Map6d1 (MAP6 domain containing 1) - Rat Genome Database

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Gene: Map6d1 (MAP6 domain containing 1) Rattus norvegicus
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Symbol: Map6d1
Name: MAP6 domain containing 1
RGD ID: 1560102
Description: Predicted to enable calmodulin binding activity and microtubule binding activity. Predicted to be involved in cytoskeleton-dependent intracellular transport and regulation of microtubule cytoskeleton organization. Predicted to act upstream of or within N-terminal peptidyl-L-cysteine N-palmitoylation and negative regulation of microtubule depolymerization. Predicted to be active in Golgi-associated vesicle; cis-Golgi network; and microtubule. Orthologous to human MAP6D1 (MAP6 domain containing 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC363823; MAP6 domain-containing protein 1; RGD1560102; similar to hypothetical protein FLJ12748
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81194,238,552 - 94,244,781 (+)NCBIGRCr8
mRatBN7.21180,734,148 - 80,740,377 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,734,148 - 80,740,377 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,453,328 - 89,459,677 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01182,106,664 - 82,113,013 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01181,167,807 - 81,174,156 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,321,078 - 84,327,307 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,321,078 - 84,327,307 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,385,908 - 87,392,137 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,981,697 - 82,987,926 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1179,569,527 - 79,575,756 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16837464   PMID:22871113  


Genomics

Comparative Map Data
Map6d1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81194,238,552 - 94,244,781 (+)NCBIGRCr8
mRatBN7.21180,734,148 - 80,740,377 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,734,148 - 80,740,377 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,453,328 - 89,459,677 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01182,106,664 - 82,113,013 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01181,167,807 - 81,174,156 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,321,078 - 84,327,307 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,321,078 - 84,327,307 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,385,908 - 87,392,137 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,981,697 - 82,987,926 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1179,569,527 - 79,575,756 (+)NCBICelera
Cytogenetic Map11q23NCBI
MAP6D1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383183,815,922 - 183,825,577 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3183,815,922 - 183,825,594 (-)EnsemblGRCh38hg38GRCh38
GRCh373183,533,710 - 183,543,365 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,016,364 - 185,026,059 (-)NCBINCBI36Build 36hg18NCBI36
Celera3181,977,044 - 181,986,772 (-)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3180,943,007 - 180,952,730 (-)NCBIHuRef
CHM1_13183,498,018 - 183,507,719 (-)NCBICHM1_1
T2T-CHM13v2.03186,625,430 - 186,635,070 (-)NCBIT2T-CHM13v2.0
Map6d1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,052,059 - 20,060,108 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,052,053 - 20,060,108 (-)EnsemblGRCm39 Ensembl
GRCm381620,233,309 - 20,241,358 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,233,303 - 20,241,358 (-)EnsemblGRCm38mm10GRCm38
MGSCv371620,233,382 - 20,241,431 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361620,148,791 - 20,154,863 (-)NCBIMGSCv36mm8
Celera1620,797,081 - 20,805,013 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.39NCBI
MAP6D1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22181,687,890 - 181,697,608 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13181,692,606 - 181,702,324 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03180,851,848 - 180,861,561 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13189,019,315 - 189,028,588 (-)NCBIpanpan1.1PanPan1.1panPan2
MAP6D1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13416,781,131 - 16,788,432 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3420,873,522 - 20,873,923 (-)NCBIDog10K_Boxer_Tasha
Dog10K_Boxer_Tasha3420,868,517 - 20,873,468 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03416,693,414 - 16,693,823 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.03416,688,409 - 16,693,360 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13416,726,662 - 16,731,612 (-)NCBIUMICH_Zoey_3.1
UMICH_Zoey_3.13416,731,666 - 16,732,072 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03416,722,324 - 16,727,271 (-)NCBIUNSW_CanFamBas_1.0
UNSW_CanFamBas_1.03416,727,325 - 16,727,734 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03416,956,945 - 16,957,354 (-)NCBIUU_Cfam_GSD_1.0
UU_Cfam_GSD_1.03416,951,941 - 16,956,891 (-)NCBIUU_Cfam_GSD_1.0
Map6d1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,903,807 - 119,911,309 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365785,995,529 - 6,000,692 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365785,995,629 - 6,003,148 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP6D1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13121,748,648 - 121,755,445 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113121,738,392 - 121,755,482 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,181,186 - 131,190,522 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP6D1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,593,259 - 5,603,781 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,593,327 - 5,601,936 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606314,375,675 - 14,385,812 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map6d1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473072,685,794 - 72,690,561 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473072,683,993 - 72,692,105 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map6d1
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:67
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000058043
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
RH143813  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,734,623 - 80,734,798 (+)MAPPERmRatBN7.2
Rnor_6.01184,321,554 - 84,321,728NCBIRnor6.0
Rnor_5.01187,386,384 - 87,386,558UniSTSRnor5.0
RGSC_v3.41182,982,173 - 82,982,347UniSTSRGSC3.4
Celera1179,570,003 - 79,570,177UniSTS
RH 3.4 Map11668.8UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 11 49 113 69 68 37 25 37 6 187 97 93 39 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000058043   ⟹   ENSRNOP00000054851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,734,148 - 80,740,377 (+)Ensembl
Rnor_6.0 Ensembl1184,321,078 - 84,327,307 (+)Ensembl
RefSeq Acc Id: NM_001108844   ⟹   NP_001102314
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,238,552 - 94,244,781 (+)NCBI
mRatBN7.21180,734,148 - 80,740,377 (+)NCBI
Rnor_6.01184,321,078 - 84,327,307 (+)NCBI
Rnor_5.01187,385,908 - 87,392,137 (+)NCBI
RGSC_v3.41182,981,697 - 82,987,926 (+)RGD
Celera1179,569,527 - 79,575,756 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102314 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77988 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054851.2
RefSeq Acc Id: NP_001102314   ⟸   NM_001108844
- UniProtKB: D3ZT16 (UniProtKB/TrEMBL),   A6JSB9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054851   ⟸   ENSRNOT00000058043

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZT16-F1-model_v2 AlphaFold D3ZT16 1-191 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698282
Promoter ID:EPDNEW_R8807
Type:single initiation site
Name:Map6d1_1
Description:MAP6 domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01184,321,115 - 84,321,175EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560102 AgrOrtholog
BioCyc Gene G2FUF-20713 BioCyc
Ensembl Genes ENSRNOG00000001911 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058043.3 UniProtKB/TrEMBL
InterPro STOP UniProtKB/TrEMBL
KEGG Report rno:363823 UniProtKB/TrEMBL
NCBI Gene 363823 ENTREZGENE
PANTHER MAP6 DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  STOP UniProtKB/TrEMBL
Pfam MAP6 UniProtKB/TrEMBL
PhenoGen Map6d1 PhenoGen
RatGTEx ENSRNOG00000001911 RatGTEx
UniProt A6JSB9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZT16 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-28 Map6d1  MAP6 domain containing 1  RGD1560102_predicted  similar to hypothetical protein FLJ12748 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560102_predicted  similar to hypothetical protein FLJ12748 (predicted)  LOC363823  similar to hypothetical protein FLJ12748  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363823  similar to hypothetical protein FLJ12748      Symbol and Name status set to provisional 70820 PROVISIONAL