RGD Reference Report - Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. - Rat Genome Database

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Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models.

Authors: Tygstrup, N  Bangert, K  Ott, P  Bisgaard, HC 
Citation: Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
RGD ID: 70249
Pubmed: (View Article at PubMed) PMID:11779202
DOI: Full-text: DOI:10.1006/bbrc.2001.6216

Liver damage activates processes aimed at repairing damage; simultaneously, liver functions required for survival must be maintained. The expression of genes responsible for both in rat models of lethal (lipopolysaccharide, 90% hepatectomy, and d-galactosamine) and nonlethal (turpentine, 70% hepatectomy, and acetaminophen) liver damage and stress was measured at 3, 6, 12, and 24 h after the intervention and quantitated as the area between the control curves and the test curves (AUC). The expression of genes for cell division and remodeling was upregulated most in the lethal models. The expression of most liver-specific function genes was reduced. Positive AUC was found for ARG, ASL, CPT1, Mdr1b, Mdr2, and PEPCK. It is concluded that a high expression of genes for repair of liver damage is associated with reduced expression of genes for several liver-specific functions, possibly reflecting a limited capacity for transcriptional activity. Maintained or increased expression of selected function genes indicates that the corresponding functions have high priority. The liver sustains metabolic homeostasis ensuring that other organs in the body function normally. Simultaneously, the processes required for the integrity of its own structure and function are maintained as a result of regulated expression of the genes that produce the proteins needed to perform both set of functions. (c)2002 Elsevier Science.


Disease Annotations    
Liver Failure  (IEP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Arg1  (arginase 1)
Asl  (argininosuccinate lyase)
Ass1  (argininosuccinate synthase 1)
Cps1  (carbamoyl-phosphate synthase 1)
Otc  (ornithine transcarbamylase)

Genes (Mus musculus)
Arg1  (arginase, liver)
Asl  (argininosuccinate lyase)
Ass1  (argininosuccinate synthetase 1)
Cps1  (carbamoyl-phosphate synthetase 1)
Otc  (ornithine transcarbamylase)

Genes (Homo sapiens)
ARG1  (arginase 1)
ASL  (argininosuccinate lyase)
ASS1  (argininosuccinate synthase 1)
CPS1  (carbamoyl-phosphate synthase 1)
OTC  (ornithine transcarbamylase)

Objects referenced in this article
Gene A2m alpha-2-macroglobulin Rattus norvegicus
Gene Abcb11 ATP binding cassette subfamily B member 11 Rattus norvegicus
Gene Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
Gene Abcb4 ATP binding cassette subfamily B member 4 Rattus norvegicus
Gene Abcc2 ATP binding cassette subfamily C member 2 Rattus norvegicus
Gene Actb actin, beta Rattus norvegicus
Gene Cebpb CCAAT/enhancer binding protein beta Rattus norvegicus
Gene Fgb fibrinogen beta chain Rattus norvegicus
Gene Gclc glutamate-cysteine ligase, catalytic subunit Rattus norvegicus
Gene Gcsh glycine cleavage system protein H Rattus norvegicus
Gene Gstp1 glutathione S-transferase pi 1 Rattus norvegicus
Gene H1f6 H1.6 linker histone, cluster member Rattus norvegicus
Gene Igfbp1 insulin-like growth factor binding protein 1 Rattus norvegicus
Gene Odc1 ornithine decarboxylase 1 Rattus norvegicus
Gene Orm1 orosomucoid 1 Rattus norvegicus
Gene Plaur plasminogen activator, urokinase receptor Rattus norvegicus
Gene Serpine1 serpin family E member 1 Rattus norvegicus
Gene Slc10a1 solute carrier family 10 member 1 Rattus norvegicus
Gene Slco1a1 solute carrier organic anion transporter family, member 1a1 Rattus norvegicus
Gene Slco1c1 solute carrier organic anion transporter family, member 1c1 Rattus norvegicus
Gene Tuba1a tubulin, alpha 1A Rattus norvegicus

Additional Information