Slc35a5 (solute carrier family 35, member A5) - Rat Genome Database

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Gene: Slc35a5 (solute carrier family 35, member A5) Rattus norvegicus
Analyze
Symbol: Slc35a5
Name: solute carrier family 35, member A5
RGD ID: 1564361
Description: Predicted to enable pyrimidine nucleotide-sugar transmembrane transporter activity. Predicted to be involved in carbohydrate transport and pyrimidine nucleotide-sugar transmembrane transport. Predicted to be active in Golgi membrane. Orthologous to human SLC35A5 (solute carrier family 35 member A5); INTERACTS WITH bisphenol A; gentamycin; paracetamol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC498081; probable UDP-sugar transporter protein SLC35A5; RGD1564361; similar to solute carrier family 35, member A5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21155,653,376 - 55,674,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,653,394 - 55,674,473 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,467,085 - 64,487,376 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01157,128,942 - 57,149,235 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01156,199,381 - 56,219,661 (+)NCBIRnor_WKY
Rnor_6.01160,613,865 - 60,634,849 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1160,613,882 - 60,634,851 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01164,716,008 - 64,737,004 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,190,760 - 57,211,083 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1155,219,430 - 55,239,646 (+)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Slc35a5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21155,653,376 - 55,674,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,653,394 - 55,674,473 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,467,085 - 64,487,376 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01157,128,942 - 57,149,235 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01156,199,381 - 56,219,661 (+)NCBIRnor_WKY
Rnor_6.01160,613,865 - 60,634,849 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1160,613,882 - 60,634,851 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01164,716,008 - 64,737,004 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,190,760 - 57,211,083 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1155,219,430 - 55,239,646 (+)NCBICelera
Cytogenetic Map11q21NCBI
SLC35A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383112,561,320 - 112,585,579 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3112,561,709 - 112,585,579 (+)EnsemblGRCh38hg38GRCh38
GRCh373112,280,167 - 112,304,426 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363113,763,585 - 113,785,693 (+)NCBINCBI36Build 36hg18NCBI36
Build 343113,763,584 - 113,785,692NCBI
Celera3110,689,568 - 110,711,683 (+)NCBICelera
Cytogenetic Map3q13.2NCBI
HuRef3109,664,922 - 109,686,677 (+)NCBIHuRef
CHM1_13112,244,788 - 112,267,218 (+)NCBICHM1_1
T2T-CHM13v2.03115,282,355 - 115,306,614 (+)NCBIT2T-CHM13v2.0
Slc35a5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391644,959,936 - 44,979,036 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1644,959,936 - 44,979,069 (-)EnsemblGRCm39 Ensembl
GRCm381645,139,573 - 45,158,673 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1645,139,573 - 45,158,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv371645,139,686 - 45,158,786 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361645,058,905 - 45,077,971 (-)NCBIMGSCv36mm8
Celera1645,532,900 - 45,552,193 (-)NCBICelera
Cytogenetic Map16B5NCBI
cM Map1629.44NCBI
Slc35a5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542712,906,632 - 12,940,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542712,906,650 - 12,940,419 (+)NCBIChiLan1.0ChiLan1.0
SLC35A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13116,634,496 - 116,659,499 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3116,635,256 - 116,656,956 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03109,710,151 - 109,732,678 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC35A5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13317,073,378 - 17,109,178 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3317,073,678 - 17,093,017 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3317,176,529 - 17,212,511 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03317,317,159 - 17,353,199 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3317,309,962 - 17,347,545 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13317,122,002 - 17,157,975 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03317,169,439 - 17,205,397 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03317,719,018 - 17,754,993 (+)NCBIUU_Cfam_GSD_1.0
Slc35a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602137,241,638 - 137,263,601 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936536258,288 - 280,280 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC35A5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13147,258,578 - 147,279,336 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113147,252,702 - 147,279,386 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213156,836,045 - 156,876,778 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC35A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12268,205,783 - 68,227,717 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2268,208,604 - 68,226,340 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604198,234,633 - 98,255,334 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc35a5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473135,944,545 - 35,978,450 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473135,944,545 - 35,978,470 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc35a5
47 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:408
Count of miRNA genes:224
Interacting mature miRNAs:257
Transcripts:ENSRNOT00000002853
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 8 19 68 24 36 11
Low 2 43 49 41 41 8 11 6 11 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002853   ⟹   ENSRNOP00000002853
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,653,394 - 55,674,443 (+)Ensembl
Rnor_6.0 Ensembl1160,613,882 - 60,634,851 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093223
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1160,632,878 - 60,633,638 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093457
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1160,614,905 - 60,621,333 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093508
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1160,624,977 - 60,625,369 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094087   ⟹   ENSRNOP00000081544
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,653,620 - 55,674,473 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098607   ⟹   ENSRNOP00000093430
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,653,620 - 55,674,443 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114720   ⟹   ENSRNOP00000086679
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,654,365 - 55,674,443 (+)Ensembl
RefSeq Acc Id: NM_001191927   ⟹   NP_001178856
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21155,653,404 - 55,673,693 (+)NCBI
Rnor_6.01160,613,898 - 60,634,066 (+)NCBI
Rnor_5.01164,716,008 - 64,737,004 (+)NCBI
Celera1155,219,430 - 55,239,646 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248342   ⟹   XP_006248404
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21155,653,630 - 55,674,476 (+)NCBI
Rnor_6.01160,614,092 - 60,634,849 (+)NCBI
Rnor_5.01164,716,008 - 64,737,004 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248343   ⟹   XP_006248405
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21155,653,627 - 55,674,476 (+)NCBI
Rnor_6.01160,614,091 - 60,634,849 (+)NCBI
Rnor_5.01164,716,008 - 64,737,004 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598044   ⟹   XP_017453533
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21155,653,379 - 55,674,476 (+)NCBI
Rnor_6.01160,613,865 - 60,634,849 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088576   ⟹   XP_038944504
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21155,653,376 - 55,674,476 (+)NCBI
RefSeq Acc Id: XM_039088577   ⟹   XP_038944505
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21155,654,345 - 55,674,476 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001178856   ⟸   NM_001191927
- UniProtKB: D4A7S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248405   ⟸   XM_006248343
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006248404   ⟸   XM_006248342
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AIR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453533   ⟸   XM_017598044
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000002853   ⟸   ENSRNOT00000002853
RefSeq Acc Id: XP_038944504   ⟸   XM_039088576
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038944505   ⟸   XM_039088577
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000086679   ⟸   ENSRNOT00000114720
RefSeq Acc Id: ENSRNOP00000093430   ⟸   ENSRNOT00000098607
RefSeq Acc Id: ENSRNOP00000081544   ⟸   ENSRNOT00000094087

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7S3-F1-model_v2 AlphaFold D4A7S3 1-438 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698143
Promoter ID:EPDNEW_R8667
Type:multiple initiation site
Name:Slc35a5_1
Description:solute carrier family 35, member A5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01160,613,895 - 60,613,955EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564361 AgrOrtholog
BioCyc Gene G2FUF-21373 BioCyc
Ensembl Genes ENSRNOG00000002069 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002853 ENTREZGENE
  ENSRNOP00000002853.3 UniProtKB/TrEMBL
  ENSRNOP00000081544.1 UniProtKB/TrEMBL
  ENSRNOP00000086679.1 UniProtKB/TrEMBL
  ENSRNOP00000093430 ENTREZGENE
  ENSRNOP00000093430.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002853 ENTREZGENE
  ENSRNOT00000002853.6 UniProtKB/TrEMBL
  ENSRNOT00000094087.1 UniProtKB/TrEMBL
  ENSRNOT00000098607 ENTREZGENE
  ENSRNOT00000098607.1 UniProtKB/TrEMBL
  ENSRNOT00000114720.1 UniProtKB/TrEMBL
InterPro Nuc_sug_transpt UniProtKB/TrEMBL
KEGG Report rno:498081 UniProtKB/TrEMBL
NCBI Gene 498081 ENTREZGENE
PANTHER Nuc_sug_transpt UniProtKB/TrEMBL
Pfam Nuc_sug_transp UniProtKB/TrEMBL
PhenoGen Slc35a5 PhenoGen
PIRSF UDP-gal_transpt UniProtKB/TrEMBL
UniProt A0A8I5ZSF7_RAT UniProtKB/TrEMBL
  A0A8I6A454_RAT UniProtKB/TrEMBL
  A0A8I6AIR5 ENTREZGENE, UniProtKB/TrEMBL
  D4A7S3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Slc35a5  solute carrier family 35, member A5  RGD1564361_predicted  similar to solute carrier family 35, member A5 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564361_predicted  similar to solute carrier family 35, member A5 (predicted)  LOC498081  similar to solute carrier family 35, member A5  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498081  similar to solute carrier family 35, member A5      Symbol and Name status set to provisional 70820 PROVISIONAL