Opa1 (OPA1, mitochondrial dynamin like GTPase) - Rat Genome Database

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Gene: Opa1 (OPA1, mitochondrial dynamin like GTPase) Rattus norvegicus
Analyze
Symbol: Opa1
Name: OPA1, mitochondrial dynamin like GTPase
RGD ID: 708423
Description: Enables kinase binding activity. Involved in several processes, including cellular response to L-glutamate; mitochondrion organization; and positive regulation of cellular component organization. Located in cytosol. Is extrinsic component of mitochondrial inner membrane. Colocalizes with mitochondrion. Used to study transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease; fatty liver disease; ocular hypertension; and rhinitis. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase); PARTICIPATES IN mitochondria fusion pathway; INTERACTS WITH 2,6-dinitrotoluene; 4-DAMP(1+); acrolein.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dynamin-like 120 kDa protein, mitochondrial; LOC171116; MGC124921; mitochondrial OPA1; optic atrophy 1; optic atrophy 1 (autosomal dominant); optic atrophy 1 homolog; optic atrophy 1 homolog (human); optic atrophy 1-like protein; optic atrophy protein 1 homolog; RN protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21171,108,100 - 71,185,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1171,109,873 - 71,185,109 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1179,954,641 - 80,028,866 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01172,589,604 - 72,663,829 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01171,643,710 - 71,718,085 (-)NCBIRnor_WKY
Rnor_6.01174,717,600 - 74,793,902 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,720,254 - 74,793,803 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,761,813 - 77,840,630 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41173,005,470 - 73,058,136 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11173,063,058 - 73,115,780 (-)NCBI
Celera1170,077,956 - 70,151,932 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-DAMP(1+)  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
acetaldehyde  (ISO)
aconitine  (ISO)
acrolein  (EXP,ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carnosic acid  (ISO)
CCCP  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
curcumin  (EXP)
cycloheximide  (EXP)
D-glucose  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dieldrin  (EXP)
dioxygen  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
efavirenz  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fenbendazole  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
glucose  (EXP,ISO)
hexadecanoic acid  (ISO)
Honokiol  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
lamivudine  (ISO)
lenvatinib  (EXP)
Licarin A  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP,ISO)
metformin  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP)
nitrogen dioxide  (ISO)
okadaic acid  (EXP)
oxidopamine  (EXP,ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenethyl caffeate  (EXP)
piroxicam  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
regorafenib  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
Salvianolic acid A  (EXP,ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
silibinin  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
sulfur dioxide  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
trans-cinnamic acid  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
verteporfin  (EXP)
vinclozolin  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
apoptotic process  (IEA)
calcium import into the mitochondrion  (IMP)
cellular response to glucose stimulus  (IEP)
cellular response to hypoxia  (IEP)
cellular response to L-glutamate  (IEP)
cellular senescence  (ISO,ISS)
cochlea development  (IEP)
GTP metabolic process  (ISO,ISS)
inner mitochondrial membrane organization  (ISO,ISS)
intracellular distribution of mitochondria  (IMP)
membrane tubulation  (ISO,ISS)
mitochondrial fusion  (IBA,ISO,ISS)
mitochondrial genome maintenance  (ISO,ISS)
mitochondrion morphogenesis  (IMP)
mitochondrion organization  (IDA,IEA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO,ISS)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO,ISS)
neural tube closure  (ISO)
positive regulation of cellular response to insulin stimulus  (IMP)
positive regulation of dendrite development  (IMP)
positive regulation of dendritic spine morphogenesis  (IMP)
positive regulation of insulin receptor signaling pathway  (IMP)
positive regulation of mitochondrial fusion  (IMP)
positive regulation of neuron maturation  (IMP)
protein complex oligomerization  (ISO)
response to curcumin  (IEP)
response to electrical stimulus  (IEP)
response to muscle activity  (IEP)
response to nutrient levels  (IEP)
retina development in camera-type eye  (IEP)
visual perception  (ISO,ISS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy. Alavi MV, etal., Brain. 2007 Apr;130(Pt 4):1029-42. Epub 2007 Feb 21.
2. Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics. Aparicio-Trejo OE, etal., Biofactors. 2016 Nov 1. doi: 10.1002/biof.1338.
3. A major marker for normal tension glaucoma: association with polymorphisms in the OPA1 gene. Aung T, etal., Hum Genet. 2002 Jan;110(1):52-6. Epub 2001 Nov 23.
4. Investigating the association between OPA1 polymorphisms and glaucoma: comparison between normal tension and high tension primary open angle glaucoma. Aung T, etal., Hum Genet. 2002 May;110(5):513-4. Epub 2002 Apr 10.
5. OPA1 loss of function affects in vitro neuronal maturation. Bertholet AM, etal., Brain. 2013 May;136(Pt 5):1518-33. doi: 10.1093/brain/awt060. Epub 2013 Mar 29.
6. OPA1, the disease gene for optic atrophy type Kjer, is expressed in the inner ear. Bette S, etal., Histochem Cell Biol. 2007 Nov;128(5):421-30. Epub 2007 Sep 8.
7. In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring. Borengasser SJ, etal., Physiol Genomics. 2014 Dec 1;46(23):841-50. doi: 10.1152/physiolgenomics.00059.2014. Epub 2014 Oct 21.
8. Down-regulation of OPA1 in patients with primary open angle glaucoma. Bosley TM, etal., Mol Vis. 2011 Apr 27;17:1074-9.
9. Mitochondrial OPA1, apoptosis, and heart failure. Chen L, etal., Cardiovasc Res. 2009 Oct 1;84(1):91-9. doi: 10.1093/cvr/cvp181. Epub 2009 Jun 3.
10. OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. Chen L, etal., J Am Heart Assoc. 2012 Oct;1(5):e003012. doi: 10.1161/JAHA.112.003012. Epub 2012 Oct 25.
11. Mutation survey of the optic atrophy 1 gene in 193 Chinese families with suspected hereditary optic neuropathy. Chen Y, etal., Mol Vis. 2013;19:292-302. Epub 2013 Feb 6.
12. Autosomal dominant optic atrophy: penetrance and expressivity in patients with OPA1 mutations. Cohn AC, etal., Am J Ophthalmol. 2007 Apr;143(4):656-62. Epub 2007 Feb 15.
13. Mitochondria dynamism: of shape, transport and cell migration. da Silva AF, etal., Cell Mol Life Sci. 2014 Jun;71(12):2313-24. doi: 10.1007/s00018-014-1557-8. Epub 2014 Jan 18.
14. Inducible nitric oxide synthase-mediated alteration of mitochondrial OPA1 expression in ocular hypertensive rats. Dai Y, etal., Invest Ophthalmol Vis Sci. 2011 Apr 16;52(5):2468-76. doi: 10.1167/iovs.10-5873.
15. Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function. Davies VJ, etal., Hum Mol Genet. 2007 Jun 1;16(11):1307-18. Epub 2007 Apr 11.
16. Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake. del Campo A, etal., Am J Physiol Endocrinol Metab. 2014 Jan 1;306(1):E1-E13. doi: 10.1152/ajpendo.00146.2013. Epub 2013 Oct 1.
17. Solving a 50 year mystery of a missing OPA1 mutation: more insights from the first family diagnosed with autosomal dominant optic atrophy. Fuhrmann N, etal., Mol Neurodegener. 2010 Jun 14;5:25. doi: 10.1186/1750-1326-5-25.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
20. PM2.5-Induced Oxidative Stress and Mitochondrial Damage in the Nasal Mucosa of Rats. Guo Z, etal., Int J Environ Res Public Health. 2017 Jan 29;14(2). pii: E134. doi: 10.3390/ijerph14020134.
21. OPA1 mutations and mitochondrial DNA haplotypes in autosomal dominant optic atrophy. Han J, etal., Genet Med. 2006 Apr;8(4):217-25.
22. Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity. Hu X, etal., Mol Vis. 2017 Jul 19;23:447-456. eCollection 2017.
23. Regulation of mitochondrial morphology through proteolytic cleavage of OPA1. Ishihara N, etal., EMBO J. 2006 Jul 12;25(13):2966-77. Epub 2006 Jun 15.
24. Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition. Javadov S, etal., Basic Res Cardiol. 2011 Jan;106(1):99-109. doi: 10.1007/s00395-010-0122-3. Epub 2010 Oct 1.
25. Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina. Ju WK, etal., Invest Ophthalmol Vis Sci. 2009 Feb;50(2):707-16. doi: 10.1167/iovs.08-2499. Epub 2008 Oct 20.
26. Glutamate receptor activation triggers OPA1 release and induces apoptotic cell death in ischemic rat retina. Ju WK, etal., Mol Vis. 2008;14:2629-38. Epub 2008 Dec 31.
27. Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells. Ju WK, etal., Mol Vis. 2009;15:120-34. Epub 2009 Jan 19.
28. Increased optic atrophy type 1 expression protects retinal ganglion cells in a mouse model of glaucoma. Ju WK, etal., Mol Vis. 2010 Jul 15;16:1331-42.
29. Expression of the Opa1 mitochondrial protein in retinal ganglion cells: its downregulation causes aggregation of the mitochondrial network. Kamei S, etal., Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4288-94.
30. Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1. Kar R, etal., Biochem Biophys Res Commun. 2010 Sep 3;399(4):548-54. doi: 10.1016/j.bbrc.2010.07.108. Epub 2010 Aug 1.
31. Effect of electrical stimulation-induced resistance exercise on mitochondrial fission and fusion proteins in rat skeletal muscle. Kitaoka Y, etal., Appl Physiol Nutr Metab. 2015 Nov;40(11):1137-42. doi: 10.1139/apnm-2015-0184. Epub 2015 Jul 14.
32. Effect of ambient PM(2.5) on lung mitochondrial damage and fusion/fission gene expression in rats. Li R, etal., Chem Res Toxicol. 2015 Mar 16;28(3):408-18. doi: 10.1021/tx5003723. Epub 2015 Jan 16.
33. Mitochondrial damage: an important mechanism of ambient PM2.5 exposure-induced acute heart injury in rats. Li R, etal., J Hazard Mater. 2015 Apr 28;287:392-401. doi: 10.1016/j.jhazmat.2015.02.006. Epub 2015 Feb 4.
34. Identification of two novel OPA1 mutations in Chinese families with autosomal dominant optic atrophy. Li Y, etal., Mol Vis. 2008;14:2451-7. Epub 2008 Dec 29.
35. High-lard and high-fish-oil diets differ in their effects on function and dynamic behaviour of rat hepatic mitochondria. Lionetti L, etal., PLoS One. 2014 Mar 24;9(3):e92753. doi: 10.1371/journal.pone.0092753. eCollection 2014.
36. Dynamic changes of mitochondrial fusion and fission proteins after transient cerebral ischemia in mice. Liu W, etal., J Neurosci Res. 2012 Jun;90(6):1183-9. doi: 10.1002/jnr.23016. Epub 2012 Feb 16.
37. No association between OPA1 polymorphisms and primary open-angle glaucoma in three different populations. Liu Y, etal., Mol Vis. 2007 Nov 26;13:2137-41.
38. Mitochondrial dysfunction is associated with a pro-apoptotic cellular environment in senescent cardiac muscle. Ljubicic V, etal., Mech Ageing Dev. 2010 Feb;131(2):79-88. doi: 10.1016/j.mad.2009.12.004. Epub 2009 Dec 29.
39. The OPA1 gene polymorphism is associated with normal tension and high tension glaucoma. Mabuchi F, etal., Am J Ophthalmol. 2007 Jan;143(1):125-130. Epub 2006 Oct 23.
40. Exercise and Doxorubicin Treatment Modulate Cardiac Mitochondrial Quality Control Signaling. Marques-Aleixo I, etal., Cardiovasc Toxicol. 2017 May 23. doi: 10.1007/s12012-017-9412-4.
41. Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3 dependent manner. Meng G, etal., Br J Pharmacol. 2017 May 15. doi: 10.1111/bph.13861.
42. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
43. Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration. Misko AL, etal., J Neurosci. 2012 Mar 21;32(12):4145-55. doi: 10.1523/JNEUROSCI.6338-11.2012.
44. Novel mutations in the OPA1 gene and associated clinical features in Japanese patients with optic atrophy. Nakamura M, etal., Ophthalmology. 2006 Mar;113(3):483-488.e1.
45. Adaptive plasticity of autophagic proteins to denervation in aging skeletal muscle. O'Leary MF, etal., Am J Physiol Cell Physiol. 2013 Mar 1;304(5):C422-30. doi: 10.1152/ajpcell.00240.2012. Epub 2012 Dec 5.
46. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
47. The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery. Palmer CS, etal., Cell Signal. 2011 Oct;23(10):1534-45. doi: 10.1016/j.cellsig.2011.05.021. Epub 2011 Jun 13.
48. OPA1, the disease gene for autosomal dominant optic atrophy, is specifically expressed in ganglion cells and intrinsic neurons of the retina. Pesch UE, etal., Invest Ophthalmol Vis Sci 2004 Nov;45(11):4217-25.
49. Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload. Piquereau J, etal., Cardiovasc Res. 2012 Jun 1;94(3):408-17. doi: 10.1093/cvr/cvs117. Epub 2012 Mar 8.
50. Novel OPA1 mutations identified in Japanese pedigrees with optic atrophy. Qin M, etal., Mol Vis. 2006 May 12;12:485-91.
51. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
52. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
53. Comprehensive gene review and curation RGD comprehensive gene curation
54. Perturbation in mitochondrial network dynamics and in complex I dependent cellular respiration in schizophrenia. Rosenfeld M, etal., Biol Psychiatry. 2011 May 15;69(10):980-8. doi: 10.1016/j.biopsych.2011.01.010. Epub 2011 Mar 11.
55. Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch. Schlattner U, etal., J Biol Chem. 2013 Jan 4;288(1):111-21. doi: 10.1074/jbc.M112.408633. Epub 2012 Nov 13.
56. Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat. Tang Y, etal., Cardiovasc Pathol. 2013 Nov 14. pii: S1054-8807(13)00200-7. doi: 10.1016/j.carpath.2013.11.002.
57. Impaired balance of mitochondrial fission and fusion in Alzheimer's disease. Wang X, etal., J Neurosci. 2009 Jul 15;29(28):9090-103. doi: 10.1523/JNEUROSCI.1357-09.2009.
58. Vagal nerve stimulation improves mitochondrial dynamics via an M3 receptor/CaMKKß/AMPK pathway in isoproterenol-induced myocardial ischaemia. Xue RQ, etal., J Cell Mol Med. 2017 Jan;21(1):58-71. doi: 10.1111/jcmm.12938. Epub 2016 Aug 5.
59. Evaluation of the association between OPA1 polymorphisms and primary open-angle glaucoma in Barbados families. Yao W, etal., Mol Vis. 2006 Jun 12;12:649-54.
60. Novel mutations of the OPA1 gene in Chinese dominant optic atrophy. Yen MY, etal., Ophthalmology. 2010 Feb;117(2):392-6.e1. doi: 10.1016/j.ophtha.2009.07.019. Epub 2009 Dec 6.
