RGD Reference Report - Molecular cloning of mRNA sequences transiently induced during rat liver regeneration. - Rat Genome Database

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Molecular cloning of mRNA sequences transiently induced during rat liver regeneration.

Authors: Sobczak, J  Lotti, AM  Taroux, P  Duguet, M 
Citation: Sobczak J, etal., Exp Cell Res 1987 Mar;169(1):47-56.
RGD ID: 728788
Pubmed: PMID:3817019   (View Abstract at PubMed)

In order to isolate genes which are induced during liver regeneration, we have constructed a cDNA library from 16-h-regenerating liver poly(A)+ RNA. By computer analysis of autoradiograms produced by differential plaque hybridization with cDNA from normal or 16-h-regenerating liver, we have isolated several recombinant clones representing sequences transiently increased during liver regeneration. Three of these were further characterized: the level of the corresponding mRNAs increase rapidly after partial hepatectomy, before the onset of DNA synthesis. Two clones were identified as fibrinogen clones. It is speculated that alpha-fibrinogen may be involved in the growth process, or in its regulation.



Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Fga  (fibrinogen alpha chain)

Objects referenced in this article
Gene Fgb fibrinogen beta chain Rattus norvegicus

Additional Information