Hrtrt4 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Hrtrt4 (Heart rate QTL 4) Rattus norvegicus

Symbol: Hrtrt4
Name: Heart rate QTL 4
RGD ID: 1300178
Previously known as: Hr4; SCOR25; Specialized Center of Research QTL 19, 25; SCOR19
Trait: heart pumping trait   (VT:2000009)    
Measurement Type: heart rate   (CMO:0000002)    
LOD Score: 3.74
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8351,490,129 - 111,359,995RGD_MAPPER_PIPELINE
mRatBN7.2343,827,364 - 90,905,114RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0345,406,058 - 94,467,785RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0350,522,686 - 101,095,668RGDRnor5.0
RGSC_v3.4341,054,012 - 89,859,652RGDRGSC3.4
RGSC_v3.1340,950,385 - 89,756,143RGD
Cross Type: Not Available
Strains Crossed: BN/SsNHsd SS/JrHsdMcwi 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hrtrt4Ratheart disease  IAGP 727992 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hrtrt4Ratabnormal heart rate  QTM 727992 RGD 
Hrtrt4Ratincreased heart rate  IAGP 727992 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hrtrt4Ratheart rate  IDA 727992 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hrtrt4Ratcontrolled sodium content diet  IDA 727992 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hrtrt4Ratvascular indwelling catheter method  IDA 727992 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hrtrt4RatBN/SsNHsd  IEA 727992 RGD 
Hrtrt4RatSS/JrHsdMcwi  IEA 727992 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hrtrt4Ratheart pumping trait  IDA 727992 RGD 


#
Reference Title
Reference Citation
1. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Moreno C, etal., Physiol Genomics 2003 Nov 11;15(3):243-57. Epub 2003 Oct 07.


1 to 20 of 806 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1307840Pkp4plakophilin 434363236443835834Rat
41094759Rps14-ps3ribosomal protein S14, pseudogene 334387634543876799Rat
9190663LOC103691811dynein light chain roadblock-type 1 pseudogene34388464343885168Rat
1309610Dapl1death associated protein-like 134396099343980940Rat
41255996LOC120101955U6 spliceosomal RNA34404418944044292Rat
1302949Tanc1tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 134409938744335478Rat
1359296Wdsub1WD repeat, sterile alpha motif and U-box domain containing 134434041544370890Rat
11422397LOC108350580uncharacterized LOC10835058034437592444379414Rat
1309801Baz2bbromodomain adjacent to zinc finger domain, 2B34438428244681619Rat
7716591Arf4-ps1ADP-ribosylation factor 4, pseudogene 134462585044630139Rat
41047996Rnu6-22RNA, U6 small nuclear 2234466084744660953Rat
1308993Marchf7membrane associated ring-CH-type finger 734468022944720172Rat
41254171LOC120101908uncharacterized LOC12010190834470164544705078Rat
1307606Cd302CD302 molecule34472232444756045Rat
7489036Mir6216microRNA 621634475686144756938Rat
41332538LOC120101907uncharacterized LOC12010190734476111544773503Rat
1565962Ly75lymphocyte antigen 7534476470244852219Rat
1309777Pla2r1phospholipase A2 receptor 134488394345013793Rat
1303119Itgb6integrin subunit beta 634504629545170532Rat
41106923LOC120102123U4 spliceosomal RNA34513767345137755Rat

1 to 20 of 806 rows
1 to 20 of 713 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
41780D3Rat22714734382736443827511Ratregion
5041784RH12905716234383566843835830Ratregion
728032D3Chm7923434383707443837310Ratregion
41908D3Rat27521534408420044084415Ratregion
36472D3Rat4413134418827844188411Ratregion
40362D3Rat18716234419364344193805Ratregion
1638291D3Got26715134421274944212900Ratregion
5067002AU04802320734431673944316948Ratregion
5044066RH13039018434433273344332917Ratregion
5055293RH14371811934433281044332929Ratregion
5089553AU04922320934438338944383598Ratregion
5076222RH13905014334438452644384669Ratregion
5056345RH14432511234438514044385252Ratregion
42643D3Rat27420334445632444456527Ratregion
1633847D3Got24412634451633744516463Ratregion
5501904MARC_17149-17150:1028234160:136234459259544592957Ratregion
5084970AA80033016434460252444602688Ratregion
5073256RH13733120534472239544722600Ratregion
5072208RH13671516134476477444764935Ratregion
37394D3Rat12322734480510444805331Ratregion
1 to 20 of 713 rows

Flank 1: (D3Rat227)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2343,827,364 - 43,827,511 (+)MAPPER
Rnor_6.0345,406,058 - 45,406,204NCBI
Rnor_5.0350,522,686 - 50,522,832UniSTS
RGSC_v3.4341,054,013 - 41,054,159UniSTS
RGSC_v3.4341,054,012 - 41,054,159RGD
RGSC_v3.1340,950,385 - 40,950,531RGD
Celera341,876,124 - 41,876,270UniSTS
RH 3.4 Map3562.6RGD
RH 3.4 Map3562.6UniSTS
RH 2.0 Map3341.5RGD
SHRSP x BN Map330.1998RGD
Cytogenetic Map3q21UniSTS
Peak: (D3Rat180)
Rat AssemblyChrPosition (strand)Source
GRCr8381,425,008 - 81,425,116 (+)Marker Load Pipeline
mRatBN7.2361,017,749 - 61,017,857 (+)MAPPER
Rnor_6.0362,922,868 - 62,922,975NCBI
Rnor_5.0369,467,333 - 69,467,440UniSTS
RGSC_v3.4358,764,514 - 58,764,621UniSTS
RGSC_v3.4358,764,506 - 58,764,827RGD
RGSC_v3.1358,660,878 - 58,661,199RGD
Celera360,517,624 - 60,517,731UniSTS
SHRSP x BN Map338.3798UniSTS
SHRSP x BN Map338.3798RGD
Cytogenetic Map3q23UniSTS
Flank 2: (D3Rat168)
Rat AssemblyChrPosition (strand)Source
GRCr83111,359,809 - 111,359,995 (+)Marker Load Pipeline
mRatBN7.2390,904,932 - 90,905,114 (+)MAPPER
Rnor_6.0394,467,600 - 94,467,785NCBI
Rnor_5.03101,095,483 - 101,095,668UniSTS
RGSC_v3.4389,859,465 - 89,859,652RGD
RGSC_v3.4389,859,466 - 89,859,651UniSTS
RGSC_v3.1389,755,726 - 89,756,143RGD
Celera389,965,663 - 89,965,848UniSTS
RH 3.4 Map3736.6UniSTS
RH 3.4 Map3736.6RGD
SHRSP x BN Map347.3398UniSTS
SHRSP x BN Map347.3398RGD


1 to 10 of 85 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)32749462144188411Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat

1 to 10 of 85 rows


Database
Acc Id
Source(s)
NCBI Gene Hrtrt4


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-04-14 Hrtrt4  Heart rate QTL 4  Hr4    Symbol updated 1299863 APPROVED

Note Type Note Reference
qtl_general additional information, including phenotype and mapping information, can be found at Genomic Map of Cardiovascular Phenotypes 727992
qtl_general mean heart rate averaged over 3 hours from rats on high salt diet (SCOR25) 727992
qtl_general significant linkage also found at this locus to heart rate from the basal state, with the lights on and the rat asleep (SCOR19, LOD=3.54) 727992