61. High glucose concentration abrogates sevoflurane post-conditioning cardioprotection by advancing mitochondrial fission but dynamin-related protein 1 inhibitor restores these effects. Yu J, etal., Acta Physiol (Oxf). 2016 Sep 29. doi: 10.1111/apha.12812.
62. Sevoflurane postconditioning attenuates cardiomyocyte hypoxia/reoxygenation injury via restoring mitochondrial morphology. Yu J, etal., PeerJ. 2016 Nov 3;4:e2659. eCollection 2016.
63. The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Yu W, etal., Hum Mol Genet. 2011 Aug 15;20(16):3227-40. doi: 10.1093/hmg/ddr235. Epub 2011 May 25.
64. Exercise pretreatment promotes mitochondrial dynamic protein OPA1 expression after cerebral ischemia in rats. Zhang L, etal., Int J Mol Sci. 2014 Mar 13;15(3):4453-63. doi: 10.3390/ijms15034453.
Additional References at PubMed
PMID:11017080   PMID:11847212   PMID:12477932   PMID:12504110   PMID:12509422   PMID:12865426   PMID:14651853   PMID:15489334   PMID:15755804   PMID:15899901   PMID:15912498   PMID:16839884  
PMID:17008324   PMID:17035996   PMID:17545159   PMID:18158317   PMID:18614015   PMID:19046944   PMID:19946888   PMID:20038678   PMID:20185555   PMID:20436456   PMID:21149567   PMID:23220553  
PMID:23453807   PMID:23494933   PMID:24632637   PMID:26316108   PMID:26530815   PMID:27667664   PMID:27890624   PMID:28746876   PMID:29476059   PMID:30988455   PMID:31505169   PMID:31519870  
PMID:32901846   PMID:33119220   PMID:33383158  


Genomics

Comparative Map Data
Opa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21171,108,100 - 71,185,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1171,109,873 - 71,185,109 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1179,954,641 - 80,028,866 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01172,589,604 - 72,663,829 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01171,643,710 - 71,718,085 (-)NCBIRnor_WKY
Rnor_6.01174,717,600 - 74,793,902 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,720,254 - 74,793,803 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,761,813 - 77,840,630 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41173,005,470 - 73,058,136 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11173,063,058 - 73,115,780 (-)NCBI
Celera1170,077,956 - 70,151,932 (-)NCBICelera
Cytogenetic Map11q22NCBI
OPA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383193,593,208 - 193,697,811 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3193,593,144 - 193,697,811 (+)EnsemblGRCh38hg38GRCh38
GRCh373193,310,997 - 193,415,600 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363194,793,806 - 194,898,009 (+)NCBINCBI36Build 36hg18NCBI36
Build 343194,793,813 - 194,898,017NCBI
Celera3191,726,124 - 191,830,778 (+)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3190,698,074 - 190,803,338 (+)NCBIHuRef
CHM1_13193,273,732 - 193,378,486 (+)NCBICHM1_1
T2T-CHM13v2.03196,288,807 - 196,394,453 (+)NCBIT2T-CHM13v2.0
Opa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391629,398,099 - 29,481,924 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1629,398,152 - 29,473,702 (+)EnsemblGRCm39 Ensembl
GRCm381629,579,281 - 29,663,127 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1629,579,334 - 29,654,884 (+)EnsemblGRCm38mm10GRCm38
MGSCv371629,579,428 - 29,652,576 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361629,499,089 - 29,572,237 (+)NCBIMGSCv36mm8
Celera1630,084,446 - 30,156,121 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1620.65NCBI
Opa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542014,923,575 - 15,007,081 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542014,927,490 - 15,007,082 (-)NCBIChiLan1.0ChiLan1.0
OPA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13201,207,609 - 201,312,358 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3201,207,607 - 201,312,358 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03190,890,242 - 190,995,133 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
OPA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12352,068,123 - 52,154,410 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2352,068,118 - 52,151,593 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2351,880,860 - 51,967,154 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02352,711,633 - 52,798,264 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2352,711,607 - 52,797,401 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12352,292,969 - 52,379,474 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02352,346,071 - 52,432,352 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02352,630,584 - 52,717,188 (+)NCBIUU_Cfam_GSD_1.0
