Adamts1 (ADAM metallopeptidase with thrombospondin type 1 motif 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Adamts1 (ADAM metallopeptidase with thrombospondin type 1 motif 1) Ictidomys tridecemlineatus
Analyze
Symbol: Adamts1
Name: ADAM metallopeptidase with thrombospondin type 1 motif 1
RGD ID: 12477448
Description: ENCODES a protein that exhibits heparin binding (inferred); metal ion binding (inferred); metalloendopeptidase activity (inferred); INVOLVED IN cellular response to parathyroid hormone stimulus (ortholog); cellular response to prostaglandin E stimulus (ortholog); cellular response to vitamin D (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); brain ischemia (ortholog); Breast Neoplasms (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: A disintegrin and metalloproteinase with thrombospondin motifs 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497122,713,285 - 22,721,753 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936640959,417 - 968,842 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936640959,405 - 967,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Adamts1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497122,713,285 - 22,721,753 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936640959,417 - 968,842 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936640959,405 - 967,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382126,835,755 - 26,845,409 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2126,835,755 - 26,845,409 (-)EnsemblGRCh38hg38GRCh38
GRCh372128,208,074 - 28,217,728 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,130,477 - 27,139,599 (-)NCBINCBI36Build 36hg18NCBI36
Build 342127,130,478 - 27,139,599NCBI
Celera2113,391,944 - 13,401,066 (-)NCBICelera
Cytogenetic Map21q21.3NCBI
HuRef2113,613,149 - 13,622,273 (-)NCBIHuRef
CHM1_12127,770,054 - 27,779,178 (-)NCBICHM1_1
T2T-CHM13v2.02125,193,845 - 25,203,500 (-)NCBIT2T-CHM13v2.0
Adamts1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391685,590,715 - 85,600,001 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1685,590,715 - 85,600,001 (-)EnsemblGRCm39 Ensembl
GRCm381685,793,827 - 85,803,113 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1685,793,827 - 85,803,113 (-)EnsemblGRCm38mm10GRCm38
MGSCv371685,794,072 - 85,803,360 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361685,683,023 - 85,692,295 (-)NCBIMGSCv36mm8
Celera1686,012,366 - 86,021,639 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1648.2NCBI
Adamts1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81138,418,565 - 38,427,384 (-)NCBIGRCr8
mRatBN7.21124,932,227 - 24,941,068 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1124,931,761 - 24,941,103 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1133,624,075 - 33,632,896 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01126,324,337 - 26,333,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01125,513,220 - 25,522,042 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01125,342,119 - 25,350,938 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1125,342,126 - 25,350,974 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,966,006 - 28,974,872 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41125,434,262 - 25,443,144 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11125,433,799 - 25,443,150 (-)NCBI
Celera1124,733,382 - 24,742,203 (-)NCBICelera
Cytogenetic Map11q11NCBI
Adamts1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540726,524,130 - 26,533,038 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540726,524,487 - 26,533,038 (-)NCBIChiLan1.0ChiLan1.0
ADAMTS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22223,020,036 - 23,030,193 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12117,883,284 - 17,891,842 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02113,270,668 - 13,279,217 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12126,656,370 - 26,665,485 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2126,656,370 - 26,665,485 (-)Ensemblpanpan1.1panPan2
ADAMTS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13122,169,821 - 22,178,879 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3122,170,381 - 22,178,945 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3122,164,233 - 22,172,787 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03122,267,999 - 22,276,520 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3122,268,005 - 22,276,627 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13122,240,472 - 22,248,981 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03122,246,052 - 22,254,554 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03122,720,934 - 22,729,448 (-)NCBIUU_Cfam_GSD_1.0
ADAMTS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13190,276,430 - 190,286,214 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113190,277,175 - 190,285,957 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213200,127,201 - 200,135,962 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1265,376,288 - 65,385,398 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl265,376,310 - 65,385,918 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660718,023,555 - 8,032,659 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474514,802,371 - 14,811,203 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474514,802,703 - 14,811,568 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005335392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000025202   ⟹   ENSSTOP00000021533
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936640959,417 - 968,842 (+)Ensembl
RefSeq Acc Id: XM_005335392   ⟹   XP_005335449
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440497122,713,285 - 22,721,753 (-)NCBI
SpeTri2.0NW_004936640959,405 - 967,305 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005335449 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000021533.1
GenBank Protein KAG3283786 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005335449   ⟸   XM_005335392
- UniProtKB: I3NAY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000021533   ⟸   ENSSTOT00000025202
Protein Domains
Peptidase M12B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000025243 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000025202.2 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  2.60.120.830 UniProtKB/TrEMBL
  3.40.1620.60 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_Cys-rich UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Pept_M12B_ADAM-TS1 UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
NCBI Gene Adamts1 ENTREZGENE
PANTHER A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 1 UniProtKB/TrEMBL
  ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE UniProtKB/TrEMBL
Pfam ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
  TSP1_ADAMTS UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PRINTS ADAMTS1 UniProtKB/TrEMBL
  ADAMTSFAMILY UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF82895 UniProtKB/TrEMBL
UniProt I3NAY6 ENTREZGENE, UniProtKB/TrEMBL