Lmln (leishmanolysin like peptidase) - Rat Genome Database

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Gene: Lmln (leishmanolysin like peptidase) Rattus norvegicus
Analyze
Symbol: Lmln
Name: leishmanolysin like peptidase
RGD ID: 1311465
Description: Predicted to enable peptidase activity. Predicted to be involved in cell adhesion and proteolysis. Predicted to be located in cytosol and focal adhesion. Predicted to be active in cytoplasm. Orthologous to human LMLN (leishmanolysin like peptidase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leishmanolysin-like (metallopeptidase M8 family); leishmanolysin-like peptidase; LOC363795
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: LmlnTn(sb-T2/Bart3)2.322Mcwi  
Genetic Models: F344-LmlnTn(sb-T2/Bart3)2.322Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,161,330 - 81,230,972 (-)NCBIGRCr8
mRatBN7.21167,656,241 - 67,725,889 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1167,658,152 - 67,724,243 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1176,495,203 - 76,561,218 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,157,017 - 69,223,029 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,184,293 - 68,250,306 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,895,141 - 70,963,121 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,897,052 - 70,961,358 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,980,288 - 74,048,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,481,117 - 69,547,133 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11169,540,938 - 69,605,571 (-)NCBI
Celera1167,105,608 - 67,170,858 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (ISO)
focal adhesion  (ISO)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation

Genomics

Comparative Map Data
Lmln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81181,161,330 - 81,230,972 (-)NCBIGRCr8
mRatBN7.21167,656,241 - 67,725,889 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1167,658,152 - 67,724,243 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1176,495,203 - 76,561,218 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,157,017 - 69,223,029 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01168,184,293 - 68,250,306 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,895,141 - 70,963,121 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,897,052 - 70,961,358 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,980,288 - 74,048,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,481,117 - 69,547,133 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11169,540,938 - 69,605,571 (-)NCBI
Celera1167,105,608 - 67,170,858 (-)NCBICelera
Cytogenetic Map11q22NCBI
LMLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383197,960,217 - 198,043,720 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3197,960,200 - 198,043,720 (+)EnsemblGRCh38hg38GRCh38
GRCh373197,687,088 - 197,770,591 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363199,171,468 - 199,254,988 (+)NCBINCBI36Build 36hg18NCBI36
Build 343199,175,380 - 199,253,878NCBI
Celera3196,303,224 - 196,385,377 (+)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3194,989,555 - 195,071,146 (+)NCBIHuRef
CHM1_13197,657,991 - 197,740,784 (+)NCBICHM1_1
T2T-CHM13v2.03200,692,672 - 200,776,106 (+)NCBIT2T-CHM13v2.0
Lmln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,881,974 - 32,948,065 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,882,891 - 32,948,065 (+)EnsemblGRCm39 Ensembl
GRCm381633,061,870 - 33,127,695 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1633,062,521 - 33,127,695 (+)EnsemblGRCm38mm10GRCm38
MGSCv371633,062,607 - 33,125,745 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361632,982,268 - 33,045,406 (+)NCBIMGSCv36mm8
Celera1633,541,917 - 33,604,956 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1623.6NCBI
Lmln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542011,867,465 - 11,953,266 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542011,867,034 - 11,953,303 (-)NCBIChiLan1.0ChiLan1.0
LMLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22195,891,976 - 196,004,525 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13195,899,788 - 196,012,338 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03195,396,514 - 195,477,580 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13205,268,896 - 205,348,412 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3205,268,896 - 205,348,412 (+)Ensemblpanpan1.1panPan2
LMLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13328,648,742 - 28,738,499 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3328,655,631 - 28,738,568 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3328,670,581 - 28,759,784 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03328,881,987 - 28,971,189 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3328,888,355 - 28,971,265 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13328,677,907 - 28,766,633 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03328,723,414 - 28,812,625 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03329,344,364 - 29,434,119 (-)NCBIUU_Cfam_GSD_1.0
Lmln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602125,720,618 - 125,791,544 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493678493,725 - 164,968 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493678493,734 - 164,686 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LMLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13134,596,150 - 134,656,744 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113134,596,116 - 134,656,751 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213144,253,451 - 144,301,272 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LMLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11591,676,060 - 91,745,251 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1591,676,379 - 91,744,928 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604165,626,595 - 65,697,207 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lmln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473060,818,084 - 60,872,030 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473060,817,980 - 60,872,046 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lmln
406 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:660
Count of miRNA genes:287
Interacting mature miRNAs:351
Transcripts:ENSRNOT00000002427
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat

Markers in Region
D11Rat62  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21167,715,058 - 67,715,230 (+)MAPPERmRatBN7.2
Rnor_6.01170,952,019 - 70,952,190NCBIRnor6.0
Rnor_5.01174,036,980 - 74,037,151UniSTSRnor5.0
RGSC_v3.41169,538,032 - 69,538,204RGDRGSC3.4
RGSC_v3.41169,538,033 - 69,538,204UniSTSRGSC3.4
RGSC_v3.11169,595,613 - 69,595,967RGD
Celera1167,161,758 - 67,161,929UniSTS
SHRSP x BN Map1132.1299RGD
SHRSP x BN Map1132.1299UniSTS
Cytogenetic Map11q22UniSTS
D11Got118  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21167,717,558 - 67,717,650 (+)MAPPERmRatBN7.2
Rnor_6.01170,954,756 - 70,954,847NCBIRnor6.0
Rnor_5.01174,039,717 - 74,039,808UniSTSRnor5.0
RGSC_v3.41169,540,531 - 69,540,622UniSTSRGSC3.4
Celera1167,164,256 - 67,164,347UniSTS
Cytogenetic Map11q22UniSTS


Genetic Models
This gene Lmln is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 6 12 6
Low 3 43 38 28 13 28 8 9 62 35 35 11 8
Below cutoff 13 13 13 2

Sequence


RefSeq Acc Id: ENSRNOT00000002427   ⟹   ENSRNOP00000002427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1167,658,152 - 67,724,243 (-)Ensembl
Rnor_6.0 Ensembl1170,897,052 - 70,961,358 (-)Ensembl
RefSeq Acc Id: NM_001415730   ⟹   NP_001402659
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,161,330 - 81,229,195 (-)NCBI
mRatBN7.21167,656,241 - 67,724,112 (-)NCBI
RefSeq Acc Id: XM_039088544   ⟹   XP_038944472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81181,179,582 - 81,230,972 (-)NCBI
mRatBN7.21167,676,287 - 67,725,889 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001402659 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944472 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11372 (Get FASTA)   NCBI Sequence Viewer  
  EDM11373 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002427
  ENSRNOP00000002427.6
RefSeq Acc Id: ENSRNOP00000002427   ⟸   ENSRNOT00000002427
RefSeq Acc Id: XP_038944472   ⟸   XM_039088544
- Peptide Label: isoform X1
- UniProtKB: A6IRM0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402659   ⟸   NM_001415730
- Peptide Label: precursor
- UniProtKB: D4AC69 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AC69-F1-model_v2 AlphaFold D4AC69 1-707 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698202
Promoter ID:EPDNEW_R8727
Type:single initiation site
Name:Lmln_1
Description:leishmanolysin like peptidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01170,961,283 - 70,961,343EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311465 AgrOrtholog
BioCyc Gene G2FUF-21122 BioCyc
Ensembl Genes ENSRNOG00000001781 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002427 ENTREZGENE
  ENSRNOT00000002427.6 UniProtKB/TrEMBL
Gene3D-CATH 3.10.170.20 UniProtKB/TrEMBL
  Leishmanolysin , domain 2 UniProtKB/TrEMBL
  Leishmanolysin domain 3 UniProtKB/TrEMBL
InterPro Peptidase_M8 UniProtKB/TrEMBL
KEGG Report rno:363795 UniProtKB/TrEMBL
NCBI Gene 363795 ENTREZGENE
PANTHER LEISHMANOLYSIN-LIKE PEPTIDASE UniProtKB/TrEMBL
  Peptidase_M8 UniProtKB/TrEMBL
Pfam Peptidase_M8 UniProtKB/TrEMBL
PhenoGen Lmln PhenoGen
RatGTEx ENSRNOG00000001781 RatGTEx
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A6IRM0 ENTREZGENE, UniProtKB/TrEMBL
  D4AC69 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Lmln  leishmanolysin-like (metallopeptidase M8 family)   Lmln_predicted  leishmanolysin-like (metallopeptidase M8 family) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lmln_predicted  leishmanolysin-like (metallopeptidase M8 family) (predicted)      Symbol and Name status set to approved 70820 APPROVED