Itsn1 (intersectin 1) - Rat Genome Database

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Gene: Itsn1 (intersectin 1) Rattus norvegicus
Analyze
Symbol: Itsn1
Name: intersectin 1
RGD ID: 2935
Description: Predicted to enable kinase activator activity; molecular adaptor activity; and proline-rich region binding activity. Involved in several processes, including positive regulation of dendritic spine development; positive regulation of transport; and regulation of synapse organization. Located in several cellular components, including clathrin-coated pit; dendrite; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Orthologous to human ITSN1 (intersectin 1); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EH domain and SH3 domain regulator of endocytosis 1; EHSH1; intersectin (SH3 domain protein 1A); intersectin 1 (SH3 domain protein 1A); intersectin 1 (SH3 domain protein); intersectin-1; intersectin-1-like; intersection (SH3 domain protein 1A); Itsn; LOC100911851
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21130,978,590 - 31,160,645 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,978,590 - 31,160,645 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1139,672,533 - 39,854,583 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01132,343,963 - 32,526,016 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01131,506,203 - 31,688,572 (+)NCBIRnor_WKY
Rnor_6.01131,943,119 - 32,069,249 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,893,489 - 32,069,249 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01135,547,331 - 35,672,959 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41131,721,528 - 31,901,963 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11131,815,217 - 31,903,071 (+)NCBI
Celera1130,687,099 - 30,812,424 (+)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clothianidin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
Diacetoxyscirpenol  (ISO)
dibutyl phthalate  (ISO)
ethanol  (ISO)
fipronil  (EXP)
formaldehyde  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
hydralazine  (ISO)
ivermectin  (ISO)
lidocaine  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
paracetamol  (EXP)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Neuronal distribution of EHSH1/intersectin: molecular linker between clathrin-mediated endocytosis and signaling pathways. Ma YJ, etal., J Neurosci Res. 2003 Feb 15;71(4):468-77. doi: 10.1002/jnr.10500.
4. Intersectin-1L nucleotide exchange factor regulates secretory granule exocytosis by activating Cdc42. Malacombe M, etal., EMBO J. 2006 Aug 9;25(15):3494-503. doi: 10.1038/sj.emboj.7601247. Epub 2006 Jul 27.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? Okamoto M, etal., J Biol Chem 1999 Jun 25;274(26):18446-54.
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. Intersectin regulates dendritic spine development and somatodendritic endocytosis but not synaptic vesicle recycling in hippocampal neurons. Thomas S, etal., J Biol Chem. 2009 May 1;284(18):12410-9. doi: 10.1074/jbc.M809746200. Epub 2009 Mar 3.
14. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
Additional References at PubMed
PMID:11584276   PMID:11744688   PMID:16394100   PMID:16903783   PMID:17875942   PMID:18676989   PMID:20448150   PMID:20946875   PMID:21088884   PMID:23633571   PMID:25783631   PMID:26437238  
PMID:29476059   PMID:29599122   PMID:29887380  


Genomics

Comparative Map Data
Itsn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21130,978,590 - 31,160,645 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,978,590 - 31,160,645 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1139,672,533 - 39,854,583 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01132,343,963 - 32,526,016 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01131,506,203 - 31,688,572 (+)NCBIRnor_WKY
Rnor_6.01131,943,119 - 32,069,249 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,893,489 - 32,069,249 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01135,547,331 - 35,672,959 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41131,721,528 - 31,901,963 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11131,815,217 - 31,903,071 (+)NCBI
Celera1130,687,099 - 30,812,424 (+)NCBICelera
