Fgb (fibrinogen beta chain) - Rat Genome Database

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Gene: Fgb (fibrinogen beta chain) Mus musculus
Analyze
Symbol: Fgb
Name: fibrinogen beta chain
RGD ID: 734252
MGI Page MGI
Description: Predicted to enable chaperone binding activity; signaling receptor binding activity; and structural molecule activity. Predicted to contribute to cell adhesion molecule binding activity. Predicted to be involved in several processes, including blood coagulation; negative regulation of apoptotic process; and positive regulation of secretion by cell. Predicted to act upstream of or within adaptive immune response; hemostasis; and innate immune response. Located in cell cortex. Is active in synapse. Is expressed in several structures, including genitourinary system; gut; liver; lung; and telencephalon. Human ortholog(s) of this gene implicated in cardiovascular system disease (multiple); congenital afibrinogenemia; and end stage renal disease. Orthologous to human FGB (fibrinogen beta chain).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 2510049G14Rik; fibrinogen, B beta polypeptide
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,949,553 - 82,957,170 (-)NCBIGRCm39mm39
GRCm39 Ensembl382,947,448 - 82,957,170 (-)Ensembl
GRCm38383,042,246 - 83,049,863 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,040,141 - 83,049,863 (-)EnsemblGRCm38mm10GRCm38
MGSCv37382,846,225 - 82,853,712 (-)NCBIGRCm37mm9NCBIm37
MGSCv36383,128,230 - 83,135,717 (-)NCBImm8
Celera383,046,408 - 83,053,935 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
ADP  (ISO)
aluminium oxide  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
aniline  (ISO)
arotinoid acid  (ISO)
Azaspiracid  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
CHIR 99021  (ISO)
chromium trinitrate  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
dabigatran  (EXP)
dexamethasone  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dienogest  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
endosulfan  (ISO)
erythromycin estolate  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
furan  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
gestodene  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (EXP)
levonorgestrel  (ISO)
lithocholic acid  (ISO)
mercury dibromide  (ISO)
methidathion  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
N-nitrosomorpholine  (ISO)
nefazodone  (ISO)
nitrofen  (ISO)
norethisterone  (ISO)
norgestimate  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
potassium bromate  (ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
quinidine  (ISO)
Rebamipide  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
tacrolimus hydrate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
theophylline  (ISO)
titanium dioxide  (EXP)
tremolite asbestos  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP,ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Beta fibrinogen gene polymorphisms are associated with plasma fibrinogen and coronary artery disease in patients with myocardial infarction. The ECTIM Study. Etude Cas-Temoins sur l'Infarctus du Myocarde. Behague I, etal., Circulation. 1996 Feb 1;93(3):440-9.
3. Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study. Carty CL, etal., Thromb Haemost. 2008 Feb;99(2):388-95.
4. Quantitative organellar proteomics analysis of rough endoplasmic reticulum from normal and acute pancreatitis rat pancreas. Chen X, etal., J Proteome Res. 2010 Feb 5;9(2):885-96.
5. Epistatic effect of plasminogen activator inhibitor 1 and beta-fibrinogen genes on risk of glomerular microthrombosis in lupus nephritis: interaction with environmental/clinical factors. Gong R, etal., Arthritis Rheum. 2007 May;56(5):1608-17.
6. Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury. Gralinski LE, etal., mBio. 2013 Aug 6;4(4). pii: mBio.00271-13. doi: 10.1128/mBio.00271-13.
7. [Clinical and genetic analysis of 8 Chinese pedigrees with inherited dysfibrinogenemia]. Jiang M, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2014 Apr;31(2):134-9. doi: 10.3760/cma.j.issn.1003-9406.2014.02.002.
8. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
9. Haemostatic abnormalities persist despite glycaemic improvement by insulin therapy in lean type 2 diabetic patients. Knobl P, etal., Thromb Haemost. 1994 Jun;71(6):692-7.
10. Fibrinogen beta-derived Bbeta(15-42) peptide protects against kidney ischemia/reperfusion injury. Krishnamoorthy A, etal., Blood. 2011 Aug 18;118(7):1934-42. Epub 2011 Jun 17.
11. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
12. [The inherited procoagulant and prothrombotic condition as the main etiological factor for ischemic stroke in infants]. Lvova OA, etal., Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(9 Pt 2):13-20.
13. Antihypertensive pharmacogenetic effect of fibrinogen-beta variant -455G>A on cardiovascular disease, end-stage renal disease, and mortality: the GenHAT study. Lynch AI, etal., Pharmacogenet Genomics. 2009 Jun;19(6):415-21.
14. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. Fibrinogen and fibrin structure and functions. Mosesson MW J Thromb Haemost. 2005 Aug;3(8):1894-904.
17. Prenatal diagnosis for congenital afibrinogenemia caused by a novel nonsense mutation in the FGB gene in a Palestinian family. Neerman-Arbez M, etal., Blood. 2003 May 1;101(9):3492-4. Epub 2003 Jan 2.
18. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Mice lacking factor VII develop normally but suffer fatal perinatal bleeding. Rosen ED, etal., Nature 1997 Nov 20;390(6657):290-4.
26. Beta-fibrinogen gene polymorphism (C148-->T) is associated with carotid atherosclerosis: results of the Austrian Stroke Prevention Study. Schmidt H, etal., Arterioscler Thromb Vasc Biol. 1998 Mar;18(3):487-92.
27. Congenital afibrinogenemia: first identification of splicing mutations in the fibrinogen Bbeta-chain gene causing activation of cryptic splice sites. Spena S, etal., Blood 2002 Dec 15;100(13):4478-84. Epub 2002 Aug 1.
28. Proteomics of microparticles after experimental pulmonary embolism. Watts JA, etal., Thromb Res. 2011 Oct 17.
29. Bcl I polymorphism in the fibrinogen beta-chain gene is associated with the risk of familial myocardial infarction by increasing plasma fibrinogen levels. A case-control study in a sample of GISSI-2 patients. Zito F, etal., Arterioscler Thromb Vasc Biol. 1997 Dec;17(12):3489-94.
Additional References at PubMed
PMID:7613034   PMID:9788960   PMID:9819035   PMID:10349636   PMID:10749569   PMID:10829076   PMID:11018075   PMID:11042159   PMID:11076861   PMID:11159184   PMID:11434679   PMID:11891199  
PMID:12218060   PMID:12477932   PMID:12750384   PMID:15489334   PMID:15837518   PMID:15914557   PMID:15941850   PMID:16141072   PMID:16141073   PMID:16452087   PMID:16707424   PMID:16824188  
PMID:17505302   PMID:18554416   PMID:19423573   PMID:20152176   PMID:21098282   PMID:21267068   PMID:21305474   PMID:21873635   PMID:22159717   PMID:24194600   PMID:27140400   PMID:28071719  
PMID:28378742   PMID:30571485   PMID:32325033  


Genomics

Comparative Map Data
Fgb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,949,553 - 82,957,170 (-)NCBIGRCm39mm39
GRCm39 Ensembl382,947,448 - 82,957,170 (-)Ensembl
GRCm38383,042,246 - 83,049,863 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,040,141 - 83,049,863 (-)EnsemblGRCm38mm10GRCm38
MGSCv37382,846,225 - 82,853,712 (-)NCBIGRCm37mm9NCBIm37
MGSCv36383,128,230 - 83,135,717 (-)NCBImm8
Celera383,046,408 - 83,053,935 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.98NCBI
FGB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384154,562,980 - 154,572,807 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4154,563,011 - 154,572,807 (+)EnsemblGRCh38hg38GRCh38
GRCh374155,484,132 - 155,493,959 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364155,703,596 - 155,711,688 (+)NCBINCBI36hg18NCBI36
Build 344155,841,767 - 155,849,841NCBI
Celera4152,815,112 - 152,824,894 (+)NCBI
Cytogenetic Map4q31.3NCBI
HuRef4151,224,828 - 151,234,610 (+)NCBIHuRef
CHM1_14155,462,053 - 155,471,836 (+)NCBICHM1_1
T2T-CHM13v2.04157,894,764 - 157,904,590 (+)NCBI
Fgb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22168,394,901 - 168,402,863 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2168,394,916 - 168,405,979 (-)Ensembl
Rnor_6.02182,028,044 - 182,035,026 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,027,115 - 182,038,178 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02201,442,664 - 201,449,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42174,768,193 - 174,775,102 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12174,718,265 - 174,725,209 (-)NCBI
Celera2162,422,542 - 162,429,467 (-)NCBICelera
Cytogenetic Map2q34NCBI
Fgb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554718,822,965 - 8,832,884 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,824,901 - 8,832,836 (-)NCBIChiLan1.0ChiLan1.0
FGB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14158,747,659 - 158,755,766 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4158,747,659 - 158,755,766 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04146,929,561 - 146,937,665 (+)NCBIMhudiblu_PPA_v0panPan3
FGB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11552,220,690 - 52,228,526 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1552,220,611 - 52,228,250 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1552,565,222 - 52,573,066 (+)NCBI
ROS_Cfam_1.01552,907,656 - 52,915,500 (+)NCBI
ROS_Cfam_1.0 Ensembl1552,907,681 - 52,915,468 (+)Ensembl
UMICH_Zoey_3.11552,162,583 - 52,170,431 (+)NCBI
UNSW_CanFamBas_1.01552,267,207 - 52,275,052 (+)NCBI
UU_Cfam_GSD_1.01552,581,569 - 52,589,416 (+)NCBI
Fgb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,233,115 - 38,240,864 (-)NCBI
SpeTri2.0NW_0049365761,306,076 - 1,313,485 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl874,594,255 - 74,607,360 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1874,598,170 - 74,607,409 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2878,952,697 - 78,961,938 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17101,106,468 - 101,114,566 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl7101,106,483 - 101,114,662 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603780,761,750 - 80,769,888 (+)NCBIVero_WHO_p1.0
Fgb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248585,864,784 - 5,874,869 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248585,866,104 - 5,874,173 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D18026  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38383,042,245 - 83,042,354UniSTSGRCm38
MGSCv37382,846,167 - 82,846,276UniSTSGRCm37
Celera383,046,350 - 83,046,459UniSTS
Cytogenetic Map3E3UniSTS
cM Map348.2UniSTS
Whitehead_YAC3 UniSTS
Fgb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38383,042,577 - 83,043,397UniSTSGRCm38
Celera383,046,682 - 83,047,502UniSTS
Cytogenetic Map3E3UniSTS
cM Map336.98UniSTS
RH143374  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38383,042,522 - 83,043,257UniSTSGRCm38
MGSCv37382,846,444 - 82,847,179UniSTSGRCm37
Celera383,046,627 - 83,047,362UniSTS
Cytogenetic Map3E3UniSTS
cM Map348.2UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4935758183357581Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34949500583495118Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34949500583495118Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35262550986625745Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35262550986625745Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35262550986625745Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35292318386923183Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:55
Interacting mature miRNAs:60
Transcripts:ENSMUST00000048246
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_181849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC138394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF413205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW110458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY155342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF605471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000048246   ⟹   ENSMUSP00000039472
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl382,947,448 - 82,957,170 (-)Ensembl
GRCm38.p6 Ensembl383,040,141 - 83,049,863 (-)Ensembl
RefSeq Acc Id: NM_181849   ⟹   NP_862897
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39382,949,553 - 82,957,170 (-)NCBI
GRCm38383,042,246 - 83,049,863 (-)NCBI
MGSCv37382,846,225 - 82,853,712 (-)RGD
Celera383,046,408 - 83,053,935 (-)RGD
cM Map3 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_862897   ⟸   NM_181849
- Peptide Label: preproprotein
- UniProtKB: Q8K0E8 (UniProtKB/Swiss-Prot),   Q3TGR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000039472   ⟸   ENSMUST00000048246
Protein Domains
Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K0E8-F1-model_v2 AlphaFold Q8K0E8 1-481 view protein structure

Promoters
RGD ID:6848767
Promoter ID:MM_TRO:6258
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   Lung,   Spleen
Transcripts:MTR012771.3.1033.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36382,847,009 - 82,847,509 (-)MPROMDB
RGD ID:6847744
Promoter ID:MM_ACW:32098
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:FGB.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36382,850,521 - 82,851,021 (-)MPROMDB
RGD ID:6833778
Promoter ID:MM_KWN:34686
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000048246
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36382,853,521 - 82,854,021 (-)MPROMDB
RGD ID:6880972
Promoter ID:EPDNEW_M3937
Type:multiple initiation site
Name:Fgb_1
Description:Mus musculus fibrinogen beta chain , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38383,049,809 - 83,049,869EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99501 AgrOrtholog
Ensembl Genes ENSMUSG00000033831 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000039472 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000048246 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.215.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fibrinogen-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_coil_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:99501 ENTREZGENE
NCBI Gene 110135 ENTREZGENE
PANTHER PTHR19143:SF332 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Fib_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB FGB RGD
PhenoGen Fgb PhenoGen
PROSITE FIBRINOGEN_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIBRINOGEN_C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FBG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fib_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56496 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt FIBB_MOUSE UniProtKB/Swiss-Prot
  Q3TGR2 ENTREZGENE, UniProtKB/TrEMBL
  Q8K0E8 ENTREZGENE
UniProt Secondary Q91ZP1 UniProtKB/Swiss-Prot