Pia27 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Pia27 (Pristane induced arthritis QTL 27) Rattus norvegicus

Symbol: Pia27
Name: Pristane induced arthritis QTL 27
RGD ID: 2302043
Previously known as: Rf1
Trait: blood immunoglobulin amount   (VT:0002460)    
Measurement Type: serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum   (CMO:0002111)    
LOD Score: 18.6
P Value: 0.001
Variance: Not Available
Inheritance Type: dominant
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,566,545 - 83,440,803RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01186,714,475 - 87,444,587RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01189,808,347 - 90,495,881RGDRnor5.0
RGSC_v3.41184,560,085 - 85,432,136RGDRGSC3.4
Cross Type: intercross
Strains Crossed: DA/ZtmRhd E3/ZtmRhd 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition
pristane  (IDA)

Measurement Method

Vertebrate Trait

Rat Strain
DA/ZtmRhd  (IEA)
E3/ZtmRhd  (IEA)

References

References - curated
# Reference Title Reference Citation
1. The genetic control of rheumatoid factor production in a rat model of rheumatoid arthritis. Wernhoff P, etal., Arthritis Rheum. 2003 Dec;48(12):3584-96.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
3703Slc25a1solute carrier family 25 member 1118305576483058781Rat
2379Comtcatechol-O-methyltransferase118256805282587642Rat
61960Txnrd2thioredoxin reductase 2118251999682568156Rat
3243P2rx6purinergic receptor P2X 6118343992283450449Rat
1304951Tssk2testis-specific serine kinase 2118308657883087933Rat
620810Rtn4rreticulon 4 receptor118284430982869251Rat
1306288Klhl22kelch-like family member 22118319089183231746Rat
1306013Scarf2scavenger receptor class F, member 2118317595683187415Rat
1306018Car15carbonic anhydrase 15118314715583150101Rat
1306365Dgcr8DGCR8 microprocessor complex subunit118270467382737251Rat
1307352Tssk1btestis-specific serine kinase 1B118309093083092353Rat
1305333Gsc2goosecoid homeobox 2118307078483075874Rat
1305905Slc7a4solute carrier family 7, member 4118343509383439078Rat
1306655ArvcfARVCF, delta catenin family member118258813782645832Rat
1310521Ranbp1RAN binding protein 1118274260382750836Rat
1310418Trmt2atRNA methyltransferase 2 homolog A118273768982742423Rat
1310567Dgcr2DiGeorge syndrome critical region gene 2118309396183144507Rat
1308218Ess2ess-2 splicing factor homolog118307589383085849Rat
1309390Dgcr6DiGeorge syndrome critical region gene 6118292772582932823Rat
1307560Med15mediator complex subunit 15118328072283356006Rat
1308875Zdhhc8zinc finger DHHC-type palmitoyltransferase 8118275511082769280Rat
1310674Smpd4sphingomyelin phosphodiesterase 4118336253483386257Rat
1310348Tango2transport and golgi organization 2 homolog118264597882692574Rat
1563782Ccdc188coiled-coil domain containing 188118276973582772062Rat
1564601Vpreb1bV-set pre-B cell surrogate light chain 1B118300939683010106Rat
1590932Prodhproline dehydrogenase118291004382927305Rat
1588214Ccdc74acoiled-coil domain containing 74A118335588883360269Rat
2321873Lamtor2-ps2late endosomal/lysosomal adaptor, MAPK and MTOR activator 2, pseudogene 2118340635783406788Rat
2325380Mir185microRNA 185118266471682664795Rat
7489022Mir1306microRNA 1306118270965182709723Rat
7525828LOC102555338uncharacterized LOC102555338118277201982781088Rat
7716638LOC102555762uncharacterized LOC102555762118305318683055591Rat
11457258LOC108352364uncharacterized LOC108352364118341578083421593Rat
41168066LOC120095812U6 spliceosomal RNA118336131483361420Rat
41329290Rps15-ps13ribosomal protein S15, pseudogene 13118328098683288284Rat
41291498Snora77bsmall nucleolar RNA, H/ACA box 77B118274996782750091Rat
41005044Rpl34-ps2ribosomal protein L34, pseudogene 2118330506183314950Rat
41025228LOC120095536protein FAM246A-like118315095283151644Rat
41048783Scarna14l2small Cajal body-specific RNA 14 like 2118261297182613105Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
10375D11Mgh1148118256655382566702Ratregion
10376D11Wox6173118256654582566718Ratregion
11044D11Wox5246118344055583440803Ratregion
37512D11Rat50236118284646682846715Ratregion
38800D11Rat43234118305175483051965Ratregion
39356D11Rat41218118299323282993457Ratregion
1627700D11Got135240118317312483173364Ratregion
1627700D11Got135240118317312483173364Ratregion
7193119Stk22a548118309165283092200Ratregion
7193099AI059538205118344006683440271Ratregion
7206546UniSTS:5470320118305724283058752Ratregion
5035512EST9C6137118275064182750778Ratregion
5035540Dgcr8439118270963882710077Ratregion
5029359RH144497206118268436482684570Ratregion
5035116Stk22b245118308678583087030Ratregion
5032425AI315043150118314955683149706Ratregion
5032425AI315043150118314955683149706Ratregion
5029881BE097295183118335590883356091Ratregion
5033435RH138822121118319142483191545Ratregion
5051901RH94723169118258739382587563Ratregion
5059406AI059538243118343992683440169Ratregion
5059044BE102735203118266236682662570Ratregion
5051202RH134498212118336275183362964Ratregion
5045470RH131196150118306096983061119Ratregion
5046532RH131807183118319102783191210Ratregion
5040022RH128045194118258717982587373Ratregion
5072460RH136862189118273778382737972Ratregion
5076052RH138951155118270422082704375Ratregion
5074488RH138046187118343876783438956Ratregion
5070878RH134757199118336124683361445Ratregion
5073500RH137472202118308454183084743Ratregion
5060424BE110023183118308670783086890Ratregion
5062524BF403357192118274050582740697Ratregion
5062736AW534143154118308648583086639Ratregion
5064338AI763447140118269221682692357Ratregion
5082311BE119158159118268701582687174Ratregion
5087410Stk22a240118309109483091334Ratregion
5083055BF390716153118276904282769195Ratregion
5088064Prodh135118292663682926859Ratregion
5090159AU049586167118272397282724139Ratregion
5503240UniSTS:237454224118273693782737161Ratregion
5503244UniSTS:237455213118275049682750709Ratregion
5503922UniSTS:256469848118307279883073646Ratregion
5504201UniSTS:260493479118309099983091478Ratregion
5504203Es2el0118305651983057529Ratregion
5504207UniSTS:260495143118308683383086976Ratregion
5505826UniSTS:4957971592118307212083073712Ratregion
5505998UniSTS:4967990118307698183077232Ratregion
5506362UniSTS:478969750118307919583079945Ratregion
5500549RH135933204118317597983176183Ratregion
5504199UniSTS:260486102118308655783086659Ratregion
5501675Dgcr60118292792582929587Ratregion
5502465RH1249400118292040082921801Ratregion
Position Markers

Flank 1: (D11Wox6)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,566,545 - 82,566,718 (+)MAPPER
Rnor_6.01186,714,475 - 86,714,647NCBI
Rnor_5.01189,808,347 - 89,808,519UniSTS
RGSC_v3.41184,560,085 - 84,560,257UniSTS
Celera1181,343,615 - 81,343,787UniSTS
Cytogenetic Map11q23UniSTS
Peak: (D11Wox5)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,440,555 - 83,440,803 (-)MAPPER
Rnor_6.01187,444,342 - 87,444,587NCBI
Rnor_5.01190,495,636 - 90,495,881UniSTS
RGSC_v3.41185,431,891 - 85,432,136UniSTS
Celera1182,209,127 - 82,209,372UniSTS
Cytogenetic Map11q23UniSTS
Flank 2: (D11Wox5)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21183,440,555 - 83,440,803 (-)MAPPER
Rnor_6.01187,444,342 - 87,444,587NCBI
Rnor_5.01190,495,636 - 90,495,881UniSTS
RGSC_v3.41185,431,891 - 85,432,136UniSTS
Celera1182,209,127 - 82,209,372UniSTS
Cytogenetic Map11q23UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
2302043Pia27Pristane induced arthritis QTL 2718.60.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)118256654583440803Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercross  
qtl_general this region has no association to rheumatoid arthritis 2302026
qtl_general measurement method: serum samples were collected on days 6, 14, 35, 49, 100, and desired levels were quantified by ELISA 2302026
qtl_general no linkage found for total levels of IgM or IgG 2302026
qtl_general inducing agent and dosage: pristane 150 microliter 2302026
qtl_general software used: Map Manager QTX software and R/qtl in R-Plus package 2302026