COAGULATION CASCADE PATHWAY (PW:0000474)

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Description

In response to vascular injury, the hemostatic system triggers platelet aggregation and initiation of the coagulation cascade, primary and secondary hemostasis, respectively, to prevent bleeding. The coagulation cascade, initiated via tissue factor - the extrinsic pathway, or contact - the intrinsic pathway, converges into a common pathway leading to formation of insoluble fibrin clots. Sequential activation of zymogens (inert enzyme precursors) and cofactors through limited proteolysis yields t

Pathway Diagram:

Elsevier Inc. Serpinc1 ---| F9a Proc_act_diss pF13a F10a F5a F8a F9a vitamin K-dependent proteins, coagulation F7a F7 Proz ---- Serpina10 tenase complex extrinsic tenase complex Klkb1 --+> F12a F12a --+> Klkb1 protein C anticoagulant pathway Serpina10 ---| F10a Proc_act_diss ---| F5a Proc_act_diss ---| F8a F10 ---- TF/F7a complex extrinsic tenase complex --+> F10a F2a ---> protease mediated signaling pathway F10a ---> protease mediated signaling pathway prothrombinase complex --+> F2a F12 tenase complex ---> F10 F12a --+> F11a F12a ---> F11 F3 ---- F7a F11a ---> F9 F11a --+> F9a Vwf F8 F9a ---> F8 F7 --+> F7a F8 ---- Vwf F12 --+> F12a prothrombinase complex ---> F2 fibrin polymerization, cross-linking --+> fibrinolysis pathway Serping1 ---| F12a Serping1 ---| F11a TF/F7a complex TF/F7a complex --+> F9a F2a --+> fibrin pF13 --+> pF13a pKlkb1 Klkb1 Serping1 ---| Klkb1 F2a ---> fibrinogen F5 --+> F5a Tfpi ---| extrinsic tenase complex fibrinolysis pathway ---> fibrin pF13a --+> fibrin polymerization, cross-linking F10 F2 F5 tenase complex --+> F10a Serpinc1 ---| F2a Serpinc1 ---| F10a protease mediated signaling pathway F11 F9a --+> F8a F9 prothrombinase complex F2a pF13 fibrin fibrinogen fibrin polymerization, cross-linking vitamin K cycle pathway kallikrein-kinin cascade pathway F3 Proz Serpina10 Serpinc1 Tfpi Serping1 F12a F11a fibrinolysis pathway
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Genes in Pathway:

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coagulation cascade pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:6907045
G Apoh apolipoprotein H JBrowse link 10 96,640,013 96,653,939 RGD:1578489
G Bdkrb1 bradykinin receptor B1 JBrowse link 6 129,437,423 129,441,553 RGD:6907045
G Bdkrb2 bradykinin receptor B2 JBrowse link 6 129,399,468 129,429,676 RGD:6907045
G C1qa complement C1q A chain JBrowse link 5 155,261,254 155,264,101 RGD:6907045
G C1qb complement C1q B chain JBrowse link 5 155,246,444 155,251,995 RGD:6907045
G C1qc complement C1q C chain JBrowse link 5 155,255,013 155,258,631 RGD:6907045
G C1r complement C1r JBrowse link 4 157,126,060 157,136,825 RGD:6907045
G C1s complement C1s JBrowse link 4 157,143,592 157,155,592 RGD:6907045
G C2 complement C2 JBrowse link 20 4,542,340 4,561,152 RGD:6907045
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:6907045
G C3ar1 complement C3a receptor 1 JBrowse link 4 155,681,767 155,691,240 RGD:6907045
G C4b complement C4B (Chido blood group) JBrowse link 20 4,302,344 4,316,752 RGD:6907045
G C4bpa complement component 4 binding protein, alpha JBrowse link 13 47,342,090 47,377,580 RGD:6907045
G C4bpb complement component 4 binding protein, beta JBrowse link 13 47,387,173 47,398,115 RGD:6907045
G C5 complement C5 JBrowse link 3
3
14,049,993
14,206,466
14,113,931
14,229,141
RGD:6907045
G C5ar1 complement C5a receptor 1 JBrowse link 1 78,186,777 78,195,132 RGD:6907045
G C6 complement C6 JBrowse link 2 54,460,333 54,533,801 RGD:6907045
G C7 complement C7 JBrowse link 2 54,707,621 54,781,624 RGD:6907045
G C8a complement C8 alpha chain JBrowse link 5 124,348,536 124,403,117 RGD:6907045
G C8b complement C8 beta chain JBrowse link 5 124,298,269 124,338,055 RGD:6907045
G C8g complement C8 gamma chain JBrowse link 3 2,724,616 2,727,616 RGD:6907045
G C9 complement C9 JBrowse link 2 55,775,562 55,823,807 RGD:6907045
G Cd46 CD46 molecule JBrowse link 13 113,786,525 113,818,741 RGD:6907045
G Cd55 CD55 molecule JBrowse link 13 47,125,156 47,153,557 RGD:6907045
G Cd59 CD59 molecule JBrowse link 3 94,010,481 94,028,660 RGD:6907045
G Cfb complement factor B JBrowse link 20 4,536,206 4,542,073 RGD:6907045
G Cfd complement factor D JBrowse link 7 12,634,216 12,635,939 RGD:6907045
G Cfh complement factor H JBrowse link 13 56,979,155 57,080,540 RGD:6907045
G Cfi complement factor I JBrowse link 2 235,264,149 235,305,779 RGD:6907045
G Cpb2 carboxypeptidase B2 JBrowse link 15 57,290,849 57,339,762 RGD:6907045
G Cr1l complement C3b/C4b receptor 1 like JBrowse link 13 113,824,886 113,872,097 RGD:6907045
G Cr2 complement C3d receptor 2 JBrowse link 13 113,890,274 113,927,824 RGD:6907045
G F10 coagulation factor X JBrowse link 16 81,803,169 81,822,476 RGD:1580376
RGD:11352277
RGD:11342779
RGD:6907045
RGD:2290183
G F11 coagulation factor XI JBrowse link 16 50,179,458 50,201,644 RGD:2290183
RGD:11352277
RGD:11342779
G F12 coagulation factor XII JBrowse link 17 9,736,577 9,744,420 RGD:2290183
RGD:11352277
RGD:11342779
RGD:6907045
G F13a1 coagulation factor XIII A1 chain JBrowse link 17 28,504,650 28,680,015 RGD:6907045
RGD:11352259
G F13b coagulation factor XIII B chain JBrowse link 13 56,598,891 56,623,132 RGD:6907045
RGD:11352259
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:1578509
RGD:11352277
RGD:11342779
RGD:6907045
RGD:2290183
G F2r coagulation factor II (thrombin) receptor JBrowse link 2 26,118,760 26,135,340 RGD:6907045
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6907045
RGD:11352277
RGD:11342779
G F5 coagulation factor V JBrowse link 13 82,479,997 82,535,540 RGD:1580372
RGD:11352277
RGD:11342779
RGD:2290183
RGD:6907045
G F7 coagulation factor VII JBrowse link 16 81,824,610 81,834,923 RGD:1580376
RGD:11352277
RGD:11342779
RGD:6907045
RGD:2290183
G F8 coagulation factor VIII JBrowse link 18 367,862 399,242 RGD:1582368
RGD:11352277
RGD:11342779
RGD:6907045
RGD:2290183
G F9 coagulation factor IX JBrowse link X 143,097,507 143,141,791 RGD:1580376
RGD:11352277
RGD:11342779
RGD:6907045
RGD:2290183
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:6907045
RGD:11352259
G Fgb fibrinogen beta chain JBrowse link 2 182,028,044 182,035,026 RGD:6907045
RGD:11352259
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:6907045
RGD:11352259
G Klkb1 kallikrein B1 JBrowse link 16 50,151,127 50,175,407 RGD:6907045
G Kng2 kininogen 2 JBrowse link 11 81,509,185 81,516,759 RGD:6907045
G Kng2l1 kininogen 2-like 1 RGD:6907045
G Masp1 mannan-binding lectin serine peptidase 1 JBrowse link 11 80,736,424 80,806,278 RGD:6907045
G Masp2 mannan-binding lectin serine peptidase 2 JBrowse link 5 165,415,105 165,429,857 RGD:6907045
G Mbl1 mannose-binding lectin (protein A) 1 JBrowse link 16 18,736,154 18,742,193 RGD:6907045
G Mbl2 mannose binding lectin 2 JBrowse link 1 248,435,069 248,442,669 RGD:6907045
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:6907045
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:6907045
G Plaur plasminogen activator, urokinase receptor JBrowse link 1 81,328,171 81,344,954 RGD:6907045
G Plg plasminogen JBrowse link 1 48,521,828 48,563,895 RGD:6907045
G Proc protein C, inactivator of coagulation factors Va and VIIIa JBrowse link 18 24,918,402 24,928,822 RGD:6907045
RGD:11352277
G Pros1 protein S JBrowse link 7 1,206,648 1,288,140 RGD:6907045
G Proz protein Z, vitamin K-dependent plasma glycoprotein JBrowse link 16 81,784,348 81,797,889 RGD:11352284
G Serpina1 serpin family A member 1 JBrowse link 6 127,610,241 127,632,265 RGD:6907045
G Serpina10 serpin family A member 10 JBrowse link 6 127,500,014 127,508,470 RGD:11352284
G Serpina5 serpin family A member 5 JBrowse link 6 127,753,152 127,772,403 RGD:6907045
G Serpinc1 serpin family C member 1 JBrowse link 13 78,806,107 78,820,375 RGD:6907045
RGD:11352277
G Serpind1 serpin family D member 1 JBrowse link 11 87,913,814 87,924,880 RGD:6907045
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6907045
G Serpinf2 serpin family F member 2 JBrowse link 10 62,264,247 62,272,353 RGD:6907045
G Serping1 serpin family G member 1 JBrowse link 3 72,161,230 72,171,109 RGD:6907045
RGD:11352277
RGD:11342779
G Tfpi tissue factor pathway inhibitor JBrowse link 3 71,852,738 71,902,127 RGD:6907045
RGD:11352277
RGD:11342779
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:6907045
G Vwf von Willebrand factor JBrowse link 4 158,085,059 158,219,525 RGD:6907045

Pathway Gene Annotations

Disease Annotations Associated with Genes in the coagulation cascade pathway
Disease TermsGene Symbols
3MC syndrome 1Kng2 , Masp1
3MC syndrome 2Masp1
3MC syndrome 3Masp1
abdominal aortic aneurysmSerpine1
Abortion, HabitualF5 , Thbd
Abortion, SpontaneousF11 , F12 , F13a1 , F3 , Mbl2
Acquired AngioedemaF12 , F2 , F7 , Kng2 , Serping1
Acquired Protein C DeficiencySerpine1
Activated Protein C ResistanceF5 , Proc , Pros1 , Tfpi
Acute Coronary SyndromeF12 , F2 , Serpinc1
acute kidney failureA2m , Bdkrb2 , C3 , Fga , Kng2 , Plat , Plg , Proc , Serpina1 , Serpinc1 , Thbd
Acute Liver FailureFga , Serpinc1 , Thbd
Acute Lung InjuryC3 , F2 , F3 , Fga , Plau , Proc , Serpinc1 , Serpine1 , Serping1 , Thbd
acute myeloid leukemiaBdkrb1 , Bdkrb2 , F3
acute myocardial infarctionC3 , Serping1
acute pancreatitisF7
acute promyelocytic leukemiaF3 , Plat , Thbd
Acute Traumatic CoagulopathyPlat
adenocarcinomaPlau , Serpina1
adult respiratory distress syndromeC3 , C5 , F3 , Mbl2 , Plau , Pros1 , Serpinc1 , Serpine1 , Thbd
age related macular degenerationCd46
age related macular degeneration 1C2 , Cfb
age related macular degeneration 13Cfi
age related macular degeneration 14C2 , Cfb
age related macular degeneration 15C9
age related macular degeneration 4Cfh
age related macular degeneration 7C3 , Cfb
age related macular degeneration 9C3
Airway ObstructionPlat , Tfpi
AlbuminuriaF7 , Serpine1
Alcoholic Fatty LiverSerpine1
alcoholic liver cirrhosisPlau
Alcoholic Liver DiseasesC6 , Cd59 , Plaur
allergic bronchopulmonary aspergillosisMbl2
allergic contact dermatitisF13a1 , Plat
allergic hypersensitivity diseaseKng2
allergic rhinitisF2 , Serpine1
alpha 1-antitrypsin deficiencySerpina1
Alpha-2-Macroglobulin DeficiencyA2m
alpha-2-plasmin inhibitor deficiencySerpinf2
Alzheimer's diseaseA2m , C1qb , C2 , C3 , C5ar1 , F2 , Mbl2 , Plau , Thbd
amenorrheaCpb2
amphetamine abuseCd55 , Cfh , Plat , Serpina5
amyloidosisSerpine1
amyotrophic lateral sclerosisC3 , C5ar1
amyotrophic lateral sclerosis type 1Masp2
AnaphylaxisKng2
Anemia, Refractory, with Excess of BlastsC3 , Cfb
AneurysmMbl2
Angina PectorisCpb2 , Plau
Angina, StableF7
angioedemaF12 , Plat , Serping1
Animal Disease ModelsF7 , Serpine1
ankylosing spondylitisThbd
anterior ischemic optic neuropathyF5
anterior uveitisC2 , C3 , Cd59 , Cfb , Cfh
anterolateral myocardial infarctionSerpine1
anti-basement membrane glomerulonephritisCfb
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisF3
antiphospholipid syndromeApoh , Plat , Proc
antithrombin III deficiencySerpinc1
anuriaPlau
anxiety disorderSerpina1
aortic aneurysmSerpine1
Aortic InjuriesVwf
Aortic RemodelingSerpine1
aortic valve insufficiencyMbl2
aphasiaPlat
appendicitisF2 , Plau
Arterial Occlusive DiseasesPlat , Plau
Arterial ThrombosisF7 , Mbl2 , Plat , Serpine1
arteriolosclerosisC3
arteriosclerosisApoh , F13a1 , F7 , Serpina1
ArteritisProc
arthus reactionCfd
asbestosisCfd , Serpina1
aspergillosisMbl1 , Mbl2
AsthenozoospermiaPlau
asthmaBdkrb2 , C3 , C3ar1 , C5 , C5ar1 , F2 , F7 , Fga , Mbl2 , Plau , Proc , Serpina1 , Serpine1 , Thbd
atherosclerosisF2 , Plat , Plau , Serpine1
atopic dermatitisC3 , F2 , Mbl2
atrial fibrillationTfpi , Vwf
atypical hemolytic-uremic syndromeC2 , C3 , C3ar1 , Cd46 , Cfb , Cfh , Cfi , Thbd
autism spectrum disorderKlkb1
autistic disorderC4b , Plaur , Serpine1
Autoimmune DiseasesC1s , C4b , F8
autoimmune hepatitisC1s , F2
autoimmune thrombocytopenic purpuraPlat
autoimmune thyroiditisMbl2
autosomal dominant polycystic kidney diseaseC9 , Cfb , Serping1
autosomal recessive nonsyndromic deafness 7F12
autosomal recessive polycystic kidney diseaseC3
Back PainPlat
background diabetic retinopathyA2m
BacteremiaCfh , Cpb2 , Mbl2 , Plat , Plaur , Serpinc1
bacterial infectious diseaseMbl2
bacterial meningitisCd46
bacterial pneumoniaC3 , C3ar1 , C5 , F2 , Mbl2 , Serpine1
bacterial vaginosisMbl2
basal laminar drusenCfh
Behcet's diseaseCfb , Cpb2 , F5 , Mbl2 , Proz , Serpine1 , Vwf
Bernard-Soulier syndromeVwf
beta thalassemiaCfb
bile duct diseaseF3
bilirubin metabolic disorderF12 , F7
bipolar disorderMbl2 , Serpina1 , Vwf
Birth WeightMbl2
blood coagulation diseaseF10 , F2 , F5 , Fga , Fgg , Plat , Proc , Pros1 , Proz , Serpinc1
Bone NeoplasmsPlau
boutonneuse feverC3 , Cfb
BradycardiaKng2
brain edemaC5 , F2 , F2r , Plat , Plau
brain infarctionCfh , Plat
Brain InjuriesC1qa , C3 , Cfb , F2 , Mbl2 , Serpinc1 , Thbd
brain ischemiaC3 , F2 , F2r , F5 , Fga , Plat , Plau , Proz , Serpine1
branched-chain keto acid dehydrogenase kinase deficiencyKng2
Breast NeoplasmsCd46 , Cd55 , Cd59 , Cfb , F10 , F3 , F5 , F7 , Plau , Serpine1
bronchiectasisMbl2 , Serpina1
bronchiolitis obliteransMbl2
bronchopneumoniaMbl2
Bronchopulmonary DysplasiaMbl2 , Serpine1
Budd-Chiari syndromeF5
bullous pemphigoidCfb , F2
BurnsA2m , Cpb2 , Fga , Plat , Serpina1 , Serping1 , Tfpi
C1q DeficiencyC1qa , C1qb , C1qc
C6 Deficiency, SubtotalC6
calcinosisC6
carcinomaPlaur
Carcinoma, Lewis LungC3
Cardiac Allograft VasculopathyF3
Cardiac ArrhythmiasKng2
Cardiac FibrosisF3 , Serpine1
cardiac tamponadePlat
Cardiogenic ShockPlat
CardiomegalyA2m , Plau
cardiomyopathyBdkrb2
cardiovascular system diseaseCfh , Fgb , Plaur , Vwf
carotid artery diseaseFgb , Plau , Vwf
Carotid Artery InjuriesPlat , Serpine1
carotid artery thrombosisF3 , Klkb1 , Serpind1 , Thbd
carotid stenosisF2
CD59 DeficiencyCd59
celiac diseaseF2
Central Nervous System Viral DiseasesPlat
central retinal vein occlusionProc
Central Serous ChorioretinopathySerpine1
Cerebral HemorrhageC3 , Cfh , F13a1 , F2 , F7 , Plat , Plau , Serpinc1
cerebral infarctionF2 , F5 , F7 , Plat , Plau , Plaur , Pros1 , Serpine1 , Serping1
Cerebral Small Vessel DiseasesFga , Fgg , Thbd
cerebrovascular diseaseF2 , F5 , Plau
cervix uteri carcinoma in situCd46
Chagas CardiomyopathyMbl2
Chagas diseaseF2
Chemical and Drug Induced Liver InjuryApoh , C3 , Cfh , Cpb2 , F13a1 , F3 , Fga , Kng2 , Plat , Plg , Serpina1 , Serping1 , Vwf
Chemotherapy-Induced Febrile NeutropeniaMbl2
cholestasisFga , Serpina1 , Serpina5 , Serpine1
cholesterol embolismPlat , Plau
chorioamnionitisMbl2
Choroidal NeovascularizationC5 , Cfb , Cfh , F7
Choroidal Neovascularization, ExperimentalSerpine1
Chronic Allograft DysfunctionC3 , F7
Chronic Allograft NephropathyPlau , Serpine1
chronic kidney diseaseCpb2
Chronic Lymphocytic Leukemia, B-CellThbd
chronic obstructive pulmonary diseaseBdkrb2 , C3 , C5 , C5ar1 , F2 , Mbl2 , Plau , Plaur , Serpina1 , Serpine1
Chronic Relapsing Experimental Autoimmune EncephalomyelitisSerpine1
Chronic RhinosinusitisMbl2
clear cell renal cell carcinomaF2
coccidioidomycosisMbl2
Colonic NeoplasmsA2m , Cd59 , F5 , Plau
Colorectal NeoplasmsF5 , F7
common variable immunodeficiencyCr2 , Mbl2
complement component 2 deficiencyC2 , Cfb
complement component 3 deficiencyC3
Complement Component 4, Partial Deficiency OfSerping1
complement component 4B deficiencyC4b
complement component 5 deficiencyC5
complement component 6 deficiencyC6
complement component 7 deficiencyC7
complement component 9 deficiencyC9
Complement Component C1r/C1s DeficiencyC1r
Complement Component C1s DeficiencyC1s
complement deficiencyC5 , C6
Complement Factor B DeficiencyC2 , Cfb
Complement Factor D DeficiencyCfd
Complement Factor H DeficiencyCfh
complement factor I deficiencyCfi
congenital afibrinogenemiaCfi , Fga , Fgb , Fgg
congenital hemolytic anemiaC3 , Cd46
Congenital Thrombotic Disease, due to Protein C DeficiencyProc
congestive heart failureCfd , Plat , Serpine1 , Vwf
conjunctivitisC3 , Cfb , Plg
contact dermatitisCd46
ContusionsF2
coronary artery diseaseF2 , F7 , Fgb , Serpina1 , Serpine1 , Serpinf2 , Thbd
Coronary DiseaseF12 , F13a1 , Plau , Serpinf2 , Thbd , Vwf
coronary restenosisF2r , Mbl2
coronary thrombosisPlat
Coronavirus InfectionsMbl2
CoughBdkrb2 , Kng2
Coumarin ResistanceF9
Coumarin SensitivityF9
Craniocerebral TraumaSerpinc1
Craniofacial AbnormalitiesMasp1
Crohn's diseaseF13a1 , F2 , Fga , Mbl2 , Plaur , Thbd
cryptococcal meningitisMbl2
cryptosporidiosisMbl2
Cutaneous Malignant Melanoma, Susceptibility To, 1Plg
cystic fibrosisC5 , Mbl2
Cytomegalovirus InfectionsMbl2
DeathF12
Dermal FibrosisSerpine1
dermatomyositisC2 , C9 , Mbl2 , Thbd
Diabetes ComplicationsBdkrb1 , Bdkrb2
diabetes mellitusApoh , Cpb2 , F3 , F7 , Serpine1 , Tfpi , Vwf
diabetic angiopathyBdkrb1 , F3 , Plat , Serpine1
Diabetic CardiomyopathiesA2m
Diabetic FootMbl2 , Plat
Diabetic NephropathiesApoh , Bdkrb2 , C3 , C5 , Cpb2 , F2 , F3 , Klkb1 , Kng2 , Plat , Plau , Pros1 , Serpine1
diabetic neuropathyBdkrb1 , F7 , Plat
diabetic retinopathyApoh , Bdkrb1 , Bdkrb2 , Cd59 , Cfb , Cfh , F13a1 , F7 , Serpine1 , Vwf
Diffuse PanbronchiolitisMbl2
disease by infectious agentMbl2 , Serpind1
disease of cellular proliferationPlaur , Tfpi
disseminated intravascular coagulationF13a1 , F2 , F3 , F7 , Fga , Plat , Proc , Serpinc1 , Serpine1 , Tfpi , Thbd
Drug EruptionsC4b , Kng2
Drug-Related Side Effects and Adverse ReactionsC3 , Fga , Plg , Serpina1 , Thbd
DysarthriaF5
Dysfibrinogenemia, CongenitalFga , Fgb , Fgg
DyspneaF5
DysprothrombinemiaF2
EczemaPlau
EdemaBdkrb1 , Kng2
EHLERS-DANLOS SYNDROME, PERIODONTAL TYPE, 2C1s
Ehlers-Danlos Syndrome, Type VIIIC1r , C1s
EmbolismPlat
Embolism and ThrombosisF3 , Plat , Tfpi
EmphysemaCd46 , Serpina1
end stage renal failureBdkrb1 , C6 , Cfb , F2 , F5 , Fgb , Mbl2 , Plau , Plaur , Serpine1 , Thbd , Vwf
Endometrial NeoplasmsCd46 , Cd55 , Cd59
endometriosisC1r , Cd55 , Cfd
EndotoxemiaC5ar1 , F12 , F2 , F3 , F5 , F7 , F8 , Fga , Plat , Proc , Serpinc1 , Serpine1 , Serping1 , Tfpi , Thbd , Vwf
Endotoxin-Induced UveitisThbd
EnterocolitisKlkb1
EosinophiliaBdkrb2 , Kng2
epilepsyBdkrb1 , Bdkrb2 , C1qa
ErythemaC9
erythema multiformeMasp2
Erythema NodosumC3 , Cfb
essential thrombocythemiaBdkrb1 , Bdkrb2 , Vwf
exanthemC1qa
Experimental ArthritisA2m , Bdkrb1 , C3 , C5 , Cd46 , Cd59 , Cfh , F2 , F2r , Klkb1 , Kng2 , Plau , Serpinc1 , Thbd
Experimental Autoimmune EncephalomyelitisA2m , C3 , C6 , Cpb2 , Serpine1
Experimental Autoimmune NeuritisCd59
Experimental Autoimmune OrchitisSerpina1
Experimental Autoimmune UveoretinitisC3 , Cfb
Experimental Diabetes MellitusBdkrb1 , Bdkrb2 , Cfd , F2 , F3 , F7 , Fga , Serpinc1 , Serpine1 , Vwf
Experimental Liver CirrhosisA2m , C1qa , C1qb , C1qc , C5ar1 , C7 , C8g , Cfd , F2r , F5 , Fgg , Kng2 , Plat , Plau , Plg , Pros1 , Serpinc1 , Thbd , Vwf
Experimental NeoplasmsF2r
Extrahepatic Portal Vein ObstructionF7
Extravasation of Diagnostic and Therapeutic MaterialsBdkrb2 , Kng2
eye diseaseF2
facial dermatosisC9
Facial Nerve InjuriesCd59
factor V deficiencyF5 , Tfpi
factor VII deficiencyF10 , F7
factor VIII deficiencyC3 , C5 , Cfb , F2 , F8 , F9 , Plat , Tfpi , Vwf
Factor VIII Deficiency, AcquiredF8
factor X deficiencyF10 , F7
factor XI deficiencyF11
factor XII deficiencyF12
factor XIII deficiencyF13a1 , F13b
Factor Xiii, A Subunit, Deficiency OfF13a1
Factor XIII, B Subunit, Deficiency OfF13b
familial adenomatous polyposisF5
Familial AmyloidosisFga
familial combined hyperlipidemiaSerpine1 , Thbd , Vwf
familial hypercholesterolemiaSerpine1
familial hyperlipidemiaF3 , F7 , Plau , Serpinc1 , Serpinf2 , Tfpi
familial Mediterranean feverSerpine1 , Thbd
familial visceral amyloidosisFga
fatty liver diseaseF2 , F2r , Plau , Serpine1
Female InfertilityProc
Femur Head NecrosisA2m , F2 , F5 , Plat , Tfpi
Fetal DeathF5 , Tfpi
Fetal Growth RetardationApoh , Serpine1
Fetal ResorptionApoh
FeverA2m , Serpine1
Fibromatosis, AggressiveSerpine1
fibrosarcomaSerpine1
FibrosisBdkrb1
Flaujeac Factor DeficiencyKng2
focal segmental glomerulosclerosisBdkrb1 , Cfb , Serpine1 , Vwf
fragile X syndromeSerpina1
frontotemporal dementiaMasp2
Fuchs' endothelial dystrophyC3
fungal infectious diseaseMbl2
Fungal Lung DiseasesC5
gastric ulcerF13a1
Gastrointestinal HemorrhageVwf
genetic diseaseF8 , F9 , Fgg , Pros1 , Serpina1 , Vwf
gestational diabetesMbl2 , Plat
Glandular and Epithelial NeoplasmsF7
glaucomaCfh , Serpine1
glioblastoma multiformeSerping1
gliosarcomaPlau
glomerulonephritisBdkrb1 , C1qa , C3 , C6 , Cd59 , Cfd , Cfh , Cpb2 , F2 , Klkb1 , Serpine1
Glomerulonephritis with Isolated C3 Deposits and Factor H DeficiencyCfh
glomerulosclerosisSerpine1
Graft Occlusion, VascularPlau
Graft vs Host DiseaseF3 , Serpine1 , Tfpi
Graves OphthalmopathySerpine1
Graves' diseaseC4b , Serpine1
Hashimoto DiseaseC1s , Mbl2
head and neck squamous cell carcinomaSerpine1
Hearing Loss, Noise-InducedCfi , Proc
Hearing Loss, SuddenSerpine1
heart diseaseA2m
Heart Rupture, Post-InfarctionPlau
heart valve diseaseC6
Heat StrokeProc , Serpinc1 , Thbd
Hematoma, Epidural, SpinalPlat
Hematoma, SubduralPlat
Hematoma, Subdural, AcuteF7
hematopoietic system diseaseSerpine1
HematuriaC3 , F7 , Plau
hemolytic anemiaA2m
hemolytic-uremic syndromeC3 , Cd46 , Cfb , Cfh , Cfi , Mbl2 , Plat , Thbd
hemophilia BF2 , F9
HemorrhageBdkrb2 , F10 , F13a1 , F2 , F3 , F7 , F8 , Plat , Plau , Serpina1 , Serpine1 , Serpinf2
hemorrhagic diseaseF7 , Vwf
Henoch-Schoenlein purpuraC3 , Kng2 , Plat , Plau
Heparin Cofactor II DeficiencySerpind1
HepatitisF2r
hepatitis BPlau , Plaur
Hepatitis C, ChronicPlau
Hepatitis, ChronicPlat
hepatocellular adenomaA2m
hepatocellular carcinomaA2m , C3 , C9 , F2 , Plau , Serpina1
hereditary angioedemaF12 , F2 , F7 , Kng2 , Serping1
Hereditary Angioedema Type IIIF12
Hereditary Angioedema Types I and IIC1s , Serping1
Hereditary ThrombophiliaF5
Hereditary Thrombophilia, due To Protein C Deficiency, Autosomal DominantProc
Hereditary Thrombophilia, due to Protein C Deficiency, Autosomal RecessiveProc
herpes simplexC3 , Mbl1 , Mbl2
Herpesviridae InfectionsC3 , Cd46
Hirschsprung Disease 1Plau
human immunodeficiency virus infectious diseaseC3 , Mbl2 , Plaur , Serpina1
Human InfluenzaC3 , Serping1
Huntington's diseaseF2
Hyaline Membrane DiseaseSerpine1
HyperalgesiaBdkrb1 , Bdkrb2 , C3 , F2 , F2r , Kng2 , Thbd
HypercholesterolemiaCpb2 , Serpinf2
HyperemiaBdkrb2 , Kng2
hypereosinophilic syndromeF5
HyperesthesiaKng2
hyperglycemiaF2 , F7
hyperhomocysteinemiaF10 , F12 , F2 , F8
HyperlipoproteinemiasApoh , Serpinf2
HyperoxiaPlau
hypersensitivity reaction type III diseaseC1qa , Masp2
hypertensionBdkrb1 , Bdkrb2 , C3 , F11 , F12 , F2r , F3 , F7 , Klkb1 , Kng2 , Plat , Plg , Proc , Serpina1 , Serpine1 , Serpinf2 , Thbd , Vwf
Hypertension, Pregnancy-InducedTfpi
hyperthyroidismSerpine1
HypertriglyceridemiaF7 , Serpinf2
HypertrophyF2
Hypertrophy, Left VentricularBdkrb1 , Bdkrb2 , Plau
Hypertrophy, Right VentricularPlat
HypoalbuminemiaA2m
Hypodysfibrinogenemia, CongenitalFga , Fgg
hypoglycemiaSerpina1
Hypophosphatemic Nephrolithiasis/OsteoporosisF12
Hypopituitarism and Septooptic 'Dysplasia'F9
HypotensionBdkrb2 , Kng2 , Plat , Plau
hypothyroidismF7 , Thbd
HypoxiaPlat , Tfpi
Hypoxia-Ischemia, BrainPlat , Plau , Serpine1
idiopathic pulmonary fibrosisF3 , Plau , Tfpi , Thbd
IgA glomerulonephritisC1qa , C1qb , C2 , C3 , Cfb , Plau
impotenceThbd
InflammationA2m , Bdkrb1 , Bdkrb2 , F2r , F3 , Fgg , Masp2 , Plau , Plaur , Serpinc1 , Serping1 , Thbd
inflammatory bowel diseaseKlkb1
inherited blood coagulation diseaseF7
Insulin ResistanceBdkrb1 , C1r , C3 , Cpb2 , F7 , Serpina1 , Serpine1 , Thbd , Vwf
intermediate coronary syndromeF7 , Plau , Serpinc1
interstitial lung diseaseSerpine1
Intestinal IschemiaCfh
Intestinal PolypsSerpine1
Intestinal Reperfusion InjuryF7 , Mbl2 , Proc , Serpinc1 , Serpine1 , Vwf
intracranial aneurysmPlau
Intracranial Embolism and ThrombosisPlat , Plau
Intracranial Hemorrhage, TraumaticF7
Intracranial HemorrhagesF7 , Plat , Plau , Serping1
intracranial sinus thrombosisF2
intracranial thrombosisPlat , Serpinc1 , Vwf
intracranial vasospasmPlat
invasive aspergillosisMbl2
Invasive Pulmonary AspergillosisMbl2
iron deficiency anemiaC1qa
irritant dermatitisC2
ischemiaPlau , Thbd
ischemic colitisSerpine1
Jaw CystsPlau
juvenile rheumatoid arthritisC8b , Mbl2 , Plaur , Pros1 , Tfpi , Thbd
Kartagener syndromeMbl2
Kawasaki diseaseMbl1 , Mbl2
KeloidFgg
keratoconusFga
Kidney CalculiF2
kidney diseaseCd46 , F7 , Fga
Kidney NeoplasmsPlau
Kidney Reperfusion InjuryBdkrb1 , C3 , Cfb , Cfh , F3 , Fga , Fgb , Fgg , Serpinc1 , Tfpi , Vwf
Kuhnt-Junius degenerationC3 , Cfi
lactic acidosisPlat
lattice corneal dystrophyF10 , F2
Legionnaires' diseaseMbl2
leishmaniasisC3
lepromatous leprosyC3 , Cfb , Mbl2
leptospirosisMbl2
leukemiaTfpi
LeukocytosisKng2
leukopeniaPlat
limited sclerodermaSerpine1
Lipoyltransferase 1 DeficiencyF9
liver cirrhosisA2m , C1qb , C5 , F2 , F2r , F3 , F5 , Klkb1 , Plau , Plaur , Serpina1 , Serping1 , Tfpi
liver diseaseMbl2 , Serpina1 , Thbd
Liver FailureF2
Liver InjuryFgg , Tfpi
liver neoplasmSerpine1
Liver Neoplasms, ExperimentalF12 , Serpina1
Liver Reperfusion InjuryC3 , Cfh , F3 , Fga , Proc , Serpinc1 , Serpine1 , Serping1 , Tfpi
Low Back PainPlat
lung diseaseA2m , Bdkrb2 , C3 , C3ar1 , C5 , C5ar1 , Serpina1 , Serpine1
Lung InjuryPlau , Plaur
Lung NeoplasmsA2m , Mbl2 , Plau , Serpina1 , Serping1
Lung Reperfusion InjuryProc , Serpine1
lupus nephritisC3 , Cfb , Cfh , Klkb1 , Mbl2 , Serping1
Lyme diseasePlaur
macular degenerationC2 , C3 , C9 , Cfb , Cfh , Cfi , Serpine1 , Serping1
macular retinal edemaApoh
malignant gliomaBdkrb2 , C3 , F2 , Plau , Serpine1
malignant mesotheliomaC9 , F9
Mammary Neoplasms, AnimalKng2
Mammary Neoplasms, ExperimentalPlau
Mannose-Binding Protein DeficiencyMbl2
MASP2 DeficiencyMasp2
mastitisC3
measlesCd46
melanomaC3 , Plg
melioidosisPlaur
membranoproliferative glomerulonephritisC1qa , Cfb , Cfh , Cfi , F5
membranous glomerulonephritisA2m , C3 , C7 , Cfb , Cfh , Plg
meningitisC8a , C8b , Plau , Plaur
Meningococcal InfectionsC3 , Cfb , Cfd , Cfh , Cpb2
meningococcal meningitisC9 , Cd46
meningoencephalitisPlat
mesangial proliferative glomerulonephritisVwf
