Ddhd2 (DDHD domain containing 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ddhd2 (DDHD domain containing 2) Rattus norvegicus
Analyze
Symbol: Ddhd2
Name: DDHD domain containing 2
RGD ID: 1585818
Description: Predicted to enable triglyceride lipase activity. Predicted to act upstream of or within lipid droplet organization; positive regulation of mitochondrial fission; and triglyceride catabolic process. Predicted to be located in centriolar satellite and cytosol. Predicted to be active in COPII-coated ER to Golgi transport vesicle and membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 54. Orthologous to human DDHD2 (DDHD domain containing 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC680971; phospholipase DDHD2; similar to DDHD domain containing 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,022,136 - 73,051,746 (+)NCBIGRCr8
mRatBN7.21666,319,469 - 66,349,025 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,319,466 - 66,349,023 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,598,329 - 71,625,576 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,004,642 - 75,031,883 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,244,534 - 70,271,741 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,090,096 - 71,120,713 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,090,045 - 71,118,552 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,751,567 - 70,781,622 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,694,412 - 70,723,046 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1664,229,544 - 64,256,544 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24599962   PMID:25267624   PMID:26790472   PMID:27198176  


Genomics

Comparative Map Data
Ddhd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81673,022,136 - 73,051,746 (+)NCBIGRCr8
mRatBN7.21666,319,469 - 66,349,025 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,319,466 - 66,349,023 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,598,329 - 71,625,576 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,004,642 - 75,031,883 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,244,534 - 70,271,741 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,090,096 - 71,120,713 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,090,045 - 71,118,552 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,751,567 - 70,781,622 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,694,412 - 70,723,046 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1664,229,544 - 64,256,544 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
DDHD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38838,231,585 - 38,273,647 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl838,225,218 - 38,275,558 (+)EnsemblGRCh38hg38GRCh38
GRCh37838,089,103 - 38,120,354 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,208,264 - 38,238,143 (+)NCBINCBI36Build 36hg18NCBI36
Celera837,041,566 - 37,073,339 (+)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,623,242 - 36,654,349 (+)NCBIHuRef
CHM1_1838,291,006 - 38,322,288 (+)NCBICHM1_1
T2T-CHM13v2.0838,508,534 - 38,550,602 (+)NCBIT2T-CHM13v2.0
Ddhd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,215,351 - 26,244,502 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,215,373 - 26,244,624 (-)EnsemblGRCm39 Ensembl
GRCm38825,725,324 - 25,754,474 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,725,346 - 25,754,596 (-)EnsemblGRCm38mm10GRCm38
MGSCv37826,835,796 - 26,864,752 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36827,189,378 - 27,220,141 (-)NCBIMGSCv36mm8
Celera827,193,610 - 27,222,571 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.17NCBI
Ddhd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546313,836,409 - 13,856,431 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546313,836,401 - 13,856,430 (+)NCBIChiLan1.0ChiLan1.0
DDHD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2756,795,159 - 56,826,237 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1832,511,759 - 32,543,293 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0837,533,579 - 37,564,864 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1834,711,446 - 34,741,471 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,711,446 - 34,741,471 (+)Ensemblpanpan1.1panPan2
DDHD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11627,232,453 - 27,259,071 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,234,642 - 27,257,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,749,775 - 27,776,392 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01629,131,522 - 29,158,127 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1629,108,082 - 29,203,246 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11627,353,865 - 27,380,471 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01627,931,195 - 27,957,832 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01627,970,436 - 27,997,058 (-)NCBIUU_Cfam_GSD_1.0
Ddhd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494349,842,339 - 49,867,288 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367101,593,946 - 1,618,828 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367101,593,899 - 1,616,572 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDHD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,252,338 - 48,292,181 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,239,932 - 48,292,413 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,414,923 - 55,455,128 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DDHD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1836,246,966 - 36,278,543 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl836,247,114 - 36,275,899 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660525,712,254 - 5,742,168 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ddhd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247805,376,615 - 5,398,221 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247805,374,616 - 5,398,061 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ddhd2
