Asl (argininosuccinate lyase) - Rat Genome Database

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Gene: Asl (argininosuccinate lyase) Mus musculus
Analyze
Symbol: Asl
Name: argininosuccinate lyase
RGD ID: 731560
MGI Page MGI
Description: Predicted to enable argininosuccinate lyase activity and identical protein binding activity. Involved in arginine biosynthetic process and positive regulation of nitric oxide biosynthetic process. Acts upstream of or within ammonia assimilation cycle; locomotory behavior; and post-embryonic development. Predicted to be located in several cellular components, including cell body fiber; mitochondrial outer membrane; and perikaryon. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study argininosuccinic aciduria. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2510006M18Rik; arginosuccinase; ASAL
RGD Orthologs
Human
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395130,040,099 - 130,053,222 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5130,040,099 - 130,058,088 (-)EnsemblGRCm39 Ensembl
GRCm385130,011,258 - 130,024,381 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5130,011,258 - 130,029,247 (-)EnsemblGRCm38mm10GRCm38
MGSCv375130,487,373 - 130,500,201 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365130,296,206 - 130,309,034 (-)NCBIMGSCv36mm8
Celera5127,015,654 - 127,028,488 (-)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map568.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium acetate  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloroform  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (EXP)
fenthion  (EXP)
folic acid  (EXP)
fumonisin B1  (EXP)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
indometacin  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP)
N-nitrosomorpholine  (ISO)
nickel dichloride  (ISO)
ochratoxin A  (ISO)
oxycodone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (EXP)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (EXP)
rac-lactic acid  (ISO)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal circulating amino acid level  (IAGP)
abnormal coat/ hair morphology  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal food intake  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal nitric oxide homeostasis  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
acanthocytosis  (IAGP)
decreased body weight  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating arginine level  (IAGP)
decreased circulating aspartate transaminase level  (IAGP)
decreased creatinine clearance  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased spleen germinal center number  (IAGP)
decreased systemic arterial diastolic blood pressure  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased vasodilation  (IAGP)
epidermal atrophy  (IAGP)
increased circulating ammonia level  (IAGP)
increased circulating citrulline level  (IAGP)
increased circulating glutamine level  (IAGP)
increased macrophage cell number  (IAGP)
increased spleen red pulp amount  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
lethargy  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
small hair follicles  (IAGP)
thymus cortex hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Decreased urea synthesis in cafeteria-diet-induced obesity in the rat. Barber T, etal., Biochem J. 1985 Sep 15;230(3):675-81.
2. Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons. Bizzoco E, etal., Exp Neurol. 2006 Dec 30;.
3. Hyperammonemia: regulation of argininosuccinate synthetase and argininosuccinate lyase genes in aggregating cell cultures of fetal rat brain. Braissant O, etal., Neurosci Lett. 1999 May 7;266(2):89-92.
4. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Clinical, enzymatic, and molecular genetic characterization of a biochemical variant type of argininosuccinic aciduria: prenatal and postnatal diagnosis in five unrelated families. Kleijer WJ, etal., J Inherit Metab Dis 2002 Sep;25(5):399-410.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus. Rao PV, etal., J Assoc Physicians India. 2005 Jun;53:521-6.
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Molecular basis of enzyme abnormalities in urea cycle disorders. With special reference to citrullinemia and argininosuccinic aciduria. Saheki T, etal., Enzyme. 1987;38(1-4):227-32.
18. Nitric oxide (no), citrulline - no cycle enzymes, glutamine synthetase and oxidative stress in anoxia (hypobaric hypoxia) and reperfusion in rat brain. Swamy M, etal., Int J Med Sci. 2010 May 31;7(3):147-54.
19. Regulation of genes for inducible nitric oxide synthase and urea cycle enzymes in rat liver in endotoxin shock. Tabuchi S, etal., Biochem Biophys Res Commun. 2000 Feb 5;268(1):221-4.
20. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
21. L-Citrulline attenuates arrested alveolar growth and pulmonary hypertension in oxygen-induced lung injury in newborn rats. Vadivel A, etal., Pediatr Res. 2010 Aug 27.
22. Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s). Valero MC, etal., Genomics 2000 Oct 1;69(1):1-13.
23. Molecular analysis of human argininosuccinate lyase: mutant characterization and alternative splicing of the coding region. Walker DC, etal., Proc Natl Acad Sci U S A 1990 Dec;87(24):9625-9.
Additional References at PubMed
PMID:2644168   PMID:7504460   PMID:8889548   PMID:9337408   PMID:9878248   PMID:10198163   PMID:10349636   PMID:10575226   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11092456  
PMID:11352562   PMID:12477932   PMID:12559843   PMID:12819125   PMID:14681479   PMID:15472464   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17933574   PMID:18799693  
PMID:21267068   PMID:21873635   PMID:22081021   PMID:22496890   PMID:22541557   PMID:24904080   PMID:29768197   PMID:30075114   PMID:30158522   PMID:30253962   PMID:30333137   PMID:30457570  
PMID:30710047   PMID:31018905   PMID:31990680   PMID:32325033   PMID:32554809   PMID:33369168   PMID:34054815   PMID:35101895   PMID:35237793   PMID:36265442   PMID:37490345   PMID:37738569  


Genomics

Comparative Map Data
Asl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395130,040,099 - 130,053,222 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5130,040,099 - 130,058,088 (-)EnsemblGRCm39 Ensembl
GRCm385130,011,258 - 130,024,381 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5130,011,258 - 130,029,247 (-)EnsemblGRCm38mm10GRCm38
MGSCv375130,487,373 - 130,500,201 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365130,296,206 - 130,309,034 (-)NCBIMGSCv36mm8
Celera5127,015,654 - 127,028,488 (-)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map568.37NCBI
ASL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38766,075,819 - 66,093,576 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl766,075,800 - 66,094,697 (+)EnsemblGRCh38hg38GRCh38
GRCh37765,540,806 - 65,558,563 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36765,178,211 - 65,195,765 (+)NCBINCBI36Build 36hg18NCBI36
Build 34764,984,963 - 65,002,090NCBI
Celera766,555,388 - 66,572,941 (-)NCBICelera
Cytogenetic Map7q11.21ENTREZGENE
HuRef761,727,625 - 61,745,174 (+)NCBIHuRef
CHM1_1765,636,440 - 65,653,994 (+)NCBICHM1_1
T2T-CHM13v2.0767,297,906 - 67,315,665 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2764,878,281 - 64,895,827 (+)NCBI
Asl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,295,779 - 32,313,257 (+)NCBIGRCr8
mRatBN7.21226,659,664 - 26,677,136 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,659,565 - 26,679,662 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1227,807,557 - 27,824,901 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,418,086 - 28,435,430 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,479,553 - 27,496,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01230,160,922 - 30,178,348 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,165,694 - 30,178,341 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,097,760 - 32,115,110 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41227,702,882 - 27,720,230 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11227,570,168 - 27,583,445 (+)NCBI
Celera1228,373,639 - 28,390,987 (+)NCBICelera
Cytogenetic Map12q12NCBI
Asl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554568,411,220 - 8,416,992 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554568,409,767 - 8,419,915 (-)NCBIChiLan1.0ChiLan1.0
ASL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.16768,522 - 779,144 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl6730,358 - 779,424 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha62,468,962 - 2,479,644 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.06573,409 - 584,014 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl6565,544 - 584,326 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.16517,146 - 527,808 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.06511,138 - 521,729 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.06682,422 - 693,029 (-)NCBIUU_Cfam_GSD_1.0
