(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:737072 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ITSN1 mRNA CTD PMID:22079256 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:1332367 6480464 [2 more ... CTD PMID:25510870 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO RGD:737072 6480464 2 more ... CTD PMID:23146750 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:1332367 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:737072 6480464 Tetrachlorodibenzodioxin results in increased expression of ITSN1 mRNA CTD PMID:21296121 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of ITSN1 mRNA CTD PMID:21346803 2-butoxyethanol increases expression ISO RGD:1332367 6480464 n-butoxyethanol results in increased expression of ITSN1 mRNA CTD PMID:19812364 2-methylcholine affects expression ISO RGD:737072 6480464 beta-methylcholine affects the expression of ITSN1 mRNA CTD PMID:21179406 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO RGD:737072 6480464 3 more ... CTD PMID:23146750 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:23196670 3,4-methylenedioxymethamphetamine increases expression ISO RGD:1332367 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of ITSN1 mRNA CTD PMID:20188158 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1332367 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of ITSN1 mRNA CTD PMID:26251327 3,4-methylenedioxymethamphetamine increases methylation ISO RGD:1332367 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased methylation of ITSN1 promoter CTD PMID:26251327 4-hydroxynon-2-enal decreases expression ISO RGD:737072 6480464 4-hydroxy-2-nonenal results in decreased expression of ITSN1 mRNA CTD PMID:12419474 5-fluorouracil affects response to substance ISO RGD:737072 6480464 ITSN1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of ITSN1 mRNA CTD PMID:28959563 aflatoxin B1 decreases expression ISO RGD:737072 6480464 Aflatoxin B1 results in decreased expression of ITSN1 mRNA CTD PMID:21641981 aflatoxin B1 increases methylation ISO RGD:737072 6480464 Aflatoxin B1 results in increased methylation of ITSN1 gene, Aflatoxin B1 results in increased methylation of ITSN1 intron CTD PMID:27153756 , PMID:30157460 aflatoxin B2 increases methylation ISO RGD:737072 6480464 aflatoxin B2 results in increased methylation of ITSN1 intron CTD PMID:30157460 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of ITSN1 mRNA CTD PMID:16483693 Aroclor 1254 decreases expression ISO RGD:1332367 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of ITSN1 mRNA CTD PMID:23650126 benzo[a]pyrene decreases expression ISO RGD:737072 6480464 Benzo(a)pyrene results in decreased expression of ITSN1 mRNA CTD PMID:20064835 benzo[a]pyrene affects methylation ISO RGD:737072 6480464 Benzo(a)pyrene affects the methylation of ITSN1 intron CTD PMID:30157460 benzo[a]pyrene decreases expression ISO RGD:1332367 6480464 Benzo(a)pyrene results in decreased expression of ITSN1 mRNA CTD PMID:20713471 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:737072 6480464 7 more ... CTD PMID:19150397 benzo[e]pyrene increases methylation ISO RGD:737072 6480464 benzo(e)pyrene results in increased methylation of ITSN1 intron CTD PMID:30157460 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of ITSN1 mRNA CTD PMID:25181051 butanal decreases expression ISO RGD:737072 6480464 butyraldehyde results in decreased expression of ITSN1 mRNA CTD PMID:26079696 C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of ITSN1 mRNA CTD PMID:19167457 carbon nanotube decreases expression ISO RGD:1332367 6480464 Nanotubes, Carbon analog results in decreased expression of ITSN1 mRNA, Nanotubes, Carbon results in decreased expression of ITSN1 mRNA CTD PMID:25554681 cisplatin decreases expression ISO RGD:737072 6480464 Cisplatin results in decreased expression of ITSN1 mRNA CTD PMID:27392435 clobetasol decreases expression ISO RGD:1332367 6480464 Clobetasol results in decreased expression of ITSN1 mRNA CTD PMID:27462272 cobalt dichloride decreases expression ISO RGD:737072 6480464 cobaltous chloride results in decreased expression of ITSN1 mRNA CTD PMID:19320972 cobalt dichloride increases expression ISO RGD:737072 6480464 cobaltous chloride results in increased expression of ITSN1 mRNA CTD PMID:19376846 copper atom multiple interactions ISO RGD:1332367 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of ITSN1 mRNA CTD PMID:15467011 copper(0) multiple interactions ISO RGD:1332367 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of ITSN1 mRNA CTD PMID:15467011 crocidolite asbestos multiple interactions ISO RGD:1332367 6480464 Asbestos, Crocidolite inhibits the reaction [SPARC gene mutant form results in increased expression of ITSN1 mRNA] CTD PMID:19446018 crocidolite asbestos decreases expression ISO RGD:737072 6480464 Asbestos, Crocidolite results in decreased expression of ITSN1 mRNA CTD PMID:29523930 crocidolite asbestos increases expression ISO RGD:1332367 6480464 Asbestos, Crocidolite results in increased expression of ITSN1 mRNA CTD PMID:19446018 cyclosporin A decreases expression ISO RGD:737072 6480464 Cyclosporine results in decreased expression of ITSN1 mRNA CTD PMID:20106945 cyclosporin A decreases expression ISO RGD:1332367 6480464 Cyclosporine results in decreased expression of ITSN1 mRNA CTD PMID:19770486 decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of ITSN1 mRNA CTD PMID:23640034 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of ITSN1 mRNA CTD PMID:20032058 dexamethasone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of ITSN1 mRNA] CTD PMID:20032058 dibutyl phthalate increases expression ISO RGD:1332367 6480464 Dibutyl Phthalate results in increased expression of ITSN1 mRNA CTD PMID:21266533 ethanol multiple interactions ISO RGD:1332367 6480464 Ethanol affects the expression of and affects the splicing of ITSN1 mRNA CTD PMID:30319688 ethanol increases expression ISO RGD:1332367 6480464 Ethanol results in increased expression of ITSN1 mRNA CTD PMID:30319688 ethanol affects splicing ISO RGD:1332367 6480464 Ethanol affects the splicing of ITSN1 mRNA CTD PMID:30319688 formaldehyde decreases expression ISO RGD:737072 6480464 Formaldehyde results in decreased expression of ITSN1 mRNA CTD PMID:23649840 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of ITSN1 mRNA CTD PMID:22061828 hexadecanoic acid increases phosphorylation ISO RGD:737072 6480464 Palmitic Acid results in increased phosphorylation of ITSN1 protein CTD PMID:28073184 hydralazine multiple interactions ISO RGD:737072 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of ITSN1 mRNA CTD PMID:17183730 methapyrilene increases methylation ISO RGD:737072 6480464 Methapyrilene results in increased methylation of ITSN1 intron CTD PMID:30157460 methoxychlor increases methylation EXP 6480464 Methoxychlor results in increased methylation of ITSN1 gene CTD PMID:23303685 nickel atom increases expression ISO RGD:1332367 6480464 Nickel results in increased expression of ITSN1 mRNA CTD PMID:18922574 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of ITSN1 mRNA CTD PMID:25729387 perfluorooctanoic acid decreases expression ISO RGD:1332367 6480464 perfluorooctanoic acid results in decreased expression of ITSN1 protein CTD PMID:28126411 phenobarbital affects expression ISO RGD:1332367 6480464 Phenobarbital affects the expression of ITSN1 mRNA CTD PMID:23091169 pirinixic acid decreases expression ISO RGD:1332367 6480464 pirinixic acid results in decreased expression of ITSN1 mRNA CTD PMID:18445702 potassium chromate decreases expression ISO RGD:737072 6480464 potassium chromate(VI) results in decreased expression of ITSN1 mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:737072 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ITSN1 mRNA CTD PMID:22079256 quercetin decreases expression ISO RGD:737072 6480464 Quercetin results in decreased expression of ITSN1 mRNA CTD PMID:21632981 sodium fluoride increases expression ISO RGD:1332367 6480464 Sodium Fluoride results in increased expression of ITSN1 mRNA CTD PMID:27862939 tert-butyl hydroperoxide decreases expression ISO RGD:737072 6480464 tert-Butylhydroperoxide results in decreased expression of ITSN1 mRNA CTD PMID:12419474 testosterone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of ITSN1 mRNA] CTD PMID:20032058 tetrachloromethane affects expression ISO RGD:1332367 6480464 Carbon Tetrachloride affects the expression of ITSN1 mRNA CTD PMID:17484886 tetraphene decreases expression ISO RGD:1332367 6480464 benz(a)anthracene results in decreased expression of ITSN1 mRNA CTD PMID:26377693 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of ITSN1 mRNA CTD PMID:23411599 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of ITSN1 mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of ITSN1 mRNA CTD PMID:25729387 valproic acid multiple interactions ISO RGD:737072 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of ITSN1 mRNA CTD PMID:17183730 valproic acid decreases expression ISO RGD:737072 6480464 Valproic Acid results in decreased expression of ITSN1 mRNA CTD PMID:29154799 valproic acid affects expression ISO RGD:737072 6480464 Valproic Acid affects the expression of ITSN1 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:737072 6480464 Valproic Acid results in increased expression of ITSN1 mRNA CTD PMID:23179753 more ... valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of ITSN1 mRNA CTD PMID:29427782
Biological Process brain development IEP 69862 RGD cellular protein localization IEA UniProtKB:Q15811 , ensembl:ENSP000003707191600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular protein localization ISO RGD:737072 1624291 (PMID:29887380) RGD PMID:29887380 exocytosis IEA UniProtKB-KW:KW-0268 1600115 GO_REF:0000037 UniProt GO_REF:0000037 negative regulation of neuron apoptotic process ISO RGD:1332367 1624291 (MGI:MGI:3768571, PMID:17875942) RGD MGI:MGI:3768571 , PMID:17875942 negative regulation of neuron apoptotic process IEA UniProtKB:Q9Z0R4 , ensembl:ENSMUSP000001096351600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of caveolin-mediated endocytosis IMP 13461864 RGD positive regulation of dendritic spine development IMP 13461864 RGD positive regulation of growth hormone secretion IMP 13461861 RGD positive regulation of kinase activity IEA GO:0019209 1600115 GO_REF:0000108 GOC GO_REF:0000108 positive regulation of protein kinase B signaling ISO RGD:1332367 1624291 (MGI:MGI:3768571, PMID:17875942) RGD MGI:MGI:3768571 , PMID:17875942 positive regulation of protein kinase B signaling IEA UniProtKB:Q9Z0R4 , ensembl:ENSMUSP000001096351600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein transport IEA UniProtKB-KW:KW-0653 1600115 GO_REF:0000037 UniProt GO_REF:0000037 regulation of modification of postsynaptic actin cytoskeleton IDA 13461864 PMID:19258322 SynGO regulation of modification of postsynaptic actin cytoskeleton IMP 13461864 PMID:19258322 SynGO regulation of Rho protein signal transduction IEA InterPro:IPR000219 1600115 GO_REF:0000002 InterPro GO_REF:0000002 small GTPase mediated signal transduction ISO RGD:1332367 1624291 (MGI:MGI:2158954, PMID:11744688) RGD MGI:MGI:2158954 , PMID:11744688 small GTPase mediated signal transduction IEA UniProtKB:Q9Z0R4 , ensembl:ENSMUSP000001096351600115 GO_REF:0000107 Ensembl GO_REF:0000107 synaptic vesicle endocytosis IEA UniProtKB:Q9Z0R4 , ensembl:ENSMUSP000001096351600115 GO_REF:0000107 Ensembl GO_REF:0000107 synaptic vesicle endocytosis ISO RGD:1332367 1624291 (MGI:MGI:3811659, PMID:18676989) RGD MGI:MGI:3811659 , PMID:18676989 Cellular Component apical dendrite IDA 13461862 RGD calyx of Held IEA UniProtKB:Q9Z0R4 , ensembl:ENSMUSP000001096351600115 GO_REF:0000107 Ensembl GO_REF:0000107 calyx of Held ISO RGD:1332367 1624291 (MGI:MGI:5492178, PMID:23633571) RGD MGI:MGI:5492178 , PMID:23633571 cell junction IEA UniProtKB-KW:KW-0965 1600115 GO_REF:0000037 UniProt GO_REF:0000037 clathrin-coated pit ISO RGD:737072 1624291 (PMID:20946875) RGD PMID:20946875 clathrin-coated pit colocalizes_with ISO RGD:737072 1624291 (PMID:29887380) RGD PMID:29887380 clathrin-coated pit IDA 13461864 RGD cytoplasm ISO RGD:737072 1624291 (PMID:29599122) RGD PMID:29599122 cytoplasm ISS UniProtKB:Q15811-2 1600115 GO_REF:0000024 UniProt GO_REF:0000024 dendritic spine IDA 13461864 RGD endocytic vesicle ISO RGD:1332367 1624291 (MGI:MGI:3768571, PMID:17875942) RGD MGI:MGI:3768571 , PMID:17875942 endocytic vesicle IEA UniProtKB:Q9Z0R4 , ensembl:ENSMUSP000001096351600115 GO_REF:0000107 Ensembl GO_REF:0000107 glutamatergic synapse IDA 13461864 PMID:19258322 SynGO glutamatergic synapse IMP 13461864 PMID:19258322 SynGO intracellular vesicle IDA 13461862 RGD lamellipodium ISO RGD:1332367 1624291 (MGI:MGI:2158954, PMID:11744688) RGD MGI:MGI:2158954 , PMID:11744688 lamellipodium IEA UniProtKB-SubCell:SL-0291 1600115 GO_REF:0000039 UniProt GO_REF:0000039 neuronal cell body IDA 13461862 RGD nuclear envelope ISO RGD:737072 1624291 (PMID:29599122) RGD PMID:29599122 nuclear envelope ISS UniProtKB:Q15811-2 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nuclear envelope IEA UniProtKB-SubCell:SL-0178 1600115 GO_REF:0000039 UniProt GO_REF:0000039 plasma membrane IDA 13461861 RGD plasma membrane ISO RGD:737072 1624291 (PMID:20946875) RGD PMID:20946875 postsynaptic actin cytoskeleton IDA 13461864 PMID:19258322 SynGO presynaptic endocytic zone IEA UniProtKB:Q9Z0R4 , ensembl:ENSMUSP000001096351600115 GO_REF:0000107 Ensembl GO_REF:0000107 presynaptic endocytic zone ISO RGD:1332367 1624291 (MGI:MGI:5492178, PMID:23633571) RGD MGI:MGI:5492178 , PMID:23633571 recycling endosome IEA UniProtKB-SubCell:SL-0232 1600115 GO_REF:0000039 UniProt GO_REF:0000039 synapse IDA 69862 RGD terminal bouton HDA 10047219 PMID:24876496 ParkinsonsUK-UCL Molecular Function calcium ion binding IEA InterPro:IPR002048 1600115 GO_REF:0000002 InterPro GO_REF:0000002 guanyl-nucleotide exchange factor activity IEA InterPro:IPR000219 , InterPro:IPR001331 1600115 GO_REF:0000002 InterPro GO_REF:0000002 kinase activator activity ISO RGD:1332367 1624291 (MGI:MGI:3768571, PMID:17875942) RGD MGI:MGI:3768571 , PMID:17875942 kinase activator activity IEA UniProtKB:Q9Z0R4 , ensembl:ENSMUSP000001096351600115 GO_REF:0000107 Ensembl GO_REF:0000107 molecular adaptor activity IEA UniProtKB:Q15811 , ensembl:ENSP000003707191600115 GO_REF:0000107 Ensembl GO_REF:0000107 molecular adaptor activity ISO RGD:737072 1624291 (PMID:20946875) RGD PMID:20946875 proline-rich region binding ISO RGD:737072 1624291 UniProtKB:Q9BQI5 (PMID:20946875) RGD PMID:20946875 proline-rich region binding IEA UniProtKB:Q15811 , ensembl:ENSP000003707191600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding IPI RGD:3728 more ... 69862 RGD protein binding ISO RGD:737072 1624291 UniProtKB:O15357 more ... RGD PMID:10064583 more ... protein binding ISO RGD:737072 1624291 UniProtKB:O15357 more ... RGD PMID:10064583 more ... protein binding ISO RGD:1332367 1624291 UniProtKB:A2RSK1 more ... RGD MGI:MGI:2158954 more ... Rho guanyl-nucleotide exchange factor activity IEA InterPro:IPR000219 1600115 GO_REF:0000002 InterPro GO_REF:0000002
Gene-Chemical Interaction Annotations