68 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:250
Count of miRNA genes:91
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000020832, ENSRNOT00000065062, ENSRNOT00000065770
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 38 27 11 19 11 8 8 74 33 38 11 8
Low 1 5 30 30 30 3 2 3
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000020832   ⟹   ENSRNOP00000020832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,319,466 - 66,348,513 (+)Ensembl
Rnor_6.0 Ensembl1671,090,045 - 71,118,552 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117689   ⟹   ENSRNOP00000096096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,320,657 - 66,349,023 (+)Ensembl
RefSeq Acc Id: NM_001318416   ⟹   NP_001305345
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,022,352 - 73,049,554 (+)NCBI
mRatBN7.21666,319,625 - 66,346,833 (+)NCBI
Rnor_6.01671,090,223 - 71,118,529 (+)NCBI
Celera1664,229,544 - 64,256,544 (+)NCBI
Sequence:
RefSeq Acc Id: XM_001059724   ⟹   XP_001059724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,022,136 - 73,051,746 (+)NCBI
mRatBN7.21666,319,469 - 66,349,025 (+)NCBI
Rnor_6.01671,090,096 - 71,120,713 (+)NCBI
Rnor_5.01670,751,567 - 70,781,622 (+)NCBI
RGSC_v3.41670,694,412 - 70,723,046 (+)RGD
Sequence:
RefSeq Acc Id: XM_006253338   ⟹   XP_006253400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,023,487 - 73,051,746 (+)NCBI
mRatBN7.21666,320,761 - 66,349,025 (+)NCBI
Rnor_6.01671,091,409 - 71,120,713 (+)NCBI
Rnor_5.01670,751,567 - 70,781,622 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253339   ⟹   XP_006253401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,022,168 - 73,051,746 (+)NCBI
mRatBN7.21666,319,547 - 66,349,025 (+)NCBI
Rnor_6.01671,090,194 - 71,120,713 (+)NCBI
Rnor_5.01670,751,567 - 70,781,622 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771368   ⟹   XP_008769590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,022,200 - 73,051,746 (+)NCBI
mRatBN7.21666,319,547 - 66,349,025 (+)NCBI
Rnor_6.01671,090,194 - 71,120,713 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094820   ⟹   XP_038950748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,022,200 - 73,049,391 (+)NCBI
mRatBN7.21666,319,547 - 66,345,212 (+)NCBI
RefSeq Acc Id: XM_063275720   ⟹   XP_063131790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,022,180 - 73,051,746 (+)NCBI
RefSeq Acc Id: XM_063275721   ⟹   XP_063131791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,022,200 - 73,041,535 (+)NCBI
RefSeq Acc Id: XR_005494673
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81673,022,200 - 73,037,072 (+)NCBI
mRatBN7.21666,319,547 - 66,334,345 (+)NCBI
RefSeq Acc Id: XP_001059724   ⟸   XM_001059724
- Peptide Label: isoform X1
- UniProtKB: D3ZJ91 (UniProtKB/TrEMBL),   A0A8I6AUM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253401   ⟸   XM_006253339
- Peptide Label: isoform X1
- UniProtKB: D3ZJ91 (UniProtKB/TrEMBL),   A0A8I6AUM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253400   ⟸   XM_006253338
- Peptide Label: isoform X5
- UniProtKB: D3ZJ91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769590   ⟸   XM_008771368
- Peptide Label: isoform X2
- UniProtKB: D3ZJ91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001305345   ⟸   NM_001318416
- UniProtKB: D3ZJ91 (UniProtKB/TrEMBL),   A0A8I6AUM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020832   ⟸   ENSRNOT00000020832
RefSeq Acc Id: XP_038950748   ⟸   XM_039094820
- Peptide Label: isoform X3
- UniProtKB: D3ZJ91 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000096096   ⟸   ENSRNOT00000117689
RefSeq Acc Id: XP_063131790   ⟸   XM_063275720
- Peptide Label: isoform X2
- UniProtKB: D3ZJ91 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131791   ⟸   XM_063275721
- Peptide Label: isoform X4
- UniProtKB: D3ZJ91 (UniProtKB/TrEMBL)
Protein Domains
DDHD   WWE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJ91-F1-model_v2 AlphaFold D3ZJ91 1-699 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700168
Promoter ID:EPDNEW_R10692
Type:initiation region
Name:Ddhd2_1
Description:DDHD domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01671,090,107 - 71,090,167EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585818 AgrOrtholog
BioCyc Gene G2FUF-10973 BioCyc
Ensembl Genes ENSRNOG00000015501 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020832.9 UniProtKB/TrEMBL
  ENSRNOT00000117689.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
InterPro DDHD UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM_type UniProtKB/TrEMBL
  WWE-dom UniProtKB/TrEMBL
KEGG Report rno:680971 UniProtKB/TrEMBL
NCBI Gene 680971 ENTREZGENE
PANTHER PA-PL1 PHOSPHOLIPASE FAMILY UniProtKB/TrEMBL
  PHOSPHOLIPASE DDHD2 UniProtKB/TrEMBL
Pfam DDHD UniProtKB/TrEMBL
  SAM_1 UniProtKB/TrEMBL
  WWE UniProtKB/TrEMBL
PhenoGen Ddhd2 PhenoGen
PROSITE DDHD UniProtKB/TrEMBL
  PIPLC_X_DOMAIN UniProtKB/TrEMBL
  WWE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015501 RatGTEx
SMART DDHD UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
Superfamily-SCOP SAM_homology UniProtKB/TrEMBL
UniProt A0A8I6AUM0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJ91 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Ddhd2  DDHD domain containing 2  LOC680971  similar to DDHD domain containing 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC680971  similar to DDHD domain containing 2      Symbol and Name status set to provisional 70820 PROVISIONAL