Dnm1l (dynamin 1-like) - Rat Genome Database

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Gene: Dnm1l (dynamin 1-like) Rattus norvegicus
Analyze
Symbol: Dnm1l
Name: dynamin 1-like
RGD ID: 620416
Description: Exhibits BH2 domain binding activity; clathrin binding activity; and identical protein binding activity. Involved in several processes, including mitochondrion organization; positive regulation of cellular component organization; and synaptic vesicle recycling. Localizes to several cellular components, including bounding membrane of organelle; perinuclear region of cytoplasm; and presynaptic endocytic zone membrane. Colocalizes with clathrin-coated pit and mitochondrial membrane. Biomarker of chronic kidney disease; dental fluorosis; pulmonary fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Orthologous to human DNM1L (dynamin 1 like); PARTICIPATES IN mitochondria fission pathway; endocytosis pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C-terminal region; DLP1; Dnml1; Drp1; dynamin-1-like protein; dynamin-like protein 1; dynamin-related protein 1; N-terminal region
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21184,581,216 - 84,632,382 (+)NCBI
Rnor_6.0 Ensembl1188,830,957 - 88,880,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01188,830,968 - 88,882,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01191,885,295 - 91,936,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,617,236 - 86,665,861 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,657,172 - 86,706,365 (-)NCBI
Celera1183,326,642 - 83,375,373 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-DAMP(1+)  (EXP)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alpha-D-galactose  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (EXP,ISO)
azide  (EXP,ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
CCCP  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dicrotophos  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
excitatory amino acid agonist  (EXP)
fenvalerate  (EXP)
ferric ammonium citrate  (ISO)
ferulic acid  (EXP)
galactose  (EXP,ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
Genipin  (ISO)
glucose  (EXP,ISO)
glycidol  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
Licarin A  (ISO)
mabuterol  (EXP)
mangiferin  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
metformin  (EXP)
methoxychlor  (ISO)
N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nicotine  (ISO)
nitrogen dioxide  (ISO)
okadaic acid  (EXP)
oxidopamine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
pyrroloquinoline quinone  (EXP,ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
Salvianolic acid A  (EXP,ISO)
SB-239063  (EXP)
sevoflurane  (EXP)
silicon dioxide  (EXP)
simvastatin  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (EXP)
streptozocin  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thymoquinone  (EXP)
trans-cinnamic acid  (EXP)
trifloxystrobin  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zidovudine  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion transport  (ISO)
cellular response to lipid  (IEP)
cellular response to oxygen-glucose deprivation  (IEP)
cellular response to thapsigargin  (IMP)
dynamin family protein polymerization involved in mitochondrial fission  (IBA,ISO,ISS)
endoplasmic reticulum organization  (ISO)
heart contraction  (ISO)
intracellular distribution of mitochondria  (IBA,IMP,ISO)
membrane fusion  (IBA,ISO)
mitochondrial fission  (IBA,ISO,ISS)
mitochondrial fragmentation involved in apoptotic process  (IBA,IMP,ISO)
mitochondrial membrane fission  (ISO)
mitochondrion morphogenesis  (IMP)
mitochondrion organization  (ISO)
necroptotic process  (ISO,ISS)
negative regulation of mitochondrial fusion  (IMP)
peroxisome fission  (ISO,ISS)
positive regulation of apoptotic process  (ISO)
positive regulation of dendritic spine morphogenesis  (IMP)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of mitochondrial fission  (IMP,ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of synaptic vesicle endocytosis  (IMP)
positive regulation of synaptic vesicle exocytosis  (IMP)
protein complex oligomerization  (ISO,ISS)
protein localization to mitochondrion  (ISO)
protein-containing complex assembly  (ISO)
regulation of ATP metabolic process  (ISO)
regulation of autophagy of mitochondrion  (IBA,ISO)
regulation of gene expression  (ISO)
regulation of mitochondrion organization  (ISO)
regulation of peroxisome organization  (ISO)
regulation of ubiquitin protein ligase activity  (ISO)
release of cytochrome c from mitochondria  (ISO)
response to flavonoid  (IEP)
response to hypobaric hypoxia  (IEP)
rhythmic process  (IEA)
synaptic vesicle endocytosis  (IDA,IMP)
synaptic vesicle recycling via endosome  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Aparicio-Trejo OE, etal., Biofactors. 2016 Nov 1. doi: 10.1002/biof.1338.
2. Chitra L and Boopathy R, Br J Pharmacol. 2013 Jul;169(5):1035-47. doi: 10.1111/bph.12179.
3. da Silva AF, etal., Cell Mol Life Sci. 2014 Jun;71(12):2313-24. doi: 10.1007/s00018-014-1557-8. Epub 2014 Jan 18.
4. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. GOA data from the GO Consortium
6. Hom JR, etal., J Cell Physiol. 2007 Aug;212(2):498-508.
7. Koch A, etal., J Biol Chem 2003 Mar 7;278(10):8597-605. Epub 2002 Dec 23.
8. Li H, etal., Nat Cell Biol. 2013 Jul;15(7):773-85. doi: 10.1038/ncb2791. Epub 2013 Jun 23.
9. Li H, etal., Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2169-74. doi: 10.1073/pnas.0711647105. Epub 2008 Feb 4.
10. Li X and Gould SJ, J Biol Chem 2003 May 9;278(19):17012-20.
11. Lou DD, etal., Arch Toxicol. 2013 Mar;87(3):449-57. doi: 10.1007/s00204-012-0942-z. Epub 2012 Sep 25.
12. Mao C, etal., J Cell Mol Med. 2014 Dec;18(12):2404-16. doi: 10.1111/jcmm.12420. Epub 2014 Oct 6.
13. MGD Curation, June 12, 2002
14. MGD data from the GO Consortium
15. NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline
17. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
18. Parra V, etal., Cardiovasc Res. 2008 Jan 15;77(2):387-97. Epub 2007 Oct 4.
19. Pipeline to import KEGG annotations from KEGG into RGD
20. Pitts KR, etal., Mol Biol Cell 1999 Dec;10(12):4403-17.
21. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. RGD automated import pipeline for gene-chemical interactions
23. Wang X, etal., J Neurosci. 2009 Jul 15;29(28):9090-103. doi: 10.1523/JNEUROSCI.1357-09.2009.
24. Wappler EA, etal., PLoS One. 2013 May 2;8(5):e63206. doi: 10.1371/journal.pone.0063206. Print 2013.
25. Yan J, etal., J Nutr Biochem. 2012 Jul;23(7):716-24. doi: 10.1016/j.jnutbio.2011.03.014. Epub 2011 Aug 4.
26. Yoon Y, etal., J Cell Biol. 1998 Feb 23;140(4):779-93.
27. Zou D, etal., Med Sci Sports Exerc. 2014 Nov;46(11):2077-84. doi: 10.1249/MSS.0000000000000336.
Additional References at PubMed
PMID:9570752   PMID:10679301   PMID:11514614   PMID:11553726   PMID:12477932   PMID:12499352   PMID:12861026   PMID:15489334   PMID:16874301   PMID:17301055   PMID:17408615   PMID:18353969  
PMID:19074440   PMID:19279012   PMID:19407830   PMID:19946888   PMID:20038678   PMID:20062521   PMID:20585624   PMID:20594982   PMID:20688057   PMID:20850011   PMID:21149567   PMID:21525035  
PMID:21537829   PMID:21700703   PMID:21701560   PMID:21813700   PMID:21890690   PMID:22114352   PMID:22229526   PMID:22265414   PMID:22334657   PMID:22493254   PMID:22511751   PMID:22732450  
PMID:22871113   PMID:23166623   PMID:23283981   PMID:23349293   PMID:23486469   PMID:23530233   PMID:23530241   PMID:23584531   PMID:23628672   PMID:23764851   PMID:23772688   PMID:23798729  
PMID:23882026   PMID:23921378   PMID:24081164   PMID:24477044   PMID:24515348   PMID:24561342   PMID:24599962   PMID:24632637   PMID:25012575   PMID:25018043   PMID:25399916   PMID:25732239  
PMID:25767741   PMID:25791474   PMID:25853493   PMID:26122121   PMID:26196303   PMID:26219591   PMID:26418124   PMID:26618722   PMID:26732476   PMID:26992161   PMID:27010815   PMID:27145208  
PMID:27159033   PMID:27175924   PMID:27252377   PMID:27301544   PMID:27328748   PMID:27794519   PMID:28063983   PMID:28265681   PMID:28273447   PMID:28347692   PMID:28388446   PMID:28411026  
PMID:28463107   PMID:28579326   PMID:28969390   PMID:29307555   PMID:29336470   PMID:29435096   PMID:29476059   PMID:29573704   PMID:29604406   PMID:29704468   PMID:29864925   PMID:29899447  
PMID:29953931   PMID:29981304   PMID:30053369   PMID:30059978   PMID:30148677   PMID:30158524   PMID:30317624   PMID:30439527   PMID:30689811   PMID:30914652   PMID:31152817   PMID:31239323  
PMID:31914641   PMID:31949126   PMID:31990365   PMID:32108342   PMID:32312970   PMID:32845721  


Genomics

Comparative Map Data
Dnm1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21184,581,216 - 84,632,382 (+)NCBI
Rnor_6.0 Ensembl1188,830,957 - 88,880,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01188,830,968 - 88,882,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01191,885,295 - 91,936,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,617,236 - 86,665,861 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,657,172 - 86,706,365 (-)NCBI
Celera1183,326,642 - 83,375,373 (+)NCBICelera
Cytogenetic Map11q23NCBI
DNM1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1232,679,200 - 32,745,650 (+)EnsemblGRCh38hg38GRCh38
GRCh381232,679,296 - 32,745,650 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371232,832,235 - 32,898,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361232,723,491 - 32,788,621 (+)NCBINCBI36hg18NCBI36
Build 341232,723,490 - 32,787,810NCBI
Celera1212,653,086 - 12,719,281 (+)NCBI
Cytogenetic Map12p11.21NCBI
HuRef1232,584,423 - 32,651,060 (+)NCBIHuRef
CHM1_11232,798,646 - 32,865,086 (+)NCBICHM1_1
Dnm1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,130,092 - 16,176,902 (-)NCBIGRCm39mm39
GRCm39 Ensembl1616,130,094 - 16,176,823 (-)Ensembl
GRCm381616,312,228 - 16,359,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,312,230 - 16,358,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv371616,312,326 - 16,359,123 (-)NCBIGRCm37mm9NCBIm37
MGSCv361616,225,811 - 16,272,608 (-)NCBImm8
Celera1616,883,274 - 16,930,064 (-)NCBICelera
Cytogenetic Map16A2NCBI
Dnm1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555053,023,018 - 3,081,680 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555053,025,742 - 3,081,491 (-)NCBIChiLan1.0ChiLan1.0
DNM1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11256,077,504 - 56,142,376 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1256,077,504 - 56,142,376 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01253,476,553 - 53,541,421 (-)NCBIMhudiblu_PPA_v0panPan3
DNM1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12716,161,855 - 16,211,983 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2716,163,357 - 16,211,957 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2730,213,206 - 30,264,757 (+)NCBI
ROS_Cfam_1.02716,342,630 - 16,394,291 (-)NCBI
UMICH_Zoey_3.12716,151,140 - 16,202,287 (-)NCBI
UNSW_CanFamBas_1.02716,183,766 - 16,235,121 (-)NCBI
UU_Cfam_GSD_1.02730,361,257 - 30,412,627 (+)NCBI
Dnm1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494576,743,024 - 76,799,054 (-)NCBI
SpeTri2.0NW_0049366073,576,357 - 3,632,423 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNM1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1541,571,054 - 41,636,058 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2544,756,967 - 44,785,760 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNM1L
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11132,114,642 - 32,178,330 (+)NCBI
ChlSab1.1 Ensembl1132,114,675 - 32,177,661 (+)Ensembl
Vero_WHO_p1.0NW_0236660692,716,938 - 2,783,519 (-)NCBI
Dnm1l
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247783,391,690 - 3,475,548 (-)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115785881090463843Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115994302390463843Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116449467190463843Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116964970890463843Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1089
Count of miRNA genes:194
Interacting mature miRNAs:236
Transcripts:ENSRNOT00000002477, ENSRNOT00000002478, ENSRNOT00000002479, ENSRNOT00000002482, ENSRNOT00000002485
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 54 38 19 38 8 10 74 35 41 11 8
Low 1 3 3 3 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF019043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF020207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF020208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF020209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF020210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF020211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF020212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF020213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF107048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF132727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000002477   ⟹   ENSRNOP00000002477
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1188,830,968 - 88,880,177 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000002478   ⟹   ENSRNOP00000002478
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1188,831,130 - 88,879,997 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000002482   ⟹   ENSRNOP00000002482
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1188,830,957 - 88,880,198 (+)Ensembl
RefSeq Acc Id: NM_053655   ⟹   NP_446107
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,581,216 - 84,629,913 (+)NCBI
Rnor_6.01188,830,968 - 88,880,178 (+)NCBI
Rnor_5.01191,885,295 - 91,936,512 (+)NCBI
RGSC_v3.41186,617,236 - 86,665,861 (-)RGD
Celera1183,326,642 - 83,375,373 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248715   ⟹   XP_006248777
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,830,973 - 88,882,271 (+)NCBI
Rnor_5.01191,885,295 - 91,936,512 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248722   ⟹   XP_006248784
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,830,974 - 88,882,271 (+)NCBI
Rnor_5.01191,885,295 - 91,936,512 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248723   ⟹   XP_006248785
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,830,974 - 88,882,271 (+)NCBI
Rnor_5.01191,885,295 - 91,936,512 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248724   ⟹   XP_006248786
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,830,974 - 88,882,271 (+)NCBI
Rnor_5.01191,885,295 - 91,936,512 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768840   ⟹   XP_008767062
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,830,973 - 88,882,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768841   ⟹   XP_008767063
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,830,973 - 88,882,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768842   ⟹   XP_008767064
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,830,973 - 88,882,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768843   ⟹   XP_008767065
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,830,973 - 88,882,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768844   ⟹   XP_008767066
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,830,974 - 88,882,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768845   ⟹   XP_008767067
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,830,973 - 88,882,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768846   ⟹   XP_008767068
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,830,974 - 88,882,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768847   ⟹   XP_008767069
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,830,974 - 88,882,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597843   ⟹   XP_017453332
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,830,973 - 88,882,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597844   ⟹   XP_017453333
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,831,260 - 88,882,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039087888   ⟹   XP_038943816
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,581,219 - 84,632,382 (+)NCBI
RefSeq Acc Id: XM_039087889   ⟹   XP_038943817
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,581,219 - 84,632,382 (+)NCBI
RefSeq Acc Id: XM_039087890   ⟹   XP_038943818
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,581,219 - 84,632,382 (+)NCBI
RefSeq Acc Id: XM_039087891   ⟹   XP_038943819
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,581,219 - 84,632,382 (+)NCBI
RefSeq Acc Id: XM_039087892   ⟹   XP_038943820
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,581,220 - 84,632,382 (+)NCBI
RefSeq Acc Id: XM_039087893   ⟹   XP_038943821
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,581,220 - 84,632,382 (+)NCBI
RefSeq Acc Id: XM_039087894   ⟹   XP_038943822
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,581,220 - 84,632,382 (+)NCBI
RefSeq Acc Id: XM_039087895   ⟹   XP_038943823
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,581,220 - 84,632,382 (+)NCBI
RefSeq Acc Id: XM_039087896   ⟹   XP_038943824
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,581,220 - 84,632,382 (+)NCBI
RefSeq Acc Id: XM_039087897   ⟹   XP_038943825
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,581,220 - 84,632,382 (+)NCBI
RefSeq Acc Id: XM_039087898   ⟹   XP_038943826
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,581,220 - 84,632,382 (+)NCBI
RefSeq Acc Id: XM_039087899   ⟹   XP_038943827
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,581,220 - 84,632,382 (+)NCBI
RefSeq Acc Id: XM_039087900   ⟹   XP_038943828
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,581,220 - 84,632,382 (+)NCBI
RefSeq Acc Id: XM_039087901   ⟹   XP_038943829
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21184,581,602 - 84,632,382 (+)NCBI
Protein Sequences
Protein RefSeqs NP_446107 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943816 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943817 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943818 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943819 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943820 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943821 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943822 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943823 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943824 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943825 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943826 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943827 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943828 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943829 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB71232 (Get FASTA)   NCBI Sequence Viewer  
  AAB71233 (Get FASTA)   NCBI Sequence Viewer  
  AAB71234 (Get FASTA)   NCBI Sequence Viewer  
  AAB71235 (Get FASTA)   NCBI Sequence Viewer  
  AAB71236 (Get FASTA)   NCBI Sequence Viewer  
  AAB71237 (Get FASTA)   NCBI Sequence Viewer  
  AAB71238 (Get FASTA)   NCBI Sequence Viewer  
  AAB72197 (Get FASTA)   NCBI Sequence Viewer  
  AAD22412 (Get FASTA)   NCBI Sequence Viewer  
  AAD31278 (Get FASTA)   NCBI Sequence Viewer  
  AAH85843 (Get FASTA)   NCBI Sequence Viewer  
  EDL77849 (Get FASTA)   NCBI Sequence Viewer  
  EDL77850 (Get FASTA)   NCBI Sequence Viewer  
  EDL77851 (Get FASTA)   NCBI Sequence Viewer  
  EDL77852 (Get FASTA)   NCBI Sequence Viewer  
  O35303 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446107   ⟸   NM_053655
- UniProtKB: O35303 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006248777   ⟸   XM_006248715
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006248784   ⟸   XM_006248722
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_006248785   ⟸   XM_006248723
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_006248786   ⟸   XM_006248724
- Peptide Label: isoform X13
- Sequence:
RefSeq Acc Id: XP_008767066   ⟸   XM_008768844
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_008767068   ⟸   XM_008768846
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_008767062   ⟸   XM_008768840
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008767064   ⟸   XM_008768842
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008767063   ⟸   XM_008768841
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008767065   ⟸   XM_008768843
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008767067   ⟸   XM_008768845
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_008767069   ⟸   XM_008768847
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_017453332   ⟸   XM_017597843
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017453333   ⟸   XM_017597844
- Peptide Label: isoform X14
- Sequence:
RefSeq Acc Id: ENSRNOP00000002482   ⟸   ENSRNOT00000002482
RefSeq Acc Id: ENSRNOP00000002477   ⟸   ENSRNOT00000002477
RefSeq Acc Id: ENSRNOP00000002478   ⟸   ENSRNOT00000002478
RefSeq Acc Id: XP_038943816   ⟸   XM_039087888
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038943818   ⟸   XM_039087890
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038943819   ⟸   XM_039087891
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038943817   ⟸   XM_039087889
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038943822   ⟸   XM_039087894
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038943825   ⟸   XM_039087897
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038943826   ⟸   XM_039087898
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038943820   ⟸   XM_039087892
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038943824   ⟸   XM_039087896
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038943827   ⟸   XM_039087899
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038943821   ⟸   XM_039087893
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038943823   ⟸   XM_039087895
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038943828   ⟸   XM_039087900
- Peptide Label: isoform X13
RefSeq Acc Id: XP_038943829   ⟸   XM_039087901
- Peptide Label: isoform X14
Protein Domains
Dynamin-type G   GED

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698343
Promoter ID:EPDNEW_R8868
Type:initiation region
Name:Dnm1l_1
Description:dynamin 1-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01188,830,996 - 88,831,056EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620416 AgrOrtholog
Ensembl Genes ENSRNOG00000001813 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000002477 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000002478 UniProtKB/Swiss-Prot
  ENSRNOP00000002482 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002477 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000002478 UniProtKB/Swiss-Prot
  ENSRNOT00000002482 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
InterPro DNM1L UniProtKB/Swiss-Prot
  Dynamin_central UniProtKB/Swiss-Prot
  Dynamin_GTPase UniProtKB/Swiss-Prot
  Dynamin_GTPase_CS UniProtKB/Swiss-Prot
  Dynamin_SF UniProtKB/Swiss-Prot
  G_DYNAMIN_dom UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
  GED_dom UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:114114 UniProtKB/Swiss-Prot
NCBI Gene 114114 ENTREZGENE
PANTHER PTHR11566 UniProtKB/Swiss-Prot
  PTHR11566:SF39 UniProtKB/Swiss-Prot
Pfam Dynamin_M UniProtKB/Swiss-Prot
  Dynamin_N UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
PhenoGen Dnm1l PhenoGen
PRINTS DYNAMIN UniProtKB/Swiss-Prot
PROSITE G_DYNAMIN_1 UniProtKB/Swiss-Prot
  G_DYNAMIN_2 UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
SMART DYNc UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt DNM1L_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O35318 UniProtKB/Swiss-Prot
  O35319 UniProtKB/Swiss-Prot
  O35320 UniProtKB/Swiss-Prot
  O35321 UniProtKB/Swiss-Prot
  O35322 UniProtKB/Swiss-Prot
  O35323 UniProtKB/Swiss-Prot
  Q5U2W1 UniProtKB/Swiss-Prot
  Q792T7 UniProtKB/Swiss-Prot
  Q9R234 UniProtKB/Swiss-Prot
  Q9R277 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Dnm1l  dynamin 1-like      Symbol and Name updated 629477 APPROVED
2003-03-07 Dnm1l  dynamin 1-like  Dnml1  dynamin 1-like  Data Merged 628472 PROVISIONAL
2002-08-07 Dnm1l  dynamin 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-07-09 Dnml1  dynamin 1-like      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference