Fgd4 (FYVE, RhoGEF and PH domain containing 4) - Rat Genome Database

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Gene: Fgd4 (FYVE, RhoGEF and PH domain containing 4) Rattus norvegicus
Analyze
Symbol: Fgd4
Name: FYVE, RhoGEF and PH domain containing 4
RGD ID: 708357
Description: Enables actin filament binding activity. Involved in positive regulation of JNK cascade and regulation of cell shape. Predicted to be located in filopodium and lamellipodium. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4H. Orthologous to human FGD4 (FYVE, RhoGEF and PH domain containing 4); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: actin filament-binding protein frabin; actin-filament binding protein frabin; FGD1-related F-actin-binding protein; FYVE, RhoGEF and PH domain-containing protein 4; LOC108352368; uncharacterized LOC108352368
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,904,182 - 98,055,190 (+)NCBIGRCr8
mRatBN7.21184,399,989 - 84,551,013 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,399,816 - 84,546,972 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,183,216 - 93,280,301 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,844,359 - 85,941,442 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,897,963 - 84,995,041 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,699,222 - 88,796,677 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,699,222 - 88,796,677 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,755,139 - 91,851,321 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,700,118 - 86,767,928 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,740,714 - 86,808,525 (-)NCBI
Celera1183,195,465 - 83,292,853 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
indometacin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
melphalan  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
cytoskeleton  (IEA)
filopodium  (IEA,ISO)
lamellipodium  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-terminal kinase. Obaishi H, etal., J Biol Chem 1998 Jul 24;273(30):18697-700.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10464238   PMID:11527409   PMID:12477932   PMID:17564959  


Genomics

Comparative Map Data
Fgd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,904,182 - 98,055,190 (+)NCBIGRCr8
mRatBN7.21184,399,989 - 84,551,013 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,399,816 - 84,546,972 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,183,216 - 93,280,301 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,844,359 - 85,941,442 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,897,963 - 84,995,041 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,699,222 - 88,796,677 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,699,222 - 88,796,677 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,755,139 - 91,851,321 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,700,118 - 86,767,928 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,740,714 - 86,808,525 (-)NCBI
Celera1183,195,465 - 83,292,853 (+)NCBICelera
Cytogenetic Map11q23NCBI
FGD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381232,399,558 - 32,646,050 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1232,399,558 - 32,646,050 (+)EnsemblGRCh38hg38GRCh38
GRCh371232,552,492 - 32,798,984 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361232,546,361 - 32,684,940 (+)NCBINCBI36Build 36hg18NCBI36
Build 341232,546,360 - 32,684,940NCBI
Celera1212,475,281 - 12,619,210 (+)NCBICelera
Cytogenetic Map12p11.21NCBI
HuRef1232,407,492 - 32,551,291 (+)NCBIHuRef
CHM1_11232,621,603 - 32,765,483 (+)NCBICHM1_1
T2T-CHM13v2.01232,275,797 - 32,522,311 (+)NCBIT2T-CHM13v2.0
Fgd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,234,774 - 16,418,400 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,234,781 - 16,418,413 (-)EnsemblGRCm39 Ensembl
GRCm381616,416,910 - 16,600,534 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,416,917 - 16,600,549 (-)EnsemblGRCm38mm10GRCm38
MGSCv371616,422,071 - 16,560,289 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361616,335,541 - 16,473,759 (-)NCBIMGSCv36mm8
Celera1616,993,276 - 17,131,405 (-)NCBICelera
Cytogenetic Map16A2- A3NCBI
cM Map1610.18NCBI
Fgd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555053,099,672 - 3,239,950 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555053,108,131 - 3,314,040 (-)NCBIChiLan1.0ChiLan1.0
FGD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21064,103,468 - 64,351,914 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11264,099,864 - 64,348,309 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01253,574,573 - 53,822,971 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11256,177,209 - 56,421,662 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1256,181,565 - 56,421,810 (-)Ensemblpanpan1.1panPan2
FGD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12716,252,405 - 16,464,099 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2716,254,542 - 16,464,112 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2729,959,925 - 30,175,525 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02716,432,262 - 16,643,309 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2716,437,077 - 16,643,512 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12716,239,925 - 16,454,669 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02716,272,975 - 16,488,424 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02730,109,074 - 30,323,691 (+)NCBIUU_Cfam_GSD_1.0
Fgd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494576,841,846 - 77,044,093 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366073,679,887 - 3,877,470 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366073,675,217 - 3,796,329 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl541,680,452 - 41,879,062 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1541,683,265 - 41,879,197 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2544,933,765 - 44,960,137 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11131,831,051 - 32,080,267 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660692,825,191 - 3,084,236 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247783,498,436 - 3,743,312 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247783,509,546 - 3,743,213 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fgd4
790 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:150
Count of miRNA genes:126
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000002491
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 8 5 8 72 8 9 8
Low 3 40 49 33 14 33 8 10 2 27 32 3 8
Below cutoff 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078367   ⟹   ENSRNOP00000072359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1184,399,816 - 84,546,972 (+)Ensembl
Rnor_6.0 Ensembl1188,732,381 - 88,795,399 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084177   ⟹   ENSRNOP00000074767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1184,449,241 - 84,546,972 (+)Ensembl
Rnor_6.0 Ensembl1188,699,222 - 88,796,677 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100508   ⟹   ENSRNOP00000092594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1184,430,398 - 84,546,972 (+)Ensembl
RefSeq Acc Id: NM_001415054   ⟹   NP_001401983
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,904,182 - 98,055,190 (+)NCBI
mRatBN7.21184,399,989 - 84,551,008 (+)NCBI
RefSeq Acc Id: NM_001415055   ⟹   NP_001401984
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,940,821 - 98,055,190 (+)NCBI
mRatBN7.21184,436,629 - 84,551,008 (+)NCBI
RefSeq Acc Id: XM_039087982   ⟹   XP_038943910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,934,673 - 98,055,188 (+)NCBI
mRatBN7.21184,430,471 - 84,551,013 (+)NCBI
RefSeq Acc Id: XM_039087984   ⟹   XP_038943912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,962,618 - 98,055,188 (+)NCBI
mRatBN7.21184,458,427 - 84,551,013 (+)NCBI
RefSeq Acc Id: XM_063270283   ⟹   XP_063126353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81197,986,627 - 98,055,188 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000072359   ⟸   ENSRNOT00000078367
RefSeq Acc Id: ENSRNOP00000074767   ⟸   ENSRNOT00000084177
RefSeq Acc Id: XP_038943910   ⟸   XM_039087982
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GK89 (UniProtKB/TrEMBL),   A6JSP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943912   ⟸   XM_039087984
- Peptide Label: isoform X2
- UniProtKB: O88387 (UniProtKB/Swiss-Prot),   A6JSQ0 (UniProtKB/TrEMBL),   A0A0G2K8X0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092594   ⟸   ENSRNOT00000100508
RefSeq Acc Id: NP_001401983   ⟸   NM_001415054
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K2S8 (UniProtKB/TrEMBL),   A6JSP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001401984   ⟸   NM_001415055
- Peptide Label: isoform 2
- UniProtKB: O88387 (UniProtKB/Swiss-Prot),   A6JSQ0 (UniProtKB/TrEMBL),   A0A0G2K8X0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126353   ⟸   XM_063270283
- Peptide Label: isoform X3
Protein Domains
DH   FYVE-type   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88387-F1-model_v2 AlphaFold O88387 1-766 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708357 AgrOrtholog
BioCyc Gene G2FUF-20553 BioCyc
Ensembl Genes ENSRNOG00000059491 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055003163 UniProtKB/Swiss-Prot
  ENSRNOG00060002642 UniProtKB/Swiss-Prot
  ENSRNOG00065008509 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000078367 ENTREZGENE
  ENSRNOT00000078367.2 UniProtKB/TrEMBL
  ENSRNOT00000084177 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000084177.2 UniProtKB/Swiss-Prot
  ENSRNOT00000100508.1 UniProtKB/TrEMBL
  ENSRNOT00055004930 UniProtKB/Swiss-Prot
  ENSRNOT00060004232 UniProtKB/Swiss-Prot
  ENSRNOT00065013507 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FDG4_N_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FGD1-4_PH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246174 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 246174 ENTREZGENE
PANTHER FACIOGENITAL DYSPLASIA PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fgd4 PhenoGen
PROSITE DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059491 RatGTEx
  ENSRNOG00055003163 RatGTEx
  ENSRNOG00060002642 RatGTEx
  ENSRNOG00065008509 RatGTEx
SMART FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
UniProt A0A0G2K2S8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K8X0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GK89 ENTREZGENE, UniProtKB/TrEMBL
  A6JSP9 ENTREZGENE, UniProtKB/TrEMBL
  A6JSQ0 ENTREZGENE, UniProtKB/TrEMBL
  A6JSQ1_RAT UniProtKB/TrEMBL
  A6JSQ2_RAT UniProtKB/TrEMBL
  A6JSQ3_RAT UniProtKB/TrEMBL
  FGD4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fgd4  FYVE, RhoGEF and PH domain containing 4  LOC108352368  uncharacterized LOC108352368  Data merged from RGD:11362447 737654 PROVISIONAL
2016-08-02 LOC108352368  uncharacterized LOC108352368      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-01-09 Fgd4  FYVE, RhoGEF and PH domain containing 4  LOC246174  actin-filament binding protein frabin  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology has similarity in domain organization to human FGD1, whose mutation causes faciogenital dysplasia or Aarskog-Scott syndrome 1299389