Adamts1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1) - Rat Genome Database

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Gene: Adamts1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1) Rattus norvegicus
Analyze
Symbol: Adamts1
Name: ADAM metallopeptidase with thrombospondin type 1 motif, 1
RGD ID: 621241
Description: Predicted to enable heparin binding activity and metalloendopeptidase activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; cellular response to prostaglandin E stimulus; and cellular response to vitamin D. Located in collagen-containing extracellular matrix. Biomarker of brain ischemia; myocardial infarction; transient cerebral ischemia; ureteral obstruction; and visual epilepsy. Orthologous to human ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif 1); INTERACTS WITH 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: A disintegrin and metalloproteinase with thrombospondin motifs 1; a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1); a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1; a disintegrin-like and metallopeptidse (reprolysin type) with thrombospondin type 1 motif, 1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1; ADAM-TS 1; ADAM-TS1; ADAMTS-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81138,418,565 - 38,427,384 (-)NCBIGRCr8
mRatBN7.21124,932,227 - 24,941,068 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1124,931,761 - 24,941,103 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1133,624,075 - 33,632,896 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01126,324,337 - 26,333,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01125,513,220 - 25,522,042 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01125,342,119 - 25,350,938 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1125,342,126 - 25,350,974 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,966,006 - 28,974,872 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41125,434,262 - 25,443,144 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11125,433,799 - 25,443,150 (-)NCBI
Celera1124,733,382 - 24,742,203 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
ciprofibrate  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenamidone  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
furan  (EXP,ISO)
furosemide  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (EXP)
heparin  (EXP)
hydrogen cyanide  (ISO)
hydroxyflutamide  (ISO)
indometacin  (ISO)
inulin  (ISO)
irinotecan  (EXP)
iron dichloride  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methimazole  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
rimonabant  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sotorasib  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tanespimycin  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trametinib  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vancomycin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor. Basile DP, etal., Am J Physiol Renal Physiol. 2008 Apr;294(4):F928-36. doi: 10.1152/ajprenal.00596.2007. Epub 2008 Feb 13.
2. ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes. Cross AK, etal., Brain Res. 2006 May 9;1088(1):19-30. Epub 2006 Apr 21.
3. Cloning of the rat ADAMTS-1 gene and its down regulation in endothelial cells in cirrhotic rats. Diamantis I, etal., Liver 2000 Apr;20(2):165-72.
4. Ovarian expression of a disintegrin and metalloproteinase with thrombospondin motifs during ovulation in the gonadotropin-primed immature rat. Espey LL, etal., Biol Reprod 2000 Apr;62(4):1090-5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. The hyalectan degrading ADAMTS-1 enzyme is expressed by osteoblasts and up-regulated at regions of new bone formation. Lind T, etal., Bone. 2005 Mar;36(3):408-17.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. ADAMTS-1: A cellular disintegrin and metalloprotease with thrombospondin motifs is a target for parathyroid hormone in bone. Miles RR, etal., Endocrinology. 2000 Dec;141(12):4533-42.
10. Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction. Nakamura A, etal., Exp Toxicol Pathol. 2007 Sep;59(1):1-7. Epub 2007 Jun 20.
11. Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction. Nakamura K, etal., J Biochem. 2004 Oct;136(4):439-46.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Proteomic evaluation of inflammatory proteins in rat spleen interstitial fluid and lymph during LPS-induced systemic inflammation reveals increased levels of ADAMST1. Oveland E, etal., J Proteome Res. 2012 Nov 2;11(11):5338-49. doi: 10.1021/pr3005666. Epub 2012 Oct 24.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons. Roet KC, etal., J Neurosci. 2013 Jul 3;33(27):11116-35. doi: 10.1523/JNEUROSCI.1002-13.2013.
19. A disintegrin and metalloprotease with thrombospondin type1 motifs (ADAMTS-1) and IL-1 receptor type 1 mRNAs are simultaneously induced in nerve injured motor neurons. Sasaki M, etal., Brain Res Mol Brain Res. 2001 Apr 18;89(1-2):158-63.
20. Expression of versican and ADAMTS during rat tooth eruption. Sone S, etal., J Mol Histol. 2005 May;36(4):281-8.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. The quantification of ADAMTS expression in an animal model of cerebral ischemia using real-time PCR. Tian YF, etal., Acta Anaesthesiol Scand. 2007 Feb;51(2):158-64. Epub 2006 Nov 1.
23. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy. Yokoyama H, etal., Nephrol Dial Transplant 2002;17 Suppl 9:39-41.
24. Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats. Yuan W, etal., Neuroscience. 2002;114(4):1091-101.
Additional References at PubMed
PMID:8995297   PMID:9593739   PMID:10438512   PMID:11278559   PMID:12907688   PMID:14668204   PMID:16061471   PMID:16583222   PMID:18267097   PMID:20665671   PMID:21092652   PMID:21362315  
PMID:28890348   PMID:37424113  


Genomics

Comparative Map Data
Adamts1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81138,418,565 - 38,427,384 (-)NCBIGRCr8
mRatBN7.21124,932,227 - 24,941,068 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1124,931,761 - 24,941,103 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1133,624,075 - 33,632,896 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01126,324,337 - 26,333,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01125,513,220 - 25,522,042 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01125,342,119 - 25,350,938 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1125,342,126 - 25,350,974 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,966,006 - 28,974,872 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41125,434,262 - 25,443,144 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11125,433,799 - 25,443,150 (-)NCBI
Celera1124,733,382 - 24,742,203 (-)NCBICelera
Cytogenetic Map11q11NCBI
ADAMTS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382126,835,755 - 26,845,409 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2126,835,755 - 26,845,409 (-)EnsemblGRCh38hg38GRCh38
GRCh372128,208,074 - 28,217,728 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,130,477 - 27,139,599 (-)NCBINCBI36Build 36hg18NCBI36
Build 342127,130,478 - 27,139,599NCBI
Celera2113,391,944 - 13,401,066 (-)NCBICelera
Cytogenetic Map21q21.3NCBI
HuRef2113,613,149 - 13,622,273 (-)NCBIHuRef
CHM1_12127,770,054 - 27,779,178 (-)NCBICHM1_1
T2T-CHM13v2.02125,193,845 - 25,203,500 (-)NCBIT2T-CHM13v2.0
Adamts1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391685,590,715 - 85,600,001 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1685,590,715 - 85,600,001 (-)EnsemblGRCm39 Ensembl
GRCm381685,793,827 - 85,803,113 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1685,793,827 - 85,803,113 (-)EnsemblGRCm38mm10GRCm38
MGSCv371685,794,072 - 85,803,360 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361685,683,023 - 85,692,295 (-)NCBIMGSCv36mm8
Celera1686,012,366 - 86,021,639 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1648.2NCBI
Adamts1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540726,524,130 - 26,533,038 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540726,524,487 - 26,533,038 (-)NCBIChiLan1.0ChiLan1.0
ADAMTS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22223,020,036 - 23,030,193 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12117,883,284 - 17,891,842 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02113,270,668 - 13,279,217 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12126,656,370 - 26,665,485 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2126,656,370 - 26,665,485 (-)Ensemblpanpan1.1panPan2
ADAMTS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13122,169,821 - 22,178,879 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3122,170,381 - 22,178,945 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3122,164,233 - 22,172,787 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03122,267,999 - 22,276,520 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3122,268,005 - 22,276,627 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13122,240,472 - 22,248,981 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03122,246,052 - 22,254,554 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03122,720,934 - 22,729,448 (-)NCBIUU_Cfam_GSD_1.0
Adamts1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497122,713,285 - 22,721,753 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936640959,417 - 968,842 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936640959,405 - 967,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13190,276,430 - 190,286,214 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113190,277,175 - 190,285,957 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213200,127,201 - 200,135,962 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1265,376,288 - 65,385,398 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl265,376,310 - 65,385,918 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660718,023,555 - 8,032,659 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474514,802,371 - 14,811,203 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474514,802,703 - 14,811,568 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adamts1
27 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:113
Interacting mature miRNAs:124
Transcripts:ENSRNOT00000002187
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)111283104625121472Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat

Markers in Region
A005R14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,932,146 - 24,932,269 (+)MAPPERmRatBN7.2
Rnor_6.01125,342,039 - 25,342,161NCBIRnor6.0
Rnor_5.01128,965,926 - 28,966,048UniSTSRnor5.0
RGSC_v3.41125,434,182 - 25,434,304UniSTSRGSC3.4
Celera1124,733,302 - 24,733,424UniSTS
Cytogenetic Map11q11-q22UniSTS
AI237630  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,932,365 - 24,932,463 (+)MAPPERmRatBN7.2
Rnor_6.01125,342,258 - 25,342,355NCBIRnor6.0
Rnor_5.01128,966,145 - 28,966,242UniSTSRnor5.0
RGSC_v3.41125,434,401 - 25,434,498UniSTSRGSC3.4
Celera1124,733,521 - 24,733,618UniSTS
RH 3.4 Map11116.0UniSTS
Cytogenetic Map11q11-q22UniSTS
Adamts1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,934,669 - 24,935,861 (+)MAPPERmRatBN7.2
Rnor_6.01125,344,562 - 25,345,753NCBIRnor6.0
Rnor_5.01128,968,449 - 28,969,640UniSTSRnor5.0
RGSC_v3.41125,436,705 - 25,437,896UniSTSRGSC3.4
Celera1124,735,825 - 24,737,016UniSTS
Cytogenetic Map11q11-q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002187   ⟹   ENSRNOP00000002187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1124,931,761 - 24,941,103 (-)Ensembl
Rnor_6.0 Ensembl1125,342,126 - 25,350,974 (-)Ensembl
RefSeq Acc Id: NM_024400   ⟹   NP_077376
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81138,418,565 - 38,427,384 (-)NCBI
mRatBN7.21124,932,227 - 24,941,068 (-)NCBI
Rnor_6.01125,342,119 - 25,350,938 (-)NCBI
Rnor_5.01128,966,006 - 28,974,872 (-)NCBI
RGSC_v3.41125,434,262 - 25,443,144 (-)RGD
Celera1124,733,382 - 24,742,203 (-)RGD
Sequence:
RefSeq Acc Id: NP_077376   ⟸   NM_024400
- Peptide Label: precursor
- UniProtKB: Q9WUQ1 (UniProtKB/Swiss-Prot),   Q9ERI1 (UniProtKB/Swiss-Prot),   Q68EJ2 (UniProtKB/TrEMBL),   F7FAV8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002187   ⟸   ENSRNOT00000002187
Protein Domains
Disintegrin   Peptidase M12B   TSP type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUQ1-F1-model_v2 AlphaFold Q9WUQ1 1-967 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698017
Promoter ID:EPDNEW_R8542
Type:single initiation site
Name:Adamts1_1
Description:ADAM metallopeptidase with thrombospondin type 1 motif, 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01125,350,976 - 25,351,036EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621241 AgrOrtholog
BioCyc Gene G2FUF-22075 BioCyc
Ensembl Genes ENSRNOG00000001607 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055002287 UniProtKB/Swiss-Prot
  ENSRNOG00060016911 UniProtKB/Swiss-Prot
  ENSRNOG00065006341 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002187.8 UniProtKB/TrEMBL
  ENSRNOT00055003641 UniProtKB/Swiss-Prot
  ENSRNOT00060028918 UniProtKB/Swiss-Prot
  ENSRNOT00065009726 UniProtKB/Swiss-Prot
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.830 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.1620.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7100443 IMAGE-MGC_LOAD
InterPro ADAM_CR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_Cys-rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS_ADAMTS-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M12B_ADAM-TS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79252 UniProtKB/TrEMBL
MGC_CLONE MGC:91667 IMAGE-MGC_LOAD
NCBI Gene 79252 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADAM_CR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_ADAMTS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adamts1 PhenoGen
PRINTS ADAMTS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTSFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001607 RatGTEx
  ENSRNOG00055002287 RatGTEx
  ENSRNOG00060016911 RatGTEx
  ENSRNOG00065006341 RatGTEx
SMART ACR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ATS1_RAT UniProtKB/Swiss-Prot
  F7FAV8 ENTREZGENE, UniProtKB/TrEMBL
  Q68EJ2 ENTREZGENE, UniProtKB/TrEMBL
  Q9ERI1 ENTREZGENE
  Q9WUQ1 ENTREZGENE
UniProt Secondary Q9ERI1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adamts1  ADAM metallopeptidase with thrombospondin type 1 motif, 1  Adamts1  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-19 Adamts1  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1  Adamts1  a disintegrin-like and metallopeptidse (reprolysin type) with thrombospondin type 1 motif, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Adamts1  a disintegrin-like and metallopeptidse (reprolysin type) with thrombospondin type 1 motif, 1    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1  Name updated 1299863 APPROVED
2004-09-10 Adamts1  a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1    a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1)  Name updated 1299863 APPROVED
2002-08-07 Adamts1  a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease decresed expression is detected during induction of liver cirrhosis 631922
gene_domains contains thrombospondin type I motifs at the C-terminus as well as extracellular anchors 631922