Fgb (fibrinogen beta chain) - Rat Genome Database

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Gene: Fgb (fibrinogen beta chain) Rattus norvegicus
Analyze
Symbol: Fgb
Name: fibrinogen beta chain
RGD ID: 2604
Description: Predicted to enable chaperone binding activity and structural molecule activity. Predicted to contribute to cell adhesion molecule binding activity and signaling receptor binding activity. Involved in cellular response to interleukin-1 and cellular response to leptin stimulus. Located in blood microparticle and cytoplasm. Biomarker of pancreatitis and pulmonary embolism. Human ortholog(s) of this gene implicated in cardiovascular system disease (multiple); congenital afibrinogenemia; and end stage renal disease. Orthologous to human FGB (fibrinogen beta chain); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ab1-181; Ab1-216; Ac1-581; beta-fibrinogen; Fibrinogen B beta polypeptide; fibrinogen, B beta polypeptide; fibrinogen, beta polypeptide; liver regeneration-related protein LRRG036/LRRG043/LRRG189
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22168,394,901 - 168,402,863 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2168,394,916 - 168,405,979 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2175,586,120 - 175,593,059 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02173,607,044 - 173,613,983 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02168,208,465 - 168,215,404 (-)NCBIRnor_WKY
Rnor_6.02182,028,044 - 182,035,026 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,027,115 - 182,038,178 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02201,442,664 - 201,449,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42174,768,193 - 174,775,102 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12174,718,265 - 174,725,209 (-)NCBI
Celera2162,422,542 - 162,429,467 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
ADP  (ISO)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aniline  (EXP)
arachidonyl-2'-chloroethylamide  (ISO)
aristolochic acids  (EXP)
arotinoid acid  (ISO)
Azaspiracid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CHIR 99021  (ISO)
chromium trinitrate  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
dabigatran  (ISO)
dexamethasone  (EXP)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dienogest  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
erythromycin estolate  (EXP)
fenofibrate  (EXP)
fenvalerate  (EXP)
furan  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
gestodene  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
levonorgestrel  (ISO)
lithocholic acid  (EXP)
mercury dibromide  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nitrofen  (EXP)
norethisterone  (ISO)
norgestimate  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
potassium bromate  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
quinidine  (EXP)
Rebamipide  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
tacrolimus hydrate  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
theophylline  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (EXP,ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Beta fibrinogen gene polymorphisms are associated with plasma fibrinogen and coronary artery disease in patients with myocardial infarction. The ECTIM Study. Etude Cas-Temoins sur l'Infarctus du Myocarde. Behague I, etal., Circulation. 1996 Feb 1;93(3):440-9.
3. Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study. Carty CL, etal., Thromb Haemost. 2008 Feb;99(2):388-95.
4. Quantitative organellar proteomics analysis of rough endoplasmic reticulum from normal and acute pancreatitis rat pancreas. Chen X, etal., J Proteome Res. 2010 Feb 5;9(2):885-96.
5. Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the beta chain of human fibrinogen. Chung DW, etal., Biochemistry 1983 Jun 21;22(13):3244-50.
6. Cloning of the complete coding sequence of rat fibrinogen B beta chain cDNA: interspecies conservation of fibrin beta 15-42 primary structure. Courtney MA, etal., Blood Coagul Fibrinolysis 1994 Aug;5(4):487-96.
7. Cloning and characterization of a cDNA for the B beta chain of rat fibrinogen: evolutionary conservation of translated and 3'-untranslated sequences. Eastman EM and Gilula NB, Gene 1989 Jun 30;79(1):151-8.
8. Potential basis for regulation of the coordinately expressed fibrinogen genes: homology in the 5' flanking regions. Fowlkes DM, etal., Proc Natl Acad Sci U S A 1984 Apr;81(8):2313-6.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Epistatic effect of plasminogen activator inhibitor 1 and beta-fibrinogen genes on risk of glomerular microthrombosis in lupus nephritis: interaction with environmental/clinical factors. Gong R, etal., Arthritis Rheum. 2007 May;56(5):1608-17.
12. Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. Gralinski LE, etal., mBio. 2013 Aug 6;4(4). pii: mBio.00271-13. doi: 10.1128/mBio.00271-13.
13. Leptin induces inflammation-related genes in RINm5F insulinoma cells. Hekerman P, etal., BMC Mol Biol. 2007 May 23;8:41.
14. [Clinical and genetic analysis of 8 Chinese pedigrees with inherited dysfibrinogenemia]. Jiang M, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2014 Apr;31(2):134-9. doi: 10.3760/cma.j.issn.1003-9406.2014.02.002.
15. Haemostatic abnormalities persist despite glycaemic improvement by insulin therapy in lean type 2 diabetic patients. Knobl P, etal., Thromb Haemost. 1994 Jun;71(6):692-7.
16. Fibrinogen beta-derived Bbeta(15-42) peptide protects against kidney ischemia/reperfusion injury. Krishnamoorthy A, etal., Blood. 2011 Aug 18;118(7):1934-42. Epub 2011 Jun 17.
17. Identification of genes enhanced by protein-calorie malnutrition by differential display polymerase chain reaction (expression of fibrinogen B beta chain, B cell translocation gene 1 and thyroid hormone responsive protein genes). Lee AK, etal., Mol Cell Biochem 2002 Feb;231(1-2):163-71.
18. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
19. [The inherited procoagulant and prothrombotic condition as the main etiological factor for ischemic stroke in infants]. Lvova OA, etal., Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(9 Pt 2):13-20.
20. Antihypertensive pharmacogenetic effect of fibrinogen-beta variant -455G>A on cardiovascular disease, end-stage renal disease, and mortality: the GenHAT study. Lynch AI, etal., Pharmacogenet Genomics. 2009 Jun;19(6):415-21.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Fibrinogen and fibrin structure and functions. Mosesson MW J Thromb Haemost. 2005 Aug;3(8):1894-904.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Prenatal diagnosis for congenital afibrinogenemia caused by a novel nonsense mutation in the FGB gene in a Palestinian family. Neerman-Arbez M, etal., Blood. 2003 May 1;101(9):3492-4. Epub 2003 Jan 2.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Comprehensive gene review and curation RGD comprehensive gene curation
32. Beta-fibrinogen gene polymorphism (C148-->T) is associated with carotid atherosclerosis: results of the Austrian Stroke Prevention Study. Schmidt H, etal., Arterioscler Thromb Vasc Biol. 1998 Mar;18(3):487-92.
33. Molecular cloning of mRNA sequences transiently induced during rat liver regeneration. Sobczak J, etal., Exp Cell Res 1987 Mar;169(1):47-56.
34. Congenital afibrinogenemia: first identification of splicing mutations in the fibrinogen Bbeta-chain gene causing activation of cryptic splice sites. Spena S, etal., Blood 2002 Dec 15;100(13):4478-84. Epub 2002 Aug 1.
35. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
36. Proteomics of microparticles after experimental pulmonary embolism. Watts JA, etal., Thromb Res. 2011 Oct 17.
37. Bcl I polymorphism in the fibrinogen beta-chain gene is associated with the risk of familial myocardial infarction by increasing plasma fibrinogen levels. A case-control study in a sample of GISSI-2 patients. Zito F, etal., Arterioscler Thromb Vasc Biol. 1997 Dec;17(12):3489-94.
Additional References at PubMed
PMID:6281794   PMID:6777381   PMID:8100742   PMID:8910396   PMID:9182580   PMID:10903502   PMID:12477932   PMID:12706644   PMID:15489334   PMID:15739255   PMID:15914557   PMID:16452087  
PMID:16502470   PMID:16846481   PMID:17505302   PMID:18676163   PMID:19193866   PMID:19996109   PMID:22340239   PMID:22516433   PMID:22966213   PMID:23376485   PMID:23533145   PMID:24367264  
PMID:24769233  


Genomics

Comparative Map Data
Fgb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22168,394,901 - 168,402,863 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2168,394,916 - 168,405,979 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2175,586,120 - 175,593,059 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02173,607,044 - 173,613,983 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02168,208,465 - 168,215,404 (-)NCBIRnor_WKY
Rnor_6.02182,028,044 - 182,035,026 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,027,115 - 182,038,178 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02201,442,664 - 201,449,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42174,768,193 - 174,775,102 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12174,718,265 - 174,725,209 (-)NCBI
Celera2162,422,542 - 162,429,467 (-)NCBICelera
Cytogenetic Map2q34NCBI
FGB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384154,562,980 - 154,572,807 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4154,563,011 - 154,572,807 (+)EnsemblGRCh38hg38GRCh38
GRCh374155,484,132 - 155,493,959 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364155,703,596 - 155,711,688 (+)NCBINCBI36Build 36hg18NCBI36
Build 344155,841,767 - 155,849,841NCBI
Celera4152,815,112 - 152,824,894 (+)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4151,224,828 - 151,234,610 (+)NCBIHuRef
CHM1_14155,462,053 - 155,471,836 (+)NCBICHM1_1
T2T-CHM13v2.04157,894,764 - 157,904,590 (+)NCBIT2T-CHM13v2.0
Fgb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,949,553 - 82,957,170 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl382,947,448 - 82,957,170 (-)EnsemblGRCm39 Ensembl
GRCm38383,042,246 - 83,049,863 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,040,141 - 83,049,863 (-)EnsemblGRCm38mm10GRCm38
MGSCv37382,846,225 - 82,853,712 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,128,230 - 83,135,717 (-)NCBIMGSCv36mm8
Celera383,046,408 - 83,053,935 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.98NCBI
Fgb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554718,822,965 - 8,832,884 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,824,901 - 8,832,836 (-)NCBIChiLan1.0ChiLan1.0
FGB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14158,747,659 - 158,755,766 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4158,747,659 - 158,755,766 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04146,929,561 - 146,937,665 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FGB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11552,220,690 - 52,228,526 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1552,220,611 - 52,228,250 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1552,565,222 - 52,573,066 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01552,907,656 - 52,915,500 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1552,907,681 - 52,915,468 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11552,162,583 - 52,170,431 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01552,267,207 - 52,275,052 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01552,581,569 - 52,589,416 (+)NCBIUU_Cfam_GSD_1.0
Fgb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,233,115 - 38,240,864 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365761,306,109 - 1,313,386 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365761,306,076 - 1,313,485 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl874,595,688 - 74,607,409 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1874,598,170 - 74,607,409 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2878,952,697 - 78,961,938 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17101,106,468 - 101,114,566 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7101,106,483 - 101,114,662 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603780,761,750 - 80,769,888 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248585,864,784 - 5,874,869 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248585,866,104 - 5,874,173 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fgb
65 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:105
Count of miRNA genes:89
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000009813, ENSRNOT00000040708
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat

Markers in Region
D18026  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22168,395,843 - 168,395,968 (+)MAPPERmRatBN7.2
Rnor_6.02182,028,043 - 182,028,167NCBIRnor6.0
Rnor_5.02201,442,663 - 201,442,787UniSTSRnor5.0
RGSC_v3.42174,768,120 - 174,768,244UniSTSRGSC3.4
Celera2162,422,469 - 162,422,593UniSTS
Cytogenetic Map2q31-q34UniSTS
RH143374  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22168,396,132 - 168,396,452 (+)MAPPERmRatBN7.2
Rnor_6.02182,028,332 - 182,028,651NCBIRnor6.0
Rnor_5.02201,442,952 - 201,443,271UniSTSRnor5.0
RGSC_v3.42174,768,409 - 174,768,728UniSTSRGSC3.4
Celera2162,422,758 - 162,423,077UniSTS
RH 3.4 Map21096.0UniSTS
Cytogenetic Map2q31-q34UniSTS
RH140977  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22168,395,843 - 168,396,049 (+)MAPPERmRatBN7.2
Rnor_6.02182,028,043 - 182,028,248NCBIRnor6.0
Rnor_5.02201,442,663 - 201,442,868UniSTSRnor5.0
RGSC_v3.42174,768,120 - 174,768,325UniSTSRGSC3.4
Celera2162,422,469 - 162,422,674UniSTS
RH 3.4 Map21093.5UniSTS
Cytogenetic Map2q31-q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 35 35 29
Medium 14 12 12 9 2 2
Low 7 14 16 8 8 13 26 26 6 8
Below cutoff 2 11 2 1 22 9

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_020071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY321323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K01336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M35602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U05675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000009813   ⟹   ENSRNOP00000009813
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2168,395,884 - 168,402,849 (-)Ensembl
Rnor_6.0 Ensembl2182,028,113 - 182,035,032 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000040708   ⟹   ENSRNOP00000050663
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2168,394,916 - 168,405,979 (-)Ensembl
Rnor_6.0 Ensembl2182,027,115 - 182,038,178 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077663
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2182,034,288 - 182,035,033 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091155
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2182,031,610 - 182,035,032 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106331   ⟹   ENSRNOP00000087980
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2168,395,884 - 168,400,800 (-)Ensembl
RefSeq Acc Id: NM_020071   ⟹   NP_064456
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22168,395,917 - 168,402,826 (-)NCBI
Rnor_6.02182,028,116 - 182,035,025 (-)NCBI
Rnor_5.02201,442,664 - 201,449,657 (-)NCBI
RGSC_v3.42174,768,193 - 174,775,102 (-)RGD
Celera2162,422,542 - 162,429,467 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101711   ⟹   XP_038957639
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22168,394,901 - 168,402,863 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_064456   ⟸   NM_020071
- Peptide Label: precursor
- UniProtKB: Q7TME5 (UniProtKB/Swiss-Prot),   P14480 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009813   ⟸   ENSRNOT00000009813
RefSeq Acc Id: ENSRNOP00000050663   ⟸   ENSRNOT00000040708
RefSeq Acc Id: XP_038957639   ⟸   XM_039101711
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000087980   ⟸   ENSRNOT00000106331
Protein Domains
Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14480-F1-model_v2 AlphaFold P14480 1-479 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691397
Promoter ID:EPDNEW_R1922
Type:multiple initiation site
Name:Fgb_1
Description:fibrinogen beta chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02182,035,032 - 182,035,092EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2604 AgrOrtholog
BioCyc Gene G2FUF-52661 BioCyc
Ensembl Genes ENSRNOG00000007092 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009813 ENTREZGENE
  ENSRNOP00000009813.3 UniProtKB/TrEMBL
  ENSRNOP00000050663 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000087980.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009813 ENTREZGENE
  ENSRNOT00000009813.4 UniProtKB/TrEMBL
  ENSRNOT00000040708 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000106331.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.215.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7371665 IMAGE-MGC_LOAD
InterPro Fibrinogen-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_coil_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24366 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108554 IMAGE-MGC_LOAD
NCBI Gene 24366 ENTREZGENE
PANTHER PTHR19143:SF332 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Fib_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB FGB RGD
PhenoGen Fgb PhenoGen
PROSITE FIBRINOGEN_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIBRINOGEN_C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FBG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fib_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56496 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A9U0_RAT UniProtKB/TrEMBL
  A0A8L2UIC0_RAT UniProtKB/TrEMBL
  FIBB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TME5 ENTREZGENE
UniProt Secondary Q5I0P7 UniProtKB/Swiss-Prot
  Q7TME5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-17 Fgb  fibrinogen beta chain  Fgb  fibrinogen, B beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Fgb  fibrinogen, B beta polypeptide    fibrinogen, beta polypeptide  Name updated 1299863 APPROVED
2002-06-10 Fgb  Fibrinogen, B beta polypeptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression maybe induced during hepatocyte regeneration after liver damage 70249