
JBrowse link
G Zfp146 zinc finger protein 146 increases expression ISO Nicotine results in increased expression of ZNF146 mRNA CTD PMID:16949557 NCBI chr 1:94,537,054...94,549,315
Ensembl chr 1:85,409,373...85,436,275
JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions
increases response to substance
increases expression
increases activity
ISO [Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA; [Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 protein; Bungarotoxins inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; methyllycaconitine inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; Nicotine promotes the reaction [STAT3 protein binds to ZFP36 promoter]; ZFP36 mRNA affects the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; ZFP36 mRNA affects the reaction [Nicotine results in increased degradation of TNF mRNA]
ZFP36 protein results in increased susceptibility to Nicotine
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA; HMOX1 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]; HMOX1 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; tin protoporphyrin IX inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of IL6 mRNA]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; ZFP36 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; zinc protoporphyrin inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; zinc protoporphyrin inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA]
Nicotine results in increased expression of ZFP36 mRNA; Nicotine results in increased expression of ZFP36 protein
Nicotine results in increased activity of ZFP36 promoter
CTD PMID:21606497 PMID:22093924 PMID:24095726 NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:83,669,084...83,671,564
JBrowse link
G Zfp42 zinc finger protein 42 increases expression
multiple interactions
ISO Nicotine results in increased expression of ZFP42 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of ZFP42 mRNA]
CTD PMID:15749260 NCBI chr16:55,568,903...55,577,883
Ensembl chr16:48,836,648...48,845,401
Ensembl chr 4:48,836,648...48,845,401
JBrowse link
G Zfp605 zinc finger protein 605 increases expression ISO Nicotine results in increased expression of ZNF605 mRNA CTD PMID:16949557 NCBI chr12:52,202,487...52,234,782
Ensembl chr12:46,545,073...46,575,828
JBrowse link
G Zfr zinc finger RNA binding protein multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA] CTD PMID:12588870 NCBI chr 2:62,864,333...62,927,377
Ensembl chr 2:61,137,611...61,200,322
JBrowse link
G Zic1 Zic family member 1 increases expression ISO Nicotine results in increased expression of ZIC1 mRNA CTD PMID:21955143 NCBI chr 8:100,785,282...100,797,716
Ensembl chr 8:91,908,576...91,912,731
JBrowse link
G Zmynd8 zinc finger, MYND-type containing 8 increases expression ISO Nicotine results in increased expression of ZMYND8 mRNA CTD PMID:16949557 NCBI chr 3:174,948,162...175,061,382
Ensembl chr 3:154,529,043...154,628,463
JBrowse link
G Znrf1 zinc and ring finger 1 decreases expression ISO Nicotine results in decreased expression of ZNRF1 mRNA CTD PMID:17997037 NCBI chr19:56,403,816...56,490,901
Ensembl chr19:39,496,527...39,580,969
JBrowse link
1,1-dimethyl-4-phenylpiperazinium iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions ISO
EXP
Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding competes with [Epibatidine binds to Chrna2 protein]
CTD
RGD
PMID:9454827 PMID:15016836 RGD:2303194 NCBI chr15:44,517,862...44,534,144
Ensembl chr15:40,342,317...40,358,601
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO
EXP
Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding [Epibatidine binds to Chrna3 protein]
CTD
RGD
PMID:9454827 PMID:15016836 RGD:2303194 NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO
EXP
Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding to Chrna4 protein; 1,1-dimethyl-4-phenylpiperazinium iodide competes with [Epibatidine binds to Chrna4 protein]
CTD
RGD
PMID:9454827 PMID:14645658 PMID:15016836 RGD:2303194 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
increases response to substance
increases activity
ISO Dimethylphenylpiperazinium Iodide inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]
CHRNA7 protein mutant form results in increased susceptibility to Dimethylphenylpiperazinium Iodide
Dimethylphenylpiperazinium Iodide results in increased activity of CHRNA7 protein
CTD PMID:10082212 PMID:10216184 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO
EXP
Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
1,1-dimethyl-4-phenylpiperazinium iodide affects binding to Chrnb2 protein; 1,1-dimethyl-4-phenylpiperazinium iodide competes with [Epibatidine binds to Chrnb2 protein]
CTD
RGD
PMID:14645658 PMID:15016836 RGD:2303194 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Dimethylphenylpiperazinium Iodide results in increased activity of [CHRNB4 protein binds to CHRNA4 protein] CTD PMID:9454827 NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Tnf tumor necrosis factor increases activity EXP TNF results in increased activity of Dimethylphenylpiperazinium Iodide CTD PMID:15086448 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
acetamiprid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases activity
multiple interactions
EXP acetamiprid results in increased activity of ACHE protein
Berberine inhibits the reaction [acetamiprid results in increased activity of ACHE protein]
CTD PMID:37350525 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Actrt2 actin-related protein T2 decreases expression EXP acetamiprid results in decreased expression of ACTRT2 mRNA CTD PMID:27782041 NCBI chr 5:170,518,470...170,519,870
Ensembl chr 5:165,236,086...165,237,629
JBrowse link
G Asap2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 increases expression EXP acetamiprid results in increased expression of ASAP2 mRNA CTD PMID:27782041 NCBI chr 6:46,386,605...46,549,669
Ensembl chr 6:40,657,880...40,820,975
JBrowse link
G B3gnt9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 increases expression EXP acetamiprid results in increased expression of B3GNT9 mRNA CTD PMID:27782041 NCBI chr19:50,039,649...50,042,206
Ensembl chr19:33,128,142...33,132,344
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP acetamiprid results in increased expression of BAX mRNA
Resveratrol inhibits the reaction [acetamiprid results in increased expression of BAX mRNA]
CTD PMID:39067744 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase increases activity EXP acetamiprid results in increased activity of BCHE protein CTD PMID:38011675 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
decreases expression
ISO
EXP
acetamiprid results in increased expression of BCL2 protein
Resveratrol inhibits the reaction [acetamiprid results in decreased expression of BCL2 mRNA]
CTD PMID:36457797 PMID:39067744 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases expression EXP acetamiprid results in increased expression of CACNA1H mRNA CTD PMID:27782041 NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Cacng1 calcium voltage-gated channel auxiliary subunit gamma 1 decreases expression EXP acetamiprid results in decreased expression of CACNG1 mRNA CTD PMID:27782041 NCBI chr10:93,152,558...93,165,246
Ensembl chr10:92,652,614...92,665,783
JBrowse link
G Card11 caspase recruitment domain family, member 11 increases expression EXP acetamiprid results in increased expression of CARD11 mRNA CTD PMID:27782041 NCBI chr12:18,735,088...18,872,045
Ensembl chr12:13,621,087...13,758,112
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
EXP acetamiprid results in increased expression of CASP3 mRNA; acetamiprid results in increased expression of CASP3 protein
Resveratrol inhibits the reaction [acetamiprid results in increased expression of CASP3 mRNA]; Resveratrol inhibits the reaction [acetamiprid results in increased expression of CASP3 protein]
CTD PMID:39067744 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases activity
multiple interactions
ISO
EXP
acetamiprid results in decreased activity of CAT protein
Berberine inhibits the reaction [acetamiprid results in decreased activity of CAT protein]
CTD PMID:31935421 PMID:37350525 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit decreases expression ISO acetamiprid results in decreased expression of CHRNA4 mRNA CTD PMID:30103633 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit decreases expression
increases activity
multiple interactions
ISO
EXP
acetamiprid results in decreased expression of CHRNA7 mRNA
acetamiprid results in increased activity of CHRNA7 protein; acetamiprid results in increased activity of CHRNA7 protein mutant form
Resveratrol inhibits the reaction [acetamiprid results in decreased expression of CHRNA7 mRNA]
CTD PMID:30103633 PMID:39067744 PMID:39393466 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit decreases expression
multiple interactions
ISO
EXP
acetamiprid results in decreased expression of CHRNB2
acetamiprid results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]; acetamiprid results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]
CTD PMID:16981889 PMID:25459289 PMID:27669271 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 decreases expression
multiple interactions
EXP acetamiprid results in decreased expression of COX4I1 mRNA
Berberine inhibits the reaction [acetamiprid results in decreased expression of COX4I1 mRNA]
CTD PMID:37350525 NCBI chr19:65,630,383...65,636,623
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
decreases expression
EXP
ISO
Vitamin E inhibits the reaction [acetamiprid results in decreased expression of CYP11A mRNA]; Vitamin E inhibits the reaction [acetamiprid results in decreased expression of CYP11A protein]
acetamiprid results in decreased expression of CYP11A1 mRNA
acetamiprid results in decreased expression of CYP11A1 mRNA; acetamiprid results in decreased expression of CYP11A1 protein
CTD PMID:28395332 PMID:30103633 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO acetamiprid results in decreased expression of CYP17A1 mRNA CTD PMID:30103633 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Dcdc2 doublecortin domain containing 2 increases expression
decreases expression
EXP acetamiprid results in increased expression of DCDC2 mRNA
acetamiprid results in decreased expression of DCDC2 mRNA
CTD PMID:27782041 NCBI chr17:40,274,009...40,459,757
Ensembl chr17:39,845,952...40,030,743
JBrowse link
G Des desmin decreases expression EXP acetamiprid results in decreased expression of DES mRNA CTD PMID:27782041 NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:76,850,982...76,858,699
JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 increases expression EXP acetamiprid results in increased expression of F2RL2 mRNA CTD PMID:27782041 NCBI chr 2:28,706,766...28,711,808
Ensembl chr 2:26,972,054...26,977,098
JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions
EXP acetamiprid results in increased expression of FASN protein
Folic Acid inhibits the reaction [acetamiprid results in increased expression of FASN protein]
CTD PMID:35124148 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
EXP acetamiprid results in increased activity of GPT protein
Folic Acid inhibits the reaction [acetamiprid results in increased activity of GPT protein]
CTD PMID:35124148 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression EXP acetamiprid results in decreased expression of GRIN1 mRNA CTD PMID:33523378 NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression EXP acetamiprid results in decreased expression of GRIN2A mRNA CTD PMID:33523378 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B decreases expression EXP acetamiprid results in decreased expression of GRIN2B mRNA CTD PMID:33523378 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 decreases expression ISO acetamiprid results in decreased expression of HSD17B1 mRNA CTD PMID:30103633 NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,009,728...86,011,927
JBrowse link
G Hspb7 heat shock protein family B (small) member 7 decreases expression EXP acetamiprid results in decreased expression of HSPB7 mRNA CTD PMID:27782041 NCBI chr 5:159,010,759...159,014,245
Ensembl chr 5:153,727,588...153,731,266
JBrowse link
G Iqcf1 IQ motif containing F1 decreases expression EXP acetamiprid results in decreased expression of IQCF1 mRNA CTD PMID:27782041 NCBI chr 8:107,129,462...107,133,242
Ensembl chr 8:107,130,704...107,133,249
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [acetamiprid results in increased expression of LHB protein] CTD PMID:28395332 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression ISO acetamiprid results in decreased expression of LHR mRNA CTD PMID:30103633 NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Lmod2 leiomodin 2 decreases expression EXP acetamiprid results in decreased expression of LMOD2 mRNA CTD PMID:27782041 NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases expression
EXP Resveratrol inhibits the reaction [acetamiprid results in decreased expression of MAPK3 mRNA] CTD PMID:39067744 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases expression
EXP Resveratrol inhibits the reaction [acetamiprid results in increased expression of MAPK8 mRNA] CTD PMID:39067744 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mb myoglobin decreases expression EXP acetamiprid results in decreased expression of MB mRNA CTD PMID:27782041 NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
G Mcmdc2 minichromosome maintenance domain containing 2 increases expression EXP acetamiprid results in increased expression of MCMDC2 mRNA CTD PMID:27782041 NCBI chr 5:14,071,609...14,120,435
Ensembl chr 5:9,298,101...9,338,300
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO acetamiprid results in decreased expression of MKI67 mRNA CTD PMID:30103633 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression
multiple interactions
EXP acetamiprid results in decreased expression of COX1 mRNA
Berberine inhibits the reaction [acetamiprid results in decreased expression of COX1 mRNA]
CTD PMID:37350525 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions
decreases expression
EXP Berberine inhibits the reaction [acetamiprid results in decreased expression of ND1 mRNA] CTD PMID:37350525 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 decreases expression
multiple interactions
EXP acetamiprid results in decreased expression of ND2 mRNA
Berberine inhibits the reaction [acetamiprid results in decreased expression of ND2 mRNA]
CTD PMID:37350525 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942
JBrowse link
G Myog myogenin decreases expression EXP acetamiprid results in decreased expression of MYOG mRNA CTD PMID:27782041 NCBI chr13:48,297,476...48,300,065
Ensembl chr13:45,745,436...45,748,039
JBrowse link
G Nags N-acetylglutamate synthase decreases expression EXP acetamiprid results in decreased expression of NAGS mRNA CTD PMID:27782041 NCBI chr10:87,598,516...87,602,650
Ensembl chr10:87,098,330...87,102,465
JBrowse link
G Napb NSF attachment protein beta increases expression EXP acetamiprid results in increased expression of NAPB mRNA CTD PMID:27782041 NCBI chr 3:136,132,248...136,179,280
Ensembl chr 3:136,133,428...136,179,345
JBrowse link
G Ndufaf2 NADH:ubiquinone oxidoreductase complex assembly factor 2 decreases expression EXP acetamiprid results in decreased expression of NDUFAF2 mRNA CTD PMID:27782041 NCBI chr 2:41,269,141...41,380,895
Ensembl chr 2:39,535,689...39,647,316
JBrowse link
G Or52s20 olfactory receptor family 52 subfamily S member 20 decreases expression EXP acetamiprid results in decreased expression of OR52S20 mRNA CTD PMID:27782041 NCBI chr 1:157,748,451...157,749,422
Ensembl chr 1:157,748,451...157,749,422
JBrowse link
G Or6d13b olfactory receptor family 6 subfamily D member 13B decreases expression EXP acetamiprid results in decreased expression of OR6D13B mRNA CTD PMID:27782041 NCBI chr 4:149,673,586...149,674,569
Ensembl chr 4:149,669,618...149,678,130
JBrowse link
G Phf21b PHD finger protein 21B increases expression EXP acetamiprid results in increased expression of PHF21B mRNA CTD PMID:27782041 NCBI chr 7:117,793,643...117,864,141
Ensembl chr 7:115,915,412...115,984,215
JBrowse link
G Plac8 placenta associated 8 increases expression EXP acetamiprid results in increased expression of PLAC8 mRNA CTD PMID:27782041 NCBI chr14:9,356,950...9,378,586
Ensembl chr14:9,063,048...9,074,264
JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases activity ISO acetamiprid results in increased activity of SLC22A1 protein CTD PMID:31364238 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO acetamiprid results in decreased activity of SLC22A2 protein CTD PMID:31364238 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity ISO acetamiprid results in decreased activity of SLC22A8 protein CTD PMID:31364238 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc45a3 solute carrier family 45, member 3 increases expression EXP acetamiprid results in increased expression of SLC45A3 mRNA CTD PMID:27782041 NCBI chr13:45,959,467...45,979,763
Ensembl chr13:43,407,293...43,427,588
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression EXP acetamiprid results in decreased expression of SLCO1B2 mRNA CTD PMID:27782041 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
multiple interactions
EXP acetamiprid results in decreased expression of SOD2 mRNA
Berberine inhibits the reaction [acetamiprid results in decreased expression of SOD2 mRNA]
CTD PMID:37350525 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
multiple interactions
EXP
ISO
acetamiprid results in decreased expression of STAR mRNA; acetamiprid results in decreased expression of STAR protein
Vitamin E inhibits the reaction [acetamiprid results in decreased expression of STAR mRNA]; Vitamin E inhibits the reaction [acetamiprid results in decreased expression of STAR protein]
CTD PMID:28395332 PMID:30103633 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Tada2b transcriptional adaptor 2B increases expression EXP acetamiprid results in increased expression of TADA2B mRNA CTD PMID:27782041 NCBI chr14:78,503,939...78,523,715
Ensembl chr14:74,279,217...74,290,755
JBrowse link
G Tnni2 troponin I2, fast skeletal type decreases expression EXP acetamiprid results in decreased expression of TNNI2 mRNA CTD PMID:27782041 NCBI chr 1:206,882,358...207,027,034
Ensembl chr 1:197,594,813...197,597,560
JBrowse link
G Tnni3 troponin I3, cardiac type increases expression
multiple interactions
EXP acetamiprid results in increased expression of TNNI3 protein
Resveratrol inhibits the reaction [acetamiprid results in increased expression of TNNI3 protein]
CTD PMID:39067744 NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression ISO acetamiprid results in decreased expression of TOP2A mRNA CTD PMID:30103633 NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tp53 tumor protein p53 increases expression ISO acetamiprid results in increased expression of TP53 protein CTD PMID:36457797 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Unc45b unc-45 myosin chaperone B decreases expression EXP acetamiprid results in decreased expression of UNC45B mRNA CTD PMID:27782041 NCBI chr10:68,343,011...68,370,683
Ensembl chr10:67,845,462...67,873,389
JBrowse link
carbachol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects binding
increases hydrolysis
multiple interactions
ISO Carbachol binds to ACHE protein
ACHE protein results in increased hydrolysis of Carbachol
Atropine inhibits the reaction [Carbachol results in increased metabolism of and results in increased secretion of ACHE protein]; Carbachol results in increased metabolism of and results in increased secretion of ACHE protein
CTD PMID:18602908 PMID:20493829 PMID:23047022 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Carbachol CTD PMID:12869393 NCBI chr11:78,976,861...79,123,343
Ensembl chr11:65,471,612...65,618,974
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP Carbachol increases phosphorylation of Akt1 protein in neuroepithelial stem cells RGD PMID:12676135 RGD:408346754 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Carbachol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; Carbachol inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; Carbachol inhibits the reaction [APP protein modified form results in increased expression of FOS protein]; Carbachol inhibits the reaction [APP protein modified form results in increased expression of TRP53 protein] CTD PMID:10758335 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp5 aquaporin 5 affects localization ISO Carbachol affects the localization of AQP5 protein CTD PMID:19443731 NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
JBrowse link
G Avpr1a arginine vasopressin receptor 1A multiple interactions EXP Carbachol promotes the reaction [[NC 1900 results in increased activity of AVPR1A protein] which results in increased abundance of Calcium]; Nicardipine inhibits the reaction [Carbachol promotes the reaction [[NC 1900 results in increased activity of AVPR1A protein] which results in increased abundance of Calcium]] CTD PMID:12646291 NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Carbachol inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; Carbachol inhibits the reaction [domoic acid results in increased localization of BAX protein] CTD PMID:10758335 PMID:19200344 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
ISO
EXP
Carbachol results in increased expression of BCL2 protein
Carbachol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]
CTD PMID:10758335 PMID:17708838 PMID:19200344 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression
multiple interactions
EXP Carbachol results in increased expression of BTG2 mRNA
Tetradecanoylphorbol Acetate inhibits the reaction [Carbachol results in increased expression of BTG2 mRNA]
CTD PMID:2005087 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO
EXP
Carbachol inhibits the reaction [domoic acid results in increased activity of CASP3 protein]
Carbachol results in decreased expression of CASP3 protein
CTD PMID:17708838 PMID:19200344 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cd40 CD40 molecule multiple interactions
increases expression
ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased expression of CD40 protein]; 4-diphenylacetoxy-1,1-dimethylpiperidinium inhibits the reaction [Carbachol results in increased expression of CD40 protein]; Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein]; Pirenzepine inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 increases activity
multiple interactions
affects binding
ISO Carbachol results in increased activity of CHRM1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; 1-oleoyl-2-acetylglycerol promotes the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; 2-aminoethoxydiphenyl borate inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; [Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; Atropine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Flufenamic Acid inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Gadolinium inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Lanthanum inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Pirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]; Thapsigargin inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
CHRM1 protein binds to Carbachol
[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium; [Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG mRNA; [Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG protein; brucine promotes the reaction [Carbachol binds to CHRM1 protein]
CTD PMID:8683117 PMID:9224827 PMID:11527950 PMID:18316702 NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions
affects binding
ISO eburnamonine promotes the reaction [Carbachol binds to CHRM2 protein]
Carbachol binds to and results in increased activity of CHRM2 protein; Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; otenzepad inhibits the reaction [Carbachol promotes the reaction [CHRM2 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]]
CHRM2 protein binds to Carbachol
CTD PMID:9224827 PMID:11181912 PMID:19002953 NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
increases response to substance
affects response to substance
affects binding
increases activity
ISO
EXP
Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein]; brucine promotes the reaction [Carbachol binds to CHRM3 protein]; brucine promotes the reaction [Carbachol results in increased activity of CHRM3 protein mutant form]; Carbachol binds to and results in increased activity of CHRM3 protein; Carbachol binds to and results in increased activity of CHRM3 protein mutant form; Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]; Guanylyl Imidodiphosphate inhibits the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]; Zinc Oxide promotes the reaction [Carbachol inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]]
[Metoclopramide binds to and results in decreased activity of CHRM3 protein] which results in decreased susceptibility to Carbachol
CHRM3 protein results in increased susceptibility to Carbachol
CHRM3 protein affects the susceptibility to Carbachol
CHRM3 protein binds to Carbachol
CTD PMID:9224827 PMID:14724830 PMID:15105209 PMID:19407017 PMID:20466821 More... NCBI chr17:64,696,549...65,158,622
Ensembl chr17:60,005,202...60,467,278
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions
affects binding
ISO brucine promotes the reaction [Carbachol binds to CHRM4 protein]
CHRM4 protein binds to Carbachol
CTD PMID:9224827 NCBI chr 3:98,349,080...98,356,821
Ensembl chr 3:77,893,425...77,901,159
JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP carbachol affects binding competes with [Epibatidine binds to Chrna2 protein] RGD PMID:15016836 RGD:2303194 NCBI chr15:44,517,862...44,534,144
Ensembl chr15:40,342,317...40,358,601
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit affects binding
multiple interactions
EXP Carbachol binds to [CHRNA3 protein binds to CHRNB4 protein]
Carbachol affects binding [Epibatidine binds to Chrna3 protein]
CTD
RGD
PMID:15615518 PMID:15016836 RGD:2303194 NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects binding
ISO
EXP
Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
carbachol affects binding to Chrna4 protein; carbachol competes with [Epibatidine binds to Chrna4 protein]
Carbachol binds to [CHRNA4 protein binds to CHRNB2 protein]
CTD
RGD
PMID:14645658 PMID:15615518 PMID:15016836 RGD:2303194 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
affects activity
ISO
EXP
1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Carbachol affects the activity of CHRNA7 protein]; Carbachol inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]; Carbachol inhibits the reaction [epibatidine binds to CHRNA7 protein]
Carbachol affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]
CTD PMID:10216184 PMID:19448648 PMID:21703337 PMID:29248576 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
affects binding
ISO
EXP
Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
carbachol affects binding to Chrnb2 protein; carbachol competes with [Epibatidine binds to Chrnb2 protein]
Carbachol binds to [CHRNA4 protein binds to CHRNB2 protein]
CTD
RGD
PMID:14645658 PMID:15615518 PMID:15016836 RGD:2303194 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit affects binding EXP Carbachol binds to [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:15615518 NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Creb1 cAMP responsive element binding protein 1 affects phosphorylation EXP Carbachol affects the phosphorylation of CREB1 protein CTD PMID:21295078 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases phosphorylation ISO carbachol decreases phosphorylation of EEF2 protein in colon cancer cells RGD PMID:31227218 RGD:153298919 NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:8,533,116...8,559,183
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
EXP Tetradecanoylphorbol Acetate inhibits the reaction [Carbachol results in increased expression of EGR1 mRNA] CTD PMID:2005087 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Faslg Fas ligand multiple interactions ISO [Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG mRNA; [Carbachol results in increased activity of CHRM1 protein] which results in increased expression of FASLG protein CTD PMID:8683117 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression
multiple interactions
EXP Carbachol results in increased expression of FGF1 protein
KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]]; Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]
CTD PMID:15264218 NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP
ISO
Carbachol results in increased expression of FOS protein
Carbachol inhibits the reaction [APP protein modified form results in increased expression of FOS protein]
CTD PMID:10404113 PMID:10758335 PMID:11074189 PMID:16023590 PMID:21295078 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gcg glucagon increases secretion
multiple interactions
ISO Carbachol results in increased secretion of GCG protein
NPY protein inhibits the reaction [Carbachol results in increased secretion of GCG protein]
CTD PMID:3329090 NCBI chr 3:67,522,489...67,531,533
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gna11 G protein subunit alpha 11 increases response to substance EXP GNA11 results in increased susceptibility to Carbachol CTD PMID:8014894 NCBI chr 7:8,814,285...8,828,628
Ensembl chr 7:8,162,750...8,179,812
JBrowse link
G Grm4 glutamate metabotropic receptor 4 multiple interactions ISO [Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium; Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]; Pertussis Toxin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; tertiapin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Tropicamide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr20:5,486,024...5,574,668
Ensembl chr20:5,481,124...5,572,821
JBrowse link
G Hdc histidine decarboxylase affects response to substance ISO HDC protein affects the susceptibility to Carbachol CTD PMID:12893847 NCBI chr 3:134,300,628...134,318,704
Ensembl chr 3:113,847,260...113,865,341
JBrowse link
G Il10 interleukin 10 affects expression ISO Carbachol affects the expression of IL10 mRNA CTD PMID:15698499 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta affects expression
increases expression
EXP Carbachol affects the expression of IL1B protein
Carbachol results in increased expression of IL1B protein
CTD PMID:16023590 PMID:21121909 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 increases expression ISO Carbachol results in increased expression of IL4 mRNA CTD PMID:15698499 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Ins1 insulin 1 multiple interactions
increases secretion
ISO
EXP
[Carbachol co-treated with Glucose] results in increased secretion of INS1 protein
Carbachol results in increased secretion of INS1 protein
Sirolimus inhibits the reaction [Carbachol results in increased secretion of INS1 protein]
CTD PMID:14578291 PMID:30761839 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects response to substance ISO KCNH2 protein mutant form affects the susceptibility to Carbachol CTD PMID:29574456 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO [Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium; Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]; Pertussis Toxin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Scopolamine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; tertiapin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]; Tropicamide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] CTD PMID:18171729 NCBI chr 3:60,353,990...60,518,110
Ensembl chr 3:39,945,351...40,109,124
JBrowse link
G Lyz2 lysozyme 2 affects secretion ISO Carbachol affects the secretion of LYZ protein CTD PMID:15234967 NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases activity
EXP
ISO
Calcium deficiency inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; calphostin C inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Carbachol results in decreased phosphorylation of MAPK1 protein
Carbachol results in increased activity of MAPK1 protein
CTD PMID:9121362 PMID:16877402 PMID:17008368 PMID:19002953 PMID:19017493 More... NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases activity
decreases phosphorylation
EXP
ISO
Calcium deficiency inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; calphostin C inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Ro 31-8220 inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Carbachol results in increased activity of MAPK3 protein
Carbachol results in decreased phosphorylation of MAPK3 protein
CTD PMID:9121362 PMID:16877402 PMID:17008368 PMID:19002953 PMID:19017493 More... NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Myl9 myosin light chain 9 increases phosphorylation EXP Carbachol results in increased phosphorylation of MYL9 protein CTD PMID:17272850 NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:145,281,937...145,288,333
JBrowse link
G Mylk myosin light chain kinase affects response to substance EXP MYLK protein affects the susceptibility to Carbachol CTD PMID:17272850 NCBI chr11:79,288,243...79,535,450
Ensembl chr11:65,783,008...66,030,261
JBrowse link
G Npy neuropeptide Y multiple interactions ISO NPY protein inhibits the reaction [Carbachol results in increased secretion of GCG protein] CTD PMID:3329090 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression
multiple interactions
EXP Carbachol results in increased expression of NR4A1 mRNA
Tetradecanoylphorbol Acetate inhibits the reaction [Carbachol results in increased expression of NR4A1 mRNA]
CTD PMID:2005087 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP PLCB1 protein inhibits the reaction [Carbachol results in increased abundance of Inositol Phosphates] CTD PMID:11377826 NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Prkcz protein kinase C, zeta multiple interactions
increases activity
ISO 1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PRKCZ protein]; Carbachol results in increased phosphorylation of and results in increased activity of PRKCZ protein
Carbachol results in increased activity of PRKCZ protein
CTD PMID:15255942 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression EXP Carbachol affects the expression of PTGS2 protein CTD PMID:16023590 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]; Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein; Egtazic Acid inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein]; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PTK2B protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein] CTD PMID:16877402 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO 1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Carbachol results in increased phosphorylation of and results in increased activity of RPS6KB1 protein CTD PMID:15255942 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Sct secretin decreases activity EXP SCT protein results in decreased activity of Carbachol CTD PMID:10198350 NCBI chr 1:205,812,435...205,813,246
Ensembl chr 1:196,382,856...196,383,658
JBrowse link
G Slc9a1 solute carrier family 9 member A1 increases activity ISO Carbachol results in increased activity of SLC9A1 protein CTD PMID:12842825 NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:145,576,334...145,629,624
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP Carbachol results in increased phosphorylation of and results in increased activity of SRC protein; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SRC protein affects the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PTK2B protein] CTD PMID:16877402 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tnf tumor necrosis factor increases expression
increases activity
decreases expression
multiple interactions
affects expression
EXP
ISO
Carbachol results in increased expression of TNF protein
TNF results in increased activity of Carbachol
Carbachol results in decreased expression of TNF mRNA
TNF protein inhibits the reaction [Carbachol results in increased abundance of Phosphatidic Acids]; TNF protein inhibits the reaction [Carbachol results in increased abundance of phosphatidylbutanol]
Carbachol affects the expression of TNF protein
CTD PMID:11245595 PMID:15086448 PMID:15698499 PMID:16023590 PMID:21121909 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Carbachol inhibits the reaction [APP protein modified form results in increased expression of TRP53 protein] CTD PMID:10758335 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 increases activity ISO Carbachol results in increased activity of TRPC1 protein CTD PMID:19289841 NCBI chr 8:105,142,931...105,193,842
Ensembl chr 8:96,263,329...96,314,276
JBrowse link
G Trpc2 transient receptor potential cation channel subfamily C member 2 increases activity ISO Carbachol results in increased activity of TRPC2 protein CTD PMID:19289841 NCBI chr 1:156,460,009...156,473,039
Ensembl chr 1:156,440,305...156,473,073
JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 multiple interactions
increases activity
ISO ethyl-1-(4-(2*3*3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate inhibits the reaction [Carbachol results in increased activity of TRPC3 protein] CTD PMID:19289841 NCBI chr 2:121,409,436...121,487,095
Ensembl chr 2:119,481,400...119,558,855
JBrowse link
G Trpc4 transient receptor potential cation channel, subfamily C, member 4 multiple interactions
increases activity
increases response to substance
ISO TRPC4 protein affects the reaction [Carbachol results in increased transport of Barium]; TRPC4 protein affects the reaction [Carbachol results in increased transport of Calcium]
Carbachol results in increased activity of TRPC4 protein
TRPC4 protein results in increased susceptibility to Carbachol
CTD PMID:11830588 PMID:19289841 PMID:29658714 NCBI chr 2:140,457,841...140,629,556
Ensembl chr 2:138,308,084...138,476,768
JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 multiple interactions ISO Carbachol promotes the reaction [TRPC5 protein results in increased transport of Calcium]; resveratrol inhibits the reaction [Carbachol promotes the reaction [TRPC5 protein results in increased transport of Calcium]] CTD PMID:21127073 NCBI chr  X:112,742,828...113,027,638
Ensembl chr  X:107,939,131...108,230,991
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions
increases activity
ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Carbachol results in increased activity of TRPC6 protein] CTD PMID:17603544 NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:5,758,935...5,828,092
JBrowse link
clothianidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca13 ATP binding cassette subfamily A member 13 increases expression ISO clothianidin results in increased expression of ABCA13 mRNA CTD PMID:31626844 NCBI chr14:83,873,397...84,376,138
Ensembl chr14:83,873,940...84,375,075
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 decreases expression ISO clothianidin results in decreased expression of ABCB6 mRNA CTD PMID:29044138 NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:76,668,554...76,676,924
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO clothianidin results in increased expression of ABCC1 mRNA CTD PMID:31626844 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression
EXP [enilconazole co-treated with clothianidin] results in increased expression of ABCC3 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of ABCC3 mRNA
clothianidin results in increased expression of ABCC3 mRNA
CTD PMID:33426623 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 decreases expression ISO clothianidin results in decreased expression of ABCD2 mRNA CTD PMID:31626844 NCBI chr 7:124,142,597...124,191,202
Ensembl chr 7:122,263,032...122,311,642
JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 decreases expression ISO clothianidin results in decreased expression of ABCD3 mRNA CTD PMID:31626844 NCBI chr 2:212,536,791...212,590,379
Ensembl chr 2:209,852,087...209,906,020
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO clothianidin results in decreased expression of ABCG1 mRNA CTD PMID:29044138 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B decreases expression ISO clothianidin results in decreased expression of ABHD4 mRNA CTD PMID:31626844 NCBI chr15:31,674,090...31,686,051
Ensembl chr15:27,704,113...27,716,966
JBrowse link
G Abi3bp ABI family member 3 binding protein decreases expression ISO clothianidin results in decreased expression of ABI3BP mRNA CTD PMID:31626844 NCBI chr11:57,381,282...57,597,989
Ensembl chr11:43,913,043...44,128,929
JBrowse link
G Ache acetylcholinesterase decreases expression ISO clothianidin results in decreased expression of ACHE mRNA CTD PMID:35264496 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Adcy2 adenylate cyclase 2 increases expression ISO clothianidin results in increased expression of ADCY2 mRNA CTD PMID:31626844 NCBI chr 1:36,204,054...36,650,645
Ensembl chr 1:34,375,895...34,822,236
JBrowse link
G Adcy4 adenylate cyclase 4 decreases expression ISO clothianidin results in decreased expression of ADCY4 mRNA CTD PMID:29044138 NCBI chr15:33,236,201...33,252,070
Ensembl chr15:29,266,287...29,282,108
JBrowse link
G Adgrb2 adhesion G protein-coupled receptor B2 decreases expression ISO clothianidin results in decreased expression of ADGRB2 mRNA CTD PMID:31626844 NCBI chr 5:147,581,573...147,646,726
Ensembl chr 5:142,331,329...142,362,540
JBrowse link
G Adgrf5 adhesion G protein-coupled receptor F5 decreases expression ISO clothianidin results in decreased expression of ADGRF5 mRNA CTD PMID:31626844 NCBI chr 9:25,014,861...25,128,045
Ensembl chr 9:17,520,009...17,623,968
JBrowse link
G Adgrg6 adhesion G protein-coupled receptor G6 decreases expression ISO clothianidin results in decreased expression of ADGRG6 mRNA CTD PMID:31626844 NCBI chr 1:10,633,004...10,774,685
Ensembl chr 1:8,812,904...8,954,123
JBrowse link
G Adrb2 adrenoceptor beta 2 decreases expression ISO clothianidin results in decreased expression of ADRB2 mRNA CTD PMID:31626844 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Agbl3 AGBL carboxypeptidase 3 increases expression ISO clothianidin results in increased expression of AGBL3 mRNA CTD PMID:31626844 NCBI chr 4:64,416,139...64,498,987
Ensembl chr 4:63,453,940...63,531,188
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 increases expression ISO clothianidin results in increased expression of AKR1B7 mRNA CTD PMID:33563863 NCBI chr 4:64,043,901...64,083,751
Ensembl chr 4:63,076,800...63,089,502
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression
multiple interactions
EXP clothianidin results in increased expression of ALDH1A1 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of ALDH1A1 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of ALDH1A1 mRNA
CTD PMID:33426623 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Amz1 archaelysin family metallopeptidase 1 increases expression ISO clothianidin results in increased expression of AMZ1 mRNA CTD PMID:31626844 NCBI chr12:13,886,518...13,924,275
Ensembl chr12:13,891,123...13,909,783
JBrowse link
G Ank3 ankyrin 3 decreases expression ISO clothianidin results in decreased expression of ANK3 mRNA CTD PMID:31626844 NCBI chr20:18,601,307...19,224,790
Ensembl chr20:18,602,786...19,086,300
JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression ISO clothianidin results in decreased expression of ANKRD37 mRNA CTD PMID:31626844 NCBI chr16:53,001,487...53,004,545
Ensembl chr16:46,268,443...46,271,963
JBrowse link
G Aplf aprataxin and PNKP like factor increases expression ISO clothianidin results in increased expression of APLF mRNA CTD PMID:31626844 NCBI chr 4:121,627,800...121,679,980
Ensembl chr 4:120,070,471...120,122,633
JBrowse link
G Arhgap17 Rho GTPase activating protein 17 increases expression ISO clothianidin results in increased expression of ARHGAP17 mRNA CTD PMID:31626844 NCBI chr 1:187,238,675...187,328,093
Ensembl chr 1:177,807,583...177,896,854
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 increases expression ISO clothianidin results in increased expression of ARHGEF2 mRNA CTD PMID:31626844 NCBI chr 2:176,358,909...176,416,178
Ensembl chr 2:174,062,976...174,118,355
JBrowse link
G Arl11 ARF like GTPase 11 increases expression ISO clothianidin results in increased expression of ARL11 mRNA CTD PMID:31626844 NCBI chr15:35,483,330...35,485,579
Ensembl chr15:35,480,018...35,496,596
JBrowse link
G Arl14 ARF like GTPase 14 increases expression ISO clothianidin results in increased expression of ARL14 mRNA CTD PMID:35690182 NCBI chr 2:155,778,826...155,780,065
Ensembl chr 2:153,468,977...153,469,555
JBrowse link
G Arl6 ARF like GTPase 6 increases expression ISO clothianidin results in increased expression of ARL6 mRNA CTD PMID:31626844 NCBI chr11:54,180,271...54,207,136
Ensembl chr11:40,712,022...40,737,937
JBrowse link
G Asb11 ankyrin repeat and SOCS box containing 11 increases expression ISO clothianidin results in increased expression of ASB11 mRNA CTD PMID:31626844 NCBI chr  X:30,014,485...30,037,808
Ensembl chr  X:29,992,416...30,037,807
JBrowse link
G Asphd1 aspartate beta-hydroxylase domain containing 1 decreases expression ISO clothianidin results in decreased expression of ASPHD1 mRNA CTD PMID:31626844 NCBI chr 1:181,552,968...181,556,902
Ensembl chr 1:181,552,884...181,556,090
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression ISO clothianidin results in decreased expression of ATP1A2 mRNA CTD PMID:29044138 NCBI chr13:87,261,964...87,286,911
Ensembl chr13:84,729,601...84,754,544
JBrowse link
G Atp23 ATP23 metallopeptidase and ATP synthase assembly factor homolog increases expression ISO clothianidin results in increased expression of XRCC6BP1 mRNA CTD PMID:31626844 NCBI chr 7:62,714,752...62,729,893
Ensembl chr 7:62,714,785...62,729,862
JBrowse link
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 decreases expression ISO clothianidin results in decreased expression of ATP2B3 mRNA CTD PMID:29044138 NCBI chr  X:156,367,582...156,464,085
Ensembl chr  X:151,216,507...151,286,775
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 increases expression ISO clothianidin results in increased expression of ATP6V0D2 mRNA CTD PMID:31626844 NCBI chr 5:38,133,151...38,182,245
Ensembl chr 5:33,336,264...33,385,354
JBrowse link
G Awat1 acyl-CoA wax alcohol acyltransferase 1 increases expression ISO clothianidin results in increased expression of AWAT1 mRNA CTD PMID:31626844 NCBI chr  X:65,668,205...65,674,450
Ensembl chr  X:65,668,205...65,674,450
JBrowse link
G Axin1 axin 1 decreases expression ISO clothianidin results in decreased expression of AXIN1 mRNA CTD PMID:31626844 NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,163,684...15,215,615
JBrowse link
G Azin2 antizyme inhibitor 2 decreases expression ISO clothianidin results in decreased expression of AZIN2 mRNA CTD PMID:29044138 NCBI chr 5:141,281,310...141,310,415
Ensembl chr 5:141,281,249...141,310,397
JBrowse link
G Barhl1 BarH-like homeobox 1 increases expression ISO clothianidin results in increased expression of BARHL1 mRNA CTD PMID:31626844 NCBI chr 3:32,639,283...32,646,605
Ensembl chr 3:12,241,327...12,248,649
JBrowse link
G Bcr BCR activator of RhoGEF and GTPase decreases expression ISO clothianidin results in decreased expression of BCR mRNA CTD PMID:31626844 NCBI chr20:13,468,732...13,596,333
Ensembl chr20:13,471,668...13,597,016
JBrowse link
G Bicd2 BICD cargo adaptor 2 decreases expression ISO clothianidin results in decreased expression of BICD2 mRNA CTD PMID:31626844 NCBI chr17:15,259,773...15,304,889
Ensembl chr17:15,259,773...15,304,889
JBrowse link
G Bricd5 BRICHOS domain containing 5 decreases expression ISO clothianidin results in decreased expression of BRICD5 mRNA CTD PMID:29044138 NCBI chr10:14,003,276...14,004,809
Ensembl chr10:13,498,381...13,500,259
JBrowse link
G C11h21orf140 similar to human chromosome 21 open reading frame 140 increases expression ISO clothianidin results in increased expression of C21ORF140 mRNA CTD PMID:31626844 NCBI chr11:31,549,689...31,552,257
Ensembl chr11:31,544,426...31,552,290
JBrowse link
G C14h22orf31 similar to human chromosome 22 open reading frame 31 decreases expression ISO clothianidin results in decreased expression of C22ORF31 mRNA CTD PMID:31626844 NCBI chr14:84,373,414...84,374,948 JBrowse link
G C14h4orf36 similar to human chromosome 4 open reading frame 36 decreases expression ISO clothianidin results in decreased expression of C4ORF36 mRNA CTD PMID:31626844 NCBI chr14:6,058,581...6,065,848
Ensembl chr14:6,058,581...6,065,847
JBrowse link
G C18h5orf46 similar to human chromosome 5 open reading frame 46 increases expression ISO clothianidin results in increased expression of C5ORF46 mRNA CTD PMID:31626844 NCBI chr18:35,948,402...35,969,502
Ensembl chr18:35,948,402...35,969,502
JBrowse link
G C19h16orf74 similar to human chromosome 16 open reading frame 74 decreases expression ISO clothianidin results in decreased expression of C16ORF74 mRNA CTD PMID:31626844 NCBI chr19:65,568,997...65,594,994
Ensembl chr19:48,660,288...48,686,349
JBrowse link
G C20h21orf58 similar to human chromosome 21 open reading frame 58 decreases expression ISO clothianidin results in decreased expression of C21ORF58 mRNA CTD PMID:31626844 NCBI chr20:12,167,279...12,188,665
Ensembl chr20:12,175,442...12,187,017
JBrowse link
G C2cd4b C2 calcium-dependent domain containing 4B increases expression ISO clothianidin results in increased expression of C2CD4B mRNA CTD PMID:31626844 NCBI chr 8:68,372,793...68,396,477
Ensembl chr 8:68,384,847...68,396,328
JBrowse link
G C2h5orf34 similar to human chromosome 5 open reading frame 34 increases expression ISO clothianidin results in increased expression of C5ORF34 mRNA CTD PMID:29044138 NCBI chr 2:51,553,223...51,577,090
Ensembl chr 2:51,555,432...51,577,085
JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 decreases expression ISO clothianidin results in decreased expression of CACNB2 mRNA CTD PMID:31626844 NCBI chr17:82,473,097...82,818,564
Ensembl chr17:77,564,460...77,909,106
JBrowse link
G Calhm3 calcium homeostasis modulator 3 increases expression ISO clothianidin results in increased expression of CALHM3 mRNA CTD PMID:31626844 NCBI chr 1:255,984,593...255,989,594
Ensembl chr 1:246,043,258...246,048,259
JBrowse link
G Capn5 calpain 5 increases expression ISO clothianidin results in increased expression of CAPN5 mRNA CTD PMID:29044138 NCBI chr 1:161,827,474...161,884,142
Ensembl chr 1:152,416,252...152,472,923
JBrowse link
G Caps calcyphosine decreases expression ISO clothianidin results in decreased expression of CAPS mRNA CTD PMID:29044138 NCBI chr 9:1,630,871...1,632,758
Ensembl chr 9:1,544,719...1,545,647
JBrowse link
G Car3 carbonic anhydrase 3 increases expression ISO clothianidin results in increased expression of CA3 mRNA CTD PMID:31626844 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Carmil1 capping protein regulator and myosin 1 linker 1 decreases expression ISO clothianidin results in decreased expression of CARMIL1 mRNA CTD PMID:31626844 NCBI chr17:41,235,819...41,516,204
Ensembl chr17:40,808,389...41,088,326
JBrowse link
G Carmil3 capping protein regulator and myosin 1 linker 3 increases expression ISO clothianidin results in increased expression of CARMIL3 mRNA CTD PMID:29044138 NCBI chr15:32,948,228...32,965,829
Ensembl chr15:28,979,007...28,996,225
JBrowse link
G Ccdc17 coiled-coil domain containing 17 decreases expression ISO clothianidin results in decreased expression of CCDC17 mRNA CTD PMID:29044138 NCBI chr 5:135,288,799...135,293,339
Ensembl chr 5:130,045,938...130,056,673
JBrowse link
G Ccdc8 coiled-coil domain containing 8 increases expression ISO clothianidin results in increased expression of CCDC8 mRNA CTD PMID:31626844 NCBI chr 1:77,679,521...77,682,849
Ensembl chr 1:77,679,218...77,683,090
JBrowse link
G Ccser1 coiled-coil serine-rich protein 1 decreases expression ISO clothianidin results in decreased expression of CCSER1 mRNA CTD PMID:31626844 NCBI chr 4:91,483,896...92,720,439
Ensembl chr 4:90,292,780...91,388,786
JBrowse link
G Cd226 CD226 molecule decreases expression ISO clothianidin results in decreased expression of CD226 mRNA CTD PMID:31626844 NCBI chr18:84,723,330...84,819,836
Ensembl chr18:82,450,568...82,543,051
JBrowse link
G Cd34 CD34 molecule increases expression ISO clothianidin results in increased expression of CD34 mRNA CTD PMID:31626844 NCBI chr13:109,008,786...109,029,317
Ensembl chr13:106,480,043...106,499,832
JBrowse link
G Cd74 CD74 molecule increases expression ISO clothianidin results in increased expression of CD74 mRNA CTD PMID:31626844 NCBI chr18:56,527,071...56,536,406
Ensembl chr18:54,256,778...54,266,003
JBrowse link
G Cd8b CD8 subunit beta increases expression ISO clothianidin results in increased expression of CD8B mRNA CTD PMID:31626844 NCBI chr 4:104,870,911...104,886,838
Ensembl chr 4:103,312,578...103,328,553
JBrowse link
G Cdh8 cadherin 8 decreases expression ISO clothianidin results in decreased expression of CDH8 mRNA CTD PMID:31626844 NCBI chr19:5,494,552...5,901,950
Ensembl chr19:5,494,174...5,895,669
JBrowse link
G Cdrt15l2 CMT1A duplicated region transcript 15 like 2 increases expression ISO clothianidin results in increased expression of CDRT15L2 mRNA CTD PMID:31626844 NCBI chr16:11,226,012...11,231,967
Ensembl chr16:11,122,718...11,158,623
JBrowse link
G Ceacam6 CEA cell adhesion molecule 6 increases expression ISO clothianidin results in increased expression of CEACAM6 mRNA CTD PMID:31626844 NCBI chr 1:89,544,415...89,562,552
Ensembl chr 1:80,416,531...80,434,668
JBrowse link
G Cemip cell migration inducing hyaluronidase 1 increases expression ISO clothianidin results in increased expression of CEMIP mRNA CTD PMID:31626844 NCBI chr 1:147,316,052...147,471,552
Ensembl chr 1:137,908,920...138,062,415
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions ISO [clothianidin co-treated with thiacloprid] results in increased expression of CES2 protein CTD PMID:32201337 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cfap107 cilia and flagella associated protein 107 decreases expression ISO clothianidin results in decreased expression of CFAP107 mRNA CTD PMID:31626844 NCBI chr 5:156,212,385...156,231,481
Ensembl chr 5:156,212,385...156,231,481
JBrowse link
G Chat choline O-acetyltransferase decreases expression ISO clothianidin results in decreased expression of CHAT mRNA CTD PMID:35264496 NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO clothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:21538459 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit decreases expression
increases activity
ISO clothianidin results in decreased expression of CHRNA7 mRNA
clothianidin results in increased activity of CHRNA7 protein; clothianidin results in increased activity of CHRNA7 protein mutant form
CTD PMID:35264496 PMID:39393466 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP
ISO
clothianidin results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]; clothianidin results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]
clothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:16981889 PMID:21538459 PMID:25459289 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chst3 carbohydrate sulfotransferase 3 increases expression ISO clothianidin results in increased expression of CHST3 mRNA CTD PMID:29044138 NCBI chr20:28,114,386...28,152,046
Ensembl chr20:28,114,404...28,121,807
JBrowse link
G Cldn14 claudin 14 decreases expression ISO clothianidin results in decreased expression of CLDN14 mRNA CTD PMID:35690182 NCBI chr11:46,701,940...46,799,049
Ensembl chr11:33,232,220...33,329,171
JBrowse link
G Clec3b C-type lectin domain family 3, member B increases expression ISO clothianidin results in increased expression of CLEC3B mRNA CTD PMID:31626844 NCBI chr 8:122,810,120...122,815,837
Ensembl chr 8:122,810,149...122,815,835
JBrowse link
G Cmtm5 CKLF-like MARVEL transmembrane domain containing 5 increases expression ISO clothianidin results in increased expression of CMTM5 mRNA CTD PMID:31626844 NCBI chr15:32,382,171...32,385,288
Ensembl chr15:28,412,624...28,415,287
JBrowse link
G Cntnap1 contactin associated protein 1 decreases expression ISO clothianidin results in decreased expression of CNTNAP1 mRNA CTD PMID:31626844 NCBI chr10:86,109,850...86,125,612
Ensembl chr10:86,111,643...86,125,611
JBrowse link
G Col12a1 collagen type XII alpha 1 chain decreases expression ISO clothianidin results in decreased expression of COL12A1 mRNA CTD PMID:31626844 NCBI chr 8:89,427,834...89,545,886
Ensembl chr 8:80,547,593...80,665,686
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO clothianidin results in decreased expression of COL1A1 mRNA CTD PMID:29044138 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col5a2 collagen type V alpha 2 chain decreases expression ISO clothianidin results in decreased expression of COL5A2 mRNA CTD PMID:35690182 NCBI chr 9:54,940,768...55,090,151
Ensembl chr 9:47,448,736...47,598,154
JBrowse link
G Col6a2 collagen type VI alpha 2 chain increases expression ISO clothianidin results in increased expression of COL6A2 mRNA CTD PMID:31626844 NCBI chr20:12,021,182...12,048,932
Ensembl chr20:12,021,767...12,057,564
JBrowse link
G Col7a1 collagen type VII alpha 1 chain decreases expression ISO clothianidin results in decreased expression of COL7A1 mRNA CTD PMID:29044138 NCBI chr 8:118,483,364...118,515,736
Ensembl chr 8:109,604,861...109,637,252
JBrowse link
G Coro2b coronin 2B decreases expression ISO clothianidin results in decreased expression of CORO2B mRNA CTD PMID:31626844 NCBI chr 8:62,906,861...63,017,295
Ensembl chr 8:62,906,867...63,017,302
JBrowse link
G Cpeb3 cytoplasmic polyadenylation element binding protein 3 decreases expression ISO clothianidin results in decreased expression of CPEB3 mRNA CTD PMID:31626844 NCBI chr 1:244,161,690...244,343,765
Ensembl chr 1:234,751,733...234,931,560
JBrowse link
G Cpne4 copine 4 increases expression ISO clothianidin results in increased expression of CPNE4 mRNA CTD PMID:31626844 NCBI chr 8:114,056,152...114,531,855
Ensembl chr 8:105,177,376...105,653,068
JBrowse link
G Csmd1 CUB and Sushi multiple domains 1 increases expression ISO clothianidin results in increased expression of CSMD1 mRNA CTD PMID:31626844 NCBI chr16:78,920,549...80,520,710
Ensembl chr16:72,218,503...73,817,614
JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule increases expression ISO clothianidin results in increased expression of CXADR mRNA CTD PMID:29044138 NCBI chr11:30,469,778...30,516,990
Ensembl chr11:16,982,860...17,030,046
JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression ISO clothianidin results in decreased expression of CYBA mRNA CTD PMID:35690182 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 affects expression ISO clothianidin affects the expression of CYP19A1 mRNA CTD PMID:33563863 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO [clothianidin co-treated with enilconazole] results in increased expression of CYP1A2 mRNA; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP1A2 mRNA
clothianidin results in increased expression of CYP1A2 mRNA
CTD PMID:32201337 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [clothianidin co-treated with enilconazole] results in increased expression of CYP1B1 protein CTD PMID:32201337 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression
multiple interactions
EXP clothianidin results in increased expression of CYP2B2 mRNA
[enilconazole co-treated with clothianidin] results in increased expression of CYP2B2 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of CYP2B2 mRNA
CTD PMID:33426623 NCBI chr 1:90,722,243...90,736,272
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [clothianidin co-treated with thiacloprid] results in increased expression of CYP2B6 protein CTD PMID:32201337 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions
ISO clothianidin results in decreased expression of CYP2E1 mRNA
[clothianidin co-treated with enilconazole] results in decreased expression of CYP2E1 mRNA; [clothianidin co-treated with thiacloprid] results in increased expression of CYP2E1 protein; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA
CTD PMID:32201337 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO clothianidin results in increased expression of CYP3A4 mRNA
[clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 mRNA; [clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 protein; [clothianidin co-treated with thiacloprid] results in increased expression of CYP3A4 protein; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP3A4 mRNA
CTD PMID:32201337 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
increases expression
EXP [enilconazole co-treated with clothianidin] results in increased expression of CYP3A23-3A1 mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of CYP3A23-3A1 mRNA
clothianidin results in increased expression of CYP3A23-3A1 mRNA
CTD PMID:33426623 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
increases expression
ISO [clothianidin co-treated with enilconazole] results in increased expression of CYP3A5 protein; [thiacloprid co-treated with clothianidin] results in increased expression of CYP3A5 mRNA
clothianidin results in increased expression of CYP3A5 mRNA
CTD PMID:32201337 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
decreases expression
EXP [enilconazole co-treated with clothianidin] results in decreased expression of CYP7A1 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of CYP7A1 mRNA
clothianidin results in decreased expression of CYP7A1 mRNA
CTD PMID:33426623 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyth4 cytohesin 4 increases expression ISO clothianidin results in increased expression of CYTH4 mRNA CTD PMID:31626844 NCBI chr 7:112,032,711...112,057,204
Ensembl chr 7:110,152,272...110,176,741
JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 decreases expression ISO clothianidin results in decreased expression of DACT1 mRNA CTD PMID:31626844 NCBI chr 6:95,526,645...95,538,625
Ensembl chr 6:89,790,644...89,817,906
JBrowse link
G Defa5 defensin alpha 5 decreases expression ISO clothianidin results in decreased expression of DEFA5 mRNA CTD PMID:31626844 NCBI chr16:77,044,994...77,047,318
Ensembl chr16:70,342,530...70,344,836
JBrowse link
G Des desmin increases expression ISO clothianidin results in increased expression of DES mRNA CTD PMID:31626844 NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:76,850,982...76,858,699
JBrowse link
G Dgkd diacylglycerol kinase, delta increases expression ISO clothianidin results in increased expression of DGKD mRNA CTD PMID:31626844 NCBI chr 9:88,516,686...88,607,349
Ensembl chr 9:88,516,715...88,607,345
JBrowse link
G Dio3 iodothyronine deiodinase 3 increases expression ISO clothianidin results in increased expression of DIO3 mRNA CTD PMID:31626844 NCBI chr 6:135,107,072...135,108,933
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Dll3 delta like canonical Notch ligand 3 decreases expression ISO clothianidin results in decreased expression of DLL3 mRNA CTD PMID:31626844 NCBI chr 1:83,562,011...83,570,008
Ensembl chr 1:83,562,014...83,569,750
JBrowse link
G Dnai7 dynein axonemal intermediate chain 7 decreases expression ISO clothianidin results in decreased expression of DNAI7 mRNA CTD PMID:31626844 NCBI chr 4:179,874,338...179,910,716
Ensembl chr 4:178,143,500...178,179,980
JBrowse link
G Dnajc21 DnaJ heat shock protein family (Hsp40) member C21 increases expression ISO clothianidin results in increased expression of DNAJC21 mRNA CTD PMID:31626844 NCBI chr 2:59,419,507...59,446,746
Ensembl chr 2:59,419,510...59,446,752
JBrowse link
G Dnajc28 DnaJ heat shock protein family (Hsp40) member C28 decreases expression ISO clothianidin results in decreased expression of DNAJC28 mRNA CTD PMID:31626844 NCBI chr11:30,855,566...30,858,386
Ensembl chr11:30,853,526...30,858,441
JBrowse link
G Dnajc5g DnaJ heat shock protein family (Hsp40) member C5 gamma increases expression ISO clothianidin results in increased expression of DNAJC5G mRNA CTD PMID:31626844 NCBI chr 6:30,980,051...30,984,218
Ensembl chr 6:25,260,088...25,264,152
JBrowse link
G Dnase1l2 deoxyribonuclease 1 like 2 decreases expression ISO clothianidin results in decreased expression of DNASE1L2 mRNA CTD PMID:29044138 NCBI chr10:13,976,012...13,978,574
Ensembl chr10:13,471,479...13,473,763
JBrowse link
G Dnhd1 dynein heavy chain domain 1 decreases expression ISO clothianidin results in decreased expression of DNHD1 mRNA CTD PMID:29044138 NCBI chr 1:159,990,785...160,077,990
Ensembl chr 1:159,990,438...160,074,858
JBrowse link
G Dok5 docking protein 5 decreases expression ISO clothianidin results in decreased expression of DOK5 mRNA CTD PMID:31626844 NCBI chr 3:179,934,419...180,071,334
Ensembl chr 3:159,515,893...159,652,810
JBrowse link
G Dus3l dihydrouridine synthase 3-like increases expression ISO clothianidin results in increased expression of DUS3L mRNA CTD PMID:31626844 NCBI chr 9:1,680,619...1,685,784
Ensembl chr 9:1,594,123...1,598,655
JBrowse link
G Dusp15 dual specificity phosphatase 15 increases expression ISO clothianidin results in increased expression of DUSP15 mRNA CTD PMID:29044138 NCBI chr 3:161,868,746...161,880,432
Ensembl chr 3:141,408,498...141,418,999
JBrowse link
G Dusp16 dual specificity phosphatase 16 decreases expression ISO clothianidin results in decreased expression of DUSP16 mRNA CTD PMID:31626844 NCBI chr 4:169,278,118...169,361,508
Ensembl chr 4:167,548,155...167,629,980
JBrowse link
G Eaf2 ELL associated factor 2 decreases expression ISO clothianidin results in decreased expression of EAF2 mRNA CTD PMID:31626844 NCBI chr11:77,465,585...77,509,993
Ensembl chr11:63,960,200...64,004,610
JBrowse link
G Ece2 endothelin-converting enzyme 2 increases expression ISO clothianidin results in increased expression of ECE2 mRNA CTD PMID:31626844 NCBI chr11:93,767,559...93,782,896
Ensembl chr11:80,263,162...80,278,428
JBrowse link
G Efcab12 EF-hand calcium binding domain 12 decreases expression ISO clothianidin results in decreased expression of EFCAB12 mRNA CTD PMID:29044138 NCBI chr 4:148,869,381...148,892,922
Ensembl chr 4:148,869,387...148,890,560
JBrowse link
G Efs embryonal Fyn-associated substrate decreases expression ISO clothianidin results in decreased expression of EFS mRNA CTD PMID:31626844 NCBI chr15:32,362,401...32,374,490
Ensembl chr15:28,392,187...28,401,902
JBrowse link
G Eif3f eukaryotic translation initiation factor 3, subunit F decreases expression ISO clothianidin results in decreased expression of EIF3F mRNA CTD PMID:31626844 NCBI chr 1:162,934,220...162,943,204
Ensembl chr 1:162,934,212...162,943,204
JBrowse link
G Elf1 E74 like ETS transcription factor 1 increases expression ISO clothianidin results in increased expression of ELF1 mRNA CTD PMID:31626844 NCBI chr15:61,354,026...61,395,762
Ensembl chr15:54,865,616...54,986,699
JBrowse link
G Elmod1 ELMO domain containing 1 decreases expression ISO clothianidin results in decreased expression of ELMOD1 mRNA CTD PMID:31626844 NCBI chr 8:63,194,539...63,251,526
Ensembl chr 8:54,298,363...54,355,140
JBrowse link
G Eln elastin multiple interactions
decreases expression
EXP [enilconazole co-treated with clothianidin] results in decreased expression of ELN mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of ELN mRNA
clothianidin results in decreased expression of ELN mRNA
CTD PMID:33426623 NCBI chr12:27,604,983...27,648,413
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Enox1 ecto-NOX disulfide-thiol exchanger 1 increases expression ISO clothianidin results in increased expression of ENOX1 mRNA CTD PMID:35690182 NCBI chr15:58,924,519...59,488,919
Ensembl chr15:52,515,178...53,079,749
JBrowse link
G Enpp4 ectonucleotide pyrophosphatase/phosphodiesterase 4 increases expression ISO clothianidin results in increased expression of ENPP4 mRNA CTD PMID:29044138 NCBI chr 9:24,386,351...24,396,248
Ensembl chr 9:16,887,739...16,898,860
JBrowse link
G Epdr1 ependymin related 1 increases expression ISO clothianidin results in increased expression of EPDR1 mRNA CTD PMID:29044138 NCBI chr17:50,029,591...50,054,254
Ensembl chr17:45,333,956...45,358,594
JBrowse link
G Epn3 epsin 3 decreases expression ISO clothianidin results in decreased expression of EPN3 mRNA CTD PMID:31626844 NCBI chr10:79,438,978...79,449,516
Ensembl chr10:79,438,978...79,447,356
JBrowse link
G Eps8 EGFR pathway substrate 8, signaling adaptor increases expression ISO clothianidin results in increased expression of EPS8 mRNA CTD PMID:29044138 NCBI chr 4:172,119,497...172,291,670
Ensembl chr 4:170,388,378...170,486,873
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 increases expression ISO clothianidin results in increased expression of ERBB3 mRNA CTD PMID:31626844 NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Ergic1 endoplasmic reticulum-golgi intermediate compartment 1 increases expression ISO clothianidin results in increased expression of ERGIC1 mRNA CTD PMID:31626844 NCBI chr10:17,035,615...17,131,411
Ensembl chr10:16,531,194...16,626,957
JBrowse link
G Exoc4 exocyst complex component 4 decreases expression ISO clothianidin results in decreased expression of EXOC4 mRNA CTD PMID:31626844 NCBI chr 4:62,774,896...63,551,541
Ensembl chr 4:61,807,761...62,585,723
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases expression ISO clothianidin results in decreased expression of EZH2 mRNA CTD PMID:31626844 NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
G F2 coagulation factor II, thrombin decreases expression ISO clothianidin results in decreased expression of F2 mRNA CTD PMID:31626844 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Fam110c family with sequence similarity 110, member C increases expression ISO clothianidin results in increased expression of FAM110C mRNA CTD PMID:31626844 NCBI chr 6:47,638,466...47,644,723
Ensembl chr 6:47,638,276...47,644,634
JBrowse link
G Fam131a family with sequence similarity 131, member A decreases expression ISO clothianidin results in decreased expression of FAM131A mRNA CTD PMID:31626844 NCBI chr11:93,715,979...93,725,930
Ensembl chr11:80,211,745...80,221,511
JBrowse link
G Fam151b family with sequence similarity 151, member B decreases expression ISO clothianidin results in decreased expression of FAM151B mRNA CTD PMID:31626844 NCBI chr 2:23,674,317...23,710,420
Ensembl chr 2:23,674,318...23,710,403
JBrowse link
G Fam169a family with sequence similarity 169, member A increases expression ISO clothianidin results in increased expression of FAM169A mRNA CTD PMID:29044138 NCBI chr 2:28,384,162...28,441,361
Ensembl chr 2:28,383,784...28,438,910
JBrowse link
G Fam229a family with sequence similarity 229, member A decreases expression ISO clothianidin results in decreased expression of FAM229A mRNA CTD PMID:29044138 NCBI chr 5:141,829,716...141,830,705
Ensembl chr 5:141,828,664...141,830,705
JBrowse link
G Faslg Fas ligand increases expression ISO clothianidin results in increased expression of FASLG mRNA CTD PMID:35264496 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fbxo33 F-box protein 33 decreases expression ISO clothianidin results in decreased expression of FBXO33 mRNA CTD PMID:31626844 NCBI chr 6:76,900,619...76,934,232
Ensembl chr 6:76,900,631...76,932,669
JBrowse link
G Fer1l4 fer-1-like family member 4 decreases expression ISO clothianidin results in decreased expression of FER1L4 mRNA CTD PMID:29044138 NCBI chr 3:164,996,183...165,031,719
Ensembl chr 3:144,536,099...144,571,634
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases expression ISO clothianidin results in increased expression of FGFR1 mRNA CTD PMID:36858607 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase increases expression ISO clothianidin results in increased expression of FHIT mRNA CTD PMID:35690182 NCBI chr15:16,365,401...17,872,901
Ensembl chr15:13,934,995...15,442,340
JBrowse link
G Filip1 filamin A interacting protein 1 increases expression ISO clothianidin results in increased expression of FILIP1 mRNA CTD PMID:31626844 NCBI chr 8:89,641,509...89,836,772
Ensembl chr 8:80,764,604...80,922,549
JBrowse link
G Fitm1 fat storage-inducing transmembrane protein 1 increases expression ISO clothianidin results in increased expression of FITM1 mRNA CTD PMID:31626844 NCBI chr15:33,034,705...33,035,974
Ensembl chr15:29,064,707...29,066,015
JBrowse link
G Folr2 folate receptor beta increases expression ISO clothianidin results in increased expression of FOLR2 mRNA CTD PMID:31626844 NCBI chr 1:165,612,047...165,630,382
Ensembl chr 1:156,200,060...156,205,724
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO clothianidin results in increased expression of FOSL1 mRNA CTD PMID:35690182 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Foxo1 forkhead box O1 increases expression ISO clothianidin results in increased expression of FOXO1 mRNA CTD PMID:31626844 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Foxo4 forkhead box O4 decreases expression ISO clothianidin results in decreased expression of FOXO4 mRNA CTD PMID:29044138 NCBI chr  X:70,425,218...70,432,120
Ensembl chr  X:66,385,558...66,392,115
JBrowse link
G Fyb1 FYN binding protein 1 decreases expression ISO clothianidin results in decreased expression of FYB1 mRNA CTD PMID:31626844 NCBI chr 2:57,360,084...57,508,609
Ensembl chr 2:55,632,698...55,779,629
JBrowse link
G Gabrg1 gamma-aminobutyric acid type A receptor subunit gamma 1 increases expression ISO clothianidin results in increased expression of GABRG1 mRNA CTD PMID:35264496 NCBI chr14:37,750,292...37,821,651
Ensembl chr14:37,396,294...37,635,956
JBrowse link
G Gabrp gamma-aminobutyric acid type A receptor subunit pi decreases expression ISO clothianidin results in decreased expression of GABRP mRNA CTD PMID:35264496 NCBI chr10:18,143,031...18,169,595
Ensembl chr10:18,143,038...18,169,516
JBrowse link
G Gask1a golgi associated kinase 1A increases expression ISO clothianidin results in increased expression of FAM198A mRNA CTD PMID:31626844 NCBI chr 8:130,488,279...130,521,242
Ensembl chr 8:121,610,787...121,642,942
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO clothianidin results in increased expression of GDF15 mRNA CTD PMID:35690182 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Ghrhr growth hormone releasing hormone receptor increases expression ISO clothianidin results in increased expression of GHRHR mRNA CTD PMID:31626844 NCBI chr 4:85,830,345...85,863,127
Ensembl chr 4:84,500,212...84,532,776
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression ISO clothianidin results in decreased expression of GLI1 mRNA CTD PMID:31626844 NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:63,156,926...63,169,251
JBrowse link
G Gngt1 G protein subunit gamma transducin 1 decreases expression ISO clothianidin results in decreased expression of GNGT1 mRNA CTD PMID:31626844 NCBI chr 4:32,960,945...32,963,930
Ensembl chr 4:32,006,267...32,009,252
JBrowse link
G Gnmt glycine N-methyltransferase decreases expression ISO clothianidin results in decreased expression of GNMT mRNA CTD PMID:35690182 NCBI chr 9:21,752,235...21,756,368
Ensembl chr 9:14,254,675...14,258,434
JBrowse link
G Gpc6 glypican 6 increases expression ISO clothianidin results in increased expression of GPC6 mRNA CTD PMID:31626844 NCBI chr15:100,437,415...101,435,038
Ensembl chr15:94,029,884...95,024,006
JBrowse link
G Gpcpd1 glycerophosphocholine phosphodiesterase 1 increases expression ISO clothianidin results in increased expression of GPCPD1 mRNA CTD PMID:31626844 NCBI chr 3:140,240,574...140,285,469
Ensembl chr 3:119,787,682...119,832,517
JBrowse link
G Gpihbp1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 increases expression ISO clothianidin results in increased expression of GPIHBP1 mRNA CTD PMID:31626844 NCBI chr 7:109,166,334...109,169,448
Ensembl chr 7:107,285,654...107,288,702
JBrowse link
G Gpr15lg G protein-coupled receptor 15 ligand decreases expression ISO clothianidin results in decreased expression of GPR15LG mRNA CTD PMID:31626844 NCBI chr16:12,888,528...12,896,134
Ensembl chr16:12,868,270...12,875,876
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO clothianidin results in decreased expression of GPX4 protein CTD PMID:25960033 PMID:33563863 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gramd1c GRAM domain containing 1C decreases expression ISO clothianidin results in decreased expression of GRAMD1C mRNA CTD PMID:31626844 NCBI chr11:70,139,076...70,224,478
Ensembl chr11:56,633,227...56,718,570
JBrowse link
G Gramd2a GRAM domain containing 2A decreases expression ISO clothianidin results in decreased expression of GRAMD2A mRNA CTD PMID:31626844 NCBI chr 8:60,079,744...60,117,788
Ensembl chr 8:60,080,338...60,115,842
JBrowse link
G Gskip GSK3B interacting protein increases expression ISO clothianidin results in increased expression of GSKIP mRNA CTD PMID:29044138 NCBI chr 6:124,586,087...124,609,106
Ensembl chr 6:124,586,070...124,609,100
JBrowse link
G Gtf3c5 general transcription factor IIIC subunit 5 increases expression ISO clothianidin results in increased expression of GTF3C5 mRNA CTD PMID:31626844 NCBI chr 3:11,893,867...11,914,187
Ensembl chr 3:11,893,875...11,914,180
JBrowse link
G Gtsf1l gametocyte specific factor 1-like increases expression ISO clothianidin results in increased expression of GTSF1L mRNA CTD PMID:31626844 NCBI chr 3:151,736,020...151,738,715
Ensembl chr 3:151,735,997...151,736,863
JBrowse link
G Gypc glycophorin C increases expression ISO clothianidin results in increased expression of GYPC mRNA CTD PMID:31626844 NCBI chr18:24,434,921...24,467,592
Ensembl chr18:24,160,739...24,193,204
JBrowse link
G H1f7 H1.7 linker histone increases expression ISO clothianidin results in increased expression of H1-7 mRNA CTD PMID:31626844 NCBI chr 7:129,408,521...129,409,888
Ensembl chr 7:129,408,359...129,409,930
JBrowse link
G Hacd2 3-hydroxyacyl-CoA dehydratase 2 increases expression ISO clothianidin results in increased expression of HACD2 mRNA CTD PMID:29044138 NCBI chr11:65,667,671...65,762,903
Ensembl chr11:65,670,281...65,762,889
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase increases expression ISO clothianidin results in increased expression of HCK mRNA CTD PMID:31626844 NCBI chr 3:162,031,833...162,074,933
Ensembl chr 3:141,571,587...141,614,693
JBrowse link
G Hectd2 HECT domain E3 ubiquitin protein ligase 2 increases expression ISO clothianidin results in increased expression of HECTD2 mRNA CTD PMID:29044138 NCBI chr 1:234,274,967...234,345,598
Ensembl chr 1:234,275,705...234,343,487
JBrowse link
G Hecw2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 decreases expression ISO clothianidin results in decreased expression of HECW2 mRNA CTD PMID:31626844 NCBI chr 9:62,853,904...63,247,472
Ensembl chr 9:55,365,203...55,580,327
JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO clothianidin results in decreased expression of HGF mRNA CTD PMID:31626844 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hid1 HID1 domain containing decreases expression ISO clothianidin results in decreased expression of HID1 mRNA CTD PMID:31626844 NCBI chr10:101,088,526...101,109,011
Ensembl chr10:100,589,555...100,610,041
JBrowse link
G Hmbs hydroxymethylbilane synthase increases expression ISO clothianidin results in increased expression of HMBS mRNA CTD PMID:31626844 NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Hnf1b HNF1 homeobox B increases expression ISO clothianidin results in increased expression of HNF1B mRNA CTD PMID:31626844 NCBI chr10:69,233,377...69,287,360
Ensembl chr10:68,735,894...68,789,888
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases expression ISO clothianidin results in increased expression of HNF4A mRNA CTD PMID:31626844 NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K decreases expression ISO clothianidin results in decreased expression of HNRNPK mRNA CTD PMID:31626844 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
JBrowse link
G Ift70b intraflagellar transport 70B decreases expression ISO clothianidin results in decreased expression of IFT70B mRNA CTD PMID:31626844 NCBI chr 3:60,855,809...60,858,380
Ensembl chr 3:60,855,575...60,858,389
JBrowse link
G Il17re interleukin 17 receptor E decreases expression ISO clothianidin results in decreased expression of IL17RE mRNA CTD PMID:29044138 NCBI chr 4:148,160,384...148,173,830
Ensembl chr 4:146,605,526...146,618,206
JBrowse link
G Il18bp interleukin 18 binding protein decreases expression ISO clothianidin results in decreased expression of IL18BP mRNA CTD PMID:29044138 NCBI chr 1:165,784,916...165,787,990
Ensembl chr 1:156,372,883...156,374,963
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma increases expression ISO clothianidin results in increased expression of IL2RG mRNA CTD PMID:31626844 NCBI chr  X:70,435,340...70,439,052
Ensembl chr  X:66,392,542...66,399,823
JBrowse link
G Immp1l inner mitochondrial membrane peptidase subunit 1 increases expression ISO clothianidin results in increased expression of IMMP1L mRNA CTD PMID:31626844 NCBI chr 3:112,840,015...112,904,297
Ensembl chr 3:92,385,379...92,452,313
JBrowse link
G Inhba inhibin subunit beta A increases expression ISO clothianidin results in increased expression of INHBA mRNA CTD PMID:33563863 NCBI chr17:53,787,159...53,810,942
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Insyn2b inhibitory synaptic factor family member 2B decreases expression ISO clothianidin results in decreased expression of INSYN2B mRNA CTD PMID:31626844 NCBI chr10:19,420,561...19,528,006
Ensembl chr10:19,003,131...19,022,139
JBrowse link
G Irx5 iroquois homeobox 5 decreases expression ISO clothianidin results in decreased expression of IRX5 mRNA CTD PMID:31626844 NCBI chr19:30,812,033...30,816,885
Ensembl chr19:14,624,225...14,642,318
JBrowse link
G Itsn1 intersectin 1 decreases expression ISO clothianidin results in decreased expression of ITSN1 mRNA CTD PMID:31626844 NCBI chr11:44,464,515...44,646,598
Ensembl chr11:30,978,590...31,160,645
JBrowse link
G Jak2 Janus kinase 2 decreases expression ISO clothianidin results in decreased expression of JAK2 mRNA CTD PMID:31626844 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Kat6b lysine acetyltransferase 6B decreases expression ISO clothianidin results in decreased expression of KAT6B mRNA CTD PMID:31626844 NCBI chr15:2,688,535...2,861,443
Ensembl chr15:2,639,200...2,812,316
JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 increases expression ISO clothianidin results in increased expression of KCNC4 mRNA CTD PMID:31626844 NCBI chr 2:195,063,967...195,100,244
Ensembl chr 2:195,071,769...195,099,233
JBrowse link
G Kcnd3 potassium voltage-gated channel subfamily D member 3 decreases expression ISO clothianidin results in decreased expression of KCND3 mRNA CTD PMID:31626844 NCBI chr 2:195,626,316...195,843,690
Ensembl chr 2:192,937,950...193,155,345
JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 decreases expression ISO clothianidin results in decreased expression of KCNK1 mRNA CTD PMID:31626844 NCBI chr19:70,856,985...70,895,053
Ensembl chr19:53,959,657...53,997,724
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 decreases expression ISO clothianidin results in decreased expression of KCNMA1 mRNA CTD PMID:31626844 PMID:35690182 NCBI chr15:351,065...1,057,117
Ensembl chr15:302,214...1,001,198
JBrowse link
G Kif7 kinesin family member 7 increases expression ISO clothianidin results in increased expression of KIF7 mRNA CTD PMID:31626844 NCBI chr 1:143,041,206...143,067,873
Ensembl chr 1:133,640,065...133,658,576
JBrowse link
G Kifc3 kinesin family member C3 increases expression ISO clothianidin results in increased expression of KIFC3 mRNA CTD PMID:31626844 NCBI chr19:9,831,159...9,926,405
Ensembl chr19:9,886,693...9,920,451
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase increases expression ISO clothianidin results in increased expression of KIT mRNA CTD PMID:31626844 NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Klhdc9 kelch domain containing 9 decreases expression ISO clothianidin results in decreased expression of KLHDC9 mRNA CTD PMID:31626844 NCBI chr13:83,790,390...83,794,080
Ensembl chr13:83,790,269...83,793,354
JBrowse link
G Kpna6 karyopherin subunit alpha 6 increases expression ISO clothianidin results in increased expression of KPNA6 mRNA CTD PMID:31626844 NCBI chr 5:147,272,466...147,307,523
Ensembl chr 5:141,991,568...142,021,120
JBrowse link
G Krt28 keratin 28 increases expression ISO clothianidin results in increased expression of KRT28 mRNA CTD PMID:31626844 NCBI chr10:84,318,352...84,328,693
Ensembl chr10:84,318,543...84,328,643
JBrowse link
G Ksr1 kinase suppressor of ras 1 decreases expression ISO clothianidin results in decreased expression of KSR1 mRNA CTD PMID:31626844 NCBI chr10:63,961,771...64,098,076
Ensembl chr10:63,961,759...64,098,076
JBrowse link
G Ky kyphoscoliosis peptidase multiple interactions
decreases expression
EXP [enilconazole co-treated with clothianidin] results in decreased expression of KY mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of KY mRNA
clothianidin results in decreased expression of KY mRNA
CTD PMID:33426623 NCBI chr 8:111,965,862...112,005,206
Ensembl chr 8:103,086,630...103,126,024
JBrowse link
G L3mbtl1 L3MBTL histone methyl-lysine binding protein 1 decreases expression ISO clothianidin results in decreased expression of L3MBTL1 mRNA CTD PMID:31626844 NCBI chr 3:151,597,903...151,633,657
Ensembl chr 3:151,602,980...151,631,233
JBrowse link
G Lgals12 galectin 12 increases expression ISO clothianidin results in increased expression of LGALS12 mRNA CTD PMID:31626844 NCBI chr 1:214,261,216...214,272,825
Ensembl chr 1:204,832,065...204,842,759
JBrowse link
G Lgi4 leucine-rich repeat LGI family, member 4 increases expression ISO clothianidin results in increased expression of LGI4 mRNA CTD PMID:31626844 NCBI chr 1:86,294,539...86,305,909
Ensembl chr 1:86,295,074...86,304,874
JBrowse link
G Lif LIF, interleukin 6 family cytokine decreases expression ISO clothianidin results in decreased expression of LIF mRNA CTD PMID:35690182 NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Lim2 lens intrinsic membrane protein 2 increases expression ISO clothianidin results in increased expression of LIM2 mRNA CTD PMID:31626844 NCBI chr 1:93,837,597...93,843,769
Ensembl chr 1:93,837,597...93,843,769
JBrowse link
G Lonrf1 LON peptidase N-terminal domain and ring finger 1 increases expression ISO clothianidin results in increased expression of LONRF1 mRNA CTD PMID:31626844 NCBI chr16:62,687,931...62,718,525
Ensembl chr16:55,984,463...56,015,156
JBrowse link
G Lox lysyl oxidase increases expression ISO clothianidin results in increased expression of LOX mRNA CTD PMID:29044138 NCBI chr18:48,162,889...48,175,640
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 decreases expression ISO clothianidin results in decreased expression of LPAR1 mRNA CTD PMID:31626844 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895
JBrowse link
G Lrig1 leucine-rich repeats and immunoglobulin-like domains 1 increases expression ISO clothianidin results in increased expression of LRIG1 mRNA CTD PMID:31626844 NCBI chr 4:128,687,723...128,788,219
Ensembl chr 4:127,130,898...127,231,513
JBrowse link
G Lrmda leucine rich melanocyte differentiation associated decreases expression ISO clothianidin results in decreased expression of LRMDA mRNA CTD PMID:35690182 NCBI chr15:1,275,139...2,334,153
Ensembl chr15:1,225,710...2,284,749
JBrowse link
G Lrrc74b leucine rich repeat containing 74B decreases expression ISO clothianidin results in decreased expression of LRRC74B mRNA CTD PMID:31626844 NCBI chr11:83,450,588...83,468,906
Ensembl chr11:83,450,624...83,468,922
JBrowse link
G Luzp2 leucine zipper protein 2 increases expression ISO clothianidin results in increased expression of LUZP2 mRNA CTD PMID:31626844 NCBI chr 1:105,597,291...105,983,605
Ensembl chr 1:105,597,307...105,981,183
JBrowse link
G Lysmd2 LysM domain containing 2 decreases expression ISO clothianidin results in decreased expression of LYSMD2 mRNA CTD PMID:31626844 NCBI chr 8:76,378,984...76,394,396
Ensembl chr 8:76,379,219...76,394,654
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO clothianidin results in increased phosphorylation of MAPK1 protein CTD PMID:31626844 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO clothianidin results in increased phosphorylation of MAPK3 protein CTD PMID:31626844 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mchr1 melanin-concentrating hormone receptor 1 increases expression ISO clothianidin results in increased expression of MCHR1 mRNA CTD PMID:31626844 NCBI chr 7:114,641,721...114,644,913
Ensembl chr 7:112,761,554...112,764,032
JBrowse link
G Megf11 multiple EGF-like-domains 11 multiple interactions
decreases expression
EXP [enilconazole co-treated with clothianidin] results in decreased expression of MEGF11 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of MEGF11 mRNA
clothianidin results in decreased expression of MEGF11 mRNA
CTD PMID:33426623 NCBI chr 8:73,787,568...74,113,228
Ensembl chr 8:64,892,387...65,216,061
JBrowse link
G Meioc meiosis specific with coiled-coil domain increases expression ISO clothianidin results in increased expression of MEIOC mRNA CTD PMID:31626844 NCBI chr10:88,128,939...88,147,833
Ensembl chr10:87,628,875...87,646,752
JBrowse link
G Mettl16 methyltransferase 16, RNA N6-adenosine increases expression ISO clothianidin results in increased expression of METTL16 mRNA CTD PMID:31626844 NCBI chr10:60,139,317...60,185,438
Ensembl chr10:59,640,972...59,687,061
JBrowse link
G Mical1 microtubule associated monooxygenase, calponin and LIM domain containing 1 increases expression ISO clothianidin results in increased expression of MICAL1 mRNA CTD PMID:31626844 NCBI chr20:44,974,137...44,986,089
Ensembl chr20:44,974,138...44,986,089
JBrowse link
G Micall2 MICAL-like 2 decreases expression ISO clothianidin results in decreased expression of MICALL2 mRNA CTD PMID:29044138 NCBI chr12:14,899,188...14,927,949
Ensembl chr12:14,899,157...14,927,946
JBrowse link
G Mlana melan-A increases expression ISO clothianidin results in increased expression of MLANA mRNA CTD PMID:31626844 NCBI chr 1:236,883,075...236,897,693
Ensembl chr 1:227,469,537...227,483,343
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions
increases expression
EXP [enilconazole co-treated with clothianidin] results in increased expression of MME mRNA; [thiacloprid co-treated with clothianidin] results in increased expression of MME mRNA
clothianidin results in increased expression of MME mRNA
CTD PMID:33426623 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression ISO clothianidin results in increased expression of MMP10 mRNA CTD PMID:31626844 NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Ms4a2 membrane spanning 4-domains A2 decreases expression ISO clothianidin results in decreased expression of MS4A2 mRNA CTD PMID:29044138 NCBI chr 1:217,864,855...217,873,934
Ensembl chr 1:208,440,361...208,448,310
JBrowse link
G Mss51 MSS51 mitochondrial translational activator decreases expression ISO clothianidin results in decreased expression of MSS51 mRNA CTD PMID:29044138 NCBI chr15:3,805,240...3,819,385
Ensembl chr15:3,807,516...3,819,385
JBrowse link
G Mtg1 mitochondrial ribosome-associated GTPase 1 decreases expression ISO clothianidin results in decreased expression of MTG1 mRNA CTD PMID:29044138 NCBI chr 1:194,931,543...194,944,278
Ensembl chr 1:194,931,531...194,944,277
JBrowse link
G Myl11 myosin light chain 11 decreases expression ISO clothianidin results in decreased expression of MYL11 mRNA CTD PMID:31626844 NCBI chr 1:181,829,703...181,832,546
Ensembl chr 1:181,829,743...181,832,545
JBrowse link
G Myl4 myosin, light chain 4 decreases expression ISO clothianidin results in decreased expression of MYL4 mRNA CTD PMID:31626844 NCBI chr10:89,949,733...89,985,308
Ensembl chr10:89,449,443...89,485,363
JBrowse link
G Myl6 myosin light chain 6 decreases expression ISO clothianidin results in decreased expression of MYL6 mRNA CTD PMID:31626844 NCBI chr 7:1,495,301...1,498,512
Ensembl chr 7:910,774...933,791
JBrowse link
G Myo3b myosin IIIB increases expression ISO clothianidin results in increased expression of MYO3B mRNA CTD PMID:31626844 NCBI chr 3:75,228,017...75,636,272
Ensembl chr 3:54,820,251...55,227,373
JBrowse link
G Myorg myogenesis regulating glycosidase increases expression ISO clothianidin results in increased expression of MYORG mRNA CTD PMID:29044138 NCBI chr 5:61,452,956...61,460,500
Ensembl chr 5:56,648,643...56,664,440
JBrowse link
G Myt1l myelin transcription factor 1-like increases expression ISO clothianidin results in increased expression of MYT1L mRNA CTD PMID:31626844 NCBI chr 6:51,892,858...52,291,830
Ensembl chr 6:46,428,150...46,561,671
JBrowse link
G N4bp2l1 NEDD4 binding protein 2-like 1 increases expression ISO clothianidin results in increased expression of N4BP2L1 mRNA CTD PMID:31626844 NCBI chr12:4,938,199...4,965,003
Ensembl chr12:102,573...127,257
JBrowse link
G Nadsyn1 NAD synthetase 1 decreases expression ISO clothianidin results in decreased expression of NADSYN1 mRNA CTD PMID:31626844 NCBI chr 1:198,981,559...199,009,853
Ensembl chr 1:198,981,604...199,009,869
JBrowse link
G Nasp nuclear autoantigenic sperm protein decreases expression ISO clothianidin results in decreased expression of NASP mRNA CTD PMID:31626844 NCBI chr 5:135,294,599...135,319,992
Ensembl chr 5:130,057,363...130,082,928
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 increases expression ISO clothianidin results in increased expression of NCF2 mRNA CTD PMID:35690182 NCBI chr13:67,505,492...67,536,015
Ensembl chr13:64,955,503...64,986,277
JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 increases expression ISO clothianidin results in increased expression of NDUFA10 mRNA CTD PMID:31626844 NCBI chr 9:100,454,498...100,490,023
Ensembl chr 9:93,007,042...93,042,560
JBrowse link
G Nectin4 nectin cell adhesion molecule 4 decreases expression ISO clothianidin results in decreased expression of NECTIN4 mRNA CTD PMID:35690182 NCBI chr13:86,335,027...86,354,152
Ensembl chr13:83,803,184...83,821,709
JBrowse link
G Neurod4 neuronal differentiation 4 decreases expression ISO clothianidin results in decreased expression of NEUROD4 mRNA CTD PMID:31626844 NCBI chr 7:7,090,048...7,102,018
Ensembl chr 7:7,090,045...7,102,030
JBrowse link
G Ngef neuronal guanine nucleotide exchange factor increases expression ISO clothianidin results in increased expression of NGEF mRNA CTD PMID:31626844 NCBI chr 9:95,594,823...95,692,381
Ensembl chr 9:88,146,956...88,244,914
JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO clothianidin results in increased expression of NGFR mRNA CTD PMID:29044138 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Ninl ninein-like decreases expression ISO clothianidin results in decreased expression of NINL mRNA CTD PMID:35690182 NCBI chr 3:160,208,757...160,275,077
Ensembl chr 3:139,748,355...139,814,622
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO clothianidin results in increased expression of NOS2 mRNA CTD PMID:31626844 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression
multiple interactions
ISO clothianidin results in decreased expression of NR0B2 mRNA
[clothianidin co-treated with enilconazole] results in decreased expression of NR0B2 mRNA
CTD PMID:32201337 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Ntn4 netrin 4 decreases expression ISO clothianidin results in decreased expression of NTN4 mRNA CTD PMID:31626844 NCBI chr 7:30,073,637...30,187,407
Ensembl chr 7:28,186,611...28,300,390
JBrowse link
G Nts neurotensin decreases expression ISO clothianidin results in decreased expression of NTS mRNA CTD PMID:31626844 NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:37,564,533...37,574,423
JBrowse link
G Nxnl2 nucleoredoxin-like 2 increases expression ISO clothianidin results in increased expression of NXNL2 mRNA CTD PMID:31626844 NCBI chr17:14,182,849...14,187,595
Ensembl chr17:14,031,153...14,036,189
JBrowse link
G Nxph2 neurexophilin 2 increases expression ISO clothianidin results in increased expression of NXPH2 mRNA CTD PMID:31626844 NCBI chr 3:26,373,858...26,392,392
Ensembl chr 3:5,756,621...5,987,008
JBrowse link
G Ocrl OCRL, inositol polyphosphate-5-phosphatase decreases expression ISO clothianidin results in decreased expression of OCRL mRNA CTD PMID:31626844 NCBI chr  X:127,089,508...127,140,362
Ensembl chr  X:127,089,590...127,140,362
JBrowse link
G Olr59 olfactory receptor 59 increases expression ISO clothianidin results in increased expression of OR51E2 mRNA CTD PMID:31626844 NCBI chr 1:166,604,972...166,639,634
Ensembl chr 1:157,193,080...157,211,179
JBrowse link
G Otud6b OTU deubiquitinase 6B increases expression ISO clothianidin results in increased expression of OTUD6B mRNA CTD PMID:29044138 NCBI chr 5:32,979,190...33,011,781
Ensembl chr 5:28,023,594...28,214,334
JBrowse link
G Padi4 peptidyl arginine deiminase 4 increases expression ISO clothianidin results in increased expression of PADI4 mRNA CTD PMID:31626844 NCBI chr 5:158,324,417...158,357,466
Ensembl chr 5:153,041,352...153,074,362
JBrowse link
G Pak5 p21 (RAC1) activated kinase 5 decreases expression ISO clothianidin results in decreased expression of PAK5 mRNA CTD PMID:31626844 PMID:35690182 NCBI chr 3:143,848,404...144,156,674
Ensembl chr 3:123,396,497...123,703,930
JBrowse link
G Paqr8 progestin and adipoQ receptor family member 8 decreases expression ISO clothianidin results in decreased expression of PAQR8 mRNA CTD PMID:29044138 NCBI chr 9:23,312,521...23,362,175
Ensembl chr 9:23,312,585...23,362,340
JBrowse link
G Pbld1 phenazine biosynthesis-like protein domain containing 1 decreases expression ISO clothianidin results in decreased expression of PBLD mRNA CTD PMID:31626844 NCBI chr20:25,549,974...25,565,390
Ensembl chr20:25,551,275...25,565,614
JBrowse link
G Pcca propionyl-CoA carboxylase subunit alpha decreases expression ISO clothianidin results in decreased expression of PCCA mRNA CTD PMID:32201337 NCBI chr15:106,034,586...106,374,908
Ensembl chr15:99,627,982...99,968,266
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 decreases expression ISO clothianidin results in decreased expression of PCSK1 mRNA CTD PMID:31626844 NCBI chr 2:6,130,045...6,176,974
Ensembl chr 2:4,395,543...4,442,434
JBrowse link
G Pde10a phosphodiesterase 10A decreases expression ISO clothianidin results in decreased expression of PDE10A mRNA CTD PMID:31626844 NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:51,770,132...52,216,563
JBrowse link
G Pde1c phosphodiesterase 1C increases expression ISO clothianidin results in increased expression of PDE1C mRNA CTD PMID:31626844 NCBI chr 4:86,629,074...87,108,147
Ensembl chr 4:85,300,858...85,863,219
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein increases expression ISO clothianidin results in increased expression of PDE4DIP mRNA CTD PMID:31626844 NCBI chr 2:187,982,002...188,178,937
Ensembl chr 2:185,293,214...185,468,379
JBrowse link
G Pdzd7 PDZ domain containing 7 decreases expression ISO clothianidin results in decreased expression of PDZD7 mRNA CTD PMID:29044138 NCBI chr 1:253,837,454...253,856,919
Ensembl chr 1:243,888,281...243,906,839
JBrowse link
G Peli2 pellino E3 ubiquitin protein ligase family member 2 decreases expression ISO clothianidin results in decreased expression of PELI2 mRNA CTD PMID:31626844 NCBI chr15:21,393,262...21,537,737
Ensembl chr15:21,393,262...21,535,106
JBrowse link
G Pgap6 post-GPI attachment to proteins 6 decreases expression ISO clothianidin results in decreased expression of PGAP6 mRNA CTD PMID:31626844 NCBI chr10:15,643,081...15,652,912
Ensembl chr10:15,138,959...15,148,431
JBrowse link
G Pgr progesterone receptor increases expression ISO clothianidin results in increased expression of PGR mRNA CTD PMID:33563863 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pheta2 PH domain containing endocytic trafficking adaptor 2 increases expression ISO clothianidin results in increased expression of FAM109B mRNA CTD PMID:31626844 NCBI chr 7:113,855,437...113,861,910
Ensembl chr 7:113,857,249...113,861,871
JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta decreases expression ISO clothianidin results in decreased expression of PIK3C2B mRNA CTD PMID:31626844 NCBI chr13:47,046,866...47,107,733
Ensembl chr13:44,495,050...44,555,612
JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma decreases expression ISO clothianidin results in decreased expression of PIP5K1C mRNA CTD PMID:31626844 NCBI chr 7:9,048,135...9,076,751
Ensembl chr 7:8,397,406...8,425,988
JBrowse link
G Pip5kl1 phosphatidylinositol-4-phosphate 5-kinase-like 1 decreases expression ISO clothianidin results in decreased expression of PIP5KL1 mRNA CTD PMID:29044138 NCBI chr 3:15,860,493...15,869,264
Ensembl chr 3:15,855,946...15,869,165
JBrowse link
G Pla2g2a phospholipase A2 group IIA increases expression ISO clothianidin results in increased expression of PLA2G2A mRNA CTD PMID:31626844 NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Plbd1 phospholipase B domain containing 1 decreases expression ISO clothianidin results in decreased expression of PLBD1 mRNA CTD PMID:31626844 NCBI chr 4:171,204,198...171,260,488
Ensembl chr 4:169,472,983...169,529,277
JBrowse link
G Plcd1 phospholipase C, delta 1 increases expression ISO clothianidin results in increased expression of PLCD1 mRNA CTD PMID:31626844 NCBI chr 8:127,672,955...127,695,939
Ensembl chr 8:118,795,201...118,818,186
JBrowse link
G Plcd3 phospholipase C, delta 3 decreases expression ISO clothianidin results in decreased expression of PLCD3 mRNA CTD PMID:31626844 NCBI chr10:88,526,802...88,548,116
Ensembl chr10:88,026,740...88,048,296
JBrowse link
G Plcl1 phospholipase C-like 1 decreases expression ISO clothianidin results in decreased expression of PLCL1 mRNA CTD PMID:31626844 NCBI chr 9:56,901,573...57,238,782
Ensembl chr 9:56,901,534...57,238,782
JBrowse link
G Pllp plasmolipin increases expression ISO clothianidin results in increased expression of PLLP mRNA CTD PMID:31626844 NCBI chr19:10,321,080...10,341,869
Ensembl chr19:10,315,104...10,335,892
JBrowse link
G Pnpla1 patatin-like phospholipase domain containing 1 increases expression ISO clothianidin results in increased expression of PNPLA1 mRNA CTD PMID:31626844 NCBI chr20:6,917,993...6,952,157
Ensembl chr20:6,917,931...6,952,375
JBrowse link
G Polr2m RNA polymerase II subunit M decreases expression ISO clothianidin results in decreased expression of POLR2M mRNA CTD PMID:31626844 NCBI chr 8:81,012,770...81,020,201
Ensembl chr 8:72,131,530...72,243,036
JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C increases expression ISO clothianidin results in increased expression of PPP1R3C mRNA CTD PMID:29044138 NCBI chr 1:243,873,524...243,878,527
Ensembl chr 1:234,460,652...234,465,961
JBrowse link
G Ppp3cc protein phosphatase 3 catalytic subunit gamma increases expression ISO clothianidin results in increased expression of PPP3CC mRNA CTD PMID:31626844 NCBI chr15:51,699,586...51,771,763
Ensembl chr15:45,290,373...45,361,832
JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 increases expression ISO clothianidin results in increased expression of PRG3 mRNA CTD PMID:31626844 NCBI chr 3:70,071,970...70,078,103
Ensembl chr 3:70,072,497...70,078,102
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases expression ISO clothianidin results in decreased expression of PARK2 mRNA CTD PMID:35690182 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Prlr prolactin receptor decreases expression ISO clothianidin results in decreased expression of PRLR mRNA CTD PMID:29044138 NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:59,134,588...59,324,718
JBrowse link
G Prnd prion like protein doppel increases expression ISO clothianidin results in increased expression of PRND mRNA CTD PMID:31626844 NCBI chr 3:119,213,462...119,218,742
Ensembl chr 3:119,213,429...119,218,745
JBrowse link
G Prodh2 proline dehydrogenase 2 increases expression ISO clothianidin results in increased expression of PRODH2 mRNA CTD PMID:31626844 NCBI chr 1:94,881,000...94,894,609
Ensembl chr 1:85,753,644...85,767,162
JBrowse link
G Prr5l proline rich 5 like increases expression ISO clothianidin results in increased expression of PRR5L mRNA CTD PMID:31626844 NCBI chr 3:108,458,107...108,628,552
Ensembl chr 3:88,003,617...88,082,763
JBrowse link
G Prxl2b peroxiredoxin like 2B decreases expression ISO clothianidin results in decreased expression of PRXL2B mRNA CTD PMID:31626844 NCBI chr 5:170,744,953...170,747,556 JBrowse link
G Psen1 presenilin 1 decreases expression ISO clothianidin results in decreased expression of PSEN1 mRNA CTD PMID:35264496 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 decreases expression ISO clothianidin results in decreased expression of PSMC6 mRNA CTD PMID:31626844 NCBI chr15:21,022,314...21,043,785
Ensembl chr15:18,542,563...18,564,055
JBrowse link
G Ptgfr prostaglandin F receptor decreases expression ISO clothianidin results in decreased expression of PTGFR mRNA CTD PMID:31626844 NCBI chr 2:243,390,820...243,426,647
Ensembl chr 2:240,733,375...240,765,650
JBrowse link
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 increases expression ISO clothianidin results in increased expression of PTPN3 mRNA CTD PMID:29044138 NCBI chr 5:71,908,520...72,027,323
Ensembl chr 5:71,911,135...72,065,443
JBrowse link
G Ptprb protein tyrosine phosphatase, receptor type, B decreases expression ISO clothianidin results in decreased expression of PTPRB mRNA CTD PMID:31626844 NCBI chr 7:53,816,197...53,920,760
Ensembl chr 7:51,930,015...52,034,748
JBrowse link
G Ptpro protein tyrosine phosphatase, receptor type, O decreases expression ISO clothianidin results in decreased expression of PTPRO mRNA CTD PMID:29044138 NCBI chr 4:171,895,104...172,105,911
Ensembl chr 4:170,164,431...170,374,771
JBrowse link
G Qpct glutaminyl-peptide cyclotransferase increases expression ISO clothianidin results in increased expression of QPCT mRNA CTD PMID:31626844 NCBI chr 6:21,716,824...21,748,895
Ensembl chr 6:15,964,657...15,996,711
JBrowse link
G Rag1 recombination activating 1 decreases expression ISO clothianidin results in decreased expression of RAG1 mRNA CTD PMID:31626844 NCBI chr 3:108,372,087...108,383,184
Ensembl chr 3:87,917,004...87,928,291
JBrowse link
G Rapgefl1 Rap guanine nucleotide exchange factor like 1 decreases expression ISO clothianidin results in decreased expression of RAPGEFL1 mRNA CTD PMID:29044138 NCBI chr10:84,289,980...84,306,614
Ensembl chr10:83,793,694...83,810,371
JBrowse link
G Rbm26 RNA binding motif protein 26 decreases expression ISO clothianidin results in decreased expression of RBM26 mRNA CTD PMID:31626844 NCBI chr15:81,884,783...81,964,245
Ensembl chr15:81,887,219...81,964,118
JBrowse link
G Rbms1 RNA binding motif, single stranded interacting protein 1 decreases expression ISO clothianidin results in decreased expression of RBMS1 mRNA CTD PMID:31626844 NCBI chr 3:45,195,828...45,420,406
Ensembl chr 3:45,197,972...45,420,376
JBrowse link
G Reg3g regenerating family member 3 gamma increases expression ISO clothianidin results in increased expression of REG3G mRNA CTD PMID:31626844 NCBI chr 4:112,482,183...112,484,738
Ensembl chr 4:110,924,168...110,926,723
JBrowse link
G Rfesd Rieske (Fe-S) domain containing decreases expression ISO clothianidin results in decreased expression of RFESD mRNA CTD PMID:31626844 NCBI chr 2:5,495,067...5,521,095
Ensembl chr 2:5,505,756...5,522,449
JBrowse link
G Riiad1 regulatory subunit of type II PKA R-subunit domain containing 1 decreases expression ISO clothianidin results in decreased expression of RIIAD1 mRNA CTD PMID:31626844 NCBI chr 2:184,788,948...184,807,344
Ensembl chr 2:182,101,795...182,110,319
JBrowse link
G Rnd1 Rho family GTPase 1 increases expression ISO clothianidin results in increased expression of RND1 mRNA CTD PMID:29044138 NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:129,821,311...129,828,399
JBrowse link
G Rp1l1 RP1 like 1 increases expression ISO clothianidin results in increased expression of RP1L1 mRNA CTD PMID:31626844 NCBI chr15:42,435,803...42,447,165
Ensembl chr15:38,259,928...38,270,316
JBrowse link
G Rps29 ribosomal protein S29 increases expression ISO clothianidin results in increased expression of RPS29 mRNA CTD PMID:31626844 NCBI chr 6:93,371,293...93,372,731
Ensembl chr 6:87,635,230...87,636,636
Ensembl chr13:87,635,230...87,636,636
JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator increases expression ISO clothianidin results in increased expression of RRAD mRNA CTD PMID:35690182 NCBI chr19:360,581...363,874
Ensembl chr19:354,198...357,417
JBrowse link
G RT1-Bb RT1 class II, locus Bb increases expression ISO clothianidin results in increased expression of HLA-DQB1 mRNA CTD PMID:31626844 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G S100a5 S100 calcium binding protein A5 decreases expression ISO clothianidin results in decreased expression of S100A5 mRNA CTD PMID:31626844 NCBI chr 2:176,095,332...176,099,546
Ensembl chr 2:176,097,539...176,099,546
JBrowse link
G Sash3 SAM and SH3 domain containing 3 increases expression ISO clothianidin results in increased expression of SASH3 mRNA CTD PMID:31626844 NCBI chr  X:132,204,717...132,219,421
Ensembl chr  X:127,326,859...127,341,519
JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 decreases expression ISO clothianidin results in decreased expression of SCN7A mRNA CTD PMID:31626844 NCBI chr 3:71,743,873...71,846,454
Ensembl chr 3:51,335,841...51,438,256
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta increases expression ISO clothianidin results in increased expression of SCNN1B mRNA CTD PMID:31626844 NCBI chr 1:185,861,326...185,915,717
Ensembl chr 1:176,430,103...176,484,451
JBrowse link
G Sema3f semaphorin 3F decreases expression ISO clothianidin results in decreased expression of SEMA3F mRNA CTD PMID:31626844 NCBI chr 8:117,236,269...117,265,206
Ensembl chr 8:108,357,629...108,387,083
JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 decreases expression ISO clothianidin results in decreased expression of SERP1 mRNA CTD PMID:31626844 NCBI chr 2:144,907,204...144,911,187
Ensembl chr 2:142,757,270...142,761,116
JBrowse link
G Serpina3n serpin family A member 3N decreases expression ISO clothianidin results in decreased expression of SERPINA3N mRNA CTD PMID:35264496 NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:123,323,629...123,332,433
JBrowse link
G Serpinc1 serpin family C member 1 decreases expression ISO clothianidin results in decreased expression of SERPINC1 mRNA CTD PMID:31626844 NCBI chr13:75,790,558...75,804,826
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO clothianidin results in decreased expression of SERPINE1 mRNA CTD PMID:31626844 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sgcd sarcoglycan, delta increases expression ISO clothianidin results in increased expression of SGCD mRNA CTD PMID:31626844 NCBI chr10:31,847,713...32,829,554
Ensembl chr10:31,280,511...31,724,840
JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 decreases expression ISO clothianidin results in decreased expression of SGK2 mRNA CTD PMID:29044138 NCBI chr 3:172,063,625...172,089,000
Ensembl chr 3:151,644,102...151,669,480
JBrowse link
G Sh3tc1 SH3 domain and tetratricopeptide repeats 1 increases expression ISO clothianidin results in increased expression of SH3TC1 mRNA CTD PMID:29044138 NCBI chr14:79,230,322...79,274,622
Ensembl chr14:75,016,875...75,049,995
JBrowse link
G Sipa1l2 signal-induced proliferation-associated 1 like 2 increases expression ISO clothianidin results in increased expression of SIPA1L2 mRNA CTD PMID:29044138 NCBI chr19:70,287,134...70,437,810
Ensembl chr19:53,389,805...53,540,428
JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) decreases expression ISO clothianidin results in decreased expression of SLC14A1 mRNA CTD PMID:31626844 NCBI chr18:73,840,568...73,883,925
Ensembl chr18:71,565,454...71,595,146
JBrowse link
G Slc17a7 solute carrier family 17 member 7 decreases expression ISO clothianidin results in decreased expression of SLC17A7 mRNA CTD PMID:31626844 NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:95,649,745...95,661,588
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO clothianidin results in decreased activity of SLC22A2 protein CTD PMID:31364238 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO clothianidin results in decreased activity of SLC22A6 protein CTD PMID:31364238 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity ISO clothianidin results in decreased activity of SLC22A8 protein CTD PMID:31364238 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc28a1 solute carrier family 28 member 1 increases expression ISO clothianidin results in increased expression of SLC28A1 mRNA CTD PMID:31626844 NCBI chr 1:144,490,453...144,532,025
Ensembl chr 1:135,081,385...135,122,464
JBrowse link
G Slc38a9 solute carrier family 38, member 9 decreases expression ISO clothianidin results in decreased expression of SLC38A9 mRNA CTD PMID:31626844 NCBI chr 2:46,024,731...46,102,419
Ensembl chr 2:44,291,989...44,368,955
JBrowse link
G Slc45a2 solute carrier family 45, member 2 decreases expression ISO clothianidin results in decreased expression of SLC45A2 mRNA CTD PMID:31626844 NCBI chr 2:61,690,828...61,723,437
Ensembl chr 2:59,963,706...59,996,317
JBrowse link
G Slc47a2 solute carrier family 47 member 2 decreases activity ISO clothianidin results in decreased activity of SLC47A2 protein CTD PMID:31364238 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Slc48a1 solute carrier family 48 member 1 increases expression ISO clothianidin results in increased expression of SLC48A1 mRNA CTD PMID:31626844 NCBI chr 7:128,915,136...128,923,929
Ensembl chr 7:128,915,195...128,923,024
JBrowse link
G Slc6a1 solute carrier family 6 member 1 decreases expression
multiple interactions
EXP clothianidin results in decreased expression of SLC6A1 mRNA
[enilconazole co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA
CTD PMID:33426623 NCBI chr 4:149,004,447...149,037,840
Ensembl chr 4:147,466,965...147,482,293
JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 increases expression ISO clothianidin results in increased expression of SLCO1C1 mRNA CTD PMID:31626844 NCBI chr 4:176,197,736...176,244,401
Ensembl chr 4:174,466,631...174,513,289
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 decreases expression ISO clothianidin results in decreased expression of SMPD3 mRNA CTD PMID:35690182 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:34,162,341...34,245,749
JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 increases expression ISO clothianidin results in increased expression of SORBS1 mRNA CTD PMID:31626844 NCBI chr 1:249,057,324...249,279,703
Ensembl chr 1:239,108,777...239,330,169
JBrowse link
G Spata3 spermatogenesis associated 3 increases expression ISO clothianidin results in increased expression of SPATA3 mRNA CTD PMID:31626844 NCBI chr 9:94,107,832...94,120,280
Ensembl chr 9:86,659,784...86,672,272
JBrowse link
G Spire2 spire-type actin nucleation factor 2 decreases expression ISO clothianidin results in decreased expression of SPIRE2 mRNA CTD PMID:29044138 NCBI chr19:51,373,368...51,411,920
Ensembl chr19:51,373,228...51,411,920
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 increases expression ISO clothianidin results in increased expression of SRD5A2 mRNA CTD PMID:31626844 NCBI chr 6:27,178,089...27,217,588
Ensembl chr 6:21,426,215...21,462,112
JBrowse link
G Sspo SCO-spondin decreases expression ISO clothianidin results in decreased expression of SSPOP mRNA CTD PMID:29044138 NCBI chr 4:78,725,829...78,781,330
Ensembl chr 4:77,397,059...77,450,412
JBrowse link
G Stac2 SH3 and cysteine rich domain 2 increases expression ISO clothianidin results in increased expression of STAC2 mRNA CTD PMID:31626844 NCBI chr10:83,528,741...83,544,583
Ensembl chr10:83,032,417...83,048,260
JBrowse link
G Steap2 STEAP2 metalloreductase increases expression ISO clothianidin results in increased expression of STEAP2 mRNA CTD PMID:31626844 NCBI chr 4:28,347,769...28,368,177
Ensembl chr 4:28,348,362...28,375,791
JBrowse link
G Susd4 sushi domain containing 4 increases expression ISO clothianidin results in increased expression of SUSD4 mRNA CTD PMID:31626844 NCBI chr13:96,982,867...97,109,419
Ensembl chr13:94,455,165...94,577,750
JBrowse link
G Sycp2 synaptonemal complex protein 2 decreases expression ISO clothianidin results in decreased expression of SYCP2 mRNA CTD PMID:29044138 NCBI chr 3:185,814,033...185,876,516
Ensembl chr 3:165,436,331...165,498,789
JBrowse link
G Synpo synaptopodin decreases expression ISO clothianidin results in decreased expression of SYNPO mRNA CTD PMID:29044138 NCBI chr18:56,326,369...56,347,359
Ensembl chr18:54,026,152...54,102,126
JBrowse link
G Tacr1 tachykinin receptor 1 increases expression ISO clothianidin results in increased expression of TACR1 mRNA CTD PMID:31626844 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tafa2 TAFA chemokine like family member 2 decreases expression ISO clothianidin results in decreased expression of FAM19A2 mRNA CTD PMID:31626844 NCBI chr 7:60,827,985...61,303,873
Ensembl chr 7:58,942,610...59,417,299
JBrowse link
G Tafa5 TAFA chemokine like family member 5 increases expression ISO clothianidin results in increased expression of FAM19A5 mRNA CTD PMID:31626844 NCBI chr 7:118,613,731...118,835,016
Ensembl chr 7:118,613,889...118,834,353
JBrowse link
G Tbx2 T-box transcription factor 2 increases expression ISO clothianidin results in increased expression of TBX2 mRNA CTD PMID:29044138 NCBI chr10:71,177,082...71,186,275
Ensembl chr10:70,679,518...70,688,529
JBrowse link
G Tcp10b t-complex protein 10b increases expression ISO clothianidin results in increased expression of TCP10L2 mRNA CTD PMID:31626844 NCBI chr 1:52,937,823...52,961,307
Ensembl chr 1:52,937,917...52,961,307
JBrowse link
G Tecpr1 tectonin beta-propeller repeat containing 1 decreases expression ISO clothianidin results in decreased expression of TECPR1 mRNA CTD PMID:31626844 NCBI chr12:15,504,456...15,534,541
Ensembl chr12:10,391,696...10,419,611
JBrowse link
G Tef TEF transcription factor, PAR bZIP family member increases expression ISO clothianidin results in increased expression of TEF mRNA CTD PMID:31626844 NCBI chr 7:115,197,180...115,221,930
Ensembl chr 7:113,317,283...113,341,783
JBrowse link
G Tgfbi transforming growth factor, beta induced increases expression ISO clothianidin results in increased expression of TGFBI mRNA CTD PMID:31626844 NCBI chr17:7,960,885...7,990,234
Ensembl chr17:7,955,603...7,985,240
JBrowse link
G Tgm5 transglutaminase 5 decreases expression ISO clothianidin results in decreased expression of TGM5 mRNA CTD PMID:29044138 NCBI chr 3:128,461,836...128,497,761
Ensembl chr 3:108,008,143...108,043,976
JBrowse link
G Thrsp thyroid hormone responsive decreases expression ISO clothianidin results in decreased expression of THRSP mRNA CTD PMID:35690182 NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 increases expression ISO clothianidin results in increased expression of TICAM1 mRNA CTD PMID:35264496 NCBI chr 9:1,189,717...1,197,730
Ensembl chr 9:1,102,366...1,123,147
JBrowse link
G Tifa TRAF-interacting protein with forkhead-associated domain increases expression ISO clothianidin results in increased expression of TIFA mRNA CTD PMID:31626844 NCBI chr 2:218,927,724...218,942,111
Ensembl chr 2:216,234,774...216,267,841
JBrowse link
G Tlcd4 TLC domain containing 4 increases expression ISO clothianidin results in increased expression of TLCD4 mRNA CTD PMID:29044138 NCBI chr 2:211,969,612...212,044,883
Ensembl chr 2:209,289,732...209,341,353
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO clothianidin results in increased expression of TLR2 mRNA CTD PMID:35264496 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlx3 T-cell leukemia, homeobox 3 decreases expression ISO clothianidin results in decreased expression of TLX3 mRNA CTD PMID:31626844 NCBI chr10:17,789,706...17,792,207
Ensembl chr10:17,790,053...17,792,207
JBrowse link
G Tmem273 transmembrane protein 273 increases expression ISO clothianidin results in increased expression of TMEM273 mRNA CTD PMID:31626844 NCBI chr16:8,049,565...8,081,981
Ensembl chr16:8,049,669...8,081,981
JBrowse link
G Tmem38a transmembrane protein 38a decreases expression ISO clothianidin results in decreased expression of TMEM38A mRNA CTD PMID:29044138 NCBI chr16:17,292,215...17,307,704
Ensembl chr16:17,258,164...17,273,415
JBrowse link
G Tmem71 transmembrane protein 71 decreases expression ISO clothianidin results in decreased expression of TMEM71 mRNA CTD PMID:31626844 NCBI chr 7:100,166,038...100,212,234
Ensembl chr 7:98,276,975...98,315,858
JBrowse link
G Tmt1a thiol methyltransferase 1A decreases expression ISO clothianidin results in decreased expression of TMT1A mRNA CTD PMID:29044138 NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO clothianidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; clothianidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:29044138 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B decreases expression ISO clothianidin results in decreased expression of TNFRSF11B mRNA CTD PMID:31626844 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnxb tenascin XB decreases expression ISO clothianidin results in decreased expression of TNXB mRNA CTD PMID:29044138
G Tpm1 tropomyosin 1 increases expression ISO clothianidin results in increased expression of TPM1 mRNA CTD PMID:29044138 NCBI chr 8:76,516,654...76,543,661
Ensembl chr 8:67,635,479...67,662,802
JBrowse link
G Traf4 Tnf receptor associated factor 4 increases expression ISO clothianidin results in increased expression of TRAF4 mRNA CTD PMID:29044138 NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284
JBrowse link
G Traf6 TNF receptor associated factor 6 decreases expression ISO clothianidin results in decreased expression of TRAF6 mRNA CTD PMID:29044138 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Trappc4 trafficking protein particle complex subunit 4 increases expression ISO clothianidin results in increased expression of TRAPPC4 mRNA CTD PMID:31626844 NCBI chr 8:53,626,382...53,630,042
Ensembl chr 8:44,725,331...44,733,491
JBrowse link
G Trim37 tripartite motif-containing 37 decreases expression ISO clothianidin results in decreased expression of TRIM37 mRNA CTD PMID:31626844 NCBI chr10:72,440,672...72,572,831
Ensembl chr10:71,943,375...72,075,558
JBrowse link
G Trmt44 tRNA methyltransferase 44 increases expression ISO clothianidin results in increased expression of TRMT44 mRNA CTD PMID:31626844 NCBI chr14:75,175,331...75,204,291
Ensembl chr14:75,182,029...75,200,147
JBrowse link
G Tssk6 testis-specific serine kinase 6 decreases expression ISO clothianidin results in decreased expression of TSSK6 mRNA CTD PMID:31626844 NCBI chr16:19,523,626...19,526,074
Ensembl chr16:19,517,334...19,526,090
JBrowse link
G Ttc28 tetratricopeptide repeat domain 28 decreases expression ISO clothianidin results in decreased expression of TTC28 mRNA CTD PMID:31626844 NCBI chr12:51,002,816...51,443,461
Ensembl chr12:45,345,399...45,783,547
JBrowse link
G Ttc33 tetratricopeptide repeat domain 33 decreases expression ISO clothianidin results in decreased expression of TTC33 mRNA CTD PMID:31626844 NCBI chr 2:54,279,906...54,326,851
Ensembl chr 2:54,279,997...54,323,871
JBrowse link
G Ttc8 tetratricopeptide repeat domain 8 decreases expression ISO clothianidin results in decreased expression of TTC8 mRNA CTD PMID:31626844 NCBI chr 6:123,927,657...124,025,354
Ensembl chr 6:118,198,201...118,252,418
JBrowse link
G Tubgcp3 tubulin gamma complex component 3 increases expression ISO clothianidin results in increased expression of TUBGCP3 mRNA CTD PMID:31626844 NCBI chr16:83,553,950...83,614,626
Ensembl chr16:76,851,810...76,912,499
JBrowse link
G Txndc2 thioredoxin domain containing 2 increases expression ISO clothianidin results in increased expression of TXNDC2 mRNA CTD PMID:31626844 NCBI chr 9:112,677,459...112,682,027
Ensembl chr 9:105,230,578...105,235,126
JBrowse link
G Ubap1l ubiquitin associated protein 1-like decreases expression
increases expression
ISO clothianidin results in decreased expression of UBAP1L mRNA
clothianidin results in increased expression of UBAP1L mRNA
CTD PMID:29044138 PMID:31626844 NCBI chr 8:74,772,794...74,792,753
Ensembl chr 8:65,884,729...65,897,593
JBrowse link
G Unc119b unc-119 lipid binding chaperone B increases expression ISO clothianidin results in increased expression of UNC119B mRNA CTD PMID:31626844 NCBI chr12:41,478,808...41,491,432
Ensembl chr12:41,478,808...41,491,432
JBrowse link
G Usp43 ubiquitin specific peptidase 43 decreases expression ISO clothianidin results in decreased expression of USP43 mRNA CTD PMID:31626844 NCBI chr10:52,549,200...52,611,168
Ensembl chr10:52,548,963...52,611,533
JBrowse link
G Utrn utrophin decreases expression ISO clothianidin results in decreased expression of UTRN mRNA CTD PMID:31626844 NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:6,722,594...7,224,313
JBrowse link
G Vamp8 vesicle-associated membrane protein 8 increases expression ISO clothianidin results in increased expression of VAMP8 mRNA CTD PMID:31626844 NCBI chr 4:106,000,570...106,011,081
Ensembl chr 4:104,442,393...104,452,897
JBrowse link
G Vegfd vascular endothelial growth factor D decreases expression ISO clothianidin results in decreased expression of VEGFD mRNA CTD PMID:31626844 NCBI chr  X:33,704,582...33,740,305
Ensembl chr  X:30,074,163...30,108,295
JBrowse link
G Vps8 VPS8 subunit of CORVET complex decreases expression ISO clothianidin results in decreased expression of VPS8 mRNA CTD PMID:31626844 NCBI chr11:79,402,236...79,634,234
Ensembl chr11:79,402,239...79,634,133
JBrowse link
G Washc4 WASH complex subunit 4 increases expression ISO clothianidin results in increased expression of WASHC4 mRNA CTD PMID:31626844 NCBI chr 7:22,075,546...22,127,847
Ensembl chr 7:20,187,922...20,240,226
JBrowse link
G Whrn whirlin increases expression ISO clothianidin results in increased expression of WHRN mRNA CTD PMID:31626844 NCBI chr 5:81,843,820...81,933,400
Ensembl chr 5:76,828,301...76,912,223
JBrowse link
G Wnt7b Wnt family member 7B decreases expression ISO clothianidin results in decreased expression of WNT7B mRNA CTD PMID:35690182 NCBI chr 7:118,514,684...118,559,316
Ensembl chr 7:116,634,814...116,679,581
JBrowse link
G Ypel2 yippee-like 2 increases expression ISO clothianidin results in increased expression of YPEL2 mRNA CTD PMID:31626844 NCBI chr10:71,746,308...71,803,843
Ensembl chr10:71,746,311...71,803,911
JBrowse link
G Ypel3 yippee-like 3 decreases expression ISO clothianidin results in decreased expression of YPEL3 mRNA CTD PMID:29044138 NCBI chr 1:190,814,920...190,818,248
Ensembl chr 1:181,384,357...181,387,705
JBrowse link
G Zbtb45 zinc finger and BTB domain containing 45 decreases expression ISO clothianidin results in decreased expression of ZBTB45 mRNA CTD PMID:31626844 NCBI chr 1:73,634,895...73,639,802
Ensembl chr 1:73,635,448...73,639,556
JBrowse link
G Zcchc13 zinc finger CCHC-type containing 13 decreases expression ISO clothianidin results in decreased expression of ZCCHC13 mRNA CTD PMID:31626844 NCBI chr  X:68,643,568...68,644,671
Ensembl chr  X:68,643,549...68,665,131
JBrowse link
G Zfp18 zinc finger protein 18 decreases expression ISO clothianidin results in decreased expression of ZNF18 mRNA CTD PMID:31626844 NCBI chr10:50,972,531...50,994,796
Ensembl chr10:50,473,483...50,495,706
JBrowse link
G Zfp219 zinc finger protein 219 decreases expression ISO clothianidin results in decreased expression of ZNF219 mRNA CTD PMID:29044138 NCBI chr15:27,169,335...27,183,555
Ensembl chr15:24,695,837...24,710,030
JBrowse link
G Zfp467 zinc finger protein 467 increases expression ISO clothianidin results in increased expression of ZNF467 mRNA CTD PMID:31626844 NCBI chr 4:78,716,473...78,725,829
Ensembl chr 4:77,385,758...77,392,229
JBrowse link
G Zfp470 zinc finger protein 470 increases expression ISO clothianidin results in increased expression of ZNF470 mRNA CTD PMID:31626844 NCBI chr 1:100,200,601...100,248,567
Ensembl chr 1:91,087,361...91,112,065
JBrowse link
G Zfp502 zinc finger protein 502 increases expression ISO clothianidin results in increased expression of ZNF502 mRNA CTD PMID:31626844 NCBI chr 1:30,712,974...30,737,956 JBrowse link
G Zfp521 zinc finger protein 521 decreases expression ISO clothianidin results in decreased expression of ZNF521 mRNA CTD PMID:31626844 NCBI chr18:5,050,297...5,343,188
Ensembl chr18:4,787,295...5,068,458
JBrowse link
G Zfp653 zinc finger protein 653 decreases expression ISO clothianidin results in decreased expression of ZNF653 mRNA CTD PMID:31626844 NCBI chr 8:20,586,607...20,605,439
Ensembl chr 8:20,586,563...20,604,864
JBrowse link
G Zfp865 zinc finger protein 865 increases expression ISO clothianidin results in increased expression of ZNF784 mRNA CTD PMID:31626844 NCBI chr 1:68,805,302...68,809,780
Ensembl chr 1:68,805,302...68,809,780
JBrowse link
G Zkscan7 zinc finger with KRAB and SCAN domains 7 increases expression ISO clothianidin results in increased expression of ZKSCAN7 mRNA CTD PMID:31626844 NCBI chr 8:122,501,938...122,519,600
Ensembl chr 8:122,502,218...122,519,600
JBrowse link
G Zswim4 zinc finger, SWIM-type containing 4 decreases expression ISO clothianidin results in decreased expression of ZSWIM4 mRNA CTD PMID:31626844 NCBI chr19:40,832,608...40,857,742
Ensembl chr19:23,927,845...23,952,970
JBrowse link
cytisine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions ISO
EXP
cytisine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]
cytisine affects binding to Chrna2 protein; cytisine inhibits the reaction [epibatidine affects binding to Chrna2 protein] in rat retina
CTD
RGD
PMID:9454827 PMID:16129735 RGD:2303195 NCBI chr15:44,517,862...44,534,144
Ensembl chr15:40,342,317...40,358,601
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO
EXP
cytisine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]
cytisine affects binding [Epibatidine binds to Chrna3 protein]
cytisine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD
RGD
PMID:9454827 PMID:11600638 PMID:16129735 RGD:2303195 NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects expression
affects binding
ISO
EXP
cytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; cytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; cytisine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; cytisine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; pozanicline inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]
cytisine affects binding to Chrna4 protein; cytisine inhibits the reaction [epibatidine affects binding to Chrna4 protein] in rat retina
cytisine affects binding to Chrna4 protein; cytisine competes with [Epibatidine binds to Chrna4 protein]
cytisine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
cytisine affects the expression of CHRNA4 protein
CTD
RGD
PMID:7756618 PMID:9336329 PMID:9454827 PMID:14645658 PMID:20331614 More... RGD:2303195, RGD:2303194 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO
EXP
cytisine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]
cytisine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]
CTD PMID:10216184 PMID:19448648 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
affects expression
ISO
EXP
cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]
cytisine affects binding to Chrnb2 protein; cytisine inhibits the reaction [epibatidine affects binding to Chrnb2 protein] in rat retina
cytisine affects binding to Chrnb2 protein; cytisine competes with [Epibatidine binds to Chrnb2 protein]
cytisine affects the expression of CHRNB2 protein
cytisine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]
cytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; cytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; cytisine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; pozanicline inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]
CTD
RGD
PMID:7756618 PMID:9336329 PMID:14645658 PMID:20331614 PMID:16129735 More... RGD:2303195, RGD:2303194 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit multiple interactions EXP cytisine affects binding to Chrnb3 protein; cytisine inhibits the reaction [epibatidine affects binding to Chrnb3 protein] in rat retina RGD PMID:16129735 RGD:2303195 NCBI chr16:71,411,847...71,454,225
Ensembl chr16:64,714,169...64,751,360
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO
EXP
cytisine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; cytisine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; cytisine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]
cytisine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD PMID:9454827 PMID:11600638 NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Ifng interferon gamma decreases secretion ISO cytisine analog results in decreased secretion of IFNG protein CTD PMID:17630191 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Tbx21 T-box transcription factor 21 decreases expression ISO cytisine analog results in decreased expression of TBX21 mRNA CTD PMID:17630191 NCBI chr10:82,578,751...82,595,253
Ensembl chr10:82,082,322...82,098,831
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO cytisine analog results in decreased secretion of TNF protein CTD PMID:17630191 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
decamethonium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO decamethonium results in decreased activity of BCHE protein CTD PMID:31173753 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; decamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; decamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
dinotefuran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP dinotefuran results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]; dinotefuran results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein] CTD PMID:16981889 PMID:25459289 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
flupyradifurone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases transport
ISO 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased transport of flupyradifurone] CTD PMID:37011773 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases activity ISO flupyradifurone results in increased activity of CHRNA7 protein; flupyradifurone results in increased activity of CHRNA7 protein mutant form CTD PMID:39393466 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
imidacloprid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1700012B07Rikl RIKEN cDNA 1700012B07 gene like multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of 1700012B07RIKL gene CTD PMID:33854195 NCBI chr10:94,771,471...94,804,839
Ensembl chr10:94,771,554...94,804,839
JBrowse link
G Acacb acetyl-CoA carboxylase beta multiple interactions ISO [imidacloprid co-treated with Dietary Fats] results in increased expression of ACACB mRNA CTD PMID:33487623 NCBI chr12:48,026,394...48,138,214
Ensembl chr12:42,366,548...42,457,655
JBrowse link
G Ache acetylcholinesterase increases activity
decreases activity
increases expression
EXP imidacloprid results in increased activity of ACHE protein
imidacloprid results in decreased activity of ACHE protein
imidacloprid results in increased expression of ACHE protein
CTD PMID:18080902 PMID:26024013 PMID:37648049 PMID:39002876 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acot2 acyl-CoA thioesterase 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of ACOT2 gene CTD PMID:33854195 NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Acot4 acyl-CoA thioesterase 4 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ACOT4 mRNA CTD PMID:33854195 NCBI chr 6:109,399,032...109,405,138
Ensembl chr 6:103,668,753...103,673,917
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression
decreases expression
ISO imidacloprid results in increased expression of ACOX1 mRNA
imidacloprid results in decreased expression of ACOX1 mRNA
CTD PMID:33487623 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acy1 aminoacylase 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ACY1 mRNA CTD PMID:33854195 NCBI chr 8:107,072,354...107,077,756
Ensembl chr 8:107,072,358...107,077,682
JBrowse link
G Adam15 ADAM metallopeptidase domain 15 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of ADAM15 gene CTD PMID:33854195 NCBI chr 2:177,052,363...177,062,879
Ensembl chr 2:174,754,633...174,765,113
JBrowse link
G Adamtsl3 ADAMTS-like 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of ADAMTSL3 gene CTD PMID:33854195 NCBI chr 1:145,698,004...146,006,195
Ensembl chr 1:136,288,793...136,596,986
JBrowse link
G Adcy6 adenylate cyclase 6 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of ADCY6 mRNA CTD PMID:33854195 NCBI chr 7:131,621,860...131,642,923
Ensembl chr 7:129,742,838...129,763,754
JBrowse link
G Adrm1 ADRM1 26S proteasome ubiquitin receptor multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ADRM1 mRNA CTD PMID:33854195 NCBI chr 3:187,643,043...187,647,805
Ensembl chr 3:167,265,296...167,270,195
JBrowse link
G Afp alpha-fetoprotein multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of AFP mRNA CTD PMID:33854195 NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Agt angiotensinogen multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of AGT mRNA CTD PMID:33854195 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Ahr aryl hydrocarbon receptor affects expression ISO imidacloprid affects the expression of AHR mRNA CTD PMID:35457321 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression EXP imidacloprid results in increased expression of AIF1 mRNA CTD PMID:39002876 NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Aig1 androgen-induced 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of AIG1 gene CTD PMID:33854195 NCBI chr 1:9,866,546...10,089,454
Ensembl chr 1:8,046,430...8,269,084
JBrowse link
G Akap8 A-kinase anchoring protein 8 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of AKAP8 mRNA CTD PMID:33854195 NCBI chr 7:11,966,769...11,983,056
Ensembl chr 7:11,316,228...11,332,399
JBrowse link
G Akap8l A-kinase anchoring protein 8 like multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of AKAP8L mRNA CTD PMID:33854195 NCBI chr 7:11,332,671...11,362,287
Ensembl chr 7:11,332,672...11,362,275
JBrowse link
G Alb albumin multiple interactions
decreases expression
EXP [imidacloprid co-treated with sodium arsenate] results in decreased expression of ALB protein
imidacloprid results in decreased expression of ALB protein
CTD PMID:30033815 PMID:34993831 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ALDH9A1 mRNA CTD PMID:33854195 NCBI chr13:79,505,738...79,522,539
Ensembl chr13:79,505,695...79,540,568
JBrowse link
G Alg2 ALG2, alpha-1,3/1,6-mannosyltransferase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ALG2 mRNA CTD PMID:33854195 NCBI chr 5:61,768,738...61,773,297
Ensembl chr 5:61,768,740...61,773,297
JBrowse link
G Ampd1 adenosine monophosphate deaminase 1 decreases expression EXP imidacloprid results in decreased expression of AMPD1 mRNA CTD PMID:27782041 NCBI chr 2:190,598,707...190,619,938
Ensembl chr 2:190,598,700...190,619,938
JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ANGPTL4 mRNA CTD PMID:33854195 NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Anks3 ankyrin repeat and sterile alpha motif domain containing 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of ANKS3 mRNA CTD PMID:33854195 NCBI chr10:11,121,504...11,142,261
Ensembl chr10:10,615,047...10,635,806
JBrowse link
G Anxa11 annexin A11 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ANXA11 mRNA CTD PMID:33854195 NCBI chr16:1,419,627...1,464,590
Ensembl chr16:1,410,756...1,457,797
JBrowse link
G Apc APC regulator of WNT signaling pathway affects methylation
multiple interactions
ISO imidacloprid affects the methylation of APC promoter
LIF protein affects the reaction [imidacloprid affects the methylation of APC promoter]
CTD PMID:33865946 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Aplf aprataxin and PNKP like factor multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of APLF mRNA CTD PMID:33854195 NCBI chr 4:121,627,800...121,679,980
Ensembl chr 4:120,070,471...120,122,633
JBrowse link
G Apof apolipoprotein F multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of APOF mRNA CTD PMID:33854195 NCBI chr 7:1,285,222...1,286,659
Ensembl chr 7:700,762...701,946
JBrowse link
G Ar androgen receptor decreases expression
affects expression
ISO imidacloprid results in decreased expression of AR mRNA; imidacloprid results in decreased expression of AR protein
imidacloprid affects the expression of AR mRNA
CTD PMID:31780179 PMID:35457321 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arf2 ADP-ribosylation factor 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of ARF2 mRNA CTD PMID:33854195 NCBI chr10:88,867,836...88,889,654
Ensembl chr10:88,867,836...88,889,659
JBrowse link
G Arpc1a actin related protein 2/3 complex, subunit 1A multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of ARPC1A gene CTD PMID:33854195 NCBI chr12:9,502,496...9,525,304
Ensembl chr12:9,502,501...9,525,330
JBrowse link
G Asb7 ankyrin repeat and SOCS box-containing 7 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of ASB7 mRNA CTD PMID:33854195 NCBI chr 1:120,222,835...120,267,411
Ensembl chr 1:120,222,745...120,267,282
JBrowse link
G Ass1 argininosuccinate synthase 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ASS1 mRNA CTD PMID:33854195 NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Atosa atos homolog A multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of ATOSA mRNA CTD PMID:33854195 NCBI chr 8:84,575,360...84,653,103
Ensembl chr 8:75,695,022...75,772,549
JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ATP5MC1 mRNA CTD PMID:33854195 NCBI chr10:81,520,762...81,523,735
Ensembl chr10:81,023,925...81,027,124
Ensembl chr10:81,023,925...81,027,124
JBrowse link
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ATP6V0D1 mRNA CTD PMID:33854195 NCBI chr19:33,403,352...33,447,357
Ensembl chr19:33,403,355...33,447,450
JBrowse link
G Bag3 BAG cochaperone 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of BAG3 mRNA CTD PMID:33854195 NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:183,102,871...183,126,858
JBrowse link
G Banp Btg3 associated nuclear protein multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of BANP mRNA CTD PMID:33854195 NCBI chr19:50,007,710...50,082,742
Ensembl chr19:50,007,881...50,082,738
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP imidacloprid results in increased expression of BAX mRNA; imidacloprid results in increased expression of BAX protein
Thymol inhibits the reaction [imidacloprid results in increased expression of BAX mRNA]
CTD PMID:27914857 PMID:34171690 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase increases activity EXP imidacloprid results in increased activity of BCHE protein CTD PMID:18080902 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
EXP imidacloprid results in decreased expression of BCL2 mRNA
Thymol inhibits the reaction [imidacloprid results in decreased expression of BCL2 mRNA]
CTD PMID:34171690 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP imidacloprid results in decreased expression of BCL2L1 mRNA CTD PMID:39002876 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479
JBrowse link
G Bcl9 BCL9, transcription coactivator multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of BCL9 mRNA CTD PMID:33854195 NCBI chr 2:187,449,425...187,475,241
Ensembl chr 2:184,760,618...184,786,435
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of BHMT mRNA CTD PMID:33854195 NCBI chr 2:26,594,852...26,614,429
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G C1qc complement C1q C chain multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of C1QC mRNA CTD PMID:33854195 NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:149,127,415...149,131,017
JBrowse link
G C8h11orf54 similar to human chromosome 11 open reading frame 54 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of C8H11ORF54 mRNA CTD PMID:33854195 NCBI chr 8:20,405,240...20,427,811
Ensembl chr 8:12,123,823...12,146,473
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases expression EXP imidacloprid results in increased expression of CACNA1H mRNA CTD PMID:27782041 NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Cacng1 calcium voltage-gated channel auxiliary subunit gamma 1 decreases expression EXP imidacloprid results in decreased expression of CACNG1 mRNA CTD PMID:27782041 NCBI chr10:93,152,558...93,165,246
Ensembl chr10:92,652,614...92,665,783
JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CAMK2G mRNA CTD PMID:33854195 NCBI chr15:3,553,238...3,612,310
Ensembl chr15:3,504,085...3,563,050
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 decreases expression
multiple interactions
ISO imidacloprid results in decreased expression of CAMKK2 protein
Dietary Fats promotes the reaction [imidacloprid results in decreased expression of CAMKK2 protein]
CTD PMID:27960282 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CAP1 mRNA CTD PMID:33854195 NCBI chr 5:140,427,265...140,507,678
Ensembl chr 5:135,142,112...135,168,769
JBrowse link
G Caps2 calcyphosine 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CAPS2 mRNA CTD PMID:33854195 NCBI chr 7:47,580,636...47,641,598
Ensembl chr 7:47,581,137...47,639,229
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
EXP imidacloprid results in increased expression of CASP3 mRNA; imidacloprid results in increased expression of CASP3 protein
Thymol inhibits the reaction [imidacloprid results in increased expression of CASP3 mRNA]; Thymol inhibits the reaction [imidacloprid results in increased expression of CASP3 protein]
CTD PMID:34171690 PMID:34993831 PMID:37648049 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases activity
decreases expression
multiple interactions
EXP imidacloprid results in decreased activity of CAT protein
imidacloprid results in decreased expression of CAT protein
imidacloprid promotes the reaction [sodium arsenate results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [imidacloprid results in decreased expression of CAT protein]; sodium arsenate promotes the reaction [imidacloprid results in decreased activity of CAT protein]; Thymol inhibits the reaction [imidacloprid results in decreased activity of CAT protein]
CTD PMID:20686345 PMID:30033815 PMID:30456172 PMID:34171690 PMID:35398170 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbs cystathionine beta synthase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CBS mRNA CTD PMID:33854195 NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Ccdc125 coiled-coil domain containing 125 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CCDC125 mRNA CTD PMID:33854195 NCBI chr 2:31,809,120...31,835,538
Ensembl chr 2:31,809,228...31,850,152
JBrowse link
G Ccdc81 coiled-coil domain containing 81 increases expression EXP imidacloprid results in increased expression of CCDC81 mRNA CTD PMID:27782041 NCBI chr 1:153,152,032...153,203,586
Ensembl chr 1:143,739,474...143,790,926
JBrowse link
G Ccnl1 cyclin L1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CCNL1 mRNA CTD PMID:33854195 NCBI chr 2:152,495,169...152,508,855
Ensembl chr 2:150,184,798...150,197,368
JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions
ISO imidacloprid results in increased expression of CD36 mRNA
[imidacloprid co-treated with Dietary Fats] results in decreased expression of CD36 mRNA; [imidacloprid co-treated with Dietary Fats] results in increased expression of CD36 mRNA
CTD PMID:27960282 PMID:33487623 NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cdh1 cadherin 1 multiple interactions
affects methylation
ISO LIF protein affects the reaction [imidacloprid affects the methylation of CDH1 promoter] CTD PMID:33865946 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CDKN1A mRNA CTD PMID:33854195 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects methylation
multiple interactions
ISO imidacloprid affects the methylation of CDKN2A promoter
LIF protein affects the reaction [imidacloprid affects the methylation of CDKN2A promoter]
CTD PMID:33865946 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CEBPD mRNA CTD PMID:33854195 NCBI chr11:98,268,856...98,269,994
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Celf6 CUGBP, Elav-like family member 6 increases expression EXP imidacloprid results in increased expression of CELF6 mRNA CTD PMID:27782041 NCBI chr 8:68,870,902...68,901,863
Ensembl chr 8:59,975,088...60,005,041
JBrowse link
G Cep85 centrosomal protein 85 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CEP85 mRNA CTD PMID:33854195 NCBI chr 5:151,640,316...151,687,891
Ensembl chr 5:146,356,576...146,404,060
JBrowse link
G Cerk ceramide kinase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CERK mRNA CTD PMID:33854195 NCBI chr 7:117,225,855...117,269,436
Ensembl chr 7:117,225,855...117,268,759
JBrowse link
G Cfb complement factor B multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CFB mRNA CTD PMID:33854195 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Cfl1 cofilin 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CFL1 mRNA CTD PMID:33854195 NCBI chr 1:212,227,124...212,230,656
Ensembl chr 1:202,786,627...202,817,587
JBrowse link
G Chat choline O-acetyltransferase increases expression EXP imidacloprid results in increased expression of CHAT mRNA CTD PMID:39002876 NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CHCHD10 mRNA CTD PMID:33854195 NCBI chr20:12,725,274...12,730,295
Ensembl chr20:12,725,842...12,732,763
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CHEK2 mRNA CTD PMID:33854195 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 increases expression EXP imidacloprid results in increased expression of CHRM1 mRNA CTD PMID:26568164 NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 increases expression EXP imidacloprid results in increased expression of CHRM2 protein CTD PMID:18080902 NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions EXP imidacloprid results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]; LYNX1 protein promotes the reaction [imidacloprid results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; LYPD1 protein promotes the reaction [imidacloprid results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]] CTD PMID:19619141 NCBI chr 3:78,862,286...78,877,353
Ensembl chr 3:58,454,744...58,469,840
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO imidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:34628512 NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP
ISO
imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; imidacloprid binds to [CHRNA4 protein co-treated with CHRNB2 protein]
imidacloprid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; imidacloprid results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; imidacloprid results in increased activity of [CHRNA4 protein binds to CHRNB4 protein]
CTD PMID:10377228 PMID:10728888 PMID:21538459 PMID:34628512 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases activity ISO imidacloprid metabolite results in increased activity of CHRNA7 protein; imidacloprid results in increased activity of CHRNA7 protein; imidacloprid results in increased activity of CHRNA7 protein mutant form CTD PMID:34628512 PMID:39393466 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
decreases expression
EXP
ISO
[NACHRA8 protein co-treated with CHRNB2 protein] affects the susceptibility to imidacloprid; imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; imidacloprid binds to [CHRNA4 protein co-treated with CHRNB2 protein]; imidacloprid binds to [NACHRALPHA1 protein co-treated with CHRNB2 protein]; imidacloprid binds to [NACHRALPHA2 protein co-treated with CHRNB2 protein]; imidacloprid binds to [NACHRALPHA3 protein co-treated with CHRNB2 protein]; imidacloprid results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]; imidacloprid results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]; imidacloprid results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]; imidacloprid results in increased activity of [NACHRALPHA1 protein co-treated with NACHRALPHA2 protein co-treated with CHRNB2 protein]; imidacloprid results in increased activity of [NACHRALPHA2 protein co-treated with CHRNB2 protein]; LYNX1 protein promotes the reaction [imidacloprid results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; LYPD1 protein promotes the reaction [imidacloprid results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]
imidacloprid results in decreased expression of CHRNB2 mRNA
imidacloprid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; imidacloprid results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:10377228 PMID:10728888 PMID:16291090 PMID:16981889 PMID:18824080 More... NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO imidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; imidacloprid results in increased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:34628512 NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Cidea cell death-inducing DFFA-like effector a multiple interactions ISO [imidacloprid co-treated with Dietary Fats] results in increased expression of CIDEA mRNA CTD PMID:33487623 NCBI chr18:63,164,817...63,190,384
Ensembl chr18:60,894,874...60,920,481
JBrowse link
G Cirbp cold inducible RNA binding protein multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CIRBP mRNA CTD PMID:33854195 NCBI chr 7:10,184,515...10,189,623
Ensembl chr 7:9,424,178...9,538,818
JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CLCF1 mRNA CTD PMID:33854195 NCBI chr 1:210,937,763...210,947,064
Ensembl chr 1:201,507,859...201,517,605
JBrowse link
G Cldn1 claudin 1 decreases expression EXP imidacloprid results in decreased expression of CLDN1 mRNA CTD PMID:27792329 NCBI chr11:87,926,376...87,941,533
Ensembl chr11:74,421,569...74,436,724
JBrowse link
G Clu clusterin multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CLU mRNA CTD PMID:33854195 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cndp2 carnosine dipeptidase 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CNDP2 mRNA CTD PMID:33854195 NCBI chr18:80,314,799...80,331,900
Ensembl chr18:78,039,932...78,056,922
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CPT2 mRNA CTD PMID:33854195 NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:122,664,677...122,682,095
JBrowse link
G Crb3 crumbs cell polarity complex component 3 increases expression EXP imidacloprid results in increased expression of CRB3 mRNA CTD PMID:27782041 NCBI chr 9:1,898,531...1,903,860
Ensembl chr 9:1,896,623...1,903,859
JBrowse link
G Cry1 cryptochrome circadian regulator 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CRY1 mRNA CTD PMID:33854195 NCBI chr 7:20,417,526...20,481,791
Ensembl chr 7:18,529,823...18,594,091
JBrowse link
G Cspp1 centrosome and spindle pole associated protein 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CSPP1 mRNA CTD PMID:33854195 NCBI chr 5:9,077,161...9,192,402
Ensembl chr 5:9,077,161...9,193,377
JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CSRNP1 mRNA CTD PMID:33854195 NCBI chr 8:128,582,364...128,594,163
Ensembl chr 8:119,704,713...119,718,183
JBrowse link
G Cth cystathionine gamma-lyase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of CTH gene CTD PMID:33854195 NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Ctnnal1 catenin alpha-like 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CTNNAL1 mRNA CTD PMID:33854195 NCBI chr 5:76,309,546...76,375,869
Ensembl chr 5:71,514,340...71,569,431
JBrowse link
G Ctnnd1 catenin delta 1 increases expression EXP imidacloprid results in increased expression of CTNND1 mRNA CTD PMID:27792329 NCBI chr 3:90,090,025...90,141,247
Ensembl chr 3:69,683,313...69,734,516
JBrowse link
G Cux2 cut-like homeobox 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CUX2 mRNA CTD PMID:33854195 NCBI chr12:40,168,402...40,368,303
Ensembl chr12:34,520,959...34,705,806
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
multiple interactions
ISO
EXP
imidacloprid results in decreased expression of CYP11A1 mRNA
Thymol inhibits the reaction [imidacloprid results in decreased expression of CYP11A1 mRNA]
CTD PMID:31780179 PMID:34171690 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression
multiple interactions
EXP
ISO
imidacloprid results in decreased expression of CYP17A1 mRNA
Thymol inhibits the reaction [imidacloprid results in decreased expression of CYP17A1 mRNA]
CTD PMID:27782041 PMID:31780179 PMID:34171690 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity
decreases expression
multiple interactions
affects expression
ISO
EXP
imidacloprid results in increased activity of CYP19A1 protein
imidacloprid results in decreased expression of CYP19A1 mRNA
Thymol inhibits the reaction [imidacloprid results in decreased expression of CYP19A1 mRNA]
imidacloprid affects the expression of CYP19A1 mRNA
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione affects the reaction [imidacloprid affects the expression of CYP19A1 mRNA]
CTD PMID:28750898 PMID:29701941 PMID:34171690 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO imidacloprid results in increased expression of CYP2B10 mRNA CTD PMID:36320626 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CYP2C22 mRNA CTD PMID:33854195 NCBI chr 1:238,991,698...239,031,323
Ensembl chr 1:238,991,610...239,021,738
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP imidacloprid results in increased expression of CYP2E1 mRNA CTD PMID:37632782 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [NADP co-treated with CYP3A4 protein] results in increased activity of imidacloprid analog CTD PMID:16153789 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CYP4A1 mRNA CTD PMID:33854195 NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of CYP4F1 mRNA CTD PMID:33854195 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases expression EXP imidacloprid results in increased expression of CYP4F18 mRNA CTD PMID:37632782 NCBI chr16:17,797,558...17,838,958
Ensembl chr16:17,707,317...17,804,940
JBrowse link
G Cytip cytohesin 1 interacting protein multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of CYTIP mRNA CTD PMID:33854195 NCBI chr 3:63,106,895...63,183,769
Ensembl chr 3:42,698,768...42,725,993
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of DBP mRNA CTD PMID:33854195 NCBI chr 1:105,312,256...105,317,205
Ensembl chr 1:96,175,440...96,180,745
JBrowse link
G Dclre1c DNA cross-link repair 1C multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of DCLRE1C mRNA CTD PMID:33854195 NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186
JBrowse link
G Ddx20 DEAD-box helicase 20 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of DDX20 mRNA CTD PMID:33854195 NCBI chr 2:195,847,105...195,859,989
Ensembl chr 2:193,158,823...193,166,774
JBrowse link
G Ddx5 DEAD-box helicase 5 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of DDX5 mRNA CTD PMID:33854195 NCBI chr10:92,224,393...92,231,928
Ensembl chr10:91,723,508...91,732,283
JBrowse link
G Dffb DNA fragmentation factor subunit beta multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of DFFB mRNA CTD PMID:33854195 NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:164,522,463...164,534,628
JBrowse link
G Dlg2 discs large MAGUK scaffold protein 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of DLG2 gene CTD PMID:33854195 NCBI chr 1:153,864,545...155,916,238
Ensembl chr 1:144,451,472...146,499,475
JBrowse link
G Dll1 delta like canonical Notch ligand 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of DLL1 mRNA CTD PMID:33854195 NCBI chr 1:64,985,161...64,993,274
Ensembl chr 1:56,312,066...56,320,179
JBrowse link
G Dmrt3 doublesex and mab-3 related transcription factor 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of DMRT3 gene CTD PMID:33854195 NCBI chr 1:223,244,340...223,264,254
Ensembl chr 1:223,248,747...223,262,530
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of DNAJB1 mRNA CTD PMID:33854195 NCBI chr19:41,427,453...41,431,141
Ensembl chr19:24,522,717...24,526,458
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of DNAJB9 mRNA CTD PMID:33854195 NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:61,269,913...61,275,063
JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of DPP4 mRNA CTD PMID:33854195 NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:46,962,243...47,043,901
JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 decreases expression EXP imidacloprid results in decreased expression of DPYSL3 mRNA CTD PMID:39002876 NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of DUSP1 mRNA CTD PMID:33854195 NCBI chr10:17,184,853...17,187,646 JBrowse link
G Dusp5 dual specificity phosphatase 5 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of DUSP5 gene CTD PMID:33854195 NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of DUSP6 mRNA CTD PMID:33854195 NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Dzip1l DAZ interacting zinc finger protein 1-like multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of DZIP1L gene CTD PMID:33854195 NCBI chr 8:109,067,466...109,108,390
Ensembl chr 8:100,194,999...100,228,988
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 multiple interactions ISO [imidacloprid co-treated with Dietary Fats] results in increased expression of ELOVL6 mRNA CTD PMID:33487623 NCBI chr 2:220,738,095...220,845,528
Ensembl chr 2:218,063,804...218,171,186
JBrowse link
G Emilin1 elastin microfibril interfacer 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of EMILIN1 mRNA CTD PMID:33854195 NCBI chr 6:31,175,919...31,183,657
Ensembl chr 6:25,445,298...25,463,698
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ENPP3 mRNA CTD PMID:33854195 NCBI chr 1:22,382,717...22,454,324
Ensembl chr 1:20,563,697...20,635,041
JBrowse link
G Epb41l3 erythrocyte membrane protein band 4.1-like 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of EPB41L3 gene CTD PMID:33854195 NCBI chr 9:116,502,864...116,707,274
Ensembl chr 9:109,016,113...109,260,607
JBrowse link
G Epm2aip1 EPM2A interacting protein 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of EPM2AIP1 mRNA CTD PMID:33854195 NCBI chr 8:120,112,265...120,119,613
Ensembl chr 8:111,233,826...111,241,871
JBrowse link
G Erf Ets2 repressor factor multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of ERF mRNA CTD PMID:33854195 NCBI chr 1:89,957,760...89,966,213
Ensembl chr 1:80,829,935...80,838,388
JBrowse link
G Esd esterase D multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ESD mRNA CTD PMID:33854195 NCBI chr15:56,453,082...56,472,582
Ensembl chr15:50,043,632...50,063,144
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO imidacloprid results in increased expression of ESR1 mRNA CTD PMID:35457321 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 affects expression ISO imidacloprid affects the expression of ESR2 mRNA CTD PMID:35457321 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 increases expression EXP imidacloprid results in increased expression of F2RL2 mRNA CTD PMID:27782041 NCBI chr 2:28,706,766...28,711,808
Ensembl chr 2:26,972,054...26,977,098
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [imidacloprid co-treated with Dietary Fats] results in decreased expression of FABP4 mRNA CTD PMID:33487623 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fam135a family with sequence similarity 135, member A multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of FAM135A mRNA CTD PMID:33854195 NCBI chr 9:26,420,116...26,500,803
Ensembl chr 9:26,420,528...26,500,717
JBrowse link
G Fam177a1 family with sequence similarity 177, member A1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of FAM177A1 gene CTD PMID:33854195 NCBI chr 6:72,632,628...72,647,553
Ensembl chr 6:72,632,623...72,647,553
JBrowse link
G Fam204a family with sequence similarity 204, member A multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of FAM204A mRNA CTD PMID:33854195 NCBI chr 1:269,323,473...269,352,772
Ensembl chr 1:259,337,709...259,367,077
JBrowse link
G Fam53a family with sequence similarity 53, member A multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of FAM53A gene CTD PMID:33854195 NCBI chr14:77,088,178...77,124,395
Ensembl chr14:77,090,723...77,124,395
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [imidacloprid co-treated with Dietary Fats] results in increased expression of FAS mRNA CTD PMID:33487623 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Ficd FIC domain protein adenylyltransferase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of FICD mRNA CTD PMID:33854195 NCBI chr12:42,889,195...42,894,090
Ensembl chr12:42,889,194...42,894,070
JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of FKBP4 mRNA CTD PMID:33854195 NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of FKBP5 gene CTD PMID:33854195 NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,457,216...6,541,674
JBrowse link
G Fmn1 formin 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of FMN1 mRNA CTD PMID:33854195 NCBI chr 3:120,555,445...120,939,978
Ensembl chr 3:100,134,549...100,479,220
JBrowse link
G Frmd4b FERM domain containing 4B multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of FRMD4B mRNA CTD PMID:33854195 NCBI chr 4:131,452,361...131,778,734
Ensembl chr 4:129,895,708...130,084,197
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
increases expression
EXP Thymol inhibits the reaction [imidacloprid results in increased expression of FSHB protein] CTD PMID:34171690 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Fzd6 frizzled class receptor 6 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of FZD6 mRNA CTD PMID:33854195 NCBI chr 7:71,939,916...71,971,685
Ensembl chr 7:70,055,068...70,086,776
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of GADD45G mRNA CTD PMID:33854195 NCBI chr17:13,528,606...13,530,351
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Galnt7 polypeptide N-acetylgalactosaminyltransferase 7 increases expression EXP imidacloprid results in increased expression of GALNT7 mRNA CTD PMID:27782041 NCBI chr16:37,589,368...37,713,911
Ensembl chr16:32,578,690...32,702,690
JBrowse link
G Gatd3a glutamine amidotransferase class 1 domain containing 3A multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of GATD3A mRNA CTD PMID:33854195 NCBI chr20:10,514,793...10,522,894
Ensembl chr20:10,514,744...10,522,885
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of GDF15 mRNA CTD PMID:33854195 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP imidacloprid results in increased expression of GFAP mRNA; imidacloprid results in increased expression of GFAP protein CTD PMID:18080902 PMID:39002876 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gin1 gypsy retrotransposon integrase 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of GIN1 mRNA CTD PMID:33854195 NCBI chr 9:98,293,596...98,315,155
Ensembl chr 9:98,293,597...98,315,848
JBrowse link
G Git2 GIT ArfGAP 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of GIT2 mRNA CTD PMID:33854195 NCBI chr12:41,829,717...41,872,621
Ensembl chr12:41,829,730...41,871,097
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression EXP imidacloprid results in decreased expression of GJA1 mRNA CTD PMID:27792329 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of GLB1 mRNA CTD PMID:33854195 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
JBrowse link
G Gnpda2 glucosamine-6-phosphate deaminase 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of GNPDA2 mRNA CTD PMID:33854195 NCBI chr14:38,520,663...38,538,713
Ensembl chr14:38,520,705...38,538,713
JBrowse link
G Gprasp3 G protein-coupled receptor associated sorting protein family member 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of GPRASP3 mRNA CTD PMID:33854195 NCBI chr  X:103,639,366...103,644,561
Ensembl chr  X:98,817,593...98,854,545
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
increases expression
EXP
ISO
imidacloprid results in increased activity of GPT protein
[imidacloprid co-treated with Dietary Fats] results in increased expression of GPT protein
imidacloprid results in increased expression of GPT protein
[imidacloprid co-treated with fipronil co-treated with Glyphosate] results in increased activity of and results in increased secretion of GPT protein
[imidacloprid co-treated with sodium arsenate] results in increased activity of GPT protein
CTD PMID:30033815 PMID:33487623 PMID:34993831 PMID:35850439 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP imidacloprid results in decreased expression of GPX1 mRNA CTD PMID:39002876 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression EXP imidacloprid results in increased expression of GPX4 mRNA CTD PMID:39002876 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gramd1a GRAM domain containing 1A multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of GRAMD1A mRNA CTD PMID:33854195 NCBI chr 1:86,367,001...86,393,348
Ensembl chr 1:86,367,001...86,393,336
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of GRIA1 gene CTD PMID:33854195 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Grina glutamate ionotropic receptor NMDA type subunit associated protein 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of GRINA mRNA CTD PMID:33854195 NCBI chr 7:109,842,870...109,846,048
Ensembl chr 7:107,962,207...107,965,366
JBrowse link
G Gsdma gasdermin A multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of GSDMA gene CTD PMID:33854195 NCBI chr10:84,110,590...84,135,804
Ensembl chr10:83,627,051...83,639,543
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
EXP imidacloprid promotes the reaction [sodium arsenate results in decreased activity of GSR protein]; sodium arsenate promotes the reaction [imidacloprid results in decreased activity of GSR protein] CTD PMID:30033815 PMID:30456172 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of GSTK1 mRNA CTD PMID:33854195 NCBI chr 4:72,085,532...72,089,934
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Hao1 hydroxyacid oxidase 1 decreases expression EXP imidacloprid results in decreased expression of HAO1 mRNA CTD PMID:27782041 NCBI chr 3:142,102,873...142,281,527
Ensembl chr 3:121,771,836...121,828,721
JBrowse link
G Hapstr2 HUWE1 associated protein modifying stress responses 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of HAPSTR2 gene CTD PMID:33854195 NCBI chr  X:138,922,089...138,924,124
Ensembl chr  X:138,922,100...138,922,918
JBrowse link
G Hars1 histidyl-tRNA synthetase 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of HARS1 mRNA CTD PMID:33854195 NCBI chr18:28,655,669...28,672,712
Ensembl chr18:28,381,655...28,398,740
JBrowse link
G Hebp1 heme binding protein 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of HEBP1 mRNA CTD PMID:33854195 NCBI chr 4:169,705,665...169,735,199
Ensembl chr 4:167,974,319...168,003,854
JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of HES1 mRNA CTD PMID:33854195 NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Hjv hemojuvelin BMP co-receptor decreases expression EXP imidacloprid results in decreased expression of HJV mRNA CTD PMID:27782041 NCBI chr 2:186,754,801...186,758,708
Ensembl chr 2:184,065,970...184,069,850
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO imidacloprid results in decreased expression of HMGCR mRNA CTD PMID:31780179 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
affects expression
EXP imidacloprid results in increased expression of HMOX1 mRNA
imidacloprid affects the expression of HMOX1 mRNA
CTD PMID:34993831 PMID:39002876 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hs3st3b1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of HS3ST3B1 mRNA CTD PMID:33854195 NCBI chr10:49,060,693...49,093,185
Ensembl chr10:48,561,473...48,593,970
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of HSD11B2 mRNA CTD PMID:33854195 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of HSD17B10 mRNA CTD PMID:33854195 NCBI chr  X:24,568,551...24,571,012
Ensembl chr  X:21,089,122...21,109,488
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of HSD17B2 mRNA CTD PMID:33854195 NCBI chr19:62,662,320...62,733,944
Ensembl chr19:45,753,574...45,825,202
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions
decreases expression
EXP Thymol inhibits the reaction [imidacloprid results in decreased expression of HSD17B3 mRNA] CTD PMID:34171690 NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,027,229...1,058,554
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases expression EXP imidacloprid results in decreased expression of HSD3B2 mRNA CTD PMID:27914857 NCBI chr 2:188,784,614...188,812,535
Ensembl chr 2:186,095,897...186,101,852
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression ISO imidacloprid results in decreased expression of HSP90B1 protein CTD PMID:16884889 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of HSPA1B mRNA CTD PMID:33854195 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO imidacloprid results in decreased expression of HSPA5 protein CTD PMID:16884889 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression ISO imidacloprid results in decreased expression of HSPB1 protein CTD PMID:16884889 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Hspb7 heat shock protein family B (small) member 7 decreases expression EXP imidacloprid results in decreased expression of HSPB7 mRNA CTD PMID:27782041 NCBI chr 5:159,010,759...159,014,245
Ensembl chr 5:153,727,588...153,731,266
JBrowse link
G Hspbp1 HSPA (Hsp70) binding protein 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of HSPBP1 mRNA CTD PMID:33854195 NCBI chr 1:69,165,394...69,189,062
Ensembl chr 1:69,165,572...69,244,593
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases expression EXP imidacloprid results in increased expression of HTR2C mRNA CTD PMID:27782041 NCBI chr  X:115,453,190...115,682,325
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Ier3 immediate early response 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of IER3 mRNA CTD PMID:33854195 NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Ifna12l interferon alpha 12 like multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of IFNA12L gene CTD PMID:33854195 NCBI chr 5:108,592,149...108,593,214
Ensembl chr 5:103,476,657...103,477,211
Ensembl chr 5:103,476,657...103,477,211
Ensembl chr 5:103,476,657...103,477,211
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of IGFBP1 mRNA CTD PMID:33854195 NCBI chr14:86,261,277...86,266,344
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Igkv2-112l2 immunoglobulin kappa variable 2-112 like 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of IGKV2-112L2 gene CTD PMID:33854195 NCBI chr 4:102,208,069...102,208,647
Ensembl chr 4:102,208,044...102,208,785
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
EXP Plant Extracts inhibits the reaction [imidacloprid results in decreased expression of IL10 mRNA] CTD PMID:35398170 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP
ISO
imidacloprid results in increased expression of IL1B mRNA
[imidacloprid co-treated with Dietary Fats] results in decreased expression of IL1B mRNA
Plant Extracts inhibits the reaction [imidacloprid results in increased expression of IL1B mRNA]
CTD PMID:33487623 PMID:35398170 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 increases expression EXP imidacloprid results in increased expression of IL4 mRNA CTD PMID:39002876 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions
affects expression
increases expression
EXP
ISO
Plant Extracts inhibits the reaction [imidacloprid results in increased expression of IL6 mRNA]
imidacloprid affects the expression of IL6 mRNA
[imidacloprid co-treated with Dietary Fats] results in decreased expression of IL6 mRNA
CTD PMID:33487623 PMID:35398170 PMID:39002876 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of INPP5F mRNA CTD PMID:33854195 NCBI chr 1:192,620,891...192,700,681
Ensembl chr 1:183,190,480...183,270,276
JBrowse link
G Ins1 insulin 1 decreases expression
increases secretion
multiple interactions
EXP
ISO
imidacloprid results in decreased expression of INS1 protein
imidacloprid results in increased secretion of INS1 protein
Dietary Fats promotes the reaction [imidacloprid results in increased secretion of INS1 protein]; imidacloprid promotes the reaction [Dietary Fats results in increased secretion of INS1 protein]
CTD PMID:27960282 PMID:28850943 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Iqcb1 IQ motif containing B1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of IQCB1 mRNA CTD PMID:33854195 NCBI chr11:77,410,986...77,465,540
Ensembl chr11:63,905,590...63,960,093
JBrowse link
G Irf2bp2 interferon regulatory factor 2 binding protein 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of IRF2BP2 mRNA CTD PMID:33854195 NCBI chr19:71,456,689...71,462,368
Ensembl chr19:54,560,128...54,566,642
JBrowse link
G Itprip inositol 1,4,5-trisphosphate receptor interacting protein multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ITPRIP mRNA CTD PMID:33854195 NCBI chr 1:246,762,804...246,786,379
Ensembl chr 1:246,762,472...246,786,408
JBrowse link
G Itpripl1 ITPRIP like 1 decreases expression EXP imidacloprid results in decreased expression of ITPRIPL1 mRNA CTD PMID:27782041 NCBI chr 3:114,403,123...114,407,917
Ensembl chr 3:114,402,270...114,414,497
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of JUNB mRNA CTD PMID:33854195 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Katnip katanin interacting protein multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of KATNIP gene CTD PMID:33854195 NCBI chr 1:189,700,838...189,867,402
Ensembl chr 1:180,269,929...180,436,766
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression EXP imidacloprid results in decreased expression of KEAP1 mRNA CTD PMID:34993831 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Khdc4 KH domain containing 4, pre-mRNA splicing factor multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of KHDC4 mRNA CTD PMID:33854195 NCBI chr 2:174,149,059...174,177,816
Ensembl chr 2:174,149,141...174,177,504
JBrowse link
G Klf10 KLF transcription factor 10 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of KLF10 mRNA CTD PMID:33854195 NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:69,465,619...69,473,994
JBrowse link
G Klf2 KLF transcription factor 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of KLF2 mRNA CTD PMID:33854195 NCBI chr16:17,555,136...17,557,768
Ensembl chr16:17,514,552...17,523,944
JBrowse link
G Klhl10 kelch-like family member 10 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of KLHL10 gene CTD PMID:33854195 NCBI chr10:85,376,442...85,392,720
Ensembl chr10:85,376,442...85,392,720
JBrowse link
G Klk1 kallikrein 1 decreases expression EXP imidacloprid results in decreased expression of KLK1 mRNA CTD PMID:27782041 NCBI chr 1:103,779,152...103,783,270
Ensembl chr 1:94,642,687...94,646,754
JBrowse link
G Krt5 keratin 5 decreases expression EXP imidacloprid results in decreased expression of KRT5 mRNA CTD PMID:27782041 NCBI chr 7:134,724,840...134,730,569
Ensembl chr 7:132,846,136...132,851,850
JBrowse link
G Lep leptin multiple interactions
increases secretion
ISO Dietary Fats promotes the reaction [imidacloprid results in increased secretion of LEP protein]; imidacloprid promotes the reaction [Dietary Fats results in increased secretion of LEP protein] CTD PMID:27960282 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lgalsl galectin-like multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of LGALSL mRNA CTD PMID:33854195 NCBI chr14:99,198,340...99,205,846
Ensembl chr14:94,996,990...95,004,980
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions
increases expression
EXP Thymol inhibits the reaction [imidacloprid results in increased expression of LHB protein] CTD PMID:34171690 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lhx2 LIM homeobox 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of LHX2 gene CTD PMID:33854195 NCBI chr 3:42,523,345...42,553,646
Ensembl chr 3:22,126,007...22,143,908
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO LIF protein affects the reaction [imidacloprid affects the methylation of APC promoter]; LIF protein affects the reaction [imidacloprid affects the methylation of CDH1 promoter]; LIF protein affects the reaction [imidacloprid affects the methylation of CDKN2A promoter]; LIF protein affects the reaction [imidacloprid affects the methylation of MLH1 promoter]; LIF protein affects the reaction [imidacloprid affects the methylation of RARB promoter]; LIF protein affects the reaction [imidacloprid affects the methylation of TIMP3 promoter] CTD PMID:33865946 NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Lipe lipase E, hormone sensitive type increases expression ISO imidacloprid results in increased expression of LIPE mRNA CTD PMID:33487623 NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:80,965,627...80,984,310
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of LITAF mRNA CTD PMID:33854195 NCBI chr10:5,163,258...5,199,930
Ensembl chr10:4,625,552...4,692,763
JBrowse link
G Lnx2 ligand of numb-protein X 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of LNX2 mRNA CTD PMID:33854195 NCBI chr12:8,005,202...8,070,494
Ensembl chr12:8,005,227...8,070,494
JBrowse link
G Loxl3 lysyl oxidase-like 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of LOXL3 gene CTD PMID:33854195 NCBI chr 4:117,098,358...117,114,673
Ensembl chr 4:115,540,685...115,557,466
JBrowse link
G Lpcat1 lysophosphatidylcholine acyltransferase 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of LPCAT1 gene CTD PMID:33854195 NCBI chr 1:29,766,070...29,816,401
Ensembl chr 1:29,766,071...29,816,401
JBrowse link
G Lpgat1 lysophosphatidylglycerol acyltransferase 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of LPGAT1 gene CTD PMID:33854195 NCBI chr13:103,294,622...103,365,372
Ensembl chr13:103,294,528...103,362,333
JBrowse link
G Lpin3 lipin 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of LPIN3 mRNA CTD PMID:33854195 NCBI chr 3:169,953,479...169,978,034
Ensembl chr 3:149,534,051...149,558,327
JBrowse link
G Lta4h leukotriene A4 hydrolase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of LTA4H mRNA CTD PMID:33854195 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
JBrowse link
G Lurap1l leucine rich adaptor protein 1-like multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of LURAP1L gene CTD PMID:33854195 NCBI chr 5:100,402,921...100,455,479
Ensembl chr 5:95,362,005...95,409,438
JBrowse link
G Lynx1 Ly6/neurotoxin 1 multiple interactions EXP LYNX1 protein promotes the reaction [imidacloprid results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]] CTD PMID:19619141 NCBI chr 7:108,521,783...108,527,012
Ensembl chr 7:106,632,797...106,638,023
JBrowse link
G Lypd1 Ly6/Plaur domain containing 1 multiple interactions EXP LYPD1 protein promotes the reaction [imidacloprid results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]] CTD PMID:19619141 NCBI chr13:39,874,937...39,922,385
Ensembl chr13:37,326,464...37,368,493
JBrowse link
G Lyz2 lysozyme 2 multiple interactions
decreases activity
EXP Plant Extracts inhibits the reaction [imidacloprid results in decreased activity of LYZ protein] CTD PMID:35398170 NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Magel2 MAGE family member L2 increases expression EXP imidacloprid results in increased expression of MAGEL2 mRNA CTD PMID:27782041 NCBI chr 1:125,292,033...125,296,575
Ensembl chr 1:115,880,474...115,884,250
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO imidacloprid results in increased phosphorylation of MAPK1 protein CTD PMID:12460746 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO imidacloprid results in increased phosphorylation of MAPK3 protein CTD PMID:12460746 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression EXP imidacloprid results in increased expression of MAPK8 mRNA CTD PMID:34993831 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of MAPKAPK2 mRNA CTD PMID:33854195 NCBI chr13:45,066,027...45,112,326
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Marf1 meiosis regulator and mRNA stability factor 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of MARF1 mRNA CTD PMID:33854195 NCBI chr10:888,053...932,760
Ensembl chr10:888,076...932,753
JBrowse link
G Mb myoglobin decreases expression EXP imidacloprid results in decreased expression of MB mRNA CTD PMID:27782041 NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
G Med12l mediator complex subunit 12L multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of MED12L mRNA CTD PMID:33854195 NCBI chr 2:145,403,318...145,726,317
Ensembl chr 2:143,252,139...143,573,741
JBrowse link
G Mettl14 methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of METTL14 mRNA CTD PMID:33854195 NCBI chr 2:214,215,165...214,231,412
Ensembl chr 2:211,530,602...211,546,821
JBrowse link
G Mfap5 microfibril associated protein 5 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of MFAP5 gene CTD PMID:33854195 NCBI chr 4:155,727,925...155,750,458
Ensembl chr 4:155,727,925...155,750,458
JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of MIF mRNA CTD PMID:33854195 NCBI chr20:12,767,138...12,791,222
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504
JBrowse link
G Mir122 microRNA 122 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of MIR122 mRNA CTD PMID:34626815 NCBI chr18:61,028,817...61,028,901 JBrowse link
G Mir130a microRNA 130a multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of MIR130A mRNA CTD PMID:34626815 NCBI chr 3:90,229,228...90,229,315
Ensembl chr 3:69,822,542...69,822,629
JBrowse link
G Mir146a microRNA 146a multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of MIR146A mRNA CTD PMID:34626815 NCBI chr10:28,349,996...28,350,090
Ensembl chr10:27,848,516...27,848,610
JBrowse link
G Mir193 microRNA 193 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of MIR193 mRNA CTD PMID:34626815 NCBI chr10:64,672,354...64,672,439 JBrowse link
G Mir22 microRNA 22 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of MIR22 mRNA CTD PMID:34626815 NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,307,039...60,307,133
JBrowse link
G Mir32 microRNA 32 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of MIR32 mRNA CTD PMID:34626815 NCBI chr 5:71,596,083...71,596,152
Ensembl chr 5:71,596,083...71,596,152
JBrowse link
G Mir33 microRNA 33 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of MIR33 mRNA CTD PMID:34626815 NCBI chr 7:115,593,952...115,594,020
Ensembl chr 7:113,713,855...113,713,923
JBrowse link
G Mir486 microRNA 486 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of MIR486 mRNA CTD PMID:34626815
G Mlh1 mutL homolog 1 multiple interactions
affects methylation
ISO LIF protein affects the reaction [imidacloprid affects the methylation of MLH1 promoter] CTD PMID:33865946 NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Mlxipl MLX interacting protein-like increases expression ISO imidacloprid results in increased expression of MLXIPL mRNA CTD PMID:33487623 NCBI chr12:27,178,158...27,213,675
Ensembl chr12:21,543,576...21,577,112
JBrowse link
G Mlycd malonyl-CoA decarboxylase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of MLYCD mRNA CTD PMID:33854195 NCBI chr19:64,356,582...64,372,447
Ensembl chr19:47,447,970...47,463,793
JBrowse link
G Mocs2 molybdenum cofactor synthesis 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of MOCS2 mRNA CTD PMID:33854195 NCBI chr 2:46,504,588...46,516,327
Ensembl chr 2:46,504,588...46,516,324
JBrowse link
G Morc3 MORC family CW-type zinc finger 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of MORC3 mRNA CTD PMID:33854195 NCBI chr11:46,621,575...46,664,315
Ensembl chr11:33,152,025...33,194,646
JBrowse link
G Mpo myeloperoxidase increases expression EXP imidacloprid results in increased expression of MPO protein CTD PMID:37648049 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mrgbp MRG domain binding protein multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of MRGBP mRNA CTD PMID:33854195 NCBI chr 3:188,074,695...188,078,162
Ensembl chr 3:167,697,185...167,700,592
JBrowse link
G Mrnip MRN complex interacting protein multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of MRNIP mRNA CTD PMID:33854195 NCBI chr10:34,501,359...34,525,474
Ensembl chr10:34,501,384...34,525,469
JBrowse link
G Mrpl44 mitochondrial ribosomal protein L44 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of MRPL44 mRNA CTD PMID:33854195 NCBI chr 9:81,106,658...81,111,709
Ensembl chr 9:81,106,655...81,112,812
JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of MRPS18B mRNA CTD PMID:33854195 NCBI chr20:2,838,174...2,844,260
Ensembl chr20:2,838,030...2,844,260
JBrowse link
G Mt1 metallothionein 1 increases expression EXP imidacloprid results in increased expression of MT1 mRNA CTD PMID:39002876 NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049
JBrowse link
G Mt2 metallothionein 2 increases expression EXP imidacloprid results in increased expression of MT2A mRNA CTD PMID:39002876 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of MTARC1 mRNA CTD PMID:33854195 NCBI chr13:98,854,235...98,894,208
Ensembl chr13:96,339,757...96,397,796
JBrowse link
G Mybpc2 myosin binding protein C2 increases expression EXP imidacloprid results in increased expression of MYBPC2 mRNA CTD PMID:27782041 NCBI chr 1:104,130,642...104,154,101
Ensembl chr 1:94,994,104...95,017,584
JBrowse link
G Myo10 myosin X multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of MYO10 mRNA CTD PMID:33854195 NCBI chr 2:76,100,989...76,305,619
Ensembl chr 2:76,100,987...76,303,030
JBrowse link
G Mypn myopalladin decreases expression EXP imidacloprid results in decreased expression of MYPN mRNA CTD PMID:27782041 NCBI chr20:25,435,554...25,521,149
Ensembl chr20:25,436,843...25,522,443
JBrowse link
G N4bp2l2 NEDD4 binding protein 2-like 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of N4BP2L2 mRNA CTD PMID:33854195 NCBI chr12:137,342...200,292
Ensembl chr12:103,590...197,784
JBrowse link
G Nae1 NEDD8 activating enzyme E1 subunit 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of NAE1 mRNA CTD PMID:33854195 NCBI chr19:452,462...478,591
Ensembl chr19:446,000...472,371
JBrowse link
G Ndufaf2 NADH:ubiquinone oxidoreductase complex assembly factor 2 decreases expression EXP imidacloprid results in decreased expression of NDUFAF2 mRNA CTD PMID:27782041 NCBI chr 2:41,269,141...41,380,895
Ensembl chr 2:39,535,689...39,647,316
JBrowse link
G Ndufb11 NADH:ubiquinone oxidoreductase subunit B11 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of NDUFB11 gene CTD PMID:33854195 NCBI chr  X:4,126,317...4,128,575
Ensembl chr  X:1,572,785...1,575,062
JBrowse link
G Nes nestin decreases expression EXP imidacloprid results in decreased expression of NES mRNA CTD PMID:39002876 NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Neurog3 neurogenin 3 decreases expression EXP imidacloprid results in decreased expression of NEUROG3 mRNA CTD PMID:27782041 NCBI chr20:30,622,533...30,624,015
Ensembl chr20:30,079,780...30,081,262
JBrowse link
G Nfe2 nuclear factor, erythroid 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of NFE2 mRNA CTD PMID:33854195 NCBI chr 7:136,261,234...136,273,850
Ensembl chr 7:134,382,761...134,390,108
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects expression EXP imidacloprid affects the expression of NFE2L2 mRNA CTD PMID:39002876 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of NFIL3 mRNA CTD PMID:33854195 NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,280,484...12,295,858
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression EXP imidacloprid results in increased expression of NFKB1 mRNA CTD PMID:39002876 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of NR0B2 mRNA CTD PMID:33854195 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of NR1D1 mRNA CTD PMID:33854195 NCBI chr10:84,224,599...84,231,812
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of NR1D2 mRNA CTD PMID:33854195 NCBI chr15:9,955,034...9,981,329
Ensembl chr15:7,524,257...7,550,553
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression ISO imidacloprid results in increased expression of NR1I2 mRNA CTD PMID:33487623 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases abundance ISO NR1I3 results in decreased abundance of imidacloprid CTD PMID:36320626 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression EXP imidacloprid results in decreased expression of NR5A1 mRNA CTD PMID:27914857 NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:22,465,502...22,486,328
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression EXP imidacloprid results in increased expression of NTRK2 mRNA CTD PMID:39002876 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of NUCKS1 mRNA CTD PMID:33854195 NCBI chr13:45,897,275...45,926,491
Ensembl chr13:43,345,115...43,370,229
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like increases expression EXP imidacloprid results in increased expression of OASL mRNA CTD PMID:27782041 NCBI chr12:47,343,551...47,356,509
Ensembl chr12:41,682,900...41,695,641
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression EXP imidacloprid results in increased expression of OGG1 mRNA CTD PMID:27914857 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Olr943 olfactory receptor 943 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of OLR943 gene CTD PMID:33854195 NCBI chr 7:3,389,336...3,390,274
Ensembl chr 7:3,388,200...3,392,130
JBrowse link
G Oplah 5-oxoprolinase (ATP-hydrolysing) multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of OPLAH mRNA CTD PMID:33854195 NCBI chr 7:108,011,472...108,051,751
Ensembl chr 7:108,011,475...108,035,297
JBrowse link
G Orai3 ORAI calcium release-activated calcium modulator 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of ORAI3 gene CTD PMID:33854195 NCBI chr 1:191,811,671...191,816,530
Ensembl chr 1:182,344,293...182,386,052
JBrowse link
G Pabir1 PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of PABIR1 gene CTD PMID:33854195 NCBI chr 1:222,114,988...222,116,294
Ensembl chr 1:222,112,591...222,116,396
JBrowse link
G Parpbp PARP1 binding protein multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of PARPBP gene CTD PMID:33854195 NCBI chr 7:22,511,427...22,580,834
Ensembl chr 7:22,511,427...22,573,695
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression
multiple interactions
ISO imidacloprid results in increased expression of PCK2 mRNA
Dietary Fats promotes the reaction [imidacloprid results in increased expression of PCK2 mRNA]; imidacloprid promotes the reaction [Dietary Fats results in increased expression of PCK2 mRNA]
CTD PMID:27960282 NCBI chr15:32,997,853...33,006,691
Ensembl chr15:29,027,894...29,037,283
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
EXP Thymol inhibits the reaction [imidacloprid results in decreased expression of PCNA protein]
imidacloprid results in decreased expression of PCNA mRNA; imidacloprid results in decreased expression of PCNA protein
CTD PMID:34171690 PMID:39002876 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO imidacloprid results in increased expression of PDK4 mRNA CTD PMID:27960282 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Pdlim1 PDZ and LIM domain 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PDLIM1 mRNA CTD PMID:33854195 NCBI chr 1:248,991,818...249,040,409
Ensembl chr 1:239,042,385...239,091,076
JBrowse link
G Pdp1 pyruvate dehydrogenase phosphatase catalytic subunit 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of PDP1 mRNA CTD PMID:33854195 NCBI chr 5:30,245,699...30,252,494
Ensembl chr 5:25,446,272...25,455,217
JBrowse link
G Pdzd2 PDZ domain containing 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of PDZD2 gene CTD PMID:33854195 NCBI chr 2:61,384,614...61,770,516
Ensembl chr 2:61,386,381...61,770,524
JBrowse link
G Per1 period circadian regulator 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PER1 mRNA CTD PMID:33854195 NCBI chr10:54,299,002...54,313,804
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Per3 period circadian regulator 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of PER3 mRNA CTD PMID:33854195 NCBI chr 5:166,740,914...166,778,243
Ensembl chr 5:161,459,533...161,495,607
JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PGK1 mRNA CTD PMID:33854195 NCBI chr  X:75,336,988...75,352,962
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Pgr progesterone receptor affects expression ISO imidacloprid affects the expression of PGR mRNA CTD PMID:35457321 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of PIAS3 mRNA CTD PMID:33854195 NCBI chr 2:186,921,384...186,930,292
Ensembl chr 2:184,232,571...184,241,480
JBrowse link
G Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of PIP4P1 mRNA CTD PMID:33854195 NCBI chr15:26,620,399...26,624,369
Ensembl chr15:24,146,856...24,150,702
JBrowse link
G Pirb paired Ig-like receptor B multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of LILRB3 mRNA CTD PMID:33854195 NCBI chr 1:74,414,556...74,433,015
Ensembl chr 1:65,499,195...65,506,666
JBrowse link
G Plekhg5 pleckstrin homology and RhoGEF domain containing G5 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of PLEKHG5 mRNA CTD PMID:33854195 NCBI chr 5:162,577,999...162,621,518
Ensembl chr 5:162,578,071...162,621,513
JBrowse link
G Plk2 polo-like kinase 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of PLK2 mRNA CTD PMID:33854195 NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Plpp4 phospholipid phosphatase 4 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of PLPP4 gene CTD PMID:33854195 NCBI chr 1:183,829,794...183,959,319
Ensembl chr 1:183,830,409...183,959,319
JBrowse link
G Pmvk phosphomevalonate kinase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PMVK mRNA CTD PMID:33854195 NCBI chr 2:177,174,344...177,184,076
Ensembl chr 2:174,876,657...174,886,364
JBrowse link
G Pnkd PNKD metallo-beta-lactamase domain containing multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PNKD mRNA CTD PMID:33854195 NCBI chr 9:83,317,757...83,386,263
Ensembl chr 9:75,867,468...75,937,124
JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase multiple interactions
increases expression
EXP imidacloprid promotes the reaction [Nicotine results in increased expression of PNMT protein]
imidacloprid results in increased expression of PNMT protein
CTD PMID:29246838 NCBI chr10:83,881,211...83,882,849
Ensembl chr10:83,384,923...83,386,556
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 increases expression ISO imidacloprid results in increased expression of PNPLA2 mRNA CTD PMID:33487623 NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:196,552,723...196,557,805
JBrowse link
G Pnrc1 proline-rich nuclear receptor coactivator 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PNRC1 mRNA CTD PMID:33854195 NCBI chr 5:52,443,400...52,489,303
Ensembl chr 5:47,647,071...47,650,161
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of POR gene CTD PMID:33854195 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
increases expression
ISO imidacloprid results in decreased expression of PPARA mRNA
imidacloprid results in increased expression of PPARA mRNA
CTD PMID:27960282 PMID:33487623 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PPARD mRNA CTD PMID:33854195 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression ISO imidacloprid results in decreased expression of PPARGC1A protein CTD PMID:27960282 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prdm15 PR/SET domain 15 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of PRDM15 mRNA CTD PMID:33854195 NCBI chr11:37,164,608...37,225,172
Ensembl chr11:37,165,575...37,222,207
JBrowse link
G Prelid2 PRELI domain containing 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PRELID2 mRNA CTD PMID:33854195 NCBI chr18:33,869,934...33,961,320
Ensembl chr18:33,873,599...33,961,225
JBrowse link
G Prelp proline and arginine rich end leucine rich repeat protein multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PRELP mRNA CTD PMID:33854195 NCBI chr13:45,368,407...45,391,480
Ensembl chr13:45,370,533...45,380,270
JBrowse link
G Prl prolactin multiple interactions ISO [mancozeb co-treated with imidacloprid] results in increased expression of PRL protein CTD PMID:24530807 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Proser2 proline and serine rich 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PROSER2 mRNA CTD PMID:33854195 NCBI chr17:77,061,371...77,096,788
Ensembl chr17:72,151,872...72,185,825
JBrowse link
G Prpf39 pre-mRNA processing factor 39 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of PRPF39 mRNA CTD PMID:33854195 NCBI chr 6:83,088,981...83,113,826
Ensembl chr 6:83,088,986...83,113,825
JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PSMC2 mRNA CTD PMID:33854195 NCBI chr 4:14,148,080...14,162,390
Ensembl chr 4:13,255,856...13,270,185
JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PSMC4 mRNA CTD PMID:33854195 NCBI chr 1:92,476,690...92,485,268
Ensembl chr 1:83,348,592...83,357,494
JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PSMC5 mRNA CTD PMID:33854195 NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,187,743...91,213,135
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP imidacloprid results in increased expression of PTGS2 mRNA CTD PMID:39002876 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptpa protein phosphatase 2 phosphatase activator multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PTPA mRNA CTD PMID:33854195 NCBI chr 3:13,689,742...13,720,287
Ensembl chr 3:13,689,741...13,722,549
JBrowse link
G Pus10 pseudouridine synthase 10 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of PUS10 mRNA CTD PMID:33854195 NCBI chr14:97,621,228...97,684,059
Ensembl chr14:97,621,391...97,684,046
JBrowse link
G Rabep1 rabaptin, RAB GTPase binding effector protein 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of RABEP1 mRNA CTD PMID:33854195 NCBI chr10:56,064,742...56,168,778
Ensembl chr10:55,566,185...55,665,973
JBrowse link
G Rabl2 RAB, member of RAS oncogene family like 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of RABL2 mRNA CTD PMID:33854195 NCBI chr 7:120,652,175...120,660,906
Ensembl chr 7:120,652,175...120,660,783
JBrowse link
G Ramac RNA guanine-7 methyltransferase activating subunit multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of RAMAC gene CTD PMID:33854195 NCBI chr 1:135,708,529...135,714,417
Ensembl chr 1:135,708,535...135,722,151
JBrowse link
G Rangap1 RAN GTPase activating protein 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of RANGAP1 mRNA CTD PMID:33854195 NCBI chr 7:113,224,695...113,250,441
Ensembl chr 7:113,224,703...113,250,438
JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions
affects methylation
ISO LIF protein affects the reaction [imidacloprid affects the methylation of RARB promoter] CTD PMID:33865946 NCBI chr15:10,837,252...11,482,037
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rars1 arginyl-tRNA synthetase 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of RARS1 mRNA CTD PMID:33854195 NCBI chr10:20,270,744...20,295,192
Ensembl chr10:20,270,483...20,295,196
JBrowse link
G Rbfox2 RNA binding fox-1 homolog 2 increases expression EXP imidacloprid results in increased expression of RBFOX2 mRNA CTD PMID:27782041 NCBI chr 7:110,691,230...110,934,901
Ensembl chr 7:108,810,628...109,054,691
JBrowse link
G Rbm14 RNA binding motif protein 14 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of RBM14 mRNA CTD PMID:33854195 NCBI chr 1:211,476,298...211,535,077
Ensembl chr 1:202,078,287...202,105,665
Ensembl chr 1:202,078,287...202,105,665
JBrowse link
G Rbm3 RNA binding motif protein 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of RBM3 mRNA CTD PMID:33854195 NCBI chr  X:17,020,863...17,024,341
Ensembl chr  X:14,348,910...14,353,580
JBrowse link
G Rbpms RNA binding protein, mRNA processing factor multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of RBPMS gene CTD PMID:33854195 NCBI chr16:58,239,370...58,395,424
Ensembl chr16:58,239,474...58,395,426
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression EXP imidacloprid results in increased expression of RELA protein CTD PMID:37648049 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Resf1 retroelement silencing factor 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of RESF1 mRNA CTD PMID:33854195 NCBI chr 4:184,057,165...184,093,374
Ensembl chr 4:182,335,454...182,362,054
JBrowse link
G Rev1 REV1, DNA directed polymerase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of REV1 mRNA CTD PMID:33854195 NCBI chr 9:47,773,907...47,847,554
Ensembl chr 9:40,278,101...40,351,576
JBrowse link
G Rfx7 regulatory factor X, 7 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of RFX7 mRNA CTD PMID:33854195 NCBI chr 8:73,254,051...73,339,209
Ensembl chr 8:73,254,051...73,339,209
JBrowse link
G Rgcc regulator of cell cycle multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of RGCC gene CTD PMID:33854195 NCBI chr15:61,071,574...61,084,408
Ensembl chr15:54,662,483...54,681,141
JBrowse link
G Rgs16 regulator of G-protein signaling 16 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of RGS16 mRNA CTD PMID:33854195 NCBI chr13:68,421,480...68,443,312
Ensembl chr13:65,887,530...65,892,857
JBrowse link
G Rhobtb3 Rho-related BTB domain containing 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of RHOBTB3 mRNA CTD PMID:33854195 NCBI chr 2:5,363,388...5,419,164
Ensembl chr 2:5,363,388...5,419,041
JBrowse link
G Rnase10 ribonuclease A family member 10 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of RNASE10 gene CTD PMID:33854195 NCBI chr15:26,700,219...26,702,681
Ensembl chr15:24,226,691...24,228,561
JBrowse link
G Rnd3 Rho family GTPase 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of RND3 gene; [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of RND3 mRNA CTD PMID:33854195 NCBI chr 3:55,981,142...55,998,494
Ensembl chr 3:35,571,143...35,589,327
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of RORC mRNA CTD PMID:33854195 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G Rxylt1 ribitol xylosyltransferase 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of RXYLT1 gene CTD PMID:33854195 NCBI chr 7:59,656,274...59,668,140
Ensembl chr 7:57,770,842...57,782,657
JBrowse link
G Sall4 spalt-like transcription factor 4 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of SALL4 gene CTD PMID:33854195 NCBI chr 3:177,891,705...177,909,743
Ensembl chr 3:157,474,642...157,490,822
JBrowse link
G Sardh sarcosine dehydrogenase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of SARDH mRNA CTD PMID:33854195 NCBI chr 3:30,908,621...30,973,409
Ensembl chr 3:10,510,553...10,573,874
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of SCNN1A mRNA CTD PMID:33854195 NCBI chr 4:159,809,187...159,832,409
Ensembl chr 4:158,122,962...158,146,181
JBrowse link
G Sdr42e1 short chain dehydrogenase/reductase family 42E, member 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of SDR42E1 mRNA CTD PMID:33854195 NCBI chr19:62,624,130...62,636,652
Ensembl chr19:45,715,399...45,727,901
JBrowse link
G Serpina1 serpin family A member 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of SERPINA1 mRNA CTD PMID:33854195 NCBI chr 6:128,631,101...128,653,125
Ensembl chr 6:122,866,312...122,888,339
JBrowse link
G Sesn2 sestrin 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of SESN2 mRNA CTD PMID:33854195 NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Setd6 SET domain containing 6, protein lysine methyltransferase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of SETD6 mRNA CTD PMID:33854195 NCBI chr19:9,349,011...9,356,515
Ensembl chr19:9,347,458...9,350,453
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of SFRP2 gene CTD PMID:33854195 NCBI chr 2:171,387,536...171,395,081
Ensembl chr 2:169,089,517...169,097,063
JBrowse link
G Sh3bp2 SH3-domain binding protein 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of SH3BP2 mRNA CTD PMID:33854195 NCBI chr14:80,400,685...80,437,887
Ensembl chr14:76,176,101...76,213,251
JBrowse link
G Sigirr single Ig and TIR domain containing multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of SIGIRR mRNA CTD PMID:33854195 NCBI chr 1:196,195,363...196,208,692
Ensembl chr 1:196,199,462...196,202,269
JBrowse link
G Sik2 salt-inducible kinase 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of SIK2 mRNA CTD PMID:33854195 NCBI chr 8:60,121,913...60,221,707
Ensembl chr 8:51,225,543...51,325,415
JBrowse link
G Sirt1 sirtuin 1 decreases expression ISO imidacloprid results in decreased expression of SIRT1 protein CTD PMID:27960282 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc12a6 solute carrier family 12, member 6 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of SLC12A6 mRNA CTD PMID:33854195 NCBI chr 3:99,071,577...99,170,266
Ensembl chr 3:99,071,391...99,170,258
JBrowse link
G Slc20a1 solute carrier family 20 member 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of SLC20A1 mRNA CTD PMID:33854195 NCBI chr 3:136,880,360...136,894,255
Ensembl chr 3:116,427,098...116,441,051
JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases activity ISO imidacloprid results in increased activity of SLC22A1 protein CTD PMID:31364238 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO imidacloprid results in decreased activity of SLC22A2 protein CTD PMID:31364238 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity ISO imidacloprid results in decreased activity of SLC22A8 protein CTD PMID:31364238 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc25a39 solute carrier family 25, member 39 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of SLC25A39 mRNA CTD PMID:33854195 NCBI chr10:87,362,494...87,367,358
Ensembl chr10:87,362,490...87,367,260
JBrowse link
G Slc26a6 solute carrier family 26 member 6 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of SLC26A6 mRNA CTD PMID:33854195 NCBI chr 8:118,438,110...118,448,271
Ensembl chr 8:109,559,642...109,569,778
JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases expression EXP imidacloprid results in increased expression of SLC2A2 mRNA CTD PMID:28850943 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression EXP imidacloprid results in increased expression of SLC2A3 mRNA CTD PMID:27782041 NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression ISO
EXP
imidacloprid results in decreased expression of SLC2A4 mRNA
imidacloprid results in decreased expression of SLC2A4 mRNA; imidacloprid results in decreased expression of SLC2A4 protein
CTD PMID:27960282 PMID:28850943 PMID:32685429 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc37a2 solute carrier family 37 member 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of SLC37A2 mRNA CTD PMID:33854195 NCBI chr 8:45,134,596...45,160,551
Ensembl chr 8:36,946,930...36,971,482
JBrowse link
G Slk STE20-like kinase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of SLK gene CTD PMID:33854195 NCBI chr 1:256,415,013...256,470,942
Ensembl chr 1:246,473,712...246,526,530
JBrowse link
G Smad7 SMAD family member 7 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of SMAD7 mRNA CTD PMID:33854195 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Smpx small muscle protein, X-linked multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of SMPX gene CTD PMID:33854195 NCBI chr  X:41,049,354...41,107,323
Ensembl chr  X:37,234,294...37,276,708
JBrowse link
G Snrnp200 small nuclear ribonucleoprotein U5 subunit 200 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of SNRNP200 mRNA CTD PMID:33854195 NCBI chr 3:134,882,173...134,911,512
Ensembl chr 3:114,428,854...114,458,182
JBrowse link
G Snx4 sorting nexin 4 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of SNX4 mRNA CTD PMID:33854195 NCBI chr11:80,965,965...81,023,234
Ensembl chr11:67,460,870...67,518,174
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of SOCS3 mRNA CTD PMID:33854195 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [imidacloprid co-treated with Dietary Fats] results in decreased expression of SOD1 mRNA CTD PMID:33487623 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of SOD3 mRNA CTD PMID:33854195 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Sohlh1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of SOHLH1 gene CTD PMID:33854195 NCBI chr 3:29,061,267...29,065,588
Ensembl chr 3:8,663,318...8,667,388
JBrowse link
G Spag1 sperm associated antigen 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of SPAG1 mRNA CTD PMID:33854195 NCBI chr 7:69,246,301...69,306,483
Ensembl chr 7:67,361,477...67,421,368
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of SRD5A2 gene CTD PMID:33854195 NCBI chr 6:27,178,089...27,217,588
Ensembl chr 6:21,426,215...21,462,112
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO imidacloprid results in increased expression of SREBF1 mRNA CTD PMID:27960282 PMID:33487623 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression
multiple interactions
ISO imidacloprid results in increased expression of SREBF2 mRNA
[imidacloprid co-treated with Dietary Fats] results in increased expression of SREBF2 mRNA
CTD PMID:33487623 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
G Srrm2 serine/arginine repetitive matrix 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of SRRM2 mRNA CTD PMID:33854195 NCBI chr10:13,320,059...13,353,337
Ensembl chr10:12,815,471...12,848,751
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of SRSF5 mRNA CTD PMID:33854195 NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:100,605,456...100,610,177
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
multiple interactions
ISO
EXP
imidacloprid results in decreased expression of STAR mRNA
Thymol inhibits the reaction [imidacloprid results in decreased expression of STAR mRNA]
CTD PMID:31780179 PMID:34171690 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stard9 StAR-related lipid transfer domain containing 9 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of STARD9 mRNA CTD PMID:33854195 NCBI chr 3:128,034,866...128,150,493
Ensembl chr 3:107,581,164...107,673,898
JBrowse link
G Susd2 sushi domain containing 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of SUSD2 mRNA CTD PMID:33854195 NCBI chr20:13,016,960...13,024,264
Ensembl chr20:13,017,477...13,024,903
JBrowse link
G Sympk symplekin scaffold protein multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of SYMPK mRNA CTD PMID:33854195 NCBI chr 1:78,672,372...78,700,684
Ensembl chr 1:78,672,378...78,700,684
JBrowse link
G Tacr3 tachykinin receptor 3 increases expression EXP imidacloprid results in increased expression of TACR3 mRNA CTD PMID:27782041 NCBI chr 2:225,940,497...226,037,756
Ensembl chr 2:223,266,536...223,363,791
JBrowse link
G Tada2b transcriptional adaptor 2B increases expression EXP imidacloprid results in increased expression of TADA2B mRNA CTD PMID:27782041 NCBI chr14:78,503,939...78,523,715
Ensembl chr14:74,279,217...74,290,755
JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of TAT mRNA CTD PMID:33854195 NCBI chr19:54,856,604...54,867,168
Ensembl chr19:37,947,112...37,958,031
JBrowse link
G Tdp2 tyrosyl-DNA phosphodiesterase 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of TDP2 mRNA CTD PMID:33854195 NCBI chr17:40,228,943...40,240,337
Ensembl chr17:40,228,947...40,240,313
JBrowse link
G Tead2 TEA domain transcription factor 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of TEAD2 mRNA CTD PMID:33854195 NCBI chr 1:104,838,795...104,855,635
Ensembl chr 1:95,703,005...95,719,186
JBrowse link
G Tecr trans-2,3-enoyl-CoA reductase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of TECR mRNA CTD PMID:33854195 NCBI chr19:41,431,422...41,472,880
Ensembl chr19:24,541,615...24,568,168
JBrowse link
G Tfap2a transcription factor AP-2 alpha multiple interactions ISO [imidacloprid co-treated with Dietary Fats] results in decreased expression of TFAP2A mRNA CTD PMID:33487623 NCBI chr17:24,230,064...24,253,219
Ensembl chr17:24,024,432...24,047,507
JBrowse link
G Tgds TDP-glucose 4,6-dehydratase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of TGDS mRNA CTD PMID:33854195 NCBI chr15:101,581,765...101,602,779
Ensembl chr15:95,174,608...95,195,554
JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects expression EXP imidacloprid affects the expression of TGFB1 mRNA CTD PMID:39002876 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbi transforming growth factor, beta induced multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of TGFBI mRNA CTD PMID:33854195 NCBI chr17:7,960,885...7,990,234
Ensembl chr17:7,955,603...7,985,240
JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases expression
EXP [conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; [conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid results in increased expression of TH mRNA]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with exoenzyme C3, Clostridium botulinum] inhibits the reaction [imidacloprid results in increased expression of TH mRNA]; conotoxin AuIB inhibits the reaction [imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]]; conotoxin AuIB inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; conotoxin AuIB inhibits the reaction [imidacloprid results in increased expression of TH mRNA]; exoenzyme C3, Clostridium botulinum inhibits the reaction [imidacloprid results in increased expression of TH mRNA]; imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]; imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]; imidacloprid promotes the reaction [Nicotine results in increased expression of TH protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [imidacloprid results in increased expression of TH mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid promotes the reaction [Acetylcholine results in increased expression of TH mRNA]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid results in increased expression of TH mRNA]; ZM 241385 inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; ZM 241385 inhibits the reaction [imidacloprid results in increased expression of TH mRNA]
imidacloprid results in increased expression of TH mRNA; imidacloprid results in increased expression of TH protein
CTD PMID:29246838 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thrb thyroid hormone receptor beta affects binding ISO imidacloprid binds to THRB protein CTD PMID:28973306 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 affects methylation
multiple interactions
ISO imidacloprid affects the methylation of TIMP3 promoter
LIF protein affects the reaction [imidacloprid affects the methylation of TIMP3 promoter]
CTD PMID:33865946 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:17,521,919...17,571,839
JBrowse link
G Tjap1 tight junction associated protein 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of TJAP1 mRNA CTD PMID:33854195 NCBI chr 9:14,701,418...14,725,623
Ensembl chr 9:14,701,468...14,725,751
JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP imidacloprid results in decreased expression of TJP1 mRNA CTD PMID:27792329 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tk1 thymidine kinase 1 increases mutagenesis ISO imidacloprid results in increased mutagenesis of TK1 gene CTD PMID:30103639 NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,031,521...103,046,920
JBrowse link
G Tkt transketolase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of TKT mRNA CTD PMID:33854195 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of TMBIM6 mRNA CTD PMID:33854195 NCBI chr 7:132,405,217...132,422,492
Ensembl chr 7:130,527,316...130,543,633
JBrowse link
G Tmem268 transmembrane protein 268 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of TMEM268 mRNA CTD PMID:33854195 NCBI chr 5:81,990,314...82,016,970
Ensembl chr 5:76,977,310...77,001,452
JBrowse link
G Tmt1b thiol methyltransferase 1B multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of TMT1B mRNA CTD PMID:33854195 NCBI chr 7:1,388,876...1,391,526
Ensembl chr 7:1,388,879...1,391,526
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
Dietary Fats promotes the reaction [imidacloprid results in increased expression of TNF mRNA]; imidacloprid promotes the reaction [Dietary Fats results in increased expression of TNF mRNA]
imidacloprid results in increased expression of TNF mRNA; imidacloprid results in increased expression of TNF protein
Plant Extracts inhibits the reaction [imidacloprid results in increased expression of TNF mRNA]
CTD PMID:27960282 PMID:34993831 PMID:35398170 PMID:39002876 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip2 TNF alpha induced protein 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of TNFAIP2 mRNA CTD PMID:33854195 NCBI chr 6:136,297,388...136,311,106
Ensembl chr 6:130,476,889...130,489,914
JBrowse link
G Tnni2 troponin I2, fast skeletal type decreases expression EXP imidacloprid results in decreased expression of TNNI2 mRNA CTD PMID:27782041 NCBI chr 1:206,882,358...207,027,034
Ensembl chr 1:197,594,813...197,597,560
JBrowse link
G Tor3a torsin family 3, member A multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of TOR3A mRNA CTD PMID:33854195 NCBI chr13:71,324,073...71,348,625
Ensembl chr13:68,769,605...68,798,475
JBrowse link
G Traf3ip2 Traf3 interacting protein 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of TRAF3IP2 mRNA CTD PMID:33854195 NCBI chr20:44,565,992...44,609,240
Ensembl chr20:43,011,450...43,054,667
JBrowse link
G Trafd1 TRAF type zinc finger domain containing 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of TRAFD1 mRNA CTD PMID:33854195 NCBI chr12:40,826,251...40,840,169
Ensembl chr12:35,165,606...35,179,525
JBrowse link
G Trim34 tripartite motif-containing 34 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of TRIM34 mRNA CTD PMID:33854195 NCBI chr 1:168,119,043...168,130,544
Ensembl chr 1:158,707,172...158,718,674
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of TSC22D3 mRNA CTD PMID:33854195 NCBI chr  X:109,006,410...109,066,389
Ensembl chr  X:104,217,925...104,276,861
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO [mancozeb co-treated with imidacloprid] results in increased expression of TSHB protein CTD PMID:24530807 NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Tspo translocator protein decreases expression ISO imidacloprid results in decreased expression of TSPO mRNA CTD PMID:31780179 NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:114,720,188...114,730,450
JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression EXP imidacloprid results in decreased expression of TUBB3 mRNA CTD PMID:39002876 NCBI chr19:68,365,687...68,374,741
Ensembl chr19:51,457,184...51,466,243
JBrowse link
G Txk TXK tyrosine kinase increases expression EXP imidacloprid results in increased expression of TXK mRNA CTD PMID:27782041 NCBI chr14:35,817,270...35,873,454
Ensembl chr14:35,463,944...35,519,448
JBrowse link
G Uba3 ubiquitin-like modifier activating enzyme 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of UBA3 mRNA CTD PMID:33854195 NCBI chr 4:129,789,526...129,810,707
Ensembl chr 4:129,789,204...129,810,606
JBrowse link
G Ubb ubiquitin B multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of UBB mRNA CTD PMID:33854195 NCBI chr10:47,746,923...47,748,628
Ensembl chr10:47,245,637...47,249,333
JBrowse link
G Ubc ubiquitin C multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of UBC mRNA CTD PMID:33854195 NCBI chr12:36,899,673...36,905,275
Ensembl chr12:31,239,152...31,243,925
JBrowse link
G Uckl1 uridine-cytidine kinase 1-like 1 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of UCKL1 mRNA CTD PMID:33854195 NCBI chr 3:168,674,849...168,687,513
Ensembl chr 3:168,674,849...168,698,091
JBrowse link
G Unc45a unc-45 myosin chaperone A multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of UNC45A mRNA CTD PMID:33854195 NCBI chr 1:143,691,183...143,705,944
Ensembl chr 1:134,281,933...134,301,586
JBrowse link
G Unc45b unc-45 myosin chaperone B decreases expression EXP imidacloprid results in decreased expression of UNC45B mRNA CTD PMID:27782041 NCBI chr10:68,343,011...68,370,683
Ensembl chr10:67,845,462...67,873,389
JBrowse link
G Usp2 ubiquitin specific peptidase 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of USP2 mRNA CTD PMID:33854195 NCBI chr 8:53,308,264...53,336,800
Ensembl chr 8:44,411,607...44,438,331
JBrowse link
G Usp40 ubiquitin specific peptidase 40 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of USP40 mRNA CTD PMID:33854195 NCBI chr 9:88,607,920...88,678,940
Ensembl chr 9:88,607,930...88,678,914
JBrowse link
G Vcl vinculin decreases expression EXP imidacloprid results in decreased expression of VCL mRNA CTD PMID:27792329 NCBI chr15:3,315,069...3,404,891
Ensembl chr15:3,265,815...3,355,606
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of VEGFA mRNA CTD PMID:33854195 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vldlr very low density lipoprotein receptor increases expression EXP imidacloprid results in increased expression of VLDLR mRNA CTD PMID:39002876 NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:224,814,377...224,845,920
JBrowse link
G Vnn3 vanin 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of VNN3 mRNA CTD PMID:33854195 NCBI chr 1:21,571,364...21,583,626
Ensembl chr 1:21,571,364...21,583,626
JBrowse link
G Vtn vitronectin multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of VTN mRNA CTD PMID:33854195 NCBI chr10:63,892,782...63,895,862
Ensembl chr10:63,394,719...63,397,810
JBrowse link
G Wdr11 WD repeat domain 11 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of WDR11 gene CTD PMID:33854195 NCBI chr 1:193,595,606...193,641,149
Ensembl chr 1:184,165,571...184,210,846
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of WEE1 mRNA CTD PMID:33854195 NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:164,174,779...164,197,688
JBrowse link
G Wfdc9 WAP four-disulfide core domain 9 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of WFDC9 gene CTD PMID:33854195 NCBI chr 3:173,799,888...173,808,383
Ensembl chr 3:153,380,649...153,391,261
JBrowse link
G Yod1 YOD1 deubiquitinase multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased methylation of YOD1 gene CTD PMID:33854195 NCBI chr13:42,175,047...42,181,661
Ensembl chr13:42,174,820...42,177,205
JBrowse link
G Zfc3h1 zinc finger, C3H1-type containing multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of ZFC3H1 mRNA CTD PMID:33854195 NCBI chr 7:51,008,251...51,064,666
Ensembl chr 7:51,007,984...51,064,661
JBrowse link
G Zfp280d zinc finger protein 280D multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of ZFP280D mRNA CTD PMID:33854195 NCBI chr 8:81,872,108...81,961,194
Ensembl chr 8:72,992,650...73,080,480
JBrowse link
G Zfp36l2 zinc finger protein 36, C3H type-like 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of ZFP36L2 mRNA CTD PMID:33854195 NCBI chr 6:16,242,622...16,246,662
Ensembl chr 6:10,490,032...10,494,064
JBrowse link
G Zfp422 zinc finger protein 422 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of ZFP422 mRNA CTD PMID:33854195 NCBI chr 4:151,558,254...151,565,730
Ensembl chr 4:149,885,600...149,893,257
JBrowse link
G Zfp598 zinc finger protein 598 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of ZFP598 mRNA CTD PMID:33854195 NCBI chr10:14,198,763...14,210,773
Ensembl chr10:13,694,286...13,706,233
JBrowse link
G Zmym3 zinc finger MYM-type containing 3 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of ZMYM3 mRNA CTD PMID:33854195 NCBI chr  X:70,568,573...70,584,221
Ensembl chr  X:66,528,585...66,544,782
JBrowse link
G Zmym6 zinc finger MYM-type containing 6 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of ZMYM6 mRNA CTD PMID:33854195 NCBI chr 5:139,396,374...139,444,357
Ensembl chr 5:139,396,727...139,444,279
JBrowse link
G Zranb2 zinc finger RANBP2-type containing 2 multiple interactions EXP [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of ZRANB2 mRNA CTD PMID:33854195 NCBI chr 2:246,573,110...246,586,942
Ensembl chr 2:246,573,166...246,586,942
JBrowse link
nicotine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aacs acetoacetyl-CoA synthetase decreases expression
increases methylation
EXP Nicotine results in decreased expression of AACS mRNA
Nicotine results in increased methylation of AACS promoter
CTD PMID:26776438 NCBI chr12:36,774,471...36,817,835
Ensembl chr12:31,113,098...31,160,954
JBrowse link
G Aatk apoptosis-associated tyrosine kinase increases expression ISO Nicotine results in increased expression of AATK mRNA CTD PMID:18247414 NCBI chr10:105,789,171...105,825,634
Ensembl chr10:105,291,585...105,327,112
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of ABCA1 mRNA; Nicotine results in decreased expression of ABCA1 protein
GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]
CTD PMID:30036686 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression
increases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of ABCG1 mRNA; Nicotine results in decreased expression of ABCG1 protein
Nicotine results in increased expression of ABCG1 protein
GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]
CTD PMID:30036686 PMID:31629012 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Nicotine results in increased expression of ABCG2 mRNA CTD PMID:17997037 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Abtb3 ankyrin repeat and BTB domain containing 3 increases expression ISO Nicotine results in increased expression of ABTB3 mRNA CTD PMID:21955143 PMID:23825647 NCBI chr 7:19,922,883...20,199,740
Ensembl chr 7:18,036,083...18,310,834
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ACAA2 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ACAA2 mRNA] CTD PMID:20230807 NCBI chr18:70,620,310...70,648,417
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression EXP Nicotine results in increased expression of ACACA mRNA CTD PMID:24368177 PMID:29155039 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acan aggrecan decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of ACAN mRNA; Nicotine results in decreased expression of ACAN protein
NLRP3 protein affects the reaction [Nicotine results in decreased expression of ACAN mRNA]
CTD PMID:29660438 PMID:31299270 PMID:34245815 PMID:39098741 NCBI chr 1:142,390,951...142,453,779
Ensembl chr 1:132,981,582...133,043,627
JBrowse link
G Ace angiotensin I converting enzyme increases expression ISO Nicotine results in increased expression of ACE mRNA CTD PMID:11166759 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ache acetylcholinesterase decreases activity
increases activity
multiple interactions
EXP Nicotine results in decreased activity of ACHE protein
Nicotine results in increased activity of ACHE protein
Nicotine inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein]
CTD PMID:20097188 PMID:21633116 PMID:23033686 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acot13 acyl-CoA thioesterase 13 decreases expression ISO Nicotine results in decreased expression of ACOT13 mRNA CTD PMID:17997037 NCBI chr17:40,668,404...40,680,876
Ensembl chr17:40,240,378...40,252,851
JBrowse link
G Acp1 acid phosphatase 1 decreases expression ISO Nicotine results in decreased expression of ACP1 mRNA CTD PMID:17997037 NCBI chr 6:53,233,937...53,249,576
Ensembl chr 6:47,506,380...47,522,021
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases splicing ISO Nicotine results in increased splicing of ACSL1 mRNA alternative form CTD PMID:23825647 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 multiple interactions
increases expression
ISO
EXP
Mecamylamine inhibits the reaction [Nicotine results in increased expression of ACSL6 protein]
Nicotine results in increased expression of ACSL6 mRNA
CTD PMID:22205969 NCBI chr10:38,940,668...38,999,515
Ensembl chr10:38,440,080...38,498,757
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of ACTA1 mRNA
Nicotine results in decreased expression of ACTA1 mRNA
CTD PMID:17997037 PMID:27782041 NCBI chr19:68,781,168...68,784,194
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO
EXP
Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Nicotine promotes the reaction [Quartz results in increased expression of ACTA2 protein]
Nicotine results in increased expression of ACTA2 protein
Bungarotoxins inhibits the reaction [Nicotine results in increased expression of ACTA2 protein]; Nicotine promotes the reaction [Arginine results in increased expression of ACTA2 protein]
Nicotine results in increased expression of ACTA2 mRNA; Nicotine results in increased expression of ACTA2 protein
CTD PMID:33640489 PMID:34153408 PMID:36720419 PMID:36868510 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actb actin, beta increases expression ISO Nicotine results in increased expression of ACTB mRNA CTD PMID:17997037 NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Actr1a actin related protein 1A multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ACTR1A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ACTR1A mRNA] CTD PMID:20230807 NCBI chr 1:255,179,241...255,199,009
Ensembl chr 1:245,237,826...245,256,495
JBrowse link
G Actrt2 actin-related protein T2 decreases expression EXP Nicotine results in decreased expression of ACTRT2 mRNA CTD PMID:27782041 NCBI chr 5:170,518,470...170,519,870
Ensembl chr 5:165,236,086...165,237,629
JBrowse link
G Ada adenosine deaminase increases activity
multiple interactions
EXP Nicotine results in increased activity of ADA protein
Sodium Acetate inhibits the reaction [Nicotine results in increased activity of ADA protein]
CTD PMID:31857090 NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Adam19 ADAM metallopeptidase domain 19 increases expression ISO Nicotine results in increased expression of ADAM19 mRNA CTD PMID:23825647 NCBI chr10:30,992,713...31,084,455
Ensembl chr10:30,491,405...30,583,105
JBrowse link
G Adcy7 adenylate cyclase 7 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ADCY7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA] CTD PMID:20230807 NCBI chr19:34,913,154...34,972,366
Ensembl chr19:18,740,875...18,776,311
JBrowse link
G Adgra1 adhesion G protein-coupled receptor A1 decreases expression ISO Nicotine results in decreased expression of ADGRA1 mRNA CTD PMID:21955143 NCBI chr 1:204,059,218...204,102,869
Ensembl chr 1:194,629,726...194,672,550
JBrowse link
G Adgrg1 adhesion G protein-coupled receptor G1 increases expression ISO Nicotine results in increased expression of ADGRG1 mRNA CTD PMID:23825647 NCBI chr19:10,009,983...10,047,138
Ensembl chr19:10,003,975...10,041,108
JBrowse link
G Adgrl1 adhesion G protein-coupled receptor L1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADGRL1 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ADGRL1 mRNA] CTD PMID:20230807 NCBI chr19:41,107,162...41,148,752
Ensembl chr19:24,204,360...24,244,139
JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP Nicotine results in increased expression of ADIPOR2 mRNA CTD PMID:22265867 NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:152,524,623...152,559,355
JBrowse link
G Adk adenosine kinase increases expression ISO Nicotine results in increased expression of ADK mRNA CTD PMID:17997037 NCBI chr15:2,912,543...3,295,745
Ensembl chr15:2,863,244...3,246,510
JBrowse link
G Adm2 adrenomedullin 2 multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in decreased expression of ADM2 protein CTD PMID:19910445 NCBI chr 7:122,272,808...122,274,594
Ensembl chr 7:120,393,179...120,396,331
JBrowse link
G Adnp activity-dependent neuroprotector homeobox multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADNP mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADNP mRNA] CTD PMID:20230807 NCBI chr 3:177,310,258...177,340,379
Ensembl chr 3:156,891,381...156,917,312
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Nicotine results in decreased expression of ADORA2A mRNA CTD PMID:21955143 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions
increases expression
ISO [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine
Nicotine results in increased expression of ADRB1 mRNA
CTD PMID:17003101 PMID:17369603 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases expression
ISO [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] which results in decreased susceptibility to Nicotine
Nicotine results in increased expression of ADRB2 mRNA
CTD PMID:17003101 PMID:17369603 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Adtrp androgen-dependent TFPI-regulating protein increases expression ISO Nicotine results in increased expression of ADTRP mRNA CTD PMID:23825647 NCBI chr17:23,113,578...23,199,616
Ensembl chr17:22,930,740...22,993,826
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression EXP Nicotine results in increased expression of AGTR1A protein CTD PMID:22691361 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr1b angiotensin II receptor, type 1b increases expression EXP Nicotine results in increased expression of AGTR1B mRNA CTD PMID:22728133 NCBI chr 2:104,774,005...104,849,262
Ensembl chr 2:102,844,969...102,920,232
JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression
affects expression
EXP Nicotine results in decreased expression of AGTR2 mRNA; Nicotine results in decreased expression of AGTR2 protein
Nicotine affects the expression of AGTR2 protein
CTD PMID:19429393 PMID:22691361 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Nicotine results in increased expression of AHR mRNA CTD PMID:34171359 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor decreases expression EXP Nicotine results in decreased expression of AHRR protein CTD PMID:35577041 NCBI chr 1:30,822,219...30,917,251
Ensembl chr 1:28,993,634...29,088,673
JBrowse link
G Ak3 adenylate kinase 3 increases expression ISO Nicotine results in increased expression of AK3 mRNA CTD PMID:17456735 NCBI chr 1:236,151,012...236,178,689
Ensembl chr 1:226,739,318...226,764,625
JBrowse link
G Ak5 adenylate kinase 5 increases expression ISO Nicotine results in increased expression of AK5 mRNA CTD PMID:21955143 NCBI chr 2:244,057,240...244,241,372
Ensembl chr 2:241,397,297...241,581,458
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of AKR1A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AKR1A1 mRNA] CTD PMID:20230807 NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
increases expression
increases phosphorylation
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein; [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein; CDK1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CDK2 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CSNK2A1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of AKT1 protein modified form]; CYP1A1 protein affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; Nicotine affects the reaction [Camptothecin affects the phosphorylation of AKT1 protein]; Nicotine affects the reaction [Fluorouracil affects the phosphorylation of AKT1 protein]; Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein
Nicotine results in decreased phosphorylation of AKT1 protein
Nicotine results in increased expression of AKT1 mRNA
CTD PMID:12511591 PMID:15983034 PMID:20727180 PMID:24095863 PMID:30836163 More... NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 affects expression
increases expression
EXP
ISO
Nicotine affects the expression of AKT2 mRNA
Nicotine results in increased expression of AKT2 mRNA
CTD PMID:31945395 PMID:31972234 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Alad aminolevulinate dehydratase decreases activity ISO Nicotine results in decreased activity of ALAD protein CTD PMID:8687997 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Alb albumin increases expression
decreases expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of ALB protein
Nicotine results in decreased expression of ALB protein
dexpanthenol inhibits the reaction [Nicotine results in decreased expression of ALB protein]
CTD PMID:25662863 PMID:36720419 PMID:38229321 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases activity
multiple interactions
ISO Nicotine results in increased activity of ALDH1A1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA]
CTD PMID:20230807 PMID:23219715 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type increases expression ISO Nicotine results in increased expression of ALOX12 mRNA CTD PMID:16254210 NCBI chr10:55,456,923...55,469,239
Ensembl chr10:54,958,271...54,970,542
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
increases expression
ISO [RTKI cpd co-treated with AG 1879] inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; AG 1879 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; RTKI cpd inhibits the reaction [Nicotine results in increased expression of ALOX5 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of ALOX5 mRNA]
Nicotine results in increased expression of ALOX5 mRNA; Nicotine results in increased expression of ALOX5 protein
CTD PMID:14569062 PMID:20061081 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 increases expression ISO Nicotine results in increased expression of AMD1 mRNA CTD PMID:16949557 NCBI chr20:45,250,289...45,324,939
Ensembl chr20:43,697,237...43,711,476
JBrowse link
G Amhr2 anti-Mullerian hormone receptor type 2 decreases expression ISO Nicotine results in decreased expression of AMHR2 mRNA CTD PMID:18247414 NCBI chr 7:135,454,517...135,470,183
Ensembl chr 7:133,579,393...133,588,258
JBrowse link
G Angpt4 angiopoietin 4 increases expression ISO Nicotine results in increased expression of ANGPT4 mRNA CTD PMID:23825647 NCBI chr 3:160,880,539...160,913,923
Ensembl chr 3:140,420,389...140,453,583
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression EXP Nicotine results in decreased expression of ANGPTL4 mRNA CTD PMID:32512034 NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Ano3 anoctamin 3 decreases expression ISO Nicotine results in decreased expression of ANO3 mRNA CTD PMID:21955143 NCBI chr 3:117,690,242...118,004,695
Ensembl chr 3:97,238,354...97,550,154
JBrowse link
G Anxa1 annexin A1 decreases expression EXP Nicotine results in decreased expression of ANXA1 mRNA CTD PMID:26776438 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Apeh acylaminoacyl-peptide hydrolase decreases expression ISO Nicotine results in decreased expression of APEH mRNA CTD PMID:16949557 NCBI chr 8:117,652,390...117,661,502
Ensembl chr 8:108,773,794...108,782,933
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA] CTD PMID:20230807 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Api5 apoptosis inhibitor 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of API5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of API5 mRNA] CTD PMID:20230807 NCBI chr 3:100,833,417...100,858,580
Ensembl chr 3:80,378,096...80,403,264
JBrowse link
G Apoe apolipoprotein E increases expression ISO Nicotine results in increased expression of APOE mRNA CTD PMID:17997037 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases metabolic processing
decreases expression
ISO
EXP
[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form; Bungarotoxins inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]]; Mecamylamine inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]]; Nicotine inhibits the reaction [Copper promotes the reaction [APP protein binds to APP protein]]; Nicotine inhibits the reaction [Copper results in increased expression of APP mRNA]; Nicotine inhibits the reaction [Copper results in increased expression of APP protein]; Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form]; Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein]
APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]; spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one inhibits the reaction [APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]]
Nicotine results in decreased expression of APP protein alternative form
Nicotine results in decreased expression of APP mRNA; Nicotine results in decreased expression of APP protein
CTD PMID:16474004 PMID:16627626 PMID:17135361 PMID:29618714 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp4 aquaporin 4 increases expression ISO Nicotine results in increased expression of AQP4 mRNA CTD PMID:21955143 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression ISO Nicotine results in increased expression of ARC mRNA CTD PMID:23825647 NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Arf1 ARF GTPase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ARF1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA] CTD PMID:20230807 NCBI chr10:44,497,543...44,513,994
Ensembl chr10:43,997,986...44,014,434
JBrowse link
G Arf3 ARF GTPase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ARF3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF3 mRNA] CTD PMID:20230807 NCBI chr 7:131,765,039...131,792,075
Ensembl chr 7:129,886,082...129,912,002
JBrowse link
G Arglu1 arginine and glutamate rich 1 increases expression ISO Nicotine results in increased expression of ARGLU1 mRNA CTD PMID:16949557 NCBI chr16:87,455,097...87,479,148
Ensembl chr16:80,753,315...80,777,349
JBrowse link
G Arhgef26 Rho guanine nucleotide exchange factor 26 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARHGEF26 mRNA CTD PMID:28065790 NCBI chr 2:148,889,405...149,000,538
Ensembl chr 2:146,739,631...146,850,819
JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 decreases expression ISO Nicotine results in decreased expression of ARHGEF7 mRNA CTD PMID:12588870 NCBI chr16:84,373,123...84,484,759
Ensembl chr16:77,671,023...77,782,697
JBrowse link
G Arid1a AT-rich interaction domain 1A decreases expression ISO Nicotine results in decreased expression of ARID1A mRNA CTD PMID:17997037 NCBI chr 5:151,192,014...151,269,291
Ensembl chr 5:145,908,181...145,985,564
JBrowse link
G Arl15 ARF like GTPase 15 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of ARL15 mRNA CTD PMID:28065790 NCBI chr 2:47,171,377...47,555,666
Ensembl chr 2:45,438,242...45,822,559
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator decreases expression EXP Nicotine results in decreased expression of ARNT protein CTD PMID:35577041 NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 decreases expression ISO Nicotine results in decreased expression of ARPP21 mRNA CTD PMID:21955143 NCBI chr 8:120,912,964...121,077,586
Ensembl chr 8:112,034,642...112,194,297
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine results in increased phosphorylation of and results in increased activity of SRC protein] CTD PMID:16862215 NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Arvcf ARVCF, delta catenin family member decreases response to substance ISO ARVCF gene mutant form results in decreased susceptibility to Nicotine CTD PMID:38025780 NCBI chr11:96,092,451...96,150,144
Ensembl chr11:82,587,881...82,645,805
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 decreases expression EXP Nicotine results in decreased expression of ASCL1 mRNA CTD PMID:28555334 NCBI chr 7:23,790,642...23,793,509
Ensembl chr 7:21,903,126...21,905,993
JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 decreases expression EXP Nicotine results in decreased expression of ASCL2 mRNA CTD PMID:24368670 NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:198,148,999...198,151,406
JBrowse link
G Aspm assembly factor for spindle microtubules multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ASPM mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ASPM mRNA] CTD PMID:20230807 NCBI chr13:53,625,584...53,674,489
Ensembl chr13:51,074,849...51,123,755
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Nicotine results in increased expression of ATF3 mRNA CTD PMID:17456735 PMID:24927667 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Nicotine inhibits the reaction [Tunicamycin results in increased expression of ATF6 protein] CTD PMID:18477628 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form] CTD PMID:23907605 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atoh1 atonal bHLH transcription factor 1 multiple interactions
increases expression
ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of ATOH1 mRNA] CTD PMID:23056257 NCBI chr 4:95,241,933...95,244,028
Ensembl chr 4:93,912,068...93,914,154
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression EXP Nicotine results in decreased expression of ATP5F1A protein CTD PMID:28681937 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon increases splicing ISO Nicotine results in increased splicing of ATP5F1E mRNA alternative form CTD PMID:23825647 NCBI chr 3:183,677,270...183,680,172
Ensembl chr 3:163,260,476...163,261,450
JBrowse link
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ATP6V0A4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V0A4 mRNA] CTD PMID:20230807 NCBI chr 4:67,727,145...67,809,092
Ensembl chr 4:66,760,159...66,842,110
JBrowse link
G Atp9a ATPase phospholipid transporting 9A (putative) multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ATP9A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP9A mRNA] CTD PMID:20230807 NCBI chr 3:177,779,203...177,886,431
Ensembl chr 3:157,360,359...157,467,818
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form] CTD PMID:23907605 NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Atrn attractin multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATRN mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ATRN mRNA] CTD PMID:20230807 NCBI chr 3:138,563,271...138,697,360
Ensembl chr 3:118,110,229...118,244,322
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression
decreases expression
ISO Nicotine results in increased expression of ATRX mRNA
Nicotine results in decreased expression of ATRX mRNA
CTD PMID:16949557 PMID:21955143 NCBI chr  X:74,916,548...75,062,880
Ensembl chr  X:70,850,981...70,997,330
JBrowse link
G Avp arginine vasopressin decreases expression
increases secretion
ISO
EXP
Nicotine results in decreased expression of AVP mRNA
Nicotine results in increased secretion of AVP protein alternative form
CTD PMID:3681699 PMID:17456735 PMID:28555334 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G B4galt2 beta-1,4-galactosyltransferase 2 decreases expression ISO Nicotine results in decreased expression of B4GALT2 mRNA CTD PMID:17997037 NCBI chr 5:136,697,981...136,707,783
Ensembl chr 5:131,412,541...131,421,013
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
decreases phosphorylation
ISO
EXP
Nicotine results in decreased expression of BAD mRNA
Nicotine results in decreased phosphorylation of BAD protein
CTD PMID:18247414 PMID:20447445 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bap1 BRCA1 associated deubiquitinase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BAP1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAP1 mRNA] CTD PMID:20230807 NCBI chr16:6,453,126...6,461,952
Ensembl chr16:6,446,709...6,455,535
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases phosphorylation
decreases expression
increases expression
multiple interactions
affects localization
ISO
EXP
Nicotine results in increased phosphorylation of BAX protein
Nicotine results in decreased expression of BAX protein
Nicotine results in increased expression of BAX protein
dexpanthenol inhibits the reaction [Nicotine results in increased expression of BAX protein]; Folic Acid inhibits the reaction [Nicotine results in increased expression of BAX protein]
Nicotine results in increased expression of BAX mRNA; Nicotine results in increased expression of BAX protein
Nicotine affects the localization of BAX protein
Nicotine results in decreased expression of BAX mRNA; Nicotine results in decreased expression of BAX protein
3-methyladenine inhibits the reaction [Nicotine results in increased expression of BAX protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of BAX protein; MK-886 inhibits the reaction [Nicotine results in decreased expression of BAX protein]; Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] affects the localization of BAX protein]; PRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein]
CTD PMID:15831280 PMID:17135361 PMID:17525161 PMID:18203686 PMID:18676776 More... NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcas1 brain enriched myelin associated protein 1 increases expression ISO Nicotine results in increased expression of BCAS1 mRNA CTD PMID:21955143 NCBI chr 3:179,554,754...179,637,800
Ensembl chr 3:159,136,083...159,219,106
JBrowse link
G Bcl11b BCL11 transcription factor B increases expression ISO Nicotine results in increased expression of BCL11B mRNA CTD PMID:21955143 NCBI chr 6:132,598,968...132,692,123
Ensembl chr 6:126,834,531...126,928,224
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression
increases phosphorylation
ISO
EXP
3-methyladenine inhibits the reaction [Nicotine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; edelfosine inhibits the reaction [Nicotine results in increased phosphorylation of BCL2 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of BCL2 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of BCL2 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein]
royal jelly inhibits the reaction [Nicotine results in decreased expression of BCL2 mRNA]
Folic Acid inhibits the reaction [Nicotine results in decreased expression of BCL2 protein]
Nicotine results in decreased expression of BCL2 mRNA; Nicotine results in decreased expression of BCL2 protein
Nicotine results in increased expression of BCL2 mRNA; Nicotine results in increased expression of BCL2 protein; Nicotine results in increased expression of BCL2 protein modified form
CTD PMID:12421819 PMID:15831280 PMID:18448488 PMID:18676776 PMID:20061081 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Nicotine results in decreased expression of BCL2A1 mRNA CTD PMID:18247414 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of BCL2L1 mRNA
Nicotine results in decreased expression of BCL2L1 protein
resveratrol inhibits the reaction [Nicotine results in decreased expression of BCL2L1 mRNA]
CTD PMID:22687363 PMID:38229321 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479
JBrowse link
G Bcl2l10 Bcl2-like 10 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2L10 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2L10 mRNA] CTD PMID:20230807 NCBI chr 8:84,987,833...84,993,878
Ensembl chr 8:76,107,326...76,113,367
JBrowse link
G Bdnf brain-derived neurotrophic factor affects response to substance
multiple interactions
increases expression
affects expression
increases secretion
ISO
EXP
BDNF gene polymorphism affects the susceptibility to Nicotine
[Nicotine co-treated with Quartz] results in increased expression of BDNF protein
Nicotine results in increased expression of BDNF mRNA
Nicotine affects the expression of BDNF mRNA
Nicotine results in increased secretion of BDNF protein
methyllycaconitine inhibits the reaction [Nicotine results in increased secretion of BDNF protein]
CTD PMID:9503263 PMID:9832142 PMID:16790237 PMID:17186223 PMID:20426880 More... NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of BECN1 mRNA
dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]]; Nicotine promotes the reaction [Dextran Sulfate results in increased expression of BECN1 protein]
CTD PMID:30605750 PMID:31926917 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
decreases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of BGLAP
Nicotine results in decreased expression of BGLAP mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP]
CTD PMID:19436947 PMID:29981921 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of BIRC2 protein
Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC2 protein]
CTD PMID:20727180 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression
ISO Curcumin inhibits the reaction [Nicotine results in increased expression of BIRC5 protein]; Hexamethonium affects the reaction [Nicotine results in increased expression of BIRC5 protein]; Nicotine inhibits the reaction [RB1 protein binds to BIRC5 promoter]; Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter]
Nicotine results in increased expression of BIRC5 mRNA; Nicotine results in increased expression of BIRC5 protein
CTD PMID:16601104 PMID:19896492 PMID:20727180 PMID:21267677 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger increases expression
multiple interactions
ISO Nicotine results in increased expression of BMI1 mRNA; Nicotine results in increased expression of BMI1 protein
SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA]
CTD PMID:23219715 NCBI chr17:86,240,683...86,250,044
Ensembl chr17:81,332,214...81,388,690
JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression EXP Nicotine results in decreased expression of BMP4 mRNA CTD PMID:20339300 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions ISO [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PRDM16 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA CTD PMID:33091441 NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA] CTD PMID:20230807 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Nicotine results in decreased expression of BOK mRNA CTD PMID:21955143 NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression ISO Nicotine results in decreased expression of BRAF mRNA; Nicotine results in decreased expression of BRAF protein CTD PMID:17135361 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
multiple interactions
ISO Nicotine results in decreased expression of BRCA1 mRNA
Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form]
CTD PMID:18247414 PMID:23907605 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brd2 bromodomain containing 2 increases expression ISO Nicotine results in increased expression of BRD2 mRNA CTD PMID:33640489 NCBI chr20:4,728,282...4,737,286
Ensembl chr20:4,728,151...4,735,388
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of BST2 mRNA CTD PMID:37951547 NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,217,407...18,220,979
JBrowse link
G Btf3 basic transcription factor 3 decreases expression ISO Nicotine results in decreased expression of BTF3 mRNA CTD PMID:18247414 NCBI chr 2:31,394,010...31,401,138
Ensembl chr 2:29,659,231...29,666,879
Ensembl chr13:29,659,231...29,666,879
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Nicotine results in increased expression of BTG2 mRNA CTD PMID:17456735 NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Btk Bruton tyrosine kinase decreases expression ISO Nicotine results in decreased expression of BTK mRNA CTD PMID:18247414 NCBI chr  X:102,016,070...102,055,448
Ensembl chr  X:97,722,802...97,761,853
JBrowse link
G C1r complement C1r multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of C1R mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1R mRNA] CTD PMID:20230807 NCBI chr 4:159,099,013...159,109,770
Ensembl chr 4:157,412,692...157,423,484
JBrowse link
G C1s complement C1s multiple interactions ISO Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1S mRNA] CTD PMID:20230807 NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:157,430,117...157,442,303
JBrowse link
G C3ar1 complement C3a receptor 1 increases expression ISO Nicotine results in increased expression of C3AR1 mRNA CTD PMID:23825647 NCBI chr 4:157,747,419...157,756,609
Ensembl chr 4:156,075,389...156,084,701
JBrowse link
G C5ar1 complement C5a receptor 1 decreases expression ISO Nicotine results in decreased expression of C5AR1 mRNA CTD PMID:18247414 NCBI chr 1:86,077,309...86,088,001 JBrowse link
G C7 complement C7 multiple interactions
increases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of C7 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA] CTD PMID:16949557 NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:54,088,116...54,158,535
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C increases expression ISO Nicotine results in increased expression of CACNA1C protein CTD PMID:11756415 NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D increases expression ISO Nicotine results in increased expression of CACNA1D protein CTD PMID:11756415 NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,228,306...5,668,215
JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F increases expression ISO Nicotine results in increased expression of CACNA1F mRNA CTD PMID:11756415 NCBI chr  X:17,539,992...17,568,308
Ensembl chr  X:14,868,024...14,896,413
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H increases expression EXP Nicotine results in increased expression of CACNA1H mRNA CTD PMID:27782041 NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression ISO Nicotine results in increased expression of CACNA2D1 protein CTD PMID:11756415 NCBI chr 4:19,902,324...20,330,287
Ensembl chr 4:18,951,002...19,374,969
JBrowse link
G Cacng1 calcium voltage-gated channel auxiliary subunit gamma 1 decreases expression EXP Nicotine results in decreased expression of CACNG1 mRNA CTD PMID:27782041 NCBI chr10:93,152,558...93,165,246
Ensembl chr10:92,652,614...92,665,783
JBrowse link
G Cadm3 cell adhesion molecule 3 increases expression EXP Nicotine results in increased expression of CADM3 mRNA CTD PMID:27782041 NCBI chr13:88,317,124...88,349,718
Ensembl chr13:85,786,483...85,817,749
JBrowse link
G Calb1 calbindin 1 increases expression
multiple interactions
EXP Nicotine results in increased expression of CALB1 protein
Mecamylamine inhibits the reaction [Nicotine results in increased expression of CALB1 protein]
CTD PMID:11226671 NCBI chr 5:34,172,612...34,199,555
Ensembl chr 5:29,375,642...29,402,431
JBrowse link
G Calcrl calcitonin receptor like receptor multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in increased expression of CALCRL protein CTD PMID:19910445 NCBI chr 3:89,835,071...89,932,616
Ensembl chr 3:69,430,120...69,525,910
JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CALM1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CALM1 mRNA] CTD PMID:20230807 NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:119,487,621...119,498,227
JBrowse link
G Calr calreticulin increases expression ISO Nicotine results in increased expression of CALR mRNA CTD PMID:16949557 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha increases expression ISO Nicotine results in increased expression of CAMK2A mRNA CTD PMID:21955143 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression ISO Nicotine results in decreased expression of CAMK4 mRNA CTD PMID:17997037 NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,585,269...24,802,487
JBrowse link
G Camp cathelicidin antimicrobial peptide increases expression ISO Nicotine results in increased expression of CAMP mRNA CTD PMID:23825647 NCBI chr 8:118,720,184...118,721,998
Ensembl chr 8:109,841,729...109,843,543
JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 decreases expression ISO Nicotine results in decreased expression of CAP1 mRNA CTD PMID:21955143 NCBI chr 5:140,427,265...140,507,678
Ensembl chr 5:135,142,112...135,168,769
JBrowse link
G Capn10 calpain 10 increases expression ISO Nicotine results in increased expression of CAPN10 mRNA CTD PMID:17997037 NCBI chr 9:100,943,665...100,957,910
Ensembl chr 9:93,498,478...93,510,494
JBrowse link
G Capza2 capping actin protein of muscle Z-line subunit alpha 2 increases expression ISO Nicotine results in increased expression of CAPZA2 mRNA CTD PMID:16949557 NCBI chr 4:46,944,040...46,979,930
Ensembl chr 4:45,977,807...46,013,864
JBrowse link
G Car3 carbonic anhydrase 3 decreases expression EXP Nicotine results in decreased expression of CAR3 mRNA CTD PMID:27782041 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Cartpt CART prepropeptide decreases expression EXP
ISO
Nicotine results in decreased expression of CARTPT protein
Nicotine results in decreased expression of CARTPT mRNA
CTD PMID:18247414 PMID:23623838 NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:31,255,098...31,290,713
JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression
ISO
EXP
CHRNA5 protein affects the reaction [Nicotine results in increased expression of and results in increased cleavage of CASP1 protein]; Nicotine affects the reaction [Staurosporine affects the localization of CASP1 protein]; Nicotine inhibits the reaction [Staurosporine results in increased activity of CASP1 protein]; Nicotine results in increased expression of and results in increased cleavage of CASP1 protein
Nicotine results in increased expression of CASP1 mRNA
Nicotine results in increased expression of CASP1 protein
CTD PMID:16927020 PMID:35131329 PMID:39098741 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 multiple interactions ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP12 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP12 mRNA]
Nicotine inhibits the reaction [Tunicamycin results in increased activity of CASP12 protein]
CTD PMID:18477628 PMID:20230807 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp14 caspase 14 increases expression ISO Nicotine results in increased expression of CASP14 mRNA CTD PMID:23825647 NCBI chr 7:11,577,315...11,583,987
Ensembl chr 7:10,926,725...10,933,405
JBrowse link
G Casp2 caspase 2 affects expression EXP Nicotine affects the expression of CASP2 mRNA CTD PMID:20426880 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
affects expression
decreases expression
decreases activity
ISO
EXP
geldanamycin inhibits the reaction [Nicotine results in increased activity of CASP3 protein]; MK-886 inhibits the reaction [Nicotine results in decreased expression of CASP3 protein]; Nicotine inhibits the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein]; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CASP3 protein modified form]; Nicotine inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]
Nicotine results in increased cleavage of CASP3 protein
Nicotine results in increased activity of CASP3 protein; Nicotine results in increased activity of CASP3 protein alternative form
Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein
Nicotine affects the expression of CASP3 mRNA
[Ethanol co-treated with Nicotine] results in increased expression of CASP3 protein; Nicotine inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein modified form
Nicotine results in increased expression of CASP3; Nicotine results in increased expression of CASP3 mRNA; Nicotine results in increased expression of CASP3 protein; Nicotine results in increased expression of CASP3 protein modified form
Nicotine results in decreased expression of CASP3 mRNA; Nicotine results in decreased expression of CASP3 protein
[Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP3 protein]; Resveratrol inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]; royal jelly inhibits the reaction [Nicotine results in increased expression of CASP3 mRNA]
Nicotine results in decreased activity of CASP3 protein
CTD PMID:11701223 PMID:12115584 PMID:12218695 PMID:15831280 PMID:16237857 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 affects expression EXP Nicotine affects the expression of CASP8 mRNA CTD PMID:20426880 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
decreases expression
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CASP9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP9 mRNA]
dexpanthenol inhibits the reaction [Nicotine results in increased expression of CASP9 protein]; Folic Acid inhibits the reaction [Nicotine results in increased expression of CASP9 protein]
Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein]
Nicotine results in decreased expression of CASP9 mRNA
CTD PMID:16949557 PMID:18676776 PMID:20230807 PMID:29972271 PMID:38229321 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase multiple interactions
decreases activity
increases activity
EXP
ISO
[acephate co-treated with methamidophos co-treated with Nicotine] results in increased activity of CAT protein; [Ethanol co-treated with Nicotine] results in decreased activity of CAT protein; [Ethanol co-treated with Nicotine] results in increased activity of CAT protein; Folic Acid inhibits the reaction [Nicotine results in decreased activity of CAT protein]
royal jelly inhibits the reaction [Nicotine results in decreased activity of CAT protein]
Nicotine results in increased activity of CAT protein
CTD PMID:10509436 PMID:10874619 PMID:10906423 PMID:11747978 PMID:15925865 More... NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav2 caveolin 2 decreases expression ISO Nicotine results in decreased expression of CAV2 mRNA CTD PMID:33640489 NCBI chr 4:46,582,681...46,590,058
Ensembl chr 4:45,616,712...45,624,244
JBrowse link
G Cbl Cbl proto-oncogene increases expression ISO Nicotine results in increased expression of CBL mRNA CTD PMID:18247414 NCBI chr 8:53,384,656...53,468,067
Ensembl chr 8:44,489,410...44,571,176
JBrowse link
G Cbln1 cerebellin 1 precursor increases expression ISO Nicotine results in increased expression of CBLN1 mRNA CTD PMID:21955143 NCBI chr19:35,782,151...35,785,960
Ensembl chr19:19,608,716...19,612,572
JBrowse link
G Cbx3 chromobox 3 increases expression ISO Nicotine results in increased expression of CBX3 mRNA CTD PMID:16949557 NCBI chr 4:81,876,155...81,889,912
Ensembl chr 4:80,546,010...80,559,283
Ensembl chr 4:80,546,010...80,559,283
JBrowse link
G Cbx5 chromobox 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CBX5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA] CTD PMID:20230807 NCBI chr 7:136,203,827...136,254,575
Ensembl chr 7:134,331,335...134,375,022
JBrowse link
G Ccdc136 coiled-coil domain containing 136 increases expression ISO Nicotine results in increased expression of CCDC136 mRNA CTD PMID:21955143 NCBI chr 4:58,963,196...58,992,962
Ensembl chr 4:57,997,853...58,027,646
JBrowse link
G Ccdc159 coiled-coil domain containing 159 increases expression ISO Nicotine results in increased expression of CCDC159 mRNA CTD PMID:23825647 NCBI chr 8:28,733,988...28,742,646
Ensembl chr 8:20,457,909...20,466,562
JBrowse link
G Ccdc167 coiled-coil domain containing 167 increases expression ISO Nicotine results in increased expression of CCDC167 mRNA CTD PMID:23825647 NCBI chr20:7,768,425...7,783,181
Ensembl chr20:7,751,782...7,781,613
JBrowse link
G Ccdc88a coiled coil domain containing 88A increases expression ISO Nicotine results in increased expression of CCDC88A mRNA CTD PMID:17456735 NCBI chr14:107,304,654...107,456,104
Ensembl chr14:103,103,513...103,252,368
JBrowse link
G Cck cholecystokinin decreases expression ISO Nicotine results in decreased expression of CCK mRNA CTD PMID:21955143 NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
decreases secretion
ISO
EXP
Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA]
Nicotine results in decreased expression of CCL2 mRNA; Nicotine results in decreased expression of CCL2 protein
Nicotine results in decreased secretion of CCL2 protein
CTD PMID:15135227 PMID:15976189 PMID:22093924 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO Nicotine results in increased expression of CCL5 mRNA CTD PMID:18247414 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Nicotine results in increased expression of CCN1 mRNA CTD PMID:17456735 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression EXP Nicotine results in increased expression of CCN2 protein CTD PMID:22691361 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO Nicotine results in increased expression of CCN5 mRNA CTD PMID:23825647 NCBI chr 3:172,910,670...172,922,064
Ensembl chr 3:152,491,220...152,502,636
JBrowse link
G Ccna2 cyclin A2 increases expression ISO Nicotine results in increased expression of CCNA2 protein CTD PMID:18448488 PMID:20106947 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 increases expression
multiple interactions
ISO Nicotine results in increased expression of CCNB1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNB1 mRNA]
CTD PMID:20106947 PMID:20230807 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
decreases expression
increases activity
ISO
EXP
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Curcumin inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of CCND1 protein]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of CCND1 protein]; Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein]; Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of CCND1 protein]
Nicotine results in decreased expression of CCND1 mRNA; Nicotine results in decreased expression of CCND1 protein
Nicotine results in increased activity of CCND1 promoter
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CCND1 mRNA]
Nicotine results in increased expression of CCND1 mRNA; Nicotine results in increased expression of CCND1 protein
CTD PMID:15574422 PMID:15983034 PMID:17135361 PMID:18448488 PMID:18805435 More... NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCND2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCND2 mRNA]
Nicotine results in decreased expression of CCND2 protein
CTD PMID:15231866 PMID:20230807 NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccne1 cyclin E1 multiple interactions
increases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of CCNE1 protein] CTD PMID:20061081 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Nicotine results in increased expression of CCNG2 mRNA CTD PMID:23416264 NCBI chr14:15,088,694...15,097,190
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Ccnl2 cyclin L2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNL2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNL2 mRNA] CTD PMID:20230807 NCBI chr 5:171,698,951...171,711,037
Ensembl chr 5:166,417,508...166,436,882
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO Nicotine results in increased expression of CCR5 mRNA CTD PMID:18247414 NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO Nicotine results in decreased expression of CCR6 mRNA CTD PMID:18247414 NCBI chr 1:55,022,037...55,055,857
Ensembl chr 1:52,474,168...52,498,603
JBrowse link
G Ccs copper chaperone for superoxide dismutase increases expression ISO Nicotine results in increased expression of CCS protein CTD PMID:16627626 NCBI chr 1:211,543,192...211,564,354
Ensembl chr 1:202,113,804...202,134,915
JBrowse link
G Cd151 CD151 molecule (Raph blood group) multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CD151 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CD151 mRNA] CTD PMID:20230807 NCBI chr 1:205,994,300...205,998,307
Ensembl chr 1:196,565,181...196,568,753
JBrowse link
G Cd4 Cd4 molecule decreases expression ISO Nicotine results in decreased expression of CD4 mRNA CTD PMID:18247414 NCBI chr 4:159,355,147...159,381,636
Ensembl chr 4:157,668,878...157,695,191
JBrowse link
G Cd44 CD44 molecule multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CD44 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD44 mRNA] CTD PMID:20230807 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cd46 CD46 molecule increases expression ISO Nicotine results in increased expression of CD46 mRNA CTD PMID:16949557 NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Cd59b CD59b molecule increases expression ISO Nicotine results in increased expression of CD59 mRNA CTD PMID:18247414 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP [Nicotine results in increased abundance of Cotinine] which results in increased expression of CD68 mRNA CTD PMID:29617909 NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Cd86 CD86 molecule increases expression EXP Nicotine results in increased expression of CD86 mRNA CTD PMID:27782041 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cd9 CD9 molecule multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CD9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD9 mRNA] CTD PMID:20230807 NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:158,256,328...158,289,222
JBrowse link
G Cdc25a cell division cycle 25A multiple interactions ISO Nicotine inhibits the reaction [E2F4 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC25A promoter] CTD PMID:16862215 NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdc42 cell division cycle 42 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDC42 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CDC42 mRNA] CTD PMID:20230807 NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Cdc6 cell division cycle 6 multiple interactions ISO Nicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC6 promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC6 promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr10:84,360,361...84,374,239
Ensembl chr10:83,864,638...83,878,011
JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression
ISO MK-886 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]; U 0126 inhibits the reaction [Nicotine results in decreased expression of CDH1 mRNA]
[Nicotine co-treated with Quartz] results in increased expression of CDH1 protein
Nicotine results in decreased expression of CDH1 mRNA; Nicotine results in decreased expression of CDH1 protein
CTD PMID:18844224 PMID:20061081 PMID:23219715 PMID:36868510 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh11 cadherin 11 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDH11 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA] CTD PMID:20230807 NCBI chr19:2,152,961...2,312,140
Ensembl chr19:2,148,458...2,304,272
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO [Nicotine co-treated with Quartz] results in increased expression of CDH2 protein; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of CDH2 protein] CTD PMID:36868510 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of CDK1 protein
CDK1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 affects the reaction [Nicotine results in increased expression of CDK1 protein]
CTD PMID:35929799 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk13 cyclin-dependent kinase 13 increases expression ISO Nicotine results in increased expression of CDK13 mRNA CTD PMID:16949557 NCBI chr17:51,945,975...52,040,218
Ensembl chr17:47,251,163...47,341,721
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO CDK2 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein] CTD PMID:35929799 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO Bungarotoxins inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein]; Nicotine promotes the reaction [NFATC2 protein results in decreased expression of CDK4 protein]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]
Nicotine results in decreased expression of CDK4 mRNA; Nicotine results in decreased expression of CDK4 protein
CTD PMID:15231866 PMID:17135361 PMID:18805435 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
increases expression
ISO Nicotine promotes the reaction [CDK6 protein binds to CCND1 protein]
Nicotine results in increased expression of CDK6 mRNA
CTD PMID:16949557 PMID:18805435 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions
increases expression
ISO Nicotine results in decreased expression of CDKN1A protein
Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN1A mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN1A protein]
Nicotine results in increased expression of CDKN1A mRNA; Nicotine results in increased expression of CDKN1A protein
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1A protein]; Nicotine inhibits the reaction [Cisplatin results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [Gemcitabine results in increased expression of CDKN1A protein]; Nicotine inhibits the reaction [Paclitaxel results in increased expression of CDKN1A protein]
CTD PMID:16011614 PMID:16601104 PMID:18805435 PMID:20727180 PMID:30272249 More... NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression
multiple interactions
ISO Nicotine results in decreased expression of CDKN1B protein
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1B protein]; Nicotine results in increased expression of and results in increased stability of CDKN1B protein
CTD PMID:15231866 PMID:18805435 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN2A mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CDKN2A protein]
Nicotine results in increased expression of CDKN2A mRNA; Nicotine results in increased expression of CDKN2A protein
CTD PMID:32473187 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cds1 CDP-diacylglycerol synthase 1 increases splicing ISO Nicotine results in increased splicing of CDS1 mRNA alternative form CTD PMID:23825647 NCBI chr14:8,126,678...8,187,243
Ensembl chr14:7,820,351...7,882,681
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Nicotine results in increased expression of CEACAM1 mRNA CTD PMID:17997037 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
affects expression
increases expression
EXP
ISO
[Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPA protein
Nicotine affects the expression of CEBPA mRNA
Nicotine results in increased expression of CEBPA mRNA
CTD PMID:29617909 PMID:31622651 PMID:31972234 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of CEBPB mRNA
[Nicotine results in increased abundance of Cotinine] which results in increased expression of CEBPB mRNA
CTD PMID:18805435 PMID:29617909 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Celf6 CUGBP, Elav-like family member 6 increases expression EXP Nicotine results in increased expression of CELF6 mRNA CTD PMID:27782041 NCBI chr 8:68,870,902...68,901,863
Ensembl chr 8:59,975,088...60,005,041
JBrowse link
G Cenpe centromere protein E increases expression ISO Nicotine results in increased expression of CENPE mRNA CTD PMID:16949557 NCBI chr 2:226,310,970...226,369,636
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
G Cers6 ceramide synthase 6 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of CERS6 mRNA CTD PMID:28065790 NCBI chr 3:74,038,520...74,287,544
Ensembl chr 3:53,630,959...53,876,848
JBrowse link
G Cetn2 centrin 2 decreases expression ISO Nicotine results in decreased expression of CETN2 mRNA CTD PMID:17997037 NCBI chr  X:155,812,212...155,817,186
Ensembl chr  X:150,769,953...150,774,919
JBrowse link
G Cetn3 centrin 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CETN3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CETN3 mRNA] CTD PMID:20230807 NCBI chr 2:13,817,760...13,837,502
Ensembl chr 2:12,089,226...12,101,828
JBrowse link
G Cfap43 cilia and flagella associated protein 43 decreases expression ISO Nicotine results in decreased expression of CFAP43 mRNA CTD PMID:23825647 NCBI chr 1:256,566,558...256,653,816
Ensembl chr 1:246,625,262...246,712,443
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide increases expression ISO Nicotine results in increased expression of CGA mRNA CTD PMID:23825647 NCBI chr 5:54,283,109...54,295,464
Ensembl chr 5:49,487,068...49,499,191
JBrowse link
G Cgref1 cell growth regulator with EF hand domain 1 increases expression ISO Nicotine results in increased expression of CGREF1 mRNA CTD PMID:23825647 NCBI chr 6:31,151,795...31,163,801
Ensembl chr 6:25,431,799...25,443,852
JBrowse link
G Chat choline O-acetyltransferase decreases activity
increases activity
multiple interactions
EXP Nicotine results in decreased activity of CHAT protein
Nicotine results in increased activity of CHAT protein
Nicotine inhibits the reaction [Vanadium results in decreased expression of CHAT protein]; Nicotine promotes the reaction [Bucladesine results in increased expression of CHAT protein]
CTD PMID:20361958 PMID:21633116 PMID:22119111 PMID:30247698 NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Chd2 chromodomain helicase DNA binding protein 2 increases expression ISO Nicotine results in increased expression of CHD2 mRNA CTD PMID:16949557 NCBI chr 1:136,597,993...136,726,874
Ensembl chr 1:127,190,059...127,300,502
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form] CTD PMID:23907605 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Chga chromogranin A multiple interactions
increases activity
increases expression
ISO
EXP
CHGA protein alternative form inhibits the reaction [Nicotine results in increased activity of CHGA promoter]; Chlorisondamine inhibits the reaction [Nicotine results in increased activity of CHGA promoter]
Nicotine results in increased expression of CHGA mRNA
CTD PMID:1907749 PMID:12799369 NCBI chr 6:127,460,895...127,472,238
Ensembl chr 6:121,696,051...121,707,398
JBrowse link
G Chgb chromogranin B increases expression EXP Nicotine results in increased expression of CHGB mRNA; Nicotine results in increased expression of CHGB protein CTD PMID:1907749 NCBI chr 3:140,496,712...140,510,057
Ensembl chr 3:120,043,738...120,057,166
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions
affects binding
ISO PLAU inhibits the reaction [Nicotine binds to CHRNA1 protein] CTD PMID:19690163 NCBI chr 3:78,862,286...78,877,353
Ensembl chr 3:58,454,744...58,469,840
JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit increases expression EXP Nicotine results in increased expression of CHRNA10 mRNA CTD PMID:30959089 PMID:31846720 NCBI chr 1:165,898,932...165,905,348
Ensembl chr 1:156,487,279...156,491,476
JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit affects response to substance
multiple interactions
ISO
EXP
CHRNA2 gene mutant form affects the susceptibility to Nicotine
nicotine affects binding to Chrna2 protein; nicotine inhibits the reaction [epibatidine affects binding to Chrna2 protein] in rat retina
nicotine affects binding competes with [Epibatidine binds to Chrna2 protein]
Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]
CTD
RGD
PMID:9454827 PMID:19383498 PMID:16129735 PMID:15016836 RGD:2303195, RGD:2303194 NCBI chr15:44,517,862...44,534,144
Ensembl chr15:40,342,317...40,358,601
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit decreases expression
multiple interactions
increases activity
increases expression
affects response to substance
ISO
EXP
Nicotine results in decreased expression of CHRNA3 mRNA
nicotine affects binding [Epibatidine binds to Chrna3 protein]
Nicotine affects binding [Epibatidine binds to Chrna3 protein]
Nicotine results in increased activity of CHRNA3 protein
Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Nicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
Nicotine results in increased expression of CHRNA3 mRNA
CHRNA3 protein affects the susceptibility to Nicotine
CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]
CTD
RGD
PMID:9454827 PMID:10336510 PMID:11600638 PMID:12628473 PMID:15275829 More... RGD:2303195, RGD:2303194 NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects binding
multiple interactions
increases expression
decreases expression
increases response to substance
affects response to substance
ISO
EXP
Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]
nicotine affects binding to Chrna4 protein; nicotine inhibits the reaction [epibatidine affects binding to Chrna4 protein] in rat retina
nicotine affects binding to Chrna4 protein; nicotine competes with [Epibatidine binds to Chrna4 protein]
Nicotine results in increased expression of CHRNA4 mRNA; Nicotine results in increased expression of CHRNA4 protein
Nicotine results in decreased expression of CHRNA4 mRNA
Nicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]
1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of [CHRNA4 protein binds to CHRNB2 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of CHRNA4 mRNA]; imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; N-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased expression of [CHRNA4 protein binds to CHRNB2 protein]
[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with Nicotine] inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein]; cytisine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]; Nicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CHRNA4 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
CHRNA4 protein mutant form results in increased susceptibility to Nicotine
CHRNA4 gene polymorphism affects the susceptibility to Nicotine; CHRNA4 protein affects the susceptibility to Nicotine; CHRNA4 protein mutant form affects the susceptibility to Nicotine
[CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]
CTD
RGD
PMID:7756618 PMID:9336329 PMID:9454827 PMID:10336510 PMID:10377228 More... RGD:2303195, RGD:2303194 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit increases response to substance
increases expression
affects response to substance
decreases expression
multiple interactions
ISO CHRNA5 gene polymorphism results in increased susceptibility to Nicotine
Nicotine results in increased expression of CHRNA5 mRNA
CHRNA5 gene polymorphism affects the susceptibility to Nicotine
Nicotine results in increased expression of CHRNA5 mRNA; Nicotine results in increased expression of CHRNA5 protein
Nicotine results in decreased expression of CHRNA5 mRNA
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; alpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; alpha-conotoxin MII inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of HIF1A protein]; CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of VEGFA protein]; CHRNA5 protein affects the reaction [Nicotine results in increased expression of and results in increased cleavage of CASP1 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased expression of NLRP3 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL18 protein]; CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL1B protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; Go 6976 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CHRNA5 protein]
CTD PMID:9495872 PMID:12628473 PMID:18450646 PMID:18519132 PMID:24793809 More... NCBI chr 8:64,265,879...64,294,233
Ensembl chr 8:55,369,794...55,398,146
JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit decreases expression
affects binding
multiple interactions
increases expression
affects response to substance
ISO
EXP
Nicotine results in decreased expression of CHRNA6 mRNA
nicotine binds to Chrna6 protein
nicotine inhibits the reaction [alpha-Conotoxin MII binds to Chrna6]; nicotine inhibits the reaction [epibatidine binds to Chrna6].
