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Gene: Crkl (CRK like proto-oncogene, adaptor protein) Rattus norvegicus
Symbol: Crkl
Name: CRK like proto-oncogene, adaptor protein
Description: Predicted to have identical protein binding activity and phosphotyrosine residue binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; nervous system development; and regulation of protein phosphorylation. Localizes to the cytoplasm. Human ortholog(s) of this gene implicated in chronic myeloid leukemia. Orthologous to human CRKL (CRK like proto-oncogene, adaptor protein); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; erythropoietin signaling pathway; insulin-like growth factor signaling pathway; INTERACTS WITH ammonium chloride; bisphenol A; Brodifacoum.
Type: protein-coding
Also known as: crk-like protein; LOC287942; v-crk avian sarcoma virus CT10 oncogene homolog-like; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v-crk sarcoma virus CT10 oncogene homolog-like
Homo sapiens (human) : CRKL (CRK like proto-oncogene, adaptor protein)  HGNC  Alliance
Mus musculus (house mouse) : Crkl (v-crk avian sarcoma virus CT10 oncogene homolog-like)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crkl (CRK like proto-oncogene, adaptor protein)
Pan paniscus (bonobo/pygmy chimpanzee) : CRKL (CRK like proto-oncogene, adaptor protein)
Canis lupus familiaris (dog) : CRKL (CRK like proto-oncogene, adaptor protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crkl (CRK like proto-oncogene, adaptor protein)
Sus scrofa (pig) : CRKL (CRK like proto-oncogene, adaptor protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01187,338,606 - 87,356,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01190,397,653 - 90,408,448 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,520,244 - 85,554,667 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11185,560,841 - 85,595,264 (-)NCBI
Celera1182,297,248 - 82,331,672 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Crkl
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308531
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.