Hacd2 (3-hydroxyacyl-CoA dehydratase 2)

Gene: Hacd2 (3-hydroxyacyl-CoA dehydratase 2) Rattus norvegicus

Analyze

Symbol:

Hacd2

Name:

3-hydroxyacyl-CoA dehydratase 2

RGD ID:

1306337

Description:

Predicted to enable enzyme binding activity and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Predicted to be involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Orthologous to human HACD2 (3-hydroxyacyl-CoA dehydratase 2); PARTICIPATES IN unsaturated fatty acid biosynthetic pathway; INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; buspirone.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC102551408; LOC288058; protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; protein-tyrosine phosphatase-like member B; Ptplb; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2-like; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2-like

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HACD2 (3-hydroxyacyl-CoA dehydratase 2)	HGNC	Ensembl, HomoloGene, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Hacd2 (3-hydroxyacyl-CoA dehydratase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hacd2 (3-hydroxyacyl-CoA dehydratase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HACD2 (3-hydroxyacyl-CoA dehydratase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HACD2 (3-hydroxyacyl-CoA dehydratase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hacd2 (3-hydroxyacyl-CoA dehydratase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HACD2 (3-hydroxyacyl-CoA dehydratase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HACD2 (3-hydroxyacyl-CoA dehydratase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hacd2 (3-hydroxyacyl-CoA dehydratase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	HACD2 (3-hydroxyacyl-CoA dehydratase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Hacd2 (3-hydroxyacyl-CoA dehydratase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hacd2 (3-hydroxyacyl-CoA dehydratase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PHS1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Hacd1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	hpo-8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	79,175,470 - 79,268,975 (-)	NCBI		GRCr8
mRatBN7.2	11	65,667,671 - 65,762,903 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	65,670,281 - 65,762,889 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	74,493,218 - 74,584,605 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	67,155,521 - 67,247,060 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	66,186,803 - 66,277,005 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	68,985,497 - 68,990,023 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	68,894,445 - 68,989,988 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	71,984,627 - 72,076,335 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	67,489,819 - 67,581,576 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	67,547,407 - 67,639,377 (-)	NCBI
Celera	11	65,126,730 - 65,218,607 (-)	NCBI		Celera
Cytogenetic Map	11	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alkaptonuria (ISO)

familial hypocalciuric hypercalcemia (ISO)

Familial Thoracic Aortic Aneurysm 7 (ISO)

genetic disease (ISO)

Primary Lymphedema with Myelodysplasia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-diaminotoluene (ISO)

2,4-dinitrotoluene (EXP)

2-methylcholine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buspirone (EXP)

butanal (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

choline (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

clothianidin (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

doxorubicin (ISO)

ethanol (ISO)

finasteride (EXP)

folic acid (ISO)

formaldehyde (ISO)

geldanamycin (ISO)

gentamycin (EXP)

L-methionine (ISO)

mercury dichloride (ISO)

methylseleninic acid (ISO)

monosodium L-glutamate (ISO)

nickel atom (ISO)

oxaliplatin (EXP)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

quercetin (ISO)

resveratrol (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

thimerosal (ISO)

topotecan (EXP)

torcetrapib (ISO)

triclosan (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid elongation (IBA,ISO)

sphingolipid biosynthetic process (IBA,ISO)

very long-chain fatty acid biosynthetic process (IBA,ISO)

Cellular Component

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (IBA,IEA)

Molecular Function

3-hydroxyacyl-CoA dehydratase activity (IBA,ISO)

enzyme binding (ISO)

protein binding (ISO)

protein tyrosine phosphatase activity (ISO)

very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

unsaturated fatty acid biosynthetic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15024066	PMID:15632090	PMID:18554506

Genomics

Comparative Map Data

Hacd2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	79,175,470 - 79,268,975 (-)	NCBI		GRCr8
mRatBN7.2	11	65,667,671 - 65,762,903 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	65,670,281 - 65,762,889 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	74,493,218 - 74,584,605 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	67,155,521 - 67,247,060 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	66,186,803 - 66,277,005 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	68,985,497 - 68,990,023 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	68,894,445 - 68,989,988 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	71,984,627 - 72,076,335 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	67,489,819 - 67,581,576 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	67,547,407 - 67,639,377 (-)	NCBI
Celera	11	65,126,730 - 65,218,607 (-)	NCBI		Celera
Cytogenetic Map	11	q22	NCBI

HACD2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	123,491,554 - 123,585,053 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	123,490,820 - 123,585,053 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	123,210,401 - 123,303,900 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	124,693,091 - 124,786,726 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	121,620,589 - 121,710,855 (-)	NCBI		Celera
Cytogenetic Map	3	q21.1	NCBI
HuRef	3	120,585,854 - 120,675,943 (-)	NCBI		HuRef
CHM1_1	3	123,176,722 - 123,266,949 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	126,211,843 - 126,305,184 (-)	NCBI		T2T-CHM13v2.0

