Or4c105b (olfactory receptor family 4 subfamily C member 105B) - Rat Genome Database

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Gene: Or4c105b (olfactory receptor family 4 subfamily C member 105B) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Or4c105b
Name: olfactory receptor family 4 subfamily C member 105B
RGD ID: 1334412
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be active in plasma membrane; INTERACTS WITH indole-3-methanol; N-acetyl-L-cysteine; N-nitrosodiethylamine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 653; olfactory receptor gene Olr653; olfactory receptor Olr653; Olr653
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8394,914,483 - 94,915,412 (+)NCBIGRCr8
mRatBN7.2374,458,280 - 74,459,209 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl374,455,596 - 74,467,433 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx377,824,654 - 77,825,583 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0386,423,200 - 86,424,129 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0384,253,642 - 84,254,571 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0377,151,061 - 77,153,354 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl377,152,425 - 77,197,011 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0383,861,996 - 83,862,925 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4372,772,283 - 72,773,212 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1372,668,654 - 72,669,584 (+)NCBI
Celera373,718,010 - 73,718,939 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or4c105bRatindole-3-methanol multiple interactionsEXP 6480464[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR4C105B mRNACTDPMID:22129741
Or4c105bRatN-acetyl-L-cysteine multiple interactionsEXP 6480464[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR4C105B mRNACTDPMID:22129741
Or4c105bRatN-nitrosodiethylamine multiple interactionsEXP 6480464[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of OR4C105B mRNACTDPMID:22129741
Or4c105bRatvinclozolin decreases methylationEXP 6480464vinclozolin results in decreased methylation of OR4C105B geneCTDPMID:31079544


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or4c105bRatdetection of chemical stimulus involved in sensory perception of smell  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or4c105bRatdetection of chemical stimulus involved in sensory perception of smell involved_inIEAGO:00049841600115GO_REF:0000108GOCGO_REF:0000108
Or4c105bRatG protein-coupled receptor signaling pathway  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or4c105bRatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or4c105bRatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or4c105bRatsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043
Or4c105bRatsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or4c105bRatmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Or4c105bRatmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Or4c105bRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Or4c105bRatplasma membrane is_active_inIBAMGI:3030568 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Or4c105bRatplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Or4c105bRatplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or4c105bRatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or4c105bRatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Or4c105bRatolfactory receptor activity  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or4c105bRatolfactory receptor activity enablesIEAInterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or4c105bRatolfactory receptor activity enablesIBAMGI:3030568 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or4c105bRattaste/olfaction phenotype  IEA 1303377 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Or4c105b
3 total Variants

1 to 10 of 41 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat

1 to 10 of 41 rows



ectoderm
nervous system
reproductive system
1 1 1


RefSeq Transcripts NM_001000637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000082255   ⟹   ENSRNOP00000071719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl377,152,425 - 77,197,011 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092045   ⟹   ENSRNOP00000069525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl377,152,425 - 77,153,465 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117667   ⟹   ENSRNOP00000091213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl374,455,596 - 74,467,433 (+)Ensembl
RefSeq Acc Id: NM_001000637   ⟹   NP_001000637
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8394,914,483 - 94,915,412 (+)NCBI
mRatBN7.2374,458,280 - 74,459,209 (+)NCBI
Rnor_6.0377,152,425 - 77,153,354 (+)NCBI
Rnor_5.0383,861,996 - 83,862,925 (+)NCBI
RGSC_v3.4372,772,283 - 72,773,212 (+)RGD
Celera373,718,010 - 73,718,939 (+)RGD
Sequence:
Protein RefSeqs NP_001000637 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091213.1
  ENSRNOP00000101473
RefSeq Acc Id: NP_001000637   ⟸   NM_001000637
- UniProtKB: A0A8I6AEV3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069525   ⟸   ENSRNOT00000092045
Ensembl Acc Id: ENSRNOP00000071719   ⟸   ENSRNOT00000082255
Ensembl Acc Id: ENSRNOP00000091213   ⟸   ENSRNOT00000117667
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVK9-F1-model_v2 AlphaFold A0A0G2JVK9 1-309 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-48879 BioCyc
Ensembl Genes ENSRNOG00000057654 Ensembl
  ENSRNOG00000068529 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000089765 ENTREZGENE
Ensembl Transcript ENSRNOT00000117667.1 UniProtKB/TrEMBL
  ENSRNOT00000166911 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_Receptors UniProtKB/TrEMBL
KEGG Report rno:404830 UniProtKB/TrEMBL
NCBI Gene 404830 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or4c105b PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057654 RatGTEx
  ENSRNOG00000068529 RatGTEx
  ENSRNOG00000089765 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6AEV3 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or4c105b  olfactory receptor family 4 subfamily C member 105B  Olr653  olfactory receptor 653  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr653  olfactory receptor 653   Olr653_predicted  olfactory receptor 653 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr653_predicted  olfactory receptor 653 (predicted)      Symbol and Name status set to approved 70820 APPROVED