WARFARIN PHARMACODYNAMICS PATHWAY (PW:0000731)

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Description

Warfarin, trade name Coumadin, is a widely used oral anticoagulant drug for the prevention of thrombosis and venous and arterial thromboembolism. It is a synthetic derivative of coumarin-derived dicoumarol. Warfarin is present as a racemic mixture of R and S enantiomers, both active, though not equally, and both metabolized via different routes. Warfarin is metabolized by several cytochrome P450 phase I biotransformation enzymes, depending on the enantiomeric form and producing a number of metab

Pathway Diagram:

Elsevier Inc. Vkorc1 warfarin warfarin ---| Thromboembolism warfarin ---| Thrombosis Vkorc1 ---- warfarin vitamin K cycle pathway warfarin ---| vitamin K cycle pathway warfarin ---| Vkorc1 coagulation cascade pathway warfarin ---| coagulation cascade pathway Thromboembolism Thrombosis
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Genes in Pathway:

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warfarin pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:10402751
G F10 coagulation factor X JBrowse link 16 81,803,169 81,822,476 RGD:10402751
G F11 coagulation factor XI JBrowse link 16 50,179,458 50,201,644 RGD:10402751
G F12 coagulation factor XII JBrowse link 17 9,736,577 9,744,420 RGD:10402751
G F13a1 coagulation factor XIII A1 chain JBrowse link 17 28,504,650 28,680,015 RGD:10402751
G F13b coagulation factor XIII B chain JBrowse link 13 56,598,891 56,623,132 RGD:10402751
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:10402751
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:10402751
G F5 coagulation factor V JBrowse link 13 82,479,997 82,535,540 RGD:10402751
G F7 coagulation factor VII JBrowse link 16 81,824,610 81,834,923 RGD:10402751
G F8 coagulation factor VIII JBrowse link 18 367,862 399,242 RGD:10402751
G F9 coagulation factor IX JBrowse link X 143,097,507 143,141,791 RGD:10402751
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:10402751
G Fgb fibrinogen beta chain JBrowse link 2 182,028,044 182,035,026 RGD:10402751
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:10402751
G Ggcx gamma-glutamyl carboxylase JBrowse link 4 100,277,345 100,293,097 RGD:10402751
G Klkb1 kallikrein B1 JBrowse link 16 50,151,127 50,175,407 RGD:10402751
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:10402751
G Plg plasminogen JBrowse link 1 48,521,828 48,563,895 RGD:10402751
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 JBrowse link 1 199,338,785 199,341,306 RGD:11354881
RGD:10402751

Pathway Gene Annotations

Disease Annotations Associated with Genes in the warfarin pharmacodynamics pathway
Disease TermsGene Symbols
Abortion, HabitualF5
Abortion, SpontaneousCol1a1 , F11 , F12 , F13a1 , F3
Acquired AngioedemaF12 , F2 , F7
Activated Protein C ResistanceF5
Acute Coronary SyndromeF12 , F2
acute kidney failureFga , Plat , Plg
Acute Liver FailureFga
Acute Lung InjuryF2 , F3 , Fga
acute myeloid leukemiaF3
acute pancreatitisF7
acute promyelocytic leukemiaF3 , Plat
Acute Traumatic CoagulopathyPlat
adult respiratory distress syndromeF3
aggressive periodontitisCol1a1
Airway ObstructionPlat
AlbuminuriaF7
alcoholic hepatitisCol1a1
allergic contact dermatitisF13a1 , Plat
allergic rhinitisF2
Alzheimer's diseaseF2
amphetamine abusePlat
Angina, StableF7
angioedemaF12 , Plat
