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Gene: Abcb11 (ATP binding cassette subfamily B member 11) Rattus norvegicus
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Symbol: Abcb11
Name: ATP binding cassette subfamily B member 11
Description: Exhibits canalicular bile acid transmembrane transporter activity and carbohydrate transmembrane transporter activity. Involved in several processes, including canalicular bile acid transport; drug export; and response to estrogen. Localizes to the Golgi membrane and apical plasma membrane. Used to study cholestasis. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11); PARTICIPATES IN statin pharmacokinetics pathway; bile acid transport pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (S)-colchicine; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; ATP-binding cassette, subfamily B (MDR/TAP), member 11; bile salt export pump; Bsep; sister of P-glycoprotein; Spgp
Orthologs:
Homo sapiens (human) : ABCB11 (ATP binding cassette subfamily B member 11)  HGNC  Alliance
Mus musculus (house mouse) : Abcb11 (ATP-binding cassette, sub-family B (MDR/TAP), member 11)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Abcb11 (ATP binding cassette subfamily B member 11)
Pan paniscus (bonobo/pygmy chimpanzee) : ABCB11 (ATP binding cassette subfamily B member 11)
Canis lupus familiaris (dog) : ABCB11 (ATP binding cassette subfamily B member 11)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Abcb11 (ATP binding cassette subfamily B member 11)
Sus scrofa (pig) : ABCB11 (ATP binding cassette subfamily B member 11)
more info ...
Allele / Splice: Abcb11em1Sage  
Genetic Models: SD-Abcb11em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0355,480,024 - 55,587,946 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0362,091,490 - 62,092,502 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0362,106,821 - 62,195,528 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera353,579,155 - 53,674,029 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Abcb11
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619930
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.