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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619930
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb11
Name: ATP binding cassette subfamily B member 11
Acc ID: CHEBI:16359
Term: cholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.
Chemical ID: MESH:D019826
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb11increases expressionEXP 6480464CTDCholic Acid results in increased expression of ABCB11 mRNAPMID:14684380
Abcb11multiple interactionsEXP 6480464CTD[Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of ABCB11 mRNAPMID:14684380
Abcb11decreases activityISOABCB11 (Homo sapiens)6480464CTDCholic Acid results in decreased activity of ABCB11 proteinPMID:24014644
Abcb11increases expressionISOABCB11 (Homo sapiens)6480464CTDCholic Acid results in increased expression of ABCB11 mRNAPMID:25055961
Abcb11increases expressionISOAbcb11 (Mus musculus)6480464CTDCholic Acid results in increased expression of ABCB11 mRNA; Cholic Acid results in increased expression of ABCB11 proteinPMID:11438506 PMID:12971955 PMID:15466244 PMID:15694933 PMID:22961653 PMID:25582706
Abcb11multiple interactionsISOABCB11 (Homo sapiens)6480464CTDCholic Acid inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]PMID:24014644
Abcb11multiple interactionsISOAbcb11 (Mus musculus)6480464CTD[Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [NR1H4 protein mutant form inhibits the reaction [Cholic Acid results in increased phosphorylation of NR1H4 protein]] which results in decreased expression of ABCB11 mRNA; epiallopregnanolone sulfate inhibits the reaction [Cholic Acid results in increased expression of ABCB11 mRNA]PMID:22540009 PMID:22961653 PMID:30996006
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