Lztr1 (leucine-zipper-like transcription regulator 1) - Rat Genome Database

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Gene: Lztr1 (leucine-zipper-like transcription regulator 1) Rattus norvegicus
Analyze
Symbol: Lztr1
Name: leucine-zipper-like transcription regulator 1
RGD ID: 1309100
Description: Predicted to enable small GTPase binding activity. Predicted to be involved in negative regulation of Ras protein signal transduction and protein ubiquitination. Predicted to be located in recycling endosome membrane. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); glioblastoma; hepatocellular carcinoma; hypertrophic cardiomyopathy; and neurilemmoma (multiple). Orthologous to human LZTR1 (leucine zipper like transcription regulator 1); INTERACTS WITH endosulfan; paracetamol; vinclozolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: leucine-zipper-like transcriptional regulator 1; leucine-zipper-like transcriptional regulator, 1; LOC360745
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21183,487,717 - 83,503,896 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1183,487,717 - 83,503,633 (-)Ensembl
Rnor_6.01187,381,638 - 87,397,849 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,381,899 - 87,397,498 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,432,972 - 90,449,143 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,479,494 - 85,495,053 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11185,520,301 - 85,542,781 (-)NCBI
Celera1182,256,659 - 82,272,218 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A novel pretherapeutic gene expression-based risk score for treatment guidance in gastric cancer. Bauer L, etal., Ann Oncol. 2018 Jan 1;29(1):127-132. doi: 10.1093/annonc/mdx685.
2. A mosaic pattern of INI1/SMARCB1 protein expression distinguishes Schwannomatosis and NF2-associated peripheral schwannomas from solitary peripheral schwannomas and NF2-associated vestibular schwannomas. Caltabiano R, etal., Childs Nerv Syst. 2017 Jun;33(6):933-940. doi: 10.1007/s00381-017-3340-2. Epub 2017 Apr 1.
3. Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma. Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu and Cancer Genome Atlas Research Network, Cell. 2017 Jun 15;169(7):1327-1341.e23. doi: 10.1016/j.cell.2017.05.046.
4. RIT1 oncoproteins escape LZTR1-mediated proteolysis. Castel P, etal., Science. 2019 Mar 15;363(6432):1226-1230. doi: 10.1126/science.aav1444.
5. Providing more evidence on LZTR1 variants in Noonan syndrome patients. Chinton J, etal., Am J Med Genet A. 2020 Feb;182(2):409-414. doi: 10.1002/ajmg.a.61445. Epub 2019 Dec 11.
6. The integrated landscape of driver genomic alterations in glioblastoma. Frattini V, etal., Nat Genet. 2013 Oct;45(10):1141-9. doi: 10.1038/ng.2734. Epub 2013 Aug 5.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. LZTR1-Related Hypertrophic Cardiomyopathy Without Typical Noonan Syndrome Features. Jenkins J, etal., Circ Genom Precis Med. 2020 Apr;13(2):e002690. doi: 10.1161/CIRCGEN.119.002690. Epub 2020 Jan 31.
10. Targeted next-generation sequencing for differential diagnosis of neurofibromatosis type 2, schwannomatosis, and meningiomatosis. Louvrier C, etal., Neuro Oncol. 2018 Jun 18;20(7):917-929. doi: 10.1093/neuonc/noy009.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas. Piotrowski A, etal., Nat Genet. 2014 Feb;46(2):182-7. doi: 10.1038/ng.2855. Epub 2013 Dec 22.
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. The Noonan Syndrome Gene Lztr1 Controls Cardiovascular Function by Regulating Vesicular Trafficking. Sewduth RN, etal., Circ Res. 2020 May 8;126(10):1379-1393. doi: 10.1161/CIRCRESAHA.119.315730. Epub 2020 Mar 16.
17. Mutations in LZTR1 add to the complex heterogeneity of schwannomatosis. Smith MJ, etal., Neurology. 2015 Jan 13;84(2):141-7. doi: 10.1212/WNL.0000000000001129. Epub 2014 Dec 5.
Additional References at PubMed
PMID:12477932   PMID:16356934   PMID:30442762   PMID:30442766   PMID:31904090  