Hacd2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	34,842,791 - 34,929,560 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	34,842,798 - 34,929,547 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	35,022,421 - 35,109,190 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	35,022,428 - 35,109,177 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	35,022,507 - 35,109,261 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	34,942,168 - 35,028,922 (+)	NCBI		MGSCv36	mm8
Celera	16	35,490,337 - 35,577,166 (+)	NCBI		Celera
Cytogenetic Map	16	B3	NCBI
cM Map	16	24.54	NCBI

Hacd2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955427	22,642,478 - 22,734,271 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955427	22,642,509 - 22,733,170 (-)	NCBI	ChiLan1.0	ChiLan1.0

HACD2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	121,444,788 - 121,541,033 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	121,449,561 - 121,545,414 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	120,588,195 - 120,684,177 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	127,489,213 - 127,584,408 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

HACD2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	26,530,221 - 26,643,477 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	26,533,114 - 26,637,035 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	26,552,163 - 26,662,964 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	26,763,562 - 26,874,428 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	26,763,600 - 26,874,550 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	26,558,486 - 26,669,848 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	26,603,816 - 26,714,547 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	27,214,911 - 27,326,501 (-)	NCBI		UU_Cfam_GSD_1.0

Hacd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	127,706,184 - 127,796,663 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936725	1,614,622 - 1,705,132 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936725	1,614,637 - 1,705,111 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HACD2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	136,834,115 - 136,933,549 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	136,834,103 - 136,933,564 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	146,240,168 - 146,258,854 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HACD2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	57,285,948 - 57,379,894 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	57,322,657 - 57,381,683 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	108,966,635 - 109,066,981 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hacd2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624912	1,814,906 - 1,917,009 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624912	1,814,906 - 1,916,584 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Hacd2
426 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	24
Count of miRNA genes:	24
Interacting mature miRNAs:	24
Transcripts:	ENSRNOT00000003013
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	1	69446234	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	1041931	66113562	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	22959403	67959403	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	23280456	68280456	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	23280456	68280456	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	31239134	78851519	Rat
70180	BpQTLcluster10	Blood pressure QTL cluster 10	3.19		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	11	34918041	79918041	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	40946188	82566702	Rat
2312566	Glom20	Glomerulus QTL 20	3.6	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	44285759	82566702	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
4889859	Pur28	Proteinuria QTL 28	19.5	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	11	45459323	75190161	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	55136729	82993457	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat
631506	Bp104	Blood pressure QTL 104	2.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	59802794	82566545	Rat
70208	Niddm22	Non-insulin dependent diabetes mellitus QTL 22	3.61		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	59802794	82566553	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat

Markers in Region

BF396268

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	65,688,706 - 65,688,955 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	68,912,480 - 68,912,728	NCBI	Rnor6.0
Rnor_5.0	11	72,003,423 - 72,003,671	UniSTS	Rnor5.0
RGSC_v3.4	11	67,508,269 - 67,508,517	UniSTS	RGSC3.4
Celera	11	65,146,754 - 65,147,002	UniSTS
RH 3.4 Map	11	438.1	UniSTS
Cytogenetic Map	11	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	38	57	41	19	41			74	35	41	11
Low		5					8	11					8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001402103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_175003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248439	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000003013 ⟹ ENSRNOP00000003013

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	65,670,281 - 65,762,889 (-)	Ensembl
Rnor_6.0 Ensembl	11	68,894,445 - 68,989,988 (-)	Ensembl

RefSeq Acc Id:

NM_001402103 ⟹ NP_001389032

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	79,175,470 - 79,268,126 (-)	NCBI
mRatBN7.2	11	65,670,228 - 65,762,889 (-)	NCBI

RefSeq Acc Id:

NR_175003

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	79,175,470 - 79,268,126 (-)	NCBI
mRatBN7.2	11	65,670,228 - 65,762,889 (-)	NCBI

RefSeq Acc Id:

XM_006248439 ⟹ XP_006248501

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	79,175,470 - 79,268,975 (-)	NCBI
mRatBN7.2	11	65,667,671 - 65,762,902 (-)	NCBI

Sequence:

show sequence

CCTCCCTCCGCCCCCTCGCAGTACCCAGTGGGTCTGAGGTGCACGCGTGAGGAGAGCGGGCTGC
AGGCGCTTGACATGGCGGCAGCGGCGGCGACTGCAACGACCAAGGGGAATGGGGGCGGCAGTGG
ACGAGCCGGGGCTGGCGACAGCAGCGGCTCCCGGAAGAAGAAGGGCCCCGGGCCTGTGGCCACG
GCGTACCTGGTCATCTACAATGTGGTGATGACGGCGGGGTGGCTGGTGATAGCGGTTGGGCTGG
TGAGAGCATACCTGGCTAAGGGGAGCTACCATAGTCTTTATTATTCAATAGAAAAGCCTTTGAA
GTTCTTCCAGACAGGAGCCTTACTGGAGGTATGTTTGAGAGTTTCATCACTAATTTCAAATGTT
CTAAAGTGGAAAATATGCTGTTGCTAAGTATGATAGAATATATTGAAATATCCGTATCCTGGTT
GGATTTGCTTTAAATCTGGAAATTTTGCCTTATGAAATTGATGTCTTTGAAATCCTAAAAAATA
AAAAAAAAATCAAAATTCCATCTAATGTATTGCTTGGAATGTGTTTTATCTCCAACTTTATAGG
AAATCGAATGATGCAAACTTGTGTTAGGATTTTAAGGAATTCGAGGATTGCCCTGGTAGATTGT
TGACAGGTGGAGATAGTGTATTGGTGATAGACAGGAGAAACAGCAGGACCTGCCAGAGGCATCC
ACACTAACAAAGGCTTTGAAGGACAGCAGGTTGGCGGGTCCATGCTTGCCTCGGTCCTCCTTCC
TGAATCAATGTAGTTTGGGTTATAAGTATAGTTGGATTTTTGAGTTACAGCTGATAGTAATACA
ACTCAAACAATTTTAGGAATAAAGGGATCTTCTGGTTTGAAGCTGATAAAGATATAAAACTATG
GGATGGAGAGATAGCCCAGCAGTTAAGAGCCCTCGCTGATCTTCCAGAAAACCTAGGTTTGATT
CCCCCAGCACCCACATGGTGGGTCACAACTGTCAGTAGCTCCAGTTCCAGGGGATCTGATGCCC
TTCTTTTGACCCCCGAGGGCACCTGGCATGCATATGGAAAAACACTCATAAAGATAAGTTAGTA
AAATAATATTTTAAAAAGATTAAATGTTAACTTACAAAATGGAAGGAACCAGCTCAGGGTTGAG
AAGCAACGGTTTGACTTTGTTTCTCTTTGTGTGATGGTCTTAGGCTCTGCTAGTGTAGTTAGTC
CTGACATGGTGGGAAGAGGTTGGGTTTTCAGAGCCTCTGTGTCAGATACGGTACTAGGAAGGAC
TCTGGTTGGTCCTTTTTATACCAGCTTAGAGTCTTGCTTGTGGTGCTCACACTTGATCAGCATG
TAGAGCACATGTCCAT

hide sequence

RefSeq Acc Id:

XM_039088915 ⟹ XP_038944843

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	79,193,841 - 79,268,975 (-)	NCBI
mRatBN7.2	11	65,688,594 - 65,762,903 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001389032	(Get FASTA)	NCBI Sequence Viewer
	XP_006248501	(Get FASTA)	NCBI Sequence Viewer
	XP_038944843	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM11327	(Get FASTA)	NCBI Sequence Viewer
	EDM11328	(Get FASTA)	NCBI Sequence Viewer
	EDM11329	(Get FASTA)	NCBI Sequence Viewer
	EDM11330	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003013.8

RefSeq Acc Id:

ENSRNOP00000003013 ⟸ ENSRNOT00000003013

RefSeq Acc Id:	XP_006248501 ⟸ XM_006248439
- Peptide Label:	isoform X1
- Sequence:	show sequence MAAAAATATTKGNGGGSGRAGAGDSSGSRKKKGPGPVATAYLVIYNVVMTAGWLVIAVGLVRAY LAKGSYHSLYYSIEKPLKFFQTGALLEVCLRVSSLISNVLKWKICCC hide sequence

RefSeq Acc Id:	XP_038944843 ⟸ XM_039088915
- Peptide Label:	isoform X2

RefSeq Acc Id:

NP_001389032 ⟸ NM_001402103

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZHG0-F1-model_v2	AlphaFold	D3ZHG0	1-254	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698194

Promoter ID:

EPDNEW_R8717

Type:

initiation region

Name:

Hacd2_1

Description:

3-hydroxyacyl-CoA dehydratase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	68,990,004 - 68,990,064	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306337	AgrOrtholog
Ensembl Genes	ENSRNOG00000038761	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000003013	ENTREZGENE
	ENSRNOT00000003013.9	UniProtKB/TrEMBL
InterPro	Tyr_Pase-like_PTPLA	UniProtKB/TrEMBL
NCBI Gene	Hacd2	ENTREZGENE
PANTHER	PTHR11035	UniProtKB/TrEMBL
	VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE 2	UniProtKB/TrEMBL
Pfam	PTPLA	UniProtKB/TrEMBL
PhenoGen	Hacd2	PhenoGen
RatGTEx	ENSRNOG00000038761	RatGTEx
UniProt	D3ZHG0_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Hacd2	3-hydroxyacyl-CoA dehydratase 2	LOC102551408	very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2-like	Data merged from RGD:7603878	737654	PROVISIONAL
2015-02-04	Hacd2	3-hydroxyacyl-CoA dehydratase 2	Ptplb	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-12-18	LOC102551408	very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2013-05-24	Ptplb	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b	LOC690040	similar to protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b	Data merged from RGD:1585171	1643240	APPROVED
2008-04-30	Ptplb	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b	Ptplb_predicted	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b (predicted)	'predicted' is removed	2292626	APPROVED
2006-11-19	LOC690040	similar to protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-12	Ptplb_predicted	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)