GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcb11 | increases expression | EXP | | 6480464 | CTD | Cholic Acid results in increased expression of ABCB11 mRNA | PMID:14684380 | Abcb11 | multiple interactions | EXP | | 6480464 | CTD | [Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of ABCB11 mRNA | PMID:14684380 | Abcb11 | decreases activity | ISO | ABCB11 (Homo sapiens) | 6480464 | CTD | Cholic Acid results in decreased activity of ABCB11 protein | PMID:24014644 | Abcb11 | increases expression | ISO | ABCB11 (Homo sapiens) | 6480464 | CTD | Cholic Acid results in increased expression of ABCB11 mRNA | PMID:25055961 | Abcb11 | increases expression | ISO | Abcb11 (Mus musculus) | 6480464 | CTD | Cholic Acid results in increased expression of ABCB11 mRNA; Cholic Acid results in increased expression of ABCB11 protein | PMID:11438506 PMID:12971955 PMID:15466244 PMID:15694933 PMID:22961653 PMID:25582706 | Abcb11 | multiple interactions | ISO | ABCB11 (Homo sapiens) | 6480464 | CTD | Cholic Acid inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] | PMID:24014644 | Abcb11 | multiple interactions | ISO | Abcb11 (Mus musculus) | 6480464 | CTD | [Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [NR1H4 protein mutant form inhibits the reaction [Cholic Acid results in increased phosphorylation of NR1H4 protein]] which results in decreased expression of ABCB11 mRNA; epiallopregnanolone sulfate inhibits the reaction [Cholic Acid results in increased expression of ABCB11 mRNA] | PMID:22540009 PMID:22961653 PMID:30996006 | |
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