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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

Authors: Gibbs, RA  Weinstock, GM  Metzker, ML  Muzny, DM  Sodergren, EJ  Scherer, S  Scott, G  Steffen, D  Worley, KC  Burch, PE  Okwuonu, G  Hines, S  Lewis, L  DeRamo, C  Delgado, O  Dugan-Rocha, S  Miner, G  Morgan, M  Hawes, A  Gill, R  Celera, R  Holt, RA  Adams, MD  Amanatides, PG  Baden-Tillson, H  Barnstead, M  Chin, S  Evans, CA  Ferriera, S  Fosler, C  Glodek, A  Gu, Z  Jennings, D  Kraft, CL  Nguyen, T  Pfannkoch, CM  Sitter, C  Sutton, GG  Venter, JC  Woodage, T  Smith, D  Lee, HM  Gustafson, E  Cahill, P  Kana, A  Doucette-Stamm, L  Weinstock, K  Fechtel, K  Weiss, RB  Dunn, DM  Green, ED  Blakesley, RW  Bouffard, GG  De Jong, PJ  Osoegawa, K  Zhu, B  Marra, M  Schein, J  Bosdet, I  Fjell, C  Jones, S  Krzywinski, M  Mathewson, C  Siddiqui, A  Wye, N  McPherson, J  Zhao, S  Fraser, CM  Shetty, J  Shatsman, S  Geer, K  Chen, Y  Abramzon, S  Nierman, WC  Havlak, PH  Chen, R  Durbin, KJ  Egan, A  Ren, Y  Song, XZ  Li, B  Liu, Y  Qin, X  Cawley, S  Worley, Kim C  Cooney, A J  D'Souza, Lisa M  Martin, Kirt  Wu, Jia Qian  Gonzalez-Garay, Manuel L  Jackson, Andrew R  Kalafus, Kenneth J  McLeod, Michael P  Milosavljevic, Aleksandar  Virk, Davinder  Volkov, Andrei  Wheeler, David A  Zhang, Zhengdong  Bailey, Jeffrey A  Eichler, Evan E  Tuzun, Eray  Birney, Ewan  Mongin, Emmanuel  Ureta-Vidal, Abel  Woodwark, Cara  Zdobnov, Evgeny  Bork, Peer  Suyama, Mikita  Torrents, David  Alexandersson, Marina  Trask, Barbara J  Young, Janet M  Huang, Hui  Wang, Huajun  Xing, Heming  Daniels, Sue  Gietzen, Darryl  Schmidt, Jeanette  Stevens, Kristian  Vitt, Ursula  Wingrove, Jim  Camara, Francisco  Mar Albà, M  Abril, Josep F  Guigo, Roderic  Smit, Arian  Dubchak, Inna  Rubin, Edward M  Couronne, Olivier  Poliakov, Alexander  Hübner, Norbert  Ganten, Detlev  Goesele, Claudia  Hummel, Oliver  Kreitler, Thomas  Lee, Young-Ae  Monti, Jan  Schulz, Herbert  Zimdahl, Heike  Himmelbauer, Heinz  Lehrach, Hans  Jacob, Howard J  Bromberg, Susan  Gullings-Handley, Jo  Jensen-Seaman, Michael I  Kwitek, Anne E  Lazar, Jozef  Pasko, Dean  Tonellato, Peter J  Twigger, Simon  Ponting, Chris P  Duarte, Jose M  Rice, Stephen  Goodstadt, Leo  Beatson, Scott A  Emes, Richard D  Winter, Eitan E  Webber, Caleb  Brandt, Petra  Nyakatura, Gerald  Adetobi, Margaret  Chiaromonte, Francesca  Elnitski, Laura  Eswara, Pallavi  Hardison, Ross C  Hou, Minmei  Kolbe, Diana  Makova, Kateryna  Miller, Webb  Nekrutenko, Anton  Riemer, Cathy  Schwartz, Scott  Taylor, James  Yang, Shan  Zhang, Yi  Lindpaintner, Klaus  Andrews, T Dan  Caccamo, Mario  Clamp, Michele  Clarke, Laura  Curwen, Valerie  Durbin, Richard  Eyras, Eduardo  Searle, Stephen M  Cooper, Gregory M  Batzoglou, Serafim  Brudno, Michael  Sidow, Arend  Stone, Eric A  Venter, J Craig  Payseur, Bret A  Bourque, Guillaume  López-Otín, Carlos  Puente, Xose S  Chakrabarti, Kushal  Chatterji, Sourav  Dewey, Colin  Pachter, Lior  Bray, Nicolas  Yap, Von Bing  Caspi, Anat  Tesler, Glenn  Pevzner, Pavel A  Haussler, David  Roskin, Krishna M  Baertsch, Robert  Clawson, Hiram  Furey, Terrence S  Hinrichs, Angie S  Karolchik, Donna  Kent, William J  Rosenbloom, Kate R  Trumbower, Heather  Weirauch, Matt  Cooper, David N  Stenson, Peter D  Ma, Bin  Brent, Michael  Arumugam, Manimozhiyan  Shteynberg, David  Copley, Richard R  Taylor, Martin S  Riethman, Harold  Mudunuri, Uma  Peterson, Jane  Guyer, Mark  Felsenfeld, Adam  Old, Susan  Mockrin, Stephen  Collins, Francis  Collins, Francis 
Citation: Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
Pubmed: (View Article at PubMed) PMID:15057822
DOI: Full-text: DOI:10.1038/nature02426

The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.

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RGD Object Information
RGD ID: 1303377
Created: 2004-12-09
Species: All species
Last Modified: 2004-12-09
Status: ACTIVE



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