Genomics

Comparative Map Data
Lztr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21183,487,717 - 83,503,896 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1183,487,717 - 83,503,633 (-)Ensembl
Rnor_6.01187,381,638 - 87,397,849 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,381,899 - 87,397,498 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,432,972 - 90,449,143 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,479,494 - 85,495,053 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11185,520,301 - 85,542,781 (-)NCBI
Celera1182,256,659 - 82,272,218 (-)NCBICelera
Cytogenetic Map11q23NCBI
LZTR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,982,297 - 20,999,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2220,982,269 - 20,999,032 (+)EnsemblGRCh38hg38GRCh38
GRCh372221,336,586 - 21,353,321 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,666,558 - 19,683,326 (+)NCBINCBI36hg18NCBI36
Build 342219,661,209 - 19,677,879NCBI
Celera224,827,905 - 4,844,645 (+)NCBI
Cytogenetic Map22q11.21NCBI
HuRef224,604,854 - 4,621,598 (+)NCBIHuRef
CHM1_12221,336,755 - 21,353,527 (+)NCBICHM1_1
T2T-CHM13v2.02221,391,107 - 21,407,823 (+)NCBI
Lztr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,326,124 - 17,344,197 (+)NCBIGRCm39mm39
GRCm39 Ensembl1617,326,552 - 17,344,197 (+)Ensembl
GRCm381617,508,260 - 17,526,333 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,508,688 - 17,526,333 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,509,064 - 17,526,423 (+)NCBIGRCm37mm9NCBIm37
MGSCv361617,422,534 - 17,439,893 (+)NCBImm8
Celera1618,082,040 - 18,099,435 (+)NCBICelera
Cytogenetic Map16A3NCBI
Lztr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,315,427 - 19,333,522 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544219,315,427 - 19,333,361 (-)NCBIChiLan1.0ChiLan1.0
LZTR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12219,695,348 - 19,713,007 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2219,695,228 - 19,713,007 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0223,206,019 - 3,223,050 (+)NCBIMhudiblu_PPA_v0panPan3
LZTR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,501,793 - 30,519,698 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,503,071 - 30,519,611 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,460,228 - 30,477,473 (-)NCBI
ROS_Cfam_1.02631,910,805 - 31,928,017 (-)NCBI
ROS_Cfam_1.0 Ensembl2631,910,811 - 31,943,250 (-)Ensembl
UMICH_Zoey_3.12629,956,683 - 29,973,831 (-)NCBI
UNSW_CanFamBas_1.02629,580,661 - 29,597,796 (-)NCBI
UU_Cfam_GSD_1.02630,669,630 - 30,686,843 (-)NCBI
Lztr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,230,562 - 140,248,621 (-)NCBI
SpeTri2.0NW_0049366192,505,300 - 2,523,500 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LZTR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,569,746 - 50,589,787 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,576,413 - 50,590,397 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,025,428 - 54,038,534 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LZTR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,917,381 - 4,935,174 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl194,918,360 - 4,933,439 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660852,034,445 - 2,052,891 (-)NCBIVero_WHO_p1.0
Lztr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624945691,059 - 709,564 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624945691,063 - 709,599 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:91
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000002554
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002554   ⟹   ENSRNOP00000002554
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,487,717 - 83,503,633 (-)Ensembl
Rnor_6.0 Ensembl1187,381,899 - 87,397,498 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101549   ⟹   ENSRNOP00000082766
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,487,717 - 83,503,633 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109441   ⟹   ENSRNOP00000076809
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1183,487,717 - 83,503,633 (-)Ensembl
RefSeq Acc Id: NM_001108326   ⟹   NP_001101796
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,488,053 - 83,503,612 (-)NCBI
Rnor_6.01187,381,954 - 87,397,513 (+)NCBI
Rnor_5.01190,432,972 - 90,449,143 (+)NCBI
RGSC_v3.41185,479,494 - 85,495,053 (-)RGD
Celera1182,256,659 - 82,272,218 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248707   ⟹   XP_006248769
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,487,717 - 83,503,896 (-)NCBI
Rnor_6.01187,381,638 - 87,397,849 (+)NCBI
Rnor_5.01190,432,972 - 90,449,143 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088534   ⟹   XP_038944462
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,487,717 - 83,502,978 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101796 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248769 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944462 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI69071 (Get FASTA)   NCBI Sequence Viewer  
  EDL77892 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001101796   ⟸   NM_001108326
- UniProtKB: B5DFI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248769   ⟸   XM_006248707
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000002554   ⟸   ENSRNOT00000002554
RefSeq Acc Id: XP_038944462   ⟸   XM_039088534
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000076809   ⟸   ENSRNOT00000109441
RefSeq Acc Id: ENSRNOP00000082766   ⟸   ENSRNOT00000101549
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DFI4-F1-model_v2 AlphaFold B5DFI4 1-837 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698319
Promoter ID:EPDNEW_R8843
Type:initiation region
Name:Lztr1_1
Description:leucine-zipper-like transcription regulator 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01187,381,929 - 87,381,989EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309100 AgrOrtholog
BioCyc Gene G2FUF-20591 BioCyc
Ensembl Genes ENSRNOG00000001870 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002554 ENTREZGENE
  ENSRNOP00000002554.5 UniProtKB/TrEMBL
  ENSRNOP00000076809.1 UniProtKB/TrEMBL
  ENSRNOP00000082766.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002554 ENTREZGENE
  ENSRNOT00000002554.7 UniProtKB/TrEMBL
  ENSRNOT00000101549.1 UniProtKB/TrEMBL
  ENSRNOT00000109441.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.80 UniProtKB/TrEMBL
  3.30.710.10 UniProtKB/TrEMBL
InterPro BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  Gal_Oxase/kelch_b-propeller UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
KEGG Report rno:360745 UniProtKB/TrEMBL
NCBI Gene 360745 ENTREZGENE
Pfam BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PhenoGen Lztr1 PhenoGen
PROSITE BTB UniProtKB/TrEMBL
SMART BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF117281 UniProtKB/TrEMBL
  SSF50965 UniProtKB/TrEMBL
UniProt A0A8I5Y0T3_RAT UniProtKB/TrEMBL
  A0A8I5ZVJ5_RAT UniProtKB/TrEMBL
  B5DFI4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Lztr1  leucine-zipper-like transcription regulator 1  Lztr1  leucine-zipper-like transcriptional regulator, 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Lztr1  leucine-zipper-like transcriptional regulator, 1   Lztr1_predicted  leucine-zipper-like transcriptional regulator, 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lztr1_predicted  leucine-zipper-like transcriptional regulator, 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED