Gene: Dnm1l (dynamin 1-like) Rattus norvegicus
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Symbol: Dnm1l
Name: dynamin 1-like
Description: Exhibits BH2 domain binding activity and clathrin binding activity. Involved in several processes, including cellular response to oxygen-glucose deprivation; positive regulation of cellular component organization; and synaptic vesicle recycling. Localizes to the cytoplasm and presynaptic endocytic zone membrane. Colocalizes with the clathrin-coated pit and mitochondrial membrane. Biomarker of chronic kidney disease; dental fluorosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in brain disease and optic atrophy. Orthologous to human DNM1L (dynamin 1 like); PARTICIPATES IN mitochondria fission pathway; endocytosis pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C-terminal region; DLP1; Dnml1; Drp1; dynamin-1-like protein; dynamin-like protein 1; dynamin-related protein 1; N-terminal region
Orthologs:
Homo sapiens (human) : DNM1L (dynamin 1 like)  HGNC  Alliance
Mus musculus (house mouse) : Dnm1l (dynamin 1-like)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnm1l (dynamin 1 like)
Pan paniscus (bonobo/pygmy chimpanzee) : DNM1L (dynamin 1 like)
Canis lupus familiaris (dog) : DNM1L (dynamin 1 like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnm1l (dynamin 1 like)
Sus scrofa (pig) : DNM1L (dynamin 1 like)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01188,830,968 - 88,882,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01191,885,295 - 91,936,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,617,236 - 86,665,861 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,657,172 - 86,706,365 (-)NCBI
Celera1183,326,642 - 83,375,373 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Dnm1l
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620416
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-06-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.