Slc5a3 (solute carrier family 5 member 3) - Rat Genome Database

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Gene: Slc5a3 (solute carrier family 5 member 3) Rattus norvegicus
Analyze
Symbol: Slc5a3
Name: solute carrier family 5 member 3
RGD ID: 621530
Description: Predicted to enable several functions, including monosaccharide transmembrane transporter activity; myo-inositol:sodium symporter activity; and transmembrane transporter binding activity. Predicted to be involved in monosaccharide transmembrane transport; polyol transmembrane transport; and regulation of transporter activity. Predicted to act upstream of or within several processes, including inositol metabolic process; myo-inositol transport; and positive regulation of reactive oxygen species biosynthetic process. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and perinuclear region of cytoplasm. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human SLC5A3 (solute carrier family 5 member 3); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Smit; sodium/myo-inositol cotransporter; solute carrier family 5 (inositol transporters), member 3; solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21131,313,847 - 31,316,293 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1131,295,476 - 31,318,883 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,008,115 - 40,010,560 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01132,679,563 - 32,682,008 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01131,843,057 - 31,845,503 (+)NCBIRnor_WKY
Rnor_6.01132,229,366 - 32,231,812 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01135,834,279 - 35,836,725 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,063,275 - 32,065,721 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11132,119,576 - 32,121,733 (+)NCBI
Celera1130,970,690 - 30,973,136 (+)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
allopurinol  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
cefaloridine  (EXP)
chrysene  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
diprotium oxide  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
folic acid  (ISO)
genistein  (ISO)
heparin  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
inositol  (ISO)
ketamine  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (EXP)
methylarsonic acid  (ISO)
myxothiazol  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalenes  (EXP)
oxaliplatin  (EXP)
paracetamol  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(vinylpyrrolidone)  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
ranitidine  (EXP)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
succimer  (ISO)
sunitinib  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
water  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Differential expression, activity and regulation of the sodium/myo-inositol cotransporter in astrocyte cultures from different regions of the rat brain. Lubrich B, etal., Neuropharmacology 2000 Feb 14;39(4):680-90.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7537337   PMID:8889548   PMID:12098491   PMID:12427139   PMID:12582158   PMID:12719585   PMID:16174787   PMID:16644257   PMID:18675571   PMID:25756525   PMID:28202581   PMID:28793216  
PMID:29551423   PMID:32787517  


Genomics

Comparative Map Data
Slc5a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21131,313,847 - 31,316,293 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1131,295,476 - 31,318,883 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,008,115 - 40,010,560 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01132,679,563 - 32,682,008 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01131,843,057 - 31,845,503 (+)NCBIRnor_WKY
Rnor_6.01132,229,366 - 32,231,812 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01135,834,279 - 35,836,725 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,063,275 - 32,065,721 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11132,119,576 - 32,121,733 (+)NCBI
Celera1130,970,690 - 30,973,136 (+)NCBICelera
Cytogenetic Map11q11NCBI
SLC5A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382134,073,578 - 34,106,260 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2134,073,578 - 34,106,260 (+)EnsemblGRCh38hg38GRCh38
GRCh372135,445,878 - 35,478,559 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362134,367,740 - 34,400,431 (+)NCBINCBI36Build 36hg18NCBI36
Build 342134,389,367 - 34,391,524NCBI
Celera2120,645,433 - 20,678,122 (+)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2120,945,609 - 20,957,018 (+)NCBIHuRef
CHM1_12135,008,142 - 35,040,833 (+)NCBICHM1_1
T2T-CHM13v2.02132,455,648 - 32,488,333 (+)NCBIT2T-CHM13v2.0
Slc5a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391691,855,210 - 91,884,361 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1691,855,210 - 91,884,361 (+)EnsemblGRCm39 Ensembl
GRCm381692,058,322 - 92,087,473 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1692,058,322 - 92,087,473 (+)EnsemblGRCm38mm10GRCm38
MGSCv371692,058,567 - 92,087,718 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361691,965,916 - 91,968,072 (+)NCBIMGSCv36mm8
Celera1693,161,374 - 93,172,132 (+)NCBICelera
Cytogenetic Map16C4NCBI
Slc5a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540733,494,816 - 33,511,968 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540733,460,238 - 33,511,889 (+)NCBIChiLan1.0ChiLan1.0
MRPS6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12133,809,456 - 33,879,670 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2133,862,033 - 33,879,670 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02120,441,365 - 20,510,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC5A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13128,610,332 - 28,635,233 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3128,610,332 - 28,635,233 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3128,607,798 - 28,632,691 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03128,815,044 - 28,839,960 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3128,815,024 - 28,840,301 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13128,681,748 - 28,706,621 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03128,696,566 - 28,721,418 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03129,195,487 - 29,220,373 (+)NCBIUU_Cfam_GSD_1.0
Slc5a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497129,152,449 - 29,183,192 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365008,284,631 - 8,296,387 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC5A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13197,711,679 - 197,718,695 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113197,688,632 - 197,723,323 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC5A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1258,104,938 - 58,131,225 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666071601,202 - 634,141 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc5a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474522,231,887 - 22,258,965 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474522,231,434 - 22,264,555 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc5a3
5 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat

Markers in Region
UniSTS:259143  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,315,417 - 31,315,546 (+)MAPPERmRatBN7.2
Rnor_6.01132,230,937 - 32,231,065NCBIRnor6.0
Rnor_5.01135,835,850 - 35,835,978UniSTSRnor5.0
RGSC_v3.41132,064,846 - 32,064,974UniSTSRGSC3.4
Celera1130,972,261 - 30,972,389UniSTS
Cytogenetic Map11q11UniSTS
BI279882  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,316,132 - 31,316,282 (+)MAPPERmRatBN7.2
Rnor_6.01132,231,652 - 32,231,801NCBIRnor6.0
Rnor_5.01135,836,565 - 35,836,714UniSTSRnor5.0
RGSC_v3.41132,065,561 - 32,065,710UniSTSRGSC3.4
Celera1130,972,976 - 30,973,125UniSTS
RH 3.4 Map11201.9UniSTS
Cytogenetic Map11q11UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000107838   ⟹   ENSRNOP00000097788
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,295,476 - 31,318,883 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112717   ⟹   ENSRNOP00000093318
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,306,650 - 31,317,421 (+)Ensembl
RefSeq Acc Id: NM_053715   ⟹   NP_446167
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21131,313,847 - 31,316,293 (+)NCBI
Rnor_6.01132,229,366 - 32,231,812 (+)NCBI
Rnor_5.01135,834,279 - 35,836,725 (+)NCBI
RGSC_v3.41132,063,275 - 32,065,721 (+)RGD
Celera1130,970,690 - 30,973,136 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446167 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD10831 (Get FASTA)   NCBI Sequence Viewer  
  AAO73471 (Get FASTA)   NCBI Sequence Viewer  
  CAA04650 (Get FASTA)   NCBI Sequence Viewer  
  EDM10751 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446167   ⟸   NM_053715
- UniProtKB: Q80WA5 (UniProtKB/TrEMBL),   A0A8I6GM79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000097788   ⟸   ENSRNOT00000107838
RefSeq Acc Id: ENSRNOP00000093318   ⟸   ENSRNOT00000112717

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621530 AgrOrtholog
BioCyc Gene G2FUF-21864 BioCyc
Ensembl Genes ENSRNOG00000067988 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000093318.1 UniProtKB/TrEMBL
  ENSRNOP00000097788 ENTREZGENE
  ENSRNOP00000097788.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000107838 ENTREZGENE
  ENSRNOT00000107838.1 UniProtKB/TrEMBL
  ENSRNOT00000112717.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1730.10 UniProtKB/TrEMBL
InterPro Na/Glc_symporter_sf UniProtKB/TrEMBL
  Na/solute_symporter UniProtKB/TrEMBL
  Na/solute_symporter_CS UniProtKB/TrEMBL
  SMIT UniProtKB/TrEMBL
KEGG Report rno:114507 UniProtKB/TrEMBL
NCBI Gene 114507 ENTREZGENE
Pfam SSF UniProtKB/TrEMBL
PhenoGen Slc5a3 PhenoGen
PROSITE NA_SOLUT_SYMP_1 UniProtKB/TrEMBL
  NA_SOLUT_SYMP_2 UniProtKB/TrEMBL
  NA_SOLUT_SYMP_3 UniProtKB/TrEMBL
TIGRFAMs Sss UniProtKB/TrEMBL
UniProt A0A8I6GM79 ENTREZGENE, UniProtKB/TrEMBL
  Q80WA5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc5a3  solute carrier family 5 member 3  Slc5a3  solute carrier family 5 (sodium/myo-inositol cotransporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Slc5a3  solute carrier family 5 (inositol transporters), member 3      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Slc5a3  solute carrier family 5 (inositol transporters), member 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression active in the astrocytes in the cerebellum, cortex, diencephalon, hippocampus and tegmentum of the rat brain 634216