B4galt4 (beta-1,4-galactosyltransferase 4) - Rat Genome Database

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Gene: B4galt4 (beta-1,4-galactosyltransferase 4) Rattus norvegicus
Analyze
Symbol: B4galt4
Name: beta-1,4-galactosyltransferase 4
RGD ID: 1307880
Description: Predicted to enable N-acetyllactosamine synthase activity. Predicted to be involved in glycosylation; keratan sulfate biosynthetic process; and lactosylceramide biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human B4GALT4 (beta-1,4-galactosyltransferase 4); PARTICIPATES IN keratan sulfate biosynthetic pathway; lacto-series glycosphingolipid metabolic pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: b4Gal-T4; beta-1,4-GalTase 4; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; beta4Gal-T4; lactotriaosylceramide beta-1,4-galactosyltransferase; LOC303923; N-acetyllactosamine synthase; nal synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21161,995,807 - 62,021,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1161,995,814 - 62,021,671 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1170,808,370 - 70,834,190 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,470,630 - 63,496,445 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,521,805 - 62,547,637 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,558,006 - 64,584,054 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,557,977 - 64,583,994 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01167,525,192 - 67,550,871 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,772,138 - 63,797,917 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11163,829,730 - 63,855,506 (-)NCBI
Celera1161,498,650 - 61,524,529 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334  


Genomics

Comparative Map Data
B4galt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21161,995,807 - 62,021,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1161,995,814 - 62,021,671 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1170,808,370 - 70,834,190 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,470,630 - 63,496,445 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,521,805 - 62,547,637 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,558,006 - 64,584,054 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,557,977 - 64,583,994 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01167,525,192 - 67,550,871 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,772,138 - 63,797,917 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11163,829,730 - 63,855,506 (-)NCBI
Celera1161,498,650 - 61,524,529 (-)NCBICelera
Cytogenetic Map11q21NCBI
B4GALT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383119,211,742 - 119,240,878 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3119,211,732 - 119,240,946 (-)EnsemblGRCh38hg38GRCh38
GRCh373118,930,589 - 118,959,725 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363120,413,279 - 120,442,442 (-)NCBINCBI36Build 36hg18NCBI36
Celera3117,339,081 - 117,368,232 (-)NCBICelera
Cytogenetic Map3q13.32NCBI
HuRef3116,306,059 - 116,335,214 (-)NCBIHuRef
CHM1_13118,894,016 - 118,923,181 (-)NCBICHM1_1
T2T-CHM13v2.03121,931,449 - 121,960,629 (-)NCBIT2T-CHM13v2.0
B4galt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391638,562,600 - 38,589,416 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1638,562,626 - 38,589,411 (+)EnsemblGRCm39 Ensembl
GRCm381638,742,220 - 38,769,054 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,742,264 - 38,769,049 (+)EnsemblGRCm38mm10GRCm38
MGSCv371638,742,377 - 38,769,158 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361638,661,614 - 38,688,176 (+)NCBIMGSCv36mm8
Celera1639,147,148 - 39,174,186 (+)NCBICelera
Cytogenetic Map16B4NCBI
cM Map1626.87NCBI
B4galt4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542718,963,396 - 18,985,479 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542718,964,578 - 18,982,090 (-)NCBIChiLan1.0ChiLan1.0
B4GALT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan13117,188,713 - 117,206,828 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03116,329,595 - 116,358,779 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13123,241,676 - 123,270,831 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,241,676 - 123,270,806 (-)Ensemblpanpan1.1panPan2
B4GALT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13322,903,842 - 22,920,955 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3322,904,149 - 22,920,956 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3322,935,572 - 22,963,143 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03323,141,256 - 23,169,319 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3323,140,761 - 23,169,352 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13322,944,497 - 22,972,114 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03322,982,171 - 23,009,839 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03323,549,708 - 23,577,503 (-)NCBIUU_Cfam_GSD_1.0
B4galt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602131,280,283 - 131,329,566 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365366,215,152 - 6,241,877 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365366,215,221 - 6,241,828 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
B4GALT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,969,602 - 141,003,929 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113140,969,561 - 141,003,936 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213150,277,223 - 150,279,556 (+)NCBISscrofa10.2Sscrofa10.2susScr3
B4GALT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12261,600,143 - 61,629,857 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2261,604,044 - 61,630,420 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041104,706,030 - 104,735,691 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
B4galt4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473128,939,838 - 28,971,652 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473128,929,599 - 28,972,417 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in B4galt4
206 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:475
Count of miRNA genes:244
Interacting mature miRNAs:291
Transcripts:ENSRNOT00000004289
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 50 14 30 11
Low 2 43 46 30 19 30 8 11 24 21 11 8
Below cutoff 11 11 11

