Dyrk1a (dual specificity tyrosine phosphorylation regulated kinase 1A) - Rat Genome Database

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Gene: Dyrk1a (dual specificity tyrosine phosphorylation regulated kinase 1A) Rattus norvegicus
Analyze
Symbol: Dyrk1a
Name: dual specificity tyrosine phosphorylation regulated kinase 1A
RGD ID: 2528
Description: Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in protein phosphorylation and regulation of RNA splicing. Located in nuclear speck. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; ageladine A.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual Specificity Yak1-related kinase; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; Dyrk; MNBH; protein kinase minibrain homolog; PSK47; RP86
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21133,890,706 - 34,009,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,890,490 - 34,009,420 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,573,541 - 42,666,554 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01135,244,902 - 35,337,921 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01134,390,728 - 34,483,971 (+)NCBIRnor_WKY
Rnor_6.01134,858,339 - 34,958,733 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1134,865,532 - 34,956,536 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01138,453,019 - 38,550,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,879,733 - 34,970,998 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11134,935,975 - 35,027,241 (+)NCBI
Celera1134,444,072 - 34,535,020 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin filament  (ISO)
axon  (ISO)
cytoplasm  (ISO,ISS)
cytoskeleton  (ISO)
dendrite  (ISO)
microtubule  (ISO)
neurofilament  (ISO)
nuclear speck  (IDA)
nucleolus  (IDA)
nucleus  (IBA,IDA,ISO)
ribonucleoprotein complex  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome. Altafaj X, etal., Neurobiol Dis. 2013 Apr;52:117-27. doi: 10.1016/j.nbd.2012.11.017. Epub 2012 Dec 5.
2. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. Becker W, etal., J Biol Chem. 1998 Oct 2;273(40):25893-902.
3. Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE. Birling MC, etal., Sci Rep. 2017 Mar 7;7:43331. doi: 10.1038/srep43331.
4. Ten new cases further delineate the syndromic intellectual disability phenotype caused by mutations in DYRK1A. Bronicki LM, etal., Eur J Hum Genet. 2015 Nov;23(11):1482-7. doi: 10.1038/ejhg.2015.29. Epub 2015 Apr 29.id: 24774285 Error occurred: The following PMID is not available: 24774285
5. Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate. Chen-Hwang MC, etal., J Biol Chem 2002 May 17;277(20):17597-604.
6. A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro. Coutadeur S, etal., J Neurochem. 2015 May;133(3):440-51. doi: 10.1111/jnc.13018. Epub 2015 Jan 26.
7. Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A. Ding S, etal., Neurobiol Aging. 2012 Jul;33(7):1389-99. doi: 10.1016/j.neurobiolaging.2010.11.021. Epub 2011 Jan 6.
8. Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes. GarcĂ­a-Cerro S, etal., Neurobiol Dis. 2017 Oct;106:76-88. doi: 10.1016/j.nbd.2017.06.010. Epub 2017 Jun 21.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII. Kentrup H, etal., J Biol Chem 1996 Feb 16;271(7):3488-95.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. DYRK1A-haploinsufficiency in mice causes autistic-like features and febrile seizures. Raveau M, etal., Neurobiol Dis. 2018 Feb;110:180-191. doi: 10.1016/j.nbd.2017.12.003. Epub 2017 Dec 6.
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Disruptive de novo mutations of DYRK1A lead to a syndromic form of autism and ID. van Bon BW, etal., Mol Psychiatry. 2016 Jan;21(1):126-32. doi: 10.1038/mp.2015.5. Epub 2015 Feb 24.
20. The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome. Wegiel J, etal., Acta Neuropathol. 2008 Oct;116(4):391-407. doi: 10.1007/s00401-008-0419-6. Epub 2008 Aug 12.
21. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion. Yin X, etal., J Biol Chem. 2012 Aug 31;287(36):30497-506. doi: 10.1074/jbc.M112.355412. Epub 2012 Jul 5.
22. Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice. Yin X, etal., Sci Rep. 2017 Apr 4;7(1):619. doi: 10.1038/s41598-017-00682-y.
Additional References at PubMed
PMID:9070862   PMID:15287745   PMID:15694837   PMID:15906374   PMID:17906291   PMID:19372220   PMID:19383720   PMID:19549690   PMID:19722700   PMID:19906449   PMID:20123978   PMID:20696760  
PMID:20736167   PMID:21252229   PMID:21273244   PMID:21470964   PMID:21709260   PMID:21878370   PMID:21965663   PMID:22110360   PMID:22250195   PMID:23415227   PMID:23665168   PMID:23809146  
PMID:23825664   PMID:24327345   PMID:26067684   PMID:27056896   PMID:27307198   PMID:28755400  


Genomics

Comparative Map Data
Dyrk1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21133,890,706 - 34,009,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,890,490 - 34,009,420 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,573,541 - 42,666,554 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01135,244,902 - 35,337,921 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01134,390,728 - 34,483,971 (+)NCBIRnor_WKY
Rnor_6.01134,858,339 - 34,958,733 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1134,865,532 - 34,956,536 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01138,453,019 - 38,550,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,879,733 - 34,970,998 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11134,935,975 - 35,027,241 (+)NCBI
Celera1134,444,072 - 34,535,020 (-)NCBICelera
Cytogenetic Map11q11NCBI
DYRK1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382137,365,573 - 37,526,358 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2137,365,573 - 37,526,358 (+)EnsemblGRCh38hg38GRCh38
GRCh372138,737,875 - 38,898,660 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362137,661,729 - 37,809,549 (+)NCBINCBI36Build 36hg18NCBI36
Build 342137,714,470 - 37,809,347NCBI
Celera2123,938,247 - 24,086,068 (+)NCBICelera
Cytogenetic Map21q22.13NCBI
HuRef2124,215,875 - 24,363,782 (+)NCBIHuRef
CHM1_12138,301,002 - 38,448,854 (+)NCBICHM1_1
T2T-CHM13v2.02135,747,888 - 35,908,739 (+)NCBIT2T-CHM13v2.0
Dyrk1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391694,370,637 - 94,496,378 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1694,370,869 - 94,496,376 (+)EnsemblGRCm39 Ensembl
GRCm381694,569,947 - 94,695,519 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1694,570,010 - 94,695,517 (+)EnsemblGRCm38mm10GRCm38
MGSCv371694,791,813 - 94,917,126 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361694,720,258 - 94,801,189 (+)NCBIMGSCv36mm8
Celera1695,699,096 - 95,783,175 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1655.3NCBI
Dyrk1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540736,453,098 - 36,589,382 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540736,456,628 - 36,588,940 (+)NCBIChiLan1.0ChiLan1.0
DYRK1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12137,092,172 - 37,231,916 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2137,137,253 - 37,231,987 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02123,729,204 - 23,878,820 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DYRK1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13132,564,970 - 32,655,232 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3132,511,502 - 32,652,572 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3131,572,154 - 31,719,378 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03131,812,898 - 31,959,979 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3131,811,351 - 31,960,042 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13131,682,502 - 31,829,001 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03131,695,751 - 31,842,602 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03132,186,102 - 32,332,696 (+)NCBIUU_Cfam_GSD_1.0
Dyrk1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497132,044,360 - 32,150,716 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365005,316,164 - 5,404,353 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365005,317,109 - 5,423,593 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYRK1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13201,009,480 - 201,159,948 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113201,008,506 - 201,159,946 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213211,096,538 - 211,247,962 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DYRK1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1281,318,509 - 81,467,227 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl281,425,902 - 81,467,677 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660549,164,197 - 9,315,412 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dyrk1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474526,180,864 - 26,315,234 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474526,180,858 - 26,316,848 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dyrk1a
339 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:359
Count of miRNA genes:210
Interacting mature miRNAs:254
Transcripts:ENSRNOT00000050342
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat

Markers in Region
D11Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,006,281 - 34,006,459 (+)MAPPERmRatBN7.2
Rnor_6.01134,955,595 - 34,955,772NCBIRnor6.0
Rnor_5.01138,547,374 - 38,547,551UniSTSRnor5.0
RGSC_v3.41134,970,059 - 34,970,236UniSTSRGSC3.4
Celera1134,444,834 - 34,445,011UniSTS
Cytogenetic Map11q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 56 40 19 40 8 11 74 35 41 11 8
Low 1 1 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC106913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC131528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X79769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000050342   ⟹   ENSRNOP00000042446
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1133,916,184 - 34,009,420 (+)Ensembl
Rnor_6.0 Ensembl1134,865,532 - 34,956,536 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103651   ⟹   ENSRNOP00000095263
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1133,971,575 - 34,009,415 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114109   ⟹   ENSRNOP00000096172
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1133,890,490 - 34,009,415 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117746   ⟹   ENSRNOP00000083937
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1133,972,363 - 34,009,420 (+)Ensembl
RefSeq Acc Id: NM_012791   ⟹   NP_036923
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21133,916,184 - 34,009,420 (+)NCBI
Rnor_6.01134,865,532 - 34,956,534 (+)NCBI
Rnor_5.01138,453,019 - 38,550,512 (+)NCBI
RGSC_v3.41134,879,733 - 34,970,998 (+)RGD
Celera1134,444,072 - 34,535,020 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088026   ⟹   XP_038943954
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21133,891,213 - 34,009,420 (+)NCBI
RefSeq Acc Id: XM_039088027   ⟹   XP_038943955
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21133,891,210 - 34,009,414 (+)NCBI
RefSeq Acc Id: XM_039088028   ⟹   XP_038943956
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21133,891,210 - 34,009,420 (+)NCBI
RefSeq Acc Id: XM_039088030   ⟹   XP_038943958
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21133,890,706 - 34,009,420 (+)NCBI
RefSeq Acc Id: XM_039088031   ⟹   XP_038943959
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21133,891,213 - 34,009,420 (+)NCBI
RefSeq Acc Id: XM_039088032   ⟹   XP_038943960
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21133,891,223 - 34,009,420 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036923   ⟸   NM_012791
- UniProtKB: Q63470 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000042446   ⟸   ENSRNOT00000050342
RefSeq Acc Id: XP_038943958   ⟸   XM_039088030
- Peptide Label: isoform X1
- UniProtKB: Q63470 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943956   ⟸   XM_039088028
- Peptide Label: isoform X1
- UniProtKB: Q63470 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943955   ⟸   XM_039088027
- Peptide Label: isoform X1
- UniProtKB: Q63470 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943954   ⟸   XM_039088026
- Peptide Label: isoform X1
- UniProtKB: Q63470 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038943959   ⟸   XM_039088031
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038943960   ⟸   XM_039088032
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000095263   ⟸   ENSRNOT00000103651
RefSeq Acc Id: ENSRNOP00000083937   ⟸   ENSRNOT00000117746
RefSeq Acc Id: ENSRNOP00000096172   ⟸   ENSRNOT00000114109
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63470-F1-model_v2 AlphaFold Q63470 1-763 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2528 AgrOrtholog
BIND 119589
  134466
BioCyc Gene G2FUF-21759 BioCyc
Ensembl Genes ENSRNOG00000001662 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000042446 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000083937 ENTREZGENE
  ENSRNOP00000083937.1 UniProtKB/TrEMBL
  ENSRNOP00000095263.1 UniProtKB/TrEMBL
  ENSRNOP00000096172 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000050342 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000103651.1 UniProtKB/TrEMBL
  ENSRNOT00000114109 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000117746 ENTREZGENE
  ENSRNOT00000117746.1 UniProtKB/TrEMBL
InterPro DYRK1A/B_MNB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKc_DYR1A/1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25255 UniProtKB/Swiss-Prot
NCBI Gene 25255 ENTREZGENE
PANTHER PTHR24058:SF121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dyrk1a PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218329
UniProt A0A8I5ZY45_RAT UniProtKB/TrEMBL
  A0A8I6GL29_RAT UniProtKB/TrEMBL
  DYR1A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Dyrk1a  dual specificity tyrosine phosphorylation regulated kinase 1A  Dyrk1a  dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Dyrk1a  dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A  Dyrk  Dual Specificity Yak1-related kinase  Symbol and Name updated 625702 APPROVED
2002-06-10 Dyrk  Dual Specificity Yak1-related kinase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease plays a role in the mental retardation associated with Downs syndrome 625468
gene_domains contains a kinase domain, a bipartite nuclear target sequence, a PEST (proline, glutamate, serine, and threonine) region, a 13-residue histidine repeat, and a serine/threonine repeat near the C-terminal end 625468
gene_function proline-directed serine/threonine kinase 625468
gene_process plays a dual role in regulating the interaction of dynamin 1 with amphiphysin 1 625468
gene_process may mediate the assembly of endocytic apparatus 625468
gene_product member of Dyrk-related genes family 625468
gene_product either 763 or 754 amino acids as a result of alternative splicing 625468