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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2528
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dyrk1a
Name: dual specificity tyrosine phosphorylation regulated kinase 1A
Acc ID: CHEBI:69098
Term: licocoumarone
Definition: A member of the class of 1-benzofurans which consists of 1-benzofuran substituted by a hydroxy group at position 6, a methoxy group at position 4, a prenyl group at position 5 and a 2,4-dihydroxyphenyl group at position 2. It has been isolated from Glycyrrhiza uralensis.
Chemical ID: MESH:C000617177
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dyrk1amultiple interactionsISORGD:7372376480464CTDlicocoumarone binds to and results in decreased activity of DYRK1A proteinPMID:31838052
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