Sequence


RefSeq Acc Id: ENSRNOT00000004289   ⟹   ENSRNOP00000004289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1161,995,814 - 62,021,671 (-)Ensembl
Rnor_6.0 Ensembl1164,557,977 - 64,583,994 (-)Ensembl
RefSeq Acc Id: NM_001012018   ⟹   NP_001012018
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21161,995,811 - 62,021,638 (-)NCBI
Rnor_6.01164,558,010 - 64,583,969 (-)NCBI
Rnor_5.01167,525,192 - 67,550,871 (+)NCBI
RGSC_v3.41163,772,138 - 63,797,917 (-)RGD
Celera1161,498,650 - 61,524,529 (-)RGD
Sequence:
RefSeq Acc Id: XM_017598000   ⟹   XP_017453489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21161,995,807 - 62,021,751 (-)NCBI
Rnor_6.01164,558,006 - 64,584,054 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005491029
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21161,996,734 - 62,021,637 (-)NCBI
RefSeq Acc Id: XR_005491030
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21161,996,705 - 62,021,637 (-)NCBI
RefSeq Acc Id: NP_001012018   ⟸   NM_001012018
- UniProtKB: Q66HH1 (UniProtKB/Swiss-Prot),   A6IR55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453489   ⟸   XM_017598000
- Peptide Label: isoform X1
- UniProtKB: Q66HH1 (UniProtKB/Swiss-Prot),   A6IR55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004289   ⟸   ENSRNOT00000004289
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HH1-F1-model_v2 AlphaFold Q66HH1 1-344 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698162
Promoter ID:EPDNEW_R8686
Type:initiation region
Name:B4galt4_1
Description:beta-1,4-galactosyltransferase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01164,583,978 - 64,584,038EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307880 AgrOrtholog
BioCyc Gene G2FUF-21284 BioCyc
Ensembl Genes ENSRNOG00000003114 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055015909 UniProtKB/Swiss-Prot
  ENSRNOG00060007813 UniProtKB/Swiss-Prot
  ENSRNOG00065019064 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004289 ENTREZGENE
  ENSRNOT00000004289.7 UniProtKB/Swiss-Prot
  ENSRNOT00055027061 UniProtKB/Swiss-Prot
  ENSRNOT00060012890 UniProtKB/Swiss-Prot
  ENSRNOT00065032060 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096554 IMAGE-MGC_LOAD
InterPro Galactosyl_T UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactosyl_T_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactosyl_T_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-diphossugar_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:303923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93698 IMAGE-MGC_LOAD
NCBI Gene 303923 ENTREZGENE
PANTHER BETA-1,4-GALACTOSYLTRANSFERASE UniProtKB/TrEMBL
  BETA-1,4-GALACTOSYLTRANSFERASE 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19300 UniProtKB/Swiss-Prot
Pfam Glyco_transf_7C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_transf_7N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen B4galt4 PhenoGen
PRINTS B14GALTRFASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003114 RatGTEx
  ENSRNOG00055015909 RatGTEx
  ENSRNOG00060007813 RatGTEx
  ENSRNOG00065019064 RatGTEx
Superfamily-SCOP Nucleotide-diphospho-sugar transferases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IR55 ENTREZGENE, UniProtKB/TrEMBL
  B4GT4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 B4galt4  beta-1,4-galactosyltransferase 4  B4galt4  UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 B4galt4  UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4  B4galt4_predicted  UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 B4galt4_predicted  UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED