RGD Reference Report - A disintegrin and metalloprotease with thrombospondin type1 motifs (ADAMTS-1) and IL-1 receptor type 1 mRNAs are simultaneously induced in nerve injured motor neurons. - Rat Genome Database

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A disintegrin and metalloprotease with thrombospondin type1 motifs (ADAMTS-1) and IL-1 receptor type 1 mRNAs are simultaneously induced in nerve injured motor neurons.

Authors: Sasaki, M  Seo-Kiryu, S  Kato, R  Kita, S  Kiyama, H 
Citation: Sasaki M, etal., Brain Res Mol Brain Res. 2001 Apr 18;89(1-2):158-63.
RGD ID: 5037239
Pubmed: (View Article at PubMed) PMID:11311987

Following rat hypoglossal nerve injury, expression of mRNAs for a disintegrin and metalloprotease with thrombospondin type1 motifs (ADAMTS-1) and IL-1 receptor type 1 (IL-1RT1) are induced in the injured motor neurons. Although N1E-115 (N1E) cells, which were treated with IL-1 alpha, showed no alteration of ADAMTS-1 mRNA expression, a substantial increase of ADAMTS-1 mRNA expression was observed in the N1E cells expressing IL-1RT1. These findings suggest that nerve injury promotes IL-1RT1 expression in the injured neurons and thereby ADAMTS-1 transcription was induced in response to IL-1 released from glial cells.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Adamts1  (ADAM metallopeptidase with thrombospondin type 1 motif, 1)
Il1r1  (interleukin 1 receptor type 1)

Genes (Mus musculus)
Adamts1  (a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1)
Il1r1  (interleukin 1 receptor, type I)

Genes (Homo sapiens)
ADAMTS1  (ADAM metallopeptidase with thrombospondin type 1 motif 1)
IL1R1  (interleukin 1 receptor type 1)


Additional Information