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Gene: Dnmt1 (DNA methyltransferase 1) Rattus norvegicus
Symbol: Dnmt1
Name: DNA methyltransferase 1
Description: Exhibits several functions, including DNA (cytosine-5-)-methyltransferase activity; estrogen receptor binding activity; and histone deacetylase binding activity. Involved in several processes, including DNA metabolic process; cellular response to growth factor stimulus; and nervous system development. Localizes to several cellular components, including cytoplasm; neuronal cell body; and nucleus. Used to study choline deficiency disease and lung carcinoma. Biomarker of choline deficiency disease; congenital heart disease; congestive heart failure; liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; and hereditary sensory neuropathy type 1E. Orthologous to human DNMT1 (DNA methyltransferase 1); PARTICIPATES IN DNA modification pathway; glycine N-methyltransferase deficiency pathway; homocystinuria pathway; INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile.
Type: protein-coding
Also known as: DNA (cytosine-5)-methyltransferase 1; DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase (cytosine-5) 1; DNA methyltransferase I; DNA MTase RnoIP; m.RnoIP; MCMT
Homo sapiens (human) : DNMT1 (DNA methyltransferase 1)  HGNC  Alliance
Mus musculus (house mouse) : Dnmt1 (DNA methyltransferase (cytosine-5) 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnmt1 (DNA methyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DNMT1 (DNA methyltransferase 1)
Canis lupus familiaris (dog) : DNMT1 (DNA methyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnmt1 (DNA methyltransferase 1)
Sus scrofa (pig) : DNMT1 (DNA methyltransferase 1)
Chlorocebus sabaeus (African green monkey) : DNMT1 (DNA methyltransferase 1)
Heterocephalus glaber (naked mole-rat) : Dnmt1 (DNA methyltransferase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0821,922,515 - 21,968,495 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,922,515 - 21,968,495 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0821,978,830 - 22,024,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4819,926,995 - 19,973,256 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1819,927,666 - 19,973,220 (-)NCBI
Celera820,835,612 - 20,881,380 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dnmt1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620979
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.