Iddm17 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Iddm17 (Insulin dependent diabetes mellitus QTL 17) Rattus norvegicus

Symbol: Iddm17
Name: Insulin dependent diabetes mellitus QTL 17
RGD ID: 724554
Previously known as: Iddm/kdp1
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: blood glucose level   (CMO:0000046)    
LOD Score: Not Available
P Value: 0.001
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81146,443,168 - 91,443,168RGD_MAPPER_PIPELINE
mRatBN7.21118,976,208 - 86,241,447RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01119,016,272 - 90,463,843RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01122,660,494 - 93,518,069RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41119,445,919 - 87,759,784RGDRGSC3.4
RGSC_v3.11119,445,919 - 87,800,381RGD
Cross Type: backcross
Strains Crossed: TM KDP/Tky 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm17RatChronic Pancreatitis  IDA 634732 RGD 
Iddm17Rattype 1 diabetes mellitus  IDA 634732 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm17Ratpancreas inflammation  QTM 634732 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm17Ratblood glucose level  IDA 634732 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm17Ratspecific pathogen-free condition  IDA 634732 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm17Ratblood glucose test strip  IDA 634732 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm17RatKDP/Tky  IEA 634732 RGD 
Iddm17RatTM  IEA 634732 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm17Ratblood glucose amount  IDA 634732 RGD 


#
Reference Title
Reference Citation
1. A non-MHC locus essential for autoimmune type I diabetes in the Komeda Diabetes-Prone rat. Yokoi N, etal., J Clin Invest 1997 Oct 15;100(8):2015-21.


1 to 20 of 958 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
41115113LOC120095718U6 spliceosomal RNA111957838019578477Rat
1597984Pcbp2-ps8poly(rC) binding protein 2, pseudogene 8111969395819697409Rat
1303131Ncam2neural cell adhesion molecule 2112010497420592168Rat
6499722Tmem258-ps5transmembrane protein 258, pseudogene 5112060280420603028Rat
1586138Pes1-ps1pescadillo ribosomal biogenesis factor 1, pseudogene 1112153064721532896Rat
1583562LOC681129triosephosphate isomerase 1 pseudogene112204586522046777Rat
7499203LOC102551587uncharacterized LOC102551587112209068322134713Rat
1583549Rpl32-ps15ribosomal protein L32, pseudogene 15112229514722295534Rat
41054117LOC120095600uncharacterized LOC120095600112246683022530379Rat
1587389Eno1-ps22enolase 1, pseudogene 22112253904522541205Rat
11400799LOC108352387H/ACA ribonucleoprotein complex subunit 3 pseudogene112257400922574422Rat
41257749LOC120095802U4 spliceosomal RNA112287406422874217Rat
40969201LOC120095601uncharacterized LOC120095601112357849723607404Rat
41401168LOC120095602uncharacterized LOC120095602112362682523639139Rat
2324553Tmem126a-ps3transmembrane protein 126A, pseudogene 3112366809823671133Rat
10045371Mir155hgMir155 host gene112377346823775697Rat
7489038Mir155microRNA 155112377465423774718Rat
1591507Mrpl39mitochondrial ribosomal protein L39112377965523795146Rat
41165047LOC120095730small nucleolar RNA SNORA70112379736523797457Rat
1561692Jam2junctional adhesion molecule 2112383082023880071Rat

1 to 20 of 958 rows
1 to 20 of 1222 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10375D11Mgh1149118256655382566702Ratregion
10376D11Wox6173118256654582566718Ratregion
10911D11Wox3184115543703355437217Ratregion
11026D11Wox9153113708449637084649Ratregion
11044D11Wox5246118344055583440803Ratregion
33792D11Mit2262113015999530160257Ratregion
33899D11Mit494112183661521836709Ratregion
34003D11Mit3134112627791326278047Ratregion
34112D11Mgh4172115980262259802794Ratregion
34130D11Mgh6100111897620818976310Ratregion
34725D11Mgh3168116642214866422316Ratregion
34727D11Mgh9147116297952662979675Ratregion
11291D11Mgh7162117757016877570330Ratregion
11292D11Got72144117757022577570369Ratregion
11343D11Wox2144117695623676956380Ratregion
11344D11Arb1223117695623576956458Ratregion
33642D11Mit1123113491804134918164Ratregion
33642D11Mit1123113491804134918164Ratregion
36065D11Rat6152114428575944285911Ratregion
36095D11Rat7161114545932345459484Ratregion
1 to 20 of 1222 rows

Flank 1: (D11Mit8)
Rat AssemblyChrPosition (strand)Source
RH 3.4 Map11642.9RGD
RH 3.4 Map11642.9UniSTS
RH 2.0 Map1164.4RGD
SHRSP x BN Map1135.7599RGD
FHH x ACI Map1155.0699RGD
Cytogenetic Map11q23UniSTS
Peak: (D11Wox3)
Rat AssemblyChrPosition (strand)Source
GRCr81168,943,076 - 68,943,260 (+)Marker Load Pipeline
mRatBN7.21155,437,033 - 55,437,217 (+)MAPPER
Rnor_6.01160,397,957 - 60,398,140NCBI
Rnor_5.01164,500,538 - 64,500,721UniSTS
RGSC_v3.41156,973,743 - 56,973,927RGD
RGSC_v3.41156,973,744 - 56,973,927UniSTS
RGSC_v3.11157,031,332 - 57,031,516RGD
RH 2.0 Map11223.6RGD
Cytogenetic Map11q21-q22UniSTS
Flank 2: (D11Mgh6)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21118,976,208 - 18,976,310 (+)MAPPER
Rnor_6.01119,016,272 - 19,016,371NCBI
Rnor_5.01122,660,494 - 22,660,593UniSTS
RGSC_v3.41119,445,919 - 19,446,020RGD
RGSC_v3.41119,445,921 - 19,446,020UniSTS
RGSC_v3.11119,445,919 - 19,446,020RGD
Celera1118,900,385 - 18,900,484UniSTS
RH 3.4 Map1170.7UniSTS
RH 3.4 Map1170.7RGD
RH 2.0 Map11359.6RGD
Cytogenetic Map11 RGD


1 to 10 of 38 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111897620824697116Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat

1 to 10 of 38 rows


Database
Acc Id
Source(s)
NCBI Gene Iddm17

Note Type Note Reference
qtl_cross_type backcross  
qtl_disease responsible for the development of moderate to severe insulitis and onset of diabetes 634732
qtl_general also verified by the (LETO x KDP)F1 x KDP backcross 634732
qtl_map homologs located in human chr 3p11-q13 and between Gap43 and D16Mit46 on mouse chr 16 634732