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Gene: Crkl (CRK like proto-oncogene, adaptor protein) Rattus norvegicus
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Symbol: Crkl
Name: CRK like proto-oncogene, adaptor protein
Description: Predicted to have identical protein binding activity and phosphotyrosine residue binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; nervous system development; and regulation of protein phosphorylation. Localizes to the cytoplasm. Human ortholog(s) of this gene implicated in chronic myeloid leukemia. Orthologous to human CRKL (CRK like proto-oncogene, adaptor protein); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; erythropoietin signaling pathway; insulin-like growth factor signaling pathway; INTERACTS WITH ammonium chloride; bisphenol A; Brodifacoum.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: crk-like protein; LOC287942; v-crk avian sarcoma virus CT10 oncogene homolog-like; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v-crk sarcoma virus CT10 oncogene homolog-like
Orthologs:
Homo sapiens (human) : CRKL (CRK like proto-oncogene, adaptor protein)  HGNC  Alliance
Mus musculus (house mouse) : Crkl (v-crk avian sarcoma virus CT10 oncogene homolog-like)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crkl (CRK like proto-oncogene, adaptor protein)
Pan paniscus (bonobo/pygmy chimpanzee) : CRKL (CRK like proto-oncogene, adaptor protein)
Canis lupus familiaris (dog) : CRKL (CRK like proto-oncogene, adaptor protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crkl (CRK like proto-oncogene, adaptor protein)
Sus scrofa (pig) : CRKL (CRK like proto-oncogene, adaptor protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01187,338,606 - 87,356,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01190,397,653 - 90,408,448 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,520,244 - 85,554,667 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11185,560,841 - 85,595,264 (-)NCBI
Celera1182,297,248 - 82,331,672 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Crkl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308531
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.