Opa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602123,136,008 - 123,222,290 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367111,027,531 - 1,113,796 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13130,624,796 - 130,719,083 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113130,624,771 - 130,718,345 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213140,148,025 - 140,230,316 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OPA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11587,679,656 - 87,778,767 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1587,679,077 - 87,779,102 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604161,348,078 - 61,447,152 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Opa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473063,911,066 - 63,995,596 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473063,911,066 - 63,994,886 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
D11Rat105  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21171,134,896 - 71,135,104 (+)MAPPERmRatBN7.2
Rnor_6.01174,743,188 - 74,743,395NCBIRnor6.0
Rnor_5.01177,789,916 - 77,790,123UniSTSRnor5.0
RGSC_v3.41173,007,964 - 73,008,171UniSTSRGSC3.4
RGSC_v3.41173,007,964 - 73,008,171RGDRGSC3.4
RGSC_v3.11173,065,553 - 73,065,760RGD
Celera1170,101,928 - 70,102,133UniSTS
RH 3.4 Map11572.6UniSTS
RH 3.4 Map11572.6RGD
RH 2.0 Map11123.0RGD
SHRSP x BN Map1134.4799RGD
Cytogenetic Map11q22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:653
Count of miRNA genes:181
Interacting mature miRNAs:210
Transcripts:ENSRNOT00000002338, ENSRNOT00000002343, ENSRNOT00000063999
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY333988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY510274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY660011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY660012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY683458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U93197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000002338   ⟹   ENSRNOP00000002338
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1171,132,335 - 71,180,355 (-)Ensembl
Rnor_6.0 Ensembl1174,722,819 - 74,793,673 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000002343   ⟹   ENSRNOP00000002343
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1171,109,873 - 71,185,109 (-)Ensembl
Rnor_6.0 Ensembl1174,720,254 - 74,793,803 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104752   ⟹   ENSRNOP00000086026
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1171,109,873 - 71,185,109 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111984   ⟹   ENSRNOP00000079139
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1171,109,873 - 71,185,109 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117359   ⟹   ENSRNOP00000084440
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1171,109,873 - 71,185,109 (-)Ensembl
RefSeq Acc Id: NM_133585   ⟹   NP_598269
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21171,110,751 - 71,185,071 (-)NCBI
Rnor_6.01174,720,246 - 74,793,803 (-)NCBI
Rnor_5.01177,761,813 - 77,840,630 (-)NCBI
RGSC_v3.41173,005,470 - 73,058,136 (-)RGD
Celera1170,077,956 - 70,151,932 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248497   ⟹   XP_006248559
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21171,108,100 - 71,185,170 (-)NCBI
Rnor_6.01174,717,600 - 74,793,902 (-)NCBI
Rnor_5.01177,761,813 - 77,840,630 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248498   ⟹   XP_006248560
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21171,108,100 - 71,185,170 (-)NCBI
Rnor_6.01174,717,600 - 74,793,902 (-)NCBI
Rnor_5.01177,761,813 - 77,840,630 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248499   ⟹   XP_006248561
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21171,108,100 - 71,185,170 (-)NCBI
Rnor_6.01174,717,600 - 74,793,902 (-)NCBI
Rnor_5.01177,761,813 - 77,840,630 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597865   ⟹   XP_017453354
