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Gene: Asl (argininosuccinate lyase) Mus musculus
Symbol: Asl
Name: argininosuccinate lyase
Description: Predicted to have argininosuccinate lyase activity and identical protein binding activity. Involved in ammonia assimilation cycle; locomotory behavior; and post-embryonic development. Predicted to localize to several cellular components, including cell body fiber; mitochondrial outer membrane; and perikaryon. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study argininosuccinic aciduria. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; argininosuccinic aciduria pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2510006M18Rik; arginosuccinase; ASAL
Homo sapiens (human) : ASL (argininosuccinate lyase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Asl (argininosuccinate lyase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Asl (argininosuccinate lyase)
Pan paniscus (bonobo/pygmy chimpanzee) : ASL (argininosuccinate lyase)
Canis lupus familiaris (dog) : ASL (argininosuccinate lyase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Asl (argininosuccinate lyase)
Sus scrofa (pig) : ASL (argininosuccinate lyase)
Chlorocebus sabaeus (African green monkey) : ASL (argininosuccinate lyase)
Heterocephalus glaber (naked mole-rat) : Asl (argininosuccinate lyase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl5130,011,258 - 130,029,247 (-)EnsemblGRCm38mm10GRCm38
GRCm385130,011,258 - 130,024,381 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375130,487,373 - 130,500,201 (-)NCBIGRCm37mm9NCBIm37
MGSCv365130,296,206 - 130,309,034 (-)NCBImm8
Celera5127,015,654 - 127,028,488 (-)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map568.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Asl
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731560
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.