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Gene: Tfrc (transferrin receptor) Rattus norvegicus
Symbol: Tfrc
Name: transferrin receptor
RGD ID: 70488
Description: Exhibits Hsp70 protein binding activity; chaperone binding activity; and transferrin receptor activity. Involved in several processes, including response to copper ion; response to manganese ion; and response to retinoic acid. Localizes to several cellular components, including cell surface; extracellular exosome; and recycling endosome membrane. Biomarker of duodenal ulcer; hepatocellular carcinoma; muscular atrophy; non-alcoholic fatty liver disease; and nutrition disease. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to human TFRC (transferrin receptor); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; iron uptake pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: tfR; tfR1; TR; transferrin receptor protein 1; Trfr
Homo sapiens (human) : TFRC (transferrin receptor)  HGNC  Alliance
Mus musculus (house mouse) : Tfrc (transferrin receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tfrc (transferrin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : TFRC (transferrin receptor)
Canis lupus familiaris (dog) : TFRC (transferrin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tfrc (transferrin receptor)
Sus scrofa (pig) : TFRC (transferrin receptor)
Chlorocebus sabaeus (African green monkey) : TFRC (transferrin receptor)
Heterocephalus glaber (naked mole-rat) : Tfrc (transferrin receptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01171,397,423 - 71,419,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,397,383 - 71,419,223 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,479,841 - 74,502,561 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,976,258 - 69,998,098 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11170,034,788 - 70,049,347 (-)NCBI
Celera1167,596,761 - 67,618,555 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tfrc
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70488
Created: 2002-05-02
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.