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21171,108,100 - 71,185,170 (-)NCBI
Rnor_6.01174,717,600 - 74,793,902 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597866   ⟹   XP_017453355
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21171,108,100 - 71,185,170 (-)NCBI
Rnor_6.01174,717,600 - 74,793,902 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598269   ⟸   NM_133585
- Peptide Label: precursor
- UniProtKB: Q6R611 (UniProtKB/Swiss-Prot),   Q2TA68 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006248560   ⟸   XM_006248498
- Peptide Label: isoform X2
- UniProtKB: Q2TA68 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006248561   ⟸   XM_006248499
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006248559   ⟸   XM_006248497
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017453355   ⟸   XM_017597866
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017453354   ⟸   XM_017597865
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000002343   ⟸   ENSRNOT00000002343
RefSeq Acc Id: ENSRNOP00000002338   ⟸   ENSRNOT00000002338
RefSeq Acc Id: ENSRNOP00000079139   ⟸   ENSRNOT00000111984
RefSeq Acc Id: ENSRNOP00000084440   ⟸   ENSRNOT00000117359
RefSeq Acc Id: ENSRNOP00000086026   ⟸   ENSRNOT00000104752
Protein Domains
Dynamin-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2TA68-F1-model_v2 AlphaFold Q2TA68 1-960 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698231
Promoter ID:EPDNEW_R8755
Type:multiple initiation site
Name:Opa1_1
Description:OPA1, mitochondrial dynamin like GTPase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01174,793,820 - 74,793,880EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708423 AgrOrtholog
BioCyc Gene G2FUF-20984 BioCyc
Ensembl Genes ENSRNOG00000001717 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002338 ENTREZGENE
  ENSRNOP00000002338.8 UniProtKB/TrEMBL
  ENSRNOP00000002343 ENTREZGENE
  ENSRNOP00000002343.7 UniProtKB/TrEMBL
  ENSRNOP00000079139 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000084440 ENTREZGENE
  ENSRNOP00000084440.1 UniProtKB/TrEMBL
  ENSRNOP00000086026 ENTREZGENE
  ENSRNOP00000086026.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002338 ENTREZGENE
  ENSRNOT00000002338.9 UniProtKB/TrEMBL
  ENSRNOT00000002343 ENTREZGENE
  ENSRNOT00000002343.8 UniProtKB/TrEMBL
  ENSRNOT00000104752 ENTREZGENE
  ENSRNOT00000104752.1 UniProtKB/TrEMBL
  ENSRNOT00000111984 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000117359 ENTREZGENE
  ENSRNOT00000117359.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7324017 IMAGE-MGC_LOAD
InterPro Dynamin UniProtKB/TrEMBL
  Dynamin_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dynamin_SF UniProtKB/Swiss-Prot
  G_DYNAMIN_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Opa1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OPA1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171116 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124921 IMAGE-MGC_LOAD
NCBI Gene 171116 ENTREZGENE
PANTHER PTHR11566 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11566:SF67 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dynamin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OPA1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Opa1 PhenoGen
PRINTS DYNAMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_DYNAMIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DYNc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZZK0_RAT UniProtKB/TrEMBL
  A0A8I6A517_RAT UniProtKB/TrEMBL
  A0A8L2PZL8_RAT UniProtKB/TrEMBL
  A0A8L2Q0I8_RAT UniProtKB/TrEMBL
  OPA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6R611 ENTREZGENE
UniProt Secondary O08681 UniProtKB/Swiss-Prot
  Q5MPP1 UniProtKB/Swiss-Prot
  Q5MPP2 UniProtKB/Swiss-Prot
  Q5QJE9 UniProtKB/Swiss-Prot
  Q6B435 UniProtKB/Swiss-Prot
  Q6R611 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Opa1  OPA1, mitochondrial dynamin like GTPase  Opa1  optic atrophy 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-22 Opa1  optic atrophy 1  Opa1  optic atrophy 1 homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Opa1  optic atrophy 1 homolog (human)  LOC171116  RN protein  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog causes autosomal dominant optic atrophy 1547836
gene_expression expressed in retinal ganglion cells, starburst amacrine cells and horizontal cells of the inner retina 1547836