Or5h25b (olfactory receptor family 5 subfamily H member 25B) - Rat Genome Database

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Gene: Or5h25b (olfactory receptor family 5 subfamily H member 25B) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Or5h25b
Name: olfactory receptor family 5 subfamily H member 25B
RGD ID: 1333347
Description: Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Orthologous to human OR5H1 (olfactory receptor family 5 subfamily H member 1) and OR5H2 (olfactory receptor family 5 subfamily H member 2); INTERACTS WITH vinclozolin.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1545; olfactory receptor gene Olr1545; olfactory receptor Olr1545; Olr1545
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81154,802,315 - 54,803,238 (+)NCBIGRCr8
mRatBN7.21141,333,112 - 41,334,035 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1141,333,106 - 41,334,035 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1141,239,764 - 41,244,036 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1150,062,231 - 50,063,154 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01142,733,521 - 42,734,444 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,862,160 - 41,863,083 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01143,431,431 - 43,432,354 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,431,431 - 43,432,354 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01146,618,151 - 46,619,073 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41142,133,334 - 42,134,257 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11142,190,922 - 42,191,846 (+)NCBI
Celera1141,145,144 - 41,146,067 (+)NCBICelera
Cytogenetic Map11q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Or5h25b
5 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000081261   ⟹   ENSRNOP00000075636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1141,239,764 - 41,244,036 (+)Ensembl
Rnor_6.0 Ensembl1143,431,431 - 43,432,354 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096970   ⟹   ENSRNOP00000088765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1141,333,106 - 41,334,035 (+)Ensembl
RefSeq Acc Id: NM_001001105   ⟹   NP_001001105
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81154,802,315 - 54,803,238 (+)NCBI
mRatBN7.21141,333,112 - 41,334,035 (+)NCBI
Rnor_6.01143,431,431 - 43,432,354 (+)NCBI
Rnor_5.01146,618,151 - 46,619,073 (+)NCBI
RGSC_v3.41142,133,334 - 42,134,257 (+)RGD
Celera1141,145,144 - 41,146,067 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001001105 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000088765
  ENSRNOP00000088765.1
Reference Protein Sequences
RefSeq Acc Id: NP_001001105   ⟸   NM_001001105
- UniProtKB: A0A8I6GHE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075636   ⟸   ENSRNOT00000081261
RefSeq Acc Id: ENSRNOP00000088765   ⟸   ENSRNOT00000096970
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KB34-F1-model_v2 AlphaFold A0A0G2KB34 1-307 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333347 AgrOrtholog
BioCyc Gene G2FUF-21597 BioCyc
Ensembl Genes ENSRNOG00000055575 Ensembl
  ENSRNOG00000064197 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000067575 Ensembl
Ensembl Transcript ENSRNOT00000096970 ENTREZGENE
  ENSRNOT00000096970.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
NCBI Gene 406001 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or5h25b PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055575 RatGTEx
  ENSRNOG00000064197 RatGTEx
  ENSRNOG00000067575 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6GHE6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or5h25b  olfactory receptor family 5 subfamily H member 25B  Olr1545  olfactory receptor 1545  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1545  olfactory receptor 1545   Olr1545_predicted  olfactory receptor 1545 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1545_predicted  olfactory receptor 1545 (predicted)      Symbol and Name status set to approved 70820 APPROVED