Or5h25b (olfactory receptor family 5 subfamily H member 25B) - Rat Genome Database

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Gene: Or5h25b (olfactory receptor family 5 subfamily H member 25B) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Or5h25b (Ensembl: Or5h26b)
Name: olfactory receptor family 5 subfamily H member 25B (Ensembl:olfactory receptor family 5 subfamily H member 26B)
RGD ID: 1333347
Description: Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Orthologous to several human genes including OR5H1 (olfactory receptor family 5 subfamily H member 1); INTERACTS WITH vinclozolin.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1545; olfactory receptor gene Olr1545; olfactory receptor Olr1545; Olr1545
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81154,802,315 - 54,803,238 (+)NCBIGRCr8
mRatBN7.21141,333,112 - 41,334,035 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1141,333,106 - 41,334,035 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1141,239,764 - 41,244,036 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1150,062,231 - 50,063,154 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01142,733,521 - 42,734,444 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,862,160 - 41,863,083 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01143,431,431 - 43,432,354 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,431,431 - 43,432,354 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01146,618,151 - 46,619,073 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41142,133,334 - 42,134,257 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11142,190,922 - 42,191,846 (+)NCBI
Celera1141,145,144 - 41,146,067 (+)NCBICelera
Cytogenetic Map11q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or5h25bRatvinclozolin decreases expressionEXP 6480464vinclozolin results in decreased expression of OR5H25B mRNACTDPMID:22615374


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or5h25bRatdetection of chemical stimulus involved in sensory perception of smell involved_inIEAGO:00049841600115GO_REF:0000108GOCGO_REF:0000108
Or5h25bRatdetection of chemical stimulus involved in sensory perception of smell  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or5h25bRatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or5h25bRatG protein-coupled receptor signaling pathway  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or5h25bRatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or5h25bRatsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043
Or5h25bRatsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or5h25bRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Or5h25bRatmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Or5h25bRatplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Or5h25bRatplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or5h25bRatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Or5h25bRatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Or5h25bRatodorant binding enablesIBAMGI:3030853 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Or5h25bRatolfactory receptor activity enablesIEAInterPro:IPR0007251600115GO_REF:0000002InterProGO_REF:0000002
Or5h25bRatolfactory receptor activity  IEA (All species)1303377CREATED_DATE field changed to comply with GOC standards. Original CREATED_DATE: 2005-02-17RGD 
Or5h25bRatolfactory receptor activity enablesIBAMGI:3030069 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Or5h25bRattaste/olfaction phenotype  IEA 1303377 RGD 

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Or5h25b
5 total Variants

1 to 10 of 18 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
11528648Bss118Bone structure and strength QTL 1186.6582e-07femur strength trait (VT:0010010)femur ultimate displacement (CMO:0002719)114063876343376331Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat

1 to 10 of 18 rows





RefSeq Transcripts NM_001001105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC144660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000081261   ⟹   ENSRNOP00000075636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1141,239,764 - 41,244,036 (+)Ensembl
Rnor_6.0 Ensembl1143,431,431 - 43,432,354 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096970   ⟹   ENSRNOP00000088765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1141,333,106 - 41,334,035 (+)Ensembl
RefSeq Acc Id: NM_001001105   ⟹   NP_001001105
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81154,802,315 - 54,803,238 (+)NCBI
mRatBN7.21141,333,112 - 41,334,035 (+)NCBI
Rnor_6.01143,431,431 - 43,432,354 (+)NCBI
Rnor_5.01146,618,151 - 46,619,073 (+)NCBI
RGSC_v3.41142,133,334 - 42,134,257 (+)RGD
Celera1141,145,144 - 41,146,067 (+)RGD
Sequence:
Protein RefSeqs NP_001001105 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000088765
  ENSRNOP00000088765.1
RefSeq Acc Id: NP_001001105   ⟸   NM_001001105
- UniProtKB: A0A8I6GHE6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075636   ⟸   ENSRNOT00000081261
Ensembl Acc Id: ENSRNOP00000088765   ⟸   ENSRNOT00000096970
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KB34-F1-model_v2 AlphaFold A0A0G2KB34 1-307 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-21597 BioCyc
Ensembl Genes ENSRNOG00000055575 Ensembl
  ENSRNOG00000064197 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000067575 Ensembl
  ENSRNOG00000071849 ENTREZGENE
Ensembl Transcript ENSRNOT00000096970 ENTREZGENE
  ENSRNOT00000096970.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
NCBI Gene 406001 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or5h25b PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055575 RatGTEx
  ENSRNOG00000064197 RatGTEx
  ENSRNOG00000067575 RatGTEx
  ENSRNOG00000071849 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6GHE6 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or5h25b  olfactory receptor family 5 subfamily H member 25B  Olr1545  olfactory receptor 1545  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1545  olfactory receptor 1545   Olr1545_predicted  olfactory receptor 1545 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1545_predicted  olfactory receptor 1545 (predicted)      Symbol and Name status set to approved 70820 APPROVED