Mesenteric IschemiaF2 , F5
mesenteric vascular occlusionSerpind1
Metabolic SyndromeC3 , F3 , Plat , Serpine1 , Thbd , Vwf
Microvascular AnginaBdkrb1 , Bdkrb2
middle cerebral artery infarctionC3 , F11 , F12 , Plat , Plau , Proc , Serpine1
mitral valve prolapsePlau
Mouth NeoplasmsFga , Plau
Multifocal ChoroiditisCfb , Cfh
multiple myelomaCd46 , Fgg
Multiple Organ FailureC5ar1 , Cpb2 , Plat , Serpinc1 , Serpine1 , Thbd
multiple sclerosisCd46 , Cfh
Multiple TraumaSerpine1
muscular atrophySerpine1
myasthenia gravisCfb
Myasthenia Gravis, Autoimmune, ExperimentalC3 , C6 , Cfb
myelofibrosisBdkrb1 , Bdkrb2
myeloid neoplasmF3
myocardial infarctionApoh , Bdkrb1 , Bdkrb2 , C3 , C7 , C8a , C8b , Cd59 , F10 , F12 , F13a1 , F2 , F3 , F5 , F7 , Fgb , Plat , Plau , Plaur , Proc , Serpine1 , Tfpi , Thbd , Vwf
Myocardial IschemiaC1qb , F3 , F5 , Serpina1
Myocardial Reperfusion InjuryC3 , C5 , Kng2 , Mbl1 , Mbl2 , Serpine1 , Serping1
Nasal PolypsMbl2 , Plaur
Neisseriaceae InfectionsC8a , C8b , Cfd
NeointimaF3 , Serpine1 , Tfpi
Neoplasm InvasivenessPlau , Plaur
Neoplasm MetastasisF2 , Plau , Plaur , Serpina1 , Serpinc1
Neoplasm Recurrence, LocalPlau
Neovascularization, PathologicSerpine1
nephritisBdkrb1 , Plau
Nephrolithiasis, Calcium OxalateF2
nephrosisCd59 , Cfh , F2
nephrotic syndromeA2m , Cpb2 , F3 , Serpinc1 , Serpine1 , Tfpi
Nerve DegenerationF2 , Plat
nervous system diseaseSerpine1
neurilemmomaSerpine1
neuroblastomaCd55
neurodegenerative diseaseSerpina1
neuronal ceroid lipofuscinosis 8F9
Neuropathy, PainfulThbd
neutropeniaC5 , C5ar1
newborn respiratory distress syndromeMbl2
nodular nonsuppurative panniculitisSerpina1
non-small cell lung carcinomaPlau , Thbd
nonalcoholic fatty liver diseaseF2 , Serpine1
Noonan syndromeF11 , Plat , Plg , Serpine1
obesityBdkrb1 , C3 , C5ar1 , Cfd , Cpb2 , F2 , F7 , Fgg , Mbl1 , Mbl2 , Plat , Plaur , Serpine1 , Thbd , Vwf
obstructive jaundiceCfh
obstructive lung diseaseA2m
obstructive sleep apneaSerpine1
ocular hypertensionC1qb , C3
opiate dependenceC9
Optic Nerve InjuriesC3 , Plau
oral squamous cell carcinomaPlau , Serpine1
osteoarthritisSerpina1
Osteoarthritis, KneeF2
osteoporosisFga , Fgb
otitis mediaC2 , C3 , Cfb , Mbl2
Otitis Media with EffusionC3
ovarian cystC1qb , Cfd
ovarian hyperstimulation syndromeF3 , Tfpi
Ovarian NeoplasmsCd46 , Cd59 , F2 , F7 , Mbl2 , Serpinc1
Ovary Reperfusion InjuryF3
Overactive Urinary BladderBdkrb1
Oxygen-Induced RetinopathySerpine1
PainBdkrb1 , Bdkrb2 , Kng2
pancreatic adenocarcinomaPlat
pancreatic cancerPlau , Serpina1
pancreatic ductal carcinomaSerpina1
pancreatitisBdkrb2 , Fga , Fgb , Fgg , Serpina1 , Serping1
Pancreatitis, Acute NecrotizingC5 , C5ar1 , Cd46 , Cd59 , Serpine1 , Serpinf2 , Serping1
Pancreatitis, Experimental, Acute Proc , Serpinc1 , Vwf
panic disorderMbl2
panuveitisCfh
Papillary Thyroid CancerPlau
paracoccidioidomycosisCfb
ParatuberculosisC1r , C3 , F2
ParesisPlat
Parkinson's diseaseA2m , Fgb
paroxysmal nocturnal hemoglobinuriaC3 , C5
Pediatric Crohn's DiseaseF2
pemphigusC3 , Mbl2
pericardial effusionPlat
perinatal necrotizing enterocolitisPlaur
peripheral artery diseaseSerpine1
Peripheral Nerve InjuriesPlau
peripheral nervous system diseaseMbl2
peripheral vascular diseaseApoh , Mbl2
Peritoneal AdhesionsSerpine1
Peritoneal FibrosisF10 , F3 , F5 , Serpinc1 , Serpine1
peritonitisA2m , C5 , Plat , Plau , Plaur
Peutz-Jeghers syndromeCfd
pigmentation diseaseMasp1
placental abruptionProc
placental insufficiencySerpine1
Plasminogen Activator Inhibitor-1 DeficiencySerpine1
Plasminogen Deficiency, Type IPlg
Plasmodium falciparum malariaMbl2
platelet-type bleeding disorder 10Serpine1
pleomorphic xanthoastrocytomaSerpine1
pleural empyemaPlau
pleurisyBdkrb1 , Bdkrb2 , C3 , Serpine1
Pneumococcal MeningitisSerping1
Pneumococcal PneumoniaC3 , C5 , Masp2 , Mbl2
pneumocystosisC3
pneumoniaBdkrb2 , C3 , C3ar1 , C5 , Mbl2 , Serpine1
Polycystic Kidney DiseasesC9 , Cfb
polycystic ovary syndromeSerpine1
polycythemiaSerpine1
polymyalgia rheumaticaMbl2
polyneuropathySerpine1
Polypoidal Choroidal VasculopathyC2 , Cfb , Cfh
portal hypertensionBdkrb2
posterior uveitisCfh
Postoperative ComplicationsF7
pre-eclampsiaC3 , Cd46 , F2 , F2r , F3 , F5 , Plaur , Proc , Serpina1 , Serpine1 , Serpinf2 , Tfpi
precursor B lymphoblastic lymphoma/leukemiaF13a1 , F3 , Tfpi
precursor lymphoblastic lymphoma/leukemiaCd46 , Cfb , F3 , Fga
Pregnancy ComplicationsSerpine1
Pregnancy in DiabeticsApoh
PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITY TO, 1F5
PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITY TO, 2F2
Prekallikrein DeficiencyKlkb1
Premature BirthMbl2
preterm premature rupture of the membranesF3 , Tfpi
primary hyperaldosteronismSerpina1
primary immunodeficiency diseaseC1qb , C3 , C5 , C8a , C8b , C9 , Cfd , Cfh
primary open angle glaucomaMbl2
prion diseasePlau , Plaur
proliferative diabetic retinopathySerpine1
proliferative vitreoretinopathyKng2
prostate cancerC3ar1 , C5 , F2 , F5
Prostatic NeoplasmsCd55 , Plau , Plaur , Serpine1
protein C deficiencyProc
protein S deficiencyPros1 , Tfpi
protein-losing enteropathyCd55
proteinuriaC6 , Cd55 , Cfh , F7 , Serpina1
prothrombin deficiencyF2 , F7
Prothrombin Deficiency, CongenitalF2
Pseudomonas InfectionsMbl2
psoriasisC2 , Cfb , Cfh , Cfi , Mbl2
pulmonary embolismF13a1 , F2 , F5 , Fga , Fgb , Fgg , Klkb1 , Plat , Plau , Proc , Pros1 , Serpinf2 , Thbd
pulmonary emphysemaFga , Serpina1
pulmonary eosinophiliaC3
pulmonary fibrosisBdkrb1 , Cfd , F2 , F5 , Mbl2 , Plau , Serpina1 , Serpine1 , Tfpi , Vwf
pulmonary hypertensionBdkrb2 , F5 , Serpina1 , Serpine1 , Thbd , Vwf
pulmonary sarcoidosisC3
pulmonary tuberculosisC3 , Mbl2 , Plaur
purpura fulminansProc
Purpura, ThrombocytopenicVwf
pyelonephritisCfb
Quebec platelet disorderPlau
Radiation NephropathySerpine1
Radiation PneumonitisC3 , C4bpa
relapsing-remitting multiple sclerosisSerpine1
renal cell carcinomaC4b , Cd46 , Plau , Vwf
renal fibrosisBdkrb1 , Cpb2 , Plau , Serpine1
Reperfusion InjuryC3 , C3ar1 , C5 , C5ar1 , Cd55 , Cd59 , Cfh , F2 , Mbl1 , Mbl2 , Plat , Plau , Plaur , Serping1 , Thbd
respiratory allergyMbl2 , Serpine1
respiratory failureMbl2 , Plat
Respiratory Tract InfectionsMbl2
retinal artery occlusionF5
retinal degenerationC3 , Cfb , Cfh
retinal drusenCfh
retinal vein occlusionF2 , F5 , Serpine1
retinopathy of prematuritySerpine1
Retrograde DegenerationC1qb
rheumatoid arthritisA2m , Bdkrb2 , C3 , C4b , F2 , Plaur , Thbd
rhinitisBdkrb1 , Bdkrb2 , C3 , C3ar1 , C5ar1 , Mbl2 , Plau , Serpine1
RhinosinusitisC3 , Serpine1
sagittal sinus thrombosisF5 , Plau , Pros1
sarcoidosisCfh
schizophreniaF2 , Serpind1 , Vwf
sciatic neuropathyBdkrb1 , Bdkrb2 , C3 , Plat , Plau , Serpine1
Seasonal Allergic RhinitisFga
sensorineural hearing lossF2 , F5 , Mbl2
SepsisA2m , C3 , C5 , C5ar1 , C6 , Cfb , Cfh , Cpb2 , F11 , F2 , F3 , F5 , F7 , F9 , Fga , Klkb1 , Mbl2 , Plat , Plau , Plaur , Proc , Serpine1 , Tfpi , Thbd
Septic PeritonitisF5
Shock, HemorrhagicCfh , F2 , F8 , Vwf
Shock, TraumaticSerping1
sickle cell anemiaC3 , Cfb , F13a1 , F2 , F3
silicosisC3
sinusitisCfb , Plau , Plaur
Sjogren's syndromeC3
Skeletal Muscle Reperfusion InjurySerping1
sleep apneaSerpine1
Smith-Magenis syndromeApoh
Smoke Inhalation InjuryF7 , Mbl2
Snake BitesF3
Spinal Cord CompressionPlat
Spinal Cord InjuriesC1qb , F2 , Plau , Plaur , Serpinc1 , Thbd , Vwf
Spinal Cord Reperfusion InjuryProc
SplenomegalyBdkrb1
squamous cell carcinomaCfh , Plau
status epilepticusPlat , Plau , Plaur
Stomach NeoplasmsF2r , Fgg , Plau , Serpina1 , Serpine1 , Thbd
StrokeApoh , Cfh , F12 , F13a1 , F2 , F5 , F8 , Fga , Fgb , Fgg , Kng2 , Plat , Plau , Proz , Serpine1 , Thbd , Vwf
Strongylida InfectionsPlau
Subarachnoid HemorrhageC3
Sudden Death, CardiacKng2
Systemic Inflammatory Response SyndromeCfh , F3 , Plaur , Thbd
systemic lupus erythematosusC1qa , C2 , C3 , C3ar1 , C4b , C5ar1 , Cd46 , Cfb , Cfh , Cr2 , F2 , Klkb1 , Mbl2 , Tfpi , Thbd
systemic sclerodermaC3 , Cfb , F2 , Serpine1 , Serpinf2 , Vwf
TachycardiaKng2
temporal arteritisMbl2
temporal lobe epilepsyBdkrb1 , Bdkrb2
Thiamine DeficiencySerpina1
thoracic aortic aneurysmSerpine1
thrombocytopeniaF7 , Fga , Mbl2
thrombocytosisCpb2
ThromboembolismCpb2 , F12 , F2 , F3 , F5 , F7 , F8 , Plat , Plau , Proc , Pros1 , Proz , Thbd
thrombophiliaC3 , C5 , Cd46 , F13a1 , F2 , F3 , F5 , F8 , Fga , Plg , Proc , Serpina10 , Serpind1 , Thbd
Thrombophilia due to Thrombomodulin DefectThbd
Thrombophilia, Familial, due to Decreased Release of Tissue Plasminogen ActivatorPlat
Thrombophilia, Hereditary, Due To Protein S Deficiency, Autosomal DominantPros1
Thrombophilia, Hereditary, Due To Protein S Deficiency, Autosomal RecessivePros1
thrombophlebitisPros1
thrombosisApoh , Bdkrb2 , C5ar1 , F10 , F11 , F2 , F2r , F3 , F5 , F9 , Fga , Fgb , Klkb1 , Plat , Plau , Proc , Pros1 , Serpinc1 , Serpine1 , Thbd , Vwf
Thrombotic MicroangiopathiesC3 , Cfh , Cfi , Cpb2 , F3 , Fgg , Vwf
thrombotic thrombocytopenic purpuraF3 , Proc , Tfpi , Thbd
Thrombotic Thrombocytopenic Purpura, AcquiredVwf
toxic encephalopathyPlat
toxic shock syndromeA2m , C5ar1 , Mbl2 , Plaur , Proc , Serpinc1 , Serpine1 , Serping1 , Tfpi
transient cerebral ischemiaC3 , F12 , Plat , Plau , Serpine1 , Tfpi , Vwf
transitional cell carcinomaPlau
Transplant RejectionPlat , Plau
tropical spastic paraparesisC3
trypanosomiasisA2m
type 1 diabetes mellitusApoh , C3 , Cfb , F7 , Mbl2 , Plat , Thbd , Vwf
type 2 diabetes mellitusApoh , C3 , Cpb2 , F12 , F2 , F3 , F7 , F8 , F9 , Fga , Fgb , Fgg , Plat , Plaur , Serpinc1 , Serpine1 , Thbd
type I complement component 8 deficiencyC8a
type II complement component 8 deficiencyC8b
ulcerative colitisF2 , Masp2 , Thbd
ureteral obstructionSerpine1
urinary bladder cancerF2 , Plau , Serpine1
Urinary CalculiF2
UrolithiasisPlau
urticariaF12 , F2
Uterine Cervical NeoplasmsCd46 , Cd55
Uterine HemorrhageF13a1
uveal melanomaSerpine1
Varicose UlcerMbl2
Vascular DepressionSerpine1
vascular diseasePros1
Vascular RemodelingSerpine1
vascular skin diseaseF2
Vascular System InjuriesBdkrb1 , Bdkrb2
vasculitisSerpina1
Vaso-occlusive CrisisMbl2
Venous ThromboembolismCd46 , F2 , F5 , Fga , Kng2 , Plat , Proc , Pros1 , Serpinc1 , Serpind1 , Serpine1 , Tfpi , Vwf
Venous ThrombosisF11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , Fga , Plat , Plau , Plg , Proc , Pros1 , Serpina10 , Serpina5 , Serpinc1 , Serpine1 , Tfpi
Ventilator-Induced Lung InjurySerpine1
Ventricular Dysfunction, LeftF2 , Plat
Ventricular FibrillationF2 , Plau
Viral BronchiolitisC3
Viral Hepatitis, HumanF2
viral infectious diseaseCd46
Viral MyocarditisF3 , Plau
visceral leishmaniasisMbl2
visual epilepsyC7 , Plau
vitiligoC3 , Mbl2
von Willebrand's diseaseF3 , Vwf
von Willebrand's disease 1Plat , Vwf
von Willebrand's disease 2F8 , Vwf
von Willebrand's disease 3Vwf
vulvovaginal candidiasisMbl2
Warfarin SensitivityF9
Wegener's granulomatosisThbd
Wilson diseaseA2m
Wounds and InjuriesPlat
Wounds, PenetratingC3 , Serpine1
X-Linked Thrombophilia, due to Factor IX DefectF9
Pathway Annotations Associated with Genes in the coagulation cascade pathway
Pathway TermsGene Symbols
acenocoumarol pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
alteplase pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
Alzheimer's disease pathwayA2m
aminocaproic acid pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
anistreplase pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
aprotinin pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
argatroban pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
B cell receptor signaling pathwayCr2
bivalirudin pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
calcium/calcium-mediated signaling pathwayBdkrb1 , Bdkrb2 , F2r
cell-extracellular matrix signaling pathwayVwf
Chagas disease pathwayBdkrb2 , C1qa , C1qb , C1qc , C3 , Serpine1
classical complement pathwayC3
coagulation cascade pathwayA2m , Apoh , Bdkrb1 , Bdkrb2 , C1qa , C1qb , C1qc , C1r , C1s , C2 , C3 , C3ar1 , C4b , C4bpa , C4bpb , C5 , C5ar1 , C6 , C7 , C8a , C8b , C8g , C9 , Cd46 , Cd55 , Cd59 , Cfb , Cfd , Cfh , Cfi , Cpb2 , Cr1l , Cr2 , F10 , F11 , F12 , F13a1 , F13b , F2 , F2r , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Kng2 , Kng2l1 , Masp1 , Masp2 , Mbl1 , Mbl2 , Plat , Plau , Plaur , Plg , Proc , Pros1 , Proz , Serpina1 , Serpina10 , Serpina5 , Serpinc1 , Serpind1 , Serpine1 , Serpinf2 , Serping1 , Tfpi , Thbd , Vwf
complement system pathwayA2m , Bdkrb1 , Bdkrb2 , C1qa , C1qb , C1qc , C1r , C1s , C2 , C3 , C3ar1 , C4b , C4bpa , C4bpb , C5 , C5ar1 , C6 , C7 , C8a , C8b , C8g , C9 , Cd46 , Cd55 , Cd59 , Cfb , Cfd , Cfh , Cfi , Cpb2 , Cr1l , Cr2 , F10 , F12 , F13a1 , F13b , F2 , F2r , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Kng2 , Kng2l1 , Masp1 , Masp2 , Mbl1 , Mbl2 , Plat , Plau , Plaur , Plg , Proc , Pros1 , Serpina1 , Serpina5 , Serpinc1 , Serpind1 , Serpine1 , Serpinf2 , Serping1 , Tfpi , Thbd , Vwf
dicoumarol pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
endocytosis pathwayF2r
enoxaparin pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg , Serpinc1
Entamoebiasis pathwayC8a , C8b , C8g , C9
ephrin - ephrin receptor bidirectional signaling axisFga , Fgb , Fgg
fibrinolysis pathwayCpb2 , Fga , Fgb , Fgg , Plat , Plau , Plg , Serpina5 , Serpine1 , Serpinf2
fibroblast growth factor signaling pathwayPlau , Plaur
fondaparinux pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg , Serpinc1
forkhead class A signaling pathwayC4bpb , F2 , Serpina1
G protein mediated signaling pathwayF2r
G protein mediated signaling pathway via Galphai familyBdkrb1 , Bdkrb2
G protein mediated signaling pathway via Galphaq familyBdkrb1 , Bdkrb2
glypican signaling pathwaySerpinc1
heparin pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg , Serpinc1
hypoxia inducible factor pathwaySerpine1
immune response pathwayA2m
inflammatory response pathwayA2m
influenza A pathwayPlg
interleukin-6 signaling pathwayA2m , Fgg
kallikrein-kinin cascade pathwayA2m , Bdkrb1 , Bdkrb2 , F12 , Klkb1 , Kng2 , Serping1
kinin signaling pathwayBdkrb1 , Bdkrb2 , Kng2
lectin complement pathwayMbl2
Leishmaniasis pathwayC3
measles pathwayCd46
myocarditis pathwayCd55
oxygen homeostasis pathwaySerpine1
p53 signaling pathwaySerpine1
phagocytosis pathwayC1r , C3 , Mbl1 , Mbl2
phenindione pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
platelet aggregation pathwayVwf
prion disease pathwayC1qa , C1qb , C1qc , C5 , C6 , C7 , C8a , C8b , C8g , C9
protease mediated signaling via protease-activated receptor 1F2 , F2r , Proc
protease mediated signaling via protease-activated receptor 2F10
protease mediated signaling via protease-activated receptor 3F2
protease mediated signaling via protease-activated receptor 4F2
protein C anticoagulant pathwayF2 , F5 , Proc , Pros1 , Thbd
reteplase pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
Staphylococcus aureus infection pathwayC1qa , C1qb , C1qc , C1r , C1s , C2 , C3 , C3ar1 , C4b , C5 , C5ar1 , Cfb , Cfd , Cfh , Cfi , Fgg , Masp1 , Masp2 , Mbl1 , Mbl2 , Plg
syndecan signaling pathwayF2 , Kng2 , Plg , Tfpi
systemic lupus erythematosus pathwayC1qa , C1qb , C1qc , C1r , C1s , C2 , C3 , C4b , C5 , C6 , C7 , C8a , C8b , C8g , C9
tranexamic acid pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
transforming growth factor-beta Smad dependent signaling pathwayA2m
tuberculosis pathwayC3
vitamin K metabolic pathwayF2
warfarin pharmacodynamics pathwayF10 , F11 , F12 , F13a1 , F13b , F2 , F3 , F5 , F7 , F8 , F9 , Fga , Fgb , Fgg , Klkb1 , Plat , Plg
Phenotype Annotations Associated with Genes in the coagulation cascade pathway

References Associated with the coagulation cascade pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: