Adamts1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1) - Rat Genome Database
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Gene: Adamts1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1) Rattus norvegicus
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Symbol: Adamts1
Name: ADAM metallopeptidase with thrombospondin type 1 motif, 1
RGD ID: 621241
Description: Predicted to have heparin binding activity and metalloendopeptidase activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to vitamin D; and tooth eruption. Localizes to collagen-containing extracellular matrix. Biomarker of brain ischemia; myocardial infarction; transient cerebral ischemia; ureteral obstruction; and visual epilepsy. Orthologous to human ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif 1); INTERACTS WITH 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: A disintegrin and metalloproteinase with thrombospondin motifs 1; a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1); a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1; a disintegrin-like and metallopeptidse (reprolysin type) with thrombospondin type 1 motif, 1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1; ADAM-TS 1; ADAM-TS1; ADAMTS-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21124,932,227 - 24,941,068 (-)NCBI
Rnor_6.0 Ensembl1125,342,126 - 25,350,974 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01125,342,119 - 25,350,938 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01128,966,006 - 28,974,872 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41125,434,262 - 25,443,144 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11125,433,799 - 25,443,150 (-)NCBI
Celera1124,733,382 - 24,742,203 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
ciprofibrate  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenamidone  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
furan  (EXP,ISO)
furosemide  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
heparin  (EXP)
hydroxyflutamide  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
parathion  (ISO)
phenformin  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
rimonabant  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tanespimycin  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
vancomycin  (ISO)
zoledronic acid  (ISO)

References

References - curated
1. Basile DP, etal., Am J Physiol Renal Physiol. 2008 Apr;294(4):F928-36. doi: 10.1152/ajprenal.00596.2007. Epub 2008 Feb 13.
2. Cross AK, etal., Brain Res. 2006 May 9;1088(1):19-30. Epub 2006 Apr 21.
3. Diamantis I, etal., Liver 2000 Apr;20(2):165-72.
4. Espey LL, etal., Biol Reprod 2000 Apr;62(4):1090-5.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. GOA data from the GO Consortium
7. Lind T, etal., Bone. 2005 Mar;36(3):408-17.
8. MGD data from the GO Consortium
9. Miles RR, etal., Endocrinology. 2000 Dec;141(12):4533-42.
10. Nakamura A, etal., Exp Toxicol Pathol. 2007 Sep;59(1):1-7. Epub 2007 Jun 20.
11. Nakamura K, etal., J Biochem. 2004 Oct;136(4):439-46.
12. NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Oveland E, etal., J Proteome Res. 2012 Nov 2;11(11):5338-49. doi: 10.1021/pr3005666. Epub 2012 Oct 24.
14. RGD automated data pipeline
15. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. RGD automated import pipeline for gene-chemical interactions
17. RGD comprehensive gene curation
18. Roet KC, etal., J Neurosci. 2013 Jul 3;33(27):11116-35. doi: 10.1523/JNEUROSCI.1002-13.2013.
19. Sasaki M, etal., Brain Res Mol Brain Res. 2001 Apr 18;89(1-2):158-63.
20. Sone S, etal., J Mol Histol. 2005 May;36(4):281-8.
21. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Tian YF, etal., Acta Anaesthesiol Scand. 2007 Feb;51(2):158-64. Epub 2006 Nov 1.
23. Yokoyama H, etal., Nephrol Dial Transplant 2002;17 Suppl 9:39-41.
24. Yuan W, etal., Neuroscience. 2002;114(4):1091-101.
Additional References at PubMed
PMID:8995297   PMID:9593739   PMID:10438512   PMID:11278559   PMID:12907688   PMID:14668204   PMID:16061471   PMID:16583222   PMID:18267097   PMID:20665671   PMID:21092652   PMID:21362315  
PMID:28890348  


Genomics

Comparative Map Data
Adamts1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21124,932,227 - 24,941,068 (-)NCBI
Rnor_6.0 Ensembl1125,342,126 - 25,350,974 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01125,342,119 - 25,350,938 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01128,966,006 - 28,974,872 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41125,434,262 - 25,443,144 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11125,433,799 - 25,443,150 (-)NCBI
Celera1124,733,382 - 24,742,203 (-)NCBICelera
Cytogenetic Map11q11NCBI
ADAMTS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2126,835,755 - 26,845,409 (-)EnsemblGRCh38hg38GRCh38
GRCh382126,835,755 - 26,845,409 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372128,208,074 - 28,217,728 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh372128,208,606 - 28,217,728 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,130,477 - 27,139,599 (-)NCBINCBI36hg18NCBI36
Build 342127,130,478 - 27,139,599NCBI
Celera2113,391,944 - 13,401,066 (-)NCBI
Cytogenetic Map21q21.3NCBI
HuRef2113,613,149 - 13,622,273 (-)NCBIHuRef
CHM1_12127,770,054 - 27,779,178 (-)NCBICHM1_1
Adamts1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391685,590,715 - 85,600,001 (-)NCBIGRCm39mm39
GRCm381685,793,827 - 85,803,113 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1685,793,827 - 85,803,113 (-)EnsemblGRCm38mm10GRCm38
MGSCv371685,794,072 - 85,803,360 (-)NCBIGRCm37mm9NCBIm37
MGSCv361685,683,023 - 85,692,295 (-)NCBImm8
Celera1686,012,366 - 86,021,639 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1648.2NCBI
Adamts1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540726,524,130 - 26,533,038 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540726,524,487 - 26,533,038 (-)NCBIChiLan1.0ChiLan1.0
ADAMTS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12126,656,370 - 26,665,485 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2126,656,370 - 26,665,485 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02113,270,668 - 13,279,217 (-)NCBIMhudiblu_PPA_v0panPan3
ADAMTS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3122,170,381 - 22,178,945 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13122,169,821 - 22,178,879 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Adamts1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936640959,405 - 967,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13190,276,424 - 190,286,205 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113190,277,175 - 190,285,957 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213200,127,201 - 200,135,962 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1265,376,288 - 65,385,398 (+)NCBI
ChlSab1.1 Ensembl265,376,310 - 65,385,918 (+)Ensembl
Adamts1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474514,802,703 - 14,811,568 (-)NCBI

Position Markers
A005R14  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01125,342,039 - 25,342,161NCBIRnor6.0
Rnor_5.01128,965,926 - 28,966,048UniSTSRnor5.0
RGSC_v3.41125,434,182 - 25,434,304UniSTSRGSC3.4
Celera1124,733,302 - 24,733,424UniSTS
Cytogenetic Map11q11-q22UniSTS
AI237630  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01125,342,258 - 25,342,355NCBIRnor6.0
Rnor_5.01128,966,145 - 28,966,242UniSTSRnor5.0
RGSC_v3.41125,434,401 - 25,434,498UniSTSRGSC3.4
Celera1124,733,521 - 24,733,618UniSTS
RH 3.4 Map11116.0UniSTS
Cytogenetic Map11q11-q22UniSTS
Adamts1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01125,344,562 - 25,345,753NCBIRnor6.0
Rnor_5.01128,968,449 - 28,969,640UniSTSRnor5.0
RGSC_v3.41125,436,705 - 25,437,896UniSTSRGSC3.4
Celera1124,735,825 - 24,737,016UniSTS
Cytogenetic Map11q11-q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11133867429Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11172720192Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)1132503169342559Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11935127454351274Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)111136730644444347Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111632197346583360Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111947517979734728Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)112194422966944229Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)112194422966944229Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)112204314944444112Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:113
Interacting mature miRNAs:124
Transcripts:ENSRNOT00000002187
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 36 13 12 12 8 8 7 35 32 11 8
Low 3 7 44 29 19 29 3 67 7
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002187   ⟹   ENSRNOP00000002187
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1125,342,126 - 25,350,974 (-)Ensembl
RefSeq Acc Id: NM_024400   ⟹   NP_077376
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21124,932,227 - 24,941,068 (-)NCBI
Rnor_6.01125,342,119 - 25,350,938 (-)NCBI
Rnor_5.01128,966,006 - 28,974,872 (-)NCBI
RGSC_v3.41125,434,262 - 25,443,144 (-)RGD
Celera1124,733,382 - 24,742,203 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_077376   ⟸   NM_024400
- Peptide Label: precursor
- UniProtKB: Q68EJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002187   ⟸   ENSRNOT00000002187
Protein Domains
Disintegrin   Peptidase M12B   TSP type-1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698017
Promoter ID:EPDNEW_R8542
Type:single initiation site
Name:Adamts1_1
Description:ADAM metallopeptidase with thrombospondin type 1 motif, 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01125,350,976 - 25,351,036EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621241 AgrOrtholog
Ensembl Genes ENSRNOG00000001607 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002187 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002187 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7100443 IMAGE-MGC_LOAD
InterPro ADAM_CR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_Cys-rich UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M12B_ADAM-TS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79252 UniProtKB/TrEMBL
MGC_CLONE MGC:91667 IMAGE-MGC_LOAD
NCBI Gene 79252 ENTREZGENE
Pfam ADAM_CR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adamts1 PhenoGen
PRINTS ADAMTS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAMTSFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART ACR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF82895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ATS1_RAT UniProtKB/Swiss-Prot
  Q68EJ2 ENTREZGENE, UniProtKB/TrEMBL
  Q9WUQ1 ENTREZGENE
UniProt Secondary Q9ERI1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adamts1  ADAM metallopeptidase with thrombospondin type 1 motif, 1  Adamts1  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-19 Adamts1  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1  Adamts1  a disintegrin-like and metallopeptidse (reprolysin type) with thrombospondin type 1 motif, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Adamts1  a disintegrin-like and metallopeptidse (reprolysin type) with thrombospondin type 1 motif, 1    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1  Name updated 1299863 APPROVED
2004-09-10 Adamts1  a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1    a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1)  Name updated 1299863 APPROVED
2002-08-07 Adamts1  a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease decresed expression is detected during induction of liver cirrhosis 631922
gene_domains contains thrombospondin type I motifs at the C-terminus as well as extracellular anchors 631922