Dio3 (iodothyronine deiodinase 3) - Rat Genome Database

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Gene: Dio3 (iodothyronine deiodinase 3) Rattus norvegicus
Symbol: Dio3
Name: iodothyronine deiodinase 3
RGD ID: 68420
Description: Predicted to enable thyroxine 5'-deiodinase activity and thyroxine 5-deiodinase activity. Involved in brown fat cell proliferation and response to hypoxia. Predicted to be located in intracellular membrane-bounded organelle. Biomarker of congestive heart failure. Orthologous to human DIO3 (iodothyronine deiodinase 3); INTERACTS WITH (+)-schisandrin B; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 5DIII; deiodinase iodothyronine type 3; deiodinase iodothyronine type III; deiodinase, iodothyronine, type 3; deiodinase, iodothyronine, type III; DIOIII; thyroxine 5-deiodinase; type 3 DI; type III iodothyronine deiodinase; type-III 5'-deiodinase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Thshl1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.26129,285,747 - 129,287,608 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6129,285,749 - 129,286,660 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6129,464,249 - 129,466,110 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.06129,760,113 - 129,761,974 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.06129,123,269 - 129,125,130 (+)NCBIRnor_WKY
Rnor_6.06134,627,278 - 134,629,139 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6134,627,278 - 134,629,138 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06143,766,523 - 143,768,383 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,858,528 - 126,860,389 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
2-Ethylhexyl acrylate  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,5-dichloro-2-n-octyl-3(2H)-isothiazolone  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
actinomycin D  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (ISO)
ammonium chloride  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
C60 fullerene  (EXP)
captafol  (ISO)
chlordecone  (ISO)
chlorothalonil  (ISO)
choline  (ISO)
cisplatin  (EXP)
clothianidin  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cycloheximide  (EXP)
Cyclopamine  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
Didecyldimethylammonium  (ISO)
diethyl hydrogen phosphate  (EXP)
dinocap  (ISO)
disodium selenite  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
fenvalerate  (EXP)
fipronil  (EXP,ISO)
flavonoids  (EXP)
fluazinam  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
furan  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (EXP)
L-methionine  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
linoleic acid  (ISO)
lipopolysaccharide  (EXP)
lithocholic acid  (ISO)
masoprocol  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methyltrioctylammonium chloride  (ISO)
morin  (ISO)
N-acetyl-L-cysteine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
octhilinone  (ISO)
ozone  (ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalaldehyde  (ISO)
pioglitazone  (ISO)
potassium bromate  (ISO)
pravastatin  (EXP,ISO)
propiconazole  (EXP)
quinoxyfen  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
streptozocin  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thyroxine  (EXP)
titanium dioxide  (EXP)
triadimefon  (EXP)
triflumizole  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
xanthohumol  (ISO)
zoxamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Cloning and expression of a cDNA for a mammalian type III iodothyronine deiodinase. Croteau W, etal., J Biol Chem 1995 Jul 14;270(28):16569-75.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Gene expression from the imprinted Dio3 locus is associated with cell proliferation of cultured brown adipocytes. Hernandez A, etal., Endocrinology. 2007 Aug;148(8):3968-76. Epub 2007 May 17.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats. Simonides WS, etal., J Clin Invest. 2008 Mar;118(3):975-83.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12399446   PMID:12586753   PMID:12959985   PMID:16410833   PMID:17628010   PMID:18566113   PMID:18787028   PMID:19916870   PMID:20203194   PMID:21429942   PMID:22723689   PMID:23586759  
PMID:25002520   PMID:33746903  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.26129,285,747 - 129,287,608 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6129,285,749 - 129,286,660 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6129,464,249 - 129,466,110 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.06129,760,113 - 129,761,974 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.06129,123,269 - 129,125,130 (+)NCBIRnor_WKY
Rnor_6.06134,627,278 - 134,629,139 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6134,627,278 - 134,629,138 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06143,766,523 - 143,768,383 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,858,528 - 126,860,389 (+)NCBICelera
Cytogenetic Map6q32NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3814101,561,351 - 101,563,452 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl14101,560,139 - 101,563,452 (+)EnsemblGRCh38hg38GRCh38
GRCh3714102,027,688 - 102,029,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614101,097,441 - 101,099,542 (+)NCBINCBI36Build 36hg18NCBI36
Build 3414101,097,440 - 101,099,540NCBI
Celera1482,082,777 - 82,084,878 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1482,210,257 - 82,212,139 (+)NCBIHuRef
CHM1_114101,966,169 - 101,968,270 (+)NCBICHM1_1
T2T-CHM13v2.01495,796,605 - 95,798,706 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3912110,245,664 - 110,247,531 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12110,245,502 - 110,247,531 (+)EnsemblGRCm39 Ensembl
GRCm3812110,279,230 - 110,281,097 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12110,279,068 - 110,281,097 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712111,517,440 - 111,519,307 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612110,727,040 - 110,728,902 (+)NCBIMGSCv36mm8
Celera12111,469,979 - 111,471,846 (+)NCBICelera
Cytogenetic Map12F1NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_0049555381,042,949 - 1,045,038 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.114101,496,027 - 101,497,958 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01482,188,126 - 82,190,220 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1869,696,779 - 69,698,880 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha869,212,787 - 69,214,888 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0869,976,717 - 69,978,827 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1869,640,338 - 69,642,442 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0869,705,306 - 69,707,410 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0870,104,995 - 70,107,102 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244086404,838,557 - 4,840,570 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366045,241,877 - 5,243,910 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa10.27130,202,342 - 130,204,449 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12479,538,264 - 79,544,448 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605366,683,231 - 66,685,324 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247342,611,864 - 2,613,932 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Dio3
2 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26129,286,330 - 129,287,557 (+)MAPPERmRatBN7.2
Rnor_6.06134,627,862 - 134,629,088NCBIRnor6.0
Rnor_5.06143,767,107 - 143,768,333UniSTSRnor5.0
Celera6126,859,112 - 126,860,338UniSTS
RH 3.4 Map6785.19UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26129,285,776 - 129,287,221 (+)MAPPERmRatBN7.2
Rnor_6.06134,627,308 - 134,628,752NCBIRnor6.0
Rnor_5.06143,766,553 - 143,767,997UniSTSRnor5.0
Celera6126,858,558 - 126,860,002UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26129,286,009 - 129,286,137 (+)MAPPERmRatBN7.2
Rnor_6.06134,627,541 - 134,627,668NCBIRnor6.0
Rnor_5.06143,766,786 - 143,766,913UniSTSRnor5.0
Celera6126,858,791 - 126,858,918UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2
Low 1 10 9 9 57 2 28 1
Below cutoff 2 22 31 17 9 17 5 8 17 28 9 8 5


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078113
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6129,285,749 - 129,286,660 (+)Ensembl
Rnor_6.0 Ensembl6134,627,278 - 134,629,138 (+)Ensembl
RefSeq Acc Id: NM_017210   ⟹   NP_058906
RefSeq Status: REVIEWED
Rat AssemblyChrPosition (strand)Source
mRatBN7.26129,285,747 - 129,287,608 (+)NCBI
Rnor_6.06134,627,278 - 134,629,139 (+)NCBI
Rnor_5.06143,766,523 - 143,768,383 (+)NCBI
Celera6126,858,528 - 126,860,389 (+)NCBI
Protein Sequences
Protein RefSeqs NP_058906 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52241 (Get FASTA)   NCBI Sequence Viewer  
  EDL97515 (Get FASTA)   NCBI Sequence Viewer  
  P49897 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058906   ⟸   NM_017210
- UniProtKB: P49897 (UniProtKB/Swiss-Prot)
- Sequence:


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68420 AgrOrtholog
BioCyc Gene G2FUF-35897 BioCyc
BioCyc Pathway PWY-6260 [thyroid hormone metabolism I (via deiodination)] BioCyc
  PWY-6261 [thyroid hormone metabolism II (via conjugation and/or degradation)] BioCyc
Ensembl Genes ENSRNOG00000052017 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000093110 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000078113 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Iodothyronine_deiodinase UniProtKB/Swiss-Prot
  Iodothyronine_deiodinase_AS UniProtKB/Swiss-Prot
  Iodothyronine_deiodinase_I/III UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:29475 UniProtKB/Swiss-Prot
PANTHER PTHR11781 UniProtKB/Swiss-Prot
Pfam T4_deiodinase UniProtKB/Swiss-Prot
PhenoGen Dio3 PhenoGen
PIRSF IOD UniProtKB/Swiss-Prot
  IODI_III UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
TIGR TC238557
UniProt IOD3_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-26 Dio3  iodothyronine deiodinase 3  Dio3  deiodinase, iodothyronine, type III  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Dio3  deiodinase, iodothyronine, type III    deiodinase, iodothyronine, type 3  Name updated 629478 APPROVED
2002-06-10 Dio3  deiodinase, iodothyronine, type 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in placenta and several fetal tissues during embryonic development 68236
gene_function catalyzes the inner ring deiodination of the prohormone thyroxine (T4) and of the bioactive hormone 3,3',5-triiodothyronine (T3) to 3,3'-T2 inactive metabolites 68236
gene_homology cDNA displays significant homology with amphibian (Xenopus laevis) 68236