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The fibrinolytic pathway is activated by fibrin clots. Coagulation, anticoagulant systems and fibrinolysis pathways coordinate to maintain proper hemostasis. The coagulation cascade, tightly controlled by anticoagulation and intimately connected with the complement system of innate immunity, culminates in the activation of thrombin (F2) - the last protease of the cascade, and the subsequent formation of insoluble fibrin clots. Fibrin, in turn, is a substrate for the initiation of the fibrinolyti

Pathway Diagram:

Elsevier Inc. Serpine1 other fibrinolysis serpin inhibitors fibrin coagulation cascade pathway Plaur Plg receptors other plasmin substrates Serpinf2 plasmin Plg Plat Plau Cpb2 Plg ---- Plg receptors Plau ---- Plaur Cpb2 ---> fibrin Cpb2 ---| fibrin plasmin ---> other plasmin substrates Plat ---> Plg Serpinf2 ---| plasmin plasmin ---- Serpinf2 Serpine1 ---| Plat Serpine1 ---| Plau fibrin ---- Plg Plau ---> Plg Plau --+> plasmin clot dissolution plasmin ---> fibrin fibrin ---- Plat Plat --+> plasmin Plau ---- Serpine1 Plat ---- Serpine1 coagulation cascade pathway --+> fibrin

Genes in Pathway:

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fibrinolysis pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cpb2 carboxypeptidase B2 JBrowse link 15 57,290,849 57,339,762 RGD:11352249
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:11352249
G Fgb fibrinogen beta chain JBrowse link 2 182,028,044 182,035,026 RGD:11352249
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:11352249
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:11352249
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:11352249
G Plg plasminogen JBrowse link 1 48,521,828 48,563,895 RGD:11352249
G Serpina5 serpin family A member 5 JBrowse link 6 127,753,152 127,772,403 RGD:11352249
G Serpinb2 serpin family B member 2 JBrowse link 13 27,449,907 27,463,015 RGD:11352249
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:11352249
G Serpine2 serpin family E member 2 JBrowse link 9 85,560,852 85,629,410 RGD:11352249
G Serpinf2 serpin family F member 2 JBrowse link 10 62,264,247 62,272,353 RGD:11352249

Pathway Gene Annotations

Disease Annotations Associated with Genes in the fibrinolysis pathway
Disease TermsGene Symbols
abdominal aortic aneurysmSerpine1
Acquired Protein C DeficiencySerpine1
acute kidney failureFga , Plat , Plg
Acute Liver FailureFga
Acute Lung InjuryFga , Plau , Serpine1
Acute Necrotizing PancreatitisSerpine1 , Serpinf2
acute promyelocytic leukemiaPlat
Acute Traumatic CoagulopathyPlat
adult respiratory distress syndromePlau , Serpine1
Aggressive FibromatosisSerpine1
Airway ObstructionPlat
Alcoholic Fatty LiverSerpine1
alcoholic liver cirrhosisPlau
allergic contact dermatitisPlat
allergic rhinitisSerpine1
alpha-2-plasmin inhibitor deficiencySerpinf2
Alzheimer's diseasePlau , Serpine2
Alzheimer's disease 1Plau
amphetamine abusePlat , Serpina5
Angina PectorisCpb2 , Plau
Animal Disease ModelsSerpine1
anterolateral myocardial infarctionSerpine1
antiphospholipid syndromePlat
aortic aneurysmSerpine1
Aortic RemodelingSerpine1
Arterial Occlusive DiseasesPlat , Plau
Arterial ThrombosisPlat , Serpine1
asthmaFga , Plau , Serpine1
atherosclerosisPlat , Plau , Serpine1
autistic disorderSerpine1
autoimmune thrombocytopenic purpuraPlat
Back PainPlat
BacteremiaCpb2 , Plat
bacterial pneumoniaSerpine1
Behcet's diseaseCpb2 , Serpine1
blood coagulation diseaseFga , Fgg , Plat
Bone NeoplasmsPlau
brain edemaPlat , Plau , Serpine2
brain infarctionPlat
brain ischemiaFga , Plat , Plau , Serpine1
breast cancerPlau , Serpine1
Breast NeoplasmsSerpinb2
Bronchopulmonary DysplasiaSerpine1
BurnsCpb2 , Fga , Plat
Cardiac FibrosisSerpine1
cardiac tamponadePlat
Cardiogenic ShockPlat
cardiovascular system diseaseFgb
carotid artery diseaseFgb , Plau
Carotid Artery InjuriesPlat , Serpine1
Central Nervous System Viral DiseasesPlat
Central Serous ChorioretinopathySerpine1
Cerebral HemorrhagePlat , Plau
cerebral infarctionPlat , Plau , Serpine1
Cerebral Small Vessel DiseasesFga , Fgg
cerebrovascular diseasePlau
Chemical and Drug Induced Liver InjuryCpb2 , Fga , Plat , Plg
cholestasisFga , Serpina5 , Serpine1
cholesterol embolismPlat , Plau
Choroidal Neovascularization, ExperimentalSerpine1
Chronic Allograft NephropathyPlau , Serpine1
Chronic HepatitisPlat
chronic kidney diseaseCpb2
chronic obstructive pulmonary diseasePlau , Serpine1
Chronic Relapsing Experimental Autoimmune EncephalomyelitisSerpine1
Colonic NeoplasmsPlau
congenital afibrinogenemiaFga , Fgb , Fgg
Congenital HypodysfibrinogenemiaFga , Fgb , Fgg
congenital myopathyFgg
congestive heart failurePlat , Serpine1
coronary artery diseaseFgb , Serpine1 , Serpinf2
Coronary DiseasePlau , Serpinf2
coronary thrombosisPlat
Crohn's diseaseFga
Dermal FibrosisSerpine1
diabetes mellitusCpb2 , Serpine1
Diabetes Mellitus, Experimental Fga , Serpine1
diabetic angiopathyPlat , Serpine1
Diabetic FootPlat
Diabetic NephropathiesCpb2 , Plat , Plau , Serpine1
diabetic neuropathyPlat
diabetic retinopathySerpine1
disseminated intravascular coagulationFga , Plat , Serpine1
Drug-Related Side Effects and Adverse ReactionsFga , Plg
Dysfibrinogenemia, CongenitalFga , Fgb , Fgg
Embolism and ThrombosisPlat
end stage renal failureFgb , Plau , Serpine1
EndotoxemiaFga , Plat , Serpine1
Experimental ArthritisPlau
Experimental Autoimmune EncephalomyelitisCpb2 , Serpine1
Experimental Liver CirrhosisFgg , Plat , Plau , Plg
factor VIII deficiencyPlat
Familial AmyloidosisFga
familial combined hyperlipidemiaSerpine1
familial hypercholesterolemiaSerpine1
familial hyperlipidemiaPlau , Serpinf2
familial Mediterranean feverSerpine1
familial visceral amyloidosisFga
fatty liver diseasePlau , Serpine1
Femur Head NecrosisPlat
Fetal Growth RetardationSerpine1
focal segmental glomerulosclerosisSerpine1
genetic diseaseFgg
gestational diabetesPlat
glomerulonephritisCpb2 , Serpine1
Graft Occlusion, VascularPlau
Graft vs Host DiseaseSerpine1
Graves OphthalmopathySerpine1
Graves' diseaseSerpine1
head and neck squamous cell carcinomaSerpine1
Hearing Loss, SuddenSerpine1
Heart Rupture, Post-InfarctionPlau
Hematoma, Epidural, SpinalPlat
Hematoma, SubduralPlat
hematopoietic system diseaseSerpine1
hemolytic-uremic syndromePlat
HemorrhagePlat , Plau , Serpine1 , Serpinf2
Henoch-Schoenlein purpuraPlat , Plau
hepatitis BPlau
Hepatitis C, ChronicPlau
hepatocellular carcinomaPlau
Hirschsprung Disease 1Plau
Hyaline Membrane DiseaseSerpine1
HypercholesterolemiaCpb2 , Serpinf2
hypertensionPlat , Plg , Serpine1 , Serpine2 , Serpinf2
HypotensionPlat , Plau
Hypoxia-Ischemia, BrainPlat , Plau , Serpine1
idiopathic pulmonary fibrosisPlau
IgA glomerulonephritisPlau
InflammationFgg , Plau
Insulin ResistanceCpb2 , Serpine1
intermediate coronary syndromePlau
interstitial lung diseaseSerpine1
Intestinal PolypsSerpine1
Intestinal Reperfusion InjurySerpine1
intracranial aneurysmPlau
Intracranial Embolism and ThrombosisPlat , Plau
Intracranial HemorrhagesPlat , Plau
intracranial thrombosisPlat
intracranial vasospasmPlat
ischemic colitisSerpine1
Jaw CystsPlau
kidney diseaseFga
Kidney NeoplasmsPlau
Kidney Reperfusion InjuryFga , Fgb , Fgg
lactic acidosisPlat
Left Ventricular HypertrophyPlau
limited sclerodermaSerpine1
liver benign neoplasmSerpine1
liver cirrhosisPlau
liver diseaseSerpine1
Liver InjuryFgg
Liver Reperfusion InjuryFga , Serpine1
Low Back PainPlat
lung diseaseSerpine1
Lung InjuryPlau
Lung NeoplasmsPlau
Lung Reperfusion InjurySerpine1
macular degenerationSerpine1
malignant gliomaPlau , Serpine1
Mammary Neoplasms, ExperimentalPlau
membranous glomerulonephritisPlg
Meningococcal InfectionsCpb2
Metabolic SyndromePlat , Serpine1
middle cerebral artery infarctionPlat , Plau , Serpine1
mitral valve prolapsePlau
Mouth NeoplasmsFga , Plau
multiple myelomaFgg
Multiple Organ FailureCpb2 , Plat , Serpine1
Multiple TraumaSerpine1
muscular atrophySerpine1
myocardial infarctionFgb , Plat , Plau , Serpine1
Myocardial Reperfusion InjurySerpine1
Neoplasm InvasivenessPlau
Neoplasm MetastasisPlau
Neoplasm Recurrence, LocalPlau
Neovascularization, PathologicSerpine1
nephrotic syndromeCpb2 , Serpine1
Nerve DegenerationPlat
nervous system diseaseSerpine1
non-small cell lung carcinomaPlau
nonalcoholic fatty liver diseaseSerpinb2 , Serpine1
Noonan syndromePlat , Plg , Serpine1
obesityCpb2 , Fgg , Plat , Serpine1
obstructive sleep apneaSerpine1
Optic Nerve InjuriesPlau
oral squamous cell carcinomaPlau , Serpine1
osteoporosisFga , Fgb
Oxygen-Induced RetinopathySerpine1
pancreatic adenocarcinomaPlat
pancreatic cancerPlau
pancreatitisFga , Fgb , Fgg
papillary thyroid carcinomaPlau
Parkinson's diseaseFgb
pericardial effusionPlat
peripheral artery diseaseSerpine1
Peripheral Nerve InjuriesPlau
peripheral nervous system diseaseSerpinb2
Peritoneal AdhesionsSerpine1
Peritoneal FibrosisSerpine1
peritonitisPlat , Plau
placental insufficiencySerpine1
Plasminogen Activator Inhibitor-1 DeficiencySerpine1
Plasminogen Deficiency, Type IPlg
platelet-type bleeding disorder 10Serpine1
pleomorphic xanthoastrocytomaSerpine1
pleural empyemaPlau
polycystic ovary syndromeSerpine1
pre-eclampsiaSerpine1 , Serpinf2
precursor lymphoblastic lymphoma/leukemiaFga
Pregnancy ComplicationsSerpine1
prion diseasePlau
proliferative diabetic retinopathySerpine1
prostate cancerPlau
Prostatic NeoplasmsPlau , Serpine1
pulmonary embolismFga , Fgb , Fgg , Plat , Plau , Serpinf2
pulmonary emphysemaFga
pulmonary fibrosisPlau , Serpine1
pulmonary hypertensionSerpine1
Quebec platelet disorderPlau
Radiation NephropathySerpine1
relapsing-remitting multiple sclerosisSerpine1
renal cell carcinomaPlau
