RGD Reference Report - Basic mechanisms and regulation of fibrinolysis. - Rat Genome Database

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Basic mechanisms and regulation of fibrinolysis.

Authors: Longstaff, C  Kolev, K 
Citation: Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
RGD ID: 11352249
Pubmed: PMID:26149056   (View Abstract at PubMed)
DOI: DOI:10.1111/jth.12935   (Journal Full-text)

Fibrinolysis appears in many diverse physiological situations, and the components of the system are well established, along with mechanistic details for the individual reactions and some high-resolution structures. Key questions in understanding the regulation of fibrinolysis surround mechanisms of initiation and propagation, the localization of fibrinolysis reactions to the fibrin clot, and the influence of fibrin structure and clot composition on thrombolysis. This review covers these key areas with a focus on recent developments on fibrin structure and binding, the effects of a variety of cell types, the consequences of histones and DNA released by neutrophils, and the influence of flow. A complete understanding of the regulation of fibrinolysis will come from the building of detailed mathematical models. Suitable models are at an early stage of development, but may improve as model clots increase in complexity to incorporate the components and interactions listed above.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CPB2Humanfibrinolysis pathway   TAS  RGD 
Cpb2Ratfibrinolysis pathway   ISOCPB2 (Homo sapiens) RGD 
Cpb2Mousefibrinolysis pathway   ISOCPB2 (Homo sapiens) RGD 
FGAHumanfibrinolysis pathway   TAS  RGD 
FGBHumanfibrinolysis pathway   TAS  RGD 
FGGHumanfibrinolysis pathway   TAS  RGD 
FgaRatfibrinolysis pathway   ISOFGA (Homo sapiens) RGD 
FgaMousefibrinolysis pathway   ISOFGA (Homo sapiens) RGD 
FgbRatfibrinolysis pathway   ISOFGB (Homo sapiens) RGD 
FgbMousefibrinolysis pathway   ISOFGB (Homo sapiens) RGD 
FggRatfibrinolysis pathway   ISOFGG (Homo sapiens) RGD 
FggMousefibrinolysis pathway   ISOFGG (Homo sapiens) RGD 
PLATHumanfibrinolysis pathway   TAS  RGD 
PLAUHumanfibrinolysis pathway   TAS  RGD 
PLGHumanfibrinolysis pathway   TAS  RGD 
PlatRatfibrinolysis pathway   ISOPLAT (Homo sapiens) RGD 
PlatMousefibrinolysis pathway   ISOPLAT (Homo sapiens) RGD 
PlauRatfibrinolysis pathway   ISOPLAU (Homo sapiens) RGD 
PlauMousefibrinolysis pathway   ISOPLAU (Homo sapiens) RGD 
PlgRatfibrinolysis pathway   ISOPLG (Homo sapiens) RGD 
PlgMousefibrinolysis pathway   ISOPLG (Homo sapiens) RGD 
SERPINA5Humanfibrinolysis pathway   TAS  RGD 
SERPINB2Humanfibrinolysis pathway   TAS  RGD 
SERPINE1Humanfibrinolysis pathway   TAS  RGD 
SERPINE2Humanfibrinolysis pathway   TAS  RGD 
SERPINF2Humanfibrinolysis pathway   TAS  RGD 
Serpina5Ratfibrinolysis pathway   ISOSERPINA5 (Homo sapiens) RGD 
Serpina5Mousefibrinolysis pathway   ISOSERPINA5 (Homo sapiens) RGD 
Serpinb2Ratfibrinolysis pathway   ISOSERPINB2 (Homo sapiens) RGD 
Serpinb2Mousefibrinolysis pathway   ISOSERPINB2 (Homo sapiens) RGD 
Serpine1Ratfibrinolysis pathway   ISOSERPINE1 (Homo sapiens) RGD 
Serpine1Mousefibrinolysis pathway   ISOSERPINE1 (Homo sapiens) RGD 
Serpine2Ratfibrinolysis pathway   ISOSERPINE2 (Homo sapiens) RGD 
Serpine2Mousefibrinolysis pathway   ISOSERPINE2 (Homo sapiens) RGD 
Serpinf2Ratfibrinolysis pathway   ISOSERPINF2 (Homo sapiens) RGD 
Serpinf2Mousefibrinolysis pathway   ISOSERPINF2 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Cpb2  (carboxypeptidase B2)
Fga  (fibrinogen alpha chain)
Fgb  (fibrinogen beta chain)
Fgg  (fibrinogen gamma chain)
Plat  (plasminogen activator, tissue type)
Plau  (plasminogen activator, urokinase)
Plg  (plasminogen)
Serpina5  (serpin family A member 5)
Serpinb2  (serpin family B member 2)
Serpine1  (serpin family E member 1)
Serpine2  (serpin family E member 2)
Serpinf2  (serpin family F member 2)

Genes (Mus musculus)
Cpb2  (carboxypeptidase B2)
Fga  (fibrinogen alpha chain)
Fgb  (fibrinogen beta chain)
Fgg  (fibrinogen gamma chain)
Plat  (plasminogen activator, tissue)
Plau  (plasminogen activator, urokinase)
Plg  (plasminogen)
Serpina5  (serine (or cysteine) peptidase inhibitor, clade A, member 5)
Serpinb2  (serine (or cysteine) peptidase inhibitor, clade B, member 2)
Serpine1  (serine (or cysteine) peptidase inhibitor, clade E, member 1)
Serpine2  (serine (or cysteine) peptidase inhibitor, clade E, member 2)
Serpinf2  (serine (or cysteine) peptidase inhibitor, clade F, member 2)

Genes (Homo sapiens)
CPB2  (carboxypeptidase B2)
FGA  (fibrinogen alpha chain)
FGB  (fibrinogen beta chain)
FGG  (fibrinogen gamma chain)
PLAT  (plasminogen activator, tissue type)
PLAU  (plasminogen activator, urokinase)
PLG  (plasminogen)
SERPINA5  (serpin family A member 5)
SERPINB2  (serpin family B member 2)
SERPINE1  (serpin family E member 1)
SERPINE2  (serpin family E member 2)
SERPINF2  (serpin family F member 2)


Additional Information