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Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models.

Authors: Tygstrup, N  Bangert, K  Ott, P  Bisgaard, HC 
Citation: Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
Pubmed: (View Article at PubMed) PMID:11779202
DOI: Full-text: DOI:10.1006/bbrc.2001.6216

Liver damage activates processes aimed at repairing damage; simultaneously, liver functions required for survival must be maintained. The expression of genes responsible for both in rat models of lethal (lipopolysaccharide, 90% hepatectomy, and d-galactosamine) and nonlethal (turpentine, 70% hepatectomy, and acetaminophen) liver damage and stress was measured at 3, 6, 12, and 24 h after the intervention and quantitated as the area between the control curves and the test curves (AUC). The expression of genes for cell division and remodeling was upregulated most in the lethal models. The expression of most liver-specific function genes was reduced. Positive AUC was found for ARG, ASL, CPT1, Mdr1b, Mdr2, and PEPCK. It is concluded that a high expression of genes for repair of liver damage is associated with reduced expression of genes for several liver-specific functions, possibly reflecting a limited capacity for transcriptional activity. Maintained or increased expression of selected function genes indicates that the corresponding functions have high priority. The liver sustains metabolic homeostasis ensuring that other organs in the body function normally. Simultaneously, the processes required for the integrity of its own structure and function are maintained as a result of regulated expression of the genes that produce the proteins needed to perform both set of functions. (c)2002 Elsevier Science.


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RGD Object Information
RGD ID: 70249
Created: 2002-02-15
Species: All species
Last Modified: 2002-02-15
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.