Fstl1 (follistatin-like 1) - Rat Genome Database

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Gene: Fstl1 (follistatin-like 1) Rattus norvegicus
Analyze
Symbol: Fstl1
Name: follistatin-like 1
RGD ID: 68955
Description: Predicted to enable calcium ion binding activity and heparin binding activity. Predicted to be involved in several processes, including endothelial cell differentiation; endothelial cell migration; and regulation of BMP signaling pathway. Predicted to act upstream of or within hematopoietic stem cell homeostasis. Predicted to be active in extracellular region. Orthologous to human FSTL1 (follistatin like 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: follistatin-like; follistatin-like protein 1; follistatin-related protein; follistatin-related protein 1; follistatin-related protein precursor; Frp; Fstl; MGC93410
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,400,870 - 76,454,053 (-)NCBIGRCr8
mRatBN7.21162,895,391 - 62,948,581 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,779,783 - 62,948,677 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,707,886 - 71,761,075 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01164,370,096 - 64,423,283 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,420,096 - 63,473,181 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,791,196 - 65,845,721 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,782,567 - 65,845,418 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01168,884,410 - 68,938,352 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,681,814 - 64,735,673 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,739,417 - 64,793,262 (-)NCBI
Celera1162,393,441 - 62,446,724 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fstl1RatPrimary Lymphedema with Myelodysplasia  ISOFSTL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Lymphedema more ...ClinVarPMID:19449416 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fstl1Ratacute kidney failure  ISOFSTL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20861081
Fstl1Rataortic valve insufficiency  ISOFSTL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21216836
Fstl1RatExperimental Liver Cirrhosis  ISOFSTL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Fstl1Ratsystemic scleroderma  ISOFSTL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27482699
Fstl1RatWeight Gain  ISOFSTL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19030233
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fstl1Ratpulmonary emphysema  ISSFstl1 (Mus musculus)13592920OMIM:130700MouseDO 

1 to 20 of 155 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fstl1Rat(1->4)-beta-D-glucan multiple interactionsISOFstl1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of FSTL1 mRNACTDPMID:36331819
Fstl1Rat1,2-dimethylhydrazine increases expressionISOFstl1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of FSTL1 mRNACTDPMID:22206623
Fstl1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of FSTL1 mRNACTDPMID:25380136
Fstl1Rat17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of FSTL1 mRNACTDPMID:16079270
Fstl1Rat17beta-estradiol multiple interactionsISOFSTL1 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of FSTL1 mRNACTDPMID:30165855
Fstl1Rat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISOFstl1 (Mus musculus)6480464[Flame Retardants results in increased abundance of 2 more ...CTDPMID:38995820
Fstl1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of FSTL1 mRNACTDPMID:34747641
Fstl1Rat2,4,6-trinitrobenzenesulfonic acid multiple interactionsISOFstl1 (Mus musculus)6480464Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FSTL1 mRNA]CTDPMID:18200517
Fstl1Rat2,4,6-trinitrobenzenesulfonic acid increases expressionISOFstl1 (Mus musculus)6480464Trinitrobenzenesulfonic Acid results in increased expression of FSTL1 mRNACTDPMID:18200517
Fstl1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOFstl1 (Mus musculus)64804642 more ...CTDPMID:38648751
Fstl1Rat2-butoxyethanol increases expressionISOFstl1 (Mus musculus)6480464n-butoxyethanol results in increased expression of FSTL1 mRNACTDPMID:19812364
Fstl1Rat3,4-dichloroaniline decreases expressionISOFSTL1 (Homo sapiens)64804643 and 4-dichloroaniline results in decreased expression of FSTL1 mRNACTDPMID:24172598
Fstl1Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOFSTL1 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of FSTL1 mRNACTDPMID:28628672
Fstl1Rat3-methylcholanthrene decreases expressionISOFstl1 (Mus musculus)6480464Methylcholanthrene results in decreased expression of FSTL1 mRNACTDPMID:20713471
Fstl1Rat4,4'-diaminodiphenylmethane increases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in increased expression of FSTL1 mRNACTDPMID:25380136
Fstl1Rat4,4'-sulfonyldiphenol increases expressionISOFstl1 (Mus musculus)6480464bisphenol S results in increased expression of FSTL1 mRNACTDPMID:30951980 and PMID:39298647
Fstl1Rat4,4'-sulfonyldiphenol increases expressionISOFSTL1 (Homo sapiens)6480464bisphenol S results in increased expression of FSTL1 proteinCTDPMID:34186270
Fstl1Rat4,4'-sulfonyldiphenol decreases methylationISOFSTL1 (Homo sapiens)6480464bisphenol S results in decreased methylation of FSTL1 geneCTDPMID:31601247
Fstl1Rat4-hydroxyphenyl retinamide decreases expressionISOFstl1 (Mus musculus)6480464Fenretinide results in decreased expression of FSTL1 mRNACTDPMID:28973697
Fstl1Rat5-aza-2'-deoxycytidine increases expressionISOFSTL1 (Homo sapiens)6480464Decitabine results in increased expression of FSTL1 mRNACTDPMID:19194470

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Biological Process
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Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fstl1Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Fstl1Ratextracellular region is_active_inIBAFB:FBgn0259878 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Fstl1Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fstl1Ratcalcium ion binding enablesIEAInterPro:IPR0020481600115GO_REF:0000002InterProGO_REF:0000002
Fstl1Ratheparin binding enablesIEAUniProtKB-KW:KW-03581600115GO_REF:0000043UniProtGO_REF:0000043
Fstl1Ratprotein binding enablesISOFstl1 (Mus musculus)1624291UniProtKB:Q14689 and PMID:20054002RGDPMID:20054002
Fstl1Ratprotein binding enablesISOFSTL1 (Homo sapiens)1624291UniProtKB:A4D1W7 more ...RGDPMID:19060904 more ...


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Reference Title
Reference Citation
1. Characterization of rat follistatin-related gene: effects of estrous cycle stage and pregnancy on its messenger RNA expression in rat reproductive tissues. Arai KY, etal., Biol Reprod 2003 Jan;68(1):199-206.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Remmers EF, etal., Transplant Proc 1999 May;31(3):1549-54.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Regulation of FLRG expression in rat primary astroglial cells and injured brain tissue by transforming growth factor-beta 1 (TGF-beta 1). Zhang G, etal., J Neurosci Res 2003 Apr 1;72(1):33-45.
11. Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue. Zwijsen A, etal., Eur J Biochem 1994 Nov 1;225(3):937-46.
1 to 11 of 11 rows
PMID:12477932   PMID:12591166   PMID:15489334   PMID:16502470   PMID:18925901   PMID:20054002   PMID:23533145   PMID:24006456   PMID:25139876   PMID:26687945   PMID:27561749   PMID:28188034  
PMID:31139662   PMID:35585770   PMID:35766911   PMID:38436106  



Fstl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,400,870 - 76,454,053 (-)NCBIGRCr8
mRatBN7.21162,895,391 - 62,948,581 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,779,783 - 62,948,677 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,707,886 - 71,761,075 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01164,370,096 - 64,423,283 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,420,096 - 63,473,181 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,791,196 - 65,845,721 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,782,567 - 65,845,418 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01168,884,410 - 68,938,352 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,681,814 - 64,735,673 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,739,417 - 64,793,262 (-)NCBI
Celera1162,393,441 - 62,446,724 (-)NCBICelera
Cytogenetic Map11q21NCBI
FSTL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383120,392,293 - 120,450,992 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3120,392,293 - 120,451,016 (-)EnsemblGRCh38hg38GRCh38
GRCh373120,111,140 - 120,169,839 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363121,595,816 - 121,652,515 (-)NCBINCBI36Build 36hg18NCBI36
Build 343121,595,816 - 121,652,515NCBI
Celera3118,522,464 - 118,579,350 (-)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3117,488,896 - 117,545,793 (-)NCBIHuRef
CHM1_13120,076,707 - 120,133,627 (-)NCBICHM1_1
T2T-CHM13v2.03123,111,839 - 123,170,569 (-)NCBIT2T-CHM13v2.0
Fstl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391637,597,417 - 37,656,878 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1637,597,235 - 37,656,876 (+)EnsemblGRCm39 Ensembl
GRCm381637,777,055 - 37,836,516 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1637,776,873 - 37,836,514 (+)EnsemblGRCm38mm10GRCm38
MGSCv371637,777,141 - 37,836,602 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361637,696,294 - 37,755,755 (+)NCBIMGSCv36mm8
Celera1638,184,966 - 38,244,699 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1626.48NCBI
Fstl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,952,853 - 20,004,241 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542719,952,823 - 20,003,832 (-)NCBIChiLan1.0ChiLan1.0
FSTL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22118,363,612 - 118,419,277 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13118,368,390 - 118,423,861 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03117,508,772 - 117,564,254 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1 Ensembl3124,422,968 - 124,475,431 (-)Ensemblpanpan1.1panPan2
FSTL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,892,317 - 23,914,406 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,894,573 - 23,933,779 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3323,919,531 - 23,972,261 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03324,129,955 - 24,182,735 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3324,129,947 - 24,183,502 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13323,930,929 - 23,983,640 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03323,971,619 - 24,024,230 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03324,535,350 - 24,588,071 (-)NCBIUU_Cfam_GSD_1.0
Fstl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602130,335,041 - 130,388,800 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365367,126,966 - 7,187,269 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365367,132,369 - 7,186,951 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FSTL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13139,847,438 - 139,901,965 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113139,847,246 - 139,901,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FSTL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12260,371,309 - 60,427,259 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2260,371,554 - 60,428,764 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041105,887,988 - 105,942,526 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fstl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473127,790,363 - 27,841,251 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473127,789,671 - 27,839,267 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Fstl1
404 total Variants

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:33
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000003721
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 24 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat

1 to 10 of 24 rows
RH138069  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,909,268 - 62,909,484 (+)MAPPERmRatBN7.2
Rnor_6.01165,806,070 - 65,806,285NCBIRnor6.0
Rnor_5.01168,899,283 - 68,899,498UniSTSRnor5.0
RGSC_v3.41164,696,162 - 64,696,377UniSTSRGSC3.4
Celera1162,407,319 - 62,407,534UniSTS
RH 3.4 Map11492.9UniSTS
Cytogenetic Map11q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000003721   ⟹   ENSRNOP00000003721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,885,835 - 62,917,459 (-)Ensembl
Rnor_6.0 Ensembl1165,782,567 - 65,814,601 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091057   ⟹   ENSRNOP00000072839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,895,378 - 62,948,575 (-)Ensembl
Rnor_6.0 Ensembl1165,792,207 - 65,845,418 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097784   ⟹   ENSRNOP00000077559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,779,783 - 62,948,677 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103472   ⟹   ENSRNOP00000095289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,894,395 - 62,948,354 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110627   ⟹   ENSRNOP00000077415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,779,783 - 62,914,411 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114285   ⟹   ENSRNOP00000080660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,894,395 - 62,948,354 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117870   ⟹   ENSRNOP00000076465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,898,199 - 62,948,354 (-)Ensembl
RefSeq Acc Id: NM_024369   ⟹   NP_077345
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,400,870 - 76,454,053 (-)NCBI
mRatBN7.21162,895,391 - 62,948,581 (-)NCBI
Rnor_6.01165,792,192 - 65,845,375 (-)NCBI
Rnor_5.01168,884,410 - 68,938,352 (-)NCBI
RGSC_v3.41164,681,814 - 64,735,673 (-)RGD
Celera1162,393,441 - 62,446,724 (-)RGD
Sequence:
Protein RefSeqs NP_077345 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA66063 (Get FASTA)   NCBI Sequence Viewer  
  AAH87014 (Get FASTA)   NCBI Sequence Viewer  
  AAP92604 (Get FASTA)   NCBI Sequence Viewer  
  EDM11239 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095289
  ENSRNOP00000095289.1
GenBank Protein Q62632 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077345   ⟸   NM_024369
- Peptide Label: precursor
- UniProtKB: Q62632 (UniProtKB/Swiss-Prot),   A0A8I5Y6A3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072839   ⟸   ENSRNOT00000091057
Ensembl Acc Id: ENSRNOP00000003721   ⟸   ENSRNOT00000003721
Ensembl Acc Id: ENSRNOP00000076465   ⟸   ENSRNOT00000117870
Ensembl Acc Id: ENSRNOP00000077415   ⟸   ENSRNOT00000110627
EF-hand   Follistatin-like   Kazal-like   VWFC

Name Modeler Protein Id AA Range Protein Structure
AF-Q62632-F1-model_v2 AlphaFold Q62632 1-306 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698172
Promoter ID:EPDNEW_R8697
Type:initiation region
Name:Fstl1_1
Description:follistatin-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,845,382 - 65,845,442EPDNEW


1 to 38 of 38 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-21259 BioCyc
Ensembl Genes ENSRNOG00000002746 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000103472 ENTREZGENE
  ENSRNOT00000103472.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7189359 IMAGE-MGC_LOAD
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  Fol_N UniProtKB/Swiss-Prot
  Follistatin/Osteonectin_EGF UniProtKB/Swiss-Prot
  Kazal_dom UniProtKB/Swiss-Prot
  Kazal_dom_sf UniProtKB/Swiss-Prot
  Prot_Inhib_GrowthFact_Antg UniProtKB/Swiss-Prot
KEGG Report rno:79210 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93410 IMAGE-MGC_LOAD
NCBI Gene 79210 ENTREZGENE
PANTHER FOLLISTATIN-RELATED UniProtKB/Swiss-Prot
  FOLLISTATIN-RELATED PROTEIN 1 UniProtKB/Swiss-Prot
Pfam FOLN UniProtKB/Swiss-Prot
  Kazal_2 UniProtKB/Swiss-Prot
PhenoGen Fstl1 PhenoGen
PROSITE EF_HAND_2 UniProtKB/Swiss-Prot
  KAZAL_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002746 RatGTEx
SMART FOLN UniProtKB/Swiss-Prot
  KAZAL UniProtKB/Swiss-Prot
Superfamily-SCOP FnI-like domain UniProtKB/Swiss-Prot
  SSF100895 UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
UniProt A0A8I5XW94_RAT UniProtKB/TrEMBL
  A0A8I5Y6A3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y8X2_RAT UniProtKB/TrEMBL
  A0A8I5ZQA5_RAT UniProtKB/TrEMBL
  A0A8L2R6C3_RAT UniProtKB/TrEMBL
  A6IR86_RAT UniProtKB/TrEMBL
  F8WG88_RAT UniProtKB/TrEMBL
  FSTL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Fstl1  follistatin-like 1  Fstl  follistatin-like  Symbol and Name updated 1299863 APPROVED
2003-04-09 Fstl  follistatin-like  Frp  follistatin-related protein  Symbol and Name updated 629477 APPROVED
2002-06-10 Frp  follistatin-related protein      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_cellular_localization may be secreted from astroglial cells 1299175
gene_expression expressed in the ovary, uterus, testis, lung, adrenal gland, pituitary, kidney, small intestine, placenta and heart 1299174
gene_function heparin-binding protein 1299173
gene_function binds to activins and bone morphogenetic proteins 1299174
gene_process may function as a negative regulator of cell growth 61515
gene_process may play a role in the regulation of reproductive processes 1299174
gene_process regulates activin A in brain wound healing in response to TGF-beta1 1299175
gene_protein native molecular mass of 55-75,000 Da 1299173