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Gene: Opa1 (OPA1, mitochondrial dynamin like GTPase) Rattus norvegicus
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Symbol: Opa1
Name: OPA1, mitochondrial dynamin like GTPase
Description: Exhibits kinase binding activity. Involved in several processes, including cellular response to L-glutamate; positive regulation of neuron differentiation; and sensory organ development. Localizes to the cytosol and extrinsic component of mitochondrial inner membrane. Colocalizes with the mitochondrion. Used to study transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease; fatty liver disease; ocular hypertension; and rhinitis. Human ortholog(s) of this gene implicated in dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; and optic atrophy. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase); PARTICIPATES IN mitochondria fusion pathway; INTERACTS WITH 2,6-dinitrotoluene; 4-DAMP(1+); actinomycin D.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dynamin-like 120 kDa protein, mitochondrial; LOC171116; MGC124921; mitochondrial OPA1; optic atrophy 1; optic atrophy 1 (autosomal dominant); optic atrophy 1 homolog; optic atrophy 1 homolog (human); optic atrophy 1-like protein; optic atrophy protein 1 homolog; RN protein
Orthologs:
Homo sapiens (human) : OPA1 (OPA1 mitochondrial dynamin like GTPase)  HGNC  Alliance
Mus musculus (house mouse) : Opa1 (OPA1, mitochondrial dynamin like GTPase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Opa1 (OPA1 mitochondrial dynamin like GTPase)
Pan paniscus (bonobo/pygmy chimpanzee) : OPA1 (OPA1 mitochondrial dynamin like GTPase)
Canis lupus familiaris (dog) : OPA1 (OPA1 mitochondrial dynamin like GTPase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Opa1 (OPA1 mitochondrial dynamin like GTPase)
Sus scrofa (pig) : OPA1 (OPA1 mitochondrial dynamin like GTPase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01174,717,600 - 74,793,902 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1174,720,254 - 74,793,803 (-)Ensembl
Rnor_5.01177,761,813 - 77,840,630 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41173,005,470 - 73,058,136 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11173,063,058 - 73,115,780 (-)NCBI
Celera1170,077,956 - 70,151,932 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Opa1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 708423
Created: 2003-09-23
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.