Kcnj6 (potassium inwardly-rectifying channel, subfamily J, member 6) - Rat Genome Database
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Gene: Kcnj6 (potassium inwardly-rectifying channel, subfamily J, member 6) Rattus norvegicus
Analyze
Symbol: Kcnj6
Name: potassium inwardly-rectifying channel, subfamily J, member 6
RGD ID: 2959
Description: Exhibits G-protein alpha-subunit binding activity. Involved in cellular response to morphine and response to electrical stimulus. Localizes to several cellular components, including cell surface; dendrite; and neuronal cell body membrane. Human ortholog(s) of this gene implicated in alcohol use disorder and heroin dependence. Orthologous to human KCNJ6 (potassium inwardly rectifying channel subfamily J member 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: BIR1; G protein-activated inward rectifier potassium channel 2; GIRK-2; GIRK2; inward rectifier K(+) channel Kir3.2; KATP-2; LOC360252; potassium channel, inwardly rectifying subfamily J member 6; potassium channel, inwardly rectifying subfamily J, member 6; Potassium inwardly-rectifying channel subfamily J member 6; potassium voltage-gated channel subfamily J member 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21134,061,705 - 34,309,128 (-)NCBI
Rnor_6.0 Ensembl1135,024,196 - 35,099,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01135,011,007 - 35,262,362 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01138,602,645 - 38,692,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,025,118 - 35,116,500 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11135,096,649 - 35,172,743NCBI
Celera1134,144,832 - 34,389,786 (+)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:7926018   PMID:11883954   PMID:16780588   PMID:16797547   PMID:17296805   PMID:18698588   PMID:19118199   PMID:19558451   PMID:21653876   PMID:22098295   PMID:26199148   PMID:26460748  
PMID:28291959   PMID:28951616   PMID:31386893  


Genomics

Comparative Map Data
Kcnj6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21134,061,705 - 34,309,128 (-)NCBI
Rnor_6.0 Ensembl1135,024,196 - 35,099,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01135,011,007 - 35,262,362 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01138,602,645 - 38,692,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,025,118 - 35,116,500 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11135,096,649 - 35,172,743NCBI
Celera1134,144,832 - 34,389,786 (+)NCBICelera
Cytogenetic Map11q11NCBI
KCNJ6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2137,607,373 - 38,121,345 (-)EnsemblGRCh38hg38GRCh38
GRCh382137,607,373 - 37,916,457 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372138,979,675 - 39,288,760 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362137,918,655 - 38,210,566 (-)NCBINCBI36hg18NCBI36
Build 342137,918,656 - 38,210,566NCBI
Celera2124,194,896 - 24,487,265 (-)NCBI
Cytogenetic Map21q22.13NCBI
HuRef2124,470,127 - 24,761,921 (-)NCBIHuRef
CHM1_12138,557,669 - 38,850,112 (-)NCBICHM1_1
Kcnj6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391694,545,839 - 94,798,719 (-)NCBIGRCm39mm39
GRCm39 Ensembl1694,549,495 - 94,798,560 (-)Ensembl
GRCm381694,744,980 - 94,997,696 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1694,748,636 - 94,997,701 (-)EnsemblGRCm38mm10GRCm38
MGSCv371694,970,290 - 95,219,303 (-)NCBIGRCm37mm9NCBIm37
MGSCv361694,857,497 - 95,106,494 (-)NCBImm8
Celera1695,836,339 - 96,085,607 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1655.44NCBI
Kcnj6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540736,659,627 - 36,924,024 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540736,670,824 - 36,923,960 (-)NCBIChiLan1.0ChiLan1.0
KCNJ6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12137,339,201 - 37,634,876 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2137,340,738 - 37,558,688 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02123,983,485 - 24,284,759 (-)NCBIMhudiblu_PPA_v0panPan3
KCNJ6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3132,755,899 - 32,934,478 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13132,752,585 - 33,010,999 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Kcnj6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365005,002,668 - 5,164,511 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13201,243,609 - 201,525,630 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113201,231,803 - 201,525,943 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213211,406,250 - 211,613,586 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1281,569,659 - 81,878,047 (-)NCBI
Kcnj6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474525,879,671 - 26,130,998 (+)NCBI

Position Markers
D11Rat97  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01135,056,301 - 35,056,428NCBIRnor6.0
Rnor_5.01138,650,211 - 38,650,338UniSTSRnor5.0
RGSC_v3.41135,072,772 - 35,072,900RGDRGSC3.4
RGSC_v3.41135,072,773 - 35,072,900UniSTSRGSC3.4
RGSC_v3.11135,128,969 - 35,129,320RGD
Celera1134,344,651 - 34,344,778UniSTS
SHRSP x BN Map1110.4299UniSTS
SHRSP x BN Map1110.4299RGD
Cytogenetic Map11q11UniSTS
D14Rat111  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0142,564,744 - 2,564,958NCBIRnor6.0
Rnor_5.0142,563,788 - 2,564,002UniSTSRnor5.0
Rnor_5.01138,631,875 - 38,632,089UniSTSRnor5.0
RGSC_v3.4142,107,017 - 2,107,231UniSTSRGSC3.4
RGSC_v3.4142,107,016 - 2,107,231RGDRGSC3.4
RGSC_v3.41135,054,437 - 35,054,651UniSTSRGSC3.4
RGSC_v3.41135,054,436 - 35,054,651RGDRGSC3.4
RGSC_v3.1142,107,017 - 2,107,231RGD
Celera141,580,055 - 1,580,269UniSTS
RH 3.4 Map1426.6RGD
RH 3.4 Map1426.6UniSTS
RH 2.0 Map1419.9RGD
SHRSP x BN Map140.0RGD
Cytogenetic Map11q11UniSTS
Cytogenetic Map14p22UniSTS
D11Mco6  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01135,177,895 - 35,178,247NCBIRnor6.0
Rnor_5.01138,769,861 - 38,770,213UniSTSRnor5.0
RGSC_v3.41135,208,370 - 35,208,723RGDRGSC3.4
RGSC_v3.41135,208,371 - 35,208,723UniSTSRGSC3.4
RGSC_v3.11135,264,613 - 35,264,966RGD
Celera1134,223,332 - 34,223,684UniSTS
Cytogenetic Map11q11UniSTS
UniSTS:143667  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01135,098,241 - 35,098,504NCBIRnor6.0
Rnor_5.01138,692,371 - 38,692,634UniSTSRnor5.0
RGSC_v3.41135,115,900 - 35,116,163UniSTSRGSC3.4
Celera1134,302,962 - 34,303,225UniSTS
Cytogenetic Map11q11UniSTS
RH132210  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01135,011,066 - 35,011,251NCBIRnor6.0
Rnor_5.01138,602,696 - 38,602,881UniSTSRnor5.0
RGSC_v3.41135,025,169 - 35,025,354UniSTSRGSC3.4
Celera1134,389,550 - 34,389,735UniSTS
Cytogenetic Map11q11UniSTS
RH94617  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01135,025,402 - 35,025,544NCBIRnor6.0
Rnor_5.01138,617,984 - 38,618,126UniSTSRnor5.0
RGSC_v3.41135,040,457 - 35,040,599UniSTSRGSC3.4
Celera1134,375,363 - 34,375,505UniSTS
Cytogenetic Map11q11UniSTS
AI412840  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01135,024,378 - 35,024,536NCBIRnor6.0
Rnor_5.01138,616,960 - 38,617,118UniSTSRnor5.0
RGSC_v3.41135,039,433 - 35,039,591UniSTSRGSC3.4
Celera1134,376,371 - 34,376,529UniSTS
RH 3.4 Map11254.81UniSTS
Cytogenetic Map11q11UniSTS
UniSTS:259101  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01135,098,305 - 35,098,558NCBIRnor6.0
Rnor_5.01138,692,435 - 38,692,688UniSTSRnor5.0
RGSC_v3.41135,115,964 - 35,116,217UniSTSRGSC3.4
Celera1134,302,908 - 34,303,161UniSTS
Cytogenetic Map11q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11172720192Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)1132503169342559Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11935127454351274Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)111136730644444347Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111632197346583360Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111947517979734728Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)112194422966944229Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)112194422966944229Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)112204314944444112Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112540112970401129Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112572003870720038Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112572003870720038Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112572003870720038Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112572003870720038Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112831466586994795Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113043533963186373Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)113043533986714631Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113215552082443118Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:70
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000066940
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 38
Low 26
Below cutoff 14 8 1 10 1 8 9 8 15 11 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000066940   ⟹   ENSRNOP00000059308
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1135,025,988 - 35,099,383 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079955   ⟹   ENSRNOP00000069879
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1135,024,196 - 35,098,883 (-)Ensembl
RefSeq Acc Id: NM_013192   ⟹   NP_037324
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21134,061,710 - 34,308,758 (-)NCBI
Rnor_6.01135,011,015 - 35,262,362 (-)NCBI
Rnor_5.01138,602,645 - 38,692,971 (-)NCBI
RGSC_v3.41135,025,118 - 35,116,500 (-)RGD
Celera1134,144,832 - 34,389,786 (+)RGD
Sequence:
RefSeq Acc Id: XM_008768567   ⟹   XP_008766789
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01135,024,326 - 35,098,870 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597888   ⟹   XP_017453377
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01135,011,007 - 35,098,851 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088045   ⟹   XP_038943973
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21134,061,705 - 34,309,128 (-)NCBI
RefSeq Acc Id: XM_039088046   ⟹   XP_038943974
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21134,061,705 - 34,309,128 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_037324   ⟸   NM_013192
- UniProtKB: P48550 (UniProtKB/Swiss-Prot),   Q54A91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766789   ⟸   XM_008768567
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017453377   ⟸   XM_017597888
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000069879   ⟸   ENSRNOT00000079955
RefSeq Acc Id: ENSRNOP00000059308   ⟸   ENSRNOT00000066940
RefSeq Acc Id: XP_038943974   ⟸   XM_039088046
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038943973   ⟸   XM_039088045
- Peptide Label: isoform X1
Protein Domains
IRK   IRK_C

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2959 AgrOrtholog
Ensembl Genes ENSRNOG00000001658 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000059308 UniProtKB/TrEMBL
  ENSRNOP00000069879 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066940 UniProtKB/TrEMBL
  ENSRNOT00000079955 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.1400 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir3.2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kir_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25743 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25743 ENTREZGENE
PANTHER PTHR11767 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11767:SF19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IRK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KCNJ6 RGD
PhenoGen Kcnj6 PhenoGen
PIRSF GIRK_kir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS KIR32CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIRCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC234590
UniProt A0A0G2JWH0_RAT UniProtKB/TrEMBL
  F1LS53_RAT UniProtKB/TrEMBL
  KCNJ6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q54A91 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-19 Kcnj6  potassium inwardly-rectifying channel, subfamily J, member 6  Kcnj6  potassium voltage-gated channel subfamily J member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Kcnj6  potassium voltage-gated channel subfamily J member 6  Kcnj6  potassium channel, inwardly rectifying subfamily J, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnj6  potassium channel, inwardly rectifying subfamily J, member 6  Kcnj6  potassium inwardly-rectifying channel, subfamily J, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-23 Kcnj6  potassium inwardly-rectifying channel, subfamily J, member 6  Kcnj6_predicted  potassium inwardly-rectifying channel, subfamily J, member 6 (predicted)  Data Merged 737654 APPROVED
2005-01-12 Kcnj6_predicted  potassium inwardly-rectifying channel, subfamily J, member 6 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Kcnj6  Potassium inwardly-rectifying, channel, subfamily J, member 6      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain and insulinoma cells 728997