Animal Disease ModelsF7
anterior ischemic optic neuropathyF5
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisF3
antiphospholipid syndromePlat
Aortic CalcificationVkorc1
Aortic RuptureVkorc1
aortic valve insufficiencyCol1a1
aphasiaPlat
appendicitisF2
Arterial Occlusive DiseasesPlat
Arterial ThrombosisF7 , Plat
arteriosclerosisF13a1 , F7
Arteriovenous FistulaCol1a1
asphyxia neonatorumCol1a1
asthmaF2 , F7 , Fga
atherosclerosisF2 , Plat
atopic dermatitisF2
autism spectrum disorderKlkb1
Autoimmune DiseasesCol1a1 , F8
autoimmune hepatitisF2
autoimmune thrombocytopenic purpuraPlat
autosomal recessive nonsyndromic deafness 7F12
Back PainPlat
BacteremiaPlat
bacterial pneumoniaF2
Behcet's diseaseF5
beta thalassemiaCol1a1
bile duct diseaseF3
bilirubin metabolic disorderF12 , F7
Bisphosphonate-Associated Osteonecrosis of the JawCol1a1
bladder neck obstructionCol1a1
blood coagulation diseaseF10 , F2 , F5 , Fga , Fgg , Ggcx , Plat , Vkorc1
bone development diseaseCol1a1
Bone FracturesCol1a1
brain edemaF2 , Plat
brain infarctionPlat
Brain InjuriesF2
brain ischemiaF2 , F5 , Fga , Plat
Breast NeoplasmsF10 , F3 , F5 , F7
Budd-Chiari syndromeF5
bullous pemphigoidF2
BurnsFga , Plat
Caffey diseaseCol1a1
calcinosisCol1a1
Cardiac Allograft VasculopathyF3
Cardiac FibrosisCol1a1 , F3
cardiac tamponadePlat
Cardiogenic ShockPlat
cardiovascular system diseaseFgb
carotid artery diseaseFgb
Carotid Artery InjuriesPlat
carotid artery thrombosisF3 , Klkb1
carotid stenosisF2
celiac diseaseF2
Central Nervous System Viral DiseasesPlat
Cerebral HemorrhageF13a1 , F2 , F7 , Plat
cerebral infarctionF2 , F5 , F7 , Plat
Cerebral Small Vessel DiseasesFga , Fgg
cerebrovascular diseaseF2 , F5
Chagas diseaseF2
Chemical and Drug Induced Liver InjuryF13a1 , F3 , Fga , Plat , Plg
cholangitisCol1a1
cholestasisCol1a1 , Fga
cholesterol embolismPlat
Choroidal NeovascularizationF7
Chronic Allograft DysfunctionF7
chronic obstructive pulmonary diseaseCol1a1 , F2
clear cell renal cell carcinomaF2
coagulation protein diseaseGgcx
Colonic NeoplasmsF5
Colorectal NeoplasmsF5 , F7
congenital afibrinogenemiaFga , Fgb , Fgg
congestive heart failurePlat
conjunctivitisPlg
ContractureCol1a1
ContusionsF2
coronary artery diseaseF2 , F7 , Fgb
Coronary DiseaseF12 , F13a1 , Vkorc1
coronary thrombosisPlat
Coumarin ResistanceF9 , Vkorc1
Coumarin SensitivityF9 , Vkorc1
Crohn's diseaseF13a1 , F2 , Fga
cutaneous leishmaniasisCol1a1
Cutaneous Malignant Melanoma, Susceptibility To, 1Plg
DeathF12
degenerative disc diseaseCol1a1
dentinogenesis imperfectaCol1a1
dermatofibrosarcoma protuberansCol1a1
diabetes mellitusF3 , F7
diabetic angiopathyF3 , Plat
Diabetic FootPlat
Diabetic NephropathiesCol1a1 , F2 , F3 , Klkb1 , Plat
diabetic neuropathyF7 , Plat
diabetic retinopathyF13a1 , F7
Dissecting AneurysmCol1a1
disseminated intravascular coagulationF13a1 , F2 , F3 , F7 , Fga , Plat
Drug-Related Side Effects and Adverse ReactionsFga , Plg , Vkorc1
DysarthriaF5
Dysfibrinogenemia, CongenitalFga , Fgb , Fgg
DyspneaF5
DysprothrombinemiaF2
Ehlers-Danlos syndromeCol1a1
Ehlers-Danlos Syndrome Classic TypeCol1a1
Ehlers-Danlos Syndrome, Type VII, Autosomal DominantCol1a1
EmbolismPlat
Embolism and ThrombosisF3 , Plat
end stage renal failureCol1a1 , F2 , F5 , Fgb
EndotoxemiaF12 , F2 , F3 , F5 , F7 , F8 , Fga , Plat
EnterocolitisKlkb1
Experimental ArthritisF2 , Klkb1
Experimental Diabetes MellitusF2 , F3 , F7 , Fga
Experimental Liver CirrhosisCol1a1 , F5 , Fgg , Plat , Plg
extrahepatic cholestasisCol1a1
Extrahepatic Portal Vein ObstructionF7
eye diseaseF2
factor V deficiencyF5
factor VII deficiencyF10 , F7
factor VIII deficiencyF2 , F8 , F9 , Plat
Factor VIII Deficiency, AcquiredF8
factor X deficiencyF10 , F7
factor XI deficiencyF11
factor XII deficiencyF12
factor XIII deficiencyF13a1 , F13b
Factor Xiii, A Subunit, Deficiency OfF13a1
Factor XIII, B Subunit, Deficiency OfF13b
familial adenomatous polyposisF5
Familial AmyloidosisFga
familial hyperlipidemiaF3 , F7
familial visceral amyloidosisFga
fatty liver diseaseF2
Femoral FracturesCol1a1
Femur Head NecrosisF2 , F5 , Plat
Fetal DeathF5
FibrosisCol1a1
Fractures, MultipleCol1a1
Fractures, SpontaneousCol1a1
gastric ulcerF13a1
genetic diseaseCol1a1 , F8 , F9 , Fgg
gestational diabetesPlat
Glandular and Epithelial NeoplasmsF7
glomerulonephritisF2 , Klkb1
Graft vs Host DiseaseF3
heart valve diseaseCol1a1
Hematoma, Epidural, SpinalPlat
Hematoma, SubduralPlat
Hematoma, Subdural, AcuteF7
HematuriaF7
hemolytic-uremic syndromePlat
hemophilia BF2 , F9
HemorrhageF10 , F13a1 , F2 , F3 , F7 , F8 , Plat , Vkorc1
hemorrhagic diseaseF7 , Ggcx
Henoch-Schoenlein purpuraPlat
Hepatitis, ChronicPlat
hepatocellular carcinomaF2
hereditary angioedemaF12 , F2 , F7
Hereditary Angioedema Type IIIF12
Hereditary ThrombophiliaF5
Hernia, VentralCol1a1
High MyopiaCol1a1
Huntington's diseaseF2
HyperalgesiaF2
hypereosinophilic syndromeF5
hyperglycemiaF2 , F7
hyperhomocysteinemiaF10 , F12 , F2 , F8
HypertelorismCol1a1
hypertensionCol1a1 , F11 , F12 , F3 , F7 , Klkb1 , Plat , Plg
Hypertensive NephropathyCol1a1
HypertriglyceridemiaF7
HypertrophyF2
Hypertrophy, Left VentricularCol1a1
Hypertrophy, Right VentricularPlat
Hypodysfibrinogenemia, CongenitalFga , Fgg
Hypophosphatemic Nephrolithiasis/OsteoporosisF12
Hypopituitarism and Septooptic 'Dysplasia'F9
HypotensionPlat
hypothyroidismF7
HypoxiaPlat
Hypoxia-Ischemia, BrainPlat
idiopathic pulmonary fibrosisF3
InflammationF3 , Fgg
inflammatory bowel diseaseKlkb1
inherited blood coagulation diseaseF7 , Ggcx
Insulin ResistanceF7
intermediate coronary syndromeF7
Intervertebral Disc DiseaseCol1a1
Intestinal Reperfusion InjuryF7
Intracranial Embolism and ThrombosisPlat
Intracranial Hemorrhage, TraumaticF7
Intracranial HemorrhagesF7 , Plat
intracranial sinus thrombosisF2
intracranial thrombosisPlat
intracranial vasospasmPlat
Joint InstabilityCol1a1
KeloidCol1a1 , Fgg
keratoconusFga
Kidney CalculiF2
kidney diseaseF7 , Fga
Kidney Reperfusion InjuryF3 , Fga , Fgb , Fgg
lactic acidosisPlat
lattice corneal dystrophyF10 , F2
leukopeniaPlat
LipodermatosclerosisCol1a1
Lipoyltransferase 1 DeficiencyF9
liver cirrhosisCol1a1 , F2 , F3 , F5 , Klkb1
Liver FailureF2
Liver InjuryFgg
liver neoplasmCol1a1
Liver Neoplasms, ExperimentalF12
Liver Reperfusion InjuryF3 , Fga
Low Back PainPlat
lupus nephritisCol1a1 , Klkb1
malignant gliomaF2
malignant mesotheliomaF9
melanomaPlg
membranoproliferative glomerulonephritisF5
membranous glomerulonephritisPlg
meningoencephalitisPlat
Mesenteric IschemiaF2 , F5
Metabolic Bone DiseasesCol1a1
Metabolic SyndromeF3 , Plat
middle cerebral artery infarctionF11 , F12 , Plat
Mouth NeoplasmsFga
multiple myelomaFgg
Multiple Organ FailurePlat
multiple sclerosisCol1a1
Muscle HypotoniaCol1a1
myeloid neoplasmF3
myocardial infarctionCol1a1 , F10 , F12 , F13a1 , F2 , F3 , F5 , F7 , Fgb , Plat
Myocardial IschemiaF3 , F5
myocarditisCol1a1
myopiaCol1a1
NeointimaF3
Neoplasm MetastasisF2
Nephrogenic Fibrosing DermopathyCol1a1
Nephrolithiasis, Calcium OxalateF2
nephrosisF2
nephrotic syndromeCol1a1 , F3
Nerve DegenerationF2 , Plat
neuronal ceroid lipofuscinosis 8F9
nonalcoholic fatty liver diseaseCol1a1 , F2
Noonan syndromeF11 , Plat , Plg
obesityF2 , F7 , Fgg , Plat
ocular hypertensionCol1a1
OI/EDS Combined SyndromeCol1a1
open-angle glaucomaCol1a1
oral submucous fibrosisCol1a1
osteoarthritisCol1a1
Osteoarthritis, ExperimentalCol1a1
Osteoarthritis, HipCol1a1
Osteoarthritis, KneeF2
osteogenesis imperfectaCol1a1
osteogenesis imperfecta type 1Col1a1
osteogenesis imperfecta type 2Col1a1
osteogenesis imperfecta type 3Col1a1
osteogenesis imperfecta type 4Col1a1
Osteogenesis Imperfecta, Type 2CCol1a1
Osteopenic Nonfracture SyndromeCol1a1
osteoporosisCol1a1 , Fga , Fgb
otosclerosisCol1a1
ovarian hyperstimulation syndromeF3
Ovarian NeoplasmsF2 , F7
Ovary Reperfusion InjuryF3
pancreatic adenocarcinomaPlat
pancreatitisFga , Fgb , Fgg
Pancreatitis, ChronicCol1a1
ParatuberculosisF2
ParesisPlat
Parkinson's diseaseFgb
Pediatric Crohn's DiseaseF2
pericardial effusionPlat
Peritoneal FibrosisF10 , F3 , F5
peritonitisPlat
Plasminogen Deficiency, Type IPlg
Postoperative ComplicationsF7
pre-eclampsiaF2 , F3 , F5
precursor B lymphoblastic lymphoma/leukemiaF13a1 , F3
precursor lymphoblastic lymphoma/leukemiaF3 , Fga
PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITY TO, 1F5
PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITY TO, 2F2
Prekallikrein DeficiencyKlkb1
Premature BirthCol1a1
Prenatal Cortical Hyperostosis, LethalCol1a1
preterm premature rupture of the membranesF3
primary biliary cirrhosisCol1a1
prostate cancerCol1a1 , F2 , F5
proteinuriaF7
prothrombin deficiencyF2 , F7
Prothrombin Deficiency, CongenitalF2
Pseudoxanthoma Elasticum-Like Disorder with Multiple Coagulation Factor DeficiencyGgcx
pulmonary embolismF13a1 , F2 , F5 , Fga , Fgb , Fgg , Klkb1 , Plat
pulmonary emphysemaFga
pulmonary fibrosisCol1a1 , F2 , F5
pulmonary hypertensionCol1a1 , F5
Reperfusion InjuryF2 , Plat
respiratory failurePlat
retinal artery occlusionF5
retinal vein occlusionF2 , F5
rheumatoid arthritisF2
sagittal sinus thrombosisF5
schizophreniaF2
sciatic neuropathyPlat
Seasonal Allergic RhinitisFga
sensorineural hearing lossF2 , F5
SepsisF11 , F2 , F3 , F5 , F7 , F9 , Fga , Klkb1 , Plat
Septic PeritonitisF5
Shock, HemorrhagicF2 , F8
sickle cell anemiaF13a1 , F2 , F3
Smith-Magenis syndromeCol1a1
Smoke Inhalation InjuryF7
Snake BitesF3
Spinal Cord CompressionPlat
Spinal Cord InjuriesF2
status epilepticusPlat
Stomach NeoplasmsFgg
StrokeF12 , F13a1 , F2 , F5 , F8 , Fga , Fgb , Fgg , Plat , Vkorc1
Systemic Inflammatory Response SyndromeF3
systemic lupus erythematosusF2 , Klkb1
systemic sclerodermaCol1a1 , F2
Tendon InjuriesCol1a1
thoracic aortic aneurysmCol1a1
thrombocytopeniaF7 , Fga
ThromboembolismF12 , F2 , F3 , F5 , F7 , F8 , Plat
thrombophiliaF13a1 , F2 , F3 , F5 , F8 , Fga , Plg
Thrombophilia, Familial, due to Decreased Release of Tissue Plasminogen ActivatorPlat
thrombosisF10 , F11 , F2 , F3 , F5 , F9 , Fga , Fgb , Klkb1 , Plat
Thrombotic MicroangiopathiesF3 , Fgg
thrombotic thrombocytopenic purpuraF3
toxic encephalopathyPlat
Trachomatous TrichiasisCol1a1
transient cerebral ischemiaF12 , Plat
Transplant RejectionPlat
type 1 diabetes mellitusF7 , Plat
type 2 diabetes mellitusF12 , F2 , F3 , F7 , F8 , F9 , Fga , Fgb , Fgg , Plat
type I Ehlers-Danlos syndromeCol1a1
type II Ehlers-Danlos SyndromeCol1a1
ulcerative colitisCol1a1 , F2
ureteral obstructionCol1a1
urinary bladder cancerF2
Urinary CalculiF2
UrolithiasisGgcx
urticariaF12 , F2
Uterine HemorrhageF13a1
vascular diseaseVkorc1
vascular skin diseaseF2
Venous ThromboembolismF2 , F5 , Fga , Plat
Venous ThrombosisF11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , Fga , Plat , Plg
Ventricular Dysfunction, LeftF2 , Plat
Ventricular FibrillationF2
Viral Hepatitis, HumanCol1a1 , F2
Viral MyocarditisF3
Vitamin K Deficiency BleedingGgcx
Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 1Ggcx
Vitamin K-Dependent Clotting Factors, Combined Deficiency of, 2Vkorc1
von Willebrand's diseaseF3
von Willebrand's disease 1Plat
von Willebrand's disease 2F8
Warfarin SensitivityF9 , Vkorc1
Wounds and InjuriesPlat
X-Linked Thrombophilia, due to Factor IX DefectF9
Pathway Annotations Associated with Genes in the warfarin pharmacodynamics pathway
Pathway TermsGene Symbols
acenocoumarol pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
alteplase pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
aminocaproic acid pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
anistreplase pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
aprotinin pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
argatroban pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
bivalirudin pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
cell-extracellular matrix signaling pathwayCol1a1
coagulation cascade pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
complement system pathwayF10 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
dicoumarol pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
enoxaparin pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
Entamoebiasis pathwayCol1a1
ephrin - ephrin receptor bidirectional signaling axisFga , Fgb , Fgg
fibrinolysis pathwayFga , Fgb , Fgg , Plat , Plg
fondaparinux pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
forkhead class A signaling pathwayF2
heparin pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
influenza A pathwayPlg
interleukin-4 signaling pathwayCol1a1
interleukin-6 signaling pathwayFgg
kallikrein-kinin cascade pathwayF12 , Klkb1
phenindione pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
protease mediated signaling via protease-activated receptor 1F2
protease mediated signaling via protease-activated receptor 2F10
protease mediated signaling via protease-activated receptor 3F2
protease mediated signaling via protease-activated receptor 4F2
protein C anticoagulant pathwayF2 , F5
reteplase pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
Staphylococcus aureus infection pathwayFgg , Plg
syndecan signaling pathwayCol1a1 , F2 , Plg
tranexamic acid pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
vitamin K cycle pathwayGgcx , Vkorc1
vitamin K metabolic pathwayF2 , Ggcx , Vkorc1
warfarin pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
Phenotype Annotations Associated with Genes in the warfarin pharmacodynamics pathway

References Associated with the warfarin pharmacodynamics pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: