Dyrk1a (dual specificity tyrosine phosphorylation regulated kinase 1A) - Rat Genome Database

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Gene: Dyrk1a (dual specificity tyrosine phosphorylation regulated kinase 1A) Heterocephalus glaber
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Symbol: Dyrk1a
Name: dual specificity tyrosine phosphorylation regulated kinase 1A
RGD ID: 18903776
Description: ENCODES a protein that exhibits actin binding (ortholog); cyclin binding (ortholog); cytoskeletal protein binding (ortholog); INVOLVED IN amyloid-beta formation (ortholog); calcineurin-NFAT signaling cascade (ortholog); cardiac muscle hypertrophy (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 7 (ortholog); FOUND IN actin filament (ortholog); axon (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity tyrosine-phosphorylation-regulated kinase 1A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474526,180,864 - 26,315,234 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474526,180,858 - 26,316,848 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dyrk1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474526,180,864 - 26,315,234 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474526,180,858 - 26,316,848 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DYRK1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382137,365,573 - 37,526,358 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2137,365,573 - 37,526,358 (+)EnsemblGRCh38hg38GRCh38
GRCh372138,737,875 - 38,898,660 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362137,661,729 - 37,809,549 (+)NCBINCBI36Build 36hg18NCBI36
Build 342137,714,470 - 37,809,347NCBI
Celera2123,938,247 - 24,086,068 (+)NCBICelera
Cytogenetic Map21q22.13NCBI
HuRef2124,215,875 - 24,363,782 (+)NCBIHuRef
CHM1_12138,301,002 - 38,448,854 (+)NCBICHM1_1
T2T-CHM13v2.02135,747,888 - 35,908,739 (+)NCBIT2T-CHM13v2.0
Dyrk1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391694,370,770 - 94,496,378 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1694,370,869 - 94,496,376 (+)EnsemblGRCm39 Ensembl
GRCm381694,569,947 - 94,695,519 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1694,570,010 - 94,695,517 (+)EnsemblGRCm38mm10GRCm38
MGSCv371694,791,813 - 94,917,126 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361694,720,258 - 94,801,189 (+)NCBIMGSCv36mm8
Celera1695,699,096 - 95,783,175 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1655.3NCBI
Dyrk1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81147,360,824 - 47,479,033 (+)NCBIGRCr8
mRatBN7.21133,890,706 - 34,009,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,890,490 - 34,009,420 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,573,541 - 42,666,554 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01135,244,902 - 35,337,921 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01134,390,728 - 34,483,971 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01134,858,339 - 34,958,733 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1134,865,532 - 34,956,536 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01138,453,019 - 38,550,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,879,733 - 34,970,998 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11134,935,975 - 35,027,241 (+)NCBI
Celera1134,444,072 - 34,535,020 (-)NCBICelera
Cytogenetic Map11q11NCBI
Dyrk1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540736,453,098 - 36,589,382 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540736,456,628 - 36,588,940 (+)NCBIChiLan1.0ChiLan1.0
DYRK1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22233,475,597 - 33,629,787 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12128,339,782 - 28,489,307 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02123,729,204 - 23,878,820 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12137,092,172 - 37,231,916 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2137,137,253 - 37,231,987 (+)Ensemblpanpan1.1panPan2
DYRK1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13132,564,970 - 32,655,232 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3132,511,502 - 32,652,572 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3131,572,154 - 31,719,378 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03131,812,898 - 31,959,979 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3131,811,351 - 31,960,042 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13131,682,502 - 31,829,001 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03131,695,751 - 31,842,602 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03132,186,102 - 32,332,696 (+)NCBIUU_Cfam_GSD_1.0
Dyrk1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497132,044,360 - 32,150,716 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365005,316,164 - 5,404,353 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365005,317,109 - 5,423,593 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYRK1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13201,009,480 - 201,159,948 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113201,008,506 - 201,159,946 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213211,096,538 - 211,247,962 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DYRK1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1281,318,509 - 81,467,227 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl281,425,902 - 81,467,677 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660549,164,197 - 9,315,412 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000006913   ⟹   ENSHGLP00000006829
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474526,180,864 - 26,315,234 (-)Ensembl
RefSeq Acc Id: XM_004842379   ⟹   XP_004842436
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474526,180,858 - 26,263,835 (-)NCBI
RefSeq Acc Id: XM_004842380   ⟹   XP_004842437
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474526,180,858 - 26,315,165 (-)NCBI
RefSeq Acc Id: XM_004842381   ⟹   XP_004842438
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474526,180,858 - 26,313,874 (-)NCBI
RefSeq Acc Id: XM_004842382   ⟹   XP_004842439
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474526,180,858 - 26,316,848 (-)NCBI
RefSeq Acc Id: XM_004842383   ⟹   XP_004842440
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474526,180,858 - 26,276,049 (-)NCBI
RefSeq Acc Id: XM_021256259   ⟹   XP_021111918
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474526,180,858 - 26,249,794 (-)NCBI
RefSeq Acc Id: XM_021256260   ⟹   XP_021111919
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474526,180,858 - 26,315,282 (-)NCBI
RefSeq Acc Id: XM_021256261   ⟹   XP_021111920
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474526,180,858 - 26,249,790 (-)NCBI
RefSeq Acc Id: XM_021256262   ⟹   XP_021111921
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474526,180,858 - 26,287,819 (-)NCBI
RefSeq Acc Id: XP_004842439   ⟸   XM_004842382
- Peptide Label: isoform X5
- UniProtKB: G5AXI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111919   ⟸   XM_021256260
- Peptide Label: isoform X2
- UniProtKB: G5AXI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004842437   ⟸   XM_004842380
- Peptide Label: isoform X5
- UniProtKB: G5AXI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004842438   ⟸   XM_004842381
- Peptide Label: isoform X5
- UniProtKB: G5AXI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111921   ⟸   XM_021256262
- Peptide Label: isoform X5
- UniProtKB: G5AXI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004842440   ⟸   XM_004842383
- Peptide Label: isoform X5
- UniProtKB: G5AXI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004842436   ⟸   XM_004842379
- Peptide Label: isoform X4
- UniProtKB: G5AXI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111918   ⟸   XM_021256259
- Peptide Label: isoform X1
- UniProtKB: G5AXI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111920   ⟸   XM_021256261
- Peptide Label: isoform X3
- UniProtKB: G5AXI1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000006829   ⟸   ENSHGLT00000006913


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000004983 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000006913 ENTREZGENE
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  PKc_DYR1A/1B UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ser_Thr_dual-spec_kinase UniProtKB/TrEMBL
NCBI Gene Dyrk1a ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN KINASE UniProtKB/TrEMBL
  DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Protein kinase-like (PK-like) UniProtKB/TrEMBL
UniProt A0AAX6P2I9_HETGA UniProtKB/TrEMBL
  A0AAX6P340_HETGA UniProtKB/TrEMBL
  A0AAX6SSZ5_HETGA UniProtKB/TrEMBL
  A0AAX6STA7_HETGA UniProtKB/TrEMBL
  A0AAX6STV5_HETGA UniProtKB/TrEMBL
  G5AXI1 ENTREZGENE, UniProtKB/TrEMBL