Asl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344126,336,725 - 126,347,816 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365437,688,741 - 7,699,851 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365437,688,788 - 7,699,842 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl316,637,481 - 16,646,867 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1316,637,481 - 16,646,869 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2316,889,701 - 16,899,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1281,782,434 - 1,800,581 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl281,782,553 - 1,802,517 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607014,846,508 - 14,865,029 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247408,414,733 - 8,423,777 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247408,414,664 - 8,423,797 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Asl
529 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1536
Count of miRNA genes:529
Interacting mature miRNAs:610
Transcripts:ENSMUST00000159096, ENSMUST00000159619, ENSMUST00000160129, ENSMUST00000160208, ENSMUST00000160557, ENSMUST00000161094, ENSMUST00000161640, ENSMUST00000161884, ENSMUST00000162230
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
13464142Bbaa2a_mB.burgdorferi-associated arthritis 2a (mouse)5128571199130052971Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse

Markers in Region
Asl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv375130,488,894 - 130,489,356UniSTSGRCm37
Celera5127,017,175 - 127,017,637UniSTS
Cytogenetic Map5G1.3UniSTS
cM Map574.0UniSTS
BB315002  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385130,011,507 - 130,011,652UniSTSGRCm38
MGSCv375130,487,377 - 130,487,522UniSTSGRCm37
Celera5127,015,658 - 127,015,803UniSTS
Cytogenetic Map5G1.3UniSTS
Whitehead/MRC_RH12304.32UniSTS
ASL  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385130,013,024 - 130,013,486UniSTSGRCm38
MGSCv375130,488,894 - 130,489,356UniSTSGRCm37
Celera5127,017,175 - 127,017,637UniSTS
Cytogenetic Map5G1.3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006504341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC161345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI325988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY770404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000159096   ⟹   ENSMUSP00000125143
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5130,040,335 - 130,043,563 (-)Ensembl
GRCm38.p6 Ensembl5130,011,494 - 130,014,722 (-)Ensembl
RefSeq Acc Id: ENSMUST00000159619   ⟹   ENSMUSP00000123799
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5130,040,336 - 130,058,088 (-)Ensembl
GRCm38.p6 Ensembl5130,011,495 - 130,029,247 (-)Ensembl
RefSeq Acc Id: ENSMUST00000160129   ⟹   ENSMUSP00000124579
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5130,040,345 - 130,053,860 (-)Ensembl
GRCm38.p6 Ensembl5130,011,504 - 130,025,019 (-)Ensembl
RefSeq Acc Id: ENSMUST00000160557
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5130,045,595 - 130,053,214 (-)Ensembl
GRCm38.p6 Ensembl5130,016,754 - 130,024,373 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161094   ⟹   ENSMUSP00000124274
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5130,040,099 - 130,053,222 (-)Ensembl
GRCm38.p6 Ensembl5130,011,258 - 130,024,381 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161640   ⟹   ENSMUSP00000124487
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5130,042,288 - 130,053,141 (-)Ensembl
GRCm38.p6 Ensembl5130,013,447 - 130,024,300 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161884   ⟹   ENSMUSP00000123861
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5130,048,551 - 130,053,158 (-)Ensembl
GRCm38.p6 Ensembl5130,019,710 - 130,024,317 (-)Ensembl
RefSeq Acc Id: ENSMUST00000162230
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5130,051,128 - 130,053,186 (-)Ensembl
GRCm38.p6 Ensembl5130,022,287 - 130,024,345 (-)Ensembl
RefSeq Acc Id: NM_133768   ⟹   NP_598529
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395130,040,099 - 130,053,222 (-)NCBI
GRCm385130,011,258 - 130,024,381 (-)NCBI
MGSCv375130,487,373 - 130,500,201 (-)RGD
Celera5127,015,654 - 127,028,488 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006504341   ⟹   XP_006504404
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395130,040,344 - 130,053,159 (-)NCBI
GRCm385130,011,498 - 130,024,340 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036164727   ⟹   XP_036020620
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395130,040,339 - 130,053,203 (-)NCBI
Sequence:
RefSeq Acc Id: NP_598529   ⟸   NM_133768
- UniProtKB: Q3UFA2 (UniProtKB/Swiss-Prot),   Q91YI0 (UniProtKB/Swiss-Prot),   Q3UUH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006504404   ⟸   XM_006504341
- Peptide Label: isoform X1
- UniProtKB: Q3UFA2 (UniProtKB/Swiss-Prot),   Q91YI0 (UniProtKB/Swiss-Prot),   Q3UUH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000125143   ⟸   ENSMUST00000159096
RefSeq Acc Id: ENSMUSP00000123799   ⟸   ENSMUST00000159619
RefSeq Acc Id: ENSMUSP00000124579   ⟸   ENSMUST00000160129
RefSeq Acc Id: ENSMUSP00000124487   ⟸   ENSMUST00000161640
RefSeq Acc Id: ENSMUSP00000124274   ⟸   ENSMUST00000161094
RefSeq Acc Id: ENSMUSP00000123861   ⟸   ENSMUST00000161884
RefSeq Acc Id: XP_036020620   ⟸   XM_036164727
- Peptide Label: isoform X2
- UniProtKB: F7D439 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91YI0-F1-model_v2 AlphaFold Q91YI0 1-464 view protein structure

Promoters
RGD ID:6888206
Promoter ID:EPDNEW_M7554
Type:initiation region
Name:Asl_1
Description:Mus musculus argininosuccinate lyase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385130,024,345 - 130,024,405EPDNEW
RGD ID:6848818
Promoter ID:MM_TRO:7829
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Spleen
Transcripts:MTR005894.5.2475.4,   MTR005894.5.2475.5
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365130,487,394 - 130,487,894 (-)MPROMDB
RGD ID:6847878
Promoter ID:MM_ACW:39634
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ASL.GSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365130,488,886 - 130,489,386 (-)MPROMDB
RGD ID:6837122
Promoter ID:MM_KWN:44230
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000085581
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365130,490,286 - 130,491,037 (-)MPROMDB
RGD ID:6837121
Promoter ID:MM_KWN:44231
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000085071,   OTTMUST00000085072,   OTTMUST00000085369,   OTTMUST00000085370,   OTTMUST00000085413,   OTTMUST00000085414,   OTTMUST00000085475,   OTTMUST00000085476
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365130,500,009 - 130,500,509 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88084 AgrOrtholog
Ensembl Genes ENSMUSG00000025533 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000159096 ENTREZGENE
  ENSMUST00000159096.8 UniProtKB/TrEMBL
  ENSMUST00000159619.8 UniProtKB/Swiss-Prot
  ENSMUST00000160129 ENTREZGENE
  ENSMUST00000160129.8 UniProtKB/Swiss-Prot
  ENSMUST00000161094 ENTREZGENE
  ENSMUST00000161094.8 UniProtKB/Swiss-Prot
  ENSMUST00000161640.8 UniProtKB/TrEMBL
  ENSMUST00000161884.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.275.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarase/aspartase (C-terminal domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarase/aspartase (Central domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Arg_succ_lyase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Argininosuccinate_lyase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarase/histidase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarate_lyase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarate_lyase_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fumarate_lyase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L-Aspartase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88084 ENTREZGENE
NCBI Gene 109900 ENTREZGENE
PANTHER ARGININOSUCCINATE LYASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ASL_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lyase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Asl PhenoGen
PRINTS ARGSUCLYASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FUMRATELYASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FUMARATE_LYASES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48557 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ARLY_MOUSE UniProtKB/Swiss-Prot
  E0CY49_MOUSE UniProtKB/TrEMBL
  E0CYV3_MOUSE UniProtKB/TrEMBL
  F7D439 ENTREZGENE, UniProtKB/TrEMBL
  Q3UFA2 ENTREZGENE
  Q3UUH0 ENTREZGENE, UniProtKB/TrEMBL
  Q91YI0 ENTREZGENE
UniProt Secondary Q3UFA2 UniProtKB/Swiss-Prot