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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621241
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adamts1
Name: ADAM metallopeptidase with thrombospondin type 1 motif, 1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adamts1increases expressionISOADAMTS1 (Homo sapiens)6480464CTDProgesterone results in increased expression of ADAMTS1 mRNA; Progesterone results in increased expression of ADAMTS1 proteinPMID:17018655 PMID:20226447 PMID:20864642 PMID:21795739
Adamts1multiple interactionsISOADAMTS1 (Homo sapiens)6480464CTD[Progesterone co-treated with Dihydrotestosterone] results in increased expression of ADAMTS1 mRNA; [Progesterone co-treated with Dihydrotestosterone] results in increased expression of ADAMTS1 protein; [Progesterone co-treated with Estradiol] results in increased expression of ADAMTS1 mRNA; Estradiol inhibits the reaction [Progesterone results in increased expression of ADAMTS1 mRNA]; Estradiol inhibits the reaction [Progesterone results in increased expression of ADAMTS1 protein]; Mifepristone inhibits the reaction [Progesterone results in increased expression of ADAMTS1 mRNA]; Mifepristone inhibits the reaction [Progesterone results in increased expression of ADAMTS1 protein]PMID:17018655 PMID:20226447
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