Abcb11 (ATP binding cassette subfamily B member 11) - Rat Genome Database

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Gene: Abcb11 (ATP binding cassette subfamily B member 11) Rattus norvegicus
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Symbol: Abcb11
Name: ATP binding cassette subfamily B member 11
RGD ID: 619930
Description: Enables ABC-type xenobiotic transporter activity; bile acid transmembrane transporter activity; and carbohydrate transmembrane transporter activity. Involved in several processes, including canalicular bile acid transport; xenobiotic export from cell; and xenobiotic transmembrane transport. Located in Golgi membrane; intracellular canaliculus; and recycling endosome membrane. Used to study cholestasis. Biomarker of alcoholic hepatitis and cholestasis. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11); PARTICIPATES IN statin pharmacokinetics pathway; bile acid transport pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (S)-colchicine; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; ATP-binding cassette, subfamily B (MDR/TAP), member 11; bile salt export pump; Bsep; sister of P-glycoprotein; Spgp
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Abcb11em1Sage  
Genetic Models: SD-Abcb11em1Sage
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,424,620 - 74,520,646 (-)NCBIGRCr8
mRatBN7.2354,016,854 - 54,112,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl354,017,127 - 54,112,730 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx357,417,556 - 57,512,821 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0366,001,112 - 66,096,389 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,763,287 - 63,858,864 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,480,024 - 55,587,946 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,480,024 - 55,587,946 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0362,091,490 - 62,092,502 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0362,106,821 - 62,195,528 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera353,579,155 - 53,674,029 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(S)-colchicine  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)ethanone  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP)
17beta-estradiol 3-glucosiduronic acid  (EXP)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
3'-phospho-5'-adenylyl sulfate  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene  (ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (EXP)
8-Epidiosbulbin E acetate  (ISO)
acadesine  (EXP,ISO)
acetamide  (EXP)
aconitine  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
albuterol  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-linolenic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP,ISO)
amitriptyline  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
amprenavir  (ISO)
angelicin  (EXP)
ANTIMYCIN  (ISO)
arachidonic acid  (ISO)
astemizole  (ISO)
atazanavir sulfate  (ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
ATP  (EXP,ISO)
atropine  (ISO)
Augmentin  (ISO)
aurantio-obtusin  (ISO)
azathioprine  (EXP)
benzbromarone  (ISO)
benziodarone  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Boldine  (EXP)
bosentan  (EXP,ISO)
bromfenac  (ISO)
bucladesine  (EXP)
budesonide  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
calcein am  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
Carboxyatractyloside  (ISO)
carvedilol  (ISO)
cefaclor  (ISO)
cefalotin  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
cetirizine  (ISO)
cetrorelix  (ISO)
CGP 52608  (ISO)
chelerythrine  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlordiazepoxide  (ISO)
chloroform  (EXP)
chlorpromazine  (EXP,ISO)
cholate  (ISO)
cholesterol  (ISO)
cholic acid  (EXP,ISO)
choline  (ISO)
chrysophanol  (EXP)
ciglitazone  (ISO)
cinnarizine  (ISO)
ciprofibrate  (ISO)
cisapride  (ISO)
clarithromycin  (ISO)
clavulanic acid  (ISO)
clofazimine  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clotrimazole  (ISO)
cloxacillin  (EXP,ISO)
clozapine  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
Cryptotanshinone  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP)
danazol  (ISO)
DDE  (ISO)
dehydroepiandrosterone sulfate  (ISO)
deoxycholic acid  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diclofenac  (ISO)
dicloxacillin  (ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (EXP)
dihydroergotamine  (ISO)
Dihydrotanshinone I  (ISO)
Diosbulbin B  (ISO)
dioscin  (EXP)
dioxygen  (ISO)
dipyridamole  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dobutamine  (ISO)
dorsomorphin  (EXP,ISO)
doxycycline  (EXP)
drospirenone  (ISO)
drotaverine  (ISO)
efavirenz  (ISO)
emodin  (EXP,ISO)
enilconazole  (ISO)
epoxiconazole  (EXP)
ergocristine  (ISO)
erythromycin A  (ISO)
erythromycin estolate  (EXP,ISO)
ethambutol  (ISO)
ethanol  (EXP,ISO)
etoricoxib  (ISO)
everolimus  (ISO)
ezetimibe  (ISO)
felodipine  (ISO)
fenofibrate  (EXP,ISO)
Fexofenadine hydrochloride  (EXP,ISO)
finasteride  (ISO)
flucloxacillin  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
fluvoxamine  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
fusidic acid  (EXP,ISO)
gallocatechin  (ISO)
gefitinib  (ISO)
gentamycin  (EXP)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (EXP,ISO)
glafenine  (EXP)
glimepiride  (ISO)
glipizide  (ISO)
glyburide  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
Goe 6976  (EXP)
guggulsterone  (EXP,ISO)
GW 4064  (EXP,ISO)
Heliotrine  (ISO)
ibuprofen  (ISO)
icariside II  (ISO)
iloperidone  (ISO)
imipenem hydrate  (ISO)
indinavir  (ISO)
indocyanine green  (ISO)
indometacin  (ISO)
irbesartan  (ISO)
isobavachalcone  (ISO)
isoniazide  (EXP,ISO)
Isradipine  (ISO)
itraconazole  (ISO)
ivacaftor  (EXP)
kansuinin B  (ISO)
ketoconazole  (ISO)
kynurenic acid  (ISO)
L-methionine  (ISO)
lapatinib  (ISO)
Lasiocarpine  (ISO)
latanoprost  (ISO)
lipopolysaccharide  (EXP,ISO)
liquiritin  (ISO)
lithocholic acid  (ISO)
loperamide  (ISO)
lopinavir  (ISO)
loratadine  (ISO)
losartan  (ISO)
lovastatin  (ISO)
Maprotiline  (EXP)
medroxyprogesterone acetate  (ISO)
megestrol acetate  (ISO)
menadione  (ISO)
Mesaconitine  (ISO)
metformin  (EXP,ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methimazole  (ISO)
methoxsalen  (EXP)
methylisothiazolinone  (ISO)
methyltestosterone  (ISO)
metronidazole  (ISO)
Mibefradil  (ISO)
midazolam  (ISO)
Midecamycin  (EXP,ISO)
mifepristone  (ISO)
MK 571  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morin  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester  (ISO)
N-nitrosodiethylamine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naproxen  (ISO)
nefazodone  (EXP,ISO)
nelfinavir  (ISO)
neomycin  (ISO)
neratinib  (ISO)
nicardipine  (ISO)
nifedipine  (ISO)
nitrendipine  (ISO)
nitrofen  (EXP)
nitrofurantoin  (ISO)
norethisterone  (ISO)
notoginsenoside R1  (EXP,ISO)
O-methyleugenol  (ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (EXP)
octreotide  (ISO)
ofloxacin  (ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP)
olmesartan  (ISO)
Olmesartan medoxomil  (ISO)
oltipraz  (ISO)
omeprazole  (ISO)
oxybutynin  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
pazopanib  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (EXP)
phalloidin  (EXP)
phenobarbital  (ISO)
phosphatidylcholine  (ISO)
physcion  (EXP)
Picroside ii  (ISO)
Pilsicainide hydrochloride  (ISO)
pimecrolimus  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
posaconazole  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
primaquine  (ISO)
primidone  (ISO)
prochloraz  (EXP)
procymidone  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
psoralen  (EXP)
pyrazinecarboxamide  (EXP,ISO)
quercetin  (EXP,ISO)
ranolazine  (ISO)
Repaglinide  (ISO)
reserpine  (ISO)
Rhein  (ISO)
rifabutin  (ISO)
rifampicin  (EXP,ISO)
rifamycin SV  (ISO)
rifapentine  (ISO)
ritonavir  (ISO)
rosuvastatin calcium  (EXP,ISO)
Salidroside  (ISO)
saquinavir  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silibinin  (EXP)
simvastatin  (EXP,ISO)
simvastatin hydroxy acid  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sorafenib  (ISO)
soybean oil  (EXP)
spironolactone  (ISO)
staurosporine  (ISO)
stigmasterol  (ISO)
streptozocin  (EXP,ISO)
sulfamethoxazole  (ISO)
sulfinpyrazone  (ISO)
Sunset Yellow FCF  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (EXP,ISO)
tasosartan  (ISO)
taurine  (EXP)
tauro-beta-muricholic acid  (EXP)
taurochenodeoxycholic acid  (EXP,ISO)
taurocholic acid  (EXP,ISO)
taurodeoxycholic acid  (EXP,ISO)
taurolithocholic acid  (EXP,ISO)
tauroursodeoxycholic acid  (EXP,ISO)
tebuconazole  (ISO)
tectorigenin  (ISO)
telithromycin  (ISO)
telmisartan  (ISO)
Temsirolimus  (ISO)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (EXP)
ticlopidine  (EXP,ISO)
tinidazole  (ISO)
tipranavir  (ISO)
tolcapone  (ISO)
tolvaptan  (ISO)
toosendanin  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
UDP-alpha-D-glucuronic acid  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valinomycin  (ISO)
valproic acid  (EXP,ISO)
valrubicin  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (ISO)
vitamin E  (ISO)
wortmannin  (EXP,ISO)
Yangonin  (ISO)
zafirlukast  (ISO)
zidovudine  (EXP)
zinc acetate  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Diagnosis of cirrhosis in patients with chronic hepatitis C genotype 4: Role of ABCB11 genotype polymorphism and plasma bile acid levels. Besheer T, etal., Turk J Gastroenterol. 2018 May;29(3):299-307. doi: 10.5152/tjg.2018.17570.
2. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Cai SY, etal., Gastroenterology. 2009 Mar;136(3):1060-9. doi: 10.1053/j.gastro.2008.10.025. Epub 2008 Nov 1.
3. Role of polymorphic bile salt export pump (BSEP, ABCB11) transporters in anti-tuberculosis drug-induced liver injury in a Chinese cohort. Chen R, etal., Sci Rep. 2016 Jun 13;6:27750. doi: 10.1038/srep27750.
4. Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats. Crocenzi FA, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G449-59. Epub 2003 Apr 17.
5. Influence of ABCB11 and HNF4α genes on daclatasvir plasma concentration: preliminary pharmacogenetic data from the Kineti-C study. Cusato J, etal., J Antimicrob Chemother. 2017 Oct 1;72(10):2846-2849. doi: 10.1093/jac/dkx237.
6. Metabolic preconditioning protects BSEP/ABCB11-/- mice against cholestatic liver injury. Fuchs CD, etal., J Hepatol. 2017 Jan;66(1):95-101. doi: 10.1016/j.jhep.2016.08.017. Epub 2016 Sep 1.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Functional analysis of the rat bile salt export pump gene promoter. Gerloff T, etal., Eur J Biochem 2002 Jul;269(14):3495-503.
9. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. Gerloff T, etal., J Biol Chem 1998 Apr 17;273(16):10046-50.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Short-chain ubiquitination is associated with the degradation rate of a cell-surface-resident bile salt export pump (BSEP/ABCB11). Hayashi H and Sugiyama Y, Mol Pharmacol. 2009 Jan;75(1):143-50. doi: 10.1124/mol.108.049288. Epub 2008 Oct 1.
12. Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep. Hayashi H, etal., Biochim Biophys Acta. 2005 Dec 30;1738(1-3):54-62. doi: 10.1016/j.bbalip.2005.10.006. Epub 2005 Nov 15.
13. AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function. Hayashi H, etal., Hepatology. 2012 Jun;55(6):1889-900. doi: 10.1002/hep.25591.
14. Hepatic overexpression of abcb11 promotes hypercholesterolemia and obesity in mice. Henkel AS, etal., Gastroenterology. 2011 Oct;141(4):1404-11, 1411.e1-2. doi: 10.1053/j.gastro.2011.06.062. Epub 2011 Jul 2.
15. Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. Hirano M, etal., J Pharmacol Exp Ther. 2005 Aug;314(2):876-82. Epub 2005 May 18.
16. LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes. Homolya L, etal., PLoS One. 2014 Mar 18;9(3):e91921. doi: 10.1371/journal.pone.0091921. eCollection 2014.
17. Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump (BSEP/ABCB11). Kato T, etal., Biochim Biophys Acta. 2010 Sep;1801(9):1005-12. doi: 10.1016/j.bbalip.2010.04.002. Epub 2010 Apr 14.
18. Newly synthesized canalicular ABC transporters are directly targeted from the Golgi to the hepatocyte apical domain in rat liver. Kipp H and Arias IM, J Biol Chem. 2000 May 26;275(21):15917-25.
19. Transporters on demand: intrahepatic pools of canalicular ATP binding cassette transporters in rat liver. Kipp H, etal., J Biol Chem. 2001 Mar 9;276(10):7218-24. doi: 10.1074/jbc.M007794200. Epub 2000 Dec 11.
20. Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase. Kubitz R, etal., Gastroenterology. 2004 Feb;126(2):541-53.
21. Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats. Li X, etal., Arch Toxicol. 2017 Jan;91(1):481-494. doi: 10.1007/s00204-016-1697-8. Epub 2016 Apr 18.
22. Adenovirus-mediated human aquaporin-1 expression in hepatocytes improves lipopolysaccharide-induced cholestasis. Marrone J, etal., IUBMB Life. 2017 Dec;69(12):978-984. doi: 10.1002/iub.1689. Epub 2017 Oct 31.
23. Involvement of multiple efflux transporters in hepatic disposition of fexofenadine. Matsushima S, etal., Mol Pharmacol. 2008 May;73(5):1474-83. doi: 10.1124/mol.107.041459. Epub 2008 Feb 1.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells. Mochizuki K, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G818-28. doi: 10.1152/ajpgi.00415.2006. Epub 2006 Nov 2.
26. Changes in the expression of genes related to bile acid synthesis and transport by the rat liver during hepatocarcinogenesis. Monte MJ, etal., Clin Sci (Lond). 2005 Aug;109(2):199-207.
27. A frequent variant in the human bile salt export pump gene ABCB11 is associated with hepatitis C virus infection, but not liver stiffness in a German population. Müllenbach R, etal., BMC Gastroenterol. 2012 Jun 8;12:63. doi: 10.1186/1471-230X-12-63.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. Ortiz DF, etal., J Biol Chem 2004 Jul 30;279(31):32761-70. Epub 2004 May 24.
31. Differences in presentation and progression between severe FIC1 and BSEP deficiencies. Pawlikowska L, etal., J Hepatol. 2010 Jul;53(1):170-8. doi: 10.1016/j.jhep.2010.01.034. Epub 2010 Apr 13.
32. Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failure in isolated rat hepatocyte couplets: a role for protein kinase C and prevention by protein kinase A. Perez LM, etal., Toxicol Sci. 2006 May;91(1):150-8. Epub 2006 Feb 1.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. GOA pipeline RGD automated data pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. A novel mutation within a transmembrane helix of the bile salt export pump (BSEP, ABCB11) with delayed development of cirrhosis. Stindt J, etal., Liver Int. 2013 Nov;33(10):1527-35. doi: 10.1111/liv.12217. Epub 2013 Jun 12.
38. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Strautnieks SS, etal., Nat Genet. 1998 Nov;20(3):233-8.
39. Tsumura-Suzuki obese diabetic mice-derived hepatic tumors closely resemble human hepatocellular carcinomas in metabolism-related genes expression and bile acid accumulation. Takahashi T, etal., Hepatol Int. 2018 May;12(3):254-261. doi: 10.1007/s12072-018-9860-3. Epub 2018 Apr 12.
40. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
41. Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Vos TA, etal., Hepatology. 1998 Dec;28(6):1637-44.
42. Intracellular trafficking of bile salt export pump (ABCB11) in polarized hepatic cells: constitutive cycling between the canalicular membrane and rab11-positive endosomes. Wakabayashi Y, etal., Mol Biol Cell. 2004 Jul;15(7):3485-96. doi: 10.1091/mbc.e03-10-0737. Epub 2004 Apr 30.
43. The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II. Wang L, etal., J Clin Invest. 2002 Oct;110(7):965-72.
44. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
45. Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins. Yabuuchi H, etal., Biopharm Drug Dispos. 2008 Nov;29(8):441-8. doi: 10.1002/bdd.629.
46. Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice. Zhang Y, etal., J Biol Chem. 2012 Jul 13;287(29):24784-94. doi: 10.1074/jbc.M111.329318. Epub 2012 May 22.
Additional References at PubMed
PMID:11279518   PMID:12068294   PMID:12538788   PMID:15040800   PMID:15763547   PMID:17384956   PMID:17615179   PMID:17855769   PMID:17916651   PMID:17947449   PMID:18551070   PMID:19056867  
PMID:20147439   PMID:20702406   PMID:21748767   PMID:22057277   PMID:23096566   PMID:23108811   PMID:23200860   PMID:23376485   PMID:24002920   PMID:26646631   PMID:27237619   PMID:28645914  
PMID:30068870   PMID:31746430  


Genomics

Comparative Map Data
Abcb11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,424,620 - 74,520,646 (-)NCBIGRCr8
mRatBN7.2354,016,854 - 54,112,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl354,017,127 - 54,112,730 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx357,417,556 - 57,512,821 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0366,001,112 - 66,096,389 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,763,287 - 63,858,864 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,480,024 - 55,587,946 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,480,024 - 55,587,946 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0362,091,490 - 62,092,502 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0362,106,821 - 62,195,528 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera353,579,155 - 53,674,029 (-)NCBICelera
Cytogenetic Map3q21NCBI
ABCB11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382168,915,390 - 169,031,324 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2168,915,498 - 169,031,324 (-)EnsemblGRCh38hg38GRCh38
GRCh372169,777,291 - 169,887,834 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,487,695 - 169,596,079 (-)NCBINCBI36Build 36hg18NCBI36
Build 342169,604,955 - 169,713,340NCBI
Celera2163,404,770 - 163,513,162 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2161,675,981 - 161,784,996 (-)NCBIHuRef
CHM1_12169,785,291 - 169,893,825 (-)NCBICHM1_1
T2T-CHM13v2.02169,389,027 - 169,507,061 (-)NCBIT2T-CHM13v2.0
Abcb11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,068,626 - 69,172,960 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl269,068,626 - 69,172,958 (-)EnsemblGRCm39 Ensembl
GRCm38269,238,282 - 69,342,616 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,238,282 - 69,342,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,076,339 - 69,180,673 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36269,039,121 - 69,143,426 (-)NCBIMGSCv36mm8
Celera270,904,503 - 71,008,403 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map239.69NCBI
Abcb11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,412,876 - 5,512,701 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,412,958 - 5,511,629 (+)NCBIChiLan1.0ChiLan1.0
ABCB11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21371,579,415 - 71,699,912 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B71,594,388 - 71,714,885 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B56,199,434 - 56,311,773 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B173,664,518 - 173,776,233 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,664,518 - 173,776,379 (-)Ensemblpanpan1.1panPan2
ABCB11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,742,895 - 13,835,312 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,746,964 - 13,834,974 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,757,951 - 13,834,638 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03613,859,241 - 13,951,551 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3613,861,592 - 13,951,309 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13613,948,052 - 14,024,630 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03613,935,894 - 14,012,502 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03614,048,864 - 14,125,753 (-)NCBIUU_Cfam_GSD_1.0
Abcb11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303131,017,599 - 131,107,385 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646910,521,576 - 10,599,005 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646910,521,576 - 10,599,005 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCB11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,402,396 - 75,486,403 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,402,296 - 75,487,092 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,505,249 - 84,590,184 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCB11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11054,458,283 - 54,575,943 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1054,459,377 - 54,575,059 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040144,979,703 - 145,077,569 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcb11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247876,650,772 - 6,733,195 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247876,653,849 - 6,733,058 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abcb11
683 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:36
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000075107
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat

Markers in Region
D18061  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2354,017,159 - 54,017,235 (+)MAPPERmRatBN7.2
Rnor_6.0355,480,056 - 55,480,131NCBIRnor6.0
Rnor_5.0362,091,522 - 62,091,597UniSTSRnor5.0
Celera353,579,187 - 53,579,262UniSTS


Genetic Models
This gene Abcb11 is modified in the following models/strains:
SD-Abcb11em1Sage    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 27 27 27
Low 2 24 8 19 8 2 2 1 10 6 7 2
Below cutoff 1 7 6 6 6 6 6 32 9 21 4 6

Sequence


Ensembl Acc Id: ENSRNOT00000075107   ⟹   ENSRNOP00000064279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl354,017,128 - 54,112,730 (-)Ensembl
Rnor_6.0 Ensembl355,480,024 - 55,587,946 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104145   ⟹   ENSRNOP00000084310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl354,017,127 - 54,100,973 (-)Ensembl
RefSeq Acc Id: NM_031760   ⟹   NP_113948
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,424,980 - 74,520,581 (-)NCBI
mRatBN7.2354,017,128 - 54,112,730 (-)NCBI
Rnor_6.0355,480,024 - 55,587,946 (-)NCBI
Rnor_5.0362,091,490 - 62,092,502 (-)NCBI
Rnor_5.0362,106,821 - 62,195,528 (-)NCBI
Celera353,579,155 - 53,674,029 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105931   ⟹   XP_038961859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,424,620 - 74,520,646 (-)NCBI
mRatBN7.2354,016,854 - 54,112,797 (-)NCBI
RefSeq Acc Id: XM_039105932   ⟹   XP_038961860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,424,620 - 74,520,629 (-)NCBI
mRatBN7.2354,016,854 - 54,112,780 (-)NCBI
RefSeq Acc Id: XM_039105933   ⟹   XP_038961861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8374,424,620 - 74,503,721 (-)NCBI
mRatBN7.2354,016,854 - 54,095,865 (-)NCBI
RefSeq Acc Id: NP_113948   ⟸   NM_031760
- UniProtKB: O70127 (UniProtKB/Swiss-Prot),   A0A2P1EA62 (UniProtKB/TrEMBL),   M0R4J2 (UniProtKB/TrEMBL),   O88331 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064279   ⟸   ENSRNOT00000075107
RefSeq Acc Id: XP_038961859   ⟸   XM_039105931
- Peptide Label: isoform X1
- UniProtKB: O70127 (UniProtKB/Swiss-Prot),   A0A2P1EA62 (UniProtKB/TrEMBL),   M0R4J2 (UniProtKB/TrEMBL),   O88331 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961860   ⟸   XM_039105932
- Peptide Label: isoform X1
- UniProtKB: O70127 (UniProtKB/Swiss-Prot),   A0A2P1EA62 (UniProtKB/TrEMBL),   M0R4J2 (UniProtKB/TrEMBL),   O88331 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961861   ⟸   XM_039105933
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZYZ3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084310   ⟸   ENSRNOT00000104145
Protein Domains
ABC transmembrane type-1   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70127-F1-model_v2 AlphaFold O70127 1-1321 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692112
Promoter ID:EPDNEW_R2637
Type:initiation region
Name:Abcb11_1
Description:ATP binding cassette subfamily B member 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0355,587,960 - 55,588,020EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619930 AgrOrtholog
BioCyc Gene G2FUF-49512 BioCyc
Ensembl Genes ENSRNOG00000050860 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055023634 UniProtKB/Swiss-Prot
  ENSRNOG00060003171 UniProtKB/Swiss-Prot
  ENSRNOG00065016450 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000075107 UniProtKB/TrEMBL
  ENSRNOT00000075107.3 UniProtKB/Swiss-Prot
  ENSRNOT00000104145.1 UniProtKB/TrEMBL
  ENSRNOT00055040726 UniProtKB/Swiss-Prot
  ENSRNOT00060005254 UniProtKB/Swiss-Prot
  ENSRNOT00065027401 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type_I_exporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83569 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 83569 ENTREZGENE
PANTHER ALPHA-FACTOR-TRANSPORTING ATPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ABCB11 RGD
PhenoGen Abcb11 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050860 RatGTEx
  ENSRNOG00055023634 RatGTEx
  ENSRNOG00060003171 RatGTEx
  ENSRNOG00065016450 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2P1EA62 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYZ3 ENTREZGENE, UniProtKB/TrEMBL
  ABCBB_RAT UniProtKB/Swiss-Prot
  M0R4J2 ENTREZGENE, UniProtKB/TrEMBL
  O70127 ENTREZGENE
  O88331 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Abcb11  ATP binding cassette subfamily B member 11  Abcb11  ATP-binding cassette, subfamily B (MDR/TAP), member 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcb11  ATP-binding cassette, subfamily B (MDR/TAP), member 11  Abcb11  ATP-binding cassette, sub-family B (MDR/TAP), member 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Abcb11  ATP-binding cassette, sub-family B (MDR/TAP), member 11      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Abcb11  ATP-binding cassette, sub-family B (MDR/TAP), member 11      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to hepatocyte canalicular microvilli and to subcanalicular vesicles 728120
gene_disease impairment of the function causes cholestasis due to inherited mutations of its gene 625722
gene_expression expression reduced in response to certain types of liver damage 70249
gene_expression highly expressed in the canalicular membrane of hepatocytes 625722
gene_homology closely related to P-glycoprotein, the gene product of Mdr1a/1b 625722
gene_process involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes 724707
gene_product member of the superfamily of ATP-binding cassette (ABC) transporters 625722
gene_protein 160 kDa 625722
gene_regulation transport activity is inhibited by vanadate 728120
gene_regulation farnesoid X receptor (FXR) regulates activation due to bile acid feed-back 625722
gene_transcript 5 region contains multiple binding sites for the liver enriched transcription factor HNF3, one HNF1 site, multiple AP1 sites , three consensus motifs for C/EBP- binding elements and two binding sites for the FXR/9-cis-retinoic acid receptor heterodimer 625722