Nicotine results in increased expression of CHRNA6 mRNA
Nicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]; Nicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]
CHRNA6 gene polymorphism affects the susceptibility to Nicotine
CTD
RGD
PMID:10734154 PMID:12628473 PMID:17227438 PMID:29293602 PMID:30959089 More... RGD:8549526, RGD:8549526 NCBI chr16:71,400,615...71,407,315
Ensembl chr16:64,697,741...64,704,441
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases response to substance
affects binding
increases expression
affects activity
increases activity
decreases expression
multiple interactions
affects response to substance
ISO
EXP
CHRNA7 protein mutant form results in increased susceptibility to Nicotine
nicotine affects binding of the neuronal nicotinic acetylcholine receptor Chrna7 in rat hippocampal neurons
Nicotine results in increased expression of CHRNA7 mRNA; Nicotine results in increased expression of CHRNA7 protein
Nicotine affects the activity of CHRNA7 protein
Nicotine results in increased activity of CHRNA7 protein
Nicotine results in decreased expression of CHRNA7 mRNA; Nicotine results in decreased expression of CHRNA7 protein
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which affects the susceptibility to Nicotine; [Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of CHRNA7 protein; [Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium; Nicotine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]; Nicotine inhibits the reaction [methyllycaconitine binds to CHRNA7 protein]; Nicotine results in increased expression of and results in increased phosphorylation of CHRNA7 protein
[Bungarotoxins results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine; [triethyl-(beta-4-stilbenoxyethyl)ammonium results in decreased activity of CHRNA7 protein] which results in decreased susceptibility to Nicotine
CHRNA7 gene polymorphism affects the susceptibility to Nicotine; CHRNA7 protein affects the susceptibility to Nicotine
Nicotine results in increased expression of CHRNA7; Nicotine results in increased expression of CHRNA7 mRNA; Nicotine results in increased expression of CHRNA7 protein
Nicotine results in increased activity of CHRNA7 protein; Nicotine results in increased activity of CHRNA7 protein mutant form
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium; Bungarotoxins inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; CHRNA3 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; CHRNA7 affects the reaction [Nicotine results in decreased expression of SLBP protein]; CHRNA7 affects the reaction [Nicotine results in increased expression of CDK1 protein]; CHRNA7 affects the reaction [Nicotine results in increased expression of CSNK2A1 protein]; CHRNA7 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of CHRNA5 protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; KN 62 inhibits the reaction [Nicotine results in increased expression of CHRNA7 protein]; MB327 analog promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; MB327 promotes the reaction [Nicotine affects the activity of CHRNA7 protein]; MB327 promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Nicotine binds to and results in increased activity of CHRNA7 protein]; methyllycaconitine promotes the reaction [[Nicotine results in increased activity of CHRNA7 protein] which results in increased transport of Calcium]; Nicotine binds to and results in increased activity of CHRNA7 protein; Nicotine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine results in increased expression of and results in increased phosphorylation of CHRNA7 protein; Pyridinium Compounds analog promotes the reaction [Nicotine results in increased activity of CHRNA7 protein]
CTD
RGD
PMID:9336329 PMID:9495872 PMID:10082212 PMID:10216184 PMID:10942032 More... RGD:1600992 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit increases expression
multiple interactions
ISO Nicotine results in increased expression of CHRNA9 mRNA
[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of CHRNA9 protein
CTD PMID:29486207 PMID:30259641 PMID:30959089 PMID:31846720 NCBI chr14:42,588,948...42,595,669
Ensembl chr14:42,235,226...42,242,192
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
increases expression
decreases expression
affects binding
affects response to substance
ISO
EXP
[CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [cytisine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
nicotine affects binding to Chrnb2 protein; nicotine inhibits the reaction [epibatidine affects binding to Chrnb2 protein] in rat retina
nicotine affects binding to Chrnb2 protein; nicotine competes with [Epibatidine binds to Chrnb2 protein]
Nicotine results in increased expression of CHRNB2 mRNA
1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of [CHRNA4 protein binds to CHRNB2 protein]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; N-(5-azido-6-chloropyridin-3-ylmethyl)-N'-methyl-N''-nitroguanidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]]; Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]; Nicotine results in increased expression of [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in decreased expression of CHRNB2 mRNA
Nicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein]; Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein]
Nicotine results in increased expression of CHRNB2 mRNA; Nicotine results in increased expression of CHRNB2 protein
CHRNB2 protein affects the susceptibility to Nicotine
CHRNB2 promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; cytisine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]; Nicotine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Nicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine]; Nicotine inhibits the reaction [Paraquat results in decreased expression of [CHRNA6 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]
CTD
RGD
PMID:7756618 PMID:9336329 PMID:10336510 PMID:10377228 PMID:10945867 More... RGD:2303195, RGD:2303194 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit increases expression
multiple interactions
EXP Nicotine results in increased expression of CHRNB3 mRNA
nicotine affects binding to Chrnb3 protein; nicotine inhibits the reaction [epibatidine affects binding to Chrnb3 protein] in rat retina
CTD
RGD
PMID:30959089 PMID:16129735 RGD:2303195 NCBI chr16:71,411,847...71,454,225
Ensembl chr16:64,714,169...64,751,360
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions
increases expression
increases activity
affects response to substance
ISO
EXP
Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]; Nicotine results in increased activity of [CHRNB4 protein binds to CHRNA4 protein]
Nicotine results in increased expression of CHRNB4 mRNA
Nicotine results in increased activity of CHRNB4 protein
Nicotine analog binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]; Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]
CHRNB4 protein affects the susceptibility to Nicotine
CTD PMID:9454827 PMID:11600638 PMID:15275829 PMID:15615518 PMID:19483072 More... NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Ciao1 cytosolic iron-sulfur assembly component 1 decreases expression EXP Nicotine results in decreased expression of CIAO1 mRNA CTD PMID:11478936 NCBI chr 3:134,913,639...134,919,244
Ensembl chr 3:114,458,655...114,467,009
JBrowse link
G Cib1 calcium and integrin binding 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CIB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CIB1 mRNA] CTD PMID:20230807 NCBI chr 1:143,587,591...143,593,153
Ensembl chr 1:134,178,331...134,213,423
JBrowse link
G Cidea cell death-inducing DFFA-like effector a decreases expression EXP Nicotine results in decreased expression of CIDEA mRNA CTD PMID:33091441 NCBI chr18:63,164,817...63,190,384
Ensembl chr18:60,894,874...60,920,481
JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO Nicotine results in increased expression of CIRBP mRNA CTD PMID:21955143 NCBI chr 7:10,184,515...10,189,623
Ensembl chr 7:9,424,178...9,538,818
JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CKMT1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CKMT1 mRNA] CTD PMID:20230807 NCBI chr 3:128,783,408...128,789,485
Ensembl chr 3:108,330,705...108,335,758
JBrowse link
G Ckmt2 creatine kinase, mitochondrial 2 decreases expression ISO Nicotine results in decreased expression of CKMT2 mRNA CTD PMID:16949557 NCBI chr 2:24,815,008...24,845,511
Ensembl chr 2:23,079,918...23,110,430
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B decreases expression ISO Nicotine results in decreased expression of CKS1B mRNA CTD PMID:18247414 NCBI chr 2:177,130,751...177,135,333
Ensembl chr 2:174,833,050...174,837,636
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 increases expression ISO Nicotine results in increased expression of CKS2 mRNA CTD PMID:16949557 NCBI chr17:13,722,360...13,727,519 JBrowse link
G Clca2 chloride channel accessory 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CLCA2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLCA2 mRNA] CTD PMID:20230807 NCBI chr 2:236,655,419...236,682,669
Ensembl chr 2:233,995,078...234,022,199
JBrowse link
G Clcc1 chloride channel CLIC-like 1 increases expression ISO Nicotine results in increased expression of CLCC1 mRNA CTD PMID:16949557 NCBI chr 2:198,984,455...199,015,015
Ensembl chr 2:196,296,393...196,326,913
JBrowse link
G Clcn3 chloride voltage-gated channel 3 increases expression ISO Nicotine results in increased expression of CLCN3 mRNA CTD PMID:16949557 NCBI chr16:34,138,004...34,210,984
Ensembl chr16:29,127,419...29,200,119
JBrowse link
G Cldn4 claudin 4 decreases expression
increases expression
ISO Nicotine results in decreased expression of CLDN4 protein
Nicotine results in increased expression of CLDN4 protein
CTD PMID:31783125 NCBI chr12:27,388,160...27,389,958
Ensembl chr12:21,751,331...21,753,436
JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression ISO Nicotine results in decreased expression of CLIC1 mRNA CTD PMID:16949557 NCBI chr20:3,769,522...3,778,367
Ensembl chr20:3,761,461...3,773,712
JBrowse link
G Clmp CXADR-like membrane protein increases expression ISO Nicotine results in increased expression of CLMP mRNA CTD PMID:23825647 NCBI chr 8:49,957,639...50,065,959
Ensembl chr 8:41,060,799...41,168,838
JBrowse link
G Clstn1 calsyntenin 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA] CTD PMID:20230807 NCBI chr 5:165,314,128...165,377,627
Ensembl chr 5:160,031,308...160,094,583
JBrowse link
G Cmtm5 CKLF-like MARVEL transmembrane domain containing 5 decreases expression ISO Nicotine results in decreased expression of CMTM5 mRNA CTD PMID:21955143 NCBI chr15:32,382,171...32,385,288
Ensembl chr15:28,412,624...28,415,287
JBrowse link
G Cnn2 calponin 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CNN2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CNN2 mRNA] CTD PMID:20230807 NCBI chr 7:10,363,141...10,370,312
Ensembl chr 7:9,712,516...9,719,656
JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance
increases expression
multiple interactions
ISO CNR1 protein affects the susceptibility to Nicotine
Nicotine results in increased expression of CNR1 mRNA
[rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to Nicotine
CTD PMID:12384171 PMID:16416159 PMID:21955143 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cntn1 contactin 1 multiple interactions
increases expression
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA] CTD PMID:12588870 PMID:16949557 NCBI chr 7:125,142,638...125,440,397
Ensembl chr 7:123,372,792...123,558,541
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL1A1 mRNA; NGF protein affects the reaction [Nicotine results in increased expression of COL1A1 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL1A1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; Nicotine promotes the reaction [Thioacetamide results in increased expression of COL1A1]
Nicotine results in increased expression of COL1A1 mRNA; Nicotine results in increased expression of COL1A1 protein
CTD PMID:20230807 PMID:28440100 PMID:33082140 PMID:33640489 PMID:34153408 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP
ISO
Nicotine promotes the reaction [Arginine results in increased expression of COL1A2 protein]
Nicotine promotes the reaction [Quartz results in increased expression of COL1A2 protein]
CTD PMID:34153408 PMID:36868510 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of COL2A1 mRNA; Nicotine results in decreased expression of COL2A1 protein
NLRP3 protein affects the reaction [Nicotine results in decreased expression of COL2A1 mRNA]
CTD PMID:29660438 PMID:31299270 PMID:34245815 PMID:39098741 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of COL3A1 mRNA
Nicotine promotes the reaction [Arginine results in increased expression of COL3A1 protein]
Nicotine results in increased expression of COL3A1 mRNA; Nicotine results in increased expression of COL3A1 protein
NGF protein affects the reaction [Nicotine results in increased expression of COL3A1 mRNA]
CTD PMID:33082140 PMID:34153408 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Col6a1 collagen type VI alpha 1 chain multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL6A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL6A1 mRNA] CTD PMID:20230807 NCBI chr20:11,905,690...11,924,111
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Cort cortistatin affects expression
decreases expression
EXP Nicotine affects the expression of CORT protein
Nicotine results in decreased expression of CORT protein
CTD PMID:22975262 PMID:26776438 PMID:28555334 NCBI chr 5:164,843,682...164,845,796 JBrowse link
G Cox7a2l cytochrome c oxidase subunit 7A2 like multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of COX7A2L mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7A2L mRNA] CTD PMID:20230807 NCBI chr 6:16,936,574...16,950,797
Ensembl chr 6:11,184,285...11,198,273
JBrowse link
G Cox7c cytochrome c oxidase subunit 7C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7C mRNA] CTD PMID:20230807 NCBI chr 2:18,577,145...18,579,170
Ensembl chr 2:16,840,837...16,843,760
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 decreases expression ISO Nicotine results in decreased expression of CRABP2 mRNA CTD PMID:16949557 NCBI chr 2:175,714,862...175,719,208
Ensembl chr 2:173,416,857...173,421,379
JBrowse link
G Crct1 cysteine-rich C-terminal 1 increases expression ISO Nicotine results in increased expression of CRCT1 mRNA CTD PMID:23825647 NCBI chr 2:181,329,392...181,330,877
Ensembl chr 2:178,634,092...178,634,394
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases expression
increases phosphorylation
decreases expression
ISO
EXP
CREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA]
Nicotine results in increased expression of CREB1 mRNA
Nicotine results in increased phosphorylation of CREB1 protein
CREB1 protein promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; Excitatory Amino Acid Antagonists inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; KN 93 inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Nicotine promotes the reaction [CREB1 protein modified form binds to RYR2 promoter]; Nifedipine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]; Ryanodine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein]
Nicotine results in decreased expression of CREB1 mRNA
CTD PMID:18247414 PMID:21113126 PMID:25847246 PMID:31945395 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Creb3 cAMP responsive element binding protein 3 increases expression ISO Nicotine results in increased expression of CREB3 mRNA CTD PMID:31945395 NCBI chr 5:62,613,652...62,619,019
Ensembl chr 5:57,817,832...57,824,390
JBrowse link
G Creb5 cAMP responsive element binding protein 5 increases expression ISO Nicotine results in increased expression of CREB5 mRNA CTD PMID:31945395 NCBI chr 4:83,723,587...84,124,786
Ensembl chr 4:82,393,730...82,790,325
JBrowse link
G Crebbp CREB binding protein increases expression ISO Nicotine results in increased expression of CREBBP mRNA CTD PMID:31945395 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Crh corticotropin releasing hormone decreases expression
increases expression
EXP
ISO
Nicotine results in decreased expression of CRH mRNA; Nicotine results in decreased expression of CRH protein
Nicotine results in increased expression of CRH protein
CTD PMID:21955143 PMID:22265867 PMID:23623838 PMID:28555334 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Cryab crystallin, alpha B decreases expression ISO Nicotine results in decreased expression of CRYAB mRNA CTD PMID:21955143 NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Cs citrate synthase multiple interactions ISO [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA CTD PMID:33091441 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:758,345...791,421
JBrowse link
G Csdc2 cold shock domain containing C2 decreases expression ISO Nicotine results in decreased expression of CSDC2 mRNA CTD PMID:21955143 NCBI chr 7:115,332,134...115,346,599
Ensembl chr 7:113,451,998...113,466,463
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases secretion
ISO Nicotine results in increased expression of and results in increased secretion of CSF2 protein; Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein] CTD PMID:9606035 PMID:18082304 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Csn2 casein beta multiple interactions ISO Nicotine results in decreased expression of and results in decreased secretion of CSN2 protein CTD PMID:31783125 NCBI chr14:20,601,824...20,609,061
Ensembl chr14:20,322,581...20,329,817
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 multiple interactions
increases expression
ISO CHRNA7 affects the reaction [Nicotine results in increased expression of CSNK2A1 protein]; CSNK2A1 affects the reaction [Nicotine results in decreased expression of SLBP protein]; CSNK2A1 affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein] CTD PMID:35929799 NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:140,709,991...140,756,696
JBrowse link
G Cst3 cystatin C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CST3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CST3 mRNA] CTD PMID:20230807 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:136,336,920...136,340,822
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
ISO Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of CTNNB1 mRNA]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of CTNNB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]
Nicotine results in increased expression of CTNNB1 mRNA; Nicotine results in increased expression of CTNNB1 protein
CTD PMID:33640489 PMID:35411647 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSB mRNA] CTD PMID:20230807 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsh cathepsin H increases expression ISO Nicotine results in increased expression of CTSH mRNA CTD PMID:23825647 NCBI chr 8:99,488,756...99,507,639
Ensembl chr 8:90,608,941...90,627,824
JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CTSL mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA] CTD PMID:20230807 NCBI chr17:770,104...776,266
Ensembl chr17:764,309...770,548
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Nicotine results in decreased expression of CXCL2 mRNA CTD PMID:18247414 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression
decreases secretion
increases expression
ISO Nicotine results in decreased expression of CXCL1 mRNA
Nicotine results in decreased secretion of CXCL1 protein
Nicotine results in increased expression of CXCL1 protein
CTD PMID:16254210 PMID:22093924 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression
increases expression
ISO Nicotine results in decreased expression of CXCR2 mRNA
Nicotine results in increased expression of CXCR2 mRNA
CTD PMID:18247414 PMID:20457658 NCBI chr 9:83,178,645...83,185,017
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO Nicotine results in increased expression of CXCR3 mRNA CTD PMID:20457658 NCBI chr  X:70,884,293...70,886,944
Ensembl chr  X:66,844,318...66,846,969
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions
increases expression
ISO [Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein]
Nicotine results in increased expression of CXCR4 mRNA; Nicotine results in increased expression of CXCR4 protein
CTD PMID:20457658 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression
increases secretion
affects localization
decreases secretion
ISO
EXP
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of CYCS protein]
Nicotine results in increased expression of CYCS protein
Nicotine results in increased secretion of CYCS protein
Folic Acid inhibits the reaction [Nicotine results in increased expression of CYCS protein]; Nicotine inhibits the reaction [[Calcium co-treated with Phosphates] affects the localization of CYCS protein]
Nicotine affects the localization of CYCS protein
Nicotine results in decreased secretion of CYCS protein
CTD PMID:11701223 PMID:15985439 PMID:18203686 PMID:29972271 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
decreases activity
multiple interactions
ISO
EXP
Nicotine results in decreased expression of CYP11A1 mRNA; Nicotine results in decreased expression of CYP11A1 protein
Nicotine results in decreased activity of CYP11A1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYP11A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein]
CTD PMID:20230807 PMID:21971485 PMID:22265867 PMID:24709674 PMID:28986172 More... NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression EXP Nicotine results in decreased expression of CYP11B1 mRNA CTD PMID:24709674 NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:106,838,590...106,845,004
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO
EXP
Nicotine results in decreased expression of CYP17A1 mRNA
Nicotine results in decreased expression of CYP17A1 mRNA; Nicotine results in decreased expression of CYP17A1 protein
CTD PMID:24709674 PMID:27782041 PMID:28986172 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression
multiple interactions
increases activity
EXP
ISO
Nicotine results in decreased expression of CYP19A1 mRNA; Nicotine results in decreased expression of CYP19A1 protein
bisphenol A promotes the reaction [Nicotine results in decreased expression of CYP19A1 protein]
Nicotine results in increased activity of CYP19A1 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein]
CTD PMID:30959089 PMID:32113805 PMID:35577041 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased expression of CYP1A1 mRNA; Nicotine results in increased expression of CYP1A1 protein
bisphenol A promotes the reaction [Nicotine results in decreased expression of CYP1A1 protein]
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of CYP1A1 protein]; CYP1A1 protein affects the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; SB 203580 inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]; SR 11302 inhibits the reaction [Nicotine results in increased expression of CYP1A1 mRNA]
CTD PMID:11849738 PMID:22498344 PMID:34171359 PMID:35577041 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression
decreases activity
ISO
EXP
Nicotine results in increased expression of CYP1A2 protein
Nicotine results in decreased expression of CYP1A2 mRNA
Nicotine results in decreased activity of CYP1A2 protein
CTD PMID:11849738 PMID:15916432 PMID:26463278 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression
multiple interactions
EXP Nicotine results in decreased expression of CYP1B1 protein
bisphenol A promotes the reaction [Nicotine results in decreased expression of CYP1B1 protein]
CTD PMID:35577041 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression ISO Nicotine results in decreased expression of CYP26A1 mRNA; Nicotine results in decreased expression of CYP26A1 protein CTD PMID:21371177 NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression
multiple interactions
decreases activity
increases metabolic processing
EXP
ISO
Nicotine results in increased expression of CYP2A1 mRNA
Nicotine inhibits the reaction [[CYP2A13 protein results in increased metabolism of N'-nitrosonornicotine] which results in increased abundance of 4-hydroxy-1-(3-pyridyl)-1-butanone]; Nicotine inhibits the reaction [CYP2A13 protein results in increased susceptibility to Aflatoxin B1]
Nicotine results in decreased activity of CYP2A13 protein
CYP2A13 protein results in increased metabolism of Nicotine
CTD PMID:22743290 PMID:22934830 PMID:27567546 NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 increases expression
increases hydroxylation
EXP Nicotine results in increased expression of CYP2A2 mRNA
CYP2A6 protein results in increased hydroxylation of Nicotine
CTD PMID:12919726 PMID:22934830 NCBI chr 1:91,391,492...91,417,158
Ensembl chr 1:82,263,833...82,289,487
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression EXP Nicotine results in increased expression of CYP2A3 mRNA CTD PMID:14972772 PMID:22934830 NCBI chr 1:91,299,584...91,307,650
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases metabolic processing
multiple interactions
increases expression
EXP CYP2B1 protein results in increased metabolism of Nicotine
[Nicotine co-treated with 2,2',3,5',6-pentachlorobiphenyl] results in increased expression of CYP2B1 mRNA; [Nicotine results in increased expression of CYP2B1 protein] which results in increased abundance of Cotinine; [Nicotine results in increased expression of CYP2B1 protein] which results in increased metabolism of Nicotine; Nicotine results in increased expression of and results in increased activity of CYP2B1 protein
Nicotine results in increased expression of CYP2B1 mRNA; Nicotine results in increased expression of CYP2B1 protein
CTD PMID:10799646 PMID:14972772 PMID:20599831 PMID:26463278 NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing
affects oxidation
increases oxidation
multiple interactions
ISO CYP2B6 protein results in increased metabolism of Nicotine
CYP2B6 gene polymorphism affects the oxidation of Nicotine
CYP2B6 protein results in increased oxidation of Nicotine
CYP2B6 gene polymorphism affects the reaction [CYP2A6 protein results in increased metabolism of Nicotine]
CTD PMID:12488541 PMID:18004205 PMID:30906561 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases expression
ISO Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 mRNA]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 protein]
Nicotine results in increased expression of CYP2D22 mRNA; Nicotine results in increased expression of CYP2D22 protein
CTD PMID:19594327 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP Nicotine results in increased expression of CYP2E1 protein CTD PMID:16434548 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP
ISO
[Nicotine co-treated with 2,2',3,5',6-pentachlorobiphenyl] results in increased expression of CYP3A2 mRNA
[Nicotine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA
CTD PMID:12851153 PMID:26463278 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases expression ISO Nicotine results in increased expression of CYP4F3 mRNA CTD PMID:23825647 NCBI chr16:17,797,558...17,838,958
Ensembl chr16:17,707,317...17,804,940
JBrowse link
G Dbh dopamine beta-hydroxylase multiple interactions
increases expression
ISO [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of DBH mRNA] CTD PMID:17498763 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Dbi diazepam binding inhibitor increases expression ISO nicotine increases expression of Dbi mRNA and protein in cerebral cortex and cortical neurons. RGD PMID:11750077 RGD:408356485 NCBI chr13:33,794,231...33,802,632
Ensembl chr13:31,206,988...31,268,693
JBrowse link
G Dcaf16 DDB1 and CUL4 associated factor 16 increases expression ISO Nicotine results in increased expression of DCAF16 mRNA CTD PMID:16949557 NCBI chr14:69,662,173...69,662,557 JBrowse link
G Ddb1 damage-specific DNA binding protein 1 decreases expression ISO Nicotine results in decreased expression of DDB1 mRNA CTD PMID:16949557 NCBI chr 1:216,677,810...216,703,605
Ensembl chr 1:207,252,890...207,278,676
JBrowse link
G Ddhd2 DDHD domain containing 2 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of DDHD2 mRNA CTD PMID:28065790 NCBI chr16:73,022,136...73,051,746
Ensembl chr16:66,319,466...66,349,023
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO
EXP
Nicotine inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA]
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of DDIT3 protein]
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DDIT3 protein]
CTD PMID:11592233 PMID:28082123 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Nicotine results in increased expression of DDIT4 mRNA CTD PMID:17456735 PMID:23825647 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Ddx17 DEAD-box helicase 17 increases expression ISO Nicotine results in increased expression of DDX17 mRNA CTD PMID:16949557 NCBI chr 7:112,971,522...112,989,747
Ensembl chr 7:111,089,445...111,109,193
JBrowse link
G Dedd death effector domain-containing decreases expression ISO Nicotine results in decreased expression of DEDD mRNA CTD PMID:18247414 NCBI chr13:86,286,341...86,301,789
Ensembl chr13:83,756,108...83,769,332
JBrowse link
G Defb23 defensin beta 23 decreases expression ISO Nicotine results in decreased expression of DEFB129 mRNA CTD PMID:23825647 NCBI chr 3:161,383,615...161,390,685
Ensembl chr 3:140,923,474...140,927,686
JBrowse link
G Dffb DNA fragmentation factor subunit beta decreases expression ISO Nicotine results in decreased expression of DFFB mRNA CTD PMID:18247414 NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:164,522,463...164,534,628
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO Nicotine results in decreased expression of DHCR24 mRNA CTD PMID:21955143 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Dhfr dihydrofolate reductase multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA] CTD PMID:12588870 NCBI chr 2:25,320,895...25,346,004
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Dhps deoxyhypusine synthase decreases expression ISO Nicotine results in decreased expression of DHPS mRNA CTD PMID:16949557 NCBI chr19:39,987,328...39,991,418
Ensembl chr19:23,082,448...23,086,881
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases expression ISO Nicotine results in increased expression of DHRS3 mRNA CTD PMID:23825647 NCBI chr 5:162,031,853...162,065,655
Ensembl chr 5:156,747,962...156,782,417
JBrowse link
G Dhx36 DEAH-box helicase 36 increases expression ISO Nicotine results in increased expression of DHX36 mRNA CTD PMID:17997037 NCBI chr 2:149,006,089...149,044,192
Ensembl chr 2:146,856,469...146,894,572
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
decreases methylation
ISO
EXP
Nicotine results in decreased expression of DLG4 mRNA
Nicotine results in decreased methylation of DLG4 gene
CTD PMID:21955143 PMID:28555334 PMID:32994467 NCBI chr10:55,239,397...55,267,780
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJA1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJA1 mRNA] CTD PMID:20230807 NCBI chr 5:60,638,404...60,649,315
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJB9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJB9 mRNA] CTD PMID:20230807 NCBI chr 6:66,997,842...67,007,371
Ensembl chr 6:61,269,913...61,275,063
JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal decreases expression ISO Nicotine results in decreased expression of DNASE2 mRNA CTD PMID:18247414 NCBI chr19:40,149,505...40,152,225
Ensembl chr19:23,244,664...23,247,376
JBrowse link
G Dnm1l dynamin 1-like increases expression ISO Nicotine results in increased expression of DNM1L protein CTD PMID:21554491 NCBI chr11:98,084,049...98,135,663
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression
multiple interactions
EXP Nicotine results in decreased expression of DNMT1 mRNA
Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in decreased expression of DNMT1 mRNA]
CTD PMID:28555334 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA] CTD PMID:20230807 NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:46,962,243...47,043,901
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions
decreases expression
EXP
ISO
[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Nicotine
Nicotine results in decreased expression of DRD1 mRNA
CTD PMID:1833784 PMID:21955143 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
decreases response to substance
EXP [Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Nicotine
DRD2 mRNA results in decreased susceptibility to Nicotine
CTD PMID:1833784 PMID:24239691 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 increases expression ISO Nicotine results in increased expression of DRD3 protein CTD PMID:31945395 NCBI chr11:70,385,586...70,437,793
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Dtymk deoxythymidylate kinase decreases expression ISO Nicotine results in decreased expression of DTYMK mRNA CTD PMID:16949557 NCBI chr 9:101,762,899...101,771,733
Ensembl chr 9:94,315,552...94,324,870
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Nicotine results in increased expression of DUSP1 mRNA CTD PMID:17456735 NCBI chr10:17,184,853...17,187,646 JBrowse link
G Dusp11 dual specificity phosphatase 11 decreases expression ISO Nicotine results in decreased expression of DUSP11 mRNA CTD PMID:17456735 NCBI chr 4:119,928,533...119,942,643
Ensembl chr 4:118,368,053...118,385,181
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO Nicotine results in increased expression of DUSP6 mRNA CTD PMID:17456735 PMID:21955143 NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Dvl2 dishevelled segment polarity protein 2 decreases expression
multiple interactions
increases expression
ISO Nicotine results in decreased expression of DVL2 mRNA
Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of DVL2 mRNA]; Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of DVL2 protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of DVL2 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of DVL2 protein]
Nicotine results in increased expression of DVL2 mRNA; Nicotine results in increased expression of DVL2 protein
CTD PMID:16949557 PMID:33640489 PMID:35411647 NCBI chr10:55,222,245...55,231,506
Ensembl chr10:54,723,411...54,732,820
JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 increases expression ISO Nicotine results in increased expression of DYNC1LI2 mRNA CTD PMID:16949557 NCBI chr19:538,207...561,110
Ensembl chr19:531,812...554,670
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions
increases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of E2F1 protein]; Nicotine promotes the reaction [E2F1 protein binds to BIRC5 promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F1 protein binds to CDC6 promoter] CTD PMID:16601104 PMID:16862215 PMID:20061081 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G E2f2 E2F transcription factor 2 multiple interactions ISO Nicotine promotes the reaction [E2F2 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F2 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr 5:153,682,789...153,706,087
Ensembl chr 5:148,399,642...148,421,217
JBrowse link
G E2f3 E2F transcription factor 3 multiple interactions ISO Nicotine promotes the reaction [E2F3 protein binds to CDC25A promoter]; Nicotine promotes the reaction [E2F3 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,601,830...34,676,253
JBrowse link
G E2f4 E2F transcription factor 4 multiple interactions ISO Nicotine inhibits the reaction [E2F4 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr19:50,084,335...50,091,731
Ensembl chr19:33,174,410...33,181,806
JBrowse link
G E2f5 E2F transcription factor 5 multiple interactions ISO Nicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr 2:88,718,567...88,734,143
Ensembl chr 2:86,997,332...87,012,990
JBrowse link
G Ebf2 EBF transcription factor 2 increases expression EXP Nicotine results in increased expression of EBF2 mRNA CTD PMID:35026373 NCBI chr15:45,610,949...45,809,828
Ensembl chr15:41,435,509...41,634,403
JBrowse link
G Ecm1 extracellular matrix protein 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ECM1 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ECM1 mRNA] CTD PMID:20230807 NCBI chr 2:185,976,439...185,981,656
Ensembl chr 2:183,287,322...183,292,671
JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of EDN1 mRNA; Nicotine results in increased expression of EDN1 protein
MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of EDN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]
CTD PMID:33082140 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednra endothelin receptor type A decreases expression ISO Nicotine results in decreased expression of EDNRA mRNA CTD PMID:18247414 NCBI chr19:47,137,360...47,207,961
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Ednrb endothelin receptor type B increases activity EXP Nicotine results in increased activity of EDNRB protein CTD PMID:21316381 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of EEF2 protein modified form
[Nicotine results in increased expression of UBA2 protein] which results in increased sumoylation of EEF2 protein
CTD PMID:21554491 NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:8,533,116...8,559,183
JBrowse link
G Efhd1 EF-hand domain family, member D1 decreases expression ISO Nicotine results in decreased expression of EFHD1 mRNA CTD PMID:21955143 NCBI chr 9:95,386,155...95,432,800
Ensembl chr 9:87,938,284...87,984,917
JBrowse link
G Efna2 ephrin A2 increases expression ISO Nicotine results in increased expression of EFNA2 mRNA CTD PMID:23825647 NCBI chr 7:10,167,091...10,177,719
Ensembl chr 7:9,516,429...9,527,061
JBrowse link
G Efnb3 ephrin B3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EFNB3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EFNB3 mRNA] CTD PMID:20230807 NCBI chr10:54,773,282...54,780,727
Ensembl chr10:54,274,506...54,280,471
JBrowse link
G Egfr epidermal growth factor receptor decreases expression
increases phosphorylation
multiple interactions
EXP
ISO
Nicotine results in decreased expression of EGFR mRNA
Nicotine results in increased phosphorylation of EGFR protein
AG 1879 inhibits the reaction [Nicotine results in increased phosphorylation of EGFR protein]
CTD PMID:11478936 PMID:14569062 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 increases expression
decreases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of EGR1 mRNA; Nicotine results in increased expression of EGR1 protein
Nicotine results in decreased expression of EGR1 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EGR1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EGR1 mRNA]
[triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]] which results in decreased expression of FGF2 mRNA; EGR1 protein inhibits the reaction [triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 protein]; Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of EGR1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein]
CTD PMID:17456735 PMID:17997037 PMID:20230807 PMID:21955143 PMID:22198237 More... NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr2 early growth response 2 increases expression ISO Nicotine results in increased expression of EGR2 mRNA CTD PMID:17456735 NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,051,277...21,055,562
JBrowse link
G Egr3 early growth response 3 decreases expression ISO Nicotine results in decreased expression of EGR3 mRNA CTD PMID:21955143 NCBI chr15:51,560,482...51,565,778
Ensembl chr15:45,150,567...45,154,627
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 increases expression ISO Nicotine results in increased expression of EIF2AK2 mRNA CTD PMID:16949557 NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
EXP Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein]; ursodoxicoltaurine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26803847 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B subunit delta multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF2B4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF2B4 mRNA] CTD PMID:20230807 NCBI chr 6:30,903,148...30,908,803
Ensembl chr 6:25,183,186...25,188,829
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP Nicotine results in increased phosphorylation of EIF2S1 protein CTD PMID:26803847 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA]
EIF4E protein affects the reaction [Nicotine results in increased expression of BCL2 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of CCND1 protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of MYC protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of VEGFA protein]; Nicotine promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]
CTD PMID:20230807 PMID:30836163 NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif4e3 eukaryotic translation initiation factor 4E family member 3 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of EIF4E3 mRNA CTD PMID:37951547 NCBI chr 4:133,709,802...133,858,398
Ensembl chr 4:132,258,502...132,301,808
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of EIF4EBP1 protein; Nicotine promotes the reaction [EIF4EBP1 protein binds to EIF4E protein]; Nicotine results in increased expression of and results in increased phosphorylation of EIF4EBP1 protein CTD PMID:12511591 PMID:30836163 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EIF5 mRNA] CTD PMID:20230807 NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:130,589,143...130,597,656
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions
increases phosphorylation
ISO
EXP
Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein] CTD PMID:29486207 NCBI chr  X:3,692,367...3,709,252
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Emc3 ER membrane protein complex subunit 3 decreases expression ISO Nicotine results in decreased expression of EMC3 mRNA CTD PMID:17997037 NCBI chr 4:148,218,686...148,234,595
Ensembl chr 4:146,663,067...146,679,029
JBrowse link
G Emcn endomucin increases expression ISO Nicotine results in increased expression of EMCN mRNA CTD PMID:17456735 NCBI chr 2:228,564,445...228,644,370
Ensembl chr 2:225,891,100...225,970,929
JBrowse link
G Eml4 EMAP like 4 multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA]; Mecamylamine promotes the reaction [Nicotine results in decreased expression of EML4 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA] CTD PMID:12588870 NCBI chr 6:16,972,054...17,087,365
Ensembl chr 6:11,219,566...11,334,879
JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Nicotine results in increased expression of EMP1 mRNA CTD PMID:23825647 NCBI chr 4:169,931,537...169,964,366
Ensembl chr 4:168,212,861...168,232,904
JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression ISO Nicotine results in decreased expression of ENC1 mRNA CTD PMID:17997037 NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:28,550,464...28,562,713
JBrowse link
G Eng endoglin decreases expression ISO Nicotine results in decreased expression of ENG mRNA CTD PMID:17456735 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Eno1 enolase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA] CTD PMID:20230807 NCBI chr 5:166,002,867...166,014,252
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336
JBrowse link
G Entpd3 ectonucleoside triphosphate diphosphohydrolase 3 increases expression ISO Nicotine results in increased expression of ENTPD3 mRNA CTD PMID:23825647 NCBI chr 8:129,124,540...129,155,528
Ensembl chr 8:120,247,121...120,277,943
JBrowse link
G Epha3 Eph receptor A3 decreases expression ISO Nicotine results in decreased expression of EPHA3 mRNA CTD PMID:18247414 NCBI chr11:14,585,041...14,920,721
Ensembl chr11:1,140,985...1,473,900
JBrowse link
G Ephb3 Eph receptor B3 decreases expression ISO Nicotine results in decreased expression of EPHB3 mRNA CTD PMID:18247414 NCBI chr11:93,345,098...93,363,775
Ensembl chr11:79,840,668...79,859,370
JBrowse link
G Epo erythropoietin increases expression ISO Nicotine results in increased expression of EPO mRNA CTD PMID:18247414 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA] CTD PMID:20230807 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Erp44 endoplasmic reticulum protein 44 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ERP44 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERP44 mRNA] CTD PMID:20230807 NCBI chr 5:67,313,245...67,406,207
Ensembl chr 5:62,516,551...62,610,761
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 increases expression ISO Nicotine results in increased expression of ERRFI1 mRNA CTD PMID:17456735 NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:161,323,998...161,337,282
JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Nicotine results in decreased expression of ESR1 mRNA CTD PMID:27552315 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Etfa electron transfer flavoprotein subunit alpha multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ETFA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ETFA mRNA] CTD PMID:20230807 NCBI chr 8:64,731,192...64,787,965
Ensembl chr 8:55,835,134...55,891,969
JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression ISO Nicotine results in decreased expression of ETFB mRNA CTD PMID:17997037 NCBI chr 1:102,988,499...103,002,663
Ensembl chr 1:93,851,858...93,866,068
JBrowse link
G Ezr ezrin multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EZR mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA]
Nicotine results in increased expression of EZR mRNA
CTD PMID:18247414 PMID:20230807 NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G F2 coagulation factor II, thrombin increases expression ISO Nicotine results in increased expression of F2 mRNA CTD PMID:18805435 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 increases expression EXP Nicotine results in increased expression of F2RL2 mRNA CTD PMID:27782041 NCBI chr 2:28,706,766...28,711,808
Ensembl chr 2:26,972,054...26,977,098
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Nicotine results in increased expression of F3 mRNA CTD PMID:17997037 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fah fumarylacetoacetate hydrolase increases expression ISO Nicotine results in increased expression of FAH mRNA CTD PMID:23825647 NCBI chr 1:147,957,931...147,980,708
Ensembl chr 1:138,548,834...138,571,505
JBrowse link
G Fam107a family with sequence similarity 107, member A decreases expression ISO Nicotine results in decreased expression of FAM107A mRNA CTD PMID:21955143 NCBI chr15:19,038,726...19,060,644
Ensembl chr15:16,607,205...16,630,396
JBrowse link
G Fam120a family with sequence similarity 120 member A decreases expression ISO Nicotine results in decreased expression of FAM120A mRNA CTD PMID:17997037 NCBI chr17:15,890,151...15,981,337
Ensembl chr17:15,684,233...15,774,964
JBrowse link
G Fam83f family with sequence similarity 83, member F increases expression ISO Nicotine results in increased expression of FAM83F mRNA CTD PMID:23825647 NCBI chr 7:114,091,356...114,120,640
Ensembl chr 7:112,211,164...112,240,452
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO
EXP
Nicotine results in increased expression of FAS mRNA; Nicotine results in increased expression of FAS protein CTD PMID:18203686 PMID:20383341 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand affects expression
increases expression
EXP
ISO
Nicotine affects the expression of FASLG mRNA
Nicotine results in increased expression of FASLG mRNA; Nicotine results in increased expression of FASLG protein
Nicotine results in increased expression of FASLG protein alternative form
CTD PMID:18203686 PMID:18247414 PMID:19896492 PMID:20383341 PMID:20426880 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase increases expression
affects expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of FASN mRNA; Nicotine results in increased expression of FASN protein
Nicotine affects the expression of FASN mRNA
Nicotine promotes the reaction [NR1H3 protein binds to FASN promoter]
CTD PMID:24368177 PMID:29155039 PMID:31622651 PMID:31972234 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fat1 FAT atypical cadherin 1 increases expression ISO Nicotine results in increased expression of FAT1 mRNA CTD PMID:16949557 NCBI chr16:53,909,759...54,029,175
Ensembl chr16:47,177,248...47,296,107
JBrowse link
G Fat2 FAT atypical cadherin 2 increases expression ISO Nicotine results in increased expression of FAT2 mRNA CTD PMID:23825647 NCBI chr10:39,864,765...39,957,027
Ensembl chr10:39,364,073...39,456,216
JBrowse link
G Fbn1 fibrillin 1 increases expression ISO Nicotine results in increased expression of FBN1 mRNA CTD PMID:17456735 NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fbxl12 F-box and leucine-rich repeat protein 12 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FBXL12 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FBXL12 mRNA] CTD PMID:20230807 NCBI chr 8:27,453,042...27,459,136
Ensembl chr 8:19,160,352...19,183,607
JBrowse link
G Fbxw5 F-box and WD repeat domain containing 5 decreases expression ISO Nicotine results in decreased expression of FBXW5 mRNA CTD PMID:17997037 NCBI chr 3:28,720,670...28,725,237
Ensembl chr 3:8,322,543...8,327,092
JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 increases expression
multiple interactions
decreases expression
ISO Nicotine results in increased expression of FEZ1 mRNA
alpha-cobratoxin promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA alternative form]; Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA]
CTD PMID:12588870 NCBI chr 8:44,733,288...44,778,519
Ensembl chr 8:36,544,535...36,589,683
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases expression
decreases expression
increases secretion
ISO
EXP
[triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]] which results in decreased expression of FGF2 mRNA; EGR1 protein inhibits the reaction [triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]]; Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine promotes the reaction [EGR1 protein binds to FGF2 promoter]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased secretion of FGF2 protein]
Nicotine results in increased expression of FGF2 mRNA; Nicotine results in increased expression of FGF2 protein
Mecamylamine inhibits the reaction [Nicotine results in increased expression of FGF2 mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of FGF2 mRNA]
Nicotine results in decreased expression of FGF2 protein
CTD PMID:9503263 PMID:9832142 PMID:14732461 PMID:15465631 PMID:16365874 More... NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO Nicotine promotes the reaction [Quartz results in increased expression of FGF7 protein] CTD PMID:36868510 NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:113,281,283...113,332,929
JBrowse link
G Flrt2 fibronectin leucine rich transmembrane protein 2 increases expression ISO Nicotine results in increased expression of FLRT2 mRNA CTD PMID:23825647 NCBI chr 6:120,507,998...120,603,133
Ensembl chr 6:114,777,599...114,872,785
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases expression ISO Nicotine results in decreased expression of FLT3 mRNA CTD PMID:18247414 NCBI chr12:12,660,035...12,735,584
Ensembl chr12:7,623,930...7,699,474
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of Nicotine CTD PMID:12504349 NCBI chr13:77,838,899...77,868,869
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Fn1 fibronectin 1 decreases expression
multiple interactions
increases expression
ISO Nicotine results in decreased expression of FN1 mRNA
MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of FN1 mRNA]; Nicotine promotes the reaction [Quartz results in increased expression of FN1 protein]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]
Nicotine results in increased expression of FN1 mRNA; Nicotine results in increased expression of FN1 protein
CTD PMID:18247414 PMID:18844224 PMID:33082140 PMID:36868510 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Folr1 folate receptor alpha increases expression ISO Nicotine results in increased expression of FOLR1 mRNA CTD PMID:19616087 NCBI chr 1:165,631,462...165,650,430
Ensembl chr 1:156,219,460...156,230,667
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation
affects expression
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased expression of FOS; Nicotine results in increased expression of FOS mRNA; Nicotine results in increased expression of FOS protein
Nicotine results in increased phosphorylation of FOS protein
Nicotine deficiency affects the expression of FOS protein
Acetaldehyde promotes the reaction [Nicotine results in increased expression of FOS mRNA]; Saponins inhibits the reaction [Nicotine results in increased expression of FOS protein]
Nicotine results in decreased expression of FOS mRNA
[U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; SB 203580 inhibits the reaction [Nicotine results in increased phosphorylation of FOS protein]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS]
CTD PMID:11425648 PMID:15857624 PMID:16251992 PMID:16690037 PMID:17003101 More... NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression
increases expression
ISO
EXP
Nicotine results in increased expression of FOSB mRNA
nicotine increases expression of Fosb protein in nucleus accumbens and dentate gyrus of hippocampal formation
nicotine increases expression of FosB protein in nucleus accumbens and caudate-putamen
Nicotine results in increased expression of FOSB protein
CTD
RGD
PMID:16949557 PMID:17324382 PMID:17456735 PMID:17333132 PMID:17468183 RGD:407571683, RGD:401900124 NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of FOXO1 protein CTD PMID:12511591 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Foxp1 forkhead box P1 decreases expression ISO Nicotine results in decreased expression of FOXP1 mRNA CTD PMID:21955143 NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:131,564,756...132,112,258
JBrowse link
G Foxp3 forkhead box P3 decreases expression ISO Nicotine results in decreased expression of FOXP3 protein CTD PMID:31629012 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression ISO Nicotine results in decreased expression of SNL mRNA CTD PMID:18247414 NCBI chr12:16,710,601...16,723,734
Ensembl chr12:11,597,048...11,610,211
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Nicotine results in decreased expression of FSHB mRNA; Nicotine results in decreased expression of FSHB protein CTD PMID:20498001 PMID:28986172 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Fxyd1 FXYD domain-containing ion transport regulator 1 increases expression ISO Nicotine results in increased expression of FXYD1 mRNA CTD PMID:17997037 NCBI chr 1:95,414,556...95,418,645
Ensembl chr 1:86,287,165...86,291,278
JBrowse link
G Fxyd7 FXYD domain-containing ion transport regulator 7 decreases expression ISO Nicotine results in decreased expression of FXYD7 mRNA CTD PMID:21955143 NCBI chr 1:95,405,071...95,414,407
Ensembl chr 1:86,277,678...86,286,954
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO LCK protein promotes the reaction [Nicotine results in increased phosphorylation of and results in increased activity of FYN protein]; Nicotine results in increased phosphorylation of and results in increased activity of FYN protein CTD PMID:17709503 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:42,766,369...42,959,911
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP Nicotine results in decreased activity of G6PD protein CTD PMID:20498001 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gab1 GRB2-associated binding protein 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GAB1 mRNA] CTD PMID:20230807 NCBI chr19:44,035,693...44,143,617
Ensembl chr19:27,131,262...27,239,236
JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 increases expression EXP Nicotine results in increased expression of GABRA3 mRNA CTD PMID:28339662 NCBI chr  X:155,301,979...155,543,870
Ensembl chr  X:150,261,607...150,501,559
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 increases expression EXP Nicotine results in increased expression of GABRA5 mRNA CTD PMID:28339662 NCBI chr 1:117,404,446...117,517,424
Ensembl chr 1:108,268,776...108,380,917
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 increases expression EXP Nicotine results in increased expression of GABRA6 mRNA CTD PMID:28339662 NCBI chr10:27,311,965...27,327,337
Ensembl chr10:26,810,423...26,825,769
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression ISO Nicotine results in increased expression of GABRG2 mRNA CTD PMID:21955143 NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression
decreases methylation
multiple interactions
EXP Nicotine results in increased expression of GAD1 mRNA; Nicotine results in increased expression of GAD1 protein
Nicotine results in decreased methylation of GAD1 promoter
Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of GAD1 mRNA]
CTD PMID:18312583 PMID:28555334 NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gad2 glutamate decarboxylase 2 decreases expression EXP Nicotine results in decreased expression of GAD2 mRNA CTD PMID:28555334 NCBI chr17:89,671,718...89,734,246
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Gal galanin and GMAP prepropeptide decreases expression ISO Nicotine results in decreased expression of GAL mRNA CTD PMID:21955143 NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:200,650,439...200,654,959
JBrowse link
G Gale UDP-galactose-4-epimerase decreases expression ISO Nicotine results in decreased expression of GALE mRNA CTD PMID:16949557 NCBI chr 5:153,477,420...153,481,926
Ensembl chr 5:148,194,791...148,198,388
JBrowse link
G Galk2 galactokinase 2 increases expression ISO Nicotine results in increased expression of GALK2 mRNA CTD PMID:17456735 NCBI chr 3:133,563,524...133,696,423
Ensembl chr 3:113,110,030...113,233,306
JBrowse link
G Gap43 growth associated protein 43 multiple interactions ISO [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAP43 protein] CTD PMID:23933227 NCBI chr11:71,882,131...71,975,799
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAPDH mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAPDH mRNA] CTD PMID:20230807 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gata2 GATA binding protein 2 multiple interactions
increases expression
ISO 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; Bungarotoxins inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 mRNA]; CHRNA7 protein affects the reaction [Nicotine results in increased expression of GATA2 protein]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; GATA2 protein affects the reaction [Nicotine results in increased expression of CHRNA7 protein]; manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; manumycin inhibits the reaction [Nicotine results in increased expression of GATA2 protein]; U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 mRNA]; U 0126 inhibits the reaction [Nicotine results in increased expression of GATA2 protein]
Nicotine results in increased expression of GATA2 mRNA; Nicotine results in increased expression of GATA2 protein
CTD PMID:18450646 NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions ISO [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA4 protein binds to SP1 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter] CTD PMID:24089524 NCBI chr15:41,635,572...41,707,252
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G Gata6 GATA binding protein 6 multiple interactions ISO [GATA4 co-treated with GATA6] affects the reaction [Nicotine results in increased expression of CHRNA7 mRNA]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine promotes the reaction [GATA6 protein binds to SP1 protein]
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GATA6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GATA6 mRNA]
CTD PMID:20230807 PMID:24089524 NCBI chr18:2,460,909...2,492,322
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Gatad2b GATA zinc finger domain containing 2B increases expression ISO Nicotine results in increased expression of GATAD2B mRNA CTD PMID:33640489 NCBI chr 2:178,046,192...178,127,633
Ensembl chr 2:175,749,433...175,825,542
JBrowse link
G Gch1 GTP cyclohydrolase 1 increases expression ISO Nicotine results in increased expression of GCH1 mRNA CTD PMID:16949557 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GCLC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GCLC mRNA] CTD PMID:20230807 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gcm1 glial cells missing transcription factor 1 decreases expression EXP Nicotine results in decreased expression of GCM1 mRNA; Nicotine results in decreased expression of GCM1 protein CTD PMID:24368670 NCBI chr 8:87,805,993...87,819,229
Ensembl chr 8:78,925,687...78,938,924
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 increases expression
decreases expression
ISO Nicotine results in increased expression of GCNT2 mRNA
Nicotine results in decreased expression of GCNT2 mRNA
CTD PMID:17997037 PMID:21955143 NCBI chr17:24,002,592...24,107,339
Ensembl chr17:23,796,859...23,901,611
JBrowse link
G Gdf1 growth differentiation factor 1 increases expression ISO Nicotine results in increased expression of GDF1 mRNA CTD PMID:18247414 NCBI chr16:19,131,271...19,146,480
Ensembl chr16:19,097,314...19,112,519
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle increases expression ISO Nicotine results in increased expression of GEM mRNA CTD PMID:17456735 NCBI chr 5:30,011,641...30,022,554
Ensembl chr 5:25,214,309...25,225,222
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression
ISO Nicotine results in decreased expression of GFAP mRNA
Nicotine results in increased expression of GFAP mRNA
CTD PMID:17997037 PMID:21955143 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Ggct gamma-glutamyl cyclotransferase increases splicing ISO Nicotine results in increased splicing of GGCT mRNA alternative form CTD PMID:23825647 NCBI chr 4:85,453,387...85,459,597
Ensembl chr 4:84,123,118...84,129,277
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions
increases activity
EXP Sodium Acetate inhibits the reaction [Nicotine results in increased activity of GGT1 protein] CTD PMID:31857090 NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Ghitm growth hormone inducible transmembrane protein multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GHITM mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GHITM mRNA] CTD PMID:20230807 NCBI chr16:12,907,062...12,918,149
Ensembl chr16:12,885,553...12,897,879
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression ISO Nicotine results in increased expression of GJA1 mRNA; Nicotine results in increased expression of GJA1 protein CTD PMID:36720419 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gja4 gap junction protein, alpha 4 increases expression EXP Nicotine results in increased expression of GJA4 mRNA CTD PMID:28087314 NCBI chr 5:144,917,791...144,920,324
Ensembl chr 5:139,633,287...139,635,925
JBrowse link
G Gjc2 gap junction protein, gamma 2 increases expression ISO Nicotine results in increased expression of GJC2 mRNA CTD PMID:21955143 NCBI chr10:44,462,203...44,470,924
Ensembl chr10:43,962,642...43,970,467
JBrowse link
G Glipr1 GLI pathogenesis-related 1 increases expression ISO Nicotine results in increased expression of GLIPR1 mRNA CTD PMID:16949557 NCBI chr 7:49,373,579...49,399,190
Ensembl chr 7:47,487,345...47,498,429
JBrowse link
G Gm2a ganglioside GM2 activator increases expression
increases splicing
ISO Nicotine results in increased expression of GM2A mRNA
Nicotine results in increased splicing of GM2A mRNA alternative form
CTD PMID:23825647 NCBI chr10:39,719,919...39,732,452
Ensembl chr10:39,219,243...39,231,757
JBrowse link
G Gmfb glia maturation factor, beta multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GMFB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GMFB mRNA] CTD PMID:20230807 NCBI chr15:22,549,705...22,560,125
Ensembl chr15:20,067,263...20,080,331
JBrowse link
G Gnai2 G protein subunit alpha i2 increases splicing
multiple interactions
ISO Nicotine results in increased splicing of GNAI2 mRNA alternative form
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GNAI2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GNAI2 mRNA]
CTD PMID:20230807 PMID:23825647 NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Gng10 G protein subunit gamma 10 increases expression ISO Nicotine results in increased expression of GNG10 mRNA CTD PMID:16949557 NCBI chr 5:78,651,167...78,658,060
Ensembl chr 5:73,856,164...73,863,012
Ensembl chr 5:73,856,164...73,863,012
JBrowse link
G Gng11 G protein subunit gamma 11 decreases expression ISO Nicotine results in decreased expression of GNG11 mRNA CTD PMID:21955143 NCBI chr 4:32,977,681...32,983,121
Ensembl chr 4:32,023,003...32,028,442
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor decreases expression EXP Nicotine results in decreased expression of GNRHR mRNA CTD PMID:28986172 NCBI chr14:22,211,666...22,229,654
Ensembl chr14:21,856,871...21,874,861
JBrowse link
G Golga4 golgin A4 multiple interactions
increases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA] CTD PMID:16949557 NCBI chr 8:127,085,830...127,163,227 JBrowse link
G Golt1b golgi transport 1B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GOLT1B mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GOLT1B mRNA] CTD PMID:20230807 NCBI chr 4:177,064,071...177,077,165
Ensembl chr 4:175,333,092...175,346,153
JBrowse link
G Gosr2 golgi SNAP receptor complex member 2 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of GOSR2 mRNA CTD PMID:28065790 NCBI chr10:89,085,323...89,105,665
Ensembl chr10:88,586,299...88,605,625
JBrowse link
G Gpatch2 G patch domain containing 2 increases splicing ISO Nicotine results in increased splicing of GPATCH2 mRNA alternative form CTD PMID:23825647 NCBI chr13:101,316,413...101,457,109
Ensembl chr13:98,784,969...98,925,661
JBrowse link
G Gpnmb glycoprotein nmb increases expression ISO Nicotine results in increased expression of GPNMB mRNA CTD PMID:23825647 NCBI chr 4:79,341,128...79,362,366
Ensembl chr 4:78,010,197...78,049,367
JBrowse link
G Gpr50 G protein-coupled receptor 50 increases expression
increases splicing
ISO Nicotine results in increased expression of GPR50 mRNA
Nicotine results in increased splicing of GPR50 mRNA alternative form
CTD PMID:23825647 NCBI chr  X:154,413,592...154,419,236
Ensembl chr  X:149,368,900...149,373,486
JBrowse link
G Gpr6 G protein-coupled receptor 6 increases expression ISO Nicotine results in increased expression of GPR6 mRNA CTD PMID:21955143 NCBI chr20:46,072,480...46,075,251
Ensembl chr20:44,489,853...44,492,624
JBrowse link
G Gpr83 G protein-coupled receptor 83 increases expression EXP Nicotine results in increased expression of GPR83 mRNA CTD PMID:27782041 NCBI chr 8:19,974,995...19,985,483
Ensembl chr 8:11,693,540...11,704,028
JBrowse link
G Gpr88 G-protein coupled receptor 88 increases expression ISO Nicotine results in increased expression of GPR88 mRNA CTD PMID:21955143 NCBI chr 2:206,876,373...206,885,034
Ensembl chr 2:204,191,427...204,199,733
JBrowse link
G Gprasp1 G protein-coupled receptor associated sorting protein 1 increases expression ISO Nicotine results in increased expression of GPRASP1 mRNA CTD PMID:17456735 NCBI chr  X:103,556,493...103,564,275
Ensembl chr  X:98,709,841...98,772,851
JBrowse link
G Gprc5b G protein-coupled receptor, class C, group 5, member B increases expression ISO Nicotine results in increased expression of GPRC5B mRNA CTD PMID:21955143 NCBI chr 1:182,748,247...182,772,711
Ensembl chr 1:173,316,907...173,340,932
JBrowse link
G Gprc5c G protein-coupled receptor, class C, group 5, member C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPRC5C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPRC5C mRNA] CTD PMID:20230807 NCBI chr10:100,385,682...100,407,953
Ensembl chr10:99,887,077...99,908,926
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression
ISO
EXP
Nicotine inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]
dexpanthenol inhibits the reaction [Nicotine results in increased expression of GPT protein]
CTD PMID:35411647 PMID:38229321 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
increases expression
ISO
EXP
Nicotine results in decreased expression of GPX1 mRNA
Nicotine results in increased expression of GPX1 protein
CTD PMID:16949557 PMID:18343235 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA] CTD PMID:20230807 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Gramd1b GRAM domain containing 1B increases expression ISO Nicotine results in increased expression of GRAMD1B mRNA CTD PMID:23825647 NCBI chr 8:49,551,642...49,790,965
Ensembl chr 8:40,659,182...40,893,925
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP Nicotine inhibits the reaction [Ethanol increases phosphorylation of Gria1 protein in the prefrontal cortex, central amygdaloid nucleus] RGD PMID:27796078 RGD:405649737 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Grid1 glutamate ionotropic receptor delta type subunit 1 decreases methylation EXP Nicotine results in decreased methylation of GRID1 gene CTD PMID:32994467 NCBI chr16:10,145,018...10,894,184
Ensembl chr16:10,138,925...10,885,808
JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GRID2 mRNA; [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GRID2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRID2 mRNA] CTD PMID:20230807 NCBI chr 4:93,745,165...95,222,354
Ensembl chr 4:92,415,230...93,889,355
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 increases expression ISO Nicotine results in increased expression of GRIK2 mRNA CTD PMID:17997037 NCBI chr20:53,717,564...54,415,283
Ensembl chr20:52,133,851...52,838,375
JBrowse link
G Grm1 glutamate metabotropic receptor 1 decreases expression EXP Nicotine results in decreased expression of GRM1 mRNA CTD PMID:28339662 NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Grm2 glutamate metabotropic receptor 2 affects expression EXP Nicotine affects the expression of GRM2 mRNA CTD PMID:28339662 NCBI chr 8:116,158,810...116,171,857
Ensembl chr 8:107,280,099...107,293,146
JBrowse link
G Grm5 glutamate metabotropic receptor 5 increases expression ISO Nicotine results in increased expression of GRM5 mRNA CTD PMID:21955143 NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:141,312,368...141,882,274
JBrowse link
G Gsdma gasdermin A increases expression ISO Nicotine results in increased expression of GSDMA mRNA CTD PMID:23825647 NCBI chr10:84,110,590...84,135,804
Ensembl chr10:83,627,051...83,639,543
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions
increases expression
ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3A protein
Nicotine results in increased expression of and results in decreased phosphorylation of GSK3A protein
Nicotine results in increased expression of GSK3A mRNA
CTD PMID:12511591 PMID:31945395 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases expression
increases expression
ISO [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in increased phosphorylation of GSK3B protein
Nicotine results in decreased expression of GSK3B mRNA; Nicotine results in decreased expression of GSK3B protein
Nicotine results in increased expression of GSK3B mRNA
Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of GSK3B mRNA]; Carbon Tetrachloride inhibits the reaction [Nicotine results in decreased expression of GSK3B protein]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSK3B mRNA]; Nicotine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSK3B protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in decreased expression of GSK3B mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in decreased expression of GSK3B protein]; Nicotine results in increased expression of and results in decreased phosphorylation of GSK3B protein
CTD PMID:12511591 PMID:31945395 PMID:33640489 PMID:35411647 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP
ISO
Nicotine results in decreased activity of GSR protein CTD PMID:19778253 PMID:20498001 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 decreases expression
increases expression
increases activity
EXP Nicotine results in decreased expression of GSTA4 mRNA
Nicotine results in increased expression of GSTA4 mRNA
Nicotine results in increased activity of GSTA4 protein
CTD PMID:9774145 NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO Nicotine results in decreased expression of GSTK1 mRNA CTD PMID:17997037 NCBI chr 4:72,085,532...72,089,934
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression ISO Nicotine results in decreased expression of GSTM2 mRNA CTD PMID:33640489 NCBI chr 2:198,312,179...198,316,962
Ensembl chr 2:195,544,426...195,628,961
JBrowse link
G Guca1a guanylate cyclase activator 1A decreases expression ISO Nicotine results in decreased expression of GUCA1A mRNA CTD PMID:16949557 NCBI chr 9:21,080,782...21,096,221
Ensembl chr 9:13,588,525...13,598,565
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] CTD PMID:23907605 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239
JBrowse link
G H2az2 H2A.Z variant histone 2 decreases expression ISO Nicotine results in decreased expression of H2AZ2 mRNA CTD PMID:17456735 NCBI chr14:85,507,228...85,526,166
Ensembl chr14:81,293,299...81,312,144
Ensembl chr 4:81,293,299...81,312,144
Ensembl chr16:81,293,299...81,312,144
JBrowse link
G H3c1 H3 clustered histone 1 increases expression ISO Nicotine results in increased expression of H3C1 protein CTD PMID:35929799 NCBI chr17:41,796,236...41,796,759
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
JBrowse link
G Hand1 heart and neural crest derivatives expressed 1 decreases expression EXP
ISO
Nicotine results in decreased expression of HAND1 mRNA; Nicotine results in decreased expression of HAND1 protein CTD PMID:24368670 PMID:31507073 NCBI chr10:42,507,117...42,509,684
Ensembl chr10:42,006,651...42,009,213
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO Nicotine results in increased expression of HAVCR1 protein CTD PMID:21511693 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HBA-A1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HBA-A1 mRNA] CTD PMID:20230807 NCBI chr10:15,841,724...15,842,580
Ensembl chr10:15,307,815...15,338,392
JBrowse link
G Hdac1 histone deacetylase 1 increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of HDAC1 mRNA
Nicotine results in increased expression of HDAC1 mRNA; Nicotine results in increased expression of HDAC1 protein
SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 protein]
CTD PMID:24709674 PMID:34245815 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hdac2 histone deacetylase 2 increases expression
multiple interactions
decreases expression
EXP
ISO
Nicotine results in increased expression of HDAC2 mRNA; Nicotine results in increased expression of HDAC2 protein
SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 protein]
Nicotine results in decreased expression of HDAC2 protein
CTD PMID:24709674 PMID:31507073 PMID:31846720 PMID:34245815 NCBI chr20:42,101,815...42,126,486
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hdac4 histone deacetylase 4 multiple interactions
increases expression
ISO
EXP
Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein]
Nicotine results in increased expression of HDAC4 mRNA; Nicotine results in increased expression of HDAC4 protein
CTD PMID:31846720 NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:92,507,611...92,750,164
JBrowse link
G Hdac7 histone deacetylase 7 increases expression ISO Nicotine results in increased expression of HDAC7 mRNA CTD PMID:24709674 NCBI chr 7:130,803,013...130,841,181
Ensembl chr 7:128,923,920...128,962,072
JBrowse link
G Hddc2 HD domain containing 2 increases expression ISO Nicotine results in increased expression of HDDC2 mRNA CTD PMID:23825647 NCBI chr 1:28,100,669...28,133,008
Ensembl chr 1:26,294,030...26,313,935
JBrowse link
G Hells helicase, lymphoid specific multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA] CTD PMID:20230807 NCBI chr 1:246,113,580...246,159,230
Ensembl chr 1:236,701,758...236,746,844
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 increases expression ISO Nicotine results in increased expression of HEY1 mRNA CTD PMID:23825647 NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:93,095,498...93,100,312
JBrowse link
G Hgf hepatocyte growth factor affects expression
decreases expression
multiple interactions
EXP
ISO
Nicotine affects the expression of HGF mRNA
Nicotine results in decreased expression of HGF protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA
CTD PMID:32512034 PMID:33091441 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
decreases expression
multiple interactions
ISO Nicotine results in increased expression of HIF1A protein
Nicotine results in decreased expression of HIF1A mRNA
resveratrol inhibits the reaction [Nicotine results in decreased expression of HIF1A mRNA]
CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of HIF1A protein]
CTD PMID:22687363 PMID:24793809 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA; Mecamylamine inhibits the reaction [Nicotine results in increased expression of HINT1 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA]
Nicotine results in increased expression of HINT1 mRNA
CTD PMID:20230807 PMID:20514075 NCBI chr10:39,490,225...39,493,970
Ensembl chr 4:92,100,973...92,101,568
JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HIPK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HIPK1 mRNA] CTD PMID:20230807 NCBI chr 2:193,937,261...193,988,247
Ensembl chr 2:191,248,817...191,298,902
JBrowse link
G Hist1h2bc histone cluster 1, H2bc decreases expression ISO Nicotine results in decreased expression of H2BC4 mRNA CTD PMID:17456735 NCBI chr17:47,388,085...47,392,349
Ensembl chr17:42,694,723...42,696,642
JBrowse link
G Hist1h2bd histone cluster 1 H2B family member D increases expression ISO Nicotine results in increased expression of H2BC5 protein CTD PMID:35929799 NCBI chr17:47,488,627...47,489,008 JBrowse link
G Hltf helicase-like transcription factor decreases expression ISO Nicotine results in decreased expression of HLTF mRNA CTD PMID:18247414 NCBI chr 2:104,478,725...104,538,531
Ensembl chr 2:102,549,724...102,609,327
JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO Nicotine results in decreased expression of HMGA1 mRNA CTD PMID:16949557 NCBI chr20:5,612,902...5,620,596
Ensembl chr20:5,611,694...5,618,752
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression
affects expression
ISO
EXP
Nicotine results in increased expression of HMGCR mRNA
Nicotine affects the expression of HMGCR mRNA
CTD PMID:23416264 PMID:31972234 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Nicotine results in increased expression of HMGCS1 mRNA CTD PMID:21955143 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmox1 heme oxygenase 1 increases response to substance
affects expression
increases expression
multiple interactions
ISO
EXP
HMOX1 protein results in increased susceptibility to Nicotine
Nicotine affects the expression of HMOX1 mRNA
Nicotine results in increased expression of HMOX1 mRNA; Nicotine results in increased expression of HMOX1 protein
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 protein; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]; HMOX1 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HMOX1 protein]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA]
CTD PMID:22954530 PMID:23933227 PMID:23942037 PMID:24095726 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 increases expression ISO Nicotine results in increased expression of HNRNPA3 mRNA CTD PMID:17456735 NCBI chr 3:80,984,470...80,999,413
Ensembl chr 3:60,578,673...60,588,306
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HNRNPC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HNRNPC mRNA] CTD PMID:20230807 NCBI chr15:27,253,098...27,282,779
Ensembl chr15:24,779,450...24,809,183
JBrowse link
G Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 increases expression ISO Nicotine results in increased expression of HNRNPH2 mRNA CTD PMID:17456735 NCBI chr  X:102,074,175...102,080,115
Ensembl chr  X:97,780,785...97,787,041
JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L decreases expression ISO Nicotine results in decreased expression of HNRNPL mRNA CTD PMID:21955143 NCBI chr 1:93,226,373...93,239,084
Ensembl chr 1:84,100,879...84,111,553
JBrowse link
G Hnrnpll heterogeneous nuclear ribonucleoprotein L-like increases expression ISO Nicotine results in increased expression of HNRNPLL mRNA CTD PMID:17997037 NCBI chr 6:20,720,013...20,752,803
Ensembl chr 6:14,970,057...14,999,745
JBrowse link
G Hnrnpr heterogeneous nuclear ribonucleoprotein R increases expression ISO Nicotine results in increased expression of HNRNPR mRNA CTD PMID:17997037 NCBI chr 5:153,826,482...153,872,272
Ensembl chr 5:148,543,044...148,574,867
JBrowse link
G Homer1 homer scaffold protein 1 decreases expression ISO Nicotine results in decreased expression of HOMER1 mRNA CTD PMID:21955143 NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Hoxb9 homeo box B9 increases expression ISO Nicotine results in increased expression of HOXB9 mRNA CTD PMID:23825647 NCBI chr10:81,733,857...81,737,363
Ensembl chr10:81,237,312...81,240,818
JBrowse link
G Hp1bp3 heterochromatin protein 1, binding protein 3 increases expression ISO Nicotine results in increased expression of HP1BP3 mRNA CTD PMID:16949557 NCBI chr 5:155,719,109...155,746,329
Ensembl chr 5:150,433,740...150,463,000
JBrowse link
G Hpca hippocalcin increases expression ISO Nicotine results in increased expression of HPCA mRNA CTD PMID:21955143 NCBI chr 5:146,739,978...146,750,961
Ensembl chr 5:141,455,613...141,463,841
JBrowse link
G Hpcal4 hippocalcin-like 4 increases expression ISO Nicotine results in increased expression of HPCAL4 mRNA CTD PMID:23825647 NCBI chr 5:140,739,577...140,751,529
Ensembl chr 5:135,454,540...135,466,416
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases activity
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA]
Nicotine results in increased activity of HRAS protein
CTD PMID:15983034 PMID:20230807 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases expression
affects expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of HSD11B1 mRNA
Nicotine affects the expression of HSD11B1 mRNA
ursodoxicoltaurine inhibits the reaction [Nicotine results in increased expression of HSD11B1 mRNA]
CTD PMID:21955143 PMID:22265867 PMID:26803847 PMID:31972234 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression
affects expression
increases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of HSD11B2 mRNA; Nicotine results in decreased expression of HSD11B2 protein
Nicotine affects the expression of HSD11B2 mRNA
Nicotine results in increased expression of HSD11B2 mRNA; Nicotine results in increased expression of HSD11B2 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]
CTD PMID:22265867 PMID:29486207 PMID:31972234 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions
decreases expression
EXP
ISO
Taurine inhibits the reaction [Nicotine results in decreased expression of HSD17B1 protein]
Nicotine results in decreased expression of HSD17B1 mRNA
Nicotine results in decreased expression of HSD17B1 mRNA; Nicotine results in decreased expression of HSD17B1 protein
CTD PMID:20498001 PMID:30959089 NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,009,728...86,011,927
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases activity
decreases expression
EXP Nicotine results in decreased activity of HSD17B3 protein
Nicotine results in decreased expression of HSD17B3 mRNA; Nicotine results in decreased expression of HSD17B3 protein
CTD PMID:28986172 NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,027,229...1,058,554
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases splicing ISO Nicotine results in increased splicing of HSD17B7 mRNA alternative form CTD PMID:23825647 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:82,173,179...82,190,017
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases activity
decreases expression
EXP
ISO
Nicotine results in decreased activity of HSD3B1 protein
Nicotine results in decreased expression of HSD3B1 mRNA
Nicotine results in decreased expression of HSD3B1 mRNA; Nicotine results in decreased expression of HSD3B1 protein
CTD PMID:28986172 PMID:30959089 NCBI chr 2:188,858,574...188,864,694
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA]
Nicotine results in increased expression of HSP90AA1 mRNA; Nicotine results in increased expression of HSP90AA1 protein
CTD PMID:12115584 PMID:20230807 NCBI chr 6:135,523,604...135,529,687
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of HSPA5
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPA5 protein]
Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein]; Nicotine inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]
CTD PMID:18477628 PMID:24201001 PMID:28082123 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPE1 mRNA] CTD PMID:20230807 NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:56,589,789...56,593,089
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression
decreases expression
increases expression
ISO
EXP
Nicotine results in decreased expression of HTR1A protein
Nicotine decreases expression of Htr1a protein in the diencephalon
Nicotine results in increased expression of HTR1A protein
CTD
RGD
PMID:21324836 PMID:30247698 PMID:22921986 RGD:405850243 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions EXP Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein] CTD PMID:21316381 NCBI chr 8:91,395,405...91,414,815
Ensembl chr 8:82,517,360...82,534,549
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
increases expression
EXP [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of HTR2A protein; Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein]
Nicotine results in increased expression of HTR2A protein
CTD PMID:21316381 PMID:30247698 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Ibsp integrin-binding sialoprotein decreases expression EXP Nicotine results in decreased expression of IBSP mRNA CTD PMID:29981921 NCBI chr14:5,744,497...5,757,242
Ensembl chr14:5,439,829...5,452,693
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Nicotine results in increased expression of ICAM1 protein CTD PMID:12575837 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression ISO Nicotine results in decreased expression of ID1 mRNA CTD PMID:17997037 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Id2 inhibitor of DNA binding 2 increases splicing ISO Nicotine results in increased splicing of ID2 mRNA alternative form CTD PMID:23825647 NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression ISO Nicotine results in decreased expression of ID3 mRNA CTD PMID:17456735 NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression
increases expression
ISO Nicotine results in decreased expression of IDI1 mRNA
Nicotine results in increased expression of IDI1 mRNA
CTD PMID:16949557 PMID:17997037 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 increases expression
multiple interactions
ISO Nicotine results in increased expression of IFI27 mRNA
Nicotine inhibits the reaction [nickel chloride results in increased expression of IFI27 mRNA]
CTD PMID:23825647 PMID:37951547 NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:122,590,472...122,779,294
JBrowse link
G Ifi44 interferon-induced protein 44 increases expression ISO Nicotine results in increased expression of IFI44 mRNA CTD PMID:23825647 NCBI chr 2:243,286,050...243,303,869
Ensembl chr 2:240,626,066...240,643,844
JBrowse link
G Ifi44l interferon-induced protein 44-like increases expression ISO Nicotine results in increased expression of IFI44L mRNA CTD PMID:23825647 NCBI chr 2:243,328,629...243,366,404
Ensembl chr 2:240,668,713...240,706,359
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA] CTD PMID:31154625 NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:47,227,364...47,275,456
JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of IFITM1 mRNA CTD PMID:37951547 NCBI chr 1:205,496,757...205,498,796
Ensembl chr 1:196,067,963...196,069,169
JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 decreases expression ISO Nicotine results in decreased expression of IFNAR1 mRNA CTD PMID:18247414 NCBI chr11:44,211,769...44,238,206
Ensembl chr11:30,725,790...30,749,979
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein] CTD PMID:31154625 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma multiple interactions ISO Nicotine inhibits the reaction [IFNG protein results in increased expression of TNF mRNA] CTD PMID:24095726 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression
affects expression
increases expression
multiple interactions
EXP Nicotine results in decreased expression of IGF1 mRNA; Nicotine results in decreased expression of IGF1 protein
Nicotine affects the expression of IGF1 mRNA; Nicotine affects the expression of IGF1 protein
Nicotine results in increased expression of IGF1 mRNA
rosiglitazone inhibits the reaction [Nicotine results in decreased expression of IGF1 protein]
CTD PMID:20960268 PMID:22265867 PMID:29486207 PMID:31972234 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression
affects expression
increases expression
EXP Nicotine results in decreased expression of IGF1R mRNA; Nicotine results in decreased expression of IGF1R protein
Nicotine affects the expression of IGF1R mRNA
Nicotine results in increased expression of IGF1R mRNA
CTD PMID:20426880 PMID:20960268 PMID:22265867 PMID:31972234 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igf2 insulin-like growth factor 2 increases expression EXP Nicotine results in increased expression of IGF2 mRNA CTD PMID:29486207 NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Igf2bp2 insulin-like growth factor 2 mRNA binding protein 2 increases expression ISO Nicotine results in increased expression of IGF2BP2 mRNA CTD PMID:17997037 NCBI chr11:92,378,908...92,478,893
Ensembl chr11:78,874,414...78,974,377
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression ISO Nicotine results in increased expression of IGFBP2 mRNA CTD PMID:23825647 NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Igsf1 immunoglobulin superfamily, member 1 decreases expression ISO Nicotine results in decreased expression of IGSF1 mRNA CTD PMID:21955143 NCBI chr  X:133,947,717...133,963,154
Ensembl chr  X:129,069,896...129,085,139
JBrowse link
G Igsf3 immunoglobulin superfamily, member 3 increases expression ISO Nicotine results in increased expression of IGSF3 mRNA CTD PMID:23825647 NCBI chr 2:191,499,972...191,588,249
Ensembl chr 2:188,811,380...188,899,645
JBrowse link
G Ihh Indian hedgehog signaling molecule increases expression EXP Nicotine results in increased expression of IHH mRNA CTD PMID:27782041 NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:76,504,315...76,510,532
JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions
decreases secretion
ISO Nicotine results in decreased expression of IL10 mRNA
Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Nicotine results in decreased secretion of IL10 protein
[Eugenol co-treated with Acetylcysteine] inhibits the reaction [Nicotine results in decreased secretion of IL10 protein]; Acetylcysteine inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]; Eugenol inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]; Nicotine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]
CTD PMID:18247414 PMID:21237301 PMID:29673796 PMID:31926917 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein] CTD PMID:21237301 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Eugenol inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein] CTD PMID:21237301 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA] CTD PMID:23199342 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression
increases secretion
ISO
EXP
CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL18 protein]
Nicotine results in increased expression of IL18 protein
Nicotine results in increased expression of IL18 mRNA
CTD PMID:35131329 PMID:39098741 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Nicotine results in increased expression of and results in increased secretion of IL1A protein CTD PMID:18082304 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion
decreases expression
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA; CHRNA5 protein affects the reaction [Nicotine results in increased secretion of IL1B protein]; Nicotine inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]; Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Nicotine results in increased expression of and results in increased secretion of IL1B protein; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of IL1B protein]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]; U 0126 inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]
Nicotine results in increased expression of IL1B mRNA
Nicotine results in decreased expression of IL1B protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of IL1B mRNA; Nicotine inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
Nicotine results in increased expression of IL1B mRNA; Nicotine results in increased expression of IL1B protein
Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD PMID:15976189 PMID:16254210 PMID:18082304 PMID:19673871 PMID:20943775 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions
increases expression
EXP methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 mRNA]; methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 protein]
Nicotine results in increased expression of IL1R1 mRNA; Nicotine results in increased expression of IL1R1 protein
CTD PMID:27180639 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:42,504,735...42,579,937
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions EXP IL1RN protein inhibits the reaction [Nicotine results in increased activity of Capsaicin] CTD PMID:27180639 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Nicotine results in decreased susceptibility to IL2 protein CTD PMID:15231866 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il33 interleukin 33 increases secretion
multiple interactions
ISO Nicotine results in increased secretion of IL33 protein
[Nicotine co-treated with Quartz] results in increased expression of IL33 protein
Nicotine promotes the reaction [Lipopolysaccharides results in increased secretion of IL33 protein]
CTD PMID:29673796 PMID:36868510 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Il3ra interleukin 3 receptor subunit alpha decreases expression ISO Nicotine results in decreased expression of IL3RA mRNA CTD PMID:18247414 NCBI chr12:21,431,848...21,437,336
Ensembl chr12:16,318,081...16,323,484
JBrowse link
G Il4r interleukin 4 receptor multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of IL4RA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL4RA mRNA] CTD PMID:20230807 NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
decreases secretion
decreases expression
increases expression
ISO
EXP
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA; [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased secretion of IL6 protein; [Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased secretion of IL6 protein; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Nicotine results in increased expression of and results in increased secretion of IL6 protein; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA]
Nicotine results in increased secretion of IL6 protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of IL6 mRNA
Nicotine results in decreased secretion of IL6 protein
Nicotine results in decreased expression of IL6 mRNA; Nicotine results in decreased expression of IL6 protein
Nicotine results in increased expression of IL6 mRNA; Nicotine results in increased expression of IL6 protein
Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of IL6 mRNA]
CTD PMID:18082304 PMID:19673871 PMID:20943775 PMID:22093924 PMID:23199342 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il7 interleukin 7 multiple interactions ISO Nicotine results in increased expression of and results in increased secretion of IL7 protein CTD PMID:18082304 NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Il9 interleukin 9 decreases expression ISO Nicotine results in decreased expression of IL9 mRNA CTD PMID:18247414 NCBI chr17:8,117,028...8,120,151
Ensembl chr17:8,111,772...8,114,895
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 decreases expression ISO Nicotine results in decreased expression of INPPL1 mRNA CTD PMID:17456735 NCBI chr 1:165,595,047...165,609,503
Ensembl chr 1:156,183,059...156,197,500
JBrowse link
G Ins1 insulin 1 multiple interactions
increases expression
EXP
ISO
Sodium Acetate inhibits the reaction [Nicotine results in increased expression of INS1 protein]
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of CS mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of HGF mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PRDM16 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 protein; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA
CTD PMID:29155039 PMID:31857090 PMID:33091441 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Ins2 insulin 2 increases expression EXP Nicotine results in increased expression of INS2 mRNA CTD PMID:20426880 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Insig1 insulin induced gene 1 increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of INSIG1 mRNA
Nicotine results in decreased expression of INSIG1 mRNA
CTD PMID:23416264 PMID:26776438 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Insr insulin receptor decreases expression EXP Nicotine results in decreased expression of INSR mRNA; Nicotine results in decreased expression of INSR protein CTD PMID:20960268 PMID:22265867 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA] CTD PMID:20230807 NCBI chr  X:156,919,927...156,929,825
Ensembl chr  X:151,768,777...151,778,521
JBrowse link
G Irf6 interferon regulatory factor 6 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of IRF6 mRNA CTD PMID:37951547 NCBI chr13:107,200,876...107,220,083
Ensembl chr13:104,672,179...104,691,386
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions ISO IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IRF7 mRNA] CTD PMID:31154625 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Irf8 interferon regulatory factor 8 decreases expression
multiple interactions
ISO Nicotine results in decreased expression of IRF8 mRNA
[nickel chloride co-treated with Nicotine] results in increased expression of IRF8 mRNA
CTD PMID:17456735 PMID:37951547 NCBI chr19:65,699,284...65,721,066
Ensembl chr19:48,790,588...48,811,829
JBrowse link
G Irf9 interferon regulatory factor 9 increases expression ISO Nicotine results in increased expression of IRF9 mRNA CTD PMID:33640489 NCBI chr15:33,065,422...33,071,881
Ensembl chr15:29,095,789...29,101,236
JBrowse link
G Irs1 insulin receptor substrate 1 decreases expression EXP Nicotine results in decreased expression of IRS1 mRNA CTD PMID:22265867 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Irx3 iroquois homeobox 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA] CTD PMID:20230807 NCBI chr19:31,384,803...31,388,241
Ensembl chr19:15,211,878...15,215,317
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA] CTD PMID:31154625 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of ISG20 mRNA CTD PMID:37951547 NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Itga2b integrin subunit alpha 2b decreases expression ISO Nicotine results in decreased expression of ITGA2B mRNA; Nicotine results in decreased expression of ITGA2B protein CTD PMID:21385097 NCBI chr10:87,908,697...87,926,225
Ensembl chr10:87,408,536...87,426,168
JBrowse link
G Itgal integrin subunit alpha L decreases expression ISO Nicotine results in decreased expression of ITGAL mRNA CTD PMID:18247414 NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:181,918,183...181,955,732
JBrowse link
G Itgav integrin subunit alpha V increases expression ISO Nicotine results in increased expression of ITGAV mRNA CTD PMID:17997037 NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Nicotine results in decreased expression of ITGB1 protein CTD PMID:11338295 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Itgb3 integrin subunit beta 3 decreases expression ISO Nicotine results in decreased expression of ITGB3 mRNA; Nicotine results in decreased expression of ITGB3 protein CTD PMID:21385097 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Itgb5 integrin subunit beta 5 increases expression EXP Nicotine results in increased expression of ITGB5 mRNA CTD PMID:20426880 NCBI chr11:80,333,588...80,449,373
Ensembl chr11:66,829,285...66,944,472
JBrowse link
G Itm2b integral membrane protein 2B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ITM2B mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ITM2B mRNA] CTD PMID:20230807 NCBI chr15:54,955,549...54,978,455
Ensembl chr15:48,546,001...48,568,917
JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B increases expression EXP Nicotine results in increased expression of ITPKB mRNA CTD PMID:11478936 NCBI chr13:94,601,072...94,696,180
Ensembl chr13:92,069,216...92,162,004
JBrowse link
G Ivl involucrin decreases expression ISO Nicotine results in decreased expression of IVL protein CTD PMID:16011614 NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:178,147,061...178,149,100
JBrowse link
G Jagn1 jagunal homolog 1 decreases expression ISO Nicotine results in decreased expression of JAGN1 mRNA CTD PMID:17997037 NCBI chr 4:148,147,213...148,151,915
Ensembl chr 4:146,591,510...146,596,288
JBrowse link
G Jak2 Janus kinase 2 increases response to substance
increases phosphorylation
multiple interactions
decreases expression
ISO
EXP
JAK2 results in increased susceptibility to Nicotine
Nicotine results in increased phosphorylation of JAK2 protein
Bungarotoxins inhibits the reaction [Nicotine results in increased phosphorylation of JAK2 protein]
Nicotine results in decreased expression of JAK2 mRNA
CTD PMID:20943775 PMID:29155039 PMID:34153408 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of JMJD6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of JMJD6 mRNA] CTD PMID:20230807 NCBI chr10:102,539,935...102,545,986
Ensembl chr10:102,041,120...102,047,182
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
increases phosphorylation
multiple interactions
ISO
EXP
Nicotine results in increased expression of JUN protein
Nicotine results in increased phosphorylation of JUN protein
Nicotine promotes the reaction [MAPK8 protein results in increased phosphorylation of JUN protein]
[U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; Nicotine inhibits the reaction [Cisplatin results in increased expression of JUN mRNA]
CTD PMID:11592233 PMID:17003101 PMID:17021677 PMID:21511693 PMID:34890707 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression
decreases expression
ISO Nicotine results in increased expression of JUNB mRNA
Nicotine results in decreased expression of JUNB mRNA
CTD PMID:17456735 PMID:17997037 PMID:18805435 PMID:21955143 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Kat6b lysine acetyltransferase 6B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of KAT6B mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KAT6B mRNA] CTD PMID:20230807 NCBI chr15:2,688,535...2,861,443
Ensembl chr15:2,639,200...2,812,316
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 increases expression ISO Nicotine results in increased expression of KCNH2 mRNA CTD PMID:17997037 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 decreases expression EXP Nicotine results in decreased expression of KCNK1 mRNA CTD PMID:11478936 NCBI chr19:70,856,985...70,895,053
Ensembl chr19:53,959,657...53,997,724
JBrowse link
G Kdm7a lysine demethylase 7A increases expression ISO Nicotine results in increased expression of KDM7A mRNA CTD PMID:16949557 NCBI chr 4:68,866,263...68,992,979
Ensembl chr 4:67,904,307...67,966,998
JBrowse link
G Kdr kinase insert domain receptor increases expression
decreases expression
EXP Nicotine results in increased expression of KDR mRNA
Nicotine results in decreased expression of KDR protein
CTD PMID:32512034 PMID:33091441 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Kif21b kinesin family member 21B increases expression ISO Nicotine results in increased expression of KIF21B mRNA CTD PMID:23825647 NCBI chr13:50,127,842...50,177,822
Ensembl chr13:47,576,160...47,626,127
JBrowse link
G Kif3b kinesin family member 3B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of KIF3B mRNA; Nicotine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KIF3B mRNA] CTD PMID:20230807 NCBI chr 3:162,218,621...162,258,191
Ensembl chr 3:141,758,466...141,797,963
JBrowse link
G Klf10 KLF transcription factor 10 decreases expression
increases expression
ISO Nicotine results in decreased expression of KLF10 mRNA
Nicotine results in increased expression of KLF10 mRNA
CTD PMID:17456735 PMID:17997037 NCBI chr 7:71,352,612...71,358,680
Ensembl chr 7:69,465,619...69,473,994
JBrowse link
G Klf11 KLF transcription factor 11 decreases expression ISO Nicotine results in decreased expression of KLF11 mRNA CTD PMID:18247414 NCBI chr 6:47,014,312...47,026,152
Ensembl chr 6:41,285,842...41,297,550
JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA]
Nicotine results in increased expression of KLF4 mRNA
CTD PMID:17456735 PMID:20230807 NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Klk5 kallikrein related-peptidase 5 increases expression ISO Nicotine results in increased expression of KLK5 mRNA CTD PMID:23825647 NCBI chr 1:103,432,743...103,442,011
Ensembl chr 1:94,296,168...94,304,666
JBrowse link
G Kmt2c lysine methyltransferase 2C multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA] CTD PMID:12588870 NCBI chr 4:10,353,698...10,755,965
Ensembl chr 4:9,609,627...9,833,539
JBrowse link
G Kng1 kininogen 1 multiple interactions
decreases activity
EXP Capsaicin promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form]; Kainic Acid promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form] CTD PMID:7807204 NCBI chr11:91,317,354...91,340,148
Ensembl chr11:77,812,752...77,835,555
JBrowse link
G Krt15 keratin 15 increases expression ISO Nicotine results in increased expression of KRT15 mRNA CTD PMID:23825647 NCBI chr10:85,567,197...85,571,014
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Krt80 keratin 80 increases expression ISO Nicotine results in increased expression of KRT80 mRNA CTD PMID:23825647 NCBI chr 7:134,341,951...134,363,872
Ensembl chr 7:132,463,218...132,485,508
JBrowse link
G Krt85 keratin 85 increases expression ISO Nicotine results in increased expression of KRT85 mRNA CTD PMID:23825647 NCBI chr 7:134,508,913...134,515,786
Ensembl chr 7:132,630,058...132,637,049
JBrowse link
G Lamb1 laminin subunit beta 1 increases expression ISO Nicotine results in increased expression of LAMB1 mRNA CTD PMID:16949557 NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:47,835,525...47,902,585
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 decreases expression ISO Nicotine results in decreased expression of LAMP2 protein CTD PMID:33010382 NCBI chr  X:122,038,734...122,087,745
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Lce1b late cornified envelope 1B increases expression ISO Nicotine results in increased expression of LCE1B mRNA CTD PMID:23825647 NCBI chr 2:180,951,824...180,953,140
Ensembl chr 2:178,256,213...178,257,985
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO LCK protein promotes the reaction [Nicotine results in increased phosphorylation of and results in increased activity of FYN protein]; Nicotine results in increased phosphorylation of and results in increased activity of LCK protein CTD PMID:17709503 NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 affects response to substance ISO LCP1 gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr15:56,846,375...56,954,090
Ensembl chr15:50,488,149...50,544,680
JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Nicotine results in increased expression of LDLR mRNA CTD PMID:23416264 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Ldlrad3 low density lipoprotein receptor class A domain containing 3 increases splicing ISO Nicotine results in increased splicing of LDLRAD3 mRNA alternative form CTD PMID:23825647 NCBI chr 3:108,694,528...108,936,330
Ensembl chr 3:88,239,622...88,481,267
JBrowse link
G Lep leptin increases expression
decreases response to substance
EXP Nicotine results in increased expression of LEP protein
Nicotine results in decreased susceptibility to LEP protein
CTD PMID:23623838 PMID:29155039 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lepr leptin receptor increases expression
decreases expression
EXP Nicotine results in increased expression of LEPR mRNA
Nicotine results in decreased expression of LEPR mRNA
CTD PMID:22265867 PMID:29155039 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Lgals1 galectin 1 increases expression ISO Nicotine results in increased expression of LGALS1 mRNA CTD PMID:23825647 NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:110,481,392...110,488,345
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
increases secretion
EXP
ISO
Nicotine results in decreased expression of LHB mRNA; Nicotine results in decreased expression of LHB protein
Nicotine results in increased secretion of LHB protein
CTD PMID:12893845 PMID:20498001 PMID:28986172 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lig4 DNA ligase 4 increases expression ISO Nicotine results in increased expression of LIG4 mRNA CTD PMID:16949557 NCBI chr16:86,220,345...86,228,930
Ensembl chr16:79,518,312...79,527,040
JBrowse link
G Lin7c lin-7 homolog C, crumbs cell polarity complex component decreases expression ISO Nicotine results in decreased expression of LIN7C mRNA CTD PMID:21955143 NCBI chr 3:116,859,425...116,872,363
Ensembl chr 3:96,406,813...96,417,728
JBrowse link
G Lipe lipase E, hormone sensitive type decreases expression EXP Nicotine results in decreased expression of LIPE mRNA CTD PMID:29155039 NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:80,965,627...80,984,310
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor multiple interactions
increases expression
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA]; Mecamylamine promotes the reaction [Nicotine results in decreased expression of LITAF mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA]
Nicotine results in increased expression of LITAF mRNA
CTD PMID:12588870 PMID:21955143 NCBI chr10:5,163,258...5,199,930
Ensembl chr10:4,625,552...4,692,763
JBrowse link
G Lmo7 LIM domain 7 decreases expression ISO Nicotine results in decreased expression of LMO7 mRNA CTD PMID:21955143 NCBI chr15:84,981,689...85,184,554
Ensembl chr15:78,567,023...78,769,783
JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of LPAR4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of LPAR4 mRNA] CTD PMID:20230807 NCBI chr  X:76,106,319...76,119,807
Ensembl chr  X:72,033,486...72,046,977
JBrowse link
G Lpl lipoprotein lipase increases expression ISO Nicotine results in increased expression of LPL mRNA CTD PMID:21955143 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrrfip1 LRR binding FLII interacting protein 1 increases expression ISO Nicotine results in increased expression of LRRFIP1 mRNA CTD PMID:16949557 NCBI chr 9:99,039,590...99,167,805
Ensembl chr 9:91,643,197...91,720,250
JBrowse link
G Lrrtm4 leucine rich repeat transmembrane neuronal 4 increases methylation EXP Nicotine results in increased methylation of LRRTM4 gene CTD PMID:32994467 NCBI chr 4:114,103,783...114,894,696
Ensembl chr 4:112,545,917...113,335,865
JBrowse link
G Ltb lymphotoxin beta decreases expression ISO Nicotine results in decreased expression of LTB mRNA CTD PMID:18247414 NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,627,537...3,629,381
JBrowse link
G Ltf lactotransferrin decreases expression ISO Nicotine results in decreased expression of LTF mRNA CTD PMID:23825647 NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:110,999,948...111,022,795
JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of LTN1 mRNA CTD PMID:28065790 NCBI chr11:40,090,169...40,147,159
Ensembl chr11:26,603,903...26,660,886
JBrowse link
G Lyl1 LYL1, basic helix-loop-helix family member decreases expression ISO Nicotine results in decreased expression of LYL1 mRNA CTD PMID:17456735 NCBI chr19:40,356,967...40,359,834
Ensembl chr19:23,452,140...23,455,007
JBrowse link
G Lysmd3 LysM domain containing 3 affects response to substance ISO LYSMD3 gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr 2:13,669,465...13,675,622
Ensembl chr 2:11,933,768...11,942,961
JBrowse link
G Madd MAP-kinase activating death domain decreases expression ISO Nicotine results in decreased expression of MADD mRNA CTD PMID:18247414 NCBI chr 3:97,570,141...97,613,688
Ensembl chr 3:77,114,314...77,157,701
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAOA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA] CTD PMID:20230807 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases expression EXP Nicotine results in increased expression of MAP2K6 mRNA CTD PMID:20426880 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAP2K7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP2K7 mRNA] CTD PMID:20230807 NCBI chr12:7,389,032...7,398,377
Ensembl chr12:2,591,219...2,604,222
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity
increases phosphorylation
decreases expression
multiple interactions
increases expression
ISO
EXP
Nicotine results in increased activity of MAPK1 protein
Nicotine results in increased phosphorylation of MAPK1 protein
Nicotine results in decreased expression of MAPK1 protein
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAPK1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAPK1 mRNA]
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK1 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein
Nicotine results in increased expression of MAPK1 protein modified form
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK1 protein; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of MAPK1 protein; [Nicotine co-treated with Ethanol] results in increased phosphorylation of MAPK1 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Nicotine; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in decreased activity of MAPK1 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Nicotine inhibits the reaction [Cisplatin results in increased activity of MAPK1 protein]; Nicotine inhibits the reaction [Fluorouracil results in increased phosphorylation of MAPK1 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein]; Nicotine results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Propranolol inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]
CTD PMID:12421819 PMID:12460746 PMID:15983034 PMID:17003101 PMID:17459420 More... NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk11 mitogen-activated protein kinase 11 decreases expression ISO Nicotine results in decreased expression of MAPK11 mRNA CTD PMID:17135361 NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:120,218,478...120,225,395
JBrowse link
G Mapk13 mitogen activated protein kinase 13 decreases expression ISO Nicotine results in decreased expression of MAPK13 mRNA CTD PMID:17135361 NCBI chr20:6,836,979...6,847,197
Ensembl chr20:6,835,320...6,844,222
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases expression
increases expression
increases activity
decreases activity
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Camptothecin co-treated with Nicotine] results in increased phosphorylation of MAPK3 protein; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of MAPK3 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of FOS protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Nicotine; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine results in decreased activity of MAPK3 protein]; Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Nicotine inhibits the reaction [Cisplatin results in increased activity of MAPK3 protein]; Nicotine inhibits the reaction [Fluorouracil results in increased phosphorylation of MAPK3 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased activity of MAPK3 protein]; Nicotine results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Propranolol inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]
Nicotine results in decreased expression of MAPK3 protein
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK3 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Nicotine results in increased phosphorylation of and results in increased activity of MAPK3 protein
Nicotine results in decreased expression of MAPK3 mRNA; Nicotine results in decreased expression of MAPK3 protein
Nicotine results in increased expression of MAPK3 protein modified form
Nicotine results in increased activity of MAPK3 protein
CTD PMID:12421819 PMID:12460746 PMID:15983034 PMID:17003101 PMID:17135361 More... NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
increases expression
increases activity
ISO
EXP
Nicotine results in increased phosphorylation of MAPK8 protein
Nicotine promotes the reaction [MAPK8 protein results in increased phosphorylation of JUN protein]
Nicotine results in increased expression of MAPK8 mRNA
Nicotine results in increased activity of MAPK8 protein
Curcumin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]; Nicotine inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]
CTD PMID:11592233 PMID:17021677 PMID:20426880 PMID:20727180 PMID:21511693 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases expression EXP Nicotine results in decreased expression of MAPK9 mRNA CTD PMID:26776438 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mast2 microtubule associated serine/threonine kinase 2 increases expression ISO Nicotine results in increased expression of MAST2 mRNA CTD PMID:33640489 NCBI chr 5:135,013,006...135,152,195
Ensembl chr 5:129,775,676...129,915,606
JBrowse link
G Mbp myelin basic protein increases phosphorylation EXP Nicotine results in increased phosphorylation of MBP protein CTD PMID:15983034 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of MCL1 protein]; [Nicotine results in increased phosphorylation of MCL1 protein] which results in increased expression of and results in increased stability of MCL1 protein; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of MCL1 protein] CTD PMID:19903766 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mcmdc2 minichromosome maintenance domain containing 2 increases expression EXP Nicotine results in increased expression of MCMDC2 mRNA CTD PMID:27782041 NCBI chr 5:14,071,609...14,120,435
Ensembl chr 5:9,298,101...9,338,300
JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 decreases expression ISO Nicotine results in decreased expression of MCTP1 mRNA CTD PMID:21955143 NCBI chr 2:7,798,968...8,493,596
Ensembl chr 2:6,065,808...6,761,833
JBrowse link
G Mdh2 malate dehydrogenase 2 decreases activity
multiple interactions
EXP Nicotine results in decreased activity of MDH2 protein
Folic Acid inhibits the reaction [Nicotine results in decreased activity of MDH2 protein]
CTD PMID:29972271 NCBI chr12:26,530,886...26,543,841
Ensembl chr12:20,894,262...20,907,271
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; [Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein CTD PMID:30272249 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Me1 malic enzyme 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ME1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ME1 mRNA] CTD PMID:20230807 NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Med24 mediator complex subunit 24 increases expression ISO Nicotine results in increased expression of MED24 mRNA CTD PMID:23825647 NCBI chr10:84,160,866...84,198,607
Ensembl chr10:83,664,609...83,690,123
JBrowse link
G Med28 mediator complex subunit 28 increases expression ISO Nicotine results in increased expression of MED28 mRNA CTD PMID:16949557 NCBI chr14:69,807,319...69,816,115
Ensembl chr14:65,594,647...65,603,583
JBrowse link
G Mef2c myocyte enhancer factor 2C affects expression EXP Nicotine affects the expression of MEF2C mRNA CTD PMID:20426880 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit increases expression ISO Nicotine results in increased expression of METTL3 mRNA CTD PMID:17456735 NCBI chr15:27,476,659...27,491,134
Ensembl chr15:25,003,172...25,014,041
JBrowse link
G Mgp matrix Gla protein multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in decreased expression of MGP protein CTD PMID:19910445 NCBI chr 4:171,497,472...171,500,888
Ensembl chr 4:169,766,279...169,769,667
JBrowse link
G Mir15b microRNA 15b decreases expression
increases methylation
ISO Nicotine results in decreased expression of MIR15B mRNA
Nicotine results in increased methylation of MIR15B gene
CTD PMID:33640489 NCBI chr 2:155,555,178...155,555,275
Ensembl chr 2:153,245,200...153,245,297
JBrowse link
G Mir98 microRNA 98 decreases expression
multiple interactions
ISO Nicotine results in decreased expression of MIR98 mRNA
MIR98 mRNA affects the reaction [Nicotine results in increased expression of NGF protein]; MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of EDN1 mRNA]; MIR98 mRNA inhibits the reaction [Nicotine results in increased expression of FN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in decreased expression of MIR98 mRNA]
CTD PMID:33082140 NCBI chr  X:24,460,648...24,460,755
Ensembl chr  X:20,981,235...20,981,342
JBrowse link
G Mirlet7b microRNA let-7b decreases expression ISO Nicotine results in decreased expression of MIRLET7B mRNA CTD PMID:33082140 NCBI chr 7:118,684,038...118,684,122
Ensembl chr 7:116,804,186...116,804,270
JBrowse link
G Mirlet7d microRNA let-7d decreases expression ISO Nicotine results in decreased expression of MIRLET7D mRNA CTD PMID:33082140 NCBI chr17:16,322,260...16,322,357
Ensembl chr17:16,115,893...16,115,990
JBrowse link
G Mirlet7g microRNA let-7g decreases expression ISO Nicotine results in decreased expression of MIRLET7G mRNA CTD PMID:33082140 NCBI chr 8:115,701,020...115,701,107
Ensembl chr 8:106,822,280...106,822,388
JBrowse link
G Mirlet7i microRNA let-7i decreases expression ISO Nicotine results in decreased expression of MIRLET7I mRNA CTD PMID:33082140 NCBI chr 7:60,527,877...60,527,961
Ensembl chr 7:58,642,480...58,642,571
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
increases expression
decreases expression
EXP
ISO
[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein; Hexamethonium inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein]; methyllycaconitine inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of MKI67 protein]
[Nicotine co-treated with Quartz] results in increased expression of MKI67 protein
Nicotine results in increased expression of MKI67 protein
Nicotine results in decreased expression of MKI67 protein
CTD PMID:29501575 PMID:30959089 PMID:31678612 PMID:36868510 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mlph melanophilin increases expression ISO Nicotine results in increased expression of MLPH mRNA CTD PMID:23825647 NCBI chr 9:98,955,036...98,990,566
Ensembl chr 9:91,507,591...91,542,983
JBrowse link
G Mme membrane metallo-endopeptidase increases expression ISO Nicotine results in increased expression of MME mRNA CTD PMID:23825647 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 mRNA]; lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]; Polymyxin B inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Polymyxin B inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein]
Nicotine results in increased expression of MMP1 mRNA; Nicotine results in increased expression of MMP1 protein
CTD PMID:17151781 PMID:18986645 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased expression of MMP13 mRNA; Nicotine results in increased expression of MMP13 protein
NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP13 mRNA]
Nicotine results in decreased expression of MMP13 mRNA
CTD PMID:17151781 PMID:34153408 PMID:39098741 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
increases expression
ISO
EXP
lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP2 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP2 mRNA]
Nicotine results in decreased expression of MMP2 mRNA
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA
Nicotine results in decreased expression of MMP2 protein
Nicotine results in increased expression of MMP2 mRNA; Nicotine results in increased expression of MMP2 protein
CTD PMID:14569062 PMID:17151781 PMID:18986645 PMID:20448088 PMID:23825647 More... NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
increases expression
ISO
EXP
lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP3 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP3 mRNA]; NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP3 mRNA]
Nicotine results in increased expression of MMP3 mRNA; Nicotine results in increased expression of MMP3 protein
CTD PMID:17151781 PMID:18986645 PMID:39098741 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions
increases expression
affects response to substance
ISO CREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of MMP7 mRNA]; MMP7 promoter SNP affects the reaction [Nicotine results in increased expression of MMP7 mRNA]
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA]
Nicotine results in increased expression of MMP7 mRNA; Nicotine results in increased expression of MMP7 protein
MMP7 promoter SNP affects the susceptibility to Nicotine
CTD PMID:20061081 PMID:20230807 PMID:25847246 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions
decreases expression
ISO Nicotine results in increased expression of MMP9 mRNA; Nicotine results in increased expression of MMP9 protein
MK-886 inhibits the reaction [Nicotine results in increased expression of MMP9 mRNA]
Nicotine results in decreased expression of MMP9 protein
CTD PMID:14569062 PMID:20061081 PMID:20448088 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase decreases activity
increases activity
multiple interactions
EXP Nicotine results in decreased activity of MPO protein
Nicotine results in increased activity of MPO protein
Acetylcysteine inhibits the reaction [Nicotine results in increased activity of MPO protein]; erdosteine inhibits the reaction [Nicotine results in increased activity of MPO protein]; Nicotine inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Vitamin E inhibits the reaction [Nicotine results in increased activity of MPO protein]
CTD PMID:15976189 PMID:17216608 PMID:23810507 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mrm3 mitochondrial rRNA methyltransferase 3 decreases expression ISO Nicotine results in decreased expression of MRM3 mRNA CTD PMID:17997037 NCBI chr10:61,594,155...61,623,659
Ensembl chr10:61,095,952...61,102,630
JBrowse link
G Mrpl10 mitochondrial ribosomal protein L10 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MRPL10 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL10 mRNA] CTD PMID:20230807 NCBI chr10:82,522,470...82,530,886
Ensembl chr10:82,026,031...82,034,443
JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL20 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL20 mRNA] CTD PMID:20230807 NCBI chr 5:171,690,664...171,695,728
Ensembl chr 5:166,408,962...166,413,492
JBrowse link
G Mrpl41 mitochondrial ribosomal protein L41 decreases expression ISO Nicotine results in decreased expression of MRPL41 mRNA CTD PMID:17997037 NCBI chr 3:28,178,837...28,179,755
Ensembl chr 3:7,779,143...7,782,818
JBrowse link
G Mrpl54 mitochondrial ribosomal protein L54 increases expression ISO Nicotine results in increased expression of MRPL54 mRNA CTD PMID:17456735 NCBI chr 7:9,103,525...9,106,045
Ensembl chr 7:8,452,716...8,455,321
JBrowse link
G Mrpl9 mitochondrial ribosomal protein L9 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MRPL9 mRNA] CTD PMID:20230807 NCBI chr 2:184,768,837...184,775,787
Ensembl chr 2:182,076,369...182,087,095
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO Nicotine results in increased expression of MSMO1 mRNA CTD PMID:23416264 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:24,980,697...24,998,016
JBrowse link
G Mst1 macrophage stimulating 1 decreases expression ISO Nicotine results in decreased expression of MST1 mRNA CTD PMID:18247414 NCBI chr 8:117,646,485...117,652,016
Ensembl chr 8:108,768,839...108,773,416
JBrowse link
G Msx1 msh homeobox 1 increases expression EXP Nicotine results in increased expression of MSX1 mRNA CTD PMID:20339300 NCBI chr14:77,185,802...77,189,735
Ensembl chr14:72,961,148...72,964,966
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression EXP Nicotine results in decreased expression of COX1 protein CTD PMID:28681937 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt1-ps3 metallothionein 1, pseudogene 3 increases expression ISO Nicotine results in increased expression of MT1E mRNA CTD PMID:23825647 NCBI chr17:79,695,812...79,696,200
Ensembl chr17:74,786,654...74,787,135
JBrowse link
G Mt2 metallothionein 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MT2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT2 mRNA] CTD PMID:20230807 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mt3 metallothionein 3 multiple interactions ISO [Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT3 protein] CTD PMID:23933227 NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,848,755...10,850,158
JBrowse link
G Mtch1 mitochondrial carrier 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MTCH1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTCH1 mRNA] CTD PMID:20230807 NCBI chr20:7,391,558...7,415,291
Ensembl chr20:7,389,949...7,413,426
JBrowse link
G Mtf2 metal response element binding transcription factor 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTF2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTF2 mRNA] CTD PMID:20230807 NCBI chr14:1,784,218...1,828,463
Ensembl chr14:1,640,746...1,683,524
JBrowse link
G Mtif2 mitochondrial translational initiation factor 2 increases expression ISO Nicotine results in increased expression of MTIF2 mRNA CTD PMID:16949557 NCBI chr14:107,465,719...107,486,663
Ensembl chr14:103,270,039...103,285,728
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression
multiple interactions
increases phosphorylation
EXP
ISO
Nicotine results in decreased expression of MTOR mRNA
Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]
dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]]; Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of MTOR protein]
Nicotine results in increased phosphorylation of MTOR protein
CTD PMID:26776438 PMID:30836163 PMID:31926917 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mx1 MX dynamin like GTPase 1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of MX1 mRNA CTD PMID:37951547 NCBI chr11:50,269,056...50,294,699
Ensembl chr11:36,799,660...36,823,507
JBrowse link
G Mybl2 MYB proto-oncogene like 2 decreases expression ISO Nicotine results in decreased expression of MYBL2 mRNA CTD PMID:16949557 NCBI chr 3:172,124,765...172,153,221
Ensembl chr 3:151,705,288...151,733,708
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases activity
increases expression
multiple interactions
decreases expression
ISO Nicotine results in increased activity of MYC protein
Nicotine results in increased expression of MYC protein
EIF4E protein affects the reaction [Nicotine results in increased expression of MYC protein]
Nicotine results in decreased expression of MYC mRNA
Nicotine results in decreased activity of and results in decreased expression of MYC protein
CTD PMID:17135361 PMID:17459420 PMID:30836163 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myh7 myosin heavy chain 7 increases expression EXP Nicotine results in increased expression of MYH7 protein CTD PMID:25280790 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Myl6 myosin light chain 6 decreases expression ISO Nicotine results in decreased expression of MYL6 mRNA CTD PMID:16949557 NCBI chr 7:1,495,301...1,498,512
Ensembl chr 7:910,774...933,791
JBrowse link
G Myo5b myosin Vb decreases expression ISO Nicotine results in decreased expression of MYO5B mRNA CTD PMID:17997037 NCBI chr18:70,313,717...70,613,918
Ensembl chr18:68,038,759...68,338,745
JBrowse link
G Myo9a myosin IXA increases expression ISO Nicotine results in increased expression of MYO9A mRNA CTD PMID:17997037 NCBI chr 8:69,044,853...69,248,094
Ensembl chr 8:60,149,234...60,350,514
JBrowse link
G Myof myoferlin increases splicing ISO Nicotine results in increased splicing of MYOF mRNA alternative form CTD PMID:23825647 NCBI chr 1:245,086,109...245,234,768
Ensembl chr 1:235,673,666...235,822,334
JBrowse link
G Mypn myopalladin decreases expression EXP Nicotine results in decreased expression of MYPN mRNA CTD PMID:27782041 NCBI chr20:25,435,554...25,521,149
Ensembl chr20:25,436,843...25,522,443
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions EXP Nicotine inhibits the reaction [Acetic Acid results in decreased expression of NAMPT protein] CTD PMID:23810507 NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Nanog Nanog homeobox increases expression
multiple interactions
ISO Nicotine results in increased expression of NANOG mRNA; Nicotine results in increased expression of NANOG protein
[Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of NANOG protein; SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of NANOG mRNA]
CTD PMID:23219715 PMID:30259641 PMID:31507073 NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Ncam1 neural cell adhesion molecule 1 multiple interactions ISO [Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NCAM1 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NCAM1 mRNA]
[nickel chloride co-treated with Nicotine] results in increased expression of NCAM1 mRNA
CTD PMID:23933227 PMID:37951547 NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases expression
ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Nicotine results in increased expression of NCF1 protein] CTD PMID:34171359 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 increases expression ISO Nicotine results in increased expression of NDUFA5 mRNA CTD PMID:16949557 NCBI chr 4:53,962,877...53,971,235
Ensembl chr 4:52,995,546...53,005,598
Ensembl chr 5:52,995,546...53,005,598
JBrowse link
G Ndufaf2 NADH:ubiquinone oxidoreductase complex assembly factor 2 decreases expression EXP Nicotine results in decreased expression of NDUFAF2 mRNA CTD PMID:27782041 NCBI chr 2:41,269,141...41,380,895
Ensembl chr 2:39,535,689...39,647,316
JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NDUFB5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFB5 mRNA] CTD PMID:20230807 NCBI chr 2:117,447,605...117,461,943
Ensembl chr 2:115,519,154...115,533,589
JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression EXP Nicotine results in decreased expression of NDUFB8 protein CTD PMID:28681937 NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:243,408,619...243,413,817
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO Nicotine results in increased expression of NEDD9 mRNA CTD PMID:17456735 NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,282,326...23,468,019
JBrowse link
G Nefm neurofilament medium chain increases expression ISO Nicotine results in increased expression of NEFM protein CTD PMID:20457658 NCBI chr15:46,535,857...46,541,161
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 multiple interactions ISO Nicotine promotes the reaction [NFATC2 protein results in decreased expression of CDK4 protein] CTD PMID:15231866 NCBI chr 3:177,615,189...177,747,493
Ensembl chr 3:157,198,872...157,328,325
JBrowse link
G Nfe2l1 NFE2 like bZIP transcription factor 1 increases splicing ISO Nicotine results in increased splicing of NFE2L1 mRNA alternative form CTD PMID:23825647 NCBI chr10:82,296,824...82,309,472
Ensembl chr10:81,800,366...81,832,318
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases activity
multiple interactions
decreases expression
increases expression
ISO
EXP
Nicotine results in increased activity of NFKB1 protein
Mecamylamine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]
Nicotine results in decreased expression of NFKB1 mRNA; Nicotine results in decreased expression of NFKB1 protein
Nicotine results in increased expression of NFKB1 mRNA
Vitamin K 3 inhibits the reaction [Nicotine results in increased activity of NFKB1 protein]
CTD PMID:16598845 PMID:17135361 PMID:27984197 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [Aerosols co-treated with Nicotine] results in increased expression of NFKB2 mRNA CTD PMID:33469865 NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:245,165,950...245,173,213
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases phosphorylation
increases degradation
increases expression
ISO
EXP
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; NSC 74859 inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
Nicotine results in increased phosphorylation of NFKBIA protein
Nicotine results in increased degradation of NFKBIA protein
Nicotine results in increased expression of NFKBIA mRNA
CTD PMID:17021677 PMID:17456735 PMID:20943775 PMID:34171359 PMID:34890707 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfkbie NFKB inhibitor epsilon decreases expression ISO Nicotine results in decreased expression of NFKBIE mRNA CTD PMID:18247414 NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:15,436,941...15,450,437
JBrowse link
G Nfyb nuclear transcription factor Y subunit beta decreases expression ISO Nicotine results in decreased expression of NFYB mRNA CTD PMID:18247414 NCBI chr 7:22,852,543...22,868,116
Ensembl chr 7:20,964,993...20,980,565
JBrowse link
G Ngb neuroglobin multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NGB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NGB mRNA] CTD PMID:20230807 NCBI chr 6:112,475,332...112,480,786
Ensembl chr 6:106,744,378...106,749,830
JBrowse link
G Ngf nerve growth factor increases expression
multiple interactions
ISO Nicotine results in increased expression of NGF mRNA
Nicotine results in increased expression of NGF mRNA; Nicotine results in increased expression of NGF protein
MIR98 mRNA affects the reaction [Nicotine results in increased expression of NGF protein]; NGF protein affects the reaction [Nicotine results in increased expression of COL1A1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of COL3A1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of EDN1 mRNA]; NGF protein affects the reaction [Nicotine results in increased expression of FN1 mRNA]; Rosiglitazone inhibits the reaction [Nicotine results in increased expression of NGF mRNA]
Nicotine results in increased expression of and results in increased secretion of NGF protein
CTD PMID:30076938 PMID:33082140 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO Nicotine results in increased expression of NGFR mRNA CTD PMID:30076938 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nherf2 NHERF family PDZ scaffold protein 2 decreases expression ISO Nicotine results in decreased expression of NHERF2 mRNA CTD PMID:18247414 NCBI chr10:14,167,005...14,177,519
Ensembl chr10:13,662,461...13,673,049
JBrowse link
G Niban1 niban apoptosis regulator 1 increases expression ISO Nicotine results in increased expression of NIBAN1 mRNA CTD PMID:23825647 NCBI chr13:66,224,219...66,377,728
Ensembl chr13:63,674,171...63,827,729
JBrowse link
G Nin ninein increases expression
multiple interactions
ISO Nicotine results in increased expression of NIN mRNA
alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of NIN mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA]
CTD PMID:16949557 NCBI chr 6:94,261,382...94,363,679
Ensembl chr 6:88,525,742...88,627,639
JBrowse link
G Nkain3 Sodium/potassium transporting ATPase interacting 3 decreases methylation EXP Nicotine results in decreased methylation of NKAIN3 gene CTD PMID:35026373 NCBI chr 5:38,410,576...39,106,910
Ensembl chr 5:33,623,713...34,309,381
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of NLRP3 mRNA; Nicotine results in increased expression of NLRP3 protein
Bungarotoxins inhibits the reaction [Nicotine results in increased expression of NLRP3 mRNA]; CHRNA5 protein affects the reaction [Nicotine results in increased expression of NLRP3 protein]; NLRP3 protein affects the reaction [Nicotine results in decreased expression of ACAN mRNA]; NLRP3 protein affects the reaction [Nicotine results in decreased expression of COL2A1 mRNA]; NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP13 mRNA]; NLRP3 protein affects the reaction [Nicotine results in increased expression of MMP3 mRNA]
CTD PMID:35131329 PMID:39098741 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 decreases expression ISO Nicotine results in decreased expression of NME3 mRNA CTD PMID:18247414 NCBI chr10:14,421,922...14,422,878
Ensembl chr10:13,917,403...13,918,359
JBrowse link
G Nme6 NME/NM23 nucleoside diphosphate kinase 6 decreases expression ISO Nicotine results in decreased expression of NME6 mRNA CTD PMID:17997037 NCBI chr 8:118,708,092...118,717,756
Ensembl chr 8:109,832,589...109,839,301
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased expression of NOS2 mRNA; Nicotine results in increased expression of NOS2 protein
Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]
Nicotine results in decreased expression of NOS2 mRNA; Nicotine results in decreased expression of NOS2 protein
Nicotine promotes the reaction [NOS2 protein results in increased abundance of Nitric Oxide]
[Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]; [Nicotine results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of NOS2 mRNA]; Eugenol inhibits the reaction [Nicotine results in increased expression of NOS2 mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NOS2 protein]
CTD PMID:16254210 PMID:16927020 PMID:17135361 PMID:18247414 PMID:19673871 More... NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO Nicotine results in increased expression of NOS3 mRNA CTD PMID:11166759 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Notch4 notch receptor 4 multiple interactions
decreases expression
EXP [Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein; [Saquinavir co-treated with Nicotine] results in decreased expression of NOTCH4 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]; Vitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]
Nicotine results in decreased expression of NOTCH4 protein
CTD PMID:20722969 NCBI chr20:4,164,969...4,189,072
Ensembl chr20:4,160,445...4,184,465
JBrowse link
G Nox4 NADPH oxidase 4 increases expression ISO Nicotine results in increased expression of NOX4 protein CTD PMID:20685820 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Npas3 neuronal PAS domain protein 3 decreases expression ISO Nicotine results in decreased expression of NPAS3 mRNA CTD PMID:23825647 NCBI chr 6:76,438,064...77,263,185
Ensembl chr 6:70,703,170...71,524,884
JBrowse link
G Npl N-acetylneuraminate pyruvate lyase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NPL mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NPL mRNA] CTD PMID:20230807 NCBI chr13:68,205,602...68,247,940
Ensembl chr13:65,655,118...65,697,372
JBrowse link
G Npy neuropeptide Y multiple interactions
decreases expression
increases expression
EXP Hexamethonium inhibits the reaction [Nicotine results in increased expression of NPY mRNA]
Nicotine results in decreased expression of NPY protein
Nicotine results in increased expression of NPY mRNA; Nicotine results in increased expression of NPY protein
CTD PMID:1907749 PMID:2233698 PMID:23623838 PMID:32512034 PMID:33091441 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions
decreases expression
ISO
EXP
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 protein]
Nicotine results in decreased expression of NR1H2 mRNA; Nicotine results in decreased expression of NR1H2 protein
CTD PMID:30036686 NCBI chr 1:104,178,483...104,183,863
Ensembl chr 1:95,041,967...95,047,377
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions
decreases expression
EXP
ISO
Nicotine promotes the reaction [NR1H3 protein binds to FASN promoter]; Nicotine results in increased expression of and results in increased activity of NR1H3 protein
Nicotine results in decreased expression of NR1H3 mRNA; Nicotine results in decreased expression of NR1H3 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein]
CTD PMID:24368177 PMID:30036686 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression
increases expression
EXP
ISO
Nicotine results in decreased expression of NR3C1 mRNA
Nicotine results in decreased expression of NR3C1 protein
Nicotine results in increased expression of NR3C1 mRNA; Nicotine results in increased expression of NR3C1 protein
CTD PMID:22265867 PMID:22975262 PMID:31783125 PMID:31972234 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 decreases expression EXP Nicotine results in decreased expression of NR3C2 mRNA CTD PMID:22975262 NCBI chr19:47,619,853...47,964,089
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression
decreases expression
ISO Nicotine results in increased expression of NR4A1 mRNA
Nicotine results in decreased expression of NR4A1 mRNA
CTD PMID:17456735 PMID:21955143 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of NR5A1 mRNA; Nicotine results in decreased expression of NR5A1 protein
trichostatin A inhibits the reaction [Nicotine results in decreased expression of NR5A1 mRNA]
CTD PMID:24709674 PMID:28986172 NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:22,465,502...22,486,328
JBrowse link
G Nrn1 neuritin 1 decreases expression ISO Nicotine results in decreased expression of NRN1 mRNA CTD PMID:21955143 NCBI chr17:28,335,426...28,344,354
Ensembl chr17:28,129,977...28,138,896
JBrowse link
G Nrxn3 neurexin 3 increases expression
increases methylation
ISO
EXP
Nicotine results in increased expression of NRXN3 mRNA
Nicotine results in increased methylation of NRXN3 gene
CTD PMID:21955143 PMID:32994467 NCBI chr 6:113,372,667...115,004,073
Ensembl chr 6:107,641,780...109,272,044
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NSF mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NSF mRNA] CTD PMID:20230807 NCBI chr10:89,227,937...89,357,383
Ensembl chr10:88,727,912...88,857,386
JBrowse link
G Nt5dc1 5'-nucleotidase domain containing 1 increases expression EXP Nicotine results in increased expression of NT5DC1 mRNA CTD PMID:27782041 NCBI chr20:39,660,707...39,763,647
Ensembl chr20:38,105,678...38,208,591
JBrowse link
G Ntng1 netrin G1 decreases expression ISO Nicotine results in decreased expression of NTNG1 mRNA CTD PMID:21955143 NCBI chr 2:200,151,979...200,515,031
Ensembl chr 2:197,463,945...197,826,997
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 increases expression ISO Nicotine results in increased expression of NTRK1 mRNA CTD PMID:30076938 NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of NTRK2 protein
[Nicotine co-treated with Quartz] results in increased phosphorylation of NTRK2 protein; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of NTRK2 protein]
methyllycaconitine inhibits the reaction [Nicotine results in increased expression of NTRK2 protein]
CTD PMID:16790237 PMID:36868510 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Ntsr1 neurotensin receptor 1 increases expression ISO Nicotine results in increased expression of NTSR1 mRNA CTD PMID:23825647 NCBI chr 3:187,983,778...188,033,934
Ensembl chr 3:167,606,215...167,656,377
JBrowse link
G Nudt4 nudix hydrolase 4 increases expression ISO Nicotine results in increased expression of NUDT4 mRNA CTD PMID:17997037 NCBI chr 7:32,074,978...32,091,491
Ensembl chr 7:30,188,100...30,204,615
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NUPR1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NUPR1 mRNA] CTD PMID:20230807 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:181,213,368...181,215,281
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A increases expression
multiple interactions
ISO Nicotine results in increased expression of OAS1 mRNA
Nicotine inhibits the reaction [Poly I-C results in increased expression of OAS1 mRNA]
CTD PMID:23825647 PMID:31154625 NCBI chr12:41,330,423...41,341,130
Ensembl chr12:35,669,801...35,680,517
JBrowse link
G Ogdh oxoglutarate dehydrogenase decreases activity
multiple interactions
EXP Nicotine results in decreased activity of OGDH protein
Folic Acid inhibits the reaction [Nicotine results in decreased activity of OGDH protein]
CTD PMID:29972271 NCBI chr14:85,363,949...85,431,405
Ensembl chr14:81,150,091...81,217,479
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO OGG1 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine] CTD PMID:29747151 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase increases expression ISO Nicotine results in increased expression of OGT mRNA CTD PMID:16949557 NCBI chr  X:70,811,317...70,856,123
Ensembl chr  X:66,771,349...66,816,146
JBrowse link
G Olfm4 olfactomedin 4 decreases expression ISO Nicotine results in decreased expression of OLFM4 mRNA CTD PMID:23825647 NCBI chr15:61,790,889...61,838,773
Ensembl chr15:55,407,148...55,429,681
JBrowse link
G Opalin oligodendrocytic myelin paranodal and inner loop protein decreases expression ISO Nicotine results in decreased expression of OPALIN mRNA CTD PMID:21955143 NCBI chr 1:249,840,539...249,858,423
Ensembl chr 1:239,891,142...239,908,788
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions ISO [naltrindole binds to and results in decreased activity of OPRD1 protein] which results in increased susceptibility to Nicotine CTD PMID:15778877 NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases expression ISO Nicotine results in decreased expression of OPRK1 mRNA CTD PMID:18247414 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 affects response to substance ISO OPRL1 protein affects the susceptibility to Nicotine CTD PMID:19371589 NCBI chr 3:189,209,495...189,225,406
Ensembl chr 3:168,834,003...168,839,920
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Nicotine CTD PMID:15778877 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Or4d6 olfactory receptor family 4 subfamily D member 6 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of OR4D6 mRNA CTD PMID:28065790 NCBI chr 1:218,463,801...218,464,745
Ensembl chr 1:209,037,992...209,045,985
JBrowse link
G Orc2 origin recognition complex, subunit 2 increases expression ISO Nicotine results in increased expression of ORC2 mRNA CTD PMID:16949557 NCBI chr 9:67,496,097...67,532,548
Ensembl chr 9:60,001,910...60,038,195
JBrowse link
G P3h3 prolyl 3-hydroxylase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of P3H3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of P3H3 mRNA] CTD PMID:20230807 NCBI chr 4:159,332,514...159,348,428
Ensembl chr 4:157,646,243...157,662,035
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta decreases expression EXP Nicotine results in decreased expression of P4HB protein CTD PMID:28681937 NCBI chr10:106,335,300...106,346,911
Ensembl chr10:105,836,982...105,848,500
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PAK2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA] CTD PMID:20230807 NCBI chr11:82,212,896...82,273,803
Ensembl chr11:68,707,969...68,768,816
JBrowse link
G Pank3 pantothenate kinase 3 increases expression ISO Nicotine results in increased expression of PANK3 mRNA CTD PMID:16949557 NCBI chr10:20,733,191...20,757,017
Ensembl chr10:20,229,129...20,252,955
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PARK7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PARK7 mRNA] CTD PMID:20230807 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression
ISO
EXP
Nicotine inhibits the reaction [Aflatoxin B1 results in increased expression of PARP1 protein modified form]; Nicotine inhibits the reaction [Camptothecin results in increased cleavage of PARP1 protein]; Nicotine inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; Nicotine inhibits the reaction [Fluorouracil results in increased cleavage of PARP1 protein]
Nicotine results in decreased expression of PARP1 protein
Folic Acid inhibits the reaction [Nicotine results in decreased expression of PARP1 protein]
CTD PMID:20457658 PMID:22743290 PMID:24095863 PMID:29972271 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 increases splicing ISO Nicotine results in increased splicing of PARP4 mRNA alternative form CTD PMID:23825647 NCBI chr15:34,806,203...34,908,492
Ensembl chr15:30,686,613...30,828,810
JBrowse link
G Patj PATJ, crumbs cell polarity complex component decreases expression ISO Nicotine results in decreased expression of PATJ mRNA CTD PMID:21955143 NCBI chr 5:118,177,557...118,480,301
Ensembl chr 5:113,062,118...113,364,807
JBrowse link
G Pax3 paired box 3 decreases expression EXP Nicotine results in decreased expression of PAX3 mRNA CTD PMID:20339300 NCBI chr 9:87,015,960...87,112,531
Ensembl chr 9:79,568,634...79,664,042
JBrowse link
G Pax6 paired box 6 decreases expression EXP Nicotine results in decreased expression of PAX6 mRNA CTD PMID:28555334 NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
G Pax8 paired box 8 increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of PAX8 mRNA
Nicotine results in decreased expression of PAX8 mRNA
CTD PMID:23825647 PMID:26776438 NCBI chr 3:27,584,000...27,641,094
Ensembl chr 3:7,185,723...7,242,363
JBrowse link
G Pcf11 PCF11 cleavage and polyadenylation factor subunit increases expression ISO Nicotine results in increased expression of PCF11 mRNA CTD PMID:17456735 NCBI chr 1:156,109,724...156,136,950
Ensembl chr 1:146,697,646...146,724,124
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
decreases expression
multiple interactions
ISO Nicotine results in increased expression of PCNA protein
Nicotine results in decreased expression of PCNA protein
royal jelly inhibits the reaction [Nicotine results in decreased expression of PCNA protein]
CTD PMID:18448488 PMID:20106947 PMID:30896085 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pde10a phosphodiesterase 10A decreases expression ISO Nicotine results in decreased expression of PDE10A mRNA CTD PMID:21955143 NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:51,770,132...52,216,563
JBrowse link
G Pdgfa platelet derived growth factor subunit A affects expression EXP Nicotine affects the expression of PDGFA mRNA CTD PMID:20426880 NCBI chr12:20,759,366...20,780,337
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions
increases expression
increases secretion
ISO
EXP
6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased expression of PDGFB mRNA]; 6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased secretion of PDGFB protein] CTD PMID:16149045 PMID:16254210 PMID:32512034 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of PDGFRB protein
Nicotine results in decreased phosphorylation of and results in decreased activity of PDGFRB protein
6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased expression of PDGFRB protein]
CTD PMID:16149045 PMID:20447445 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PDIA6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PDIA6 mRNA] CTD PMID:20230807 NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:40,062,926...40,080,613
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 increases expression ISO Nicotine results in increased expression of PDK1 mRNA CTD PMID:31945395 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 increases expression ISO Nicotine results in increased expression of PDK2 mRNA CTD PMID:31945395 NCBI chr10:80,469,388...80,483,988
