Slc51a (solute carrier family 51 subunit alpha) - Rat Genome Database

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Gene: Slc51a (solute carrier family 51 subunit alpha) Rattus norvegicus
Analyze
Symbol: Slc51a
Name: solute carrier family 51 subunit alpha
RGD ID: 1311100
Description: Predicted to enable bile acid transmembrane transporter activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in bile acid and bile salt transport and bile acid secretion. Predicted to act upstream of or within organic substance transport and transmembrane transport. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human SLC51A (solute carrier family 51 subunit alpha); INTERACTS WITH (-)-epigallocatechin 3-gallate; 17alpha-ethynylestradiol; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC303879; organic solute transporter alpha; organic solute transporter subunit alpha; Osta; Ostalpha; RGD1311100; similar to RIKEN cDNA D630035O19; solute carrier family 51, alpha subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21168,299,086 - 68,313,485 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,299,086 - 68,313,485 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,136,126 - 77,150,524 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01169,800,636 - 69,815,078 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01168,825,248 - 68,839,646 (+)NCBIRnor_WKY
Rnor_6.01171,533,078 - 71,547,476 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,533,078 - 71,547,476 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,617,803 - 74,632,201 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,115,430 - 70,129,828 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,173,221 - 70,187,418 (+)NCBI
Celera1167,731,785 - 67,746,102 (+)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
amoxicillin  (ISO)
atazanavir sulfate  (ISO)
Augmentin  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
bromobenzene  (EXP)
budesonide  (EXP,ISO)
buta-1,3-diene  (ISO)
calcitriol  (ISO)
captan  (ISO)
chenodeoxycholic acid  (EXP,ISO)
cholic acid  (ISO)
cisplatin  (ISO)
clavulanic acid  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dioxygen  (ISO)
diuron  (EXP)
epoxiconazole  (ISO)
fenvalerate  (EXP)
fidaxomicin  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folpet  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
imipenem hydrate  (ISO)
leflunomide  (ISO)
lithocholic acid  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
oleanolic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
quinolin-8-ol  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
ritonavir  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
taurochenodeoxycholic acid  (ISO)
taurocholic acid  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Ballatori N, etal., Hepatology. 2005 Dec;42(6):1270-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12719432   PMID:17650074   PMID:22535958  


Genomics

Comparative Map Data
Slc51a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21168,299,086 - 68,313,485 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,299,086 - 68,313,485 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,136,126 - 77,150,524 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01169,800,636 - 69,815,078 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01168,825,248 - 68,839,646 (+)NCBIRnor_WKY
Rnor_6.01171,533,078 - 71,547,476 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,533,078 - 71,547,476 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,617,803 - 74,632,201 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,115,430 - 70,129,828 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,173,221 - 70,187,418 (+)NCBI
Celera1167,731,785 - 67,746,102 (+)NCBICelera
Cytogenetic Map11q22NCBI
SLC51A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383196,216,534 - 196,233,427 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3196,211,487 - 196,243,178 (+)EnsemblGRCh38hg38GRCh38
GRCh373195,943,405 - 195,960,298 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,427,780 - 197,444,698 (+)NCBINCBI36Build 36hg18NCBI36
Celera3194,523,852 - 194,541,937 (+)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3193,243,225 - 193,260,016 (+)NCBIHuRef
CHM1_13195,914,213 - 195,931,131 (+)NCBICHM1_1
T2T-CHM13v2.03198,936,009 - 198,952,903 (+)NCBIT2T-CHM13v2.0
Slc51a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,294,396 - 32,306,697 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,293,322 - 32,306,697 (-)EnsemblGRCm39 Ensembl
GRCm381632,475,578 - 32,487,879 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,474,504 - 32,487,879 (-)EnsemblGRCm38mm10GRCm38
MGSCv371632,475,664 - 32,487,965 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361632,395,325 - 32,407,626 (-)NCBIMGSCv36mm8
Celera1632,959,481 - 32,971,619 (-)NCBICelera
Cytogenetic Map16B3NCBI
Slc51a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,453,554 - 12,463,150 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542012,452,562 - 12,463,369 (+)NCBIChiLan1.0ChiLan1.0
SLC51A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13203,504,092 - 203,521,354 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3203,504,092 - 203,521,354 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03193,554,592 - 193,573,984 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC51A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,336,000 - 29,361,782 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,336,552 - 29,361,738 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3329,359,044 - 29,386,089 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03329,568,832 - 29,595,224 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3329,577,626 - 29,595,172 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13329,355,369 - 29,382,432 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03329,409,253 - 29,436,254 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03330,032,590 - 30,059,010 (+)NCBIUU_Cfam_GSD_1.0
Slc51a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602125,000,914 - 125,019,174 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936784866,350 - 884,355 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936784864,019 - 887,755 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC51A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13133,851,776 - 133,869,753 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113133,851,775 - 133,869,753 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213143,289,639 - 143,307,618 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC51A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11590,953,601 - 90,970,958 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1590,949,639 - 90,970,240 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604164,791,102 - 64,810,753 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc51a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,404,807 - 61,416,384 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473061,405,480 - 61,416,602 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc51a
60 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:116
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000002405
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat

Markers in Region
RH131161  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,313,129 - 68,313,321 (+)MAPPERmRatBN7.2
Rnor_6.01171,547,121 - 71,547,312NCBIRnor6.0
Rnor_5.01174,631,846 - 74,632,037UniSTSRnor5.0
RGSC_v3.41170,129,473 - 70,129,664UniSTSRGSC3.4
Celera1167,745,747 - 67,745,938UniSTS
Cytogenetic Map11q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 1 1 8 2
Low 19 23 8 18 8 8 10 11 21 21 11 8
Below cutoff 22 11 11 11 1 8 4 15

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002405   ⟹   ENSRNOP00000002405
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,299,086 - 68,313,485 (+)Ensembl
Rnor_6.0 Ensembl1171,533,078 - 71,547,476 (+)Ensembl
RefSeq Acc Id: NM_001107087   ⟹   NP_001100557
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21168,299,086 - 68,313,485 (+)NCBI
Rnor_6.01171,533,078 - 71,547,476 (+)NCBI
Rnor_5.01174,617,803 - 74,632,201 (+)NCBI
RGSC_v3.41170,115,430 - 70,129,828 (+)RGD
Celera1167,731,785 - 67,746,102 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100557 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11411 (Get FASTA)   NCBI Sequence Viewer  
  EDM11412 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100557   ⟸   NM_001107087
- UniProtKB: D4AC81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002405   ⟸   ENSRNOT00000002405

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AC81-F1-model_v2 AlphaFold D4AC81 1-340 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698209
Promoter ID:EPDNEW_R8733
Type:initiation region
Name:Slc51a_1
Description:solute carrier family 51, alpha subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01171,533,266 - 71,533,326EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311100 AgrOrtholog
BioCyc Gene G2FUF-21097 BioCyc
Ensembl Genes ENSRNOG00000001765 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002405 ENTREZGENE
  ENSRNOP00000002405.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002405 ENTREZGENE
  ENSRNOT00000002405.6 UniProtKB/TrEMBL
InterPro DUF300 UniProtKB/TrEMBL
KEGG Report rno:303879 UniProtKB/TrEMBL
NCBI Gene 303879 ENTREZGENE
PANTHER DUF300 UniProtKB/TrEMBL
Pfam DUF300 UniProtKB/TrEMBL
PhenoGen Slc51a PhenoGen
UniProt D4AC81 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Slc51a  solute carrier family 51 subunit alpha  Slc51a  solute carrier family 51, alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-05 Slc51a  solute carrier family 51, alpha subunit  Ostalpha  organic solute transporter alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Ostalpha  organic solute transporter alpha  Osta  organic solute transporter alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-27 Osta  organic solute transporter alpha  RGD1311100_predicted  similar to RIKEN cDNA D630035O19 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1311100_predicted  similar to RIKEN cDNA D630035O19 (predicted)  LOC303879_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC303879_predicted  similar to RIKEN cDNA D630035O19 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL