Ass1 (argininosuccinate synthase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ass1 (argininosuccinate synthase 1) Rattus norvegicus
Analyze
Symbol: Ass1
Name: argininosuccinate synthase 1
RGD ID: 2163
Description: Enables argininosuccinate synthase activity and toxic substance binding activity. Involved in several processes, including L-amino acid metabolic process; cellular response to cAMP; and cellular response to cytokine stimulus. Located in cell body fiber; mitochondrial outer membrane; and perikaryon. Biomarker of uveitis. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Orthologous to human ASS1 (argininosuccinate synthase 1); PARTICIPATES IN urea cycle pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: argininosuccinate synthase; argininosuccinate synthetase; argininosuccinate synthetase 1; arginosuccinate synthetase; arginosuccinate synthetase 1; Ass; ASSA; citrulline--aspartate ligase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8335,144,765 - 35,194,632 (+)NCBIGRCr8
mRatBN7.2314,747,355 - 14,796,909 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl314,747,368 - 14,796,903 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx317,824,936 - 17,869,940 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0326,409,937 - 26,454,941 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0324,657,206 - 24,702,297 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0310,327,411 - 10,375,847 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl310,327,414 - 10,375,826 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0315,686,773 - 15,735,199 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4310,578,717 - 10,622,332 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1310,469,450 - 10,523,821 (+)NCBI
Celera39,506,506 - 9,549,757 (+)NCBICelera
RH 3.4 Map351.4RGD
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (EXP)
2,6-dimethoxyphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-dichloroaniline  (EXP)
3,4-dihydroxybenzoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-Hydroxythalidomide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetylcholine  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
AM-251  (ISO)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
azoxystrobin  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chloroquine  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
DDE  (EXP)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenamidone  (ISO)
fenpyroximate  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
furfural  (ISO)
genistein  (ISO)
glafenine  (EXP)
glyphosate  (EXP)
GW 4064  (ISO)
imidacloprid  (EXP)
inulin  (ISO)
irinotecan  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (EXP,ISO)
methidathion  (ISO)
methotrexate  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel sulfate  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
Nutlin-3  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
prothioconazole  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
Tanshinone I  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
topotecan  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP,ISO)
triticonazole  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEP)
amino acid biosynthetic process  (IEA)
argininosuccinate metabolic process  (IBA,IDA,IEA,ISO)
aspartate metabolic process  (IEA,ISO)
cellular response to amine stimulus  (IEP)
cellular response to amino acid stimulus  (IEP)
cellular response to ammonium ion  (IEP)
cellular response to cAMP  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to glucagon stimulus  (IEP)
cellular response to laminar fluid shear stress  (IEA,ISO)
cellular response to lipopolysaccharide  (IEP)
cellular response to oleic acid  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to type II interferon  (IEP)
circadian rhythm  (IEA,ISO,ISS)
citrulline metabolic process  (IEA,ISO)
diaphragm development  (IEP)
kidney development  (IEP)
L-arginine biosynthetic process  (IBA,IDA,IEA,IMP,ISO)
liver development  (IEP)
midgut development  (IEP)
negative regulation of leukocyte cell-cell adhesion  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
response to amine  (IEP)
response to amino acid  (IEP)
response to estradiol  (IEP)
response to fatty acid  (IEP)
response to glucocorticoid  (IDA)
response to growth hormone  (IEP)
response to lipopolysaccharide  (IEP)
response to mycotoxin  (IDA)
response to nutrient  (IEP)
response to peptide hormone  (IEP)
response to steroid hormone  (IEP)
response to toxic substance  (IEP)
response to xenobiotic stimulus  (IEP)
response to zinc ion  (IDA)
urea cycle  (IBA,IDA,IEA,IMP,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Decreased urea synthesis in cafeteria-diet-induced obesity in the rat. Barber T, etal., Biochem J. 1985 Sep 15;230(3):675-81.
2. Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons. Bizzoco E, etal., Exp Neurol. 2006 Dec 30;.
3. Activated microglia cells express argininosuccinate synthetase and argininosuccinate lyase in the rat brain after transient ischemia. Bizzoco E, etal., Exp Neurol. 2007 Nov;208(1):100-9. Epub 2007 Aug 17.
4. Estrogen regulation of the rat anterior pituitary gland proteome. Blake CA, etal., Exp Biol Med (Maywood). 2005 Dec;230(11):800-7.
5. Regulation of argininosuccinate synthetase mRNA level in rat foetal hepatocytes. Bourgeois P, etal., Eur J Biochem. 1997 Nov 1;249(3):669-74.
6. Hyperammonemia: regulation of argininosuccinate synthetase and argininosuccinate lyase genes in aggregating cell cultures of fetal rat brain. Braissant O, etal., Neurosci Lett. 1999 May 7;266(2):89-92.
7. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
8. Argininosuccinate synthetase and argininosuccinate lyase are localized around mitochondria: an immunocytochemical study. Cohen NS and Kuda A, J Cell Biochem. 1996 Mar 1;60(3):334-40.
9. Arginine-metabolizing enzymes in the developing rat small intestine. De Jonge WJ, etal., Pediatr Res. 1998 Apr;43(4 Pt 1):442-51.
10. Ontogenesis of nitric oxide synthases in the ventilatory muscles. El Dwairi Q, etal., Am J Respir Cell Mol Biol. 1998 Jun;18(6):844-52.
11. Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo. Ensor CM, etal., Cancer Res. 2002 Oct 1;62(19):5443-50.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Modulation of intestinal urea cycle by dietary spermine in suckling rat. Gharbi M, etal., Biochem Biophys Res Commun. 2005 Nov 4;336(4):1119-24.
14. Expression of the genes of arginine-synthesizing enzymes in the rat kidney during development. Goutal I, etal., Biol Neonate. 1999 Oct;76(4):253-60.
15. Effects of growth hormone on steroid-induced increase in ability of urea synthesis and urea enzyme mRNA levels. Grofte T, etal., Am J Physiol. 1998 Jul;275(1 Pt 1):E79-86.
16. Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production. Guerreiro JR, etal., J Biol Chem. 2009 Jul 24;284(30):20022-33. doi: 10.1074/jbc.M109.021089. Epub 2009 Jun 2.
17. Inability of rat alveolar macrophages to recycle L-citrulline to L-arginine despite induction of argininosuccinate synthetase mRNA and protein, and inhibition of nitric oxide synthesis by exogenous L-citrulline. Hammermann R, etal., Naunyn Schmiedebergs Arch Pharmacol. 1998 Dec;358(6):601-7.
18. Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease. Heneka MT, etal., J Neuropathol Exp Neurol. 2001 Sep;60(9):906-16.
19. Induction of astrocyte argininosuccinate synthetase and argininosuccinate lyase by dibutyryl cyclic AMP and dexamethasone. Jackson MJ, etal., Neurochem Res. 1996 Oct;21(10):1161-5.
20. Identification of fumonisin B1 as an inhibitor of argininosuccinate synthetase using fumonisin affinity chromatography and in vitro kinetic studies. Jenkins GR, etal., J Biochem Mol Toxicol. 2000;14(6):320-8.
21. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
22. Nature and frequency of mutations in the argininosuccinate synthetase gene that cause classical citrullinemia. Kobayashi K, etal., Hum Genet. 1995 Oct;96(4):454-63.
23. Maternal supplementation with citrulline increases renal nitric oxide in young spontaneously hypertensive rats and has long-term antihypertensive effects. Koeners MP, etal., Hypertension. 2007 Dec;50(6):1077-84. Epub 2007 Oct 15.
24. Coinduction of nitric oxide synthase and arginine metabolic enzymes in endotoxin-induced uveitis rats. Koga T, etal., Exp Eye Res 2002 Dec;75(6):659-67.
25. Induction of citrulline-nitric oxide (NO) cycle enzymes and NO production in immunostimulated rat RPE-J cells. Koga T, etal., Exp Eye Res. 2003 Jan;76(1):15-21.
26. Intracellular localization of HSP73 and HSP90 in rat kidneys with acute lysosomal thesaurismosis. Komatsuda A, etal., Pathol Int. 1999 Jun;49(6):513-8.
27. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
28. Glutamine and regulation of gene expression in rat hepatocytes: the role of cell swelling. Lavoinne A, etal., Biochimie. 1998 Oct;80(10):807-11.
29. Identification of salt-sensitive genes in the kidneys of Dahl rats. Lighthall GK, etal., J Hypertens. 2004 Aug;22(8):1487-94.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. The 'intestinal-renal' arginine biosynthetic axis in the aging rat. Mistry SK, etal., Mech Ageing Dev. 2002 Apr 30;123(8):1159-65.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Effect of lipopolysaccharide on in vivo and genetic regulation of rat urea synthesis. Nielsen SS, etal., Liver Int. 2005 Feb;25(1):177-83.
34. Identification of novel protein targets regulated by maternal dietary fatty acid composition in neonatal rat liver. Novak EM, etal., J Proteomics. 2009 Nov 2;73(1):41-9. Epub 2009 Aug 3.
35. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
36. Coinduction of endothelial nitric oxide synthase and arginine recycling enzymes in aorta of diabetic rats. Oyadomari S, etal., Nitric Oxide. 2001 Jun;5(3):252-60.
37. An adenosine derivative compound, IFC305, reverses fibrosis and alters gene expression in a pre-established CCl(4)-induced rat cirrhosis. Perez-Carreon JI, etal., Int J Biochem Cell Biol. 2010 Feb;42(2):287-96. Epub 2009 Nov 13.
38. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
39. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
40. GOA pipeline RGD automated data pipeline
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Comprehensive gene review and curation RGD comprehensive gene curation
44. [Nitrogen detoxification in artificially-fed zinc-deficient rats] Roth VH J Anim Physiol Anim Nutr (Berl). 2001 Jun;85(5-6):158-63.
45. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
46. Nucleotide sequence of the cDNA encoding the rat argininosuccinate synthetase. Surh LC, etal., Nucleic Acids Res 1988 Oct 11;16(19):9352.
47. Nitric oxide (no), citrulline - no cycle enzymes, glutamine synthetase and oxidative stress in anoxia (hypobaric hypoxia) and reperfusion in rat brain. Swamy M, etal., Int J Med Sci. 2010 May 31;7(3):147-54.
48. Regulation of genes for inducible nitric oxide synthase and urea cycle enzymes in rat liver in endotoxin shock. Tabuchi S, etal., Biochem Biophys Res Commun. 2000 Feb 5;268(1):221-4.
49. Polyaspartoyl.l-arginine inhibits platelet aggregation through stimulation of NO release from endothelial cells. Tang Z, etal., Eur J Pharmacol. 2008 Jun 24;588(1):41-6. Epub 2008 Apr 9.
50. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
51. Long-chain fatty acids suppress the induction of urea cycle enzyme genes by glucocorticoid action. Tomomura M, etal., FEBS Lett. 1996 Dec 16;399(3):310-2.
52. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
53. Expression of liver functions following sub-lethal and non-lethal doses of allyl alcohol and acetaminophen in the rat. Tygstrup N, etal., J Hepatol. 1997 Jul;27(1):156-62.
54. L-Citrulline attenuates arrested alveolar growth and pulmonary hypertension in oxygen-induced lung injury in newborn rats. Vadivel A, etal., Pediatr Res. 2010 Aug 27.
55. L-citrulline recycling by argininosuccinate synthetase and lyase in rat gastric fundus. Van Geldre LA, etal., Eur J Pharmacol. 2002 Nov 29;455(2-3):149-60.
56. Urea cycle gene expression is suppressed by PFOA treatment in rats. Walters MW and Wallace KB, Toxicol Lett. 2010 Aug 1;197(1):46-50. Epub 2010 May 7.
57. Plasma and liver proteomic analysis of 3Z-3-[(1H-pyrrol-2-yl)-methylidene]-1-(1-piperidinylmethyl)-1,3-2H-indol-2 -one-induced hepatotoxicity in Wistar rats. Wang Y, etal., Proteomics. 2010 Aug;10(16):2927-41.
58. Coinduction of inducible nitric oxide synthase and arginine recycling enzymes in cytokine-stimulated PC12 cells and high output production of nitric oxide. Zhang WY, etal., Brain Res Mol Brain Res. 2000 Nov 10;83(1-2):1-8.
Additional References at PubMed
PMID:7977368   PMID:8792870   PMID:14701727   PMID:15192091   PMID:15489334   PMID:16189514   PMID:16809898   PMID:17634366   PMID:18473344   PMID:19056867   PMID:21106532   PMID:21988832  
PMID:22658674   PMID:23376485   PMID:23533145   PMID:24625528   PMID:25416956   PMID:25931508   PMID:27247419   PMID:27287393   PMID:28985504  


Genomics

Comparative Map Data
Ass1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8335,144,765 - 35,194,632 (+)NCBIGRCr8
mRatBN7.2314,747,355 - 14,796,909 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl314,747,368 - 14,796,903 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx317,824,936 - 17,869,940 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0326,409,937 - 26,454,941 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0324,657,206 - 24,702,297 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0310,327,411 - 10,375,847 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl310,327,414 - 10,375,826 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0315,686,773 - 15,735,199 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4310,578,717 - 10,622,332 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1310,469,450 - 10,523,821 (+)NCBI
Celera39,506,506 - 9,549,757 (+)NCBICelera
RH 3.4 Map351.4RGD
Cytogenetic Map3p12NCBI
ASS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389130,444,707 - 130,501,274 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9130,444,961 - 130,501,274 (+)EnsemblGRCh38hg38GRCh38
GRCh379133,320,094 - 133,376,661 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369132,309,915 - 132,366,482 (+)NCBINCBI36Build 36hg18NCBI36
Build 349130,355,212 - 130,406,214NCBI
Celera9103,858,652 - 103,915,182 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9102,805,927 - 102,862,325 (+)NCBIHuRef
CHM1_19133,469,032 - 133,525,591 (+)NCBICHM1_1
T2T-CHM13v2.09142,649,688 - 142,706,251 (+)NCBIT2T-CHM13v2.0
Ass1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39231,360,282 - 31,410,682 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl231,360,219 - 31,410,684 (+)EnsemblGRCm39 Ensembl
GRCm38231,470,270 - 31,520,670 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl231,470,207 - 31,520,672 (+)EnsemblGRCm38mm10GRCm38
MGSCv37231,325,790 - 31,376,190 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36231,292,279 - 31,342,679 (+)NCBIMGSCv36mm8
Celera231,171,177 - 31,221,646 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.81NCBI
Ass1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955513445,462 - 485,190 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955513443,372 - 485,190 (+)NCBIChiLan1.0ChiLan1.0
ASS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2118,850,519 - 8,907,008 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan198,852,843 - 8,909,350 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09101,569,442 - 101,625,899 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19130,219,993 - 130,276,036 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9130,219,993 - 130,276,036 (+)Ensemblpanpan1.1panPan2
ASS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1953,425,228 - 53,478,007 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl953,425,448 - 53,477,904 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha952,620,886 - 52,673,553 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0954,321,815 - 54,374,466 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl954,321,824 - 54,374,426 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1953,099,205 - 53,151,882 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0953,420,445 - 53,473,009 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0953,512,940 - 53,565,629 (-)NCBIUU_Cfam_GSD_1.0
Ass1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947197,713,780 - 197,758,880 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648717,486,826 - 17,527,435 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648717,482,307 - 17,527,407 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1270,531,589 - 270,586,364 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11270,531,434 - 270,586,364 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21304,454,038 - 304,508,986 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1127,643,484 - 7,701,334 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660797,757,994 - 7,815,954 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ass1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247605,180,095 - 5,221,732 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247605,180,095 - 5,221,677 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ass1
361 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:84
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000012075
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000012075   ⟹   ENSRNOP00000012075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl314,747,368 - 14,795,836 (+)Ensembl
Rnor_6.0 Ensembl310,327,414 - 10,371,240 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093365   ⟹   ENSRNOP00000076301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl314,747,368 - 14,796,903 (+)Ensembl
Rnor_6.0 Ensembl310,327,417 - 10,375,826 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl310,346,123 - 10,354,365 (-)Ensembl
RefSeq Acc Id: NM_013157   ⟹   NP_037289
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8335,149,730 - 35,194,610 (+)NCBI
mRatBN7.2314,752,004 - 14,796,887 (+)NCBI
Rnor_6.0310,327,433 - 10,371,190 (-)NCBI
Rnor_5.0315,686,773 - 15,735,199 (-)NCBI
RGSC_v3.4310,578,717 - 10,622,332 (+)RGD
Celera39,506,506 - 9,549,757 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233911   ⟹   XP_006233973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8335,144,765 - 35,194,632 (+)NCBI
mRatBN7.2314,747,355 - 14,796,909 (+)NCBI
Rnor_6.0310,327,411 - 10,375,847 (-)NCBI
Rnor_5.0315,686,773 - 15,735,199 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_037289 (Get FASTA)   NCBI Sequence Viewer  
  XP_006233973 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40771 (Get FASTA)   NCBI Sequence Viewer  
  AAH63146 (Get FASTA)   NCBI Sequence Viewer  
  CAA30999 (Get FASTA)   NCBI Sequence Viewer  
  EDL93273 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000076301
  ENSRNOP00000076301.1
GenBank Protein P09034 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037289   ⟸   NM_013157
- UniProtKB: P09034 (UniProtKB/Swiss-Prot),   A6JU24 (UniProtKB/TrEMBL),   A0A8L2Q5M6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233973   ⟸   XM_006233911
- Peptide Label: isoform X1
- UniProtKB: P09034 (UniProtKB/Swiss-Prot),   A6JU24 (UniProtKB/TrEMBL),   A0A8L2Q5M6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012075   ⟸   ENSRNOT00000012075
Ensembl Acc Id: ENSRNOP00000076301   ⟸   ENSRNOT00000093365
Protein Domains
Arginosuccinate synthase C-terminal   Arginosuccinate synthase-like N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09034-F1-model_v2 AlphaFold P09034 1-412 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691984
Promoter ID:EPDNEW_R2500
Type:multiple initiation site
Name:Ass1_1
Description:argininosuccinate synthase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0310,375,777 - 10,375,837EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2163 AgrOrtholog
BioCyc Gene G2FUF-50178 BioCyc
BioCyc Pathway PWY-4983 [nitric oxide biosynthesis II (mammals)] BioCyc
  PWY-4984 [urea cycle] BioCyc
BioCyc Pathway Image PWY-4983 BioCyc
  PWY-4984 BioCyc
Ensembl Genes ENSRNOG00000008837 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000093365 ENTREZGENE
  ENSRNOT00000093365.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.620 UniProtKB/Swiss-Prot
  3.90.1260.10 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6888536 IMAGE-MGC_LOAD
InterPro Arginosuc_syn_C UniProtKB/Swiss-Prot
  Arginosuc_syn_N UniProtKB/Swiss-Prot
  Arginosuc_synth UniProtKB/Swiss-Prot
  Arginosuc_synth_CS UniProtKB/Swiss-Prot
  Arginosuc_synth_type_1_subfam UniProtKB/Swiss-Prot
  AS_cat/multimer_dom_body UniProtKB/Swiss-Prot
  Rossmann-like_a/b/a_fold UniProtKB/Swiss-Prot
KEGG Report rno:25698 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72667 IMAGE-MGC_LOAD
NCBI Gene 25698 ENTREZGENE
PANTHER ARGININOSUCCINATE SYNTHASE UniProtKB/Swiss-Prot
  PTHR11587 UniProtKB/Swiss-Prot
Pfam Arginosuc_syn_C UniProtKB/Swiss-Prot
  Arginosuc_synth UniProtKB/Swiss-Prot
PhenoGen Ass1 PhenoGen
PROSITE ARGININOSUCCIN_SYN_1 UniProtKB/Swiss-Prot
  ARGININOSUCCIN_SYN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008837 RatGTEx
Superfamily-SCOP Adenine nucleotide alpha hydrolases-like UniProtKB/Swiss-Prot
  SSF69864 UniProtKB/Swiss-Prot
TIGR TC217091
UniProt A0A8L2Q5M6 ENTREZGENE, UniProtKB/TrEMBL
  A6JU24 ENTREZGENE, UniProtKB/TrEMBL
  ASSY_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Ass1  argininosuccinate synthase 1  Ass1  argininosuccinate synthetase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-14 Ass1  argininosuccinate synthetase 1  Ass  argininosuccinate synthetase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Ass  argininosuccinate synthetase  Ass  arginosuccinate synthetase  Name updated 1299863 APPROVED
2003-04-09 Ass  arginosuccinate synthetase  Ass  arginosuccinate synthetase 1  Name updated 629478 APPROVED
2002-06-10 Ass  arginosuccinate synthetase 1      Symbol and Name status set to approved 70586 APPROVED
2001-06-20 Ass1  Arginosuccinate synthetase 1      Symbol withdrawn, duplicate of Ass (RGD:2163) 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_process important enzyme for arginine biosynthesis 631755
gene_regulation mRNA and protein are induced by endotoxin-induced uveitis 631755