Gene: Opa1 (OPA1, mitochondrial dynamin like GTPase) Rattus norvegicus
Analyze
Symbol:
Opa1
Name:
OPA1, mitochondrial dynamin like GTPase
RGD ID:
708423
Description:
Exhibits kinase binding activity. Involved in several processes, including mitochondrion organization; positive regulation of neuron differentiation; and sensory organ development. Localizes to cytosol and extrinsic component of mitochondrial inner membrane. Colocalizes with mitochondrion. Used to study transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease; fatty liver disease; ocular hypertension; and rhinitis. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase); PARTICIPATES IN mitochondria fusion pathway; INTERACTS WITH 2,6-dinitrotoluene; 4-DAMP(1+); actinomycin D.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
dynamin-like 120 kDa protein, mitochondrial; LOC171116; MGC124921; mitochondrial OPA1; optic atrophy 1; optic atrophy 1 (autosomal dominant); optic atrophy 1 homolog; optic atrophy 1 homolog (human); optic atrophy 1-like protein; optic atrophy protein 1 homolog; RN protein
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
OPA1 (OPA1 mitochondrial dynamin like GTPase) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):
Opa1 (OPA1, mitochondrial dynamin like GTPase) HGNC
NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Opa1 (OPA1 mitochondrial dynamin like GTPase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
OPA1 (OPA1 mitochondrial dynamin like GTPase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
OPA1 (OPA1 mitochondrial dynamin like GTPase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Opa1 (OPA1 mitochondrial dynamin like GTPase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
OPA1 (OPA1 mitochondrial dynamin like GTPase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
OPA1 (OPA1 mitochondrial dynamin like GTPase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Opa1 (OPA1 mitochondrial dynamin like GTPase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
OPA1 (OPA1 mitochondrial dynamin like GTPase)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER)
Mus musculus (house mouse):
Opa1 (OPA1, mitochondrial dynamin like GTPase)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER)
Saccharomyces cerevisiae (baker's yeast):
MGM1
Alliance
DIOPT (Ensembl Compara|Hieranoid|PANTHER)
Drosophila melanogaster (fruit fly):
Opa1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER)
Caenorhabditis elegans (roundworm):
eat-3
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: suggests misassembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 11 74,717,600 - 74,793,902 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 11 74,720,254 - 74,793,803 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 11 77,761,813 - 77,840,630 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 11 73,005,470 - 73,058,136 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 11 73,063,058 - 73,115,780 (-) NCBI Celera 11 70,077,956 - 70,151,932 (-) NCBI Celera Cytogenetic Map 11 q22 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
Acute Lung Injury IEP 12437080 mRNA, protein:altered expression:lung (rat) RGD Alzheimer's disease ISO RGD:1344166 7800727 protein:decreased expression:brain RGD Cardiomegaly IEP 7800726 associated with Hypertension RGD Cardiomegaly treatment ISO RGD:1551416 12910714 RGD Cardiomegaly ISO RGD:1551416 7800697 RGD cardiomyopathy onset ISO RGD:1551416 7800701 RGD chronic kidney disease treatment IEP 12738369 RGD congestive heart failure IEP 7800717 protein:decreased expression:heart RGD fatty liver disease IEP 12453042 protein:increased expression:liver (rat) RGD glaucoma treatment ISO RGD:1551416 7800698 ; 7800720 RGD Heart Injuries IEP 12437078 mRNA, protein:increased expression:heart (rat) RGD hypertension IEP 7800726 protein:increased expression:heart left ventricle (rat) RGD myocardial infarction treatment IEP 12738232 RGD Myocardial Ischemia treatment IEP 12910831 RGD Normal Tension Glaucoma ISO RGD:1344166 7800687 DNA:SNPs, haplotype:intron:IVS8+4C>T, IVS8+32T>C (human) RGD Normal Tension Glaucoma ISO RGD:1344166 7800712 DNA:splice-site mutations, deletion, missense mutation:introns, exon:multiple RGD Normal Tension Glaucoma ISO RGD:1344166 7800710 DNA:polymorphism:intron:IVS8+4C>T (human) RGD Normal Tension Glaucoma ISO RGD:1344166 7800685 DNA:polymorphism:intron:IVS8+32T>C (human) RGD ocular hypertension IEP 7800684 mRNA, protein:increased expression:retina RGD optic atrophy ISO RGD:1344166 7800714 DNA:splice-site mutation, insertion:intron:c.579_580insTT, c.871-1G>T (human) RGD optic atrophy 1 ISO RGD:1551416 7800686 DNA:nonsense mutation:exon:p.Q285X (mouse) RGD optic atrophy 1 ISO RGD:1344166 7800708 DNA:insertions, deletions, missense mutations, nonsense mutation: :multiple RGD optic atrophy 1 ISO RGD:1344166 7800706 DNA:splice-site mutation, nonsense mutation:intron, exon:IVS9-2A>G, c.2197C>T (p.R733X) (human) RGD optic atrophy 1 ISO RGD:1344166 7800709 DNA:duplication:exons, introns:g.194832822_194840568dup (human) RGD optic atrophy 1 ISO RGD:1551416 7800716 DNA:splice-site mutation:intron:c.1065+5G>A (mouse) RGD optic atrophy 1 ISO RGD:1344166 7800715 DNA:mutations:multiple RGD optic atrophy 1 ISO RGD:1344166 7800699 DNA:SNPs, deletions:exons:multiple RGD optic atrophy 1 ISO RGD:1344166 7800704 DNA:deletions, SNPs, insertion/deletion:exons, intron, cds:multiple RGD primary open angle glaucoma no_association ISO RGD:1344166 7800685 DNA:polymorphism:intron:IVS8+4C>T (human) RGD primary open angle glaucoma ISO RGD:1344166 7800718 mRNA:decreased expression:blood, leukocyte RGD primary open angle glaucoma no_association ISO RGD:1344166 7800721 DNA:SNPs: :rs166850, rs10451941 (human) RGD primary open angle glaucoma no_association ISO RGD:1344166 7800713 DNA:SNPs:exons, introns:multiple RGD Retina Reperfusion Injury IEP 13208943 protein:increased expression:retina, cytosol (rat) RGD rhinitis IEP 13204839 mRNA, protein:increased expression:nasal cavity mucosa (rat) RGD Sarcopenia IEP 12738219 protein:increased expression:extensor digitorum longus (rat) RGD schizophrenia ISO RGD:1344166 13204843 protein:decreased expression: prefrontal cortex (human) RGD transient cerebral ischemia treatment IDA 13208946 RGD transient cerebral ischemia ISO RGD:1551416 7800722 protein:altered expression:brain RGD
Imported Annotations - ClinVar
Behr syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by term: OPTIC ATROPHY, INFANTILE HEREDITARY, WITH NEUROLOGIC ABNORMALITIES ClinVar PMID:25741868 Behr syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by term: OPTIC ATROPHY, INFANTILE HEREDITARY, WITH NEUROLOGIC ABNORMALITIES ClinVar PMID:25146916 Behr syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic atrophy in early childhood, associated with ataxia, spasticity, mental retardation, and posterior column sensory loss ClinVar PMID:17722006 more ... Behr syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by term: OPTIC ATROPHY, INFANTILE HEREDITARY, WITH NEUROLOGIC ABNORMALITIES ClinVar PMID:11017079 more ... Behr syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by term: OPTIC ATROPHY, INFANTILE HEREDITARY, WITH NEUROLOGIC ABNORMALITIES ClinVar PMID:25012220 cataract ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Lens opacity ClinVar PMID:30311386 cerebellar ataxia ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Cerebellar ataxia ClinVar PMID:30311386 Developmental Disabilities ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Global developmental delay ClinVar PMID:30311386 dominant optic atrophy plus syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Autosomal dominant optic atrophy plus syndrome ClinVar PMID:29389947 dominant optic atrophy plus syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Autosomal dominant optic atrophy plus syndrome ClinVar PMID:19303950 more ... dominant optic atrophy plus syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by term: OPTIC ATROPHY WITH OR WITHOUT DEAFNESS, OPHTHALMOPLEGIA, MYOPATHY, ATAXIA, AND NEUROPATHY ClinVar PMID:20157015 more ... dominant optic atrophy plus syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by term: OPTIC ATROPHY WITH OR WITHOUT DEAFNESS, OPHTHALMOPLEGIA, MYOPATHY, ATAXIA, AND NEUROPATHY ClinVar PMID:12566046 more ... dominant optic atrophy plus syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by term: OPTIC ATROPHY WITH OR WITHOUT DEAFNESS, OPHTHALMOPLEGIA, MYOPATHY, ATAXIA, AND NEUROPATHY ClinVar PMID:17722006 more ... dominant optic atrophy plus syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by term: OPTIC ATROPHY WITH OR WITHOUT DEAFNESS, OPHTHALMOPLEGIA, MYOPATHY, ATAXIA, AND NEUROPATHY ClinVar PMID:18065439 more ... dominant optic atrophy plus syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by term: OPTIC ATROPHY WITH OR WITHOUT DEAFNESS, OPHTHALMOPLEGIA, MYOPATHY, ATAXIA, AND NEUROPATHY ClinVar PMID:19029523 , PMID:28812649 dominant optic atrophy plus syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by term: OPTIC ATROPHY WITH OR WITHOUT DEAFNESS, OPHTHALMOPLEGIA, MYOPATHY, ATAXIA, AND NEUROPATHY ClinVar PMID:25741868 dominant optic atrophy plus syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by OMIM:125250 ClinVar PMID:21112924 dominant optic atrophy plus syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by OMIM:125250 ClinVar PMID:18195150 dominant optic atrophy plus syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by OMIM:125250 ClinVar PMID:17188070 dominant optic atrophy plus syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by OMIM:125250 ClinVar PMID:18158317 dominant optic atrophy plus syndrome ISO RGD:1344166 8554872 ClinVar Annotator: match by OMIM:125250 ClinVar PMID:21646330 fundus dystrophy ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Retinal dystrophy ClinVar PMID:12036970 more ... fundus dystrophy ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Retinal dystrophy ClinVar PMID:25012220 fundus dystrophy ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Retinal dystrophy ClinVar PMID:11017079 more ... fundus dystrophy ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Retinal dystrophy ClinVar genetic disease ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:11440989 more ... genetic disease ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:12566046 more ... isolated elevated serum creatine phosphokinase levels ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Elevated serum creatine phosphokinase ClinVar PMID:19303950 more ... macular retinal edema ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Macular oedema ClinVar PMID:30311386 mitochondrial DNA depletion syndrome 14 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Mitochondrial DNA depletion syndrome 14 (cardioencephalomyopathic type) ClinVar PMID:26561570 mitochondrial DNA depletion syndrome 14 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Mitochondrial DNA depletion syndrome 14 (cardioencephalomyopathic type) ClinVar PMID:25741868 mitochondrial metabolism disease ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Mitochondrial diseases ClinVar PMID:19029523 , PMID:28812649 mitochondrial metabolism disease ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Mitochondrial diseases ClinVar PMID:12566046 more ... mitochondrial metabolism disease ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Mitochondrial diseases ClinVar PMID:11017079 more ... mitochondrial metabolism disease ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Mitochondrial diseases ClinVar PMID:28812649 mitochondrial metabolism disease ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Mitochondrial diseases ClinVar PMID:18065439 more ... Normal Tension Glaucoma ISO RGD:1344166 8554872 ClinVar Annotator: match by term: GLAUCOMA, NORMAL PRESSURE, SUSCEPTIBILITY TO ClinVar PMID:25741868 optic atrophy ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic atrophy ClinVar optic atrophy ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic atrophy ClinVar PMID:17722006 more ... optic atrophy ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic atrophy ClinVar PMID:30311386 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Dominant hereditary optic atrophy ClinVar PMID:25326637 , PMID:28492532 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Dominant hereditary optic atrophy ClinVar PMID:12842213 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Dominant hereditary optic atrophy ClinVar PMID:18496845 , PMID:19319978 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Dominant hereditary optic atrophy ClinVar PMID:25741868 , PMID:28492532 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Dominant hereditary optic atrophy ClinVar PMID:20417568 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Dominant hereditary optic atrophy ClinVar PMID:26467025 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Dominant hereditary optic atrophy ClinVar PMID:14961560 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Dominant hereditary optic atrophy ClinVar PMID:17722006 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy, Dominant ClinVar PMID:11440988 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Dominant hereditary optic atrophy ClinVar PMID:20157015 , PMID:28492532 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy, Dominant ClinVar PMID:23401657 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy, Dominant ClinVar PMID:28492532 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy, Dominant ClinVar PMID:20801516 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy, Dominant ClinVar PMID:12842213 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy, Dominant ClinVar PMID:16513463 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy Type 1 ClinVar PMID:16617242 , PMID:25741868 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy Type 1 ClinVar PMID:11017079 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy Type 1 ClinVar PMID:11440989 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy Type 1 ClinVar PMID:11017079 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy, Dominant ClinVar PMID:11440988 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy, Dominant ClinVar PMID:25741868 , PMID:26467025 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Dominant hereditary optic atrophy ClinVar PMID:17722006 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy, Dominant ClinVar PMID:11440988 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Dominant hereditary optic atrophy ClinVar PMID:29389947 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy, Dominant ClinVar PMID:25741868 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy, Dominant ClinVar PMID:11440989 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy Type 1 ClinVar PMID:14961560 more ... optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by OMIM:165500 ClinVar PMID:11017080 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by OMIM:165500 ClinVar PMID:17188070 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by OMIM:165500 ClinVar PMID:11017079 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by OMIM:165500 ClinVar PMID:11735024 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by OMIM:165500 ClinVar optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by OMIM:165500 ClinVar PMID:25326637 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by OMIM:165500 ClinVar PMID:23384603 optic atrophy 1 ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Optic Atrophy Type 1 ClinVar PMID:11017079 , PMID:26467025 osteoporosis ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Osteoporosis ClinVar PMID:25741868 paraplegia ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Spastic paraplegia ClinVar PMID:17722006 more ... pathologic nystagmus ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Nystagmus ClinVar PMID:17722006 more ... primary cerebellar degeneration ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Sensorimotor neuropathy ClinVar PMID:17722006 more ... retinitis pigmentosa ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Pigmentary retinopathy ClinVar PMID:30311386 schizophrenia ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Schizophrenia ClinVar PMID:21681106 , PMID:30208311 septooptic dysplasia ISO RGD:1344166 8554872 ClinVar Annotator: match by term: Septo-optic dysplasia sequence ClinVar PMID:19303950 more ...
