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Gene: Gclc (glutamate-cysteine ligase, catalytic subunit) Rattus norvegicus
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Description: Exhibits glutamate-cysteine ligase activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and cellular response to mechanical stimulus. Localizes to glutamate-cysteine ligase complex. Used to study liver cirrhosis and pulmonary emphysema. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine ligase deficiency; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit); PARTICIPATES IN glutathione metabolic pathway; 2-hydroxyglutaric aciduria pathway; cysteine metabolic pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 1,1'-azobis(N,N-dimethylformamide).
Type: protein-coding
Also known as: gamma-ECS; gamma-glutamylcysteine synthetase; GCS heavy chain; Glclc; glutamate--cysteine ligase catalytic subunit; glutamate-cysteine ligase catalytic subunit; Glutamylcysteine gamma synthetase light chain; MGC93096
Homo sapiens (human) : GCLC (glutamate-cysteine ligase catalytic subunit)  HGNC  Alliance
Mus musculus (house mouse) : Gclc (glutamate-cysteine ligase, catalytic subunit)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gclc (glutamate-cysteine ligase catalytic subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : GCLC (glutamate-cysteine ligase catalytic subunit)
Canis lupus familiaris (dog) : GCLC (glutamate-cysteine ligase catalytic subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gclc (glutamate-cysteine ligase catalytic subunit)
Sus scrofa (pig) : GCLC (glutamate-cysteine ligase catalytic subunit)
Chlorocebus sabaeus (African green monkey) : GCLC (glutamate-cysteine ligase catalytic subunit)
Heterocephalus glaber (naked mole-rat) : Gclc (glutamate-cysteine ligase catalytic subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0885,059,051 - 85,097,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,059,051 - 85,097,468 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0884,627,768 - 84,666,188 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4882,724,429 - 82,762,848 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1882,743,482 - 82,781,899 (+)NCBI
Celera878,379,669 - 78,418,088 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gclc
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619868
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.