renal fibrosisCpb2 , Plau , Serpine1
Reperfusion InjuryPlat , Plau , Serpine2
respiratory allergySerpine1
respiratory failurePlat
retinal vein occlusionSerpine1
retinopathy of prematuritySerpine1
rhinitisPlau , Serpine1
Right Ventricular HypertrophyPlat
sagittal sinus thrombosisPlau
sciatic neuropathyPlat , Plau , Serpine1
Seasonal Allergic RhinitisFga
SepsisCpb2 , Fga , Plat , Plau , Serpine1
sleep apneaSerpine1
Spinal Cord CompressionPlat
Spinal Cord InjuriesPlau
squamous cell carcinomaPlau
status epilepticusPlat , Plau
Stomach NeoplasmsFgg , Plau , Serpinb2 , Serpine1
StrokeFga , Fgb , Fgg , Plat , Plau , Serpine1
Strongylida InfectionsPlau
systemic sclerodermaSerpine1 , Serpinf2
thoracic aortic aneurysmSerpine1
ThromboembolismCpb2 , Plat , Plau
thrombophiliaFga , Plg
Thrombophilia, Familial, due to Decreased Release of Tissue Plasminogen ActivatorPlat
thrombosisFga , Fgb , Plat , Plau , Serpine1
Thrombotic MicroangiopathiesCpb2 , Fgg
toxic encephalopathyPlat
toxic shock syndromeSerpine1
transient cerebral ischemiaPlat , Plau , Serpine1
transitional cell carcinomaPlau
Transplant RejectionPlat , Plau
type 1 diabetes mellitusPlat
type 2 diabetes mellitusCpb2 , Fga , Fgb , Fgg , Plat , Serpine1
ureteral obstructionSerpine1
urinary bladder cancerPlau , Serpine1
uveal melanomaSerpine1
Vascular DepressionSerpine1
Vascular RemodelingSerpine1
Venous ThromboembolismFga , Plat , Serpine1
Venous ThrombosisFga , Plat , Plau , Plg , Serpina5 , Serpine1
Ventilator-Induced Lung InjurySerpine1
Ventricular Dysfunction, LeftPlat
Ventricular FibrillationPlau
Viral MyocarditisPlau
visual epilepsyPlau
von Willebrand's disease 1Plat
Wounds and InjuriesPlat
Wounds, PenetratingSerpine1
Pathway Annotations Associated with Genes in the fibrinolysis pathway
Pathway TermsGene Symbols
acenocoumarol pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
alteplase pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
aminocaproic acid pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
anistreplase pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
aprotinin pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
argatroban pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
bivalirudin pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
Chagas disease pathwaySerpine1
coagulation cascade pathwayCpb2 , Fga , Fgb , Fgg , Plat , Plau , Plg , Serpina5 , Serpine1 , Serpinf2
complement system pathwayCpb2 , Fga , Fgb , Fgg , Plat , Plau , Plg , Serpina5 , Serpine1 , Serpinf2
dicoumarol pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
enoxaparin pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
Entamoebiasis pathwaySerpinb2
ephrin - ephrin receptor bidirectional signaling axisFga , Fgb , Fgg
fibrinolysis pathwayCpb2 , Fga , Fgb , Fgg , Plat , Plau , Plg , Serpina5 , Serpinb2 , Serpine1 , Serpine2 , Serpinf2
fibroblast growth factor signaling pathwayPlau
fondaparinux pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
heparin pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
hypoxia inducible factor pathwaySerpine1
influenza A pathwayPlg
interleukin-6 signaling pathwayFgg
oxygen homeostasis pathwaySerpine1
p53 signaling pathwaySerpine1
phenindione pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
reteplase pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
Staphylococcus aureus infection pathwayFgg , Plg
syndecan signaling pathwayPlg
tranexamic acid pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
warfarin pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
Phenotype Annotations Associated with Genes in the fibrinolysis pathway

References Associated with the fibrinolysis pathway:

Ontology Path Diagram:

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