WARFARIN PHARMACODYNAMICS PATHWAY (PW:0000731)

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Description

Warfarin, trade name Coumadin, is a widely used oral anticoagulant drug for the prevention of thrombosis and venous and arterial thromboembolism. It is a synthetic derivative of coumarin-derived dicoumarol. Warfarin is present as a racemic mixture of R and S enantiomers, both active, though not equally, and both metabolized via different routes. Warfarin is metabolized by several cytochrome P450 phase I biotransformation enzymes, depending on the enantiomeric form and producing a number of metab

Pathway Diagram:

Elsevier Inc. Vkorc1 warfarin warfarin ---| Thromboembolism warfarin ---| Thrombosis Vkorc1 ---- warfarin vitamin K cycle pathway warfarin ---| vitamin K cycle pathway warfarin ---| Vkorc1 coagulation cascade pathway warfarin ---| coagulation cascade pathway Thromboembolism Thrombosis
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Genes in Pathway:

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warfarin pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:10402751
G F10 coagulation factor X JBrowse link 16 81,803,169 81,822,476 RGD:10402751
G F11 coagulation factor XI JBrowse link 16 50,179,458 50,201,644 RGD:10402751
G F12 coagulation factor XII JBrowse link 17 9,736,577 9,744,420 RGD:10402751
G F13a1 coagulation factor XIII A1 chain JBrowse link 17 28,504,650 28,680,015 RGD:10402751
G F13b coagulation factor XIII B chain JBrowse link 13 56,598,891 56,623,132 RGD:10402751
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:10402751
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:10402751
G F5 coagulation factor V JBrowse link 13 82,479,997 82,535,540 RGD:10402751
G F7 coagulation factor VII JBrowse link 16 81,824,610 81,834,923 RGD:10402751
G F8 coagulation factor VIII JBrowse link 18 367,862 399,242 RGD:10402751
G F9 coagulation factor IX JBrowse link X 143,097,507 143,141,791 RGD:10402751
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:10402751
G Fgb fibrinogen beta chain JBrowse link 2 182,028,044 182,035,026 RGD:10402751
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:10402751
G Ggcx gamma-glutamyl carboxylase JBrowse link 4 100,277,345 100,293,097 RGD:10402751
G Klkb1 kallikrein B1 JBrowse link 16 50,151,127 50,175,407 RGD:10402751
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:10402751
G Plg plasminogen JBrowse link 1 48,521,828 48,563,895 RGD:10402751
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 JBrowse link 1 199,338,785 199,341,306 RGD:10402751
RGD:11354881

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the warfarin pharmacodynamics pathway
Pathway TermsGene Symbols
acenocoumarol pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
alteplase pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
aminocaproic acid pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
anistreplase pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
aprotinin pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
argatroban pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
bivalirudin pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
cell-extracellular matrix signaling pathwayCol1a1
coagulation cascade pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
complement system pathwayF10 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
dicoumarol pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
enoxaparin pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
Entamoeba histolyca infection pathwayCol1a1
ephrin - ephrin receptor bidirectional signaling axisFga , Fgb , Fgg
fibrinolysis pathwayFga , Fgb , Fgg , Plat , Plg
fondaparinux pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
forkhead class A signaling pathwayF2
heparin pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
influenza A virus infection pathwayPlg
interleukin-4 signaling pathwayCol1a1
interleukin-6 signaling pathwayFgg
kallikrein-kinin cascade pathwayF12 , Klkb1
phenindione pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
protease mediated signaling via protease-activated receptor 1F2
protease mediated signaling via protease-activated receptor 2F10
protease mediated signaling via protease-activated receptor 3F2
protease mediated signaling via protease-activated receptor 4F2
protein C anticoagulant pathwayF2 , F5
reteplase pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
Staphylococcus aureus infection pathwayFgg , Plg
syndecan signaling pathwayCol1a1 , F2 , Plg
tranexamic acid pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1
vitamin K cycle pathwayGgcx , Vkorc1
vitamin K metabolic pathwayF2 , Ggcx , Vkorc1
warfarin pharmacodynamics pathwayCol1a1 , F10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Ggcx , Klkb1 , Plat , Plg , Vkorc1

References Associated with the warfarin pharmacodynamics pathway:

Ontology Path Diagram:

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