Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Dio3 (iodothyronine deiodinase 3) Rattus norvegicus
Symbol: Dio3
Name: iodothyronine deiodinase 3
Description: Predicted to have thyroxine 5'-deiodinase activity and thyroxine 5-deiodinase activity. Involved in brown fat cell proliferation and response to hypoxia. Predicted to localize to endosome membrane; integral component of membrane; and plasma membrane. Biomarker of congestive heart failure. Orthologous to human DIO3 (iodothyronine deiodinase 3); INTERACTS WITH (+)-schisandrin B; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5DIII; deiodinase iodothyronine type 3; deiodinase iodothyronine type III; deiodinase, iodothyronine, type 3; deiodinase, iodothyronine, type III; DIOIII; thyroxine 5-deiodinase; type 3 DI; type III iodothyronine deiodinase; type-III 5'-deiodinase
Homo sapiens (human) : DIO3 (iodothyronine deiodinase 3)  HGNC  Alliance
Mus musculus (house mouse) : Dio3 (deiodinase, iodothyronine type III)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dio3 (iodothyronine deiodinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DIO3 (iodothyronine deiodinase 3)
Canis lupus familiaris (dog) : DIO3 (iodothyronine deiodinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dio3 (iodothyronine deiodinase 3)
Sus scrofa (pig) : DIO3 (iodothyronine deiodinase 3)
Chlorocebus sabaeus (African green monkey) : DIO3 (iodothyronine deiodinase 3)
Heterocephalus glaber (naked mole-rat) : Dio3 (iodothyronine deiodinase 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.06134,627,278 - 134,629,139 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6134,627,278 - 134,629,138 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06143,766,523 - 143,768,383 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,858,528 - 126,860,389 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dio3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68420
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.