Or4e2 (olfactory receptor family 4 subfamily E member 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Or4e2 (olfactory receptor family 4 subfamily E member 5) Rattus norvegicus
Analyze
Symbol: Or4e2
Name: olfactory receptor family 4 subfamily E member 5
RGD ID: 1334073
Description: Predicted to enable copper ion binding activity; odorant binding activity; and olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human OR4E2 (olfactory receptor family 4 subfamily E member 2); INTERACTS WITH bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); 3,4-methylenedioxymethamphetamine (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1643; olfactory receptor gene Olr1643; olfactory receptor Olr1643; Olr1643
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,661,127 - 27,662,053 (+)NCBIGRCr8
mRatBN7.21525,187,633 - 25,188,559 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1525,179,800 - 25,191,297 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,958,514 - 27,959,440 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,914,407 - 28,915,333 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01527,167,349 - 27,168,275 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,894,627 - 28,895,553 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,894,627 - 28,895,553 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,725,888 - 32,726,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,928,940 - 27,929,866 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,944,639 - 27,945,566 (+)NCBI
Celera1525,487,893 - 25,488,819 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IBA,ISO)
plasma membrane  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22328155   PMID:25185561   PMID:25901328   PMID:27019154   PMID:29659735  


Genomics

Comparative Map Data
Or4e2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,661,127 - 27,662,053 (+)NCBIGRCr8
mRatBN7.21525,187,633 - 25,188,559 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1525,179,800 - 25,191,297 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,958,514 - 27,959,440 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,914,407 - 28,915,333 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01527,167,349 - 27,168,275 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,894,627 - 28,895,553 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,894,627 - 28,895,553 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,725,888 - 32,726,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,928,940 - 27,929,866 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,944,639 - 27,945,566 (+)NCBI
Celera1525,487,893 - 25,488,819 (+)NCBICelera
Cytogenetic Map15p14NCBI
OR4E2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381421,653,835 - 21,667,642 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1421,653,835 - 21,667,642 (+)EnsemblGRCh38hg38GRCh38
GRCh371422,122,051 - 22,135,856 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361421,203,137 - 21,204,078 (+)NCBINCBI36Build 36hg18NCBI36
Build 341421,203,136 - 21,204,078NCBI
Celera141,996,670 - 1,997,611 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef142,251,000 - 2,251,941 (+)NCBIHuRef
CHM1_11422,132,985 - 22,133,926 (+)NCBICHM1_1
T2T-CHM13v2.01415,851,493 - 15,865,307 (+)NCBIT2T-CHM13v2.0
Or4e2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391452,687,850 - 52,688,859 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1452,680,447 - 52,690,031 (+)EnsemblGRCm39 Ensembl
GRCm381452,450,393 - 52,451,402 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1452,442,990 - 52,452,574 (+)EnsemblGRCm38mm10GRCm38
MGSCv371453,070,068 - 53,071,077 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361451,372,366 - 51,373,292 (+)NCBIMGSCv36mm8
Celera1449,441,578 - 49,442,587 (+)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1426.95NCBI
LOC102015989
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555502,352,164 - 2,353,090 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555502,352,164 - 2,353,090 (+)NCBIChiLan1.0ChiLan1.0
LOC100980776
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21523,108,915 - 23,122,545 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11422,325,401 - 22,339,031 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0142,474,364 - 2,475,305 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11420,591,011 - 20,591,952 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1420,591,011 - 20,591,952 (+)Ensemblpanpan1.1panPan2
OR4H12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11517,321,371 - 17,322,875 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1517,321,380 - 17,322,309 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1517,782,171 - 17,783,019 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01517,576,432 - 17,577,362 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11517,261,551 - 17,262,480 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01517,313,717 - 17,314,646 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01517,441,528 - 17,442,457 (-)NCBIUU_Cfam_GSD_1.0
LOC101974914
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864032,869,625 - 32,870,551 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936976415,720 - 416,646 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936976415,720 - 416,646 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100510915
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl777,528,181 - 77,529,122 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1777,528,181 - 77,529,122 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2782,869,105 - 82,870,046 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103231435
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12922,087,016 - 22,089,274 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2922,087,726 - 22,088,667 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605924,334,806 - 24,336,394 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101702732
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248257,646,103 - 7,647,044 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Or4e2
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:81
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000017795
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
nervous system
reproductive system
respiratory system
4 3 1 4 10 1

Sequence


Ensembl Acc Id: ENSRNOT00000017795   ⟹   ENSRNOP00000017795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1528,894,627 - 28,895,553 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112245   ⟹   ENSRNOP00000088210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1525,179,803 - 25,191,297 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114496   ⟹   ENSRNOP00000088987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1525,179,800 - 25,191,297 (+)Ensembl
RefSeq Acc Id: NM_001000535   ⟹   NP_001000535
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,661,127 - 27,662,053 (+)NCBI
mRatBN7.21525,187,633 - 25,188,559 (+)NCBI
Rnor_6.01528,894,627 - 28,895,553 (+)NCBI
Rnor_5.01532,725,888 - 32,726,814 (+)NCBI
RGSC_v3.41527,928,940 - 27,929,866 (+)RGD
Celera1525,487,893 - 25,488,819 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000535 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88487 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000088210.1
  ENSRNOP00000088987.1
RefSeq Acc Id: NP_001000535   ⟸   NM_001000535
- UniProtKB: D4ADC0 (UniProtKB/TrEMBL),   A6KEI2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017795   ⟸   ENSRNOT00000017795
Ensembl Acc Id: ENSRNOP00000088210   ⟸   ENSRNOT00000112245
Ensembl Acc Id: ENSRNOP00000088987   ⟸   ENSRNOT00000114496
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADC0-F1-model_v2 AlphaFold D4ADC0 1-308 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1334073 AgrOrtholog
BioCyc Gene G2FUF-13966 BioCyc
Ensembl Genes ENSRNOG00000013338 Ensembl
  ENSRNOG00000063163 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000112245.1 UniProtKB/TrEMBL
  ENSRNOT00000114496.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_Receptors UniProtKB/TrEMBL
KEGG Report rno:364306 UniProtKB/TrEMBL
NCBI Gene 364306 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 4Q2 UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or4e2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013338 RatGTEx
  ENSRNOG00000063163 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6KEI2 ENTREZGENE, UniProtKB/TrEMBL
  D4ADC0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or4e2  olfactory receptor family 4 subfamily E member 5  Olr1643  olfactory receptor 1643  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1643  olfactory receptor 1643   Olr1643_predicted  olfactory receptor 1643 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1643_predicted  olfactory receptor 1643 (predicted)      Symbol and Name status set to approved 70820 APPROVED