Ensembl chr10:79,972,556...79,987,085
JBrowse link
G Pdlim2 PDZ and LIM domain 2 increases expression ISO Nicotine results in increased expression of PDLIM2 mRNA CTD PMID:21955143 NCBI chr15:51,647,195...51,659,904
Ensembl chr15:45,237,477...45,249,242
JBrowse link
G Penk proenkephalin affects response to substance ISO PENK protein affects the susceptibility to Nicotine CTD PMID:15689546 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Per1 period circadian regulator 1 increases expression ISO Nicotine results in increased expression of PER1 mRNA CTD PMID:17456735 NCBI chr10:54,299,002...54,313,804
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Pes1 pescadillo ribosomal biogenesis factor 1 decreases expression ISO Nicotine results in decreased expression of PES1 mRNA CTD PMID:17997037 NCBI chr14:83,074,346...83,090,726
Ensembl chr14:78,850,709...78,867,134
JBrowse link
G Pfdn1 prefoldin subunit 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PFDN1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PFDN1 mRNA] CTD PMID:20230807 NCBI chr18:28,288,210...28,341,198
Ensembl chr18:28,014,145...28,067,064
JBrowse link
G Pfn1 profilin 1 decreases expression EXP Nicotine results in decreased expression of PFN1 mRNA CTD PMID:11478936 NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,365,262...55,527,631
JBrowse link
G Pgf placental growth factor increases expression EXP Nicotine results in increased expression of PGF mRNA CTD PMID:32512034 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:104,816,104...104,826,685
JBrowse link
G Pgr progesterone receptor decreases expression ISO Nicotine results in decreased expression of PGR mRNA CTD PMID:27552315 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Phb1 prohibitin 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHB1 mRNA] CTD PMID:20230807 NCBI chr10:81,102,043...81,114,815
Ensembl chr10:80,605,251...80,618,042
JBrowse link
G Phf21a PHD finger protein 21A increases expression ISO Nicotine results in increased expression of PHF21A mRNA CTD PMID:16949557 NCBI chr 3:98,600,933...98,791,132
Ensembl chr 3:78,194,549...78,331,865
JBrowse link
G Phf3 PHD finger protein 3 increases expression ISO Nicotine results in increased expression of PHF3 mRNA CTD PMID:16949557 NCBI chr 9:40,559,929...40,632,096
Ensembl chr 9:33,063,857...33,135,994
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression ISO Nicotine results in increased expression of PHGDH mRNA CTD PMID:23825647 NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:185,906,966...185,935,944
JBrowse link
G Phldb1 pleckstrin homology-like domain, family B, member 1 increases expression ISO Nicotine results in increased expression of PHLDB1 mRNA CTD PMID:21955143 NCBI chr 8:53,900,338...53,948,325
Ensembl chr 8:45,003,538...45,051,522
JBrowse link
G Phldb3 pleckstrin homology-like domain, family B, member 3 decreases expression EXP Nicotine results in decreased expression of PHLDB3 mRNA CTD PMID:27782041 NCBI chr 1:89,328,991...89,347,446
Ensembl chr 1:80,201,578...80,219,534
JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 affects response to substance ISO PHLPP gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr13:22,823,132...23,045,619
Ensembl chr13:22,308,548...22,530,977
JBrowse link
G Phtf1 putative homeodomain transcription factor 1 multiple interactions
decreases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHTF1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHTF1 mRNA]
Nicotine results in decreased expression of PHTF1 mRNA
CTD PMID:17456735 PMID:20230807 NCBI chr 2:194,161,343...194,249,925
Ensembl chr 2:191,473,130...191,512,078
JBrowse link
G Pick1 protein interacting with PRKCA 1 decreases expression ISO Nicotine results in decreased expression of PICK1 mRNA CTD PMID:17997037 NCBI chr 7:112,676,890...112,697,275
Ensembl chr 7:110,797,117...110,816,848
JBrowse link
G Pidd1 p53-induced death domain protein 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIDD1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIDD1 mRNA] CTD PMID:20230807 NCBI chr 1:205,966,392...205,972,359
Ensembl chr 1:196,536,834...196,542,699
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A decreases expression ISO Nicotine results in decreased expression of PIGA mRNA CTD PMID:21955143 NCBI chr  X:33,672,832...33,687,747
Ensembl chr  X:30,042,343...30,055,804
JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIGC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIGC mRNA] CTD PMID:20230807 NCBI chr13:76,876,894...76,879,420
Ensembl chr13:74,296,854...74,346,211
JBrowse link
G Pigf phosphatidylinositol glycan anchor biosynthesis, class F increases expression ISO Nicotine results in increased expression of PIGF mRNA CTD PMID:16949557 NCBI chr 6:13,343,134...13,371,237
Ensembl chr 6:7,589,570...7,639,675
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha increases expression ISO Nicotine results in increased expression of PIK3CA mRNA CTD PMID:16949557 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PIN1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 mRNA] CTD PMID:20230807 NCBI chr 8:27,465,538...27,477,016
Ensembl chr 8:19,189,373...19,200,785
JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIP5K1C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIP5K1C mRNA] CTD PMID:20230807 NCBI chr 7:9,048,135...9,076,751
Ensembl chr 7:8,397,406...8,425,988
JBrowse link
G Pklr pyruvate kinase L/R multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of PKLR mRNA CTD PMID:28065790 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pkn2 protein kinase N2 increases expression ISO Nicotine results in increased expression of PKN2 mRNA CTD PMID:16949557 NCBI chr 2:234,454,001...234,559,369
Ensembl chr 2:231,793,584...231,898,953
JBrowse link
G Pla2g12a phospholipase A2, group XIIA decreases expression ISO Nicotine results in decreased expression of PLA2G12A mRNA CTD PMID:17997037 NCBI chr 2:221,110,722...221,126,966
Ensembl chr 2:218,436,513...218,452,740
JBrowse link
G Pla2g4a phospholipase A2 group 4A decreases expression EXP Nicotine results in decreased expression of PLA2G4A mRNA CTD PMID:26776438 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Plaa phospholipase A2, activating protein multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PLAA mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PLAA mRNA] CTD PMID:20230807 NCBI chr 5:114,544,327...114,576,023
Ensembl chr 5:109,428,265...109,460,282
JBrowse link
G Plat plasminogen activator, tissue type affects expression
increases expression
multiple interactions
ISO Nicotine affects the expression of PLAT mRNA
Nicotine results in increased expression of PLAT mRNA; Nicotine results in increased expression of PLAT protein
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of PLAT mRNA
CTD PMID:11166759 PMID:17151781 PMID:18986645 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
increases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of PLAU mRNA]
PLAU inhibits the reaction [Nicotine binds to CHRNA1 protein]
CTD PMID:19690163 PMID:20061081 PMID:23825647 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]; pyrazolanthrone inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]
Nicotine results in increased expression of PLAUR mRNA; Nicotine results in increased expression of PLAUR protein
CTD PMID:20061081 PMID:22261521 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression ISO Nicotine results in decreased expression of PLCD4 mRNA CTD PMID:21955143 NCBI chr 9:83,564,616...83,613,742
Ensembl chr 9:76,117,168...76,142,453
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP Nicotine results in increased phosphorylation of and results in increased activity of PLCG1 protein CTD PMID:15138183 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Pld1 phospholipase D1 decreases expression ISO Nicotine results in decreased expression of PLD1 mRNA CTD PMID:18247414 NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Pld2 phospholipase D2 increases expression ISO Nicotine results in increased expression of PLD2 mRNA CTD PMID:18247414 NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Plekhg1 pleckstrin homology and RhoGEF domain containing G1 affects response to substance
decreases expression
ISO PLEKHG1 gene SNP affects the susceptibility to Nicotine
Nicotine results in decreased expression of PLEKHG1 mRNA
CTD PMID:18438686 PMID:21955143 NCBI chr 1:42,612,023...42,841,727
Ensembl chr 1:40,311,221...40,434,063
JBrowse link
G Plin2 perilipin 2 decreases expression ISO Nicotine results in decreased expression of PLIN2 protein CTD PMID:31783125 NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO Nicotine results in increased expression of PLK2 mRNA CTD PMID:17456735 NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Pllp plasmolipin increases expression ISO Nicotine results in increased expression of PLLP mRNA CTD PMID:21955143 NCBI chr19:10,321,080...10,341,869
Ensembl chr19:10,315,104...10,335,892
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 decreases expression ISO Nicotine results in decreased expression of PLOD3 mRNA CTD PMID:17997037 NCBI chr12:25,313,070...25,323,631
Ensembl chr12:19,676,386...19,686,960
JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of PNMT mRNA
Nicotine results in increased expression of PNMT protein
imidacloprid promotes the reaction [Nicotine results in increased expression of PNMT protein]
CTD PMID:17498763 PMID:29246838 NCBI chr10:83,881,211...83,882,849
Ensembl chr10:83,384,923...83,386,556
JBrowse link
G Pnoc prepronociceptin affects response to substance ISO PNOC protein alternative form affects the susceptibility to Nicotine CTD PMID:19371589 NCBI chr15:43,800,240...43,827,841
Ensembl chr15:39,624,641...39,651,867
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 decreases expression
multiple interactions
EXP Nicotine results in decreased expression of PNPLA2 mRNA
[Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of PNPLA2 protein
CTD PMID:29155039 PMID:29617909 NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:196,552,723...196,557,805
JBrowse link
G Pnpla4 patatin like phospholipase domain containing 4 decreases expression ISO Nicotine results in decreased expression of PNPLA4 mRNA CTD PMID:16949557 NCBI chr  X:46,200,351...46,205,517
Ensembl chr  X:42,305,373...42,318,552
JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PNPLA8 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PNPLA8 mRNA] CTD PMID:20230807 NCBI chr 6:67,056,783...67,118,714
Ensembl chr 6:61,329,810...61,391,734
JBrowse link
G Pomc proopiomelanocortin affects response to substance
decreases expression
affects expression
multiple interactions
increases expression
ISO
EXP
POMC protein affects the susceptibility to Nicotine
Nicotine results in decreased expression of POMC protein
Nicotine affects the expression of POMC protein
POMC protein affects the reaction [Nicotine results in increased abundance of Dopamine]
Nicotine results in increased expression of POMC protein alternative form
CTD PMID:15689546 PMID:19376143 PMID:22975262 PMID:23623838 PMID:28555334 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Pon1 paraoxonase 1 decreases activity
multiple interactions
ISO Nicotine results in decreased activity of PON1 protein
PON1 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine]
CTD PMID:24478552 PMID:29747151 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pon2 paraoxonase 2 increases expression ISO Nicotine results in increased expression of PON2 mRNA CTD PMID:16949557 NCBI chr 4:34,356,270...34,391,684
Ensembl chr 4:33,389,714...33,425,248
JBrowse link
G Pou2af1 POU class 2 homeobox associating factor 1 decreases expression ISO Nicotine results in decreased expression of POU2AF1 mRNA CTD PMID:18247414 NCBI chr 8:60,418,173...60,445,176
Ensembl chr 8:51,474,015...51,548,819
JBrowse link
G Pou2f1 POU class 2 homeobox 1 increases expression ISO Nicotine results in increased expression of POU2F1 mRNA CTD PMID:18247414 NCBI chr13:80,653,602...80,796,279
Ensembl chr13:78,130,685...78,263,363
JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of POU5F1 mRNA; Nicotine results in increased expression of POU5F1 protein
Tubocurarine inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
CTD PMID:15612475 PMID:15749260 PMID:23219715 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Ppan peter pan homolog increases expression ISO Nicotine results in increased expression of PPAN mRNA CTD PMID:17456735 NCBI chr 8:27,700,147...27,704,127
Ensembl chr 8:19,423,961...19,427,938
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Nicotine results in decreased expression of PPARA mRNA CTD PMID:29155039 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases expression
ISO Nicotine results in increased expression of PPARG mRNA
Nicotine results in decreased expression of PPARG protein
CTD PMID:31622651 PMID:33082140 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of PPARGC1A mRNA; Nicotine results in decreased expression of PPARGC1A protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A protein
CTD PMID:29155039 PMID:33091441 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PPM1B mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PPM1B mRNA] CTD PMID:20230807 NCBI chr 6:15,399,559...15,460,301
Ensembl chr 6:9,655,765...9,707,974
JBrowse link
G Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha increases expression ISO Nicotine results in increased expression of PPP2R3A mRNA CTD PMID:16949557 NCBI chr 8:110,582,479...110,720,516
Ensembl chr 8:101,704,778...101,841,502
JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPP2R3C mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PPP2R3C mRNA] CTD PMID:20230807 NCBI chr 6:78,382,849...78,406,037
Ensembl chr 6:72,647,025...72,672,491
JBrowse link
G Ppp2r5d protein phosphatase 2, regulatory subunit B', delta decreases expression ISO Nicotine results in decreased expression of PPP2R5D mRNA CTD PMID:17997037 NCBI chr 9:21,767,963...21,797,997
Ensembl chr 9:14,268,745...14,300,400
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha decreases expression ISO Nicotine results in decreased expression of PPP3R1 mRNA CTD PMID:21955143 NCBI chr14:95,758,333...95,808,015
Ensembl chr14:91,604,121...91,606,907
JBrowse link
G Prdm16 PR/SET domain 16 multiple interactions
decreases expression
ISO
EXP
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PRDM16 mRNA
Nicotine results in decreased expression of PRDM16 mRNA
CTD PMID:33091441 NCBI chr 5:170,162,275...170,486,371
Ensembl chr 5:164,880,587...165,203,601
JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PRDX3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PRDX3 mRNA] CTD PMID:20230807 NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Prg4 proteoglycan 4 decreases expression ISO Nicotine results in decreased expression of PRG4 mRNA CTD PMID:33640489 NCBI chr13:65,037,363...65,054,764
Ensembl chr13:62,487,257...62,504,119
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 increases expression EXP Nicotine results in increased expression of PRKAA2 mRNA CTD PMID:22265867 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PRKAB1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRKAB1 mRNA] CTD PMID:20230807 NCBI chr12:46,248,971...46,259,487
Ensembl chr12:40,588,211...40,598,661
JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta increases expression ISO Nicotine results in increased expression of PRKAR2B mRNA CTD PMID:18247414 NCBI chr 6:54,291,143...54,381,639
Ensembl chr 6:48,563,662...48,653,933
JBrowse link
G Prkca protein kinase C, alpha increases activity
increases expression
ISO
EXP
Nicotine results in increased activity of PRKCA protein
Nicotine results in increased expression of PRKCA mRNA
CTD PMID:12421819 PMID:20426880 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcb protein kinase C, beta affects localization ISO Nicotine affects the localization of PRKCB protein CTD PMID:17003101 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkcd protein kinase C, delta decreases expression ISO Nicotine results in decreased expression of PRKCD mRNA CTD PMID:21955143 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkce protein kinase C, epsilon increases expression EXP Nicotine results in increased expression of PRKCE mRNA CTD PMID:20426880 NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Prkcsh PRKCSH beta subunit of glucosidase II decreases expression ISO Nicotine results in decreased expression of PRKCSH mRNA CTD PMID:16949557 NCBI chr 8:28,810,836...28,822,503
Ensembl chr 8:20,534,880...20,546,492
JBrowse link
G Prkcz protein kinase C, zeta multiple interactions
increases activity
ISO PRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein]
Nicotine results in increased activity of PRKCZ protein
CTD PMID:17525161 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases expression ISO Nicotine results in decreased expression of PRKN mRNA CTD PMID:16949557 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Prl prolactin increases secretion ISO Nicotine results in increased secretion of PRL protein CTD PMID:12893845 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prok1 prokineticin 1 decreases expression EXP Nicotine results in decreased expression of PROK1 protein CTD PMID:24368670 NCBI chr 2:197,538,747...197,547,550
Ensembl chr 2:194,853,991...194,859,250
JBrowse link
G Prom2 prominin 2 increases expression ISO Nicotine results in increased expression of PROM2 mRNA CTD PMID:23825647 NCBI chr 3:135,200,944...135,215,130
Ensembl chr 3:114,747,654...114,761,787
JBrowse link
G Prox1 prospero homeobox 1 increases expression ISO Nicotine results in increased expression of PROX1 mRNA CTD PMID:23825647 NCBI chr13:104,196,615...104,251,007
Ensembl chr13:101,669,184...101,711,183
JBrowse link
G Prpf38b pre-mRNA processing factor 38B increases expression ISO Nicotine results in increased expression of PRPF38B mRNA CTD PMID:16949557 NCBI chr 2:199,241,312...199,250,342
Ensembl chr 2:196,553,225...196,562,250
JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 increases splicing ISO Nicotine results in increased splicing of PRPS1 mRNA alternative form CTD PMID:23825647 NCBI chr  X:108,920,663...108,942,713
Ensembl chr  X:104,132,141...104,154,187
JBrowse link
G Prr18 proline rich 18 decreases expression ISO Nicotine results in decreased expression of PRR18 mRNA CTD PMID:21955143 NCBI chr 1:54,947,775...54,951,558
Ensembl chr 1:52,400,215...52,404,309
JBrowse link
G Prrc2c proline-rich coiled-coil 2C increases expression ISO Nicotine results in increased expression of PRRC2C mRNA CTD PMID:16949557 NCBI chr13:77,537,226...77,606,926
Ensembl chr13:75,004,010...75,073,643
JBrowse link
G Prss1 serine protease 1 decreases expression ISO Nicotine results in decreased expression of PRSS1 mRNA CTD PMID:16949557 NCBI chr 4:71,331,249...71,334,452
Ensembl chr 4:70,364,586...70,367,792
JBrowse link
G Psmb6 proteasome 20S subunit beta 6 decreases expression ISO Nicotine results in decreased expression of PSMB6 mRNA CTD PMID:18247414 NCBI chr10:55,737,852...55,740,218
Ensembl chr10:55,239,241...55,241,586
JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMC2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PSMC2 mRNA] CTD PMID:20230807 NCBI chr 4:14,148,080...14,162,390
Ensembl chr 4:13,255,856...13,270,185
JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 decreases expression ISO Nicotine results in decreased expression of PSMC4 mRNA CTD PMID:17456735 NCBI chr 1:92,476,690...92,485,268
Ensembl chr 1:83,348,592...83,357,494
JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMC5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PSMC5 mRNA] CTD PMID:20230807 NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,187,743...91,213,135
JBrowse link
G Psmg1 proteasome assembly chaperone 1 decreases expression ISO Nicotine results in decreased expression of PSMG1 mRNA CTD PMID:17997037 NCBI chr11:48,745,581...48,755,040
Ensembl chr11:35,276,011...35,285,622
JBrowse link
G Psmg2 proteasome assembly chaperone 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMG2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PSMG2 mRNA] CTD PMID:20230807 NCBI chr18:63,478,620...63,493,193
Ensembl chr18:61,208,678...61,259,816
JBrowse link
G Ptafr platelet-activating factor receptor decreases expression
increases expression
ISO Nicotine results in decreased expression of PTAFR mRNA
Nicotine results in increased expression of PTAFR mRNA
CTD PMID:18247414 PMID:23825647 NCBI chr 5:150,049,322...150,079,060
Ensembl chr 5:144,765,976...144,795,251
JBrowse link
G Ptbp2 polypyrimidine tract binding protein 2 increases expression ISO Nicotine results in increased expression of PTBP2 mRNA CTD PMID:16949557 NCBI chr 2:210,497,610...210,558,497
Ensembl chr 2:207,812,920...207,873,506
JBrowse link
G Pten phosphatase and tensin homolog increases expression EXP Nicotine results in increased expression of PTEN mRNA CTD PMID:11478936 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptges prostaglandin E synthase decreases expression ISO Nicotine results in decreased expression of PTGES mRNA; Nicotine results in decreased expression of PTGES protein CTD PMID:24380835 NCBI chr 3:34,575,643...34,586,987 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
increases activity
ISO
EXP
[4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [Nicotine results in increased abundance of Dinoprostone]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2]; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein; [U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of PTGS2]; Curcumin inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of PTGS2 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; Propranolol inhibits the reaction [Nicotine results in increased activity of PTGS2 protein]; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein]; Staurosporine inhibits the reaction [Nicotine results in increased expression of PTGS2]
Nicotine results in increased expression of PTGS2 mRNA; Nicotine results in increased expression of PTGS2 protein
Acetylcysteine inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; ferulic acid inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]
CTD PMID:16254210 PMID:17003101 PMID:17369603 PMID:17456735 PMID:18068289 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of PTK2 protein CTD PMID:30259641 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA] CTD PMID:12588870 NCBI chr 3:138,103,261...138,212,835
Ensembl chr 3:117,650,183...117,759,728
JBrowse link
G Ptx3 pentraxin 3 decreases expression ISO Nicotine results in decreased expression of PTX3 mRNA CTD PMID:18247414 NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:150,487,513...150,493,323
JBrowse link
G Pvalb parvalbumin decreases expression ISO Nicotine results in decreased expression of PVALB mRNA CTD PMID:21955143 NCBI chr 7:111,653,820...111,668,469
Ensembl chr 7:109,772,593...109,784,561
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PYCARD mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PYCARD mRNA]
Nicotine results in increased expression of PYCARD mRNA
CTD PMID:20230807 PMID:39098741 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Qki QKI, KH domain containing RNA binding increases expression ISO Nicotine results in increased expression of QKI mRNA CTD PMID:17997037 NCBI chr 1:52,935,357...53,047,338
Ensembl chr 1:50,387,698...50,498,831
JBrowse link
G Rab2a RAB2A, member RAS oncogene family multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RAB2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAB2 mRNA] CTD PMID:20230807 NCBI chr 5:26,473,424...26,537,441
Ensembl chr 5:21,676,129...21,739,899
JBrowse link
G Rab6a RAB6A, member RAS oncogene family decreases expression ISO Nicotine results in decreased expression of RAB6A mRNA CTD PMID:12588870 NCBI chr 1:164,370,033...164,422,324
Ensembl chr 1:154,958,189...154,996,715
JBrowse link
G Rab7a RAB7A, member RAS oncogene family multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAB7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RAB7 mRNA] CTD PMID:20230807 NCBI chr 4:122,019,281...122,068,067
Ensembl chr 4:120,461,963...120,506,889
JBrowse link
G Rac2 Rac family small GTPase 2 increases expression ISO Nicotine results in increased expression of RAC2 mRNA CTD PMID:23825647 NCBI chr 7:111,981,825...112,009,201
Ensembl chr 7:110,116,260...110,128,720
JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAD1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD1 mRNA] CTD PMID:20230807 NCBI chr 2:61,188,755...61,196,868
Ensembl chr 2:59,461,607...59,469,689
JBrowse link
G Rad50 RAD50 double strand break repair protein increases expression
multiple interactions
ISO Nicotine results in increased expression of RAD50 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAD50 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD50 mRNA]
CTD PMID:16949557 PMID:20230807 NCBI chr10:38,310,147...38,362,100
Ensembl chr10:37,808,726...37,861,396
JBrowse link
G Raet1e retinoic acid early transcript 1E increases expression ISO Nicotine results in increased expression of RAET1E mRNA CTD PMID:23825647 NCBI chr 1:3,474,487...3,476,431
Ensembl chr 1:1,807,644...1,812,755
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions
affects localization
increases activity
ISO Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; Bungarotoxins inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]; SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]
Nicotine affects the localization of RAF1 protein
Nicotine results in increased activity of RAF1 protein
CTD PMID:15574422 PMID:16862215 PMID:17459420 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Ramp1 receptor activity modifying protein 1 multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in increased expression of RAMP1 protein CTD PMID:19910445 NCBI chr 9:99,213,031...99,263,696
Ensembl chr 9:91,781,285...91,816,151
JBrowse link
G Ramp2 receptor activity modifying protein 2 multiple interactions EXP [Cholecalciferol co-treated with Nicotine] results in increased expression of RAMP2 protein CTD PMID:19910445 NCBI chr10:86,689,148...86,690,956
Ensembl chr10:86,188,812...86,231,829
JBrowse link
G Ramp3 receptor activity modifying protein 3 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of RAMP3 mRNA
[Cholecalciferol co-treated with Nicotine] results in increased expression of RAMP3 protein
CTD PMID:19910445 PMID:21955143 NCBI chr14:85,741,314...85,758,813
Ensembl chr14:81,527,385...81,544,902
JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 increases expression EXP Nicotine results in increased expression of RAPGEF3 mRNA CTD PMID:11478936 NCBI chr 7:130,754,883...130,777,303
Ensembl chr 7:128,875,773...128,898,521
JBrowse link
G Rarg retinoic acid receptor, gamma decreases expression ISO Nicotine results in decreased expression of RARG mRNA CTD PMID:18247414 NCBI chr 7:135,246,427...135,268,889
Ensembl chr 7:133,367,833...133,390,177
JBrowse link
G Rasa3 RAS p21 protein activator 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RASA3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RASA3 mRNA] CTD PMID:20230807 NCBI chr16:82,557,556...82,671,527
Ensembl chr16:75,855,265...75,970,804
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases phosphorylation
increases expression
decreases expression
ISO 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in increased phosphorylation of RB1 protein]; Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; Bungarotoxins inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; MK-886 inhibits the reaction [Nicotine results in increased expression of RB1 protein modified form]; Nicotine inhibits the reaction [RB1 protein binds to BIRC5 promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RB1 protein binds to CDC6 promoter]; Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]; SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]
Nicotine results in decreased expression of RB1 protein
CTD PMID:15574422 PMID:16011614 PMID:16601104 PMID:16862215 PMID:18448488 More... NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RBBP4 mRNA; Nicotine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RBBP4 mRNA] CTD PMID:20230807 NCBI chr 5:146,940,207...146,959,501
Ensembl chr 5:141,638,421...141,675,284
Ensembl chr 2:141,638,421...141,675,284
JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RBBP5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RBBP5 mRNA] CTD PMID:20230807 NCBI chr13:46,464,389...46,494,244
Ensembl chr13:43,912,254...43,939,107
JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase multiple interactions
increases expression
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]
Nicotine results in increased expression of RBBP6 mRNA
CTD PMID:12588870 PMID:16949557 NCBI chr 1:186,934,563...186,966,852
Ensembl chr 1:177,503,313...177,535,678
JBrowse link
G Rbbp9 RB binding protein 9, serine hydrolase increases expression ISO Nicotine results in increased expression of RBBP9 mRNA CTD PMID:17997037 NCBI chr 3:152,378,426...152,392,370
Ensembl chr 3:131,925,341...131,932,156
JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 decreases expression ISO Nicotine results in decreased expression of RBCK1 mRNA CTD PMID:17997037 NCBI chr 3:161,249,389...161,266,321
Ensembl chr 3:140,789,080...140,806,005
JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 increases expression ISO Nicotine results in increased expression of RBFOX3 protein CTD PMID:20457658 NCBI chr10:104,218,940...104,655,863
Ensembl chr10:103,720,636...104,156,935
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 multiple interactions ISO Nicotine inhibits the reaction [RBL1 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL1 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:145,807,095...145,869,330
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions ISO Nicotine inhibits the reaction [RBL2 protein binds to CDC25A promoter]; Nicotine inhibits the reaction [RBL2 protein binds to CDC6 promoter] CTD PMID:16862215 NCBI chr19:32,049,690...32,096,467
Ensembl chr19:15,876,853...15,923,572
JBrowse link
G Rbm25 RNA binding motif protein 25 increases expression ISO Nicotine results in increased expression of RBM25 mRNA CTD PMID:16949557 NCBI chr 6:108,993,119...109,050,159
Ensembl chr 6:103,271,801...103,317,854
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
increases expression
affects localization
decreases expression
ISO
EXP
[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide co-treated with U 0126] inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of RELA protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; Nicotine affects the localization of and results in increased activity of RELA protein; Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]; U 0126 inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]
Nicotine affects the localization of RELA protein
Mecamylamine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; methyllycaconitine analog inhibits the reaction [Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]]; Nicotine inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [RELA protein binds to NFKB1 protein]]
Nicotine results in decreased expression of RELA mRNA; Nicotine results in decreased expression of RELA protein
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Nicotine results in decreased expression of RELA protein]; Nicotine affects the localization of and results in increased activity of RELA protein
CTD PMID:16254210 PMID:17135361 PMID:18448488 PMID:23810507 PMID:27984197 More... NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Reln reelin decreases expression EXP Nicotine results in decreased expression of RELN mRNA CTD PMID:28555334 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Rem2 RRAD and GEM like GTPase 2 decreases expression ISO Nicotine results in decreased expression of REM2 mRNA CTD PMID:21955143 NCBI chr15:31,903,972...31,908,451
Ensembl chr15:27,933,950...27,938,429
JBrowse link
G Retn resistin decreases expression EXP Nicotine results in decreased expression of RETN mRNA CTD PMID:32512034 NCBI chr12:6,508,653...6,511,115
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Rfxap regulatory factor X-associated protein decreases expression ISO Nicotine results in decreased expression of RFXAP mRNA CTD PMID:12588870 NCBI chr 2:141,158,214...141,162,397
Ensembl chr 2:139,008,055...139,012,259
JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO Nicotine results in increased expression of RGS1 mRNA CTD PMID:18247414 NCBI chr13:58,568,844...58,573,187
Ensembl chr13:56,018,554...56,022,984
JBrowse link
G Rgs13 regulator of G-protein signaling 13 decreases expression EXP Nicotine results in decreased expression of RGS13 mRNA CTD PMID:11478936 NCBI chr13:58,472,604...58,505,922
Ensembl chr13:55,922,395...55,955,648
JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RGS2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RGS2 mRNA]
Nicotine results in increased expression of RGS2 mRNA
CTD PMID:17456735 PMID:20230807 NCBI chr13:58,350,063...58,352,666
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Rhob ras homolog family member B increases expression ISO Nicotine results in increased expression of RHOB mRNA CTD PMID:17997037 NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Rig1 RNA sensor RIG-1 multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of RIGI mRNA] CTD PMID:31154625 NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:55,321,235...55,370,819
JBrowse link
G Rlbp1 retinaldehyde binding protein 1 increases expression ISO Nicotine results in increased expression of RLBP1 mRNA CTD PMID:17997037 NCBI chr 1:142,718,262...142,731,621
Ensembl chr 1:133,308,938...133,322,296
JBrowse link
G Rlf RLF zinc finger increases expression ISO Nicotine results in increased expression of RLF mRNA CTD PMID:16949557 NCBI chr 5:139,996,782...140,052,419
Ensembl chr 5:134,711,619...134,767,257
JBrowse link
G Rnd3 Rho family GTPase 3 increases splicing ISO Nicotine results in increased splicing of RND3 mRNA alternative form CTD PMID:23825647 NCBI chr 3:55,981,142...55,998,494
Ensembl chr 3:35,571,143...35,589,327
JBrowse link
G Rnf145 ring finger protein 145 decreases expression ISO Nicotine results in decreased expression of RNF145 mRNA CTD PMID:17456735 NCBI chr10:29,507,779...29,552,153
Ensembl chr10:29,011,548...29,050,781
JBrowse link
G Rph3a rabphilin 3A increases expression ISO Nicotine results in increased expression of RPH3A mRNA CTD PMID:21955143 NCBI chr12:41,203,004...41,279,536
Ensembl chr12:35,542,728...35,617,592
JBrowse link
G Rpl26 ribosomal protein L26 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RPL26 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RPL26 mRNA] CTD PMID:20230807 NCBI chr10:54,109,692...54,112,822
Ensembl chr10:53,610,421...53,613,966
JBrowse link
G Rpl5 ribosomal protein L5 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RPL5 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RPL5 mRNA] CTD PMID:20230807 NCBI chr14:1,988,792...1,995,236
Ensembl chr14:1,843,770...1,850,290
JBrowse link
G Rpl7a ribosomal protein L7A decreases expression ISO Nicotine results in decreased expression of RPL7A mRNA CTD PMID:18247414 NCBI chr 3:30,637,136...30,639,778
Ensembl chr 3:10,239,001...10,241,716
Ensembl chr18:10,239,001...10,241,716
JBrowse link
G Rps24 ribosomal protein S24 increases splicing ISO Nicotine results in increased splicing of RPS24 mRNA alternative form CTD PMID:23825647 NCBI chr16:95,429...101,146
Ensembl chr16:89,604...94,279
JBrowse link
G Rps25 ribosomal protein s25 increases expression ISO Nicotine results in increased expression of RPS25 mRNA CTD PMID:18247414 NCBI chr 8:53,630,333...53,632,810
Ensembl chr 8:44,733,029...44,737,271
Ensembl chr 8:44,733,029...44,737,271
JBrowse link
G Rps27a ribosomal protein S27a multiple interactions
decreases expression
ISO [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; [Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein CTD PMID:30272249 NCBI chr14:107,486,664...107,488,941
Ensembl chr14:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011
JBrowse link
G Rps5 ribosomal protein S5 decreases expression ISO Nicotine results in decreased expression of RPS5 mRNA CTD PMID:33640489 NCBI chr 1:82,610,965...82,615,262
Ensembl chr 1:73,538,776...73,543,073
JBrowse link
G Rps6 ribosomal protein S6 increases phosphorylation
multiple interactions
ISO Nicotine results in increased phosphorylation of RPS6 protein
Cholesterol inhibits the reaction [Nicotine results in increased phosphorylation of RPS6 protein]
CTD PMID:31629012 NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases phosphorylation
ISO [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased phosphorylation of RPS6KB1 protein; dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of RPS6KB1 protein]]; Nicotine promotes the reaction [Dextran Sulfate results in decreased phosphorylation of RPS6KB1 protein]
Nicotine results in increased phosphorylation of RPS6KB1 protein
CTD PMID:30259641 PMID:31926917 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 decreases expression EXP Nicotine results in decreased expression of RPS6KB2 mRNA CTD PMID:11478936 NCBI chr 1:210,880,824...210,887,556
Ensembl chr 1:201,451,265...201,458,078
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 affects response to substance ISO RPTOR gene SNP affects the susceptibility to Nicotine CTD PMID:18438686 NCBI chr10:105,376,943...105,675,416
Ensembl chr10:104,878,487...105,176,983
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of RSAD2 mRNA CTD PMID:37951547 NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:43,047,658...43,059,699
JBrowse link
G Rspo3 R-spondin 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RSPO3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RSPO3 mRNA] CTD PMID:20230807 NCBI chr 1:30,112,529...30,197,267
Ensembl chr 1:28,283,914...28,367,061
JBrowse link
G RT1-Bb RT1 class II, locus Bb multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of HLA-DQB1 mRNA CTD PMID:37951547 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 multiple interactions ISO Nicotine promotes the reaction [nickel chloride results in increased expression of HLA-F mRNA] CTD PMID:37951547 NCBI chr20:3,407,880...3,484,130 JBrowse link
G RT1-Da RT1 class II, locus Da multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of HLA-DRA mRNA CTD PMID:37951547 NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,512,911...4,518,455
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of HLA-DRB1 mRNA CTD PMID:37951547 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G Runx1t1 RUNX1 partner transcriptional co-repressor 1 decreases expression ISO Nicotine results in decreased expression of RUNX1T1 mRNA CTD PMID:18247414 NCBI chr 5:31,984,946...32,136,878
Ensembl chr 5:27,187,551...27,335,592
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions
increases expression
ISO
EXP
CHRNB2 promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]
Nicotine results in increased expression of RYR2 mRNA; Nicotine results in increased expression of RYR2 protein
CREB1 protein promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; Nicotine promotes the reaction [CREB1 protein modified form binds to RYR2 promoter]
CTD PMID:21113126 NCBI chr17:63,081,527...63,667,141
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G S100a10 S100 calcium binding protein A10 decreases expression ISO Nicotine results in decreased expression of S100A10 mRNA CTD PMID:18247414 NCBI chr 2:181,904,454...181,913,101
Ensembl chr 2:179,220,887...179,229,661
JBrowse link
G S100a14 S100 calcium binding protein A14 increases expression ISO Nicotine results in increased expression of S100A14 mRNA CTD PMID:23825647 NCBI chr 2:178,305,976...178,308,004
Ensembl chr 2:176,008,395...176,010,423
JBrowse link
G S100a2 S100 calcium binding protein A2 increases expression ISO Nicotine results in increased expression of S100A2 mRNA CTD PMID:23825647 NCBI chr 2:178,374,659...178,375,903 JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression ISO Nicotine results in decreased expression of S100A6 mRNA CTD PMID:33640489 NCBI chr 2:178,398,189...178,399,763
Ensembl chr 2:176,100,899...176,102,180
JBrowse link
G S100b S100 calcium binding protein B decreases expression ISO Nicotine results in decreased expression of S100B mRNA CTD PMID:21955143 NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 decreases expression ISO Nicotine results in decreased expression of S1PR1 mRNA CTD PMID:17997037 NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:203,621,587...203,629,681
JBrowse link
G Sap30l SAP30-like decreases expression ISO Nicotine results in decreased expression of SAP30L mRNA CTD PMID:17997037 NCBI chr10:42,480,201...42,488,139
Ensembl chr10:41,979,687...41,987,658
JBrowse link
G Sar1b secretion associated, Ras related GTPase 1B increases expression ISO Nicotine results in increased expression of SAR1B mRNA CTD PMID:17997037 NCBI chr10:36,525,365...36,555,009
Ensembl chr10:36,024,382...36,054,066
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Nicotine results in increased expression of SC5D mRNA CTD PMID:17456735 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:42,632,672...42,641,273
JBrowse link
G Scaf11 SR-related CTD-associated factor 11 increases expression ISO Nicotine results in increased expression of SCAF11 mRNA CTD PMID:16949557 NCBI chr 7:129,450,872...129,503,280
Ensembl chr 7:127,574,463...127,624,101
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of SCARB1 mRNA; Nicotine results in decreased expression of SCARB1 protein
GW 3965 inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; GW 3965 inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein]
CTD PMID:30036686 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Nicotine results in increased expression of SCD1 mRNA
Nicotine results in increased expression of SCD mRNA
CTD PMID:17997037 PMID:23825647 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Scg2 secretogranin II increases expression EXP Nicotine results in increased expression of SCG2 mRNA CTD PMID:1907749 NCBI chr 9:88,251,531...88,257,208
Ensembl chr 9:80,803,075...80,821,097
JBrowse link
G Sdc4 syndecan 4 increases expression ISO Nicotine results in increased expression of SDC4 mRNA CTD PMID:21955143 NCBI chr 3:173,574,239...173,592,923
Ensembl chr 3:153,154,896...153,173,580
JBrowse link
G Sec61g Sec61 translocon subunit gamma increases expression ISO Nicotine results in increased expression of SEC61G mRNA CTD PMID:16949557 NCBI chr14:95,113,083...95,119,458
Ensembl chr14:90,899,768...90,906,162
Ensembl chr 9:90,899,768...90,906,162
JBrowse link
G Senp6 SUMO specific peptidase 6 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SENP6 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SENP6 mRNA] CTD PMID:20230807 NCBI chr 8:89,868,115...89,951,803
Ensembl chr 8:80,989,052...81,067,170
JBrowse link
G Septin7 septin 7 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SEPTIN7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SEPTIN7 mRNA] CTD PMID:20230807 NCBI chr 8:31,995,597...32,059,069
Ensembl chr 8:23,716,030...23,783,243
JBrowse link
G Septin8 septin 8 decreases expression ISO Nicotine results in decreased expression of SEPTIN8 mRNA CTD PMID:21955143 NCBI chr10:38,185,454...38,214,502
Ensembl chr10:37,684,639...37,713,174
JBrowse link
G Serinc3 serine incorporator 3 increases expression ISO Nicotine results in increased expression of SERINC3 mRNA CTD PMID:16949557 NCBI chr 3:172,721,208...172,749,853
Ensembl chr 3:152,301,772...152,321,808
JBrowse link
G Serpinb1a serpin family B member 1A increases expression ISO Nicotine results in increased expression of SERPINB1A mRNA CTD PMID:21955143 NCBI chr17:31,799,446...31,807,853
Ensembl chr17:31,590,677...31,599,102
JBrowse link
G Serpine1 serpin family E member 1 increases secretion
increases expression
EXP
ISO
Nicotine results in increased secretion of SERPINE1 protein
Nicotine results in increased expression of SERPINE1 mRNA
CTD PMID:11166759 PMID:21596853 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Serpinf1 serpin family F member 1 decreases expression ISO Nicotine results in decreased expression of SERPINF1 mRNA
Nicotine results in decreased expression of SERPINF1 mRNA; Nicotine results in decreased expression of SERPINF1 protein
CTD PMID:21955143 PMID:26536586 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,249,708...60,262,646
JBrowse link
G Serpinh1 serpin family H member 1 decreases expression ISO Nicotine results in decreased expression of SERPINH1 mRNA CTD PMID:16949557 NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:153,643,510...153,650,801
JBrowse link
G Sertad4 SERTA domain containing 4 decreases expression ISO Nicotine results in decreased expression of SERTAD4 mRNA CTD PMID:21955143 NCBI chr13:106,889,019...106,899,777
Ensembl chr13:104,360,307...104,370,546
JBrowse link
G Sf3b6 splicing factor 3B, subunit 6 increases expression ISO Nicotine results in increased expression of SF3B6 mRNA CTD PMID:16949557 NCBI chr 6:33,545,495...33,554,537
Ensembl chr 6:27,826,029...27,835,156
JBrowse link
G Sfpq splicing factor proline and glutamine rich multiple interactions
increases expression
ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SFPQ mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SFPQ mRNA]
Nicotine results in increased expression of SFPQ mRNA
CTD PMID:17997037 PMID:20230807 NCBI chr 5:144,621,678...144,637,930
Ensembl chr 5:139,338,075...139,353,472
JBrowse link
G Sftpa1 surfactant protein A1 increases expression
multiple interactions
ISO Nicotine results in increased expression of SFTPA1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPA1 mRNA]
CTD PMID:9458815 NCBI chr16:17,042,264...17,045,770
Ensembl chr16:17,008,180...17,011,685
JBrowse link
G Sftpc surfactant protein C increases expression
multiple interactions
ISO Nicotine results in increased expression of SFTPC mRNA
[Nicotine co-treated with Quartz] results in increased expression of SFTPC protein; Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPC mRNA]
CTD PMID:9458815 PMID:36868510 NCBI chr15:52,006,274...52,009,324
Ensembl chr15:45,596,574...45,610,777
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Nicotine results in increased expression of SGK1 mRNA CTD PMID:17456735 PMID:21955143 NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 decreases expression ISO Nicotine results in decreased expression of SGPP1 mRNA CTD PMID:17997037 NCBI chr 6:100,161,024...100,182,214
Ensembl chr 6:94,425,339...94,446,534
JBrowse link
G Sh2d2a SH2 domain containing 2A increases expression ISO Nicotine results in increased expression of SH2D2A mRNA CTD PMID:23825647 NCBI chr 2:175,610,127...175,616,685
Ensembl chr 2:173,312,253...173,318,810
JBrowse link
G Sh3d19 SH3 domain containing 19 increases splicing ISO Nicotine results in increased splicing of SH3D19 mRNA alternative form CTD PMID:23825647 NCBI chr 2:173,654,234...173,814,030
Ensembl chr 2:171,356,251...171,515,561
JBrowse link
G Sh3kbp1 SH3 domain-containing kinase-binding protein 1 increases expression ISO Nicotine results in increased expression of SH3KBP1 mRNA CTD PMID:23825647 NCBI chr  X:38,686,530...39,031,658
Ensembl chr  X:34,877,866...35,222,747
JBrowse link
G Shox2 SHOX homeobox 2 decreases expression ISO Nicotine results in decreased expression of SHOX2 mRNA CTD PMID:21955143 NCBI chr 2:153,524,324...153,537,571
Ensembl chr 2:151,217,552...151,227,143
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 protein; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of CXCL8 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of IL1B protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein]
resveratrol inhibits the reaction [Nicotine results in decreased expression of SIRT1 mRNA]
CTD PMID:22687363 PMID:23199342 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor decreases expression ISO Nicotine results in decreased expression of SIVA1 mRNA CTD PMID:16949557 NCBI chr 6:137,526,416...137,530,790
Ensembl chr 6:131,705,323...131,709,690
JBrowse link
G Slbp stem-loop histone mRNA binding protein multiple interactions
decreases expression
ISO 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [Nicotine results in decreased expression of SLBP protein]; Bungarotoxins inhibits the reaction [Nicotine results in decreased expression of SLBP protein]; CHRNA7 affects the reaction [Nicotine results in decreased expression of SLBP protein]; CSNK2A1 affects the reaction [Nicotine results in decreased expression of SLBP protein]; Roscovitine inhibits the reaction [Nicotine results in decreased expression of SLBP protein]
Nicotine results in decreased expression of SLBP mRNA; Nicotine results in decreased expression of SLBP protein
CTD PMID:35929799 NCBI chr14:81,295,479...81,306,446
Ensembl chr14:77,071,632...77,081,906
JBrowse link
G Slc17a6 solute carrier family 17 member 6 decreases expression ISO
EXP
Nicotine results in decreased expression of SLC17A6 mRNA CTD PMID:21955143 PMID:28555334 NCBI chr 1:110,348,447...110,388,499
Ensembl chr 1:101,212,489...101,252,542
JBrowse link
G Slc18a3 solute carrier family 18 member A3 multiple interactions EXP Nicotine inhibits the reaction [Vanadium results in decreased expression of SLC18A3 protein]; Nicotine promotes the reaction [Bucladesine results in increased expression of SLC18A3 protein] CTD PMID:20361958 PMID:22119111 NCBI chr16:7,719,953...7,722,814 JBrowse link
G Slc19a1 solute carrier family 19 member 1 decreases expression ISO Nicotine results in decreased expression of SLC19A1 mRNA CTD PMID:19616087 NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,584,411...11,601,972
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases activity
multiple interactions
EXP Nicotine results in decreased activity of SLC1A1 protein
Tetradecanoylphorbol Acetate inhibits the reaction [Nicotine results in decreased activity of SLC1A1 protein]
CTD PMID:24355585 NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:226,549,842...226,630,402
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Nicotine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium] CTD PMID:27450509 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
affects response to substance
ISO Nicotine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
SLC22A2 gene SNP affects the susceptibility to Nicotine
CTD PMID:23770354 PMID:25143296 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc25a48 solute carrier family 25, member 48 decreases expression ISO Nicotine results in decreased expression of SLC25A48 mRNA CTD PMID:23825647 NCBI chr17:8,113,134...8,172,376
Ensembl chr17:8,121,175...8,160,748
JBrowse link
G Slc35a1 solute carrier family 35 member A1 increases expression ISO Nicotine results in increased expression of SLC35A1 mRNA CTD PMID:16949557 NCBI chr 5:54,021,896...54,044,677
Ensembl chr 5:49,225,602...49,248,335
JBrowse link
G Slc37a2 solute carrier family 37 member 2 increases expression ISO Nicotine results in increased expression of SLC37A2 mRNA CTD PMID:23825647 NCBI chr 8:45,134,596...45,160,551
Ensembl chr 8:36,946,930...36,971,482
JBrowse link
G Slc39a6 solute carrier family 39 member 6 increases expression ISO Nicotine results in increased expression of SLC39A6 mRNA CTD PMID:16949557 NCBI chr18:16,139,621...16,160,163
Ensembl chr18:15,864,875...15,885,417
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Nicotine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Nicotine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Slc5a7 solute carrier family 5 member 7 multiple interactions EXP Nicotine affects the reaction [Hemicholinium 3 binds to SLC5A7 protein] CTD PMID:21633116 NCBI chr 9:7,922,693...7,953,509
Ensembl chr 9:7,595,444...7,626,258
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
decreases expression
increases methylation
decreases activity
ISO
EXP
Nicotine inhibits the reaction [Paraquat results in decreased expression of SLC6A3 protein]
Nicotine results in decreased expression of SLC6A3 mRNA; Nicotine results in decreased expression of SLC6A3 protein
Nicotine results in increased methylation of SLC6A3 promoter
Nicotine results in decreased activity of SLC6A3 protein
Dihydro-beta-Erythroidine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein]; Mecamylamine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein]
CTD PMID:17227438 PMID:23999947 PMID:31945395 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc6a7 solute carrier family 6 member 7 decreases expression ISO Nicotine results in decreased expression of SLC6A7 mRNA CTD PMID:21955143 NCBI chr18:56,718,849...56,737,702
Ensembl chr18:54,448,464...54,467,319
JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO Nicotine results in increased expression of SLC7A5 mRNA CTD PMID:23825647 NCBI chr19:66,843,808...66,872,412
Ensembl chr19:49,935,220...49,963,823
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 increases expression ISO Nicotine results in increased expression of SLCO2A1 mRNA CTD PMID:23825647 NCBI chr 8:112,467,739...112,551,923
Ensembl chr 8:103,588,916...103,672,546
JBrowse link
G Smad1 SMAD family member 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMAD1 mRNA] CTD PMID:20230807 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:28,513,131...28,573,651
JBrowse link
G Smad2 SMAD family member 2 decreases expression EXP Nicotine results in decreased expression of SMAD2 mRNA; Nicotine results in decreased expression of SMAD2 protein CTD PMID:29660438 PMID:31299270 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases expression
ISO
EXP
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SMAD3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA]
Nicotine results in decreased expression of SMAD3 mRNA
Nicotine results in increased expression of and results in increased phosphorylation of SMAD3 protein
CTD PMID:20230807 PMID:22691361 PMID:29660438 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smad9 SMAD family member 9 increases expression ISO Nicotine results in increased expression of SMAD9 mRNA CTD PMID:18247414 NCBI chr 2:141,106,668...141,156,477
Ensembl chr 2:138,986,471...139,006,307
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SMPD3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMPD3 mRNA] CTD PMID:20230807 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:34,162,341...34,245,749
JBrowse link
G Snai1 snail family transcriptional repressor 1 increases expression
multiple interactions
increases response to substance
ISO
EXP
Nicotine results in increased expression of SNAI1 mRNA; Nicotine results in increased expression of SNAI1 protein
SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC1 protein]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 mRNA]; SNAI1 protein affects the reaction [Nicotine results in increased expression of HDAC2 protein]
SNAI1 results in increased susceptibility to Nicotine
SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA]; SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of NANOG mRNA]; SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]
CTD PMID:23219715 PMID:34245815 NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression
decreases expression
ISO
EXP
Nicotine results in increased expression of SNAI2 mRNA
Nicotine results in decreased expression of SNAI2 mRNA
CTD PMID:20339300 PMID:23219715 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Snapc3 small nuclear RNA activating complex, polypeptide 3 increases expression ISO Nicotine results in increased expression of SNAPC3 mRNA CTD PMID:16949557 NCBI chr 5:102,863,867...102,890,573
Ensembl chr 5:97,817,947...97,844,650
JBrowse link
G Snca synuclein alpha increases expression ISO Nicotine results in increased expression of SNCA mRNA CTD PMID:18247414 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sncg synuclein, gamma multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SNCG mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCG mRNA] CTD PMID:20230807 NCBI chr16:9,706,765...9,712,072
Ensembl chr16:9,700,514...9,705,368
JBrowse link
G Snord8 small nucleolar RNA, C/D box 8 multiple interactions ISO [Nicotine co-treated with Propylene Glycol co-treated with Glycerol co-treated with Flavoring Agents] results in increased expression of SNORD8 mRNA CTD PMID:28065790 NCBI chr15:27,391,331...27,391,440
Ensembl chr15:24,917,836...24,917,945
JBrowse link
G Snrk SNF related kinase decreases expression ISO Nicotine results in decreased expression of SNRK mRNA CTD PMID:17997037 NCBI chr 8:130,657,204...130,711,461
Ensembl chr 8:121,793,302...121,832,323
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP Nicotine results in increased expression of SOCS3 mRNA CTD PMID:29155039 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of SOD1 protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 mRNA; [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 protein
CTD PMID:16627626 PMID:29617909 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
multiple interactions
increases expression
ISO
EXP
Nicotine results in decreased expression of SOD2 protein
SOD2 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine]
[Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD2 protein
resveratrol inhibits the reaction [Nicotine results in decreased expression of SOD2 protein]
Nicotine results in increased expression of SOD2 protein
CTD PMID:18343235 PMID:22687363 PMID:28681937 PMID:29617909 PMID:29747151 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 multiple interactions
increases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA] CTD PMID:16949557 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Sost sclerostin increases expression ISO Nicotine results in increased expression of SOST mRNA CTD PMID:33640489 NCBI chr10:87,412,722...87,415,766
Ensembl chr10:86,911,517...86,915,561
JBrowse link
G Sowaha sosondowah ankyrin repeat domain family member A decreases expression ISO Nicotine results in decreased expression of SOWAHA mRNA CTD PMID:21955143 NCBI chr10:38,142,633...38,146,199
Ensembl chr10:37,643,444...37,645,102
JBrowse link
G Sox18 SRY-box transcription factor 18 decreases expression ISO Nicotine results in decreased expression of SOX18 mRNA CTD PMID:17456735 NCBI chr 3:189,163,000...189,164,802
Ensembl chr 3:168,785,490...168,787,290
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression EXP Nicotine results in decreased expression of SOX9 mRNA; Nicotine results in decreased expression of SOX9 protein CTD PMID:29660438 PMID:31299270 NCBI chr10:98,305,744...98,311,250
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [[GATA6 protein binds to SP1 protein] which binds to CHRNA7 protein]; Nicotine promotes the reaction [GATA4 protein binds to SP1 protein]; Nicotine promotes the reaction [GATA6 protein binds to GATA4 protein binds to SP1 protein binds to CHRNA7 promoter]; Nicotine promotes the reaction [GATA6 protein binds to SP1 protein] CTD PMID:24089524 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Spag9 sperm associated antigen 9 increases expression ISO Nicotine results in increased expression of SPAG9 mRNA CTD PMID:16949557 NCBI chr10:79,440,311...79,574,709
Ensembl chr10:78,943,479...79,077,797
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of SPP1 protein
Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein]
CTD PMID:11425648 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sprr2d small proline-rich protein 2D increases expression ISO Nicotine results in increased expression of SPRR2D mRNA CTD PMID:23825647 NCBI chr 2:180,565,685...180,566,282
Ensembl chr 2:177,870,434...177,870,679
JBrowse link
G Sptlc3 serine palmitoyltransferase, long chain base subunit 3 increases expression ISO Nicotine results in increased expression of SPTLC3 mRNA CTD PMID:23825647 NCBI chr 3:147,301,570...147,431,696
Ensembl chr 3:126,847,878...126,978,010
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO Nicotine promotes the reaction [Dextran Sulfate results in decreased expression of SQSTM1 protein]
Nicotine results in increased expression of SQSTM1 protein
dorsomorphin inhibits the reaction [Nicotine promotes the reaction [Dextran Sulfate results in decreased expression of SQSTM1 protein]]; Nicotine promotes the reaction [Dextran Sulfate results in decreased expression of SQSTM1 protein]
CTD PMID:31926917 PMID:33010382 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
increases phosphorylation
ISO ARRB1 protein affects the reaction [Nicotine results in increased phosphorylation of and results in increased activity of SRC protein]; Nicotine results in increased phosphorylation of and results in increased activity of SRC protein; RTKI cpd inhibits the reaction [Nicotine results in increased phosphorylation of SRC protein]; SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] CTD PMID:14569062 PMID:16862215 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
increases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of SREBF1 mRNA
Nicotine results in increased expression of SREBF1 mRNA
[Nicotine results in increased abundance of Cotinine] which results in increased expression of SREBF1 mRNA
CTD PMID:18247414 PMID:29155039 PMID:29617909 PMID:31622651 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srgap2 SLIT-ROBO Rho GTPase activating protein 2 decreases expression ISO Nicotine results in decreased expression of SRGAP2 mRNA CTD PMID:17997037 NCBI chr13:45,298,192...45,519,330
Ensembl chr13:42,745,947...42,967,058
JBrowse link
G Srp9 signal recognition particle 9 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SRP9 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SRP9 mRNA] CTD PMID:20230807 NCBI chr13:96,364,253...96,372,393
Ensembl chr13:93,832,580...93,840,720
JBrowse link
G Srpx2 sushi-repeat-containing protein, X-linked 2 increases expression ISO Nicotine results in increased expression of SRPX2 mRNA CTD PMID:23825647 NCBI chr  X:101,399,748...101,425,486
Ensembl chr  X:97,106,561...97,132,195
JBrowse link
G Sst somatostatin decreases expression ISO Nicotine results in decreased expression of SST mRNA CTD PMID:17997037 NCBI chr11:90,461,546...90,462,823
Ensembl chr11:76,956,896...76,958,173
JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 decreases expression ISO Nicotine results in decreased expression of ST8SIA3 mRNA CTD PMID:21955143 NCBI chr18:60,024,555...60,031,050
Ensembl chr18:57,754,347...57,760,839
JBrowse link
G Stac SH3 and cysteine rich domain increases expression ISO Nicotine results in increased expression of STAC mRNA CTD PMID:23825647 NCBI chr 8:120,409,165...120,531,394
Ensembl chr 8:111,530,800...111,654,008
JBrowse link
G Star steroidogenic acute regulatory protein increases methylation
multiple interactions
decreases expression
ISO
EXP
Nicotine results in increased methylation of STAR promoter
LMK-235 inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; LMK-235 inhibits the reaction [Nicotine results in decreased expression of STAR protein]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR protein]
Nicotine results in decreased expression of STAR mRNA; Nicotine results in decreased expression of STAR protein
Taurine inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Taurine inhibits the reaction [Nicotine results in decreased expression of STAR protein]
Nicotine results in decreased expression of STAR; Nicotine results in decreased expression of STAR mRNA; Nicotine results in decreased expression of STAR protein
trichostatin A inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]
CTD PMID:20498001 PMID:21971485 PMID:22265867 PMID:24709674 PMID:31846720 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Nicotine inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA] CTD PMID:31154625 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat2 signal transducer and activator of transcription 2 decreases expression ISO Nicotine results in decreased expression of STAT2 mRNA CTD PMID:18247414 NCBI chr 7:1,287,025...1,302,858
Ensembl chr 7:702,495...718,967
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
affects expression
increases response to substance
increases activity
ISO
EXP
[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide co-treated with U 0126] inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; [Nicotine co-treated with Lipopolysaccharides] results in increased phosphorylation of STAT3 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; CHRNA5 protein affects the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Hexamethonium inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [Cisplatin results in decreased activity of STAT3 protein]; Nicotine inhibits the reaction [Paclitaxel results in decreased activity of STAT3 protein]; Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]; Nicotine promotes the reaction [STAT3 protein binds to ZFP36 promoter]; Nicotine results in increased phosphorylation of and results in increased activity of STAT3 protein; Propranolol inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Staurosporine inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; U 0126 inhibits the reaction [Nicotine promotes the reaction [RELA protein binds to STAT3 protein modified form]]; U 0126 inhibits the reaction [Nicotine results in increased activity of STAT3 protein]; U 0126 inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]
[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form; Bungarotoxins inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Hexamethonium inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form]; methyllycaconitine inhibits the reaction [[Nicotine co-treated with Butylhydroxybutylnitrosamine] results in increased expression of STAT3 protein modified form]
Nicotine affects the expression of STAT3 mRNA
STAT3 protein results in increased susceptibility to Nicotine
HMOX1 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Nicotine inhibits the reaction [Quartz results in decreased phosphorylation of STAT3 protein]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; STAT3 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased phosphorylation of STAT3 protein]; ZFP36 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; zinc protoporphyrin inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]
STAT3 results in increased susceptibility to Nicotine
CTD PMID:18448488 PMID:20106947 PMID:20943775 PMID:21606497 PMID:24095726 More... NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions
decreases phosphorylation
ISO Cholesterol inhibits the reaction [Nicotine results in decreased phosphorylation of STAT5 protein] CTD PMID:31629012 PMID:31783125 NCBI chr10:86,285,859...86,310,187
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat5b signal transducer and activator of transcription 5B increases expression ISO Nicotine results in increased expression of STAT5B mRNA CTD PMID:18805435 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Stat6 signal transducer and activator of transcription 6 increases expression ISO Nicotine results in increased expression of STAT6 mRNA CTD PMID:18805435 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:63,479,642...63,498,495
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Nicotine results in increased expression of STC2 mRNA CTD PMID:16949557 NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Steap1 STEAP family member 1 increases expression ISO Nicotine results in increased expression of STEAP1 mRNA CTD PMID:23825647 NCBI chr 4:29,231,809...29,242,317
Ensembl chr 4:28,276,909...28,287,479
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression
multiple interactions
ISO Nicotine results in decreased expression of STIP1 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of STIP1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STIP1 mRNA]
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA]
CTD PMID:16949557 PMID:20230807 NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:204,178,932...204,228,476
JBrowse link
G Stk25 serine/threonine kinase 25 increases expression ISO Nicotine results in increased expression of STK25 mRNA CTD PMID:18247414 NCBI chr 9:101,609,218...101,621,458
Ensembl chr 9:94,161,836...94,174,244
JBrowse link
G Strip2 striatin interacting protein 2 decreases expression ISO Nicotine results in decreased expression of STRIP2 mRNA CTD PMID:21955143 NCBI chr 4:59,503,478...59,545,745
Ensembl chr 4:58,536,055...58,578,291
JBrowse link
G Stx4 syntaxin 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of STX4A mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STX4A mRNA] CTD PMID:20230807 NCBI chr 1:191,880,549...191,890,333
Ensembl chr 1:182,451,117...182,459,979
JBrowse link
G Stxbp3 syntaxin binding protein 3 increases expression ISO Nicotine results in increased expression of STXBP3 mRNA CTD PMID:16949557 NCBI chr 2:199,130,725...199,173,823
Ensembl chr 2:196,442,634...196,485,671
JBrowse link
G Sub1 SUB1 regulator of transcription increases expression ISO Nicotine results in increased expression of SUB1 mRNA CTD PMID:17456735 NCBI chr 2:62,735,379...62,747,545
Ensembl chr 2:61,005,666...61,020,436
Ensembl chr 2:61,005,666...61,020,436
JBrowse link
G Supt4h1 SPT4 homolog, DSIF elongation factor subunit decreases expression ISO Nicotine results in decreased expression of SUPT4H1 mRNA CTD PMID:18247414 NCBI chr10:73,036,560...73,042,821
Ensembl chr10:72,539,382...72,545,831
JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 decreases expression ISO Nicotine results in decreased expression of SYNE1 mRNA CTD PMID:21955143 NCBI chr 1:43,917,640...44,388,802
Ensembl chr 1:41,512,030...41,983,322
JBrowse link
G Syngr2 synaptogyrin 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SYNGR2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SYNGR2 mRNA] CTD PMID:20230807 NCBI chr10:103,528,599...103,533,167
Ensembl chr10:103,029,917...103,034,473
JBrowse link
G Synpo synaptopodin increases expression ISO Nicotine results in increased expression of SYNPO mRNA CTD PMID:23825647 NCBI chr18:56,326,369...56,347,359
Ensembl chr18:54,026,152...54,102,126
JBrowse link
G Syt3 synaptotagmin 3 increases methylation EXP Nicotine results in increased methylation of SYT3 gene CTD PMID:32994467 NCBI chr 1:104,017,341...104,032,046
Ensembl chr 1:94,881,247...94,895,246
JBrowse link
G Syt4 synaptotagmin 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SYT4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SYT4 mRNA] CTD PMID:20230807 NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,038,378...23,046,332
JBrowse link
G Syt9 synaptotagmin 9 decreases expression ISO Nicotine results in decreased expression of SYT9 mRNA CTD PMID:21955143 NCBI chr 1:170,687,666...170,868,146
Ensembl chr 1:161,275,734...161,455,007
JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 decreases methylation EXP Nicotine results in decreased methylation of TAB1 gene CTD PMID:35026373 NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:111,686,371...111,707,058
JBrowse link
G Tacr1 tachykinin receptor 1 decreases expression
increases expression
multiple interactions
EXP Nicotine results in decreased expression of TACR1 mRNA; Nicotine results in decreased expression of TACR1 protein
Nicotine results in increased expression of TACR1 mRNA; Nicotine results in increased expression of TACR1 protein
Mecamylamine inhibits the reaction [Nicotine results in increased expression of TACR1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of TACR1 protein]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 mRNA]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TACR1 protein]
CTD PMID:26524655 PMID:27329243 NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tada2b transcriptional adaptor 2B increases expression EXP Nicotine results in increased expression of TADA2B mRNA CTD PMID:27782041 NCBI chr14:78,503,939...78,523,715
Ensembl chr14:74,279,217...74,290,755
JBrowse link
G Tagln2 transgelin 2 decreases expression ISO Nicotine results in decreased expression of TAGLN2 mRNA CTD PMID:16949557 NCBI chr13:87,499,350...87,506,328
Ensembl chr13:84,967,009...84,973,972
JBrowse link
G Taok1 TAO kinase 1 increases expression ISO Nicotine results in increased expression of TAOK1 mRNA CTD PMID:16949557 NCBI chr10:62,871,198...62,989,049
Ensembl chr10:62,381,404...62,465,766
JBrowse link
G Tbxa2r thromboxane A2 receptor increases activity EXP Nicotine results in increased activity of TBXA2R protein CTD PMID:21316381 NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:8,383,378...8,388,176
JBrowse link
G Tent4a terminal nucleotidyltransferase 4A increases splicing ISO Nicotine results in increased splicing of TENT4A mRNA alternative form CTD PMID:23825647 NCBI chr 1:35,594,380...35,627,836
Ensembl chr 1:33,765,672...33,799,433
JBrowse link
G Tex264 testis expressed 264 decreases expression ISO Nicotine results in decreased expression of TEX264 mRNA CTD PMID:17997037 NCBI chr 8:116,174,517...116,201,578
Ensembl chr 8:107,295,806...107,323,232
JBrowse link
G Tf transferrin multiple interactions ISO [Nicotine co-treated with Glycerol co-treated with Propylene Glycol] results in increased secretion of TF protein CTD PMID:36372912 NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfdp1 transcription factor Dp-1 multiple interactions
increases expression
decreases expression
ISO MK-886 inhibits the reaction [Nicotine results in increased expression of TFDP1 protein]
Nicotine results in increased expression of TFDP1 mRNA
Nicotine results in decreased expression of TFDP1 mRNA
CTD PMID:17997037 PMID:18247414 PMID:20061081 NCBI chr16:82,864,220...82,903,166
Ensembl chr16:76,162,043...76,200,817
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 multiple interactions
increases expression
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of TFPI2 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of TFPI2 mRNA]
Nicotine results in increased expression of TFPI2 mRNA
CTD PMID:12588870 NCBI chr 4:32,936,462...32,941,385
Ensembl chr 4:31,982,178...31,986,600
JBrowse link
G Tfrc transferrin receptor increases expression
multiple interactions
ISO Nicotine results in increased expression of TFRC mRNA
[Nicotine co-treated with Propylene Glycol co-treated with Glycerol] results in increased expression of TFRC mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TFRC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TFRC mRNA]
CTD PMID:16949557 PMID:20230807 PMID:28065790 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
increases expression
affects expression
ISO
EXP
Nicotine results in decreased expression of TGFB1 mRNA
Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
Nicotine results in increased expression of TGFB1 mRNA
Nicotine affects the expression of TGFB1 mRNA
Nicotine results in decreased expression of TGFB1 mRNA; Nicotine results in decreased expression of TGFB1 protein
Nicotine results in increased expression of TGFB1 protein
CTD PMID:21237301 PMID:22691361 PMID:25280790 PMID:29660438 PMID:31299270 More... NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression EXP Nicotine results in decreased expression of TGFBR1 mRNA; Nicotine results in decreased expression of TGFBR1 protein CTD PMID:29660438 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression EXP Nicotine results in decreased expression of TGFBR2 mRNA CTD PMID:28555334 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions
ISO
EXP
Nicotine results in increased expression of TH mRNA; Nicotine results in increased expression of TH protein
[conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; [conotoxin AuIB co-treated with triethyl-(beta-4-stilbenoxyethyl)ammonium co-treated with ZM 241385] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with exoenzyme C3, Clostridium botulinum] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; conotoxin AuIB inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; conotoxin AuIB inhibits the reaction [Nicotine results in increased expression of TH mRNA]; exoenzyme C3, Clostridium botulinum inhibits the reaction [Nicotine results in increased expression of TH mRNA]; imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]; imidacloprid promotes the reaction [Nicotine results in increased expression of TH protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Nicotine results in increased expression of TH mRNA]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; triethyl-(beta-4-stilbenoxyethyl)ammonium inhibits the reaction [Nicotine results in increased expression of TH mRNA]; ZM 241385 inhibits the reaction [imidacloprid promotes the reaction [Nicotine results in increased expression of TH mRNA]]; ZM 241385 inhibits the reaction [Nicotine results in increased expression of TH mRNA]
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TH mRNA; [Nicotine co-treated with polylactic acid-polyglycolic acid copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]
[methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased expression of TH mRNA]
CTD PMID:17498763 PMID:19594327 PMID:20230807 PMID:23933227 PMID:28082123 More... NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thoc1 THO complex subunit 1 increases expression ISO Nicotine results in increased expression of THOC1 mRNA CTD PMID:16949557 NCBI chr18:1,253,041...1,291,956
Ensembl chr18:983,824...1,019,114
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression
increases expression
multiple interactions
ISO
EXP
Nicotine affects the expression of TIMP1 mRNA
Nicotine results in increased expression of TIMP1 mRNA
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP1 mRNA
CTD PMID:18986645 PMID:34153408 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression EXP Nicotine results in increased expression of TIMP2 mRNA CTD PMID:34153408 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 affects expression
multiple interactions
ISO Nicotine affects the expression of TIMP3 mRNA
[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIMP3 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TIMP3 mRNA]
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP3 mRNA
CTD PMID:18986645 PMID:20230807 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:17,521,919...17,571,839
JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 multiple interactions
decreases expression
affects expression
ISO
EXP
[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of TIMP4 mRNA
Nicotine results in decreased expression of TIMP4 protein
Nicotine affects the expression of TIMP4 mRNA
CTD PMID:18986645 PMID:28681937 NCBI chr 4:149,978,667...149,985,350
Ensembl chr 4:148,304,490...148,312,558
JBrowse link
G Tinagl1 tubulointerstitial nephritis antigen-like 1 increases expression ISO Nicotine results in increased expression of TINAGL1 mRNA CTD PMID:23825647 NCBI chr 5:147,797,884...147,807,925
Ensembl chr 5:142,513,714...142,523,720
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression ISO Nicotine results in increased expression of TIPARP mRNA CTD PMID:17456735 NCBI chr 2:152,063,769...152,090,414
Ensembl chr 2:149,753,682...149,780,327
JBrowse link
G Tirap TIR domain containing adaptor protein multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIRAP mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TIRAP mRNA] CTD PMID:20230807 NCBI chr 8:41,789,557...41,805,903
Ensembl chr 8:33,531,725...33,547,432
JBrowse link
G Tjp1 tight junction protein 1 decreases expression
multiple interactions
ISO
EXP
Nicotine results in decreased expression of TJP1 protein
[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein; [Saquinavir co-treated with Nicotine] results in decreased expression of TJP1 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]; Vitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of TJP1 protein]
CTD PMID:18844224 PMID:20722969 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP
ISO
Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 mRNA]
[Aerosols co-treated with Nicotine] results in increased expression of TLR4 mRNA
CTD PMID:27984197 PMID:33469865 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 increases expression ISO Nicotine results in increased expression of TMCC3 mRNA CTD PMID:21955143 NCBI chr 7:30,781,452...31,058,888
Ensembl chr 7:28,893,967...29,171,926
JBrowse link
G Tmem125 transmembrane protein 125 increases expression ISO Nicotine results in increased expression of TMEM125 mRNA CTD PMID:21955143 NCBI chr 5:137,348,545...137,349,949
Ensembl chr 5:132,059,554...132,079,297
Ensembl chr 5:132,059,554...132,079,297
JBrowse link
G Tmem163 transmembrane protein 163 decreases expression ISO Nicotine results in decreased expression of TMEM163 mRNA CTD PMID:21955143 NCBI chr13:41,520,595...41,693,938
Ensembl chr13:38,968,101...39,141,452
JBrowse link
G Tmem222 transmembrane protein 222 increases splicing ISO Nicotine results in increased splicing of TMEM222 mRNA alternative form CTD PMID:23825647 NCBI chr 5:150,749,746...150,763,031
Ensembl chr 5:145,465,847...145,484,491
JBrowse link
G Tmem41b transmembrane protein 41B increases expression ISO Nicotine results in increased expression of TMEM41B mRNA CTD PMID:16949557 NCBI chr 1:173,447,362...173,461,760
Ensembl chr 1:164,012,592...164,026,933
JBrowse link
G Tmem63a transmembrane protein 63a increases expression ISO Nicotine results in increased expression of TMEM63A mRNA CTD PMID:21955143 NCBI chr13:95,194,323...95,227,944
Ensembl chr13:92,663,968...92,696,183
JBrowse link
G Tmem97 transmembrane protein 97 increases expression ISO Nicotine results in increased expression of TMEM97 mRNA CTD PMID:17997037 NCBI chr10:63,936,276...63,945,359
Ensembl chr10:63,438,222...63,589,730
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
increases secretion
decreases expression
increases expression
increases degradation
ISO
EXP
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein; Bungarotoxins inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]]; methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF mRNA]]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Nicotine promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA]; SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein]; ZFP36 mRNA affects the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; ZFP36 mRNA affects the reaction [Nicotine results in increased degradation of TNF mRNA]
Nicotine affects the expression of TNF mRNA
Nicotine results in increased secretion of TNF protein
Nicotine results in decreased expression of TNF protein
Nicotine results in increased expression of TNF mRNA; Nicotine results in increased expression of TNF protein
[Nicotine results in increased abundance of Cotinine] which results in increased expression of TNF mRNA; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of TNF protein]; erdosteine inhibits the reaction [Nicotine results in increased expression of TNF protein]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of TNF mRNA]; Nicotine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Vitamin E inhibits the reaction [Nicotine results in increased expression of TNF protein]
Acetylcysteine inhibits the reaction [Nicotine results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of TNF protein]; Eugenol inhibits the reaction [Nicotine results in increased expression of TNF mRNA]; Eugenol inhibits the reaction [Nicotine results in increased secretion of TNF protein]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Nicotine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Nicotine inhibits the reaction [IFNG protein results in increased expression of TNF mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; STAT3 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; zinc protoporphyrin inhibits the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
CTD PMID:15135227 PMID:16254210 PMID:17216608 PMID:20426880 PMID:21237301 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression
multiple interactions
EXP Nicotine results in increased expression of TNFRSF11B mRNA
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of TNFRSF11B mRNA]
CTD PMID:29981921 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression
decreases expression
EXP
ISO
Nicotine results in increased expression of TNFRSF1A mRNA
Nicotine results in decreased expression of TNFRSF1A mRNA
CTD PMID:18247414 PMID:20426880 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression
multiple interactions
EXP Nicotine results in decreased expression of TNFSF11 mRNA
Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of TNFSF11 mRNA]
CTD PMID:29981921 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tnk2 tyrosine kinase, non-receptor, 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TNK2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNK2 mRNA] CTD PMID:20230807 NCBI chr11:81,619,795...81,659,074
Ensembl chr11:68,114,726...68,154,009
JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 increases expression ISO Nicotine results in increased expression of TOMM70A mRNA CTD PMID:21955143 NCBI chr11:56,847,837...56,886,302
Ensembl chr11:43,377,216...43,417,202
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 increases expression ISO Nicotine results in increased expression of TOPBP1 mRNA CTD PMID:16949557 NCBI chr 8:112,766,791...112,815,203
Ensembl chr 8:103,887,865...103,931,674
JBrowse link
G Tp53 tumor protein p53 decreases expression
increases expression
multiple interactions
affects response to substance
affects expression
ISO
EXP
Nicotine results in decreased expression of TP53 mRNA; Nicotine results in decreased expression of TP53 protein
Nicotine results in increased expression of TRP53 mRNA; Nicotine results in increased expression of TRP53 protein
Nicotine results in decreased expression of TRP53 protein
[Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TRP53 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TRP53 protein]; royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA]
Nicotine results in increased expression of TP53 mRNA
TP53 protein affects the susceptibility to Nicotine
Nicotine affects the expression of TP53 mRNA
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of TP53 protein]; [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of TP53 protein modified form]; Nicotine inhibits the reaction [Cisplatin results in increased expression of TP53 protein]; Nicotine inhibits the reaction [Gemcitabine results in increased expression of TP53 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased expression of TP53 protein]; Rosiglitazone inhibits the reaction [Nicotine results in decreased expression of TP53 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK8 protein]
Nicotine results in increased expression of TP53 protein
CTD PMID:10837795 PMID:15983034 PMID:16011614 PMID:16601104 PMID:18247414 More... NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Nicotine] results in increased expression of TRP53INP1 mRNA CTD PMID:20230807 NCBI chr 5:29,051,267...29,069,486
Ensembl chr 5:24,260,568...24,267,968
JBrowse link
G Tph2 tryptophan hydroxylase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPH2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPH2 mRNA] CTD PMID:20230807 NCBI chr 7:52,571,909...52,676,305
Ensembl chr 7:50,685,694...50,789,424
JBrowse link
G Tpp2 tripeptidyl peptidase 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPP2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPP2 mRNA] CTD PMID:20230807 NCBI chr 9:53,538,788...53,620,253
Ensembl chr 9:46,046,632...46,128,157
JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression ISO Nicotine results in increased expression of TPR mRNA CTD PMID:16949557 NCBI chr13:64,974,419...65,037,604
Ensembl chr13:62,424,312...62,487,496
JBrowse link
G Tra2a transformer 2 alpha increases expression ISO Nicotine results in increased expression of TRA2A mRNA CTD PMID:16949557 NCBI chr 4:79,551,699...79,570,621
Ensembl chr 4:78,220,883...78,239,712
JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 increases expression ISO Nicotine results in increased expression of TREM1 mRNA CTD PMID:23825647 NCBI chr 9:20,259,227...20,276,879
Ensembl chr 9:12,763,819...12,779,203
JBrowse link
G Trib2 tribbles pseudokinase 2 increases expression ISO Nicotine results in increased expression of TRIB2 mRNA CTD PMID:16949557 NCBI chr 6:44,274,762...44,299,139
Ensembl chr 6:38,545,975...38,569,370
JBrowse link
G Trim28 tripartite motif-containing 28 increases splicing ISO Nicotine results in increased splicing of TRIM28 mRNA alternative form CTD PMID:23825647 NCBI chr 1:82,724,842...82,731,566
Ensembl chr 1:73,652,709...73,659,380
JBrowse link
G Trip11 thyroid hormone receptor interactor 11 increases expression ISO Nicotine results in increased expression of TRIP11 mRNA CTD PMID:16949557 NCBI chr 6:126,760,263...126,832,619
Ensembl chr 6:120,998,733...121,067,781
JBrowse link
G Trnp1 TMF1-regulated nuclear protein 1 increases expression ISO Nicotine results in increased expression of TRNP1 mRNA CTD PMID:23825647 NCBI chr 5:150,990,312...150,997,148
Ensembl chr 5:145,706,094...145,713,272
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
affects response to substance
increases expression
increases activity
EXP Mecamylamine inhibits the reaction [Nicotine results in increased expression of TRPV1 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of TRPV1 protein]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 mRNA]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TRPV1 protein]
TRPV1 protein affects the susceptibility to Nicotine
Nicotine results in increased expression of TRPV1 mRNA; Nicotine results in increased expression of TRPV1 protein
Nicotine results in increased activity of TRPV1 protein
CTD PMID:19483072 PMID:26524655 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TSC22D1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TSC22D1 mRNA] CTD PMID:20230807 NCBI chr15:58,159,612...58,260,244
Ensembl chr15:51,749,510...51,850,958
JBrowse link
G Tshr thyroid stimulating hormone receptor increases expression ISO Nicotine results in increased expression of TSHR mRNA CTD PMID:18247414 NCBI chr 6:116,072,321...116,206,009
Ensembl chr 6:110,341,581...110,474,538
JBrowse link
G Tspo translocator protein multiple interactions ISO [Flumazenil binds to and results in decreased activity of TSPO protein] which results in decreased susceptibility to Nicotine CTD PMID:7862733 NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:114,720,188...114,730,450
JBrowse link
G Tuba4a tubulin, alpha 4A decreases expression ISO Nicotine results in decreased expression of TUBA4A mRNA CTD PMID:16949557 NCBI chr 9:84,158,871...84,174,041
Ensembl chr 9:76,709,614...76,713,918
JBrowse link
G Tubb4a tubulin, beta 4A class IVa decreases expression ISO Nicotine results in decreased expression of TUBB4A mRNA CTD PMID:21955143 NCBI chr 9:2,004,836...2,012,281
Ensembl chr 9:1,917,845...1,925,291
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO Nicotine results in decreased expression of TUBB mRNA CTD PMID:16949557 NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Tut4 terminal uridylyl transferase 4 increases expression ISO Nicotine results in increased expression of TUT4 mRNA CTD PMID:16949557 NCBI chr 5:128,354,975...128,535,288
Ensembl chr 5:123,203,003...123,306,465
JBrowse link
G Twf2 twinfilin actin-binding protein 2 decreases expression ISO Nicotine results in decreased expression of TWF2 mRNA CTD PMID:17997037 NCBI chr 8:115,723,980...115,737,025
Ensembl chr 8:106,845,253...106,858,298
JBrowse link
G Twist1 twist family bHLH transcription factor 1 increases expression
multiple interactions
ISO Nicotine results in increased expression of TWIST1 mRNA
Nicotine promotes the reaction [Quartz results in increased expression of TWIST1 protein]; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of TWIST1 protein]
CTD PMID:23219715 PMID:36868510 NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Txn1 thioredoxin 1 increases expression
multiple interactions
EXP
ISO
Nicotine results in increased expression of TXN1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased expression of TXN1 protein]; methyllycaconitine inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]]; methyllycaconitine inhibits the reaction [Nicotine results in increased expression of TXN1 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]
Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TXN1 protein]
CTD PMID:28082123 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txndc9 thioredoxin domain containing 9 increases expression ISO Nicotine results in increased expression of TXNDC9 mRNA CTD PMID:16949557 NCBI chr 9:47,707,628...47,717,761
Ensembl chr 9:40,211,412...40,384,279
Ensembl chr 9:40,211,412...40,384,279
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Nicotine results in increased expression of TXNIP mRNA CTD PMID:17456735 NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G U2surp U2 snRNP-associated SURP domain containing increases expression ISO Nicotine results in increased expression of U2SURP mRNA CTD PMID:16949557 NCBI chr 8:104,898,580...104,963,642
Ensembl chr 8:96,022,957...96,075,691
JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 increases expression
multiple interactions
ISO Nicotine results in increased expression of UBA2 protein
[Nicotine results in increased expression of UBA2 protein] which results in increased sumoylation of EEF2 protein
CTD PMID:21554491 NCBI chr 1:95,912,422...95,939,870
Ensembl chr 1:86,775,244...86,802,682
JBrowse link
G Ubb ubiquitin B multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UBB mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of UBB mRNA] CTD PMID:20230807 NCBI chr10:47,746,923...47,748,628
Ensembl chr10:47,245,637...47,249,333
JBrowse link
G Ubc ubiquitin C multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UBC mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UBC mRNA] CTD PMID:20230807 NCBI chr12:36,899,673...36,905,275
Ensembl chr12:31,239,152...31,243,925
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C increases expression
decreases expression
multiple interactions
ISO Nicotine results in increased expression of UBE2C mRNA
Nicotine results in decreased expression of UBE2C mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE2C mRNA]
CTD PMID:16949557 PMID:23825647 NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of UBE2D2 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UBE2D2 mRNA] CTD PMID:20230807 NCBI chr18:27,638,399...27,680,386
Ensembl chr18:27,364,303...27,406,181
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I decreases expression ISO Nicotine results in decreased expression of UBE2I mRNA CTD PMID:18247414 NCBI chr10:14,782,245...14,802,911
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443
JBrowse link
G Ube3a ubiquitin protein ligase E3A multiple interactions
decreases expression
ISO Mecamylamine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA]; Nicotine inhibits the reaction [alpha-cobratoxin results in decreased expression of UBE3A mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA] CTD PMID:12588870 NCBI chr 1:119,204,244...119,297,097
Ensembl chr 1:110,070,480...110,157,250
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of UCHL1 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UCHL1 mRNA] CTD PMID:20230807 NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,485,031...41,495,590
JBrowse link
G Ucp1 uncoupling protein 1 decreases expression
multiple interactions
EXP
ISO
Nicotine results in decreased expression of UCP1 mRNA; Nicotine results in decreased expression of UCP1 protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 mRNA; [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of UCP1 protein
CTD PMID:33091441 NCBI chr19:41,713,350...41,721,421
Ensembl chr19:24,808,783...24,816,852
JBrowse link
G Ufm1 ubiquitin-fold modifier 1 increases expression ISO Nicotine results in increased expression of UFM1 mRNA CTD PMID:16949557 NCBI chr 2:140,119,722...140,127,866
Ensembl chr 2:137,966,678...137,978,089
Ensembl chr 2:137,966,678...137,978,089
JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 increases expression ISO Nicotine results in increased expression of UGP2 mRNA CTD PMID:18247414 NCBI chr14:99,657,637...99,698,573
Ensembl chr14:95,456,330...95,496,830
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Nicotine CTD PMID:14570768 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation
decreases expression
ISO UGT1A4 protein results in increased glucuronidation of Nicotine
Nicotine results in decreased expression of UGT1A5 mRNA
CTD PMID:14570768 PMID:16141602 PMID:21955143 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Nicotine CTD PMID:14570768 PMID:16141602 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Unc119 unc-119 lipid binding chaperone decreases expression ISO Nicotine results in decreased expression of UNC119 mRNA CTD PMID:16949557 NCBI chr10:63,735,927...63,741,404
Ensembl chr10:63,237,903...63,243,339
JBrowse link
G Unc45b unc-45 myosin chaperone B decreases expression EXP Nicotine results in decreased expression of UNC45B mRNA CTD PMID:27782041 NCBI chr10:68,343,011...68,370,683
Ensembl chr10:67,845,462...67,873,389
JBrowse link
G Unc5b unc-5 netrin receptor B increases expression ISO Nicotine results in increased expression of UNC5B mRNA CTD PMID:23825647 NCBI chr20:29,240,639...29,307,270
Ensembl chr20:28,697,726...28,764,537
JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO Nicotine results in increased expression of UPP1 mRNA CTD PMID:23825647 NCBI chr14:88,023,155...88,043,036
Ensembl chr14:83,809,960...83,829,462
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 decreases expression EXP Nicotine results in decreased expression of UQCRC2 protein CTD PMID:28681937 NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:175,167,894...175,199,453
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 decreases expression ISO Nicotine results in decreased expression of UQCRFS1 mRNA CTD PMID:18247414 NCBI chr17:34,173,787...34,190,952
Ensembl chr17:33,977,921...33,982,479
JBrowse link
G Uri1 URI1, prefoldin-like chaperone increases expression ISO Nicotine results in increased expression of URI1 mRNA CTD PMID:17997037 NCBI chr 1:99,783,157...99,845,787
Ensembl chr 1:90,646,393...90,709,026
JBrowse link
G Uros uroporphyrinogen III synthase multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UROS mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UROS mRNA] CTD PMID:20230807 NCBI chr 1:197,920,827...197,943,183
Ensembl chr 1:188,490,323...188,512,249
JBrowse link
G Vamp4 vesicle-associated membrane protein 4 increases expression ISO Nicotine results in increased expression of VAMP4 mRNA CTD PMID:17997037 NCBI chr13:77,453,135...77,475,909
Ensembl chr13:74,919,880...74,933,686
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Nicotine results in increased expression of VCAM1 mRNA CTD PMID:11166759 PMID:16254210 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vcan versican increases expression ISO Nicotine results in increased expression of VCAN mRNA CTD PMID:23825647 NCBI chr 2:22,497,035...22,595,955
Ensembl chr 2:20,761,718...20,860,637
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
decreases expression
multiple interactions
increases secretion
affects response to substance
decreases secretion
ISO
EXP
Nicotine results in increased expression of VEGFA mRNA; Nicotine results in increased expression of VEGFA protein
Nicotine results in decreased expression of VEGFA protein
[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA
Nicotine results in increased secretion of VEGFA protein
Nicotine affects the susceptibility to VEGFA
Nicotine results in decreased secretion of VEGFA protein
CHRNA5 mutant form inhibits the reaction [Nicotine results in increased expression of VEGFA protein]; EIF4E protein affects the reaction [Nicotine results in increased expression of VEGFA protein]
CTD PMID:14569062 PMID:16499655 PMID:20426880 PMID:20457658 PMID:21378373 More... NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin decreases expression
multiple interactions
increases expression
ISO Nicotine results in decreased expression of VIM mRNA
Nicotine promotes the reaction [Quartz results in increased expression of VIM protein]; staurosporine aglycone inhibits the reaction [[Nicotine co-treated with Quartz] results in increased expression of VIM protein]
Nicotine results in increased expression of VIM mRNA; Nicotine results in increased expression of VIM protein
CTD PMID:18247414 PMID:18844224 PMID:23219715 PMID:36868510 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Vps28 VPS28 subunit of ESCRT-I multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of VPS28 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of VPS28 mRNA] CTD PMID:20230807 NCBI chr 7:110,222,638...110,226,486
Ensembl chr 7:108,341,989...108,345,837
JBrowse link
G Vps41 VPS41 subunit of HOPS complex multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of VPS41 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of VPS41 mRNA] CTD PMID:20230807 NCBI chr17:50,758,732...50,923,129
Ensembl chr17:46,063,124...46,227,791
JBrowse link
G Vrk2 VRK serine/threonine kinase 2 decreases expression ISO Nicotine results in decreased expression of VRK2 mRNA CTD PMID:23825647 NCBI chr14:104,514,815...104,635,549
Ensembl chr14:100,313,601...100,434,527
JBrowse link
G Vwf von Willebrand factor increases expression
decreases expression
ISO Nicotine results in increased expression of VWF mRNA
Nicotine results in decreased expression of VWF mRNA
CTD PMID:11166759 PMID:17456735 NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:158,360,152...158,491,539
JBrowse link
G Wbp4 WW domain binding protein 4 multiple interactions ISO [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of WBP4 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of WBP4 mRNA] CTD PMID:20230807 NCBI chr15:61,271,774...61,299,740
Ensembl chr15:54,862,843...54,890,647
JBrowse link
G Wnt4 Wnt family member 4 increases expression
multiple interactions
ISO Nicotine results in increased expression of WNT4 mRNA; Nicotine results in increased expression of WNT4 protein
Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of WNT4 mRNA]; Carbon Tetrachloride promotes the reaction [Nicotine results in increased expression of WNT4 protein]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of WNT4 mRNA]; Nicotine promotes the reaction [Carbon Tetrachloride results in increased expression of WNT4 protein]
CTD PMID:33640489 PMID:35411647 NCBI chr 5:154,797,245...154,818,565
Ensembl chr 5:149,514,018...149,532,859
JBrowse link
G Wnt7b Wnt family member 7B increases expression ISO Nicotine results in increased expression of WNT7B mRNA CTD PMID:23825647 NCBI chr 7:118,514,684...118,559,316
Ensembl chr 7:116,634,814...116,679,581
JBrowse link
G Xaf1 XIAP associated factor 1 multiple interactions ISO [nickel chloride co-treated with Nicotine] results in increased expression of XAF1 mRNA CTD PMID:37951547 NCBI chr10:57,415,935...57,428,348
Ensembl chr10:56,917,121...56,929,770
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP Nicotine inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA] CTD PMID:18477628 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases activity
EXP Sodium Acetate inhibits the reaction [Nicotine results in increased activity of XDH protein] CTD PMID:31857090 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
increases expression
ISO [Nicotine co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of XIAP protein; Curcumin inhibits the reaction [Nicotine results in increased expression of XIAP protein]; Hexamethonium affects the reaction [Nicotine results in increased expression of XIAP protein]
Nicotine results in increased expression of XIAP mRNA; Nicotine results in increased expression of XIAP protein
CTD PMID:16601104 PMID:18676776 PMID:20727180 PMID:21267677 PMID:30259641 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Xist X inactive specific transcript increases expression ISO Nicotine results in increased expression of XIST mRNA CTD PMID:16949557 NCBI chr  X:72,540,753...72,558,266 JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO XRCC1 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine] CTD PMID:29747151 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:80,141,207...80,168,701
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase increases expression ISO Nicotine results in increased expression of YES1 mRNA CTD PMID:16949557 NCBI chr 9:120,646,657...120,753,880
Ensembl chr 9:113,200,256...113,299,837
JBrowse link
G Yipf4 Yip1 domain family, member 4 decreases expression ISO Nicotine results in decreased expression of YIPF4 mRNA CTD PMID:17997037 NCBI chr 6:26,702,647...26,714,066
Ensembl chr 6:20,950,501...20,962,229
JBrowse link
G Zc3h7a zinc finger CCCH type containing 7 A increases splicing ISO Nicotine results in increased splicing of ZC3H7A mRNA alternative form CTD PMID:23825647 NCBI chr10:4,980,147...5,019,637
Ensembl chr10:4,473,203...4,512,665
JBrowse link
G Zcchc7 zinc finger CCHC-type containing 7 increases expression ISO Nicotine results in increased expression of ZCCHC7 mRNA CTD PMID:17997037 NCBI chr 5:63,787,292...63,968,960
Ensembl chr 5:58,993,290...59,173,300
JBrowse link
G Zcchc9 zinc finger CCHC-type containing 9 increases expression ISO Nicotine results in increased expression of ZCCHC9 mRNA CTD PMID:16949557 NCBI chr 2:24,773,319...24,783,339
Ensembl chr 2:23,038,317...23,048,217
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO Nicotine results in increased expression of ZEB1 mRNA CTD PMID:16949557 NCBI chr17:56,644,397...56,811,155
Ensembl chr17:51,948,948...52,115,214
JBrowse link
G Zfp146 zinc finger protein 146 increases expression ISO Nicotine results in increased expression of ZNF146 mRNA CTD PMID:16949557 NCBI chr 1:94,537,054...94,549,315
Ensembl chr 1:85,409,373...85,436,275
JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions
increases response to substance
increases expression
increases activity
ISO [Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA; [Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 protein; Bungarotoxins inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; methyllycaconitine inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; Nicotine promotes the reaction [STAT3 protein binds to ZFP36 promoter]; ZFP36 mRNA affects the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; ZFP36 mRNA affects the reaction [Nicotine results in increased degradation of TNF mRNA]
ZFP36 protein results in increased susceptibility to Nicotine
[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA; HMOX1 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]; HMOX1 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [Nicotine results in increased expression of ZFP36 mRNA]; tin protoporphyrin IX inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of CCL2 mRNA]; ZFP36 mutant form inhibits the reaction [Nicotine results in decreased expression of IL6 mRNA]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; ZFP36 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; ZFP36 protein promotes the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; zinc protoporphyrin inhibits the reaction [[Nicotine co-treated with Lipopolysaccharides] results in increased expression of ZFP36 mRNA]; zinc protoporphyrin inhibits the reaction [Nicotine results in increased expression of ZFP36 mRNA]
Nicotine results in increased expression of ZFP36 mRNA; Nicotine results in increased expression of ZFP36 protein
Nicotine results in increased activity of ZFP36 promoter
CTD PMID:21606497 PMID:22093924 PMID:24095726 NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:83,669,084...83,671,564
JBrowse link
G Zfp42 zinc finger protein 42 multiple interactions
increases expression
ISO Tubocurarine inhibits the reaction [Nicotine results in increased expression of ZFP42 mRNA] CTD PMID:15749260 NCBI chr16:55,568,903...55,577,883
Ensembl chr16:48,836,648...48,845,401
Ensembl chr 4:48,836,648...48,845,401
JBrowse link
G Zfp605 zinc finger protein 605 increases expression ISO Nicotine results in increased expression of ZNF605 mRNA CTD PMID:16949557 NCBI chr12:52,202,487...52,234,782
Ensembl chr12:46,545,073...46,575,828
JBrowse link
G Zfr zinc finger RNA binding protein multiple interactions
decreases expression
ISO alpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA] CTD PMID:12588870 NCBI chr 2:62,864,333...62,927,377
Ensembl chr 2:61,137,611...61,200,322
JBrowse link
G Zic1 Zic family member 1 increases expression ISO Nicotine results in increased expression of ZIC1 mRNA CTD PMID:21955143 NCBI chr 8:100,785,282...100,797,716
Ensembl chr 8:91,908,576...91,912,731
JBrowse link
G Zmynd8 zinc finger, MYND-type containing 8 increases expression ISO Nicotine results in increased expression of ZMYND8 mRNA CTD PMID:16949557 NCBI chr 3:174,948,162...175,061,382
Ensembl chr 3:154,529,043...154,628,463
JBrowse link
G Znrf1 zinc and ring finger 1 decreases expression ISO Nicotine results in decreased expression of ZNRF1 mRNA CTD PMID:17997037 NCBI chr19:56,403,816...56,490,901
Ensembl chr19:39,496,527...39,580,969
JBrowse link
nitenpyram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt2 AKT serine/threonine kinase 2 decreases expression ISO nitenpyram results in decreased expression of AKT2 mRNA CTD PMID:35568224 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Akt3 AKT serine/threonine kinase 3 decreases expression ISO nitenpyram results in decreased expression of AKT3 mRNA CTD PMID:35568224 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:88,946,091...89,225,708
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO nitenpyram results in increased expression of ATM mRNA CTD PMID:35568224 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atr ATR serine/threonine kinase decreases expression ISO nitenpyram results in decreased expression of ATR mRNA CTD PMID:35568224 NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO nitenpyram results in increased expression of BAX mRNA CTD PMID:35568224 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Cd36 CD36 molecule increases expression ISO nitenpyram results in increased expression of CD36 mRNA CTD PMID:35568224 NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO nitenpyram results in increased expression of CDKN1A mRNA CTD PMID:35568224 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP nitenpyram results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein] CTD PMID:16981889 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Egf epidermal growth factor decreases expression ISO nitenpyram results in decreased expression of EGF mRNA CTD PMID:35568224 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression ISO nitenpyram results in decreased expression of GADD45A mRNA CTD PMID:35568224 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G H2ax H2A.X variant histone increases expression ISO nitenpyram results in increased expression of H2AX mRNA CTD PMID:35568224 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO nitenpyram results in increased expression of MDM2 mRNA CTD PMID:35568224 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases activity ISO nitenpyram results in increased activity of SLC22A1 protein CTD PMID:31364238 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO nitenpyram results in decreased activity of SLC22A2 protein CTD PMID:31364238 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases activity ISO nitenpyram results in increased activity of SLCO2B1 protein CTD PMID:31364238 NCBI chr 1:163,371,410...163,419,412
Ensembl chr 1:153,959,293...154,007,353
JBrowse link
G Tp53 tumor protein p53 increases expression ISO nitenpyram results in increased expression of TP53 mRNA CTD PMID:35568224 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
sulfoxaflor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity
multiple interactions
EXP sulfoxaflor results in decreased activity of CAT protein
Resveratrol affects the reaction [sulfoxaflor results in decreased activity of CAT protein]
CTD PMID:33733559 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of CD3E mRNA
Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of CD3E mRNA]
CTD PMID:33733559 NCBI chr 8:54,200,617...54,211,770
Ensembl chr 8:45,303,852...45,315,022
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr 3:78,862,286...78,877,353
Ensembl chr 3:58,454,744...58,469,840
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases activity ISO sulfoxaflor results in increased activity of CHRNA7 protein; sulfoxaflor results in increased activity of CHRNA7 protein mutant form CTD PMID:39393466 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr10:54,999,943...55,015,137
Ensembl chr10:54,501,093...54,516,345
JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr 9:95,310,316...95,318,734
Ensembl chr 9:87,862,407...87,870,833
JBrowse link
G Chrng cholinergic receptor nicotinic gamma subunit multiple interactions EXP sulfoxaflor binds to and results in increased activity of [CHRNA1 protein binds to CHRNA1 protein binds to CHRNB1 protein binds to CHRNG protein binds to CHRND protein] CTD PMID:22461452 NCBI chr 9:87,878,085...87,884,193
Ensembl chr 9:87,878,085...87,914,482
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP sulfoxaflor results in increased expression of CYP2B1 mRNA CTD PMID:23607986 NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO NR1I2 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA] CTD PMID:23607986 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP sulfoxaflor results in increased expression of CYP3A23-3A1 mRNA CTD PMID:23607986 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
EXP Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of IFNG protein] CTD PMID:33733559 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of IL10 protein
Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of IL10 protein]
CTD PMID:33733559 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of IL1B protein
Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of IL1B protein]
CTD PMID:33733559 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of IL6 protein
Resveratrol affects the reaction [sulfoxaflor results in increased expression of IL6 protein]
CTD PMID:33733559 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of ITGAM mRNA
Resveratrol affects the reaction [sulfoxaflor results in increased expression of ITGAM mRNA]
CTD PMID:33733559 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases response to substance
ISO NR1I2 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA]; NR1I2 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP3A11 mRNA]
NR1I2 protein results in increased susceptibility to sulfoxaflor
CTD PMID:23607986 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases response to substance
ISO NR1I3 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [sulfoxaflor results in increased expression of CYP3A11 mRNA]
NR1I3 protein results in increased susceptibility to sulfoxaflor
CTD PMID:23607986 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP sulfoxaflor results in increased expression of TNF protein
Resveratrol inhibits the reaction [sulfoxaflor results in increased expression of TNF protein]
CTD PMID:33733559 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
thiacloprid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of ABCC2 mRNA CTD PMID:32745781 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression
ISO
EXP
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of ABCC3 mRNA
thiacloprid results in increased expression of ABCC3 mRNA
[thiacloprid co-treated with clothianidin] results in increased expression of ABCC3 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of ABCC3 mRNA
CTD PMID:32745781 PMID:33426623 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Ache acetylcholinesterase decreases activity EXP
ISO
thiacloprid results in decreased activity of ACHE protein CTD PMID:21251949 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of ACOX1 mRNA CTD PMID:32736067 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Alb albumin multiple interactions
decreases expression
EXP astaxanthine inhibits the reaction [thiacloprid results in decreased expression of ALB protein] CTD PMID:34564187 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression
multiple interactions
ISO
EXP
thiacloprid results in increased expression of ALDH1A1 mRNA
[thiacloprid co-treated with clothianidin] results in increased expression of ALDH1A1 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of ALDH1A1 mRNA
[thiacloprid co-treated with enilconazole] results in decreased expression of ALDH1A1 mRNA
CTD PMID:32201337 PMID:33426623 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Atg5 autophagy related 5 decreases expression ISO thiacloprid results in decreased expression of ATG5 mRNA; thiacloprid results in decreased expression of ATG5 protein CTD PMID:37468076 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Cat catalase decreases activity
multiple interactions
decreases expression
EXP thiacloprid results in decreased activity of CAT protein
astaxanthine inhibits the reaction [thiacloprid results in decreased activity of CAT protein]; Polysaccharides inhibits the reaction [thiacloprid results in decreased activity of CAT protein]; Polysaccharides inhibits the reaction [thiacloprid results in decreased expression of CAT mRNA]
CTD PMID:28692354 PMID:34564187 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CD36 mRNA CTD PMID:32736067 NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions ISO [clothianidin co-treated with thiacloprid] results in increased expression of CES2 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CES2 protein CTD PMID:32201337 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP thiacloprid results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]; thiacloprid results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein] CTD PMID:16981889 PMID:25459289 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CPT1A mRNA CTD PMID:32736067 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Crem cAMP responsive element modulator decreases expression ISO thiacloprid results in decreased expression of CREM mRNA; thiacloprid results in decreased expression of CREM protein CTD PMID:37468076 NCBI chr17:58,932,011...59,001,160
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression ISO thiacloprid results in increased expression of CYBB mRNA CTD PMID:32201337 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO thiacloprid results in decreased expression of CYP11A1 mRNA CTD PMID:37468076 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity
affects expression
multiple interactions
increases expression
ISO thiacloprid results in increased activity of CYP19A1 protein
thiacloprid affects the expression of CYP19A1 mRNA
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione affects the reaction [thiacloprid affects the expression of CYP19A1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [thiacloprid affects the expression of CYP19A1 mRNA]
thiacloprid results in increased expression of CYP19A1 mRNA
CTD PMID:26464060 PMID:28750898 PMID:29701941 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO thiacloprid results in increased expression of CYP1A1 mRNA; thiacloprid results in increased expression of CYP1A1 protein CTD PMID:21784029 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO thiacloprid results in increased expression of CYP1A2 mRNA; thiacloprid results in increased expression of CYP1A2 protein
[enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP1A2 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP1A2 mRNA
CTD PMID:21784029 PMID:32201337 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression
multiple interactions
EXP thiacloprid results in increased expression of CYP2B2 mRNA
[thiacloprid co-treated with clothianidin] results in increased expression of CYP2B2 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP2B2 mRNA
CTD PMID:33426623 NCBI chr 1:90,722,243...90,736,272
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO [clothianidin co-treated with thiacloprid] results in increased expression of CYP2B6 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CYP2B6 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CYP2B9 protein; [thiacloprid co-treated with enilconazole] results in increased expression of CYP2B6 mRNA
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of CYP2B10 mRNA; [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CYP2B10 mRNA
thiacloprid results in increased expression of CYP2B6 mRNA
CTD PMID:32201337 PMID:32736067 PMID:32745781 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CYP2C55 mRNA CTD PMID:32736067 NCBI chr 1:246,286,341...246,348,607
Ensembl chr 1:236,873,967...236,936,238
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases expression
multiple interactions
decreases expression
ISO thiacloprid results in increased expression of CYP2C19 mRNA
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of CYP2C29 mRNA
thiacloprid results in decreased expression of CYP2C19 protein
CTD PMID:32194361 PMID:32201337 PMID:32745781 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions
ISO thiacloprid results in decreased expression of CYP2E1 mRNA
[clothianidin co-treated with thiacloprid] results in increased expression of CYP2E1 protein; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of CYP2E1 mRNA
CTD PMID:32201337 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO thiacloprid results in increased expression of CYP3A4 mRNA; thiacloprid results in increased expression of CYP3A4 protein
[clothianidin co-treated with thiacloprid] results in increased expression of CYP3A4 protein; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP3A4 mRNA; [enilconazole co-treated with thiacloprid] results in increased expression of CYP3A4 protein; [thiacloprid co-treated with enilconazole] results in increased expression of CYP3A4 mRNA
CTD PMID:32201337 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
increases expression
EXP [thiacloprid co-treated with clothianidin] results in increased expression of CYP3A23-3A1 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP3A23-3A1 mRNA
thiacloprid results in increased expression of CYP3A23-3A1 mRNA
CTD PMID:33426623 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression
multiple interactions
ISO thiacloprid results in increased expression of CYP3A5 mRNA
[enilconazole co-treated with thiacloprid] results in increased expression of CYP3A5 protein; [thiacloprid co-treated with clothianidin] results in increased expression of CYP3A5 mRNA
CTD PMID:32201337 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions
ISO
EXP
thiacloprid results in decreased expression of CYP7A1 protein
thiacloprid results in decreased expression of CYP7A1 mRNA
[thiacloprid co-treated with clothianidin] results in decreased expression of CYP7A1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of CYP7A1 mRNA
CTD PMID:32194361 PMID:33426623 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ddx4 DEAD-box helicase 4 decreases expression ISO thiacloprid results in decreased expression of DDX4 mRNA; thiacloprid results in decreased expression of DDX4 protein CTD PMID:37468076 NCBI chr 2:45,961,174...46,016,097
Ensembl chr 2:44,227,946...44,282,723
JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of DIO1 mRNA CTD PMID:32745781 NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of ECI1 mRNA CTD PMID:32736067 NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,456,563...13,470,061
JBrowse link
G Eln elastin multiple interactions
decreases expression
EXP [thiacloprid co-treated with clothianidin] results in decreased expression of ELN mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of ELN mRNA
thiacloprid results in decreased expression of ELN mRNA
CTD PMID:33426623 NCBI chr12:27,604,983...27,648,413
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of GFAP protein CTD PMID:32736067 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions
EXP thiacloprid results in increased expression of GPT protein
astaxanthine inhibits the reaction [thiacloprid results in increased expression of GPT protein]; Polysaccharides inhibits the reaction [thiacloprid results in increased expression of GPT protein]
CTD PMID:31328355 PMID:34564187 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
decreases expression
EXP Polysaccharides inhibits the reaction [thiacloprid results in decreased expression of GPX1 mRNA] CTD PMID:28692354 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
increases expression
EXP astaxanthine inhibits the reaction [thiacloprid results in increased expression of HMGB1 mRNA] CTD PMID:34564187 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of HMGCS2 mRNA CTD PMID:32745781 NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
EXP thiacloprid results in increased expression of IL10 protein
astaxanthine inhibits the reaction [thiacloprid results in increased expression of IL10 protein]
CTD PMID:34564187 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP thiacloprid results in increased expression of IL1B protein
astaxanthine inhibits the reaction [thiacloprid results in increased expression of IL1B protein]
CTD PMID:34564187 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression EXP thiacloprid results in increased expression of IL6 protein CTD PMID:34564187 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins1 insulin 1 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of INS1 protein CTD PMID:32745781 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Ky kyphoscoliosis peptidase decreases expression
multiple interactions
EXP thiacloprid results in decreased expression of KY mRNA
[thiacloprid co-treated with clothianidin] results in decreased expression of KY mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of KY mRNA
CTD PMID:33426623 NCBI chr 8:111,965,862...112,005,206
Ensembl chr 8:103,086,630...103,126,024
JBrowse link
G Megf11 multiple EGF-like-domains 11 decreases expression
multiple interactions
EXP thiacloprid results in decreased expression of MEGF11 mRNA
[thiacloprid co-treated with clothianidin] results in decreased expression of MEGF11 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of MEGF11 mRNA
CTD PMID:33426623 NCBI chr 8:73,787,568...74,113,228
Ensembl chr 8:64,892,387...65,216,061
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO thiacloprid results in decreased expression of MKI67 mRNA; thiacloprid results in decreased expression of MKI67 protein CTD PMID:37468076 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mme membrane metallo-endopeptidase increases expression
multiple interactions
EXP thiacloprid results in increased expression of MME mRNA
[thiacloprid co-treated with clothianidin] results in increased expression of MME mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of MME mRNA
CTD PMID:33426623 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP thiacloprid results in increased expression of NOS2 mRNA
astaxanthine inhibits the reaction [thiacloprid results in increased expression of NOS2 mRNA]
CTD PMID:34564187 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the susceptibility to [2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with Thiophanate co-treated with thiacloprid co-treated with Ziram] CTD PMID:29950287 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of PDGFRB protein CTD PMID:32736067 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO thiacloprid results in increased expression of POR mRNA CTD PMID:32201337 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SERPINE1 mRNA CTD PMID:32745781 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SLC16A2 mRNA CTD PMID:32745781 NCBI chr  X:72,791,096...72,914,299
Ensembl chr  X:68,723,261...68,848,771
JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases activity ISO thiacloprid metabolite results in increased activity of SLC22A1 protein; thiacloprid results in increased activity of SLC22A1 protein CTD PMID:31364238 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO thiacloprid metabolite results in decreased activity of SLC22A2 protein; thiacloprid results in decreased activity of SLC22A2 protein CTD PMID:31364238 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity ISO thiacloprid metabolite results in decreased activity of SLC22A8 protein; thiacloprid results in decreased activity of SLC22A8 protein CTD PMID:31364238 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc6a1 solute carrier family 6 member 1 decreases expression
multiple interactions
EXP thiacloprid results in decreased expression of SLC6A1 mRNA
[thiacloprid co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of SLC6A1 mRNA
CTD PMID:33426623 NCBI chr 4:149,004,447...149,037,840
Ensembl chr 4:147,466,965...147,482,293
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
EXP Polysaccharides inhibits the reaction [thiacloprid results in decreased expression of SOD1 mRNA] CTD PMID:28692354 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO thiacloprid results in decreased expression of STAR mRNA CTD PMID:37468076 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 multiple interactions ISO [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SULT1B1 mRNA CTD PMID:32745781 NCBI chr14:20,771,917...20,784,665
Ensembl chr14:20,492,708...20,505,483
JBrowse link
G Sycp3 synaptonemal complex protein 3 decreases expression ISO thiacloprid results in decreased expression of SYCP3 mRNA; thiacloprid results in decreased expression of SYCP3 protein CTD PMID:37468076 NCBI chr 7:24,761,476...24,775,933
Ensembl chr 7:22,874,055...22,888,511
JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO [2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of THRSP mRNA; [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in decreased expression of THRSP mRNA; Dietary Fats inhibits the reaction [[2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of THRSP mRNA] CTD PMID:32745781 NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
thiamethoxam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases activity
EXP [fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of ALPL protein]
Thiamethoxam results in increased activity of ALPL protein
CTD PMID:30621503 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Anxa10 annexin A10 increases expression ISO Thiamethoxam results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:32,505,025...32,571,961
Ensembl chr16:27,738,712...27,805,648
JBrowse link
G Ar androgen receptor affects binding ISO Thiamethoxam binds to AR protein CTD PMID:31550567 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arg1 arginase 1 decreases expression ISO Thiamethoxam results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Thiamethoxam results in increased expression of ATF3 mRNA CTD PMID:33533595 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Thiamethoxam results in increased expression of BAX protein CTD PMID:33533595 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Thiamethoxam results in decreased expression of BCL2 protein CTD PMID:33533595 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl6 BCL6, transcription repressor decreases expression ISO Thiamethoxam results in decreased expression of BCL6 mRNA CTD PMID:33533595 NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Btg1 BTG anti-proliferation factor 1 increases expression ISO Thiamethoxam results in increased expression of BTG1 mRNA CTD PMID:33533595 NCBI chr 7:33,228,149...33,230,406
Ensembl chr 7:31,341,027...31,343,649
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Thiamethoxam results in increased cleavage of CASP3 protein CTD PMID:33533595 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase increases expression
decreases expression
multiple interactions
decreases activity
ISO
EXP
Thiamethoxam results in increased expression of CAT mRNA
Thiamethoxam results in decreased expression of CAT mRNA
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of CAT mRNA]
CTD PMID:30621503 PMID:33533595 PMID:34181816 PMID:36958429 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Thiamethoxam results in increased expression of CCL2 mRNA CTD PMID:33533595 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Thiamethoxam results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein] CTD PMID:16981889 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO Thiamethoxam results in increased expression of CXCL5 mRNA CTD PMID:33533595 NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
decreases expression
EXP Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP11A1 mRNA] CTD PMID:34181816 NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression
multiple interactions
EXP Thiamethoxam results in decreased expression of CYP17A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of CYP17A1 mRNA]
CTD PMID:34181816 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression
multiple interactions
increases activity
ISO
EXP
thiamethoxam results in increased expression of CYP19A1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of CYP19A1 mRNA]
thiamethoxam results in increased activity of CYP19A1 protein
CTD PMID:26464060 PMID:28750898 PMID:34181816 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases expression ISO Thiamethoxam results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam CTD PMID:16153789 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Thiamethoxam results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Thiamethoxam results in increased expression of DDIT3 mRNA; Thiamethoxam results in increased expression of DDIT3 protein CTD PMID:33533595 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Esr1 estrogen receptor 1 affects binding
decreases expression
ISO Thiamethoxam binds to ESR1 protein
Thiamethoxam results in decreased expression of ESR1 protein
CTD PMID:31550567 PMID:33533595 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Foxo3 forkhead box O3 increases expression ISO Thiamethoxam results in increased expression of FOXO3 mRNA CTD PMID:33533595 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Fshr follicle stimulating hormone receptor decreases expression ISO Thiamethoxam results in decreased expression of FSHR protein CTD PMID:33533595 NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Thiamethoxam results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression ISO Thiamethoxam results in decreased expression of GADD45B mRNA CTD PMID:33533595 NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases activity
multiple interactions
EXP Thiamethoxam results in increased activity of GOT1 protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GOT1 protein]
CTD PMID:30621503 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity EXP thiamethoxam results in decreased activity of GPT protein CTD PMID:29197058 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
decreases expression
decreases activity
multiple interactions
ISO
EXP
Thiamethoxam results in increased expression of GPX1 mRNA
Thiamethoxam results in decreased expression of GPX1 mRNA
Thiamethoxam results in decreased activity of GPX1 protein
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of GPX1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of GPX1 mRNA]
CTD PMID:30621503 PMID:33533595 PMID:36958429 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression
multiple interactions
EXP Thiamethoxam results in decreased expression of HSD3B1 mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of HSD3B1 mRNA]
CTD PMID:34181816 NCBI chr 2:188,858,574...188,864,694
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Thiamethoxam results in increased expression of HSPA5 mRNA; Thiamethoxam results in increased expression of HSPA5 protein CTD PMID:33533595 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL1B protein]
Thiamethoxam results in increased expression of IL1B mRNA; Thiamethoxam results in increased expression of IL1B protein
CTD PMID:36958429 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP Silymarin inhibits the reaction [Thiamethoxam results in increased expression of IL6 mRNA] CTD PMID:36958429 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression ISO Thiamethoxam results in decreased expression of ITPR1 mRNA CTD PMID:33533595 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Thiamethoxam results in decreased expression of JUNB mRNA CTD PMID:33533595 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases activity
EXP [fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of LDHA protein]
Thiamethoxam results in increased activity of LDHA protein
CTD PMID:30621503 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression
increases expression
multiple interactions
ISO
EXP
Thiamethoxam results in decreased expression of LHCGR protein
Thiamethoxam results in increased expression of LHCGR mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in increased expression of LHCGR mRNA]
CTD PMID:33533595 PMID:34181816 NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Lst1 leukocyte specific transcript 1 increases expression ISO Thiamethoxam results in increased expression of LST1 mRNA CTD PMID:33533595 NCBI chr20:3,639,353...3,644,399
Ensembl chr20:3,634,749...3,637,997
JBrowse link
G Mc4r melanocortin 4 receptor decreases expression ISO Thiamethoxam results in decreased expression of MC4R mRNA CTD PMID:33533595 NCBI chr18:62,689,798...62,691,685
Ensembl chr18:60,419,832...60,421,719
JBrowse link
G Mmp7 matrix metallopeptidase 7 increases expression ISO Thiamethoxam results in increased expression of MMP7 mRNA CTD PMID:33533595 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
decreases activity
ISO
EXP
[thiamethoxam metabolite results in decreased activity of NOS2 protein] which results in increased chemical synthesis of Formaldehyde
Thiamethoxam results in increased expression of NOS2 mRNA
Silymarin inhibits the reaction [Thiamethoxam results in increased expression of NOS2 mRNA]
CTD PMID:29197058 PMID:36958429 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Plcg2 phospholipase C, gamma 2 decreases expression ISO Thiamethoxam results in decreased expression of PLCG2 mRNA CTD PMID:33533595 NCBI chr19:62,456,196...62,592,684
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Prnp prion protein increases expression ISO Thiamethoxam results in increased expression of PRNP mRNA CTD PMID:33533595 NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Thiamethoxam results in decreased expression of PTGS2 mRNA CTD PMID:33533595 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pthlh parathyroid hormone-like hormone decreases expression ISO Thiamethoxam results in decreased expression of PTHLH mRNA CTD PMID:33533595 NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Ptx3 pentraxin 3 increases expression ISO Thiamethoxam results in increased expression of PTX3 mRNA CTD PMID:33533595 NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:150,487,513...150,493,323
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
decreases expression
EXP Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of SCARB1 mRNA] CTD PMID:34181816 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Sesn2 sestrin 2 increases expression ISO Thiamethoxam results in increased expression of SESN2 mRNA CTD PMID:33533595 NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO Thiamethoxam results in decreased activity of SLC22A2 protein CTD PMID:31364238 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Thiamethoxam results in increased expression of SLC7A11 mRNA CTD PMID:33533595 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Sod1 superoxide dismutase 1 decreases activity
decreases expression
multiple interactions
EXP Thiamethoxam results in decreased activity of SOD1 protein
Thiamethoxam results in decreased expression of SOD1 mRNA
[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of SOD1 protein]; Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of SOD1 mRNA]
CTD PMID:30621503 PMID:36958429 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
multiple interactions
EXP Thiamethoxam results in decreased expression of STAR mRNA
Plant Extracts inhibits the reaction [Thiamethoxam results in decreased expression of STAR mRNA]
CTD PMID:34181816 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Thiamethoxam results in increased expression of STC2 mRNA CTD PMID:33533595 NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Thbs4 thrombospondin 4 decreases expression ISO Thiamethoxam results in decreased expression of THBS4 mRNA CTD PMID:33533595 NCBI chr 2:25,718,219...25,760,345
Ensembl chr 2:23,983,158...24,026,313
JBrowse link
G Thra thyroid hormone receptor alpha affects binding ISO Thiamethoxam binds to THRA protein CTD PMID:31550567 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Thiamethoxam results in increased expression of TNF protein]
Thiamethoxam results in increased expression of TNF mRNA; Thiamethoxam results in increased expression of TNF protein
CTD PMID:36958429 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnnt2 troponin T2, cardiac type increases secretion
multiple interactions
EXP Thiamethoxam results in increased secretion of TNNT2 protein
fenugreek seed meal inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]; Polysaccharides inhibits the reaction [Thiamethoxam results in increased secretion of TNNT2 protein]
CTD PMID:30520268 NCBI chr13:49,819,123...49,837,125
Ensembl chr13:47,267,204...47,285,388
JBrowse link
tilorone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Tilorone results in decreased activity of ACHE protein CTD PMID:33400519 PMID:33844597 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
JBrowse link
tropisetron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein] CTD PMID:38513929 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of BAX protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of BAX protein] CTD PMID:38513929 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 protein] CTD PMID:38513929 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp12 caspase 12 multiple interactions EXP Tropisetron inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP12 protein] CTD PMID:26286524 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
ISO
EXP
Tropisetron results in increased expression of CASP3 protein modified form
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of CASP3 protein]]; methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of CASP3 protein]; Tropisetron inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein]; Tropisetron inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]
Paclitaxel inhibits the reaction [Tropisetron results in increased expression of CASP3 protein modified form]
CTD PMID:26286524 PMID:34654991 PMID:36504472 PMID:38513929 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP Tropisetron inhibits the reaction [Hydrogen Peroxide results in increased activity of CAT protein] CTD PMID:26286524 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CCL3 protein] CTD PMID:23285267 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Cst3 cystatin C multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of CST3 protein] CTD PMID:33387473 NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:136,336,920...136,340,822
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL1 protein] CTD PMID:23285267 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of CXCL2 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of CXCL2 protein] CTD PMID:23285267 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP tropisetron results in increased expression of HMOX1 protein
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased activity of HMOX1 protein]]; SB 203580 inhibits the reaction [Tropisetron results in increased expression of HMOX1 protein]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased activity of HMOX1 protein]; Tropisetron inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]
CTD PMID:23285267 PMID:26286524 PMID:38513929 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein]; SB 203580 inhibits the reaction [tropisetron results in decreased expression of ICAM1 protein] CTD PMID:23285267 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of IL1B protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of IL1B protein]; Tropisetron inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
CTD PMID:24374478 PMID:36504472 PMID:38513929 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions EXP tropisetron inhibits the reaction [Vincristine results in increased expression of IL2 protein] CTD PMID:24374478 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
EXP chromium mesoporphyrin inhibits the reaction [Tropisetron results in decreased expression of IL6 protein]; SB 203580 inhibits the reaction [Tropisetron results in decreased expression of IL6 protein]
tropisetron results in decreased expression of IL6 protein
CTD PMID:23285267 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of IRAK1 protein] CTD PMID:36504472 NCBI chr  X:156,919,927...156,929,825
Ensembl chr  X:151,768,777...151,778,521
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of JAK2 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of JAK2 protein] CTD PMID:38513929 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Mir146a microRNA 146a multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of MIR146A mRNA] CTD PMID:36504472 NCBI chr10:28,349,996...28,350,090
Ensembl chr10:27,848,516...27,848,610
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in decreased expression of MMP2 mRNA] CTD PMID:33387473 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in decreased expression of MMP9 mRNA] CTD PMID:33387473 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
EXP
ISO
chromium mesoporphyrin inhibits the reaction [tropisetron results in decreased activity of MPO protein]; SB 203580 inhibits the reaction [tropisetron results in decreased activity of MPO protein]
tropisetron inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein]
CTD PMID:23285267 PMID:25837923 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of NFE2L2 protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in decreased expression of NFE2L2 protein]; Tropisetron inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 protein] CTD PMID:26286524 PMID:38513929 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
[Paclitaxel co-treated with Tropisetron] results in decreased expression of RELA protein
methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of RELA protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased phosphorylation of RELA protein]; Tropisetron inhibits the reaction [Streptozocin results in increased expression of RELA protein]
CTD PMID:34654991 PMID:36504472 PMID:38513929 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO tropisetron inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA] CTD PMID:33387473 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of TLR4 protein] CTD PMID:36504472 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
chromium mesoporphyrin inhibits the reaction [Tropisetron results in decreased expression of TNF protein]; methyllycaconitine inhibits the reaction [Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of TNF protein]]; Tropisetron inhibits the reaction [3-nitropropionic acid results in increased expression of TNF protein]; Tropisetron inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Tropisetron inhibits the reaction [Vincristine results in increased expression of TNF protein]
tropisetron inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
tropisetron results in decreased expression of TNF protein
CTD PMID:23285267 PMID:24374478 PMID:36504472 PMID:38513929 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of TP53 protein] CTD PMID:33387473 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions EXP Tropisetron inhibits the reaction [Streptozocin results in increased expression of TRAF6 protein] CTD PMID:36504472 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
varenicline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E affects response to substance ISO APOE protein affects the susceptibility to Varenicline CTD PMID:28202387 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression
ISO methyllycaconitine inhibits the reaction [Varenicline results in increased expression of CD36 mRNA]; methyllycaconitine inhibits the reaction [Varenicline results in increased expression of CD36 protein]
Varenicline results in increased expression of CD36 mRNA; Varenicline results in increased expression of CD36 protein
CTD PMID:28202387 NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cdh5 cadherin 5 decreases expression
multiple interactions
ISO Varenicline results in decreased expression of CDH5
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Varenicline results in decreased expression of CDH5]; methyllycaconitine inhibits the reaction [Varenicline results in decreased expression of CDH5]; pyrazolanthrone inhibits the reaction [Varenicline results in decreased expression of CDH5]; SB 203580 inhibits the reaction [Varenicline results in decreased expression of CDH5]
CTD PMID:28842382 NCBI chr19:821,875...860,931
Ensembl chr19:815,411...854,368
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Varenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Varenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:16766716 NCBI chr 8:64,297,755...64,311,251
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO
EXP
Varenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
Varenicline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
varenicline binds to Chrna4 protein; varenicline inhibits [alpha-conotoxin MII binds to Chrna4 protein] in rat brain striatal sections
CTD
RGD
PMID:16766716 PMID:20100906 PMID:20207347 PMID:20331614 PMID:20373480 More... RGD:8549526 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit multiple interactions
affects binding
EXP Varenicline binds to and results in increased activity of CHRNA6 protein
Varenicline binds to Chrna6 protein
Varenicline inhibits the reaction [alpha-Conotoxin MII binds to Chrna6]; Varenicline inhibits the reaction [epibatidine binds to Chrna6].
CTD
RGD
PMID:16766716 PMID:22550286 PMID:22550286 RGD:8549526, RGD:8549526 NCBI chr16:71,400,615...71,407,315
Ensembl chr16:64,697,741...64,704,441
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP Varenicline binds to and results in increased activity of [CHRNA7 protein binds to CHRNA7 protein] CTD PMID:16766716 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO
EXP
Varenicline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Varenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
Varenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]; Varenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:16766716 PMID:20100906 PMID:20207347 PMID:20331614 PMID:20373480 More... NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP Varenicline binds to and results in increased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:16766716 NCBI chr 8:64,312,644...64,333,319
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Varenicline results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Varenicline results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
decreases activity
ISO Varenicline results in increased phosphorylation of MAPK1 protein
methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of MAPK1 protein]
Varenicline results in decreased activity of MAPK1 protein
CTD PMID:28202387 PMID:28842382 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
decreases activity
ISO Varenicline results in increased phosphorylation of MAPK3 protein
methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of MAPK3 protein]
Varenicline results in decreased activity of MAPK3 protein
CTD PMID:28202387 PMID:28842382 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression
multiple interactions
ISO Varenicline results in increased expression of OLR1 mRNA; Varenicline results in increased expression of OLR1 protein
methyllycaconitine inhibits the reaction [Varenicline results in increased expression of OLR1 mRNA]; methyllycaconitine inhibits the reaction [Varenicline results in increased expression of OLR1 protein]
CTD PMID:28202387 NCBI chr 4:164,612,460...164,635,082
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Varenicline results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions
ISO Varenicline results in increased phosphorylation of RELA protein
methyllycaconitine inhibits the reaction [Varenicline results in increased phosphorylation of RELA protein]
CTD PMID:28202387 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc22a2 solute carrier family 22 member 2 affects response to substance ISO SLC22A2 gene SNP affects the susceptibility to Varenicline CTD PMID:25143296 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        pharmacological role 19088
          neurotransmitter agent 16802
            cholinergic drug 5368
              cholinergic agonist 2010
                nicotinic acetylcholine receptor agonist 1938
                  (-)-lobeline 7
                  (S)-nicotine + 1158
                  (S)-nornicotine 0
                  1,1-dimethyl-4-phenylpiperazinium iodide 7
                  3-hydroxy imidacloprid 0
                  anabasine + 4
                  carbachol 60
                  clothianidin + 403
                  cytisine 10
                  decamethonium 3
                  flupyradifurone 2
                  imidacloprid + 442
                  neonicotinoid insectide + 910
                  nicotine + 1158
                  nicotine sulfate 0
                  sulfoxaflor 18
                  thiocyclam 0
                  thiocyclam hydrochloride 0
                  thiocyclam oxalate 0
                  tilorone 1
                  tilorone dihydrochloride 0
                  tropisetron 29
                  tropisetron hydrochloride 0
                  varenicline 17
                  varenicline tartrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      application 19697
        pharmaceutical 19534
          drug 19534
            neurotransmitter agent 16802
              cholinergic drug 5368
                cholinergic agonist 2010
                  nicotinic acetylcholine receptor agonist 1938
                    (-)-lobeline 7
                    (S)-nicotine + 1158
                    (S)-nornicotine 0
                    1,1-dimethyl-4-phenylpiperazinium iodide 7
                    3-hydroxy imidacloprid 0
                    anabasine + 4
                    carbachol 60
                    clothianidin + 403
                    cytisine 10
                    decamethonium 3
                    flupyradifurone 2
                    imidacloprid + 442
                    neonicotinoid insectide + 910
                    nicotine + 1158
                    nicotine sulfate 0
                    sulfoxaflor 18
                    thiocyclam 0
                    thiocyclam hydrochloride 0
                    thiocyclam oxalate 0
                    tilorone 1
                    tilorone dihydrochloride 0
                    tropisetron 29
                    tropisetron hydrochloride 0
                    varenicline 17
                    varenicline tartrate 0
paths to the root