Dio3 (iodothyronine deiodinase 3)

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Gene: Dio3 (iodothyronine deiodinase 3) Rattus norvegicus

Analyze

Symbol:

Dio3

Name:

iodothyronine deiodinase 3

RGD ID:

68420

Description:

Predicted to have thyroxine 5'-deiodinase activity and thyroxine 5-deiodinase activity. Involved in brown fat cell proliferation and response to hypoxia. Predicted to localize to intracellular membrane-bounded organelle. Biomarker of congestive heart failure. Orthologous to human DIO3 (iodothyronine deiodinase 3); INTERACTS WITH (+)-schisandrin B; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

5DIII; deiodinase iodothyronine type 3; deiodinase iodothyronine type III; deiodinase, iodothyronine, type 3; deiodinase, iodothyronine, type III; DIOIII; thyroxine 5-deiodinase; type 3 DI; type III iodothyronine deiodinase; type-III 5'-deiodinase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	129,285,747 - 129,287,608 (+)	NCBI
Rnor_6.0 Ensembl	6	134,627,278 - 134,629,138 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	6	134,627,278 - 134,629,139 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	6	143,766,523 - 143,768,383 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	6	126,858,528 - 126,860,389 (+)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Breast Neoplasms (ISO)

congestive heart failure (IEP)

Neoplasm Metastasis (ISO)

thyroid gland papillary carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(+)-schisandrin B (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dinitrotoluene (EXP)

2-Ethylhexyl acrylate (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,3',5-triiodo-L-thyronine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,5-dichloro-2-n-octyl-3(2H)-isothiazolone (ISO)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (ISO)

8-Br-cAMP (EXP)

9-cis-retinoic acid (ISO)

acetamide (EXP)

actinomycin D (EXP)

all-trans-retinoic acid (EXP,ISO)

alpha-hexylcinnamaldehyde (ISO)

alpha-linolenic acid (ISO)

ammonium chloride (EXP)

benzalkonium chloride (ISO)

benzo[a]pyrene (EXP,ISO)

bicalutamide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol A diglycidyl ether (ISO)

C60 fullerene (EXP)

captafol (ISO)

chlordecone (ISO)

chlorothalonil (ISO)

choline (ISO)

cisplatin (EXP)

clothianidin (ISO)

colforsin daropate hydrochloride (EXP)

copper atom (EXP)

copper(0) (EXP)

cycloheximide (EXP)

Cyclopamine (ISO)

dexamethasone (ISO)

diethyl hydrogen phosphate (EXP)

dinocap (ISO)

disodium selenite (EXP)

dorsomorphin (ISO)

entinostat (ISO)

fenvalerate (EXP)

fipronil (EXP,ISO)

flavonoids (EXP)

fluazinam (ISO)

fluoxetine (EXP)

folic acid (ISO)

furan (EXP)

glyphosate (EXP)

hydrogen peroxide (EXP)

L-methionine (ISO)

linoleic acid (ISO)

lipopolysaccharide (EXP)

lithocholic acid (ISO)

masoprocol (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

methyltrioctylammonium chloride (ISO)

morin (ISO)

N-acetyl-L-cysteine (EXP)

N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine (EXP)

naphthalene (ISO)

octhilinone (ISO)

ozone (ISO)

pentachlorophenol (EXP)

perfluorooctane-1-sulfonic acid (EXP)

perfluorooctanoic acid (EXP)

phenobarbital (EXP)

phorbol 13-acetate 12-myristate (EXP,ISO)

phthalaldehyde (ISO)

pioglitazone (ISO)

potassium bromate (ISO)

pravastatin (EXP,ISO)

propiconazole (EXP)

quinoxyfen (ISO)

ranitidine (EXP)

S-butyl-DL-homocysteine (S,R)-sulfoximine (EXP)

SB 203580 (EXP,ISO)

SB 431542 (ISO)

Tetrachlorobisphenol A (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

thyroxine (EXP)

titanium dioxide (EXP)

triadimefon (EXP)

triflumizole (ISO)

triptonide (ISO)

valproic acid (ISO)

vemurafenib (ISO)

xanthohumol (ISO)

zoxamide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (ISO)

brown fat cell proliferation (IEP)

hormone biosynthetic process (IEA)

positive regulation of multicellular organism growth (ISO)

response to hypoxia (IEP)

retinal cone cell apoptotic process (ISO)

retinal cone cell development (ISO)

thyroid hormone catabolic process (ISO)

thyroid hormone metabolic process (IBA,ISO,TAS)

Cellular Component

cellular_component (ND)

endosome membrane (IEA)

integral component of membrane (IEA)

intracellular membrane-bounded organelle (ISO)

plasma membrane (IEA)

Molecular Function

thyroxine 5'-deiodinase activity (IBA,ISO,TAS)

thyroxine 5-deiodinase activity (ISO)

References

References - curated


1.	Croteau W, etal., J Biol Chem 1995 Jul 14;270(28):16569-75.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA data from the GO Consortium
4.	Hernandez A, etal., Endocrinology. 2007 Aug;148(8):3968-76. Epub 2007 May 17.
5.	MGD data from the GO Consortium
6.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	RGD automated data pipeline
8.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	RGD automated import pipeline for gene-chemical interactions
10.	RGD comprehensive gene curation
11.	Simonides WS, etal., J Clin Invest. 2008 Mar;118(3):975-83.
12.	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:12399446	PMID:12586753	PMID:12959985	PMID:16410833	PMID:17628010	PMID:18566113	PMID:18787028	PMID:19916870	PMID:20203194	PMID:21429942	PMID:22723689	PMID:23586759
PMID:25002520

Genomics

Candidate Gene Status

Dio3 is a candidate Gene for QTL Thshl1

Comparative Map Data

Dio3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	129,285,747 - 129,287,608 (+)	NCBI
Rnor_6.0 Ensembl	6	134,627,278 - 134,629,138 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	6	134,627,278 - 134,629,139 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	6	143,766,523 - 143,768,383 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	6	126,858,528 - 126,860,389 (+)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

DIO3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	14	101,561,351 - 101,563,452 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	14	101,561,351 - 101,563,452 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	14	102,027,688 - 102,029,789 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	101,097,441 - 101,099,542 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	14	101,097,440 - 101,099,540	NCBI
Celera	14	82,082,777 - 82,084,878 (+)	NCBI
Cytogenetic Map	14	q32.31	NCBI
HuRef	14	82,210,257 - 82,212,139 (+)	NCBI		HuRef
CHM1_1	14	101,966,169 - 101,968,270 (+)	NCBI		CHM1_1

Dio3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	110,245,664 - 110,247,531 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	12	110,245,502 - 110,247,531 (+)	Ensembl
GRCm38	12	110,279,230 - 110,281,097 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	110,279,068 - 110,281,097 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	111,517,440 - 111,519,307 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	12	110,727,040 - 110,728,902 (+)	NCBI			mm8
Celera	12	111,469,979 - 111,471,846 (+)	NCBI		Celera
Cytogenetic Map	12	F1	NCBI

Dio3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955538	1,042,949 - 1,045,038 (+)	NCBI	ChiLan1.0	ChiLan1.0

DIO3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	14	101,496,027 - 101,497,958 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	14	82,188,126 - 82,190,220 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

DIO3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	69,696,779 - 69,698,880 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	69,212,787 - 69,214,888 (+)	NCBI
ROS_Cfam_1.0	8	69,976,717 - 69,978,827 (+)	NCBI
UMICH_Zoey_3.1	8	69,640,338 - 69,642,442 (+)	NCBI
UNSW_CanFamBas_1.0	8	69,705,306 - 69,707,410 (+)	NCBI
UU_Cfam_GSD_1.0	8	70,104,995 - 70,107,102 (+)	NCBI

Dio3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	4,838,557 - 4,840,570 (-)	NCBI
SpeTri2.0	NW_004936604	5,241,877 - 5,243,910 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DIO3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa10.2	7	130,202,342 - 130,204,449 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DIO3
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	79,538,264 - 79,544,448 (+)	NCBI

Dio3
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624734	2,611,864 - 2,613,932 (-)	NCBI

Position Markers

RH128338

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	6	134,627,862 - 134,629,088	NCBI	Rnor6.0
Rnor_5.0	6	143,767,107 - 143,768,333	UniSTS	Rnor5.0
Celera	6	126,859,112 - 126,860,338	UniSTS
RH 3.4 Map	6	785.19	UniSTS

UniSTS:489530

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	6	134,627,308 - 134,628,752	NCBI	Rnor6.0
Rnor_5.0	6	143,766,553 - 143,767,997	UniSTS	Rnor5.0
Celera	6	126,858,558 - 126,860,002	UniSTS

UniSTS:532166

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	6	134,627,541 - 134,627,668	NCBI	Rnor6.0
Rnor_5.0	6	143,766,786 - 143,766,913	UniSTS	Rnor5.0
Celera	6	126,858,791 - 126,858,918	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731173	Uae22	Urinary albumin excretion QTL 22	10.1		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	68781170	147991367	Rat
2290393	Uae37	Urinary albumin excretion QTL 37		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	68781170	147991367	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	75623277	136143011	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	75623277	136426962	Rat
1581550	Pur8	Proteinuria QTL 8			total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	75623393	136142742	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	75623393	136142742	Rat
724513	Uae14	Urinary albumin excretion QTL 14	6.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	88996335	139410483	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	89631358	134631358	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	89631358	134631358	Rat
1300076	Glom8	Glomerulus QTL 8	7	0.000000009	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	6	91703409	136703409	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (VE) (CMO:0000132)	6	92879510	137879510	Rat
12801411	Schws8	Schwannoma susceptibility QTL 8			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	99273921	144273921	Rat
61414	Pia3	Pristane induced arthritis QTL 3	4.5		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	6	99273921	144792678	Rat
8552796	Vie3	Viral induced encephalitis QTL 3	2.6		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	6	101207574	147991367	Rat
1358355	Srcrt4	Stress Responsive Cort QTL 4	6.39		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	104363890	147991367	Rat
2313399	Anxrr28	Anxiety related response QTL 28			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	6	104381930	138066274	Rat
4145118	Mcs26	Mammary carcinoma susceptibility QTL 26		0.0001	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	111134524	138065254	Rat
737976	Pia24	Pristane induced arthritis QTL 24			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	6	117355600	147991367	Rat
1298087	Iddm18	Insulin dependent diabetes mellitus QTL 18		0.0001	urine glucose amount (VT:0001758)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	6	121224054	135658578	Rat
1641917	Colcr5	Colorectal carcinoma resistance QTL 5	3.18	0.0009	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	6	127286494	144745573	Rat
2293085	Iddm29	Insulin dependent diabetes mellitus QTL 29	7.66		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	6	127286494	147249902	Rat
61329	Eae9	Experimental allergic encephalomyelitis QTL 9	3.7		body mass (VT:0001259)	change in body weight (CMO:0002045)	6	127286494	147991367	Rat
2312560	Pur20	Proteinuria QTL 20	2.1	0.005	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	130561943	144745573	Rat
71111	Iddm8	Insulin dependent diabetes mellitus QTL 8	1.9	0.002	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	6	132652096	138068606	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium											2
Low	1		10	9		9			57	2	28	1
Below cutoff	2	22	31	17	9	17	5	8	17	28	9	8	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017210	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BM414881	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000169	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U24282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000078113

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	134,627,278 - 134,629,138 (+)	Ensembl

RefSeq Acc Id:

NM_017210 ⟹ NP_058906

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	129,285,747 - 129,287,608 (+)	NCBI
Rnor_6.0	6	134,627,278 - 134,629,139 (+)	NCBI
Rnor_5.0	6	143,766,523 - 143,768,383 (+)	NCBI
Celera	6	126,858,528 - 126,860,389 (+)	NCBI

Sequence:

show sequence

AGATGCCTCGCCAGGCCGCCTCGAGGTTGGTGGTCGGAGAAGGTGAAGGGCCCCCGGGGGCTTC
GGGGCCCGCGGCCACCATGCTGCGCTCCCTGCTGCTTCACTCTCTGAGGCTCTGCGCCCAGACC
GCCTCGTGCCTCGTGCTGTTCCCGCGCTTCCTAGGCACGGCCTTCATGCTCTGGCTTTTAGATT
TCTTGTGCATCCGCAAGCATTTCCTGCGCCGTCGTCATCCTGACCACCCCGAGCCCGAAGTAGA
GCTCAACAGTGAAGGTGAGGAGATGCCCCCTGACGACCCACCCATCTGCGTATCCGACGACAAC
CGGCTGTGCACCCTGGCCTCTCTGAAGGCCGTGTGGCATGGCCAGAAGTTGGATTTCTTCAAGC
AGGCCCATGAGGGTGGCCCAGCACCTAACTCGGAGGTCGTCCGGCCTGATGGCTTCCAGAGCCA
GCGCATCCTCGACTACGCACAAGGGACCCGCCCGTTGGTGCTCAATTTTGGCAGCTGTACCTGA
CCACCGTTCATGGCGCGGATGAGCGCCTTCCAGCGCCTGGTCACCAAGTACCAGCGCGACGTTG
ACTTCCTTATCATCTACATCGAGGAAGCCCACCCATCCGATGGCTGGGTCACCACAGATTCACC
CTACGTCATCCCACAGCACCGCAGCTTGGAGGACCGTGTCAGCGCAGCAAGAGTACTTCAGCAA
GGCGCACCTGGCTGTGCTCTGGTTCTGGACACGATGGCCAACTCCAGCAGTTCCGCATATGGTG
CCTATTTTGAGCGCCTCTACGTCATCCAGAGCGGCACCATCATGTACCAGGGAGGCCGTGGCCC
CGACGGTTACCAGGTGTCTGAGTTGCGCACTTGGTTGGAGCGCTATGACGAGCAGTTGCATGGT
ACTAGGCCACGTCGACTCTAAAAAACCAAGGGACAAGTGACTGAATTGGTGGGCTGGGTCTTCT
GGGCCTTCGAAGCTCATGTGCGAATGCTCCAAAAGAAGTCAAGGTTTTCAGGGGTCCCGTGACA
CAGATGAGCACAGCCACAGAACTCAGGCTGAGTCTGGCTAACTTGAGACTCTGCTATAGTGACT
CCCTTTTGGTACTTTTTGGCTTGCTTTCTGGAGCATTGCTGTGGCTAGAACTGGCAACTTTGTC
CCTGCTGAAGTTTACCTGCTGGACTTTCTGACACCTGCTCCCCAGCGCTATTTCAGCAAAGCGC
AATAAGTCGCCAGCATCTCACAGCTCGGGACTTGTTGGCCACGCCCGCGCGCCCTGAGCGCAGC
TGGGTTCCAGCAGCGCCTCCGGCTCTAGCTAGTTGCCTGGCACCCACCTGTCGAGAGCAGGGAG
TCCTGCTGCTTTTGTGTTTATTTCTTATCCCTGGGTTGGGGGAGGGGCTCAAGATAAAGGGTGG
GCAGGGTAATTTCCCCGCCTAGCTTTAGGTGCGCTGGAACCCTGGCTGCTGATGACGAACCGCC
TCTAACTGGGCTTGACCACGGGTCGGCTCTGAATTGCAGAGGGGCTCGAAACAGCGCCTAAAGT
AAGAGGGGGAAAGTGCTCTGGGTTCCACGGGGAACCGTCAAAAACAGGGTGAAAGAGGGACATG
GTAAGGGGTGGGCTTCAGGACCAAAGGAAGCGGCTTGGGGCACTGGCGAGGTTCGCAGGTCCCC
AAGAGGGAGGCTAGGACTCCTTGGAGAAGGGATTAATTGGTTCGAAGACAAGGAGATGGGGAAG
AGCCTGGGAGTCCTAAGCAGAAAGAGCGGGTTGTGGGGTGGGGTGAAAACCAGTCAGTGAATGT
TGTGTTGGAAACGTTCCTTGTGTATAAACTTTTAAGTTACAATAATAAAGACTTGAAGGAAGTT
GCTCTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_058906	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC52241	(Get FASTA)	NCBI Sequence Viewer
	EDL97515	(Get FASTA)	NCBI Sequence Viewer
	P49897	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_058906 ⟸ NM_017210

- UniProtKB:

P49897 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MPRQAASRLVVGEGEGPPGASGPAATMLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDF
LCIRKHFLRRRHPDHPEPEVELNSEGEEMPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQ
AHEGGPAPNSEVVRPDGFQSQRILDYAQGTRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVD
FLIIYIEEAHPSDGWVTTDSPYVIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGA
YFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDEQLHGTRPRRL

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Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:68420	AgrOrtholog
Ensembl Genes	ENSRNOG00000052017	Ensembl
Gene3D-CATH	3.40.30.10	UniProtKB/Swiss-Prot
InterPro	Iodothyronine_deiodinase	UniProtKB/Swiss-Prot
	Iodothyronine_deiodinase_AS	UniProtKB/Swiss-Prot
	Iodothyronine_deiodinase_I/III	UniProtKB/Swiss-Prot
	Thioredoxin-like_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:29475	UniProtKB/Swiss-Prot
NCBI Gene	29475	ENTREZGENE
PANTHER	PTHR11781	UniProtKB/Swiss-Prot
Pfam	T4_deiodinase	UniProtKB/Swiss-Prot
PhenoGen	Dio3	PhenoGen
PIRSF	IOD	UniProtKB/Swiss-Prot
	IODI_III	UniProtKB/Swiss-Prot
PROSITE	T4_DEIODINASE	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52833	UniProtKB/Swiss-Prot
TIGR	TC238557
UniProt	IOD3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-10-26	Dio3	iodothyronine deiodinase 3	Dio3	deiodinase, iodothyronine, type III	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2003-04-09	Dio3	deiodinase, iodothyronine, type III		deiodinase, iodothyronine, type 3	Name updated	629478	APPROVED
2002-06-10	Dio3	deiodinase, iodothyronine, type 3			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA expressed in placenta and several fetal tissues during embryonic development	68236
gene_function	catalyzes the inner ring deiodination of the prohormone thyroxine (T4) and of the bioactive hormone 3,3',5-triiodothyronine (T3) to 3,3'-T2 inactive metabolites	68236
gene_homology	cDNA displays significant homology with amphibian (Xenopus laevis)	68236

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD