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The Hybrid Rat Diversity Panel

The Hybrid Rat Diversity Panel
The Hybrid Rat Diversity Panel (HRDP) is a panel of 96 inbred rat strains carefully chosen to maximize power to detect specific genetic loci associated with a complex trait and to maximize the genetic diversity among strains. The HRDP includes 33 genetically diverse inbred strains of rat and two panels of recombinant inbred rat strains, the FXLE/LEXF (33 strains) from Japan and the HXB/BXH (30 strains) from the Czech Republic. Recombinant inbred strains are panels of inbred strains derived from two inbred parental rat strains. The two parental strains are crossed to produce F1 pups. F1 pups are subsequently intercrossed to create an F2 generation. These genetically unique F2 generation rats are paired as founders and brother-sister mated for at least 20 generations to fix their genomes. The two RI panels used in the HRDP have been well characterized through studies focused on seizures, epilepsy, lymphoma and leukemia, blood pressure regulation, metabolic syndrome, and alcohol consumption.

The HXB/BXH recombinant inbred strains were derived from the Spontaneously Hypertensive Rat (SHR/Olalpcv) and the normotensive BN-Lx (BN-Lx/Cub), a Brown Norway congenic rat strain with polydactyly-luxate syndrome. The FXLE x LEXF recombinant inbred strains were derived from the Long Evans strain (LE/Stm) and the Fischer F344 strain (F344/Stm).

The strains included in the HRDP panel are:


Strain RGD ID Strain RGD ID Strain RGD ID
ACI/EurMcwi* 7364991 HTX/Kyo 1302600 PD/Cub 728161
BDIX/NemOda 2304285 LE/Stm* 629485 PVG/Seac* 1302722
BN/NHsdMcwi* 61498 LEW/Crl* 737932 RCS/LavRrrc 1358258
BN-Lx/Cub* 61117 LH/MavRrrc* 60990 SBH/Ygl 631572
BUF/Mna* 61118 LL/MavRrrc* 68077 SBN/Ygl 631573
COP/CrCrl 1358153 LN/MavRrrc* 61015 SHR/OlaIpcv* 631848
DA/OlaHsd* 734475 LOU/MNCr 9999143 SHRSP/A3NCrl* 2311051
F344/NCrl* 737926 M520/N* 10024 SR/JrHsd* 1582184
F344/Stm* 1302686 MNS/N 2307319 SS/JrHsdMcwi* 61499
FHH/EurMcwi* 629509 MR/N* 70449 WAG/RijCrl* 2312498
GK/FarMcwi* 10395297 MWF/Hsd* 737906 WKY/NCrl* 1358112



Note: * Sequence Available. The VCF files for these (48 strains in total) are available for download. These data have been mapped to both Rn6 and Rn7 and can be accessed here.

SHR and BN-Lx derived RI strains Long Evans and F344 derived RI strains
Strain RGD ID Strain RGD ID
HXB/lpcv RI panel 61099 FXLE/Stm RI panel 7244374
BXH/lpcv RI panel 61098 LEXF/Stm RI panel 629500



RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.