Or52e5b (olfactory receptor family 52 subfamily E member 5B) - Rat Genome Database

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Gene: Or52e5b (olfactory receptor family 52 subfamily E member 5B) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Or52e5b
Name: olfactory receptor family 52 subfamily E member 5B
RGD ID: 1333390
Description: Predicted to enable G protein-coupled receptor activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 189; olfactory receptor gene Olr189; olfactory receptor Olr189; Olr189; ratchr1-162938513-162939454_ORF
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81168,871,628 - 168,874,819 (+)NCBIGRCr8
mRatBN7.21159,461,887 - 159,462,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1159,459,779 - 159,463,265 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1167,469,866 - 167,470,807 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01174,655,824 - 174,656,765 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01167,546,863 - 167,547,804 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01169,951,913 - 169,952,854 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1169,951,913 - 169,952,854 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01176,966,521 - 176,967,462 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41162,843,036 - 162,843,977 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11162,938,512 - 162,939,454 (+)NCBI
Celera1157,400,036 - 157,400,977 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or52e5bRatdetection of chemical stimulus involved in sensory perception of smell involved_inIEAGO:00049841600115GO_REF:0000108GOCGO_REF:0000108
Or52e5bRatdetection of chemical stimulus involved in sensory perception of smell  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or52e5bRatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or52e5bRatG protein-coupled receptor signaling pathway  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or52e5bRatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or52e5bRatsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043
Or52e5bRatsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or52e5bRatmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Or52e5bRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Or52e5bRatmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Or52e5bRatplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Or52e5bRatplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or52e5bRatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or52e5bRatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Or52e5bRatolfactory receptor activity enablesIEAInterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or52e5bRatolfactory receptor activity  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or52e5bRattaste/olfaction phenotype  IEA 1303377 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline


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Variants in Or52e5b
9 total Variants

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:47
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000040861
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 77 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat

1 to 10 of 77 rows
UniSTS:495355  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21159,429,321 - 159,430,352 (+)MAPPERmRatBN7.2
mRatBN7.21159,461,825 - 159,462,856 (+)MAPPERmRatBN7.2
Rnor_6.01169,951,852 - 169,952,882NCBIRnor6.0
Rnor_5.01176,966,460 - 176,967,490UniSTSRnor5.0
RGSC_v3.41162,842,975 - 162,844,005UniSTSRGSC3.4
Celera1157,399,975 - 157,401,005UniSTS
Cytogenetic Map1q33UniSTS







Ensembl Acc Id: ENSRNOT00000040861   ⟹   ENSRNOP00000048359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1169,951,913 - 169,952,854 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000050034   ⟹   ENSRNOP00000044204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1159,459,779 - 159,463,265 (+)Ensembl
RefSeq Acc Id: NM_001000184   ⟹   NP_001000184
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,873,746 - 168,874,687 (+)NCBI
mRatBN7.21159,461,887 - 159,462,828 (+)NCBI
Rnor_6.01169,951,913 - 169,952,854 (+)NCBI
Rnor_5.01176,966,521 - 176,967,462 (+)NCBI
RGSC_v3.41162,843,036 - 162,843,977 (+)RGD
Celera1157,400,036 - 157,400,977 (+)RGD
Sequence:
RefSeq Acc Id: XM_063285529   ⟹   XP_063141599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81168,871,628 - 168,874,819 (+)NCBI
Protein RefSeqs NP_001000184 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141599 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044204
  ENSRNOP00000044204.2
RefSeq Acc Id: NP_001000184   ⟸   NM_001000184
- UniProtKB: D3ZXV7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000048359   ⟸   ENSRNOT00000040861
Ensembl Acc Id: ENSRNOP00000044204   ⟸   ENSRNOT00000050034
RefSeq Acc Id: XP_063141599   ⟸   XM_063285529
- Peptide Label: isoform X1
- UniProtKB: D3ZXV7 (UniProtKB/TrEMBL)
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAJ3-F1-model_v2 AlphaFold D3ZAJ3 1-313 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-58042 BioCyc
Ensembl Genes ENSRNOG00000049717 Ensembl
  ENSRNOG00000068326 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000084589 ENTREZGENE
Ensembl Transcript ENSRNOT00000050034 ENTREZGENE
  ENSRNOT00000050034.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_rcpt UniProtKB/TrEMBL
KEGG Report rno:293333 UniProtKB/TrEMBL
NCBI Gene 293333 ENTREZGENE
PANTHER OLFACTORY RECEPTOR 52E5 UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 56B1-RELATED UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or52e5b PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049717 RatGTEx
  ENSRNOG00000068326 RatGTEx
  ENSRNOG00000084589 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt D3ZXV7 ENTREZGENE, UniProtKB/TrEMBL
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or52e5b  olfactory receptor family 52 subfamily E member 5B  Olr189  olfactory receptor 189  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr189  olfactory receptor 189   Olr189_predicted  olfactory receptor 189 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr189_predicted  olfactory receptor 189 (predicted)      Symbol and Name status set to approved 70820 APPROVED