Imported Annotations - CTD
Normal Tension Glaucoma ISO RGD:1344166 11554173 CTD Direct Evidence: marker/mechanism CTD optic atrophy 1 ISO RGD:1344166 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19900585 , PMID:23409176 osteoarthritis ISO RGD:1344166 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18784066 Ventricular Remodeling ISO RGD:1344166 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20886221 Imported Annotations - MGI
optic atrophy ISS RGD:1551416 13592920 OMIM:165300 more ... MouseDO Imported Annotations - OMIM
Behr syndrome ISO RGD:1344166 7240710 OMIM dominant optic atrophy plus syndrome ISO RGD:1344166 7240710 OMIM mitochondrial DNA depletion syndrome 14 ISO RGD:1344166 7240710 OMIM Normal Tension Glaucoma susceptibility ISO RGD:1344166 7240710 OMIM optic atrophy 1 ISO RGD:1344166 7240710 OMIM
1,2-dimethylhydrazine multiple interactions ISO RGD:1551416 6480464 Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in decreased expression of OPA1 mRNA] CTD PMID:22206623 1,2-dimethylhydrazine decreases expression ISO RGD:1551416 6480464 1, 2-Dimethylhydrazine results in decreased expression of OPA1 mRNA CTD PMID:22206623 17alpha-ethynylestradiol affects expression ISO RGD:1551416 6480464 Ethinyl Estradiol affects the expression of OPA1 mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions ISO RGD:1551416 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of OPA1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:1551416 6480464 Ethinyl Estradiol results in increased expression of OPA1 mRNA CTD PMID:17942748 2,3',4,4',5-Pentachlorobiphenyl increases expression ISO RGD:1551416 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1551416 6480464 Tetrachlorodibenzodioxin results in increased expression of OPA1 mRNA CTD PMID:15328365 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1551416 6480464 Tetrachlorodibenzodioxin affects the expression of OPA1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1551416 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of OPA1 mRNA CTD PMID:17942748 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of OPA1 mRNA CTD PMID:21346803 3,4-methylenedioxymethamphetamine increases expression ISO RGD:1551416 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of OPA1 mRNA CTD PMID:20188158 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1551416 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of OPA1 mRNA CTD PMID:29288687 4,4'-diaminodiphenylmethane increases expression ISO RGD:1551416 6480464 4, 4'-diaminodiphenylmethane results in increased expression of OPA1 mRNA CTD PMID:18648102 4-DAMP(1+) decreases expression EXP 6480464 4-diphenylacetoxy-1, 1-dimethylpiperidinium results in decreased expression of OPA1 protein CTD PMID:27491814 actinomycin D multiple interactions EXP 6480464 Dactinomycin inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of OPA1 protein alternative form] CTD PMID:20678484 aflatoxin B1 increases methylation ISO RGD:1344166 6480464 Aflatoxin B1 results in increased methylation of OPA1 gene CTD PMID:27153756 AICA ribonucleotide multiple interactions EXP 6480464 AICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of OPA1 protein], AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of OPA1 protein] CTD PMID:27792760 aldehydo-D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of OPA1 protein CTD PMID:27684054 , PMID:30144576 aldehydo-D-glucose multiple interactions EXP 6480464 cinnamic acid inhibits the reaction [Glucose results in decreased expression of OPA1 protein], Metformin inhibits the reaction [Glucose results in decreased expression of OPA1 protein] CTD PMID:30144576 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of OPA1 mRNA CTD PMID:16483693 antirheumatic drug increases expression ISO RGD:1344166 6480464 Antirheumatic Agents results in increased expression of OPA1 mRNA CTD PMID:24449571 arsenous acid multiple interactions ISO RGD:1551416 6480464 salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of OPA1 protein] CTD PMID:29867492 arsenous acid multiple interactions EXP 6480464 salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of OPA1 protein] CTD PMID:29867492 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of OPA1 protein CTD PMID:29867492 arsenous acid increases expression ISO RGD:1551416 6480464 Arsenic Trioxide results in increased expression of OPA1 protein CTD PMID:29867492 benzo[a]pyrene decreases expression ISO RGD:1551416 6480464 Benzo(a)pyrene results in decreased expression of OPA1 mRNA CTD PMID:20504355 benzo[a]pyrene affects methylation ISO RGD:1344166 6480464 Benzo(a)pyrene affects the methylation of OPA1 promoter CTD PMID:27901495 benzo[a]pyrene increases expression ISO RGD:1551416 6480464 Benzo(a)pyrene results in increased expression of OPA1 mRNA CTD PMID:21715664 , PMID:22228805 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1344166 6480464 7 more ... CTD PMID:26238291 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of OPA1 mRNA CTD PMID:30816183 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of OPA1 gene CTD PMID:28505145 Brodifacoum increases expression EXP 6480464 bromfenacoum results in increased expression of OPA1 protein CTD PMID:28903499 butanal decreases expression ISO RGD:1344166 6480464 butyraldehyde results in decreased expression of OPA1 mRNA CTD PMID:26079696 cadmium dichloride increases expression ISO RGD:1344166 6480464 Cadmium Chloride results in increased expression of OPA1 mRNA CTD PMID:26472689 carnosic acid increases expression ISO RGD:1344166 6480464 salvin results in increased expression of OPA1 protein CTD PMID:31705926 carnosic acid multiple interactions ISO RGD:1344166 6480464 OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]] more ... CTD PMID:31705926 CCCP decreases expression ISO RGD:1344166 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of OPA1 protein alternative form CTD PMID:28940366 chlorpyrifos decreases expression ISO RGD:1551416 6480464 Chlorpyrifos results in decreased expression of OPA1 mRNA CTD PMID:29156651 cinnamic acid multiple interactions EXP 6480464 cinnamic acid inhibits the reaction [Glucose results in decreased expression of OPA1 protein] CTD PMID:30144576 cisplatin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Cisplatin results in decreased expression of OPA1 protein] CTD PMID:28698153 cisplatin multiple interactions ISO RGD:1551416 6480464 [N-(oxo-5 more ... CTD PMID:31133874 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of OPA1 protein CTD PMID:28698153 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Cisplatin results in decreased expression of OPA1 protein] CTD PMID:28698153 cycloheximide multiple interactions EXP 6480464 Cycloheximide inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of OPA1 protein alternative form] CTD PMID:20678484 D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of OPA1 protein CTD PMID:27684054 , PMID:30144576 D-glucose multiple interactions EXP 6480464 cinnamic acid inhibits the reaction [Glucose results in decreased expression of OPA1 protein], Metformin inhibits the reaction [Glucose results in decreased expression of OPA1 protein] CTD PMID:30144576 dexamethasone multiple interactions ISO RGD:1551416 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of OPA1 mRNA CTD PMID:29288687 diarsenic trioxide increases expression ISO RGD:1551416 6480464 Arsenic Trioxide results in increased expression of OPA1 protein CTD PMID:29867492 diarsenic trioxide multiple interactions EXP 6480464 salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of OPA1 protein] CTD PMID:29867492 diarsenic trioxide multiple interactions ISO RGD:1551416 6480464 salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of OPA1 protein] CTD PMID:29867492 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of OPA1 protein CTD PMID:29867492 dibutyl phthalate decreases expression ISO RGD:1551416 6480464 Dibutyl Phthalate results in decreased expression of OPA1 mRNA CTD PMID:21266533 diclofenac decreases expression ISO RGD:1551416 6480464 Diclofenac results in decreased expression of OPA1 mRNA CTD PMID:26934552 diclofenac decreases expression EXP 6480464 Diclofenac results in decreased expression of OPA1 protein CTD PMID:27792760 diclofenac multiple interactions EXP 6480464 AICA ribonucleotide inhibits the reaction [Diclofenac results in decreased expression of OPA1 protein] CTD PMID:27792760 dieldrin affects expression EXP 6480464 Dieldrin affects the expression of OPA1 mRNA CTD PMID:22546817 dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of OPA1 protein CTD PMID:27684054 dioxygen multiple interactions EXP 6480464 sevoflurane inhibits the reaction [Oxygen deficiency results in decreased expression of OPA1 protein] CTD PMID:27684054 dorsomorphin decreases expression EXP 6480464 dorsomorphin results in decreased expression of OPA1 protein CTD PMID:27491814 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of OPA1 protein CTD PMID:26678157 efavirenz increases expression ISO RGD:1344166 6480464 efavirenz results in increased expression of OPA1 mRNA CTD PMID:28940366 elemental selenium decreases expression ISO RGD:1344166 6480464 Selenium results in decreased expression of OPA1 mRNA CTD PMID:19244175 ethanol affects splicing ISO RGD:1551416 6480464 Ethanol affects the splicing of OPA1 mRNA CTD PMID:30319688 flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of OPA1 mRNA CTD PMID:18035473 folic acid multiple interactions ISO RGD:1551416 6480464 Folic Acid inhibits the reaction [1, 2-Dimethylhydrazine results in decreased expression of OPA1 mRNA] CTD PMID:22206623 formaldehyde decreases expression ISO RGD:1344166 6480464 Formaldehyde results in decreased expression of OPA1 mRNA CTD PMID:23649840 glucose decreases expression EXP 6480464 Glucose results in decreased expression of OPA1 protein CTD PMID:27684054 , PMID:30144576 glucose multiple interactions EXP 6480464 cinnamic acid inhibits the reaction [Glucose results in decreased expression of OPA1 protein], Metformin inhibits the reaction [Glucose results in decreased expression of OPA1 protein] CTD PMID:30144576 hydralazine multiple interactions ISO RGD:1344166 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of OPA1 mRNA CTD PMID:17183730 hydrogen peroxide decreases expression ISO RGD:1344166 6480464 Hydrogen Peroxide results in decreased expression of OPA1 mRNA CTD PMID:30316844 hydrogen peroxide multiple interactions ISO RGD:1344166 6480464 ARNTL protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of OPA1 mRNA]], Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of OPA1 mRNA] CTD PMID:30316844 isoprenaline decreases expression EXP 6480464 Isoproterenol results in decreased expression of OPA1 protein CTD PMID:27491814 lamivudine multiple interactions ISO RGD:1551416 6480464 [Zidovudine co-treated with Lamivudine] results in increased expression of OPA1 mRNA CTD PMID:18313992 Licarin A multiple interactions ISO RGD:1551416 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of OPA1 mRNA CTD PMID:29288687 metformin multiple interactions EXP 6480464 Metformin inhibits the reaction [Glucose results in decreased expression of OPA1 protein] CTD PMID:30144576 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of OPA1 mRNA CTD PMID:30467583 methyl methanesulfonate decreases expression ISO RGD:1344166 6480464 Methyl Methanesulfonate results in decreased expression of OPA1 mRNA CTD PMID:23649840 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of OPA1 protein alternative form], Acetylcysteine inhibits the reaction [15-deoxyprostaglandin J2 results in increased ubiquitination of OPA1 protein] CTD PMID:20678484 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of OPA1 protein alternative form CTD PMID:20678484 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of OPA1 mRNA CTD PMID:20360939 nitrogen dioxide multiple interactions ISO RGD:1551416 6480464 [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of OPA1 protein CTD PMID:27521637 okadaic acid increases expression EXP 6480464 Okadaic Acid results in increased expression of OPA1 protein CTD PMID:26732598 oxidopamine multiple interactions EXP 6480464 isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA] more ... CTD PMID:25129099 oxidopamine multiple interactions ISO RGD:1344166 6480464 OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]] more ... CTD PMID:31705926 oxidopamine decreases expression ISO RGD:1344166 6480464 Oxidopamine results in decreased expression of OPA1 protein CTD PMID:31705926 oxidopamine decreases expression EXP 6480464 Oxidopamine results in decreased expression of OPA1 mRNA CTD PMID:25129099 paracetamol affects expression ISO RGD:1551416 6480464 Acetaminophen affects the expression of OPA1 mRNA CTD PMID:17562736 paracetamol multiple interactions EXP 6480464 AICA ribonucleotide inhibits the reaction [Acetaminophen results in decreased expression of OPA1 protein] CTD PMID:27792760 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of OPA1 protein CTD PMID:27792760 paracetamol decreases expression ISO RGD:1344166 6480464 Acetaminophen results in decreased expression of OPA1 mRNA CTD PMID:21420995 more ... phenethyl caffeate multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of OPA1 mRNA CTD PMID:20360939 piroxicam decreases expression ISO RGD:1344166 6480464 Piroxicam results in decreased expression of OPA1 mRNA CTD PMID:21858171 quercetin 3-O-beta-D-glucofuranoside multiple interactions EXP 6480464 isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA] CTD PMID:25129099 quercetin 3-O-beta-D-glucopyranoside multiple interactions EXP 6480464 isoquercitrin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA] CTD PMID:25129099 resveratrol decreases expression ISO RGD:1344166 6480464 resveratrol results in decreased expression of OPA1 protein CTD PMID:18089832 resveratrol multiple interactions EXP 6480464 Resveratrol inhibits the reaction [Rotenone results in decreased expression of OPA1 mRNA] more ... CTD PMID:26770656 rotenone increases expression ISO RGD:1344166 6480464 Rotenone results in increased expression of OPA1 protein CTD PMID:21223980 rotenone multiple interactions EXP 6480464 resveratrol inhibits the reaction [Rotenone results in decreased expression of OPA1 mRNA] more ... CTD PMID:26770656 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of OPA1 mRNA, Rotenone results in decreased expression of OPA1 protein CTD PMID:26770656 rotenone increases expression EXP 6480464 Rotenone results in increased expression of OPA1 mRNA CTD PMID:19013527 rutin multiple interactions EXP 6480464 Rutin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA] CTD PMID:25129099 Salvianolic acid A multiple interactions EXP 6480464 salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of OPA1 protein] CTD PMID:29867492 Salvianolic acid A multiple interactions ISO RGD:1551416 6480464 salvianolic acid A inhibits the reaction [Arsenic Trioxide results in increased expression of OPA1 protein] CTD PMID:29867492 selenium atom decreases expression ISO RGD:1344166 6480464 Selenium results in decreased expression of OPA1 mRNA CTD PMID:19244175 sevoflurane multiple interactions EXP 6480464 sevoflurane inhibits the reaction [Oxygen deficiency results in decreased expression of OPA1 protein] CTD PMID:27684054 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of OPA1 protein CTD PMID:29459688 sodium fluoride decreases expression ISO RGD:1551416 6480464 Sodium Fluoride results in decreased expression of OPA1 protein CTD PMID:28918527 sulfur dioxide multiple interactions ISO RGD:1551416 6480464 [Particulate Matter co-treated with Sulfur Dioxide co-treated with Nitrogen Dioxide] results in decreased expression of OPA1 protein CTD PMID:27521637 tamoxifen affects expression ISO RGD:1551416 6480464 Tamoxifen affects the expression of OPA1 mRNA CTD PMID:17555576 thapsigargin increases expression ISO RGD:1344166 6480464 Thapsigargin results in increased expression of OPA1 mRNA CTD PMID:28940366 trans-cinnamic acid multiple interactions EXP 6480464 cinnamic acid inhibits the reaction [Glucose results in decreased expression of OPA1 protein] CTD PMID:30144576 tungsten decreases expression ISO RGD:1551416 6480464 Tungsten results in decreased expression of OPA1 mRNA CTD PMID:30912803 valproic acid multiple interactions ISO RGD:1344166 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of OPA1 mRNA CTD PMID:17183730 valproic acid affects expression ISO RGD:1344166 6480464 Valproic Acid affects the expression of OPA1 mRNA CTD PMID:25979313 valproic acid decreases expression ISO RGD:1344166 6480464 Valproic Acid results in decreased expression of OPA1 mRNA CTD PMID:23179753 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of OPA1 mRNA CTD PMID:19015723 zidovudine multiple interactions ISO RGD:1551416 6480464 [Zidovudine co-treated with Lamivudine] results in increased expression of OPA1 mRNA CTD PMID:18313992 zidovudine multiple interactions ISO RGD:1344166 6480464 [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 mRNA, [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 protein CTD PMID:28683400
Biological Process aging IEP 7829729 RGD apoptotic process IEA UniProtKB-KW:KW-0053 1600115 GO_REF:0000043 UniProt GO_REF:0000043 calcium import into the mitochondrion IMP 13208948 RGD cellular response to glucose stimulus IEP 12436725 RGD cellular response to hypoxia IEP 12910766 RGD cellular response to L-glutamate IEP 13432138 RGD cellular senescence ISO RGD:1344166 1624291 (PMID:17545159) RGD PMID:17545159 cellular senescence ISS UniProtKB:O60313 1600115 GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 cochlea development IEP 13208944 RGD dynamin family protein polymerization involved in mitochondrial fission IBA PANTHER:PTN000170085 , UniProtKB:O00429 13792537 PMID:21873635 GO_Central GTP metabolic process ISO RGD:1344166 1624291 (PMID:20185555) RGD PMID:20185555 GTP metabolic process ISS UniProtKB:O60313 1600115 GO_REF:0000024 UniProt GO_REF:0000024 inner mitochondrial membrane organization ISO RGD:1344166 1624291 (PMID:12509422) RGD PMID:12509422 inner mitochondrial membrane organization ISS UniProtKB:O60313 1600115 GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 intracellular distribution of mitochondria IMP 7800727 RGD membrane fusion IBA PANTHER:PTN000170085 more ... 13792537 PMID:21873635 GO_Central membrane tubulation ISO RGD:1344166 1624291 (PMID:20185555) RGD PMID:20185555 membrane tubulation ISS UniProtKB:O60313 1600115 GO_REF:0000024 UniProt GO_REF:0000024 mitochondrial fission IBA FB:FBgn0026479 more ... 13792537 PMID:21873635 GO_Central mitochondrial fusion ISO RGD:1344166 1624291 (PMID:17545159), (PMID:20185555), (PMID:20436456) RGD PMID:17545159 more ... mitochondrial fusion ISO RGD:1551416 1624291 (MGI:4421613 more ... RGD MGI:4421613 more ... mitochondrial fusion ISS UniProtKB:O60313 1600115 GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 mitochondrial genome maintenance ISO RGD:1344166 1624291 (PMID:18158317) RGD PMID:18158317 mitochondrial genome maintenance ISS UniProtKB:O60313 1600115 GO_REF:0000024 UniProt GO_REF:0000024 mitochondrion morphogenesis IMP 7800727 RGD mitochondrion organization ISO RGD:1344166 1624291 (PMID:21149567) RGD PMID:21149567 mitochondrion organization ISO RGD:1551416 1624291 (MGI:4421613, PMID:20038678) RGD MGI:4421613 , PMID:20038678 mitochondrion organization IDA 7800724 RGD negative regulation of apoptotic process ISO RGD:1344166 1624291 (PMID:12509422) RGD PMID:12509422 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO RGD:1344166 1624291 UniProtKB:P58281 (PMID:23453807) RGD PMID:23453807 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO RGD:1551416 1624291 (MGI:5495588, PMID:23453807) RGD MGI:5495588 , PMID:23453807 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISS UniProtKB:P58281 1600115 GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 negative regulation of intrinsic apoptotic signaling pathway ISO RGD:1551416 1624291 (MGI:3692706, PMID:16839884) RGD MGI:3692706 , PMID:16839884 negative regulation of release of cytochrome c from mitochondria ISO RGD:1344166 1624291 (PMID:21149567) RGD PMID:21149567 negative regulation of release of cytochrome c from mitochondria ISO RGD:1551416 1624291 (MGI:3692706, PMID:16839884) RGD MGI:3692706 , PMID:16839884 negative regulation of release of cytochrome c from mitochondria ISS UniProtKB:O60313 1600115 GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 neural tube closure ISO RGD:1551416 1624291 MGI:3578528 (MGI:3577662 , PMID:15755804) RGD MGI:3577662 , PMID:15755804 organelle fission IBA FB:FBgn0026479 more ... 13792537 PMID:21873635 GO_Central positive regulation of cellular response to insulin stimulus IMP 13208948 RGD positive regulation of dendrite development IMP 7800725 RGD positive regulation of dendritic spine morphogenesis IMP 7800727 RGD positive regulation of insulin receptor signaling pathway IMP 13208948 RGD positive regulation of mitochondrial fusion IMP 7829728 RGD positive regulation of neuron maturation IMP 7800725 RGD protein complex oligomerization ISO RGD:1344166 1624291 (PMID:20185555) RGD PMID:20185555 response to curcumin IEP 12738369 RGD response to electrical stimulus IEP 12910850 RGD response to muscle activity IEP 12910705 RGD response to nutrient levels IEP 12880438 high fat diet RGD retina development in camera-type eye IEP 1547836 RGD visual perception ISO RGD:1344166 1624291 (PMID:11017080) RGD PMID:11017080 visual perception ISS UniProtKB:O60313 1600115 GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 Cellular Component cytoplasm IBA CGD:CAL0000188111 more ... 13792537 PMID:21873635 GO_Central cytosol IDA 13208942 RGD cytosol ISO RGD:1344166 1624291 RGD GO_REF:0000052 dendrite ISS UniProtKB:P58281 1600115 GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 dendrite ISO RGD:1551416 1624291 (MGI:2179175, PMID:11847212) RGD MGI:2179175 , PMID:11847212 extrinsic component of mitochondrial inner membrane IDA 7800724 RGD integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000043 UniProt GO_REF:0000043 membrane IBA FB:FBgn0003392 more ... 13792537 PMID:21873635 GO_Central mitochondrial crista ISO RGD:1344166 1624291 (PMID:12504110) RGD PMID:12504110 mitochondrial crista ISS UniProtKB:O60313 1600115 GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 mitochondrial inner membrane ISO RGD:1551416 1624291 (MGI:3692706 more ... RGD MGI:3692706 more ... mitochondrial intermembrane space ISO RGD:1344166 1624291 (PMID:17008324) RGD PMID:17008324 mitochondrial intermembrane space ISO RGD:1551416 1624291 (MGI:2179175, PMID:11847212) RGD MGI:2179175 , PMID:11847212 mitochondrial intermembrane space ISS UniProtKB:P58281 1600115 GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 mitochondrial membrane IBA MGI:MGI:1921256 more ... 13792537 PMID:21873635 GO_Central mitochondrial outer membrane ISO RGD:1344166 1624291 (PMID:12504110) RGD PMID:12504110 mitochondrial outer membrane ISS UniProtKB:O60313 1600115 GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 mitochondrion colocalizes_with IDA 7800723 RGD mitochondrion ISO RGD:1551416 1624291 (MGI:2179175 more ... RGD MGI:2179175 more ... mitochondrion ISO RGD:1344166 1624291 (PMID:17545159) RGD GO_REF:0000052, PMID:17545159 nucleoplasm ISO RGD:1344166 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:O60313 , ensembl:ENSP000003546811600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function cardiolipin binding ISO RGD:1344166 1624291 (PMID:20185555) RGD PMID:20185555 cardiolipin binding ISS UniProtKB:O60313 1600115 GO_REF:0000024 UniProt GO_REF:0000024 GTP binding IEA UniProtKB-KW:KW-0342 1600115 GO_REF:0000043 UniProt GO_REF:0000043 GTPase activity ISS UniProtKB:O60313 1600115 GO_REF:0000024 UniProt GO_REF:0000024 GTPase activity IBA PANTHER:PTN000170013 more ... 13792537 PMID:21873635 GO_Central GTPase activity ISO RGD:1344166 1624291 (PMID:20185555), (PMID:27667664) RGD PMID:20185555 , PMID:27667664 kinase binding IPI RGD:1591334 13209141 RGD microtubule binding IBA FB:FBgn0003392 , PANTHER:PTN000170013 13792537 PMID:21873635 GO_Central phosphatidic acid binding ISO RGD:1344166 1624291 (PMID:20185555) RGD PMID:20185555 phosphatidic acid binding ISS UniProtKB:O60313 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein binding ISO RGD:1344166 1624291 UniProtKB:Q12983 more ... RGD PMID:20436456 more ... protein binding ISO RGD:1551416 1624291 UniProtKB:Q9CRB9 more ... RGD MGI:5009773 more ... protein-containing complex binding IDA 13204842 oligomerization RGD
Gene-Chemical Interaction Annotations