Cytogenetic Map11q11NCBI
ITSN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382133,642,501 - 33,899,861 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2133,642,400 - 33,899,861 (+)EnsemblGRCh38hg38GRCh38
GRCh372135,014,807 - 35,272,165 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362133,936,654 - 34,183,479 (+)NCBINCBI36Build 36hg18NCBI36
Build 342133,936,653 - 34,183,479NCBI
Celera2120,214,405 - 20,461,193 (+)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2120,493,109 - 20,739,668 (+)NCBIHuRef
CHM1_12134,577,248 - 34,824,084 (+)NCBICHM1_1
T2T-CHM13v2.02132,024,315 - 32,281,564 (+)NCBIT2T-CHM13v2.0
Itsn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391691,526,198 - 91,717,479 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1691,526,169 - 91,717,485 (+)EnsemblGRCm39 Ensembl
GRCm381691,729,310 - 91,920,591 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1691,729,281 - 91,920,597 (+)EnsemblGRCm38mm10GRCm38
MGSCv371691,729,616 - 91,920,824 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361691,671,052 - 91,800,868 (+)NCBIMGSCv36mm8
Celera1692,808,009 - 93,004,876 (+)NCBICelera
Cytogenetic Map16C4NCBI
Itsn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540733,113,319 - 33,275,675 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540733,056,004 - 33,275,681 (+)NCBIChiLan1.0ChiLan1.0
ITSN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12133,381,640 - 33,625,603 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2133,457,081 - 33,625,248 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02120,009,385 - 20,266,835 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ITSN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13129,144,754 - 29,360,134 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3128,243,620 - 28,459,926 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03128,451,006 - 28,667,391 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3128,451,116 - 28,661,479 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13128,317,804 - 28,534,014 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03128,331,715 - 28,548,460 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03128,831,446 - 29,047,794 (+)NCBIUU_Cfam_GSD_1.0
Itsn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497128,789,742 - 28,977,174 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365008,468,940 - 8,612,942 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365008,490,514 - 8,678,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITSN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13197,249,061 - 197,481,245 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113197,301,515 - 197,492,537 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213207,205,545 - 207,267,672 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITSN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1258,298,529 - 58,543,297 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl258,301,399 - 58,543,281 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666071805,376 - 1,047,516 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itsn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474521,906,187 - 22,050,822 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474521,847,593 - 22,055,141 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itsn1
1221 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:123
Interacting mature miRNAs:149
Transcripts:ENSRNOT00000042750, ENSRNOT00000047843
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
D11Rat13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,071,112 - 31,071,247 (+)MAPPERmRatBN7.2
Rnor_6.01131,987,001 - 31,987,134NCBIRnor6.0
Rnor_5.01135,591,213 - 35,591,346UniSTSRnor5.0
RGSC_v3.41131,820,214 - 31,820,348RGDRGSC3.4
RGSC_v3.41131,820,215 - 31,820,348UniSTSRGSC3.4
RGSC_v3.11131,859,087 - 31,859,220RGD
Celera1130,730,986 - 30,731,119UniSTS
RH 3.4 Map11202.3UniSTS
RH 3.4 Map11202.3RGD
FHH x ACI Map1112.19UniSTS
FHH x ACI Map1112.19RGD
Cytogenetic Map11q11UniSTS
D11Got26  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01135,640,985 - 35,641,186NCBIRnor5.0
Rnor_5.01135,640,986 - 35,641,186NCBIRnor5.0
RGSC_v3.41131,869,988 - 31,870,188RGDRGSC3.4
RGSC_v3.41131,869,989 - 31,870,188UniSTSRGSC3.4
RGSC_v3.11131,908,865 - 31,909,064RGD
Celera1130,779,811 - 30,780,014UniSTS
RH 3.4 Map11203.1RGD
RH 3.4 Map11203.1UniSTS
RH 2.0 Map11453.4RGD
Cytogenetic Map11q11UniSTS
RH140585  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,070,630 - 31,070,819 (+)MAPPERmRatBN7.2
Rnor_6.01131,986,519 - 31,986,707NCBIRnor6.0
Rnor_5.01135,590,731 - 35,590,919UniSTSRnor5.0
RGSC_v3.41131,819,733 - 31,819,921UniSTSRGSC3.4
Celera1130,730,504 - 30,730,692UniSTS
RH 3.4 Map11176.8UniSTS
Cytogenetic Map11q11UniSTS
BI283741  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,096,782 - 31,096,948 (+)MAPPERmRatBN7.2
Rnor_6.01132,013,163 - 32,013,328NCBIRnor6.0
Rnor_5.01135,616,875 - 35,617,040UniSTSRnor5.0
RGSC_v3.41131,845,877 - 31,846,042UniSTSRGSC3.4
Celera1130,756,527 - 30,756,692UniSTS
RH 3.4 Map11198.1UniSTS
Cytogenetic Map11q11UniSTS
RH135361  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,001,225 - 31,001,456 (+)MAPPERmRatBN7.2
Rnor_6.01131,917,115 - 31,917,345NCBIRnor6.0
Rnor_5.01135,521,327 - 35,521,557UniSTSRnor5.0
RGSC_v3.41131,750,342 - 31,750,572UniSTSRGSC3.4
Celera1130,661,081 - 30,661,311UniSTS
RH 3.4 Map11200.5UniSTS
Cytogenetic Map11q11UniSTS
REN86881  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,114,822 - 31,115,068 (+)MAPPERmRatBN7.2
Rnor_6.01127,576,301 - 27,576,546NCBIRnor6.0
Rnor_6.01132,031,204 - 32,031,449NCBIRnor6.0
Rnor_5.01135,634,916 - 35,635,161UniSTSRnor5.0
Rnor_5.01131,196,421 - 31,196,666UniSTSRnor5.0
RGSC_v3.41131,863,918 - 31,864,163UniSTSRGSC3.4
Cytogenetic Map11q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26 34 27 11 27 5 8 74 23 33 11 5
Low 3 17 23 14 8 14 3 3 12 8 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000042750   ⟹   ENSRNOP00000044773
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1130,978,590 - 31,116,225 (+)Ensembl
Rnor_6.0 Ensembl1131,893,489 - 32,069,249 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000047843   ⟹   ENSRNOP00000045513
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,027,230 - 31,115,100 (+)Ensembl
Rnor_6.0 Ensembl1131,943,119 - 32,031,481 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085965
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1127,568,537 - 27,577,691 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087733
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1127,566,879 - 27,577,691 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089993
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1127,571,533 - 27,577,691 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096706   ⟹   ENSRNOP00000097531
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1130,978,590 - 31,160,645 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096792   ⟹   ENSRNOP00000095645
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1130,978,590 - 31,160,645 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110949   ⟹   ENSRNOP00000089593
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,146,593 - 31,160,645 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114620   ⟹   ENSRNOP00000077439
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,028,827 - 31,160,645 (+)Ensembl
RefSeq Acc Id: NM_001136096   ⟹   NP_001129568
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21130,978,590 - 31,160,645 (+)NCBI
Rnor_6.01131,943,121 - 32,069,249 (+)NCBI
Rnor_5.01135,547,331 - 35,672,959 (+)NCBI
RGSC_v3.41131,721,528 - 31,901,963 (+)RGD
Celera1130,687,101 - 30,812,424 (+)NCBI
Sequence:
RefSeq Acc Id: NM_019227   ⟹   NP_062100
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21130,978,590 - 31,116,225 (+)NCBI
Rnor_6.01131,943,119 - 32,031,481 (+)NCBI
Rnor_5.01135,547,331 - 35,672,959 (+)NCBI
RGSC_v3.41131,721,528 - 31,901,963 (+)RGD
Celera1130,687,099 - 30,792,058 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088246   ⟹   XP_038944174
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21130,978,689 - 31,153,195 (+)NCBI
RefSeq Acc Id: XM_039088247   ⟹   XP_038944175
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21130,979,480 - 31,154,490 (+)NCBI
RefSeq Acc Id: XM_039088248   ⟹   XP_038944176
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21130,978,689 - 31,097,115 (+)NCBI
RefSeq Acc Id: XM_039088249   ⟹   XP_038944177
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21130,978,689 - 31,097,115 (+)NCBI
RefSeq Acc Id: XM_039088250   ⟹   XP_038944178
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21130,978,689 - 31,102,947 (+)NCBI
RefSeq Acc Id: XM_039088251   ⟹   XP_038944179
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21130,978,689 - 31,088,160 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001129568   ⟸   NM_001136096
- Peptide Label: isoform a
- UniProtKB: Q9WVE1 (UniProtKB/Swiss-Prot),   D3ZV52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_062100   ⟸   NM_019227
- Peptide Label: isoform b
- Sequence:
RefSeq Acc Id: ENSRNOP00000045513   ⟸   ENSRNOT00000047843
RefSeq Acc Id: ENSRNOP00000044773   ⟸   ENSRNOT00000042750
RefSeq Acc Id: XP_038944174   ⟸   XM_039088246
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARZ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944178   ⟸   XM_039088250
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038944176   ⟸   XM_039088248
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038944177   ⟸   XM_039088249
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038944179   ⟸   XM_039088251
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038944175   ⟸   XM_039088247
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARZ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077439   ⟸   ENSRNOT00000114620
RefSeq Acc Id: ENSRNOP00000089593   ⟸   ENSRNOT00000110949
RefSeq Acc Id: ENSRNOP00000097531   ⟸   ENSRNOT00000096706
RefSeq Acc Id: ENSRNOP00000095645   ⟸   ENSRNOT00000096792
Protein Domains
C2   DH   EF-hand   EH   PH   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVE9-F1-model_v2 AlphaFold Q9WVE9 1-1713 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2935 AgrOrtholog
BIND 130893
BioCyc Gene G2FUF-21874 BioCyc
Ensembl Genes ENSRNOG00000002001 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000061155 Ensembl
Ensembl Protein ENSRNOP00000044773 ENTREZGENE
  ENSRNOP00000044773.6 UniProtKB/TrEMBL
  ENSRNOP00000045513.6 UniProtKB/TrEMBL
  ENSRNOP00000077439.1 UniProtKB/TrEMBL
  ENSRNOP00000089593.1 UniProtKB/TrEMBL
  ENSRNOP00000095645 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000097531 ENTREZGENE
  ENSRNOP00000097531.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042750 ENTREZGENE
  ENSRNOT00000042750.6 UniProtKB/TrEMBL
  ENSRNOT00000047843.7 UniProtKB/TrEMBL
  ENSRNOT00000096706 ENTREZGENE
  ENSRNOT00000096706.1 UniProtKB/TrEMBL
  ENSRNOT00000096792 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000110949.1 UniProtKB/TrEMBL
  ENSRNOT00000114620.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29491 UniProtKB/Swiss-Prot
NCBI Gene 29491 ENTREZGENE
Pfam EF-hand_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Itsn1 PhenoGen
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC220013
UniProt A0A8I5Y9J0_RAT UniProtKB/TrEMBL
  A0A8I6A7M7_RAT UniProtKB/TrEMBL
  A0A8I6ARZ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QLK0_RAT UniProtKB/TrEMBL
  A0A8L2QM65_RAT UniProtKB/TrEMBL
  D3ZV52 ENTREZGENE
  ITSN1_RAT UniProtKB/Swiss-Prot
  Q9WVE1 ENTREZGENE
  Q9WVE9 ENTREZGENE
UniProt Secondary D3ZV52 UniProtKB/Swiss-Prot
  F1M823 UniProtKB/Swiss-Prot
  Q9WVE1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Itsn1  intersectin 1  LOC100911851  intersectin-1-like  Data Merged 737654 PROVISIONAL
2015-11-19 Itsn1  intersectin 1  Itsn1  intersectin 1 (SH3 domain protein)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911851  intersectin-1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-11-17 Itsn1  intersectin 1 (SH3 domain protein)  Itsn1  intersectin 1 (SH3 domain protein 1A)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-19 Itsn1  intersectin 1 (SH3 domain protein 1A)  Itsn1  intersectin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Itsn1  intersectin 1  Itsn    Symbol updated 1299863 APPROVED
2002-06-10 Itsn  intersectin 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains has two EH domains,a central KLERQ domain and five SH3 domains 69862
gene_expression expressed abundantly in the brain 69862
gene_function an adaptor protein which participates in ther coupling of endocytic membrane traffic to exocytosis 69862