FIBRINOLYSIS PATHWAY (PW:0000481)

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Description

The fibrinolytic pathway is activated by fibrin clots. Coagulation, anticoagulant systems and fibrinolysis pathways coordinate to maintain proper hemostasis. The coagulation cascade, tightly controlled by anticoagulation and intimately connected with the complement system of innate immunity, culminates in the activation of thrombin (F2) - the last protease of the cascade, and the subsequent formation of insoluble fibrin clots. Fibrin, in turn, is a substrate for the initiation of the fibrinolyti

Pathway Diagram:

Elsevier Inc. Serpine1 other fibrinolysis serpin inhibitors fibrin coagulation cascade pathway Plaur Plg receptors other plasmin substrates Serpinf2 plasmin Plg Plat Plau Cpb2 Plg ---- Plg receptors Plau ---- Plaur Cpb2 ---> fibrin Cpb2 ---| fibrin plasmin ---> other plasmin substrates Plat ---> Plg Serpinf2 ---| plasmin plasmin ---- Serpinf2 Serpine1 ---| Plat Serpine1 ---| Plau fibrin ---- Plg Plau ---> Plg Plau --+> plasmin clot dissolution plasmin ---> fibrin fibrin ---- Plat Plat --+> plasmin Plau ---- Serpine1 Plat ---- Serpine1 coagulation cascade pathway --+> fibrin
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Genes in Pathway:

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fibrinolysis pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cpb2 carboxypeptidase B2 JBrowse link 15 57,290,849 57,339,762 RGD:11352249
G Fga fibrinogen alpha chain JBrowse link 2 181,997,562 182,013,726 RGD:11352249
G Fgb fibrinogen beta chain JBrowse link 2 182,028,044 182,035,026 RGD:11352249
G Fgg fibrinogen gamma chain JBrowse link 2 181,987,080 181,994,523 RGD:11352249
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:11352249
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:11352249
G Plg plasminogen JBrowse link 1 48,521,828 48,563,895 RGD:11352249
G Serpina5 serpin family A member 5 JBrowse link 6 127,753,152 127,772,403 RGD:11352249
G Serpinb2 serpin family B member 2 JBrowse link 13 27,449,907 27,463,015 RGD:11352249
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:11352249
G Serpine2 serpin family E member 2 JBrowse link 9 85,560,852 85,629,410 RGD:11352249
G Serpinf2 serpin family F member 2 JBrowse link 10 62,264,247 62,272,353 RGD:11352249

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the fibrinolysis pathway
Pathway TermsGene Symbols
acenocoumarol pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
alteplase pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
aminocaproic acid pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
anistreplase pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
aprotinin pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
argatroban pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
bivalirudin pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
coagulation cascade pathwayCpb2 , Fga , Fgb , Fgg , Plat , Plau , Plg , Serpina5 , Serpine1 , Serpinf2
complement system pathwayCpb2 , Fga , Fgb , Fgg , Plat , Plau , Plg , Serpina5 , Serpine1 , Serpinf2
dicoumarol pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
enoxaparin pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
Entamoeba histolyca infection pathwaySerpinb2
ephrin - ephrin receptor bidirectional signaling axisFga , Fgb , Fgg
fibrinolysis pathwayCpb2 , Fga , Fgb , Fgg , Plat , Plau , Plg , Serpina5 , Serpinb2 , Serpine1 , Serpine2 , Serpinf2
fibroblast growth factor signaling pathwayPlau
fondaparinux pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
heparin pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
hypoxia inducible factor pathwaySerpine1
influenza A virus infection pathwayPlg
interleukin-6 signaling pathwayFgg
oxygen homeostasis pathwaySerpine1
p53 signaling pathwaySerpine1
phenindione pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
reteplase pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
Staphylococcus aureus infection pathwayFgg , Plg
syndecan signaling pathwayPlg
tranexamic acid pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
Trypanosoma cruzi infection pathwaySerpine1
warfarin pharmacodynamics pathwayFga , Fgb , Fgg , Plat , Plg
Phenotype Annotations Associated with Genes in the fibrinolysis pathway
Phenotype TermsGene Symbols
decreased metastatic potentialSerpine1

References Associated with the fibrinolysis pathway:

Ontology Path Diagram:

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