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Gene: Asl (argininosuccinate lyase) Mus musculus
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Symbol: Asl
Name: argininosuccinate lyase
Description: Predicted to have argininosuccinate lyase activity and identical protein binding activity. Involved in ammonia assimilation cycle; locomotory behavior; and post-embryonic development. Predicted to localize to several cellular components, including cell body fiber; mitochondrial outer membrane; and perikaryon. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study argininosuccinic aciduria. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; argininosuccinic aciduria pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2510006M18Rik; arginosuccinase; ASAL
Orthologs:
Homo sapiens (human) : ASL (argininosuccinate lyase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Asl (argininosuccinate lyase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Asl (argininosuccinate lyase)
Pan paniscus (bonobo/pygmy chimpanzee) : ASL (argininosuccinate lyase)
Canis lupus familiaris (dog) : ASL (argininosuccinate lyase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Asl (argininosuccinate lyase)
Sus scrofa (pig) : ASL (argininosuccinate lyase)
Chlorocebus sabaeus (African green monkey) : ASL (argininosuccinate lyase)
Heterocephalus glaber (naked mole-rat) : Asl (argininosuccinate lyase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl5130,011,258 - 130,029,247 (-)EnsemblGRCm38mm10GRCm38
GRCm385130,011,258 - 130,024,381 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375130,487,373 - 130,500,201 (-)NCBIGRCm37mm9NCBIm37
MGSCv365130,296,206 - 130,309,034 (-)NCBImm8
Celera5127,015,654 - 127,028,488 (-)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map568.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Asl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731560
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.