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Gene: DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A) Homo sapiens
Symbol: DYRK1A
Name: dual specificity tyrosine phosphorylation regulated kinase 1A
RGD ID: 737237
Description: Exhibits cytoskeletal protein binding activity; identical protein binding activity; and protein kinase activity. Involved in amyloid-beta formation; positive regulation of RNA splicing; and protein phosphorylation. Localizes to cytoplasm and nucleus. Colocalizes with actin filament; microtubule; and neurofilament. Implicated in autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Biomarker of Down syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; dual specificity tyrosine-phosphorylation-regulated kinase 1A; dual specificity YAK1-related kinase; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; DYRK; DYRK1; hMNB; HP86; MNB; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; MRD7; protein kinase minibrain homolog; serine/threonine kinase MNB; serine/threonine-specific protein kinase
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2137,365,573 - 37,526,358 (+)EnsemblGRCh38hg38GRCh38
GRCh382137,365,573 - 37,526,358 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372138,739,859 - 38,887,679 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362137,661,729 - 37,809,549 (+)NCBINCBI36hg18NCBI36
Build 342137,714,470 - 37,809,347NCBI
Celera2123,938,247 - 24,086,068 (+)NCBI
Cytogenetic Map21q22.13NCBI
HuRef2124,215,875 - 24,363,782 (+)NCBIHuRef
CHM1_12138,301,002 - 38,448,854 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